Page last updated: 2024-08-17

folic acid and Disease Models, Animal

folic acid has been researched along with Disease Models, Animal in 429 studies

Research

Studies (429)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (7.23)	18.7374
1990's	12 (2.80)	18.2507
2000's	97 (22.61)	29.6817
2010's	227 (52.91)	24.3611
2020's	62 (14.45)	2.80

Authors

Authors	Studies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Alkouri, R; Blond, E; Boucher, JL; Coarelli, G; Croon, M; Darios, F; Durr, A; El Hachimi, KH; Elshafie, S; Ewenczyk, C; Fellmann, F; Galatolo, D; Gazi, AD; Giavalisco, P; Gleeson, JG; Goizet, C; Issa, M; Kemlin, I; Kuntzer, T; Lamari, F; Le Corre, L; Legendre, M; Legrand, A; Marelli-Tosi, C; Mathieu, S; Mignot, C; Mochel, F; Mourier, A; Parodi, L; Perin, S; Picaud, S; Popovic, M; Pujol, C; Renaud, M; Rodriguez, D; Santorelli, FM; Saracino, D; Seyer, A; Steculorum, SM; Stevanin, G; Thomas, P; Trifunovic, A; Trimouille, A; Tse, C; Valet, M; Villain, N; Zaki, MS; Zuily, S	1
Chen, M; Gao, Y; Liang, H; Liu, B; Nie, J; Wen, X; Zhong, C	1
Dai, S; Hu, F; Liu, Y; Meng, T; Qiu, G; Wen, L; Yu, F; Yuan, H; Zhou, X; Zhu, Y	1
Chung, HY; Chung, KW; Ha, S; Im, DS; Jang, CW; Jeong, S; Kim, J; Yang, Y	1
Chen, ZY; Liang, H; Ma, AG; Ma, WJ; Wang, QZ; Zheng, Y	1
Chang, HH; Chang, WC; Chen, YF; Guo, YR; Huang, TH	1
Bony, BA; Chatzizisis, YS; Curtis, ET; Gee, CC; Kievit, FM; McCue, IS; Miller, HA; Pedrigi, RM; Ripperda, TJ; Schake, MA	1
Yan, LJ	1
Cannata-Ortiz, P; Carrasco, S; Fontecha-Barriuso, M; Guerrero-Mauvecin, J; Lopez-Diaz, AM; Martin-Sanchez, D; Mendez-Barbero, N; Ortiz, A; Ruiz-Ortega, M; Saiz, ML; Sanchez-Niño, MD; Sanz, AB	1
Chang, YM; Chen, RJ; Chiu, PL; Ho, TJ; Huang, CY; Ju, DT; Kao, HC; Lu, CY; Su, YC; Yang, LY	1
Amada, N; Futamura, T; Kakumoto, Y; Maeda, K	1
Avigan, MI; Beland, FA; da Costa, GG; de Conti, A; Nagumalli, SK; Pogribny, IP; Rusyn, I; Tryndyak, VP; Willett, RA	1
Ahlawat, P; Bal, A; Phutela, K; Sharma, S; Singh, N	1
Chen, J; Chen, X; Ge, Y; Huang, K; Lin, Z; Lv, Z; Pan, Y; Sun, X; Yao, Q; Yu, H	1
Adams, GP; Bradbury, MS; Chen, F; Chen, PM; Gardinier, TC; Germano, G; Khor, T; Ma, K; Patel, V; Turker, MZ; Venkatesan, AM; Wiesner, UB; Wu, F	1
Cai, H; Huang, K; Wu, Y; Youn, JY; Zhang, Y	1
Boldt, ABW; Dos Santos, PI; Kretzschmar, GC; Lima, MMS; Macedo, DA; Ribeiro Pinto, LF; Rodrigues, LS; Soares-Lima, SC; Targa, ADS	1
Eljabri, S; James, C; Miyan, J; Miyan, S; Moshkdanian, G; Naz, N	1
Cai, A; Hou, Y; Huang, M; Mou, S; Xia, J; Xu, Y; Yang, W	1
Aragaki, M; Bernards, N; Gregor, A; Hiraishi, Y; Ishiwata, T; Sata, Y; Yasufuku, K	1
Aguiar-Geraldo, JM; Menegas, S; Peper-Nascimento, J; Possamai-Della, T; Quevedo, J; Valvassori, SS	1
Jin, H; Sun, K; Xing, Y; Yu, F; Zhao, W; Zheng, X	1
Feiten, AF; Ittner, LM; Ke, YD; Sontag, E; Sontag, JM; Taleski, G; van Hummel, A	1
Copp, AJ; De Young, T; Dontsova, V; Goddard, C; Greene, NDE; Laurette, EY; Leung, KY; MacKenzie, B; Mohan, H; Nguyen, J; Sanghvi, T; Serghides, L; Sled, JG; Tejada, O; Yee, A	1
Caro-Vega, JM; Fernández-Santos, B; Lao-Pérez, M; Mesa-Cruz, C; Morón, FJ; Reyes-Corral, M; Vallejo-Grijalba, C; Ybot-González, P	1
Assis Gomes, D; Dantas Cassali, G; de Barros, ALB; de Miranda, MC; de Oliveira Silva, J; Fernandes, RS; Ferreira, TH; Machado Botelho, AF; Martins Melo, M; Oliveira, MC; Ramos Oda, CM; Rubello, D; Townsend, DM	1
Chang, IH; Choi, YW; Goo, YT; Kang, TH; Kim, CH; Kim, SY; Lee, SJ; Song, SH; Whang, YM; Yoon, HY	1
Bailey, JL; Benoit-Biancamano, MO; Charest, PL; Dalvai, M; Droit, A; Herst, PM; Joly-Beauparlant, C; Kimmins, S; Lessard, M; MacFarlane, AJ; Navarro, P; Trasler, J	1
Hendry, BM; Hung, G; Newbury, LJ; Sharpe, CC; Wang, JH	1
Dagnaes-Hansen, F; Jakobsen, M; Kjems, J; Nielsen, NC; Song, P; Vinding, MS; Vu-Quang, H	1
Burns, AJ; Copp, AJ; de Castro, SCP; Dunlevy, LPE; Greene, NDE; Leung, KY; Massa, V; Palmer, A; Savery, D; Sudiwala, S	1
Boufaied, N; Feng, D; Gerarduzzi, C; Henley, N; Ngov, C	1
Aguiar-Geraldo, JM; Andersen, ML; Cararo, JH; Dal-Pont, GC; Menegas, S; Possamai-Della, T; Quevedo, J; Valvassori, SS; Varela, RB	1
Cong, Y; Liu, H; Zhou, Y	1
Cong, Z; Lam, KS; Liao, YH; Ma, SQ; Yang, FF; Zhang, L	1
Cannata, P; Castelo-Branco, RC; Córdoba-David, G; Duro-Castano, A; González-Guerrero, C; Ortiz, A; Ramos, AM; Sanz, AB; Vicent, MJ	1
Kamel, MA; Youssry, S	1
Chen, B; Guo, M; Jin, C; Li, J; Peng, X; Song, X; Yang, J; Yu, T; Zeng, J; Zhang, Y; Zhao, S	1
Ko, HY; Lee, YL; Lin, YL; Simanjuntak, Y; Yu, GY	1
Chen, J; Evivie, SE; Guan, J; Huo, G; Jiao, W; Li, B; Li, N; Shi, J; Wang, S; Yan, F	1
Cheng, C; Huang, J; Ma, L; Qiu, L; Tang, Y; Wang, L; Xiang, X; Yan, F; Zhu, B	1
Ashcraft, K; Bacich, D; Liss, MA; Satsangi, A	1
Fan, JG; Gong, ZZ; Pan, Q; Sun, C; Xin, FZ; Zhang, RN; Zhao, ZH	1
Chmurzynska, A; Kołodziejski, P; Radziejewska, A; Suliburska, J	1
Cao, Q; Chen, J; Chen, X; Huang, C; Pollock, C; Shi, Y; Yi, H; Zhao, Y	1
George, AK; Singh, M; Smolenkova, I; Stanisic, D; Tyagi, SC	1
Cadena, MRS; Cadena, PG; Marrs, JA; Sarmah, S	1
Díaz-Rodríguez, E; Pandiella-Alonso, A; Sanz, E	1
Connor, KL; Palladino, E; Van Mieghem, T	1
Akgun, E; Boyacioglu, M; Kum, S	1
Ali, T; Kaur, J; Sharma, R	1
Bayer, M; Boller, S; Edwards-Hicks, J; Grosschedl, R; Grün, D; Herman, JS; Klein-Geltink, R; Kometani, K; Li, R; Pearce, EL; Ramachandran, H; Ramamoorthy, S	1
Emami, J; Hasanzadeh, F; Kazemi, M; Lavasanifar, A; Minaiyan, M; Mirian, M; Mokhtari, M	1
Abnous, K; Alibolandi, M; Hosseinzadeh, H; Mohammadi, M; Naserifar, M; Ramezani, M; Taghdisi, SM	1
de Moreno de LeBlanc, A; LeBlanc, JG; Levit, R; Savoy de Giori, G	1
Dai, Q; Hu, G; Jiang, Y; Liao, X; Meng, J; Peng, Z; Tao, L; Xie, Y; Yu, Y; Zhang, Y	1
Jiang, H; Maclean, KN; Mclagan, BM; Phinney, WN; Roede, JR; Stabler, SP	1
Agrawal, S; Gamian, A; Hamar, P; Krawczyk, M; Krenács, T; Makuch, S; Pastuch-Gawołek, G; Szeja, W; Szkudlarek, D; Wiśniewski, J; Woźniak, M	1
Gao, Y; Kong, L; Sun, X; Tan, Y; Wang, S; Wang, T; Wu, X; Xu, Q; Xu, Y; Ye, J; Yuan, M; Zheng, B	1
Ayvaz, Ş; Cho, SJ; Choi, HS; Choy, HE; Dooley, S; Fliser, D; Jung, YS; Kim, DH; Kim, DK; Kim, HS; Kim, J; Kim, YH; Lee, CH; Lee, IK; Lim, D; Na, SY; Nittka, S; Radhakrishnan, K; Schunk, SJ; Speer, T	1
Cheng, Q; Di, Y; Fan, J; Kang, M; Lan, J; Li, J; Li, Z; Ren, W; Tian, Y; Wei, C; Zhai, C; Zheng, Q	1
Chen, Q; Chen, X; Ding, Y; Gao, R; Geng, Y; He, J; Liu, X; Mu, X; Wang, Y; Zhang, L; Zhang, Y	1
Doorneweerd, DD; Low, PS; Putt, KS; Venkatesh, C; Xia, W	1
Fu, P; Guo, F; Huang, R; Li, L; Liu, J; Ma, L; Tan, Z; Tao, S; Zeng, X	1
Bagio, E; Barichello, T; Bernades, G; Bonfante, S; da Rosa, N; de Oliveira Junior, AN; Fortunato, JJ; Garbossa, L; Generoso, J; Goldim, MP; Joaquim, L; Lanzzarin, E; Machado, RS; Mathias, K; Metzker, K; Novochadlo, M; Petronilho, F	1
Au-Yeung, KKW; Madduma Hewage, S; O, K; Siow, YL; Tu, GW; Wijerathne, CUB; Woo, CWH; Yang, C; Zhu, T	1
Elkalla, WS; Mansour, NM; Ragab, YM; Ramadan, MA	1
Hakroush, S; Korsten, P; Schridde, L; Ströbel, P; Tampe, B; Tampe, D; Zeisberg, M	1
Alves, CSV; Barcellos, AS; Budni, J; Canever, L; Citadin, S; Damázio, L; De Luca, LA; Garcez, ML; Mastella, G; Polla, JV; Quevedo, J; Zugno, AI	1
Cui, S; Gao, Y; Huang, G; Li, W; Lv, X; Wang, P	1
Chen, J; Duan, S; He, J; Hu, Z; Lu, X; Su, J; Yang, N; Zhang, Z; Zhao, Y; Zhou, S	1
Hu, Z; Liang, H; Mitch, WE; Wang, Y; Yan, J; Zhang, Z	1
Abbott, GW; Alachkar, A; Civelli, O; Hamzeh, AR; Lee, SM; Sanathara, N; Wang, L; Wang, Z; Xu, X; Yoshimura, R	1
Gao, L; Liu, X; Liu, Y; Wu, J; Xu, M; Yu, L	1
Cheng, X; Lee, RJ; Li, Y; Liu, J; Sun, F; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M	1
Han, MK; Liu, D; Merlin, D; Wang, L; Xu, C; Zhang, M	1
Bischof, RJ; Clifton, VL; Gatford, KL; Giles, LC; Heinemann, GK; Hunter, DS; Kind, KL; Lien, YC; Liu, H; Lu, W; Owens, JA; Rabinowitz, JD; Simmons, RA; Wooldridge, AL	1
Akbari, G; Asghari, A; Fakouri, A; Mortazavi, P	1
Chen, RJ; Chiu, CH; Huang, CY; Huang, RS; Ju, DT; Kuo, WW; Lin, CC; Lin, KH; Liu, JS; Shen, CY; Viswanadha, VP	1
Bradner, JE; Ferrando, AA; Kitara, S; Kung, AL; Qi, J; Roti, G; Sanchez-Martin, M; Saur Conway, A; Stegmaier, K; Su, A; Varca, AC; Wu, L	1
Egido, J; Falke, LL; Goldschmeding, R; Mezzano, S; Morgado-Pascual, JL; Ortiz, A; Rayego-Mateos, S; Rodrigues-Diez, R; Rodrigues-Diez, RR; Ruiz-Ortega, M	1
Asai, A; Colvin, H; Doki, Y; Ishii, H; Kawamoto, K; Konno, M; Koseki, J; Kudo, T; Mori, M; Nishida, N; Sakai, D; Satoh, T	1
Cao, Q; Chen, J; Chen, XM; Huang, C; Pollock, CA; Shi, Y; Yi, H; Zhang, L; Zhao, Y	1
Ayala-López, W; Chelvam, V; Low, PS; Poh, S; Putt, KS	1
Antony, AC; Kusumanchi, P; Stabler, SP; Tang, YS; Xiao, S; Zhang, Y	1
Alnouti, Y; Araínga, M; Edagwa, B; Gautam, N; Gendelman, HE; Hilaire, J; Lin, Z; Liu, X; McMillan, J; Palandri, D; Puligujja, P; Smith, N; Zhou, T	1
Chen, X; Dai, Y; Fan, W; Gao, G; Jacobson, O; Kiesewetter, DO; Ma, Y; Shan, L; Yung, BC; Zhai, K; Zhang, F; Zhu, G; Zhuo, X	1
Hou, J; Li, R; Liu, B; Luo, E; Qiao, Y; Tang, C; Wang, D; Yan, G; Zhu, B	1
Ben-Hur, T; Blatch, D; Ekstein, D; Eyal, S; Han, H; Inbar, D; Mann, A; Portnoy, E; Shmuel, M	1
Arning, E; Bahous, RH; Bottiglieri, T; Caudill, MA; Christensen, KE; Deng, L; Hou, W; Jerome-Majewska, LA; Malysheva, OV; Rozen, R	1
Cross, AH; Evans, E; Piccio, L	1
Kipp, KR; Kruger, SL; Leamon, CP; Parker, N; Schimmel, MF; Shillingford, JM; Weimbs, T	1
Bora, C; Candiloro, KM; Coleman, TP; Connolly, DC; Davis, B; Galati, CA; Ganta, S; Litwin, S; Maglaty, MA; Morse, AB; Nack, AH; O'Brien, SW; Patel, NR; Piroyan, A; Solon, AL	1
Budni, J; Canever, L; Carvalho, G; Damázio, L; Fachim, I; Freire, TG; Gava, FF; Godói, AK; Gomes, S; Mastella, GA; Michels, C; Peterle, BR; Quevedo, J; Valvassori, SS; Zugno, AI	1
Abatti, M; Abelaira, HM; Dal-Pizzol, F; Darabas, AC; de Moura, AB; de Souza, TG; Dos Santos, TR; Fucillini, V; Maciel, AL; Matos, D; Michels, M; Parzianello, M; Quevedo, J; Réus, GZ; Vieira, AC	1
Axelrod, J; Durlacher-Betzer, K; Hassan, A; Levi, R; Naveh-Many, T; Silver, J	1
Arning, E; Bottiglieri, T; Hoffman, A; Qian, H; Sontag, E; Sontag, JM; Taleski, G; Wasek, B	1
Cai, Z; Cui, X; Fu, Z; Gu, X; Guo, X; Ji, C; Li, H; Wang, X; Xie, K; Xu, P; You, L; Zhu, L	1
Alagarsamy, V; Alok, S; Chandrababu, R; Kannan, S; Thondhi, P; Varukattu, N; Vivek, R	1
Chen, M; Gao, X; Li, J	1
Arias, M; Cannata-Ortiz, P; Egido, J; Gómez-Alamillo, C; González-Guerrero, C; Mezzano, S; Morgado-Pascual, JL; Ortiz, A; Ramos, AM; Ramos-Barron, MA; Ruiz-Ortega, M	1
Emmerson, JT; Jadavji, NM; MacFarlane, AJ; Shanmugalingam, U; Smith, PD; Willmore, WG	1
Dou, M; Gong, A; Han, L; Liang, H; Ma, A; Wang, Q; Wu, Y	1
Marrs, JA; Muralidharan, P; Sarmah, S	1
Jiang, K; Lerman, LO; Macura, SI; Mishra, PK; Ponzo, TA; Tang, H	1
Adamowicz, K; Foresto-Neto, O; Honarpisheh, M; Koehler, P; Koziel, J; Kraft, F; Lech, M; Potempa, J; Steiger, S; von Rauchhaupt, E	1
Guo, J; Li, Q; Ni, S; Wang, JZ; Yang, Y	1
Bayliss, G; Guan, Y; Tolbert, T; Zang, X; Zhao, TC; Zhou, X; Zhuang, S	1
Chen, X; He, D; Qin, L; Wang, Y; Zhou, Y	1
Al-Attabi, Z; Al-Malky, RN; Al-Maskari, SNM; Al-Ruqaishi, BRS; Ali, A; Deth, RC; Dong, J; Guizani, N; Padmanabhan, S; Rahman, MS; Taranikanti, V; Waly, MI	1
Barrio Asensio, MDC; Del Río Sevilla, A; López-Alonso, JM; Murillo González, J; Sijilmassi, O	1
Aparicio-Trejo, OE; Briones-Herrera, A; Hernández-Pando, R; León-Contreras, JC; Pedraza-Chaverri, J; Reyes-Fermín, LM; Sánchez-Lozada, LG; Tapia, E	1
Aiello, P; Bello, C; Canali, R; Carminati, D; Comitato, R; Devirgiliis, C; Guantario, B; Meucci, A; Motta, V; Natella, F; Perozzi, G; Roselli, M; Tidona, F; Trevisi, P; Virgili, F; Zinno, P	1
Ahmad, I; Ain, MR; Ibrahim, IAA; Md, S; Nassir, AM; Shahzad, N; Waris, M	1
Cherrington, NJ; Hardwick, RN; Lake, AD; Leamon, CP; Low, PS	1
Bossenmeyer-Pourié, C; Daval, JL; Geoffroy, A; Guéant, JL; Helle, D; Pourié, G; Saber-Cherif, L; Umoret, R	1
Fukuyama, T; Makino, E; Ohnuma-Koyama, A; Ohtsuka, R; Okazaki, Y; Tajiki-Nishino, R; Tajima, H; Takahashi, N; Watanabe, Y	1
Fu, H; Hong, X; Hou, FF; Liao, J; Lin, L; Liu, Y; Zhou, D; Zhu, H	1
Azevedo, A; Faria, J; Martel, F; Negalha, G	1
Celardo, I; Costa, AC; Garrido-Maraver, J; Lehmann, S; Loh, SHY; Martins, LM	1
Becker, ML; Funk, RS; Kiptoo, P; Siahaan, TJ; Singh, RK; van Haandel, L	1
Cabello, R; Cannata-Ortiz, P; Carrasco, S; Fontecha-Barriuso, M; Gómez, MJ; Gonzalez-Enguita, C; Martín-Sánchez, D; Martinez-Moreno, JM; Monsalve, M; Ortiz, A; Ruiz-Andrés, O; Ruiz-Ortega, M; Sánchez-Niño, MD; Sanchez-Ramos, C; Sanz, AB	1
Joshi, SR; Nandi, AA; Wadhwani, NS	1
Angle, C; Behan, NA; Chan, D; Karahan, G; MacFarlane, AJ; Martel, J; Rahimi, S; Trasler, JM	1
Lei, XW; Li, Q; Liu, Y; Yang, KH; Zhang, JZ; Zhang, YM	1
Cheng, Y; Jiang, H; Li, J; Liu, Q; Liu, Y; Qiu, Z; Shen, Y; Xi, S; Xiao, C; Xie, Z; Xue, Z; Yan, J; Zhang, L	1
Chang, S; Li, B; Li, R; Liang, L; Liu, C; Niu, B; Qin, C; Wang, L; Wang, X; Zhang, L; Zhang, M; Zhang, T	1
Bodnár, M; Borbély, J; Garai, I; Hajdu, I; Kerekes, K; Kertész, I; Kollár, J; Körhegyi, Z; Kun, S; Rózsa, D; Trencsényi, G; Varga, J	1
Cao, Y; Li, L; Li, Q; Sun, C; Wu, H; Wu, L; Xia, W; Zhang, Q; Zou, M	1
Dworkin, LD; Flickinger, B; Ge, Y; Gong, R; Jiang, C; Liu, Z; Lu, M; Malhotra, DK; Qiao, Y; Wang, P	1
Caro-Vega, J; Finnell, RH; Lin, Y; López-Escobar, B; Wlodarczyk, BJ; Ybot-González, P	1
Beland, FA; de Conti, A; James, SJ; Kutanzi, K; Latendresse, JR; Melnyk, S; Montgomery, B; Muskhelishvili, L; Pogribna, M; Pogribny, IP; Rusyn, I; Tryndyak, V	1
Finnell, RH; Niswander, LA; Shaw, GM; Wallingford, JB	1
Meyer, BJ; Milte, CM; Parletta, N	1
Delaney, C; Hewagama, A; Hoeltzel, MF; Johnson, K; Mickelson, B; Richardson, BC; Sawalha, AH; Strickland, FM; Wu, A; Yung, R	1
Cai, H; Chen, Q; Li, K; Liu, H; Peng, C; Shen, M; Shi, X; Wen, S; Zhang, G	1
Chelvam, V; Cresswell, G; Low, PS; Shen, J	1
Röckl, T; Scheller, C; Scheller, K; Schubert, J	1
Christov, M; Goltzman, D; Havasi, A; Jüppner, H; Leaf, DE; Pajevic, PD; Pereira, RC; Waikar, SS; Wolf, M	1
Linask, KK	1
Albright, KA; Neuman, JC; Schalinske, KL	1
Copp, AJ; Greene, ND; Stanier, P	1
He, EY; Ren, J; Roe, ND; Wu, Z	1
Guan, T; Guan, Z; Li, G; Niu, B; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhu, Z	1
Been, RA; DeCoursin, KJ; Hooten, AJ; Janik, CL; Johnson, KJ; Langer, EK; Largaespada, DA; Linden, MA; Marek, CA; Nagel, CW; Reed, RC; Ross, JA; Schutten, MM	1
Copp, AJ; De Castro, SC; Greene, ND; Leung, KY; Savery, D	1
Arai, H; Kimura, T; Kondo, A; Miyajima, M; Shimoji, K; Tange, Y	1
Obeid, R	1
Kappen, C	2
Fox, JG; Wang, TC	1
Aktug, H; Erbas, O; Oltulu, F; Yilmaz, M	1
Chen, X; Chen, YH; Dong, XT; Wang, H; Wu, SX; Xia, MZ; Xu, DX; Zhang, C; Zhao, M; Zhou, J	1
MacFarlane, AJ; McEntee, MF; Stover, PJ	1
Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z	1
Gelineau-van Waes, J; Riley, RT; Voss, KA	1
de Jong, M; Groen, HC; Müller, C; Van der Heiden, K; van der Steen, AF; van Thiel, BS; Wentzel, JJ; Winkel, LC	1
Bayliss, G; Gong, R; Tang, J; Yan, H; Yan, Y; Zhao, TC; Zhuang, S	1
Allender, EV; Boshnjaku, V; Finnell, RH; Ichi, S; Mania-Farnell, B; Mayanil, CS; McLone, DG; Shim, KW; Siddiqui, MR; Tomita, T; Tsurubuchi, T; Xi, G	1
Dejgaard, K; Deng, L; Leclerc, D; Mazur, A; Nilsson, T; Rozen, R; Wu, Q	1
Chen, Q; Finnell, RH; Gray, JD; Gross, SS; Hansler, A; Ross, ME	1
Cherrington, NJ; Coen, M; Goedken, MJ; Hardwick, RN; Holmes, E; Jin, Z; Kyriakides, M	1
Nadeau, JH; Nakouzi, GA	1
Barichello, T; Budni, J; Danielski, LG; Dominguini, D; Ferrari, P; Generoso, JS; Gubert, C; Jornada, LK; Kapczinski, F; Moreira, AP; Petronilho, F; Quevedo, J; Simões, LR; Steckert, AV	1
Cui, W; Liu, J; Sun, X; Xie, X; Zhang, D; Zhu, Y	1
Aliani, M; Eskin, MN; Giesbrecht, HE; Suh, M; Young, JK	1
He, W; Li, C; Lu, S; Meng, T; Shi, B	1
Fathe, K; Finnell, RH; Person, MD	1
Dong, Y; Feng, J; Jiang, C; Kong, W; Liu, B; Liu, Z; Pang, Y; Sun, L; Sun, W; Wang, X; Xu, M	1
Chen, Y; Dong, Y; Guan, Z; Niu, B; Niu, Y; Wang, J; Wang, X; Zhang, T	1
Singh, SK; Srikrishna, S; Srivastav, S; Yadav, AK	2
Candiani, M; Di Martino, M; Parazzini, F; Viganò, P	1
Field, MS; Finkelstein, JL; Martiniova, L; Perry, CA; Stover, PJ	1
Luft, FC	1
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Chandler, CJ; Duplantier, RB; Halsted, CH; Naughton, CA	1
Borman, LS; Branda, RF	1
Fink, M; Henry, M; Tange, JD	1
Chanarin, I; Deacon, R; Lumb, M; Muir, M; Perry, J	1
Lapin, IP; Ryzhov, IV	1
Giwercman, A; Skakkebaek, NE	1
Metz, J; van der Westhuyzen, J	1
Olney, JW	1
Ferm, VH; Graham, JM	1
Harris, JW; Hines, JD; Kark, JA; Victor, M	1
Siddons, RC	1
Abbott, BJ; Congleton, GF; Dudeck, LE; Gargus, JL; Geran, RI	1
Racusen, LC; Smith, DB	1
Hussein, HS	1
Dubach, UC; Jösch, W; Schlumpf, V; Schmidt, U	1
Allen, AA; Haltalin, KC; Nelson, JD; Woodman, EB	1
Bruce-Chwatt, LJ; Dorrell, J; Topley, E	1

Reviews

50 review(s) available for folic acid and Disease Models, Animal

Article	Year
Folic acid-induced animal model of kidney disease. Animal models and experimental medicine, 2021, Volume: 4, Issue:4 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Folic Acid; Kidney; Renal Insufficiency, Chronic	2021
Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review. Nutrients, 2020, Aug-31, Volume: 12, Issue:9 Topics: Amino Acids; Animals; Antineoplastic Agents; Apoptosis; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Cinnamomum zeylanicum; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Folic Acid; Glucosamine; Glycyrrhiza; Humans; Neoplasms; Pantothenic Acid; Plant Extracts; Sucrose; Tea; Vitamin B 12; Vitamin B 6; Zinc Sulfate	2020
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review. JAMA neurology, 2018, 08-01, Volume: 75, Issue:8 Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Folic Acid; Ginkgo biloba; Humans; Multiple Sclerosis; Niacin; Pantothenic Acid; Plant Preparations; Probiotics; Pyridoxine; Resveratrol; Riboflavin; Tea; Thiamine; Thioctic Acid; Ubiquinone; Vitamin A; Vitamin B 12; Vitamin D; Vitamin E; Vitamins	2018
Metformin and Breast Cancer: Molecular Targets. Journal of mammary gland biology and neoplasia, 2019, Volume: 24, Issue:2 Topics: AMP-Activated Protein Kinases; Animals; Breast Neoplasms; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Incidence; Mechanistic Target of Rapamycin Complex 1; Metabolic Networks and Pathways; Metformin; MicroRNAs; Molecular Targeted Therapy; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Xenograft Model Antitumor Assays	2019
The continuing challenge of understanding, preventing, and treating neural tube defects. Science (New York, N.Y.), 2013, Mar-01, Volume: 339, Issue:6123 Topics: Amphibians; Animals; Disease Models, Animal; Embryo, Nonmammalian; Folic Acid; Folic Acid Deficiency; Humans; Mutation; Neural Tube Defects; Primary Prevention	2013
Nutritional modulation of cognitive function and mental health. The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:5 Topics: Animals; Antioxidants; Brain; Chronic Disease; Cognition; Diet, Mediterranean; Disease Models, Animal; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Life Style; Mental Health; Nutritional Physiological Phenomena; Risk Factors; Vitamin B Complex	2013
Neural tube defects: recent advances, unsolved questions, and controversies. The Lancet. Neurology, 2013, Volume: 12, Issue:8 Topics: Animals; Databases, Factual; Disease Models, Animal; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects	2013
Genetic studies of myelomeningocele. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013, Volume: 29, Issue:9 Topics: Animals; Disease Models, Animal; Folic Acid; Glucose; Humans; Meningomyelocele; MicroRNAs	2013
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients, 2013, Sep-09, Volume: 5, Issue:9 Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine	2013
Modeling anterior development in mice: diet as modulator of risk for neural tube defects. American journal of medical genetics. Part C, Seminars in medical genetics, 2013, Volume: 163C, Issue:4 Topics: Anencephaly; Animals; Cleft Lip; Cleft Palate; Diabetes, Gestational; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Gene-Environment Interaction; Humans; Maternal Nutritional Physiological Phenomena; Mice; Morphogenesis; Neural Tube Defects; Pregnancy	2013
Nutrition implications for fetal alcohol spectrum disorder. Advances in nutrition (Bethesda, Md.), 2014, Volume: 5, Issue:6 Topics: Alcohol Drinking; Animals; Antioxidants; Brain; Choline; Dietary Supplements; Disease Models, Animal; Docosahexaenoic Acids; Female; Fetal Alcohol Spectrum Disorders; Fetal Development; Folic Acid; Humans; Infant; Micronutrients; Nutritional Status; Pregnancy; Prenatal Nutritional Physiological Phenomena; Vitamin A; Zinc	2014
Dietary components and uterine leiomyomas: a review of published data. Nutrition and cancer, 2015, Volume: 67, Issue:4 Topics: Animals; Ascorbic Acid; Carotenoids; Dairy Products; Diet; Dietary Fats; Dietary Fiber; Disease Models, Animal; Folic Acid; Fruit; Humans; Leiomyoma; Meat; Phytoestrogens; Risk Factors; Seafood; Soy Foods; Vegetables; Vitamin A; Vitamin D; Vitamin E	2015
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. Neuropeptides, 2016, Volume: 56 Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Folic Acid; Lamotrigine; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Triazines	2016
Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds. Molecular nutrition & food research, 2016, Volume: 60, Issue:6 Topics: Animals; Arsenic; Benzhydryl Compounds; Breast Neoplasms; Diet; Disease Models, Animal; Endocrine Disruptors; Epigenesis, Genetic; Female; Folic Acid; Food Analysis; Food Contamination; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genistein; Humans; Isothiocyanates; Phenols; Phytochemicals; Receptors, Aryl Hydrocarbon; Vitamin B 12	2016
Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition. The Proceedings of the Nutrition Society, 2016, Volume: 75, Issue:3 Topics: Animals; Biomarkers; Blood Pressure; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Folic Acid; Genotype; Homozygote; Humans; Ireland; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Requirements; Nutritional Status; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Riboflavin; Riboflavin Deficiency; Risk Factors; United Kingdom	2016
Inositol, neural tube closure and the prevention of neural tube defects. Birth defects research, 2017, 01-30, Volume: 109, Issue:2 Topics: Animals; Clinical Trials as Topic; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Humans; Inositol; Inositol Phosphates; Maternal Nutritional Physiological Phenomena; Mice; Neural Tube; Neural Tube Defects; Phosphatidylinositols; Pregnancy	2017
Mouse models to elucidate mechanisms of folate-related cancer pathologies. Nutrition reviews, 2008, Volume: 66 Suppl 1 Topics: Animals; Cell Nucleus; Colonic Neoplasms; Disease Models, Animal; Folic Acid; Gene Expression; Glycine Hydroxymethyltransferase; Humans; Mice; Nutritional Physiological Phenomena	2008
Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants. Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:4 Topics: Animals; Disease Models, Animal; Folic Acid; Humans; Metabolic Networks and Pathways; Mice; Mice, Mutant Strains; Neural Tube Defects; Species Specificity	2009
Understanding the causes and prevention of neural tube defects: Insights from the splotch mouse model. Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:4 Topics: Animals; Disease Models, Animal; Embryo, Mammalian; Environment; Epistasis, Genetic; Folic Acid; Folic Acid Deficiency; Humans; Mice; Mice, Transgenic; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor	2009
Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 28, Issue:1 Topics: Abnormalities, Drug-Induced; Adolescent; Animals; Anticonvulsants; Autistic Disorder; Child; Child Development; Child, Preschool; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Fetus; Folic Acid; Humans; Infant; Maternal-Fetal Exchange; Milk, Human; Nervous System Diseases; Neural Tube Defects; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment; Semen; Syndrome; Teratogens; Valproic Acid	2009
Genetics and development of neural tube defects. The Journal of pathology, 2010, Volume: 220, Issue:2 Topics: Animals; Causality; Disease Models, Animal; Folic Acid; Humans; Mice; Neural Tube; Neural Tube Defects; Neurulation; Signal Transduction	2010
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:8 Topics: Animals; Ciliary Motility Disorders; Disease Models, Animal; Epigenomics; Female; Folic Acid; Humans; Inositol; Male; Mice; Mice, Mutant Strains; Mutation; Neural Crest; Neural Tube Defects; Receptors, Proteinase-Activated	2010
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. The Journal of craniofacial surgery, 2010, Volume: 21, Issue:5 Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models, Animal; DNA Methylation; Folic Acid; Genetic Predisposition to Disease; Hydrocortisone; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenytoin; Polymerase Chain Reaction; Risk Factors	2010
Mouse as a model for multifactorial inheritance of neural tube defects. Birth defects research. Part C, Embryo today : reviews, 2012, Volume: 96, Issue:2 Topics: Anencephaly; Animals; Disease Models, Animal; Folic Acid; Genetic Predisposition to Disease; Humans; Mice; Multifactorial Inheritance; Neural Tube Defects; Spinal Dysraphism	2012
Folate, alcohol, and liver disease. Molecular nutrition & food research, 2013, Volume: 57, Issue:4 Topics: Absorption; Alcohol Drinking; Animals; Antioxidants; Disease Models, Animal; Epigenesis, Genetic; Ethanol; Folic Acid; Folic Acid Deficiency; Gene Expression; Humans; Intestine, Small; Liver; Liver Diseases, Alcoholic; Methionine; Methylation	2013
The genetic basis of mammalian neurulation. Nature reviews. Genetics, 2003, Volume: 4, Issue:10 Topics: Animals; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Developmental; Humans; Mice; Mice, Neurologic Mutants; Mutation; Nervous System; Neural Tube Defects; Signal Transduction	2003
Folate and cancer: a review of the literature. Nutrition and cancer, 1994, Volume: 22, Issue:2 Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Humans; Methylation; Neoplasms; Risk Factors	1994
Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. The Journal of nutrition, 2004, Volume: 134, Issue:4 Topics: Animals; Biological Transport; Craniofacial Abnormalities; Culture Techniques; Disease Models, Animal; Folic Acid; Food Contamination; Fumonisins; Humans; Mexico; Mice; Neural Tube Defects; Risk Factors; Sphingolipids; Texas; Zea mays	2004
Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environmental and molecular mutagenesis, 2004, Volume: 44, Issue:1 Topics: Animals; Anticarcinogenic Agents; Colorectal Neoplasms; Diet; Disease Models, Animal; DNA Methylation; DNA Replication; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Humans; Models, Biological; Time Factors	2004
Lighting up tumors with receptor-specific optical molecular probes. Technology in cancer research & treatment, 2004, Volume: 3, Issue:4 Topics: Animals; Bombesin; Carbocyanines; Carrier Proteins; Cell Membrane; Coloring Agents; Contrast Media; Diagnostic Imaging; Disease Models, Animal; Epidermal Growth Factor; Fluorescent Dyes; Folic Acid; Humans; Light; Models, Chemical; Models, Molecular; Molecular Probes; Neoplasms; Neurotensin; Peptides; Photosensitizing Agents; Somatostatin; Xanthenes	2004
Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways. American journal of medical genetics. Part C, Seminars in medical genetics, 2005, May-15, Volume: 135C, Issue:1 Topics: Animals; Congenital Abnormalities; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation, Developmental; Humans; Mice; Models, Genetic; Pregnancy	2005
The central nervous system in animal models of hyperhomocysteinemia. Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:7 Topics: Animals; Central Nervous System; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Homocystine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12	2005
Toward understanding the genetic basis of neural tube defects. Clinical genetics, 2007, Volume: 71, Issue:4 Topics: Animals; Cell Division; Cell Polarity; Central Nervous System; Cilia; Disease Models, Animal; Female; Folic Acid; Humans; Infant, Newborn; Mice; Neural Tube Defects; Pregnancy; Signal Transduction	2007
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. The American journal of clinical nutrition, 2007, Volume: 86, Issue:1 Topics: Animals; Betaine; Disease Models, Animal; Folic Acid; Humans; Liver Diseases, Alcoholic; Methionine; S-Adenosylmethionine	2007
B vitamins and berries and age-related neurodegenerative disorders. Evidence report/technology assessment, 2006, Issue:134 Topics: Aging; Alzheimer Disease; Animals; Blueberry Plants; Cognition; Disease Models, Animal; Folic Acid; Fragaria; Fruit; Humans; Neurodegenerative Diseases; Parkinson Disease; Plant Extracts; Riboflavin; Thiamine; Vitamin B 12; Vitamin B 6; Vitamin B Complex	2006
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:3 Topics: Adenosine; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Clinical Trials as Topic; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Humans; Immunity, Cellular; Immunosuppression Therapy; Male; Methotrexate; Reactive Oxygen Species; Sensitivity and Specificity; Treatment Outcome	2008
What are the molecular mechanisms of neural tube defects? BioEssays : news and reviews in molecular, cellular and developmental biology, 1998, Volume: 20, Issue:1 Topics: Animals; Disease Models, Animal; Drug Resistance; Female; Folic Acid; Humans; Inositol; Mice; Mice, Mutant Strains; Neural Tube Defects; Pregnancy; Receptors, Retinoic Acid; Tretinoin	1998
Mouse models for neural tube closure defects. Human molecular genetics, 2000, Apr-12, Volume: 9, Issue:6 Topics: Actins; Animals; Disease Models, Animal; Female; Folic Acid; Humans; Male; Mice; Mutation; Neural Tube Defects; Sex Factors	2000
Development and characterization of a rodent model of methanol-induced retinal and optic nerve toxicity. Neurotoxicology, 2000, Volume: 21, Issue:3 Topics: Animals; Disease Models, Animal; Folic Acid; Formates; Humans; Methanol; Optic Nerve; Optic Nerve Diseases; Rats; Retina; Retinal Diseases; Solvents	2000
Pathophysiology, prevention, and potential treatment of neural tube defects. Mental retardation and developmental disabilities research reviews, 2000, Volume: 6, Issue:1 Topics: Animals; Disease Models, Animal; Embryonic and Fetal Development; Folic Acid; Homocysteine; Humans; Incidence; Nervous System; Neural Tube Defects; Preventive Medicine	2000
[Homocysteine and cardiovascular risk]. Wiener medizinische Wochenschrift (1946), 2001, Volume: 151, Issue:1-2 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Arteriosclerosis; Clinical Trials as Topic; Coronary Artery Disease; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Models, Biological; Vitamin B 12	2001
Neural tube defects: prevention by folic acid and other vitamins. Indian journal of pediatrics, 2000, Volume: 67, Issue:12 Topics: Animals; Disease Models, Animal; Folic Acid; Mice; Neural Tube Defects	2000
Curly tail: a 50-year history of the mouse spina bifida model. Anatomy and embryology, 2001, Volume: 203, Issue:4 Topics: Animals; Cell Division; Crosses, Genetic; Disease Models, Animal; Drug Resistance; Environment; Folic Acid; Mice; Mice, Mutant Strains; Mutation; Neural Tube Defects; Spinal Dysraphism; Tail	2001
The role of folate in the prevention of neural tube defects: human and animal studies. Nutrition reviews, 2001, Volume: 59, Issue:8 Pt 2 Topics: Animals; Disease Models, Animal; Embryonic and Fetal Development; Female; Folic Acid; Food, Fortified; Humans; Neural Tube Defects; Pregnancy; Recurrence; Risk Factors	2001
Genetics of neural tube defects. Seminars in pediatric neurology, 2001, Volume: 8, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Disease Models, Animal; Double-Blind Method; Female; Folic Acid; Humans; Infant, Newborn; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Placebos; Pregnancy; Randomized Controlled Trials as Topic; Risk Factors; Transcription Factors; Vitamins	2001
The pharmacology of anticonvulsant drugs. Clinical and experimental neurology, 1978, Volume: 15 Topics: Animals; Anticonvulsants; Biotransformation; Brain; Disease Models, Animal; Electric Stimulation; Energy Metabolism; Epilepsy; Folic Acid; Haplorhini; Humans; Hydrogen; Membrane Potentials; Mice; Neurons; Neurotransmitter Agents; Papio; Potassium; Seizures; Sodium; Synaptic Transmission	1978
Cobalamin-folate interrelations: a critical review. Blood, 1985, Volume: 66, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central Nervous System; Deoxyuridine; Disease Models, Animal; Drug Interactions; Enzyme Activation; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Liver; Methionine; Methylmalonyl-CoA Mutase; Nitrous Oxide; Oxidation-Reduction; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency	1985
[Endogenous convulsants (review)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:1 Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Disease Models, Animal; Dogs; Estrogens; Folic Acid; Homocysteine; Kynurenine; Methionine; Mice; Neurotransmitter Agents; Prostaglandins; Pyridoxal Phosphate; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Spinal Cord	1986
The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review. International journal of andrology, 1986, Volume: 9, Issue:1 Topics: Acrosome; Animals; Bulbourethral Glands; Chemical Phenomena; Chemistry; Contraceptive Agents, Male; Contraceptives, Oral; Disease Models, Animal; Drug Interactions; Fertility; Folic Acid; Hormones; Humans; Male; Sulfasalazine; Testis	1986
The fruit bat as an experimental model of the neuropathy of cobalamin deficiency. Comparative biochemistry and physiology. A, Comparative physiology, 1987, Volume: 88, Issue:2 Topics: Animals; Chiroptera; Disease Models, Animal; Fatty Acids; Folic Acid; Methionine; Nervous System Diseases; Neurotransmitter Agents; Vitamin B 12 Deficiency	1987

Other Studies

379 other study(ies) available for folic acid and Disease Models, Animal

Article	Year
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Implication of folate deficiency in CYP2U1 loss of function. The Journal of experimental medicine, 2021, 11-01, Volume: 218, Issue:11 Topics: Animals; Biomarkers; Brain; Cytochrome P450 Family 2; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mutation; Phenotype; Proteomics	2021
IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury. International immunopharmacology, 2021, Volume: 100 Topics: Acute Kidney Injury; Animals; Cell Transdifferentiation; Cells, Cultured; Cytokines; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Fibrosis; Folic Acid; Inflammation Mediators; Interferon Regulatory Factors; Kidney; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Nephritis; Renal Insufficiency, Chronic	2021
All-Trans Retinoic Acid and Doxorubicin Delivery by Folic Acid Modified Polymeric Micelles for the Modulation of Pin1-Mediated DOX-Induced Breast Cancer Stemness and Metastasis. Molecular pharmaceutics, 2021, 11-01, Volume: 18, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chitosan; Disease Models, Animal; Doxorubicin; Drug Liberation; Drug Synergism; Female; Folic Acid; Gene Knockdown Techniques; Humans; Mice; Micelles; Nanoparticle Drug Delivery System; Neoplastic Stem Cells; NIMA-Interacting Peptidylprolyl Isomerase; Tissue Distribution; Tretinoin	2021
Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses. Toxicology, 2021, Volume: 463 Topics: Adenine; Animals; Cytokines; Disease Models, Animal; Fibrosis; Folic Acid; Inflammation; Male; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic	2021
B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets. Current medical science, 2021, Volume: 41, Issue:5 Topics: Animals; Cognitive Dysfunction; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Enzymologic; Male; Morris Water Maze Test; Niacin; Pyridoxine; Rats; Riboflavin; Thiamine; Transketolase; Vitamin B 12; Vitamin B Complex	2021
Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. International journal of molecular sciences, 2021, Oct-29, Volume: 22, Issue:21 Topics: Animals; Disease Models, Animal; Fibrillin-1; Folic Acid; Humans; Marfan Syndrome; Mice; Mice, Transgenic; Mutation, Missense; Signal Transduction; Transforming Growth Factor beta	2021
Smooth muscle cells affect differential nanoparticle accumulation in disturbed blood flow-induced murine atherosclerosis. PloS one, 2021, Volume: 16, Issue:12 Topics: Animals; Apolipoproteins E; Atherosclerosis; Blood Flow Velocity; Contrast Media; Diagnosis, Differential; Disease Models, Animal; Female; Folic Acid; Gadolinium; Magnetic Resonance Imaging; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Nanoparticles; Plaque, Atherosclerotic; Shear Strength; Stress, Mechanical	2021
Bone Marrow-Derived RIPK3 Mediates Kidney Inflammation in Acute Kidney Injury. Journal of the American Society of Nephrology : JASN, 2022, Volume: 33, Issue:2 Topics: Acute Kidney Injury; Animals; Bone Marrow; Cytokine TWEAK; Disease Models, Animal; Folic Acid; Humans; Inflammation; Interleukin-6; Jurkat Cells; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Messenger; Transplantation Chimera; Up-Regulation	2022
Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis. Environmental toxicology, 2022, Volume: 37, Issue:7 Topics: Aged; Alzheimer Disease; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Folic Acid; Humans; Leucovorin; Mice; Mice, Transgenic	2022
Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy. Neuropsychopharmacology reports, 2022, Volume: 42, Issue:3 Topics: Animals; Autistic Disorder; Behavior, Animal; Depression; Disease Models, Animal; DNA; Female; Folic Acid; Humans; Mental Disorders; Methotrexate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Vitamins	2022
Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice. The Journal of nutritional biochemistry, 2022, Volume: 109 Topics: Animals; Choline; Collaborative Cross Mice; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Female; Folic Acid; Lipidomics; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Sucrose	2022
Therapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma. Drug delivery, 2022, Volume: 29, Issue:1 Topics: Adenocarcinoma of Lung; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Folic Acid; Humans; Hydroxamic Acids; Lung Neoplasms; Mice; Nanoparticles; Serum Albumin, Human	2022
Immunomodulation of MiRNA-223-based nanoplatform for targeted therapy in retinopathy of prematurity. Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 350 Topics: Animals; Chitosan; Disease Models, Animal; Folic Acid; Humans; Immunomodulation; Infant, Newborn; Inflammation; Interleukin-6; Mice; MicroRNAs; Neovascularization, Pathologic; Oxygen; Retinopathy of Prematurity; Silicon Dioxide	2022
Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer. ACS nano, 2022, 12-27, Volume: 16, Issue:12 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Folate Receptor 1; Folic Acid; Humans; Mice; Nanoparticle Drug Delivery System; Nanoparticles; Neoplasms; Silicon Dioxide	2022
Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication. Redox biology, 2022, Volume: 58 Topics: Angiotensin II; Animals; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Disease Models, Animal; Folic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Nifedipine	2022
Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and Genes, 2022, 12-17, Volume: 13, Issue:12 Topics: Animals; Disease Models, Animal; Folic Acid; Parkinson Disease; Rats; Rotenone; Vitamin B 12	2022
A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements. International journal of molecular sciences, 2023, Jan-13, Volume: 24, Issue:2 Topics: Animals; Disease Models, Animal; DNA Methylation; Folate Receptor 1; Folic Acid; Hydrocephalus; Male; Rats; Rats, Sprague-Dawley; Semen	2023
An integrated co-expression network analysis reveals novel genetic biomarkers for immune cell infiltration in chronic kidney disease. Frontiers in immunology, 2023, Volume: 14 Topics: Animals; Antigens, Neoplasm; Basic Helix-Loop-Helix Transcription Factors; Cell Adhesion Molecules; Disease Models, Animal; Folic Acid; Genes, Homeobox; Genes, Regulator; Genetic Markers; Homeodomain Proteins; Humans; Leukocytes, Mononuclear; Mice; Repressor Proteins	2023
Transbronchial real-time lung tumor localization with folate receptor-targeted near-infrared molecular imaging: A proof of concept study in animal models. The Journal of thoracic and cardiovascular surgery, 2023, Volume: 165, Issue:6 Topics: Animals; Disease Models, Animal; Folic Acid; Humans; Lung Neoplasms; Mice; Molecular Imaging; Optical Imaging; Proof of Concept Study	2023
Folic acid does not have an anti-manic effect but protect the brain against oxidative stress in an animal model of mania induced by ouabain. Journal of affective disorders, 2023, 08-01, Volume: 334 Topics: Animals; Antimanic Agents; Behavior, Animal; Brain; Disease Models, Animal; Folic Acid; Lithium; Male; Mania; Ouabain; Oxidative Stress; Rats; Rats, Wistar	2023
Combination Therapy with Resveratrol and Celastrol Using Folic Acid-Functionalized Exosomes Enhances the Therapeutic Efficacy of Sepsis. Advanced healthcare materials, 2023, Volume: 12, Issue:29 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Exosomes; Folic Acid; Lipopolysaccharides; Mice; Pentacyclic Triterpenes; Resveratrol; Sepsis	2023
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy. Neuropathology and applied neurobiology, 2023, Volume: 49, Issue:4 Topics: Alzheimer Disease; Animals; Betaine; Carbon; Choline; Dietary Supplements; Disease Models, Animal; Folic Acid; Humans; Mice; Mice, Transgenic; Phosphorylation; Protein Phosphatase 2; tau Proteins; Tauopathies	2023
Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model. EBioMedicine, 2023, Volume: 95 Topics: Animals; Disease Models, Animal; Female; Fetus; Folic Acid; Folic Acid Deficiency; HIV Infections; Humans; Incidence; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Neural Tube Defects; Ontario; Placenta; Pregnancy	2023
The loop-tail mouse model displays open and closed caudal neural tube defects. Disease models & mechanisms, 2023, 08-01, Volume: 16, Issue:8 Topics: Animals; Disease Models, Animal; DNA-Binding Proteins; Folic Acid; Mice; Microfilament Proteins; Mutation; Neural Tube Defects; rho GTP-Binding Proteins; Tail; Transcription Factors	2023
Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Doxorubicin; Female; Folic Acid; Hydrogen-Ion Concentration; Liposomes; Mice, Inbred BALB C; Neoplasm Metastasis; Tissue Distribution	2019
Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel. International journal of nanomedicine, 2019, Volume: 14 Topics: Administration, Intravesical; Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Colloids; Disease Models, Animal; Drug Liberation; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogels; Liposomes; Mice; Particle Size; Sirolimus; Temperature; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms	2019
Prenatal Exposure to Environmentally-Relevant Contaminants Perturbs Male Reproductive Parameters Across Multiple Generations that are Partially Protected by Folic Acid Supplementation. Scientific reports, 2019, 09-25, Volume: 9, Issue:1 Topics: Animals; Disease Models, Animal; Environmental Pollution; Female; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Developmental; Male; Paternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reproduction; Spermatozoa	2019
Inhibition of Kirsten-Ras reduces fibrosis and protects against renal dysfunction in a mouse model of chronic folic acid nephropathy. Scientific reports, 2019, 09-30, Volume: 9, Issue:1 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibrosis; Folic Acid; Gene Knockdown Techniques; Jagged-1 Protein; Kidney; Male; Mice; Polymerase Chain Reaction; Proto-Oncogene Proteins p21(ras); Renal Insufficiency, Chronic	2019
Imaging Rheumatoid Arthritis in Mice Using Combined Near Infrared and Scientific reports, 2019, 10-04, Volume: 9, Issue:1 Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Fluorine-19 Magnetic Resonance Imaging; Folic Acid; Mice; Nanoparticles; RAW 264.7 Cells; Spectroscopy, Near-Infrared	2019
Cellular mechanisms underlying Disease models & mechanisms, 2019, 11-22, Volume: 12, Issue:11 Topics: Animals; Apoptosis; Cell Cycle; Dietary Supplements; Disease Models, Animal; Folic Acid; Mice; Mice, Inbred C3H; Mice, Inbred CBA; Mutation; Neural Tube Defects; PAX3 Transcription Factor	2019
Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney Injury. Scientific reports, 2019, 11-13, Volume: 9, Issue:1 Topics: Animals; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Folic Acid; Gene Expression Profiling; Gene Expression Regulation; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Ureteral Obstruction; Vitamin B Complex	2019
Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of mania. Metabolic brain disease, 2020, Volume: 35, Issue:2 Topics: Amphetamine; Animals; Antimanic Agents; Central Nervous System Stimulants; Disease Models, Animal; Drug Therapy, Combination; Folic Acid; Inflammation Mediators; Lithium; Male; Mania; Oxidative Stress; Rats; Rats, Wistar; Treatment Outcome	2020
Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress. BMC neuroscience, 2020, 01-15, Volume: 21, Issue:1 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Biogenic Monoamines; Brain; Citalopram; Depression; Disease Models, Animal; Folic Acid; Homocysteine; Male; Rats, Sprague-Dawley; Stress, Psychological	2020
Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo-Chemo Combination Therapy. ACS nano, 2020, 02-25, Volume: 14, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Dopamine; Female; Folic Acid; Hyaluronic Acid; Indocyanine Green; Injections, Intravenous; Irinotecan; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Optical Imaging; Particle Size; Peptides; Rats; Rats, Wistar; Surface Properties	2020
Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate. Scientific reports, 2020, 02-06, Volume: 10, Issue:1 Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Diarylheptanoids; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Folic Acid; Glucuronidase; Humans; Kidney Tubules; Klotho Proteins; Mice; Molecular Conformation; Necrosis; NF-kappa B; Polyglutamic Acid; Protective Agents; Signal Transduction; Structure-Activity Relationship; Transcription, Genetic	2020
Effect of folate supplementation on immunological and autophagy markers in experimental nonalcoholic fatty liver disease. European cytokine network, 2019, Dec-01, Volume: 30, Issue:4 Topics: Animals; Autophagy; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Immunologic; Folic Acid; Gene Expression Regulation; Interleukin-22; Interleukin-8; Interleukins; Lipid Metabolism; Liver; Male; Microtubule-Associated Proteins; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2019
An efficient controlled release strategy for hypertension therapy: Folate-mediated lipid nanoparticles for oral peptide delivery. Pharmacological research, 2020, Volume: 157 Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Caco-2 Cells; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Drug Stability; Folic Acid; HT29 Cells; Humans; Hypertension; Intestinal Absorption; Lipids; Male; Nanoparticles; Oligopeptides; Rats, Inbred SHR; Rats, Sprague-Dawley	2020
Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. PLoS pathogens, 2020, Volume: 16, Issue:5 Topics: Animals; Disease Models, Animal; Female; Folic Acid; Human Umbilical Vein Endothelial Cells; Humans; Mice; Microcephaly; Placenta; Pregnancy; Pregnancy Complications, Infectious; Zika Virus; Zika Virus Infection	2020
Milk fermented with Lactococcus lactis KLDS4.0325 alleviates folate status in deficient mice. Food & function, 2020, May-01, Volume: 11, Issue:5 Topics: Animals; Disease Models, Animal; Female; Fermentation; Folic Acid; Folic Acid Deficiency; Functional Food; Lactococcus lactis; Mice; Mice, Inbred BALB C; Milk	2020
Ultrasound-targeted microbubble destruction augmented synergistic therapy of rheumatoid arthritis via targeted liposomes. Journal of materials chemistry. B, 2020, 06-24, Volume: 8, Issue:24 Topics: Animals; Arthritis, Experimental; Cells, Cultured; Dexamethasone; Disease Models, Animal; Female; Folic Acid; Liposomes; Mice; Molecular Structure; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Surface Properties; Ultrasonic Waves	2020
Rise in serum folate after androgen deprivation associated with worse prostate cancer-specific survival. Urologic oncology, 2020, Volume: 38, Issue:8 Topics: Aged; Aged, 80 and over; Androgen Antagonists; Animals; Disease Models, Animal; Folic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Prostatic Neoplasms; Retrospective Studies; Survival Rate	2020
Folic acid attenuates high-fat diet-induced steatohepatitis World journal of gastroenterology, 2020, May-14, Volume: 26, Issue:18 Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Disease Models, Animal; DNA, Bacterial; Feces; Folic Acid; Gastrointestinal Microbiome; Humans; Lipid Metabolism; Liver; Male; Non-alcoholic Fatty Liver Disease; PPAR alpha; Rats; RNA, Ribosomal, 16S; RNA, Small Interfering; Sirtuin 1; Up-Regulation	2020
Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2020, Volume: 62 Topics: Animals; Biological Transport; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Hepcidins; Iron; Iron Deficiencies; Liver; Membrane Transport Proteins; Minor Histocompatibility Antigens; Rats, Wistar; Receptors, Transferrin; Reduced Folate Carrier Protein	2020
RIPK3 blockade attenuates kidney fibrosis in a folic acid model of renal injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:8 Topics: Animals; Disease Models, Animal; Fibrosis; Folic Acid; Imidazoles; Inflammasomes; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Oximes; Receptor-Interacting Protein Serine-Threonine Kinases; Renal Insufficiency, Chronic	2020
Hyperhomocysteinemia: an instigating factor for periodontal disease. Canadian journal of physiology and pharmacology, 2021, Volume: 99, Issue:1 Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Transgenic; Oxidative Stress; Periodontitis; Periodontium	2021
Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD). Reproductive toxicology (Elmsford, N.Y.), 2020, Volume: 96 Topics: Abnormalities, Drug-Induced; Air Sacs; Animals; Behavior, Animal; Disease Models, Animal; Embryo, Nonmammalian; Ethanol; Eye Abnormalities; Female; Fetal Alcohol Spectrum Disorders; Folic Acid; Larva; Locomotion; Male; Sleep; Tail; Teratogens; Yolk Sac; Zebrafish	2020
Diet Alters Micronutrient Pathways in the Gut and Placenta that Regulate Fetal Growth and Development in Pregnant Mice. Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:2 Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Caloric Restriction; Diet; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Energy Intake; Female; Fetal Development; Fetal Weight; Fetus; Folic Acid; Gastrointestinal Microbiome; Gastrointestinal Tract; Inositol; Malnutrition; Maternal Nutritional Physiological Phenomena; Membrane Transport Proteins; Mice, Inbred C57BL; Nutritional Status; Nutritive Value; Obesity; Placenta; Pregnancy	2021
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats. Experimental animals, 2021, Feb-06, Volume: 70, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Folic Acid; Free Radical Scavengers; Oxidative Stress; Rats, Sprague-Dawley	2021
Tumor suppressor genes are differentially regulated with dietary folate modulations in a rat model of hepatocellular carcinoma. Molecular and cellular biochemistry, 2021, Volume: 476, Issue:1 Topics: Animal Feed; Animals; Apoptosis; Carcinoma, Hepatocellular; Core Binding Factor Alpha 3 Subunit; Diet; Disease Models, Animal; DNA Fragmentation; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Liver Neoplasms; Male; Rats; Rats, Wistar; Suppressor of Cytokine Signaling 1 Protein; Tumor Suppressor Proteins	2021
EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes & development, 2020, 11-01, Volume: 34, Issue:21-22 Topics: Animals; Carbon; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Interleukin-7; Mice; PAX5 Transcription Factor; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Protein Binding; Proto-Oncogene Proteins c-myc; Signal Transduction; Single-Cell Analysis; Trans-Activators	2020
Recent patents on anti-cancer drug discovery, 2020, Volume: 15, Issue:4 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Endosomes; Female; Fibrinolytic Agents; Folate Receptor 1; Folic Acid; Heparin; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Micelles; Nanoparticles; Neoplasms; Patents as Topic	2020
Oral delivery of folate-targeted resveratrol-loaded nanoparticles for inflammatory bowel disease therapy in rats. Life sciences, 2020, Dec-01, Volume: 262 Topics: Administration, Oral; Animals; Caco-2 Cells; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Liberation; Folic Acid; Humans; Inflammatory Bowel Diseases; Male; Nanoparticles; Permeability; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Resveratrol	2020
Evaluation of vitamin-producing and immunomodulatory lactic acid bacteria as a potential co-adjuvant for cancer therapy in a mouse model. Journal of applied microbiology, 2021, Volume: 130, Issue:6 Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Cell Line; Cell Survival; Cytokines; Disease Models, Animal; Female; Fluorouracil; Folic Acid; Humans; Immunomodulation; Intestinal Mucosa; Lactobacillales; Mice; Mice, Inbred BALB C; Mucositis; Riboflavin; Vitamins	2021
Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy. Biochemical and biophysical research communications, 2021, 01-01, Volume: 534 Topics: Animals; Disease Models, Animal; Extracellular Matrix; Fibrosis; Folic Acid; Inflammasomes; Kidney; Kidney Diseases; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Pyridones; Reactive Oxygen Species	2021
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. Molecular genetics and metabolism, 2021, Volume: 132, Issue:2 Topics: Adenosylhomocysteinase; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Enzymologic; Glycine Hydroxymethyltransferase; Homocysteine; Homocystinuria; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Polyamines	2021
In Vitro and In Vivo Efficacy of a Novel Glucose-Methotrexate Conjugate in Targeted Cancer Treatment. International journal of molecular sciences, 2021, Feb-09, Volume: 22, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Female; Folic Acid; Glucose; Glucose Transporter Type 1; Humans; Injections, Intravenous; Methotrexate; Mice	2021
Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation. Toxicology and applied pharmacology, 2021, 06-01, Volume: 420 Topics: Animals; Benzofurans; CELF1 Protein; Cell Line; Disease Models, Animal; Fibroblasts; Fibrosis; Folic Acid; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Rats; Transforming Growth Factor beta1	2021
Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury. Proceedings of the National Academy of Sciences of the United States of America, 2021, 04-20, Volume: 118, Issue:16 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibroblast Growth Factor-23; Folic Acid; Interleukin-6; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Estrogen; Transcriptional Activation	2021
Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. Food & function, 2021, May-21, Volume: 12, Issue:10 Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Social Behavior; Valproic Acid	2021
AMPK/mTOR downregulated autophagy enhances aberrant endometrial decidualization in folate-deficient pregnant mice. Journal of cellular physiology, 2021, Volume: 236, Issue:11 Topics: AMP-Activated Protein Kinases; Animals; Autophagosomes; Autophagy; Cells, Cultured; Decidua; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Lysosomes; Mice; Microtubule-Associated Proteins; Pregnancy; Signal Transduction; Stromal Cells; TOR Serine-Threonine Kinases	2021
Folate-targeted verrucarin A reduces the number of activated macrophages in a mouse model of acute peritonitis. Bioorganic & medicinal chemistry letters, 2021, 06-15, Volume: 42 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Folate Receptor 2; Folic Acid; Macrophages; Mice; Molecular Structure; Peritonitis; Structure-Activity Relationship; Trichothecenes	2021
Genetic and pharmacological inhibition of fatty acid-binding protein 4 alleviated inflammation and early fibrosis after toxin induced kidney injury. International immunopharmacology, 2021, Volume: 96 Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Biphenyl Compounds; Carcinogens; Disease Models, Animal; Fatty Acid-Binding Proteins; Fibrosis; Folic Acid; Hematinics; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; RNA, Small Interfering	2021
Folic acid alleviates the blood brain barrier permeability and oxidative stress and prevents cognitive decline in sepsis-surviving rats. Microvascular research, 2021, Volume: 137 Topics: Animals; Antioxidants; Behavior, Animal; Blood-Brain Barrier; Capillary Permeability; Cognition; Cognitive Dysfunction; Disease Models, Animal; Folic Acid; Lipid Peroxidation; Male; Memory; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Sepsis	2021
Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Biomarkers; Disease Models, Animal; Female; Folic Acid; Folic Acid Transporters; Gene Expression Regulation; Immunohistochemistry; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Rats; Reperfusion Injury	2021
Inhibition of acetic acid-induced colitis in rats by new Pediococcus acidilactici strains, vitamin producers recovered from human gut microbiota. PloS one, 2021, Volume: 16, Issue:7 Topics: Acetic Acid; Administration, Oral; Animals; Anti-Bacterial Agents; Bile Acids and Salts; Colitis; Colon; Disease Models, Animal; Feces; Folic Acid; Gastrointestinal Microbiome; Humans; Hydrogen-Ion Concentration; Male; Pediococcus acidilactici; Probiotics; Rats; Rats, Wistar; Riboflavin; RNA, Ribosomal, 16S	2021
Different Patterns of Kidney Fibrosis Are Indicative of Injury to Distinct Renal Compartments. Cells, 2021, 08-06, Volume: 10, Issue:8 Topics: Aged; Animals; Collagen; Disease Models, Animal; Extracellular Matrix; Female; Fibrosis; Folic Acid; Humans; Kidney; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Male; Mice, Inbred C57BL; Middle Aged; Nephritis; Prognosis; Retrospective Studies; Transcriptome; Ureteral Obstruction	2021
The Evaluation of Folic Acid-Deficient or Folic Acid-Supplemented Diet in the Gestational Phase of Female Rats and in Their Adult Offspring Subjected to an Animal Model of Schizophrenia. Molecular neurobiology, 2018, Volume: 55, Issue:3 Topics: Animals; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Inflammation Mediators; Ketamine; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Vitamin B Complex	2018
Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:10 Topics: Animals; Antioxidants; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cholesterol, HDL; Diet, High-Fat; Disease Models, Animal; Folic Acid; Homocysteine; Lipid Peroxidation; Male; Oxidative Stress; Plaque, Atherosclerotic; Rats, Wistar; Time Factors	2017
Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice. Theranostics, 2017, Volume: 7, Issue:7 Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chemokine CXCL10; Chitosan; Dendritic Cells; Disease Models, Animal; Drug Carriers; Folic Acid; Heterografts; Mice; Mice, Inbred C57BL; Nanoparticles; Treatment Outcome; Vaccines, DNA	2017
The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney international, 2017, Volume: 92, Issue:6 Topics: Actins; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Folic Acid; Humans; Kidney; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Monocytes; Receptors, Cell Surface; Renal Insufficiency, Chronic; Signal Transduction; STAT6 Transcription Factor; Th2 Cells	2017
Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Molecular psychiatry, 2018, Volume: 23, Issue:2 Topics: Animals; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; CA1 Region, Hippocampal; Clozapine; Developmental Disabilities; Disease Models, Animal; Female; Folic Acid; Haloperidol; Humans; Male; Methionine; Mice; Neurogenesis; Neuronal Plasticity; One-Carbon Group Transferases; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Schizophrenia; Stereotyped Behavior; Tetrahydrofolates	2018
Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain. Neuroreport, 2017, Nov-08, Volume: 28, Issue:16 Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Folic Acid; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sensorimotor Cortex; Serotonin; Stress, Psychological; Up-Regulation	2017
Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis. International journal of nanomedicine, 2017, Volume: 12 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Carriers; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Male; Methotrexate; Molecular Targeted Therapy; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Rats, Sprague-Dawley	2017
Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis. Journal of Crohn's & colitis, 2018, Jan-24, Volume: 12, Issue:2 Topics: Alginates; Animals; Biocompatible Materials; Catechols; Cell Line; Chitosan; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Drug Delivery Systems; Epithelial Cells; Folic Acid; Glucuronic Acid; Heme Oxygenase-1; Hexuronic Acids; Hydrogels; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Macrophages; Membrane Proteins; Mice; Nanoparticles; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Polyethylene Glycols; RNA, Messenger; Tumor Necrosis Factor-alpha; Wound Healing	2018
Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. American journal of physiology. Regulatory, integrative and comparative physiology, 2018, 01-01, Volume: 314, Issue:1 Topics: Animals; Cobalt; Dermatitis; Dietary Supplements; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Hypersensitivity; Immunoglobulin E; Mast Cells; Methionine; Ovalbumin; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Pyroglyphidae; Sheep, Domestic; Skin; Sulfur	2018
Effects of folic acid administration on testicular ischemia/reperfusion injury in rats. Acta cirurgica brasileira, 2017, Volume: 32, Issue:9 Topics: Animals; Disease Models, Animal; Folic Acid; Male; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Spermatozoa; Testis	2017
The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice. Environmental toxicology, 2018, Volume: 33, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Line; Disease Models, Animal; Folic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Presenilin-1; Receptors, Somatomedin; Risk Factors; Sirtuin 1; Superoxide Dismutase; tau Proteins	2018
Leukemia-specific delivery of mutant NOTCH1 targeted therapy. The Journal of experimental medicine, 2018, 01-02, Volume: 215, Issue:1 Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Endocytosis; Folate Receptor 2; Folic Acid; Gene Expression; Humans; Leukemia; Mice; Mutation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Receptor, Notch1; Signal Transduction; Thapsigargin; Xenograft Model Antitumor Assays	2018
Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation. The Journal of pathology, 2018, Volume: 244, Issue:2 Topics: Animals; Connective Tissue Growth Factor; Disease Models, Animal; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Fibroblasts; Fibrosis; Folic Acid; G2 Phase Cell Cycle Checkpoints; Humans; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; NIH 3T3 Cells; Peptide Fragments; Protein Kinase Inhibitors; Receptor, trkA; Signal Transduction; STAT3 Transcription Factor	2018
Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis. Scientific reports, 2018, 01-10, Volume: 8, Issue:1 Topics: Animals; Antineoplastic Agents; Carbohydrate Metabolism; Cell Line, Tumor; Cytoplasm; Disease Models, Animal; Folic Acid; Humans; Kaplan-Meier Estimate; Metabolic Networks and Pathways; Mitochondria; Xenograft Model Antitumor Assays	2018
Metformin attenuates folic-acid induced renal fibrosis in mice. Journal of cellular physiology, 2018, Volume: 233, Issue:9 Topics: Albuminuria; Animals; Cell Line; Chemokine CCL2; Collagen Type IV; Disease Models, Animal; Extracellular Matrix; Fibronectins; Fibrosis; Folic Acid; Gene Expression Regulation; Humans; Inflammation; Kidney; Kidney Tubules, Proximal; Male; MAP Kinase Signaling System; Metformin; Mice, Inbred C57BL; Smad3 Protein; Transforming Growth Factor beta1	2018
Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases. Nanomedicine : nanotechnology, biology, and medicine, 2018, Volume: 14, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Betamethasone; Colitis; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Folate Receptor 2; Folic Acid; Gene Expression Regulation; Liposomes; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Nanotechnology	2018
Folate Deficiency Facilitates Genomic Integration of Human Papillomavirus Type 16 DNA In Vivo in a Novel Mouse Model for Rapid Oncogenic Transformation of Human Keratinocytes. The Journal of nutrition, 2018, 03-01, Volume: 148, Issue:3 Topics: Animals; Carcinogenesis; Disease Models, Animal; DNA; Female; Folic Acid; Folic Acid Deficiency; Genome; Human papillomavirus 16; Humans; Keratinocytes; Mice, Nude; Neoplasms; Nutritional Status; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Papillomavirus Infections; Repressor Proteins; Uterine Cervical Neoplasms; Virus Integration	2018
Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals. Nanomedicine (London, England), 2018, Volume: 13, Issue:8 Topics: Animals; Anti-Retroviral Agents; Disease Models, Animal; Drug Delivery Systems; Folic Acid; HIV Infections; HIV-1; Humans; Macrophages; Mice; Nanoparticles; Pyridones; Tissue Distribution	2018
A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy. Theranostics, 2018, Volume: 8, Issue:7 Topics: Albumins; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Therapy; Flow Cytometry; Folic Acid; Heterografts; Humans; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Models, Biological; Molecular Targeted Therapy; Neoplasm Transplantation; Paclitaxel; Prodrugs; Protein Binding; Treatment Outcome; Tumor Protein, Translationally-Controlled 1	2018
The Protective Effects of Enalapril Maleate and Folic Acid Tablets against Contrast-Induced Nephropathy in Diabetic Rats. BioMed research international, 2018, Volume: 2018 Topics: Animals; Apoptosis; Blood Urea Nitrogen; Contrast Media; Creatinine; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Combinations; Enalapril; Endothelial Cells; Folic Acid; Humans; Kidney; Kidney Diseases; Nitric Oxide; Oxidative Stress; Rats	2018
Folate homeostasis in epileptic rats. Epilepsy research, 2018, Volume: 142 Topics: Animals; Brain; CD11b Antigen; Convulsants; Disease Models, Animal; Folate Receptor 1; Folic Acid; Glial Fibrillary Acidic Protein; Hippocampus; Homeostasis; Lithium; Male; Phosphopyruvate Hydratase; Pilocarpine; Proton-Coupled Folate Transporter; Rats; Rats, Wistar; Reduced Folate Carrier Protein; RNA, Messenger; Statistics, Nonparametric; Status Epilepticus	2018
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects. The Journal of nutrition, 2018, 04-01, Volume: 148, Issue:4 Topics: Animals; Congenital Abnormalities; Diet; Disease Models, Animal; DNA Methylation; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genotype; Ligases; Liver; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Multifunctional Enzymes; Placenta; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy, Animal; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	2018
Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease. American journal of physiology. Renal physiology, 2018, 08-01, Volume: 315, Issue:2 Topics: A549 Cells; Animals; Disease Models, Animal; Drug Compounding; Folate Receptor 1; Folic Acid; Humans; Integrases; Kidney; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Signal Transduction; Sirolimus; Tissue Distribution; TOR Serine-Threonine Kinases; TRPP Cation Channels	2018
In Vitro and In Vivo evaluation of a novel folate-targeted theranostic nanoemulsion of docetaxel for imaging and improved anticancer activity against ovarian cancers. Cancer biology & therapy, 2018, 07-03, Volume: 19, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Drug Carriers; Emulsions; Endocytosis; Female; Folate Receptor 1; Folic Acid; Gadolinium; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Imaging; Nanoparticles; Neoplasm Recurrence, Local; Ovarian Neoplasms; Theranostic Nanomedicine	2018
Changes in behavioural parameters, oxidative stress and neurotrophins in the brain of adult offspring induced to an animal model of schizophrenia: The effects of FA deficient or FA supplemented diet during the neurodevelopmental phase. Progress in neuro-psychopharmacology & biological psychiatry, 2018, 08-30, Volume: 86 Topics: Animals; Behavior, Animal; Brain; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Ketamine; Male; Nerve Growth Factors; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Wistar; Schizophrenia; Schizophrenic Psychology	2018
ω-3 and folic acid act against depressive-like behavior and oxidative damage in the brain of rats subjected to early- or late-life stress. Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 53 Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain; Depressive Disorder; Disease Models, Animal; Fatty Acids, Omega-3; Folic Acid; Lipid Peroxidation; Maternal Deprivation; Oxidative Stress; Rats; Rats, Wistar; Stress, Psychological	2018
Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney international, 2018, Volume: 94, Issue:2 Topics: Acute Kidney Injury; Adenine; Animals; Bone and Bones; Dexamethasone; Disease Models, Animal; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Folic Acid; Glucocorticoids; Humans; Interleukin-6; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Promoter Regions, Genetic; Receptors, Interleukin-6; Recombinant Fusion Proteins; Renal Insufficiency, Chronic; RNA, Messenger; STAT3 Transcription Factor; Transcription, Genetic	2018
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels. Journal of Alzheimer's disease : JAD, 2018, Volume: 64, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Female; Folic Acid; Glycogen Synthase Kinase 3 beta; Homocysteine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Mutation; Phosphorylation	2018
High folate intake contributes to the risk of large for gestational age birth and obesity in male offspring. Journal of cellular physiology, 2018, Volume: 233, Issue:12 Topics: Adipocytes; Adiposity; Adult; Animals; Birth Weight; Blood Glucose; Case-Control Studies; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Folic Acid; Gestational Age; Humans; Lipids; Male; Obesity; Phenotype; Pregnancy; Rats, Sprague-Dawley; Risk Factors	2018
Multifunctional nanoparticles for trimodal photodynamic therapy-mediated photothermal and chemotherapeutic effects. Photodiagnosis and photodynamic therapy, 2018, Volume: 23 Topics: Animals; Carboplatin; Cell Survival; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Drug Therapy, Combination; Folic Acid; Hydrogen-Ion Concentration; Indocyanine Green; Infrared Rays; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Polylactic Acid-Polyglycolic Acid Copolymer	2018
Effect of Homocysteine on the Differentiation of CD4 Digestive diseases and sciences, 2018, Volume: 63, Issue:12 Topics: Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Colon; Cyclooxygenase 2; Disease Models, Animal; Folic Acid; Group IV Phospholipases A2; Homocysteine; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Mucous Membrane; Nuclear Receptor Subfamily 1, Group F, Member 3; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Th17 Cells; Treatment Outcome; Vitamin B Complex	2018
CCL20 blockade increases the severity of nephrotoxic folic acid-induced acute kidney injury. The Journal of pathology, 2018, Volume: 246, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Animals; Antibodies, Neutralizing; Case-Control Studies; Cell Line; Chemokine CCL20; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Fibrosis; Folic Acid; Gene Expression Profiling; Humans; Immunity, Innate; Kidney Tubules; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Receptors, CCR6; Severity of Illness Index; Signal Transduction; Systems Biology; T-Lymphocytes, Regulatory; Th17 Cells; Young Adult	2018
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke. Experimental neurology, 2018, Volume: 309 Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Homocysteine; Male; Metabolic Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neurons; Psychomotor Performance; Recovery of Function; Stroke	2018
Improvement of symptoms in a rat model of depression through combined zinc and folic acid administration via up-regulation of the Trk B and NMDA. Neuroscience letters, 2018, 09-14, Volume: 683 Topics: Animals; Brain; Depression; Disease Models, Animal; Drug Therapy, Combination; Folic Acid; Male; N-Methylaspartate; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Up-Regulation; Zinc	2018
Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model. PloS one, 2018, Volume: 13, Issue:8 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Embryo, Nonmammalian; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Folic Acid; Nerve Tissue Proteins; Photoreceptor Cells, Vertebrate; Pregnancy; Receptors, Notch; Retina; Retinal Diseases; Tretinoin; Wnt Signaling Pathway; Zebrafish	2018
Multiparametric MRI detects longitudinal evolution of folic acid-induced nephropathy in mice. American journal of physiology. Renal physiology, 2018, 11-01, Volume: 315, Issue:5 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Disease Progression; Fibrosis; Folic Acid; Glomerular Filtration Rate; Kidney; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Necrosis; Organ Size; Predictive Value of Tests; Renal Circulation; Time Factors	2018
Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease. Scientific reports, 2018, 08-15, Volume: 8, Issue:1 Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Cisplatin; Disease Models, Animal; Female; Fibrosis; Folic Acid; Kidney; Kidney Diseases; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Renal Insufficiency, Chronic	2018
Formate Supplementation May Prevent Some Neural Tube Defects that Prove Resistant to Folic Acid: Supplementation with formate rescued normal neural tube closure in more than three quarters of the embryos of novel folic acid-resistant neural tube defect mo American journal of medical genetics. Part A, 2018, Volume: 176, Issue:8 Topics: Aminohydrolases; Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Formate-Tetrahydrofolate Ligase; Formates; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Multienzyme Complexes; Neural Tube; Neural Tube Defects	2018
Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina. Neuroscience bulletin, 2019, Volume: 35, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Rats, Sprague-Dawley; Retina; Retinal Vessels; tau Proteins; Vitamin B 12	2019
Targeting enhancer of zeste homolog 2 protects against acute kidney injury. Cell death & disease, 2018, 10-19, Volume: 9, Issue:11 Topics: Acute Kidney Injury; Adenosine; Adherens Junctions; Animals; Apoptosis; Cadherins; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Folic Acid; Hydrogen Peroxide; Jumonji Domain-Containing Histone Demethylases; Kidney; Kidney Tubules; Lipocalin-2; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Phosphatidylethanolamine Binding Protein; Phosphorylation; Proto-Oncogene Proteins c-raf; Reperfusion Injury; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Zonula Occludens-1 Protein	2018
Surface-Modified Nanoerythrocyte Loading DOX for Targeted Liver Cancer Chemotherapy. Molecular pharmaceutics, 2018, 12-03, Volume: 15, Issue:12 Topics: Administration, Intravenous; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Doxorubicin; Drug Compounding; Drug Delivery Systems; Drug Liberation; Drug Screening Assays, Antitumor; Erythrocytes; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Tissue Distribution	2018
Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer. Nutrition and cancer, 2019, Volume: 71, Issue:1 Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Folic Acid; Glutathione; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin B 12	2019
Biometric Alterations of Mouse Embryonic Eye Structures Due to Short-Term Folic Acid Deficiency. Current eye research, 2019, Volume: 44, Issue:4 Topics: Animals; Biometry; Diet; Disease Models, Animal; Embryonic Development; Eye Abnormalities; Female; Folic Acid; Folic Acid Deficiency; Maternal Exposure; Mice; Mice, Inbred C57BL; Pregnancy	2019
Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free radical biology & medicine, 2019, Volume: 130 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Disease Models, Animal; Energy Metabolism; Folic Acid; Glutathione; Humans; Mitochondria; Mitochondrial Dynamics; Oxidative Stress; Protein Processing, Post-Translational; Rats	2019
Supplementation with dairy matrices impacts on homocysteine levels and gut microbiota composition of hyperhomocysteinemic mice. European journal of nutrition, 2020, Volume: 59, Issue:1 Topics: Animals; Diet; Disease Models, Animal; Fermented Foods; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Milk	2020
Surface functionalized folate targeted oleuropein nano-liposomes for prostate tumor targeting: Invitro and invivo activity. Life sciences, 2019, Mar-01, Volume: 220 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Liberation; Folic Acid; Humans; Iridoid Glucosides; Iridoids; Liposomes; Male; Mice; Mice, Inbred BALB C; Particle Size; Prostatic Neoplasms	2019
Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis. Toxicology and applied pharmacology, 2019, 04-01, Volume: 368 Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Folate Receptor 2; Folic Acid; Humans; Liver; Macrophages; Male; Methionine; Mice, Inbred C57BL; Molecular Imaging; Non-alcoholic Fatty Liver Disease; Organotechnetium Compounds; Predictive Value of Tests; Radiopharmaceuticals; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon	2019
Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid. International journal of molecular sciences, 2019, Feb-23, Volume: 20, Issue:4 Topics: Animals; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Growth and Development; Homocysteine; Methylation; MicroRNAs; Nervous System; Pregnancy; Rats, Wistar; Vitamin B 12	2019
Subacute oral administration of folic acid elicits anti-inflammatory response in a mouse model of allergic dermatitis. The Journal of nutritional biochemistry, 2019, Volume: 67 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Cell Proliferation; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Folic Acid; Humans; Keratinocytes; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes; Toxicity Tests, Subacute	2019
Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration. Kidney international, 2019, Volume: 95, Issue:5 Topics: Acute Kidney Injury; Animals; Apoptosis; beta Catenin; Cell Proliferation; Cell Survival; Disease Models, Animal; Epithelial Cells; Fas Ligand Protein; Folic Acid; Humans; Kidney Tubules; Matrix Metalloproteinase 7; Mice; Mice, Knockout; Proteolysis; Regeneration; Reperfusion Injury; Signal Transduction	2019
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin. Cell death & disease, 2019, 03-25, Volume: 10, Issue:4 Topics: Activating Transcription Factor 4; Animals; Axonal Transport; Charcot-Marie-Tooth Disease; Disease Models, Animal; Down-Regulation; Drosophila; Drosophila Proteins; Folic Acid; Locomotion; Male; Membrane Proteins; Mitochondria; Phenotype; Reactive Oxygen Species; RNA Interference	2019
Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. European journal of pharmacology, 2019, Jun-15, Volume: 853 Topics: Animals; Arthritis, Experimental; Collagen; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Male; Methotrexate; Mice; Polyglutamic Acid	2019
PGC-1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI. The Journal of pathology, 2019, Volume: 249, Issue:1 Topics: Acute Kidney Injury; Animals; Cell Death; Cell Line; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Folic Acid; Humans; Inflammation Mediators; Kidney; Lipocalin-2; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Nephritis, Interstitial; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Severity of Illness Index; Signal Transduction	2019
Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one-carbon cycle in Wistar rats. BioFactors (Oxford, England), 2019, Volume: 45, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium; Cyclooxygenase 2; Cystathionine beta-Synthase; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; Group II Phospholipases A2; Homocysteine; Humans; Malondialdehyde; Parathyroid Hormone; Phosphates; Placenta; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Thromboxane B2; Vitamin B 12; Vitamin D Deficiency	2019
Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model. Human reproduction (Oxford, England), 2019, 05-01, Volume: 34, Issue:5 Topics: Administration, Oral; Animals; Congenital Abnormalities; Dietary Supplements; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Folic Acid; Genetic Loci; Genomic Imprinting; Humans; Male; Mice; Pregnancy; Reproductive Techniques, Assisted	2019
The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress. Ophthalmic research, 2019, Volume: 62, Issue:2 Topics: Analysis of Variance; Animals; Biomarkers; Diabetic Retinopathy; Disease Models, Animal; Female; Folic Acid; Glycated Hemoglobin; Inflammation; Insulin; Interleukin-1beta; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Oxidative Stress; Retina; Vascular Endothelial Growth Factor A	2019
Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN. EBioMedicine, 2019, Volume: 43 Topics: Anesthesia; Animals; Biomarkers; Cognitive Dysfunction; Computational Biology; Demyelinating Diseases; Disease Models, Animal; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Genome; Genomics; Macaca mulatta; Male; Maze Learning; Mice; Myelin Sheath; Signal Transduction; Thymidylate Synthase	2019
Low Maternal Dietary Folate Alters Retrotranspose by Methylation Regulation in Intrauterine Growth Retardation (IUGR) Fetuses in a Mouse Model. Medical science monitor : international medical journal of experimental and clinical research, 2019, May-07, Volume: 25 Topics: Animals; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Folic Acid; Folic Acid Deficiency; Long Interspersed Nucleotide Elements; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates	2019
Synthesis of Anticancer research, 2019, Volume: 39, Issue:5 Topics: Acetates; Animals; Chelating Agents; Chitosan; Disease Models, Animal; Female; Folate Receptor 1; Folic Acid; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Magnetic Resonance Imaging; Mice; Nanoparticles; Ovarian Neoplasms; Polyglutamic Acid; Positron-Emission Tomography	2019
Folic acid improves abnormal behavior via mitigation of oxidative stress, inflammation, and ferroptosis in the BTBR T+ tf/J mouse model of autism. The Journal of nutritional biochemistry, 2019, Volume: 71 Topics: Animals; Autistic Disorder; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Ferroptosis; Folic Acid; Hippocampus; Inflammation; Male; Memory; Methylenetetrahydrofolate Reductase (NADPH2); Mice, Inbred C57BL; Oxidative Stress; Social Behavior	2019
GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition. Redox biology, 2019, Volume: 26 Topics: Acute Kidney Injury; Animals; Antioxidants; Biomarkers; Biopsy; Disease Models, Animal; Disease Progression; Disease Susceptibility; Folic Acid; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Kelch-Like ECH-Associated Protein 1; Lithium; Male; Mice; NF-E2-Related Factor 2; Renal Insufficiency, Chronic	2019
The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice. Developmental dynamics : an official publication of the American Association of Anatomists, 2019, Volume: 248, Issue:10 Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Embryo Culture Techniques; Female; Folate Receptor 1; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mutation; Neural Tube Defects; Pregnancy; Teratogenesis	2019
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:6 Topics: Animals; Carbon; Choline; Choline Deficiency; Cystathionine beta-Synthase; Disease Models, Animal; Down-Regulation; Fatty Liver; Folic Acid; Folic Acid Deficiency; Humans; Liver; Male; Methionine Adenosyltransferase; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred Strains; Non-alcoholic Fatty Liver Disease; Species Specificity	2013
Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus. Arthritis and rheumatism, 2013, Volume: 65, Issue:7 Topics: Animals; Antibodies, Antinuclear; Betaine; CD40 Ligand; Choline; Coenzymes; Diet; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gene Silencing; Genetic Predisposition to Disease; Lupus Erythematosus, Systemic; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronutrients; Riboflavin; Vitamin B 12; Vitamin B 6; Zinc	2013
Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials, 2013, Volume: 34, Issue:21 Topics: Animals; Cell Death; Cell Line, Tumor; Dendrimers; Disease Models, Animal; Folic Acid; Gold; Humans; Magnetic Resonance Imaging; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Particle Size; Signal-To-Noise Ratio; Spectrophotometry, Ultraviolet; Tissue Distribution; Tomography, X-Ray Computed; X-Rays	2013
Use of folate-conjugated imaging agents to target alternatively activated macrophages in a murine model of asthma. Molecular pharmaceutics, 2013, May-06, Volume: 10, Issue:5 Topics: Animals; Arginase; Asthma; Diagnostic Imaging; Disease Models, Animal; Female; Fluorescent Dyes; Folate Receptor 2; Folic Acid; Humans; Lectins, C-Type; Lung; Macrophage Activation; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Oligopeptides; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Cell Surface; Technetium	2013
Lower concentrations of B-vitamin subgroups in the serum and amniotic fluid correlate to cleft lip and palate appearance in the offspring of A/WySn mice. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2013, Volume: 71, Issue:9 Topics: Adenine; Alkaline Phosphatase; Amniotic Fluid; Animals; Chromatography, High Pressure Liquid; Cleft Lip; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Immunohistochemistry; Indicators and Reagents; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Niacinamide; Nitroblue Tetrazolium; Palate; Pantothenic Acid; Pregnancy; Riboflavin; Thiamine; Vitamin B 6; Vitamin B Complex	2013
Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney international, 2013, Volume: 84, Issue:4 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Animals; Biomarkers; Case-Control Studies; Cohort Studies; Disease Models, Animal; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Folic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Parathyroid Hormone; Phosphates; Prospective Studies; Signal Transduction; Time Factors; Vitamin D	2013
The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects. Journal of pregnancy, 2013, Volume: 2013 Topics: Animals; Birds; Cell Differentiation; Dietary Supplements; Disease Models, Animal; Ethanol; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Heart; Heart Defects, Congenital; Homocysteine; Humans; Lithium Compounds; Maternal Exposure; Mice; Myocytes, Cardiac; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Signal Transduction; Wnt Proteins	2013
Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model. Nutrition research (New York, N.Y.), 2013, Volume: 33, Issue:6 Topics: Absorption; Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Disease Models, Animal; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Physical Conditioning, Animal	2013
Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: role of Ca2+/calmodulin-activated protein kinase II. Free radical biology & medicine, 2013, Volume: 65 Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Folic Acid; Insulin Resistance; Mice; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Nitric Oxide Synthase; Ryanodine Receptor Calcium Release Channel; Vitamin B Complex	2013
Role of methotrexate exposure in apoptosis and proliferation during early neurulation. Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:8 Topics: Animals; Apoptosis; Caspase 3; Cell Proliferation; Disease Models, Animal; Down-Regulation; Embryonic Development; Epithelial Cells; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Histones; Methotrexate; Mice; Mice, Inbred C57BL; Microarray Analysis; Neural Tube Defects; Neurulation; Pregnancy; Tetrahydrofolate Dehydrogenase; Up-Regulation	2014
Perigestational dietary folic acid deficiency protects against medulloblastoma formation in a mouse model of nevoid basal cell carcinoma syndrome. Nutrition and cancer, 2013, Volume: 65, Issue:6 Topics: Animals; Basal Cell Nevus Syndrome; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Male; Maternal Nutritional Physiological Phenomena; Medulloblastoma; Mice; Mice, Inbred C57BL; Mutation; Patched Receptors; Patched-1 Receptor; Pregnancy; Receptors, Cell Surface	2013
Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse. Brain : a journal of neurology, 2013, Volume: 136, Issue:Pt 9 Topics: Animals; Body Patterning; Cell Proliferation; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Histones; Litter Size; Male; Maternal Exposure; Mice; Mice, Mutant Strains; Neural Tube Defects; Pregnancy; Purine Nucleosides; Pyrimidine Nucleosides; Statistics, Nonparametric; Thymidine	2013
Dietary factors modulate Helicobacter-associated gastric cancer in rodent models. Toxicologic pathology, 2014, Volume: 42, Issue:1 Topics: Animals; Ascorbic Acid; Developing Countries; Diet; Dietary Fats; Disease Models, Animal; Folic Acid; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Mice; Salts; Stomach Neoplasms	2014
Neuroprotective effects of folic acid on experimental diabetic peripheral neuropathy. Toxicology and industrial health, 2016, Volume: 32, Issue:5 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Female; Folic Acid; Lipid Peroxidation; Malondialdehyde; Nerve Growth Factors; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sciatic Nerve	2016
Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice. PloS one, 2013, Volume: 8, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Cytokines; Dietary Supplements; Disease Models, Animal; Enzyme Activation; Female; Fetal Death; Fetal Growth Retardation; Folic Acid; Humans; Inflammation Mediators; Lipopolysaccharides; Male; Mice; NF-kappa B; Nitric Oxide; Placenta; Pregnancy; Premature Birth; Protective Agents; Trophoblasts	2013
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity. The Journal of nutrition, 2014, Volume: 144, Issue:4 Topics: Animals; Azoxymethane; Carcinogenesis; Choline Deficiency; Colon; Colonic Neoplasms; Crosses, Genetic; Disease Models, Animal; DNA; Extracellular Matrix Proteins; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; Male; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Proteins; Protein-Lysine 6-Oxidase; Random Allocation; Thymidine Monophosphate; Tumor Burden; Uracil	2014
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects. Developmental neurobiology, 2014, Volume: 74, Issue:9 Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates	2014
Fumonisin B₁ induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. Molecular nutrition & food research, 2014, Volume: 58, Issue:6 Topics: Animals; Diet; Disease Models, Animal; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Fumonisins; Maternal Nutritional Physiological Phenomena; Mice; Mice, Inbred Strains; Neural Tube Defects	2014
Folate receptor–targeted single-photon emission computed tomography/computed tomography to detect activated macrophages in atherosclerosis: can it distinguish vulnerable from stable atherosclerotic plaques? Molecular imaging, 2014, Volume: 13 Topics: Animals; Apolipoproteins E; Atherosclerosis; Coordination Complexes; Disease Models, Animal; Female; Folate Receptor 2; Folic Acid; Humans; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon	2014
Class I HDAC activity is required for renal protection and regeneration after acute kidney injury. American journal of physiology. Renal physiology, 2014, Aug-01, Volume: 307, Issue:3 Topics: Acute Kidney Injury; Animals; Cell Proliferation; Cell Survival; Disease Models, Animal; Epithelial Cells; ErbB Receptors; Folic Acid; Histone Deacetylases; Isoenzymes; Kidney; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt; Regeneration; Rhabdomyolysis; STAT3 Transcription Factor	2014
A critical role of noggin in developing folate-nonresponsive NTD in Fkbp8 -/- embryos. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014, Volume: 30, Issue:8 Topics: Animals; Carrier Proteins; Cell Proliferation; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Gene Expression Regulation, Developmental; Homeodomain Proteins; Humans; Jumonji Domain-Containing Histone Demethylases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Stem Cells; Neural Tube Defects; Pregnancy; Tacrolimus Binding Proteins	2014
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency. Proteomics, 2014, Volume: 14, Issue:21-22 Topics: Animals; Carcinogenesis; Diet; Disease Models, Animal; Female; Folic Acid; Homocystinuria; Intestinal Mucosa; Intestinal Neoplasms; Intestines; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Muscle Spasticity; Proteome; Proteomics; Psychotic Disorders	2014
Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defects. Birth defects research. Part A, Clinical and molecular teratology, 2014, Volume: 100, Issue:8 Topics: Animals; Disease Models, Animal; Folic Acid; Glutathione; Low Density Lipoprotein Receptor-Related Protein-6; Metabolome; Mice; Mice, Knockout; Neural Tube; Neural Tube Defects; Oxidation-Reduction; Oxidative Stress; Spinal Dysraphism	2014
Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat. Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 142, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Folic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methotrexate; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Sprague-Dawley; Tissue Distribution	2014
Does dietary folic acid supplementation in mouse NTD models affect neural tube development or gamete preference at fertilization? BMC genetics, 2014, Aug-27, Volume: 15 Topics: Alleles; Animals; Apolipoprotein B-100; Apolipoproteins B; Diet; Disease Models, Animal; Embryo Loss; Female; Fertilization; Folic Acid; Germ Cells; Inheritance Patterns; Male; Mice; Mutation; Nerve Tissue Proteins; Neural Tube; Neural Tube Defects; Phenotype	2014
Folic acid prevented cognitive impairment in experimental pneumococcal meningitis. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:5 Topics: Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Folic Acid; Frontal Lobe; Hippocampus; Inhibition, Psychological; Male; Memory; Meningitis, Pneumococcal; Motor Activity; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Random Allocation; Rats, Wistar	2015
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. Arteriosclerosis, thrombosis, and vascular biology, 2015, Volume: 35, Issue:1 Topics: Angiotensin II; Animals; Binding Sites; CCCTC-Binding Factor; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; DNA Methylation; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Mice, Inbred C57BL; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; S-Adenosylmethionine; Sp1 Transcription Factor; Telomerase; Telomere; Telomere Shortening; Time Factors; Transfection; Tumor Suppressor Protein p53	2015
[Tetrachlorodibenzo-p-dioxin-induced cleft palate because of partial loss of cell polarity to interfere with apoptosis during early developmental stage]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2014, Volume: 49, Issue:12 Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; Biomarkers; Cell Polarity; Cleft Palate; Disease Models, Animal; Female; Fetus; Folic Acid; Mice; Mice, Inbred C57BL; Polychlorinated Dibenzodioxins; Pregnancy; Receptors, Aryl Hydrocarbon; RNA, Messenger; Teratogens; Transforming Growth Factor beta3	2014
The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects. The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:4 Topics: Animals; Congenital Abnormalities; Disease Models, Animal; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Homocysteine; Mice; Neural Tube; Neural Tube Defects	2015
Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm. Journal of molecular and cellular cardiology, 2015, Volume: 81 Topics: Adventitia; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Calcium Phosphates; Carrier Proteins; Caspase 1; Disease Models, Animal; Fibroblasts; Folic Acid; Gene Expression; Hyperhomocysteinemia; Inflammasomes; Interleukin-1beta; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Rats; Reactive Oxygen Species; RNA, Small Interfering	2015
Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism. PloS one, 2015, Volume: 10, Issue:3 Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; DNA Methylation; Embryonic Development; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Methotrexate; Mice; Neural Tube Defects; Pregnancy; Protein Serine-Threonine Kinases; Tandem Mass Spectrometry; Ubiquitin-Protein Ligases; Wnt Signaling Pathway	2015
Folic acid supplementation rescues anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinson's disease. Biochemical and biophysical research communications, 2015, May-08, Volume: 460, Issue:3 Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Drosophila Proteins; Folic Acid; Gene Knockdown Techniques; Parkinson Disease; Serotonergic Neurons; Ubiquitin-Protein Ligases	2015
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects. The American journal of clinical nutrition, 2015, Volume: 101, Issue:4 Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; HeLa Cells; Humans; Maternal Nutritional Physiological Phenomena; Mice; Neural Tube; Neural Tube Defects; Pregnancy; Thymidine; Uracil; Uridine	2015
Fitting homocysteine to disease models, as well as adjusting the models to the disease. Journal of molecular medicine (Berlin, Germany), 2015, Volume: 93, Issue:6 Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidative Stress; Risk Factors; Signal Transduction; Vitamin B 12	2015
Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice. The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:8 Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Gene Silencing; Hippocampus; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Presenilin-1; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA	2015
Folic Acid Supplementation Ameliorates Oxidative Stress, Metabolic Functions and Developmental Anomalies in a Novel Fly Model of Parkinson's Disease. Neurochemical research, 2015, Volume: 40, Issue:7 Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Drosophila; Folic Acid; Humans; Introns; Locomotion; Oxidative Stress; Parkinson Disease; RNA, Messenger; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases	2015
Urate synthesis and oxidative stress in phenytoin hepatotoxicity: the role of antioxidant vitamins. Pakistan journal of biological sciences : PJBS, 2014, Volume: 17, Issue:11 Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Folic Acid; Liver; Oxidative Stress; Phenytoin; Rats, Wistar; Superoxides; Uric Acid; Vitamin E; Xanthine Oxidase	2014
Folate ameliorates dexamethasone-induced fetal and placental growth restriction potentially via improvement of trophoblast migration. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Movement; Dexamethasone; Disease Models, Animal; Female; Fetal Growth Retardation; Folic Acid; Humans; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Real-Time Polymerase Chain Reaction; Trophoblasts	2015
The effect of subchronic supplementation with folic acid on homocysteine induced seizures. Acta physiologica Hungarica, 2015, Volume: 102, Issue:2 Topics: Animals; Behavior, Animal; Brain; Brain Waves; Dietary Supplements; Disease Models, Animal; Electroencephalography; Folic Acid; Homocysteine; Male; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Up-Regulation	2015
Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells. European journal of nutrition, 2016, Volume: 55, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Presenilin-1; Promoter Regions, Genetic	2016
Fischer 344 Rat: A Preclinical Model for Epithelial Ovarian Cancer Folate-Targeted Therapy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2015, Volume: 25, Issue:7 Topics: Animals; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Proliferation; Disease Models, Animal; Female; Fluorescent Antibody Technique; Folate Receptor 1; Folic Acid; Humans; Immunoenzyme Techniques; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Peritoneal Neoplasms; Photosensitizing Agents; Rats; Rats, Inbred F344; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2015
The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia. American journal of physiology. Renal physiology, 2016, Feb-01, Volume: 310, Issue:3 Topics: Acute Kidney Injury; Adenine; Animals; Chronic Disease; Disease Models, Animal; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Folic Acid; Male; Mice, Inbred C57BL; Osteocytes; Parathyroid Hormone; Phosphorus, Dietary; Pyrimidines; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; RNA, Messenger; Skull; Up-Regulation; Uremia	2016
MRL/MpJ mice show unique pathological features after experimental kidney injury. Histology and histopathology, 2016, Volume: 31, Issue:2 Topics: Acute Kidney Injury; Animals; Calcinosis; Disease Models, Animal; Fibrosis; Folic Acid; Kidney; Kidney Diseases; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenotype; Transforming Growth Factor beta1; Wound Healing	2016
Is it possible folic acid reduce anorectal malformations ethylenethiourea induced in rats? Acta cirurgica brasileira, 2015, Volume: 30, Issue:8 Topics: Anal Canal; Animals; Anorectal Malformations; Anus, Imperforate; Disease Models, Animal; Ethylenethiourea; Female; Fetus; Folic Acid; Pregnancy; Random Allocation; Rats, Wistar; Rectum; Reproducibility of Results; Vitamin B Complex	2015
Adipose Tissue-Derived Stem Cells Reduce Acute and Chronic Kidney Damage in Mice. PloS one, 2015, Volume: 10, Issue:11 Topics: Acute Kidney Injury; Adipose Tissue; Animals; Cells, Cultured; Chronic Disease; Disease Models, Animal; Folic Acid; Kidney; Male; Mice; Stem Cell Transplantation; Stem Cells; Urea	2015
Folic Acid Alters Methylation Profile of JAK-STAT and Long-Term Depression Signaling Pathways in Alzheimer's Disease Models. Molecular neurobiology, 2016, Volume: 53, Issue:9 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; DNA Methylation; Folic Acid; Humans; Janus Kinases; Long-Term Synaptic Depression; Male; Mice, Transgenic; Reproducibility of Results; Signal Transduction; STAT Transcription Factors	2016
Effect of folic acid in a modified experimental model of anorectal malformations adriamycin-induced in rats. Acta cirurgica brasileira, 2016, Volume: 31, Issue:1 Topics: Animals; Anorectal Malformations; Anus, Imperforate; Disease Models, Animal; Doxorubicin; Epithelium; Female; Fetus; Folic Acid; Pregnancy; Random Allocation; Rats, Wistar; Topoisomerase II Inhibitors	2016
Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy. Molecular medicine reports, 2016, Volume: 13, Issue:3 Topics: Animals; Cell Membrane; Crystallization; Disease Models, Animal; Endocytosis; Folic Acid; Kidney Diseases; Male; Organic Anion Transport Protein 1; Protein Transport; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Uric Acid	2016
NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines. Cancer immunology research, 2016, Volume: 4, Issue:4 Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Cell Line, Tumor; Cytokines; Cytotoxicity, Immunologic; Disease Models, Animal; Female; Folate Receptor 1; Folic Acid; Gene Expression; Humans; Immunoconjugates; Immunoglobulin G; Immunomodulation; Interleukin-12; Killer Cells, Natural; Lymphocyte Activation; Mice; Monocytes; Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays	2016
Multi-functionalized carbon dots as theranostic nanoagent for gene delivery in lung cancer therapy. Scientific reports, 2016, Feb-16, Volume: 6 Topics: Animals; Biocompatible Materials; Carbon; Cell Line, Tumor; Disease Models, Animal; Folic Acid; Gene Expression; Gene Silencing; Gene Transfer Techniques; Genes, Reporter; Humans; Imines; Lung Neoplasms; Male; Materials Testing; Mice; Molecular Imaging; Nanoparticles; Oxidation-Reduction; Particle Size; Polyethylenes; RNA, Small Interfering; Theranostic Nanomedicine; Transgenes	2016
Cellular Uptake and Intra-Organ Biodistribution of Functionalized Silica-Coated Gold Nanorods. Molecular imaging and biology, 2016, Volume: 18, Issue:5 Topics: Animals; Cell Survival; Disease Models, Animal; Endocytosis; Folic Acid; Gold; Hep G2 Cells; Humans; Liver Neoplasms; Luminescence; Male; Nanotubes; Photons; Rabbits; Silicon Dioxide; Spectrometry, X-Ray Emission; Tissue Distribution; Tomography, X-Ray Computed	2016
Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth defects research. Part A, Clinical and molecular teratology, 2016, Volume: 106, Issue:3 Topics: Animals; Autoantibodies; Blood Proteins; Diet; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Mice; Mice, Inbred C57BL; Neural Tube Defects; Pregnancy; Protein Processing, Post-Translational	2016
Augmentation of effect of venlafaxine by folic acid in behavioral paradigms of depression in mice: Evidence of serotonergic and pro-inflammatory cytokine pathways. Pharmacological reports : PR, 2016, Volume: 68, Issue:2 Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; Folic Acid; Hindlimb Suspension; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Motor Activity; Norepinephrine; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming; Venlafaxine Hydrochloride	2016
Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects. Biochimie, 2016, Volume: 126 Topics: Animals; Disease Models, Animal; Folic Acid; Formates; Mice; Nucleotides; Spinal Dysraphism	2016
Folate-modified Chitosan Nanoparticles Containing the IP-10 Gene Enhance Melanoma-specific Cytotoxic CD8(+)CD28(+) T Lymphocyte Responses. Theranostics, 2016, Volume: 6, Issue:5 Topics: Adoptive Transfer; Animals; CD28 Antigens; CD8-Positive T-Lymphocytes; Chemokine CXCL10; Chitosan; Cytotoxicity, Immunologic; Disease Models, Animal; Drug Carriers; Folic Acid; Melanoma; Mice; Nanoparticles; Survival Analysis; Treatment Outcome	2016
Low and high dietary folic acid levels perturb postnatal cerebellar morphology in growing rats. The British journal of nutrition, 2016, Volume: 115, Issue:11 Topics: Animals; Animals, Newborn; Brain Diseases; Cerebellum; Diet; Dietary Supplements; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Male; Nutritional Status; Rats, Sprague-Dawley; Vitamin B Complex	2016
Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease. PloS one, 2016, Volume: 11, Issue:5 Topics: Acute Kidney Injury; Adult; Animals; Chromatography, Liquid; Disease Models, Animal; Folic Acid; Humans; Kidney; Kidney Diseases; Lupus Nephritis; Male; Mice; Receptors, Tumor Necrosis Factor; Reperfusion Injury; Solubility; Tandem Mass Spectrometry; TWEAK Receptor; Up-Regulation	2016
Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil. Nutrition and cancer, 2016, Volume: 68, Issue:5 Topics: Animals; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug Interactions; Epithelial Cells; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; HCT116 Cells; Homocysteine; Humans; Male; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Xenograft Model Antitumor Assays	2016
High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide. Molecular cancer therapeutics, 2016, Volume: 15, Issue:8 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Computational Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression; Gene Expression Profiling; Humans; Mice; Platinum; RNA, Messenger; Vinca Alkaloids; Xenograft Model Antitumor Assays	2016
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury. Scientific reports, 2016, 06-07, Volume: 6 Topics: Acute Kidney Injury; Animals; Apoptosis; Cathepsin D; Cell Line; Disease Models, Animal; Folic Acid; Humans; Kidney Function Tests; Kidney Tubules; Male; Mice; Nephrosis; Pepstatins; Reperfusion Injury; Up-Regulation	2016
Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles. Scientific reports, 2016, 06-08, Volume: 6 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Docetaxel; Folic Acid; G2 Phase Cell Cycle Checkpoints; Humans; Ligands; Male; Mice; Molecular Imaging; Molecular Targeted Therapy; Nanoparticles; Neoplasms; Polyethylene Glycols; Polymers; Taxoids; Xenograft Model Antitumor Assays	2016
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. Journal of neuroinflammation, 2016, 06-27, Volume: 13, Issue:1 Topics: Aneurysm, Ruptured; Animals; Arteries; Blood Pressure; Cysteine; Cytokines; Disease Models, Animal; Female; Folic Acid; Hyperhomocysteinemia; Matrix Metalloproteinase 9; Methionine; NADPH Oxidase 4; NADPH Oxidases; Ovariectomy; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Vitamin B Complex	2016
Effect of folic acid on oxidative stress and behavioral changes in the animal model of schizophrenia induced by ketamine. Journal of psychiatric research, 2016, Volume: 81 Topics: Animals; Attention Deficit and Disruptive Behavior Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Folic Acid; Interpersonal Relations; Ketamine; Lipid Metabolism; Locomotion; Male; Malondialdehyde; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Schizophrenia; Superoxide Dismutase; Time Factors; Vitamin B Complex	2016
Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice. Journal of Alzheimer's disease : JAD, 2016, 08-04, Volume: 54, Issue:1 Topics: Animals; Avoidance Learning; Cerebral Cortex; Choline; Dietary Supplements; Disease Models, Animal; Folic Acid; Glycogen Synthase Kinase 3 beta; Hippocampus; Homocysteine; Hypoxia; Male; Maze Learning; Memory; Memory Disorders; Mice; Phosphorylation; tau Proteins; Vitamin B 12; Vitamin B 6; Vitamin B Complex	2016
Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice. Nutrients, 2016, Sep-09, Volume: 8, Issue:9 Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Male; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred C57BL; MicroRNAs; Presenilin-1; RNA, Messenger	2016
Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. Scientific reports, 2016, 09-20, Volume: 6 Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Folic Acid; Humans; Liposomes; Male; Metallothionein; Mice; Models, Biological; Phosphatidylethanolamines; Prostatic Neoplasms; Sarcosine; Tumor Burden; Xenograft Model Antitumor Assays; Zinc	2016
Immune activity and biodistribution of polypeptide K237 and folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles radiolabeled with 99mTc. Oncotarget, 2016, 11-22, Volume: 7, Issue:47 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Folic Acid; Humans; Isotope Labeling; Male; Mice; Nanoparticles; Neoplasms; Oligopeptides; Organotechnetium Compounds; Polyethylene Glycols; Polyglactin 910; Tissue Distribution; Xenograft Model Antitumor Assays	2016
The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects. Nutrition journal, 2016, 11-03, Volume: 15, Issue:1 Topics: Acetyl-CoA C-Acetyltransferase; Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Regulation; Gene Silencing; Histones; Male; Neural Tube Defects; Rats; Rats, Sprague-Dawley; Tretinoin	2016
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects. Birth defects research, 2017, 01-30, Volume: 109, Issue:2 Topics: Amino Acids; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Lipids; Male; Metabolome; Mice; Neural Tube; Neural Tube Defects; Neurulation; Penetrance; Pregnancy; Purines; Pyrimidines; Teratogens; Valproic Acid	2017
Cobalamin and folate protect mitochondrial and contractile functions in a murine model of cardiac pressure overload. Journal of molecular and cellular cardiology, 2017, Volume: 102 Topics: Animals; Biomarkers; Cells, Cultured; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Folic Acid; Heart Failure; Hyperhomocysteinemia; Mice; Mitochondria, Heart; Models, Biological; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Oxidative Stress; Vitamin B 12	2017
Prevention of neural tube defects in Lrp2 mutant mouse embryos by folic acid supplementation. Birth defects research, 2017, 01-20, Volume: 109, Issue:1 Topics: Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Iron; LDL-Receptor Related Proteins; Lipoproteins; Low Density Lipoprotein Receptor-Related Protein-2; Mice; Mice, Knockout; Neural Tube; Neural Tube Defects	2017
Folate-Hapten-Mediated Immunotherapy Synergizes with Vascular Endothelial Growth Factor Receptor Inhibitors in Treating Murine Models of Cancer. Molecular cancer therapeutics, 2017, Volume: 16, Issue:3 Topics: Animals; Antineoplastic Agents; Axitinib; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Female; Folic Acid; Haptens; Humans; Imidazoles; Immunotherapy; Indazoles; Mice; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; T-Lymphocyte Subsets; Tumor Burden; Xenograft Model Antitumor Assays	2017
Folate-Targeted Surface-Enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detection of Microscopic Ovarian Cancer. ACS nano, 2017, 02-28, Volume: 11, Issue:2 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; Folic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Molecular Probes; Nanoparticles; Nanotechnology; Neoplasms, Experimental; Optical Imaging; Ovarian Neoplasms; Spectrum Analysis, Raman	2017
High levels of iron supplementation prevents neural tube defects in the Fpn1 Birth defects research, 2017, 01-30, Volume: 109, Issue:2 Topics: Animals; Cation Transport Proteins; Crosses, Genetic; Dietary Supplements; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Folic Acid Deficiency; Gene Deletion; Humans; Iron; Maternal Nutritional Physiological Phenomena; Mice; Mice, Transgenic; Neural Tube; Neural Tube Defects; Penetrance; Pregnancy; Prosencephalon	2017
Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis. American journal of physiology. Renal physiology, 2017, 03-01, Volume: 312, Issue:3 Topics: Animals; Cell Communication; Complement Activation; Complement C1q; Complement C3; Cytokines; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Fibrosis; Folic Acid; Genotype; Inflammation Mediators; Kidney Tubules; Leukocyte Common Antigens; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Pericytes; Phenotype; Receptor, Platelet-Derived Growth Factor beta; Renal Insufficiency, Chronic; Time Factors; Ureteral Obstruction; Wnt Signaling Pathway; Wnt3A Protein	2017
Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017, Volume: 33, Issue:3 Topics: Animals; Animals, Newborn; Apoptosis; Betaine; Blood Alcohol Content; Calpain; Caspase 3; Cathepsin B; Cathepsin L; Central Nervous System Depressants; Cerebral Cortex; Cytochromes c; Disease Models, Animal; Ethanol; Female; Folic Acid; Neuroprotective Agents; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley	2017
Gremlin1 plays a key role in kidney development and renal fibrosis. American journal of physiology. Renal physiology, 2017, 06-01, Volume: 312, Issue:6 Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Fibrosis; Folic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Mice, Inbred C57BL; Mice, Knockout; Organogenesis; Phenotype; Signal Transduction; Time Factors; Urogenital Abnormalities	2017
Role of homocysteine and folic acid on the altered calcium homeostasis of platelets from rats with biliary cirrhosis. Platelets, 2017, Volume: 28, Issue:7 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Bile Ducts; Blood Platelets; Calcium; Calcium Signaling; Cholestasis; Disease Models, Animal; Folic Acid; Homocysteine; Ligation; Liver Cirrhosis, Biliary; Male; Platelet Aggregation; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thrombin	2017
High folic acid diet enhances tumour growth in PyMT-induced breast cancer. British journal of cancer, 2017, Mar-14, Volume: 116, Issue:6 Topics: Animals; Antigens, Polyomavirus Transforming; Diet; Disease Models, Animal; Female; Folate Receptor 1; Folic Acid; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Polyomavirus; STAT3 Transcription Factor	2017
Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity. Seizure, 2017, Volume: 46 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Astrocytes; Cell Count; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Female; Folic Acid; Hippocampus; Homocysteine; Liver; Male; Neurogenesis; Neurons; Organ Size; Rats, Wistar; Valproic Acid	2017
Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model. Pharmaceutical biology, 2017, Volume: 55, Issue:1 Topics: Animals; Cardiotoxicity; Celecoxib; Disease Models, Animal; Folic Acid; Heart Failure; Male; Random Allocation; Rats; Rats, Wistar	2017
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2 Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents	2008
Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:11 Topics: Adult Stem Cells; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cells, Cultured; Cognition Disorders; Cyclin E; Dementia; Dentate Gyrus; Disease Models, Animal; Fibroblast Growth Factor 2; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Hyperhomocysteinemia; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurodegenerative Diseases; Neurons; Trigeminal Caudal Nucleus	2008
Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:1 Topics: Animals; Disease Models, Animal; Extracellular Matrix; Folic Acid; Homocysteine; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Glomerulus; Matrix Metalloproteinases; NADPH Oxidases; Oxidative Stress; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; RNA; Sclerosis; Superoxides; Tissue Inhibitor of Metalloproteinase-1; Transfection	2009
Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer. Epigenetics, 2008, Volume: 3, Issue:6 Topics: Acetylation; Animals; Body Weight; Butyrates; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Diet; Dietary Supplements; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Histones; Mice; Mice, Inbred ICR; Odds Ratio; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Transcription, Genetic	2008
Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake. American journal of obstetrics and gynecology, 2009, Volume: 200, Issue:2 Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Female; Folic Acid; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Pre-Eclampsia; Pregnancy	2009
Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test. Behavioural brain research, 2009, Jun-08, Volume: 200, Issue:1 Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Excitatory Amino Acid Antagonists; Exploratory Behavior; Folic Acid; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Swimming	2009
Addressing a folate imbalance in fetal cerebrospinal fluid can decrease the incidence of congenital hydrocephalus. Journal of neuropathology and experimental neurology, 2009, Volume: 68, Issue:4 Topics: Age Factors; Animals; Bromodeoxyuridine; Cell Movement; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cerebrospinal Fluid; Chi-Square Distribution; Disease Models, Animal; Drug Combinations; Embryo, Mammalian; Female; Folic Acid; Hydrocephalus; Leucovorin; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Stem Cells; Tetrahydrofolates; Vitamin B Complex	2009
MMP9 and SCF protect from apoptosis in acute kidney injury. Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:4 Topics: Acute Disease; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Folic Acid; Kidney; Kidney Tubules; Kidney Tubules, Proximal; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Stem Cell Factor; Wounds and Injuries	2009
Metabolism of methionine in vivo: impact of pregnancy, protein restriction, and fatty liver disease. Nestle Nutrition workshop series. Paediatric programme, 2009, Volume: 63 Topics: Animals; Diet, Protein-Restricted; Disease Models, Animal; Fatty Liver; Female; Fetal Growth Retardation; Folic Acid; Humans; Insulin Resistance; Methionine; Models, Animal; Pregnancy	2009
Folate receptor alpha regulates cell proliferation in mouse gonadotroph alphaT3-1 cells. Experimental cell research, 2009, Nov-01, Volume: 315, Issue:18 Topics: Adenoma; Animals; Carrier Proteins; Cell Line; Cell Proliferation; Disease Models, Animal; Folate Receptors, GPI-Anchored; Folic Acid; Gonadotrophs; Humans; Mice; Pituitary Neoplasms; Proliferating Cell Nuclear Antigen; Receptor, Notch3; Receptors, Cell Surface; Receptors, Notch; Transfection; Up-Regulation	2009
One-carbon metabolism-genome interactions in folate-associated pathologies. The Journal of nutrition, 2009, Volume: 139, Issue:12 Topics: Animals; Carbon; Child; Developmental Disabilities; Disease Models, Animal; Environment; Folic Acid; Gastrointestinal Neoplasms; Genetic Phenomena; Genome, Human; Homocysteine; Humans; Methionine; Mice; Neural Tube Defects; Purines; Risk Factors; Thymidine Monophosphate	2009
Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:3 Topics: Animals; Calcium-Binding Proteins; Cell Line; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Cytokines; Disease Models, Animal; Disease Progression; Female; Fibrosis; Folic Acid; Humans; Kidney Tubules, Distal; Kidney Tubules, Proximal; Mice; Mice, Inbred Strains; Reactive Oxygen Species; Renal Insufficiency; S100 Calcium-Binding Protein A4; S100 Proteins	2010
Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats. Annals of nutrition & metabolism, 2010, Volume: 56, Issue:2 Topics: Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Glutathione; Homocysteine; Male; Methionine; Rats; Rats, Sprague-Dawley; Vitamin B Complex	2010
Folic Acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model. Journal of Alzheimer's disease : JAD, 2010, Volume: 20, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Folic Acid; Gene Expression Profiling; Humans; Maze Learning; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Oligonucleotide Array Sequence Analysis; Peptide Fragments; Reaction Time; Spatial Behavior; Time Factors; Up-Regulation; Vitamin B Complex	2010
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine. Pharmacology, biochemistry, and behavior, 2010, Volume: 95, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Cisterna Magna; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Homocysteine; Inflammation Mediators; Injections, Spinal; Male; Memory Disorders; Methotrexate; Motor Activity; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Long-Evans; Recognition, Psychology; Time Factors	2010
Decreased level of 5-methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis. Journal of the neurological sciences, 2010, Jun-15, Volume: 293, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Mice; Mice, Transgenic; Severity of Illness Index; Statistics as Topic; Superoxide Dismutase; Tandem Mass Spectrometry; Tetrahydrofolates; Time Factors	2010
Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133. Radiology, 2010, Volume: 255, Issue:2 Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Dextrans; Disease Models, Animal; Female; Ferrosoferric Oxide; Folic Acid; Humans; In Vitro Techniques; Magnetic Resonance Imaging; Magnetite Nanoparticles; Nanoparticles; Rats; Rats, Nude; Receptors, Cell Surface; Statistics, Nonparametric; Transplantation, Heterologous	2010
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:1 Topics: Animals; beta Catenin; Chick Embryo; Disease Models, Animal; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Folic Acid; Heart; Heart Defects, Congenital; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Pregnancy; Random Allocation; Ultrasonography, Doppler; Wnt Proteins	2010
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models. The Journal of nutritional biochemistry, 2011, Volume: 22, Issue:3 Topics: Alzheimer Disease; Analysis of Variance; Animals; Carbon; Cell Line; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenomics; Female; Folic Acid; Humans; Male; Methylation; Mice; Mice, 129 Strain; Mice, Transgenic; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency	2011
Folic acid administration prevents ouabain-induced hyperlocomotion and alterations in oxidative stress markers in the rat brain. Bipolar disorders, 2010, Volume: 12, Issue:4 Topics: Animals; Antimanic Agents; Biomarkers; Bipolar Disorder; Disease Models, Animal; Folic Acid; Hippocampus; Injections, Intraventricular; Lithium Chloride; Male; Motor Activity; Ouabain; Oxidative Stress; Rats; Rats, Wistar	2010
Dietary folic acid activates AMPK and improves insulin resistance and hepatic inflammation in dietary rodent models of the metabolic syndrome. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2010, Volume: 42, Issue:11 Topics: AMP-Activated Protein Kinases; Animals; Diet; Dietary Supplements; Disease Models, Animal; Enzyme Activation; Fatty Liver; Folic Acid; Hep G2 Cells; Hepatitis; Humans; Insulin Resistance; Liver; Male; Metabolic Syndrome; Obesity; Rats; Rats, Wistar	2010
The folic acid combined with 17-β estradiol produces antidepressant-like actions in ovariectomized rats forced to swim. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jan-15, Volume: 35, Issue:1 Topics: Analysis of Variance; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estradiol; Exploratory Behavior; Female; Fluoxetine; Folic Acid; Injections, Intraventricular; Ovariectomy; Rats; Rats, Wistar; Stress, Psychological; Swimming	2011
Functional interactions between the LRP6 WNT co-receptor and folate supplementation. Human molecular genetics, 2010, Dec-01, Volume: 19, Issue:23 Topics: Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Gene Expression; Gene Expression Regulation, Developmental; Immunohistochemistry; LDL-Receptor Related Proteins; Low Density Lipoprotein Receptor-Related Protein-6; Methionine; Mice; Mice, Inbred C3H; Mitochondria; Mutation; Neural Crest; Neural Tube Defects; NIH 3T3 Cells; Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Signal Transduction; Wnt Proteins	2010
Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid. Cardiovascular toxicology, 2011, Volume: 11, Issue:1 Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Female; Fluoresceins; Folic Acid; Heart Diseases; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Myocardium; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Reactive Nitrogen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2011
Protective effects of selenium on methimazole-induced anemia and oxidative stress in adult rats and their offspring. Human & experimental toxicology, 2011, Volume: 30, Issue:10 Topics: Anemia; Animals; Animals, Newborn; Animals, Suckling; Antioxidants; Antithyroid Agents; Ascorbic Acid; Disease Models, Animal; Female; Folic Acid; Glutathione; Hematologic Tests; Iron; Lipid Peroxidation; Male; Malondialdehyde; Methimazole; Oxidative Stress; Oxidoreductases; Pregnancy; Pregnancy Complications, Hematologic; Protective Agents; Rats; Rats, Wistar; Selenium; Vitamin B 12; Vitamin E	2011
Folic acid enhances early functional recovery in a piglet model of pediatric head injury. Developmental neuroscience, 2010, Volume: 32, Issue:5-6 Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Cognition Disorders; Disease Models, Animal; Female; Folic Acid; Learning; Male; Neuroprotective Agents; Recovery of Function; Swine; Vitamin B Complex	2010
Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis. Journal of biomedicine & biotechnology, 2011, Volume: 2011 Topics: Analysis of Variance; Animals; Arthritis, Experimental; beta-Galactosidase; Chitosan; Dinoprostone; Disease Models, Animal; DNA; Drug Delivery Systems; Female; Folic Acid; Freund's Adjuvant; Histocytochemistry; Humans; Injections, Intravenous; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Muscle, Skeletal; Nanoconjugates; Nanoparticles; Rats; Rats, Inbred Lew; Tarsus, Animal; Tissue Distribution	2011
Hyperhomocysteinemia decreases bone blood flow. Vascular health and risk management, 2011, Jan-25, Volume: 7 Topics: Animals; Biomarkers; Biomechanical Phenomena; Blood Pressure; Bone Density; Bone Remodeling; Disease Models, Animal; Folic Acid; Homocysteine; Hyperhomocysteinemia; Laser-Doppler Flowmetry; Male; Osteoporosis; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tibia; Time Factors; Up-Regulation; Vitamin B 12	2011
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. The American journal of clinical nutrition, 2011, Volume: 93, Issue:4 Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Gene Expression; Glycine Hydroxymethyltransferase; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Tube Defects; Purines; Severity of Illness Index; Thymidine Monophosphate; Thymidylate Synthase; Vitamin B Complex	2011
A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Blood, 2011, May-05, Volume: 117, Issue:18 Topics: Animals; Base Sequence; Bone Marrow; Disease Models, Animal; DNA Primers; Erythropoiesis; Female; Folic Acid; Folic Acid Deficiency; Gene Targeting; Humans; Intestinal Absorption; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pancytopenia; Proton-Coupled Folate Transporter; Spleen	2011
Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid. Human & experimental toxicology, 2012, Volume: 31, Issue:3 Topics: Animals; Brain; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Therapy, Combination; Folic Acid; Hypothalamus; Hypothyroidism; Male; Norepinephrine; Propylthiouracil; Rats; Serotonin; Thyrotropin; Triiodothyronine; Vitamin B Complex	2012
Fetal neural tube stem cells from Pax3 mutant mice proliferate, differentiate, and form synaptic connections when stimulated with folic acid. Stem cells and development, 2012, Jan-20, Volume: 21, Issue:2 Topics: Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Embryo, Mammalian; Fetal Stem Cells; Fetus; Folic Acid; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Homozygote; Mice; Mice, Knockout; Neural Stem Cells; Neural Tube; Neurons; Paired Box Transcription Factors; PAX3 Transcription Factor; Receptor, Fibroblast Growth Factor, Type 4; Signal Transduction; Spinal Dysraphism; Synapses	2012
Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver. Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:6 Topics: Animals; Betaine; Choline; Dietary Fats; Dietary Sucrose; Dietary Supplements; Disease Models, Animal; Fatty Liver; Folic Acid; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Vitamin B 12	2011
Chemopreventive effect of epigallocatechin-3-gallate (EGCG) and folic acid on the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastrointestinal cancer in rat model. Journal of digestive diseases, 2011, Volume: 12, Issue:3 Topics: Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Apoptosis; Catechin; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Folic Acid; Gastrointestinal Neoplasms; Hematinics; Male; Methylnitronitrosoguanidine; Rats; Rats, Wistar; Sarcoma; Treatment Outcome	2011
Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring. Gut, 2011, Volume: 60, Issue:12 Topics: Animals; Animals, Newborn; Colorectal Neoplasms; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pregnancy; Prenatal Exposure Delayed Effects; Riboflavin; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin D Deficiency; Wnt Signaling Pathway	2011
Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Human molecular genetics, 2011, Sep-15, Volume: 20, Issue:18 Topics: Animals; Dietary Supplements; Disease Models, Animal; Embryonic Development; Female; Folic Acid; Humans; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neural Tube; Neural Tube Defects; Pregnancy; Survival	2011
Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia. Kidney international, 2011, Volume: 80, Issue:6 Topics: Acute Kidney Injury; Animals; Bacterial Load; Blood Platelets; Disease Models, Animal; Folic Acid; Kidney; Lung; Mice; Mice, Inbred C57BL; Models, Biological; Neutrophils; Organ Specificity; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections	2011
Dietary folate deficiency blocks prostate cancer progression in the TRAMP model. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; CpG Islands; Diet; Disease Models, Animal; Disease Progression; DNA Methylation; Folic Acid; Folic Acid Deficiency; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prostate; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; RNA, Messenger	2011
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist. Behavioural brain research, 2011, Dec-01, Volume: 225, Issue:2 Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology	2011
Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. Journal of Alzheimer's disease : JAD, 2011, Volume: 27, Issue:3 Topics: Aging; Animals; Chronic Disease; Dietary Supplements; Disease Models, Animal; Drug Therapy, Combination; Folic Acid; Hyperhomocysteinemia; Male; Memory Disorders; Phosphorylation; Rats; Rats, Sprague-Dawley; tau Proteins; Vitamin B 12	2011
Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Folic Acid; Lactic Acid; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Vitamin B Complex	2011
Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:1 Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Biopterins; Blood Pressure; Disease Models, Animal; Folic Acid; Genetic Therapy; GTP Cyclohydrolase; Hypertension; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Nitric Oxide; Nitric Oxide Synthase Type III; Tetrahydrofolate Dehydrogenase; Vasoconstrictor Agents; Vitamin B Complex	2012
Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction. American journal of physiology. Heart and circulatory physiology, 2012, Feb-01, Volume: 302, Issue:3 Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Biomarkers; Disease Models, Animal; Folic Acid; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Pulmonary Artery; Reactive Oxygen Species; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Ventricular Remodeling; Vitamin B Complex	2012
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. The American journal of clinical nutrition, 2012, Volume: 95, Issue:1 Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Energy Intake; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; Mice; Mice, Knockout; Neural Tube Defects; Risk Factors	2012
Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes. Molecular and cellular biochemistry, 2012, Volume: 363, Issue:1-2 Topics: Administration, Oral; Alcoholism; Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Ethanol; Folic Acid; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Enzymologic; Homeostasis; Intestines; Kidney; Liver; Male; Membrane Transport Proteins; Minor Histocompatibility Antigens; Pancreas; Peptide Synthases; Proton-Coupled Folate Transporter; Rats; Rats, Wistar; Reduced Folate Carrier Protein; RNA, Messenger; Time Factors	2012
[Protective effects and its mechanism on neural cells after folic acid intervention in preeclampsia rat model]. Zhonghua fu chan ke za zhi, 2011, Volume: 46, Issue:8 Topics: Animals; Apoptosis; Disease Models, Animal; Female; Folic Acid; Homocysteine; Male; Neurons; Neuroprotective Agents; NF-kappa B; Pre-Eclampsia; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Sodium Glutamate	2011
Folic acid supplementary reduce the incidence of adenocarcinoma in a mouse model of colorectal cancer: microarray gene expression profile. Journal of experimental & clinical cancer research : CR, 2011, Volume: 30 Topics: Adenocarcinoma; Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Folic Acid; Mice; Mice, Inbred ICR; Random Allocation; Risk Factors; Transcriptome	2011
Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice. Gastroenterology, 2012, Volume: 142, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Disease Models, Animal; DNA Methylation; Folic Acid; Gastric Mucosa; Gastrins; Gastritis; Gene Expression Profiling; Gene Expression Regulation; Helicobacter felis; Helicobacter Infections; Homocysteine; Immunohistochemistry; Lymphocytes; Male; Mice; Mice, Transgenic; Myofibroblasts; Stomach; Stomach Neoplasms; Stromal Cells; Up-Regulation	2012
TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation. Kidney international, 2012, Volume: 81, Issue:11 Topics: Adult; Animals; Antibodies, Neutralizing; Biopsy; Cell Line; Chemokine CXCL16; Chemokine CXCL6; Chemokines, CXC; Chemotaxis; Cytokine TWEAK; Disease Models, Animal; Female; Folic Acid; Gene Expression Profiling; Humans; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nephritis, Interstitial; NF-kappa B; Receptors, Scavenger; Receptors, Tumor Necrosis Factor; Recombinant Proteins; RNA, Messenger; Sesquiterpenes; T-Lymphocytes; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factors; TWEAK Receptor; Up-Regulation	2012
One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:8 Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Blood Urea Nitrogen; Creatinine; Cyclosporine; Cytokine TWEAK; Disease Models, Animal; Fibrosis; Folic Acid; Immunosuppressive Agents; Interleukin-6; Lipocalin-2; Lipocalins; Male; Mice; NF-kappa B; Oncogene Proteins; Tumor Necrosis Factors	2012
Folate supplementation limits the tumourigenesis in rodent models of gliomagenesis. European journal of cancer (Oxford, England : 1990), 2012, Volume: 48, Issue:15 Topics: Animals; Cell Transformation, Neoplastic; Dietary Supplements; Disease Models, Animal; DNA Methylation; Folic Acid; Glioma; Humans; Mice; Survival Analysis; Xenograft Model Antitumor Assays	2012
Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutritional neuroscience, 2012, Volume: 15, Issue:2 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Dietary Supplements; Disease Models, Animal; Folic Acid; Hippocampus; Homeodomain Proteins; Infarction, Middle Cerebral Artery; Male; Neurogenesis; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Repressor Proteins; Signal Transduction; Stroke; Transcription Factor HES-1	2012
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. The American journal of clinical nutrition, 2012, Volume: 95, Issue:4 Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Embryo Loss; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genes, Lethal; Heterozygote; Homocysteine; Hypoxanthine; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Mutant Strains; Multienzyme Complexes; Mutagenesis, Insertional; Neural Tube Defects; Pregnancy	2012
The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney international, 2012, Volume: 82, Issue:2 Topics: Animals; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Connective Tissue Growth Factor; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epithelial Cells; Fibrosis; Folic Acid; Gene Expression Regulation; Heptanoates; Kidney Diseases; Kidney Tubules; Macrophages; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor beta1; Ureteral Obstruction	2012
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine. Behavioural brain research, 2012, Aug-01, Volume: 233, Issue:2 Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Area Under Curve; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Folic Acid; Homocysteine; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Stereotyped Behavior; Vitamin B Complex	2012
Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney international, 2012, Volume: 82, Issue:5 Topics: Acute Kidney Injury; Adherens Junctions; Animals; Apoptosis; bcl-2-Associated X Protein; beta Catenin; Cadherins; Cell Line; Creatinine; Disease Models, Animal; Epithelial Cells; Folic Acid; gamma Catenin; Genotype; Humans; Inhibitor of Apoptosis Proteins; Kidney Tubules; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Repressor Proteins; Survivin; Time Factors; Transfection; Tumor Suppressor Protein p53; Wnt1 Protein	2012
Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats. Diabetes, 2012, Volume: 61, Issue:8 Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Folic Acid; Hyperalgesia; Male; Nerve Fibers; Neural Conduction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyridoxal Phosphate; Rats; Rats, Zucker; Sciatic Nerve; Tibial Nerve; Tyrosine; Vitamin B 12	2012
4-1BB-mediated signals confer protection against folic acid-induced nephrotoxicity. Kidney & blood pressure research, 2012, Volume: 36, Issue:1 Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Fibrosis; Folic Acid; Immune System; Kidney Diseases; Kidney Tubules; Male; Mice; Mice, Inbred Strains; Signal Transduction; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 9	2012
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects. BMC medical genetics, 2012, Aug-02, Volume: 13 Topics: Animals; Case-Control Studies; Disease Models, Animal; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Humans; Ireland; Mice; Neural Tube Defects; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12	2012
Folate-conjugated rapamycin slows progression of polycystic kidney disease. Journal of the American Society of Nephrology : JASN, 2012, Volume: 23, Issue:10 Topics: Animals; Cell Line; Disease Models, Animal; Endocytosis; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Kidney; Mice; Polycystic Kidney, Autosomal Dominant; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2012
Folic acid prevents depressive-like behavior and hippocampal antioxidant imbalance induced by restraint stress in mice. Experimental neurology, 2013, Volume: 240 Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Folic Acid; Hippocampus; Male; Mice; Oxidative Stress; Restraint, Physical; Stress, Psychological	2013
1H NMR-based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl4 administration. Toxicology, 2013, Jan-07, Volume: 303 Topics: Acute Lung Injury; Animals; Carbon Tetrachloride; Disease Models, Animal; Energy Metabolism; Folic Acid; Injections, Intraperitoneal; Lipids; Liver Regeneration; Magnetic Resonance Spectroscopy; Male; Metabolomics; Mice; Multivariate Analysis; Principal Component Analysis; Rats; Rats, Wistar; Time Factors; Vitamin B 12	2013
Targeting folate receptors to treat invasive urinary bladder cancer. Cancer research, 2013, Jan-15, Volume: 73, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Cell Line, Tumor; Disease Models, Animal; Dogs; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Male; Maximum Tolerated Dose; Mice; Mice, Nude; Middle Aged; Pilot Projects; Urinary Bladder Neoplasms; Vinblastine	2013
Intestinal absorption of folic acid - new physiologic & molecular aspects. The Indian journal of medical research, 2012, Volume: 136, Issue:5 Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Male	2012
Mechanism of intestinal folate transport during folate deficiency in rodent model. The Indian journal of medical research, 2012, Volume: 136, Issue:5 Topics: Animals; Base Sequence; Biological Transport; Diet; Disease Models, Animal; DNA Methylation; DNA Primers; Folic Acid; Folic Acid Deficiency; Male; Microvilli; Rats; Rats, Wistar	2012
Protein-resistant, reductively dissociable polyplexes for in vivo systemic delivery and tumor-targeting of siRNA. Biomaterials, 2013, Volume: 34, Issue:9 Topics: Animals; Cell Survival; Dextrans; Disease Models, Animal; Female; Folic Acid; Gene Silencing; Gene Transfer Techniques; HeLa Cells; Humans; KB Cells; Mice; Mice, Nude; Nanoparticles; Neoplasms; Polyethyleneimine; Protein Conformation; RNA, Small Interfering; Transfection	2013
Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice. The Journal of nutrition, 2013, Volume: 143, Issue:3 Topics: Animals; Betaine; Choline; Craniofacial Abnormalities; Dietary Supplements; Disease Models, Animal; Face; Female; Folic Acid; Gastrulation; Jaw; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Parity; Pregnancy; Proteins; Risk Factors; Vitamin B 12; Vitamin B Complex	2013
Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:5 Topics: Animals; Brain; Cerebral Hemorrhage; Dementia, Vascular; Diet; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-1beta; Interleukin-6; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Memory Disorders; Methionine; Mice; Mice, Inbred C57BL; Vitamin B 12; Vitamin B 6	2013
Parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2. Kidney international, 2013, Volume: 83, Issue:5 Topics: Active Transport, Cell Nucleus; Acute Kidney Injury; Animals; Apoptosis; Cell Line; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Epithelial Cells; Folic Acid; Humans; Kidney Failure, Chronic; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Osteopontin; Parathyroid Hormone-Related Protein; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Signal Transduction; Time Factors; Transfection	2013
Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis and rheumatism, 2002, Volume: 46, Issue:7 Topics: Animals; Arthritis, Experimental; Carrier Proteins; Chelating Agents; Disease Models, Animal; Female; Folate Receptors, GPI-Anchored; Folic Acid; Macrophages; Radioligand Assay; Radionuclide Imaging; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Technetium	2002
The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr. Molecular genetics and metabolism, 2002, Volume: 76, Issue:4 Topics: 5' Flanking Region; Animals; Cholates; Disease Models, Animal; Folic Acid; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors	2002
Folic acid and NTD--continued: genetic variants. Teratology, 2002, Volume: 66, Issue:2 Topics: Animals; Disease Models, Animal; Folic Acid; Humans; Mice; Neural Tube Defects	2002
Will caloric restriction and folate protect against AD and PD? Neurology, 2003, Feb-25, Volume: 60, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Brain; Brain-Derived Neurotrophic Factor; Caloric Restriction; Disease Models, Animal; Energy Intake; Folic Acid; Homocysteine; Humans; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Rats; Risk Factors	2003
Amelioration of sodium valproate-induced neural tube defects in mouse fetuses by maternal folic acid supplementation during gestation. Congenital anomalies, 2003, Volume: 43, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Brain; Dietary Supplements; Disease Models, Animal; Enzyme Inhibitors; Female; Folic Acid; Maternal Exposure; Mice; Neural Tube Defects; Time Factors; Valproic Acid; Vitamin B 12	2003
Combination therapy with folic acid and methionine in the prevention of retinoic acid-induced cleft palate in mice. Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid; Injections, Intraperitoneal; Methionine; Mice; Pregnancy; Teratogens; Tretinoin	2003
Intimal hyperplasia following carotid endarterectomy in an insulin-resistant rat model. Metabolism: clinical and experimental, 2003, Volume: 52, Issue:7 Topics: Animals; Cystathionine gamma-Lyase; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Sucrose; Disease Models, Animal; Endarterectomy, Carotid; Folic Acid; Homocysteine; Hyperplasia; Insulin; Insulin Resistance; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley; Tunica Intima	2003
Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation. Journal of the American College of Cardiology, 2003, Jul-16, Volume: 42, Issue:2 Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cyclic GMP; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Folic Acid; Hindlimb; Homocysteine; Hypercholesterolemia; Ischemia; Male; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peripheral Vascular Diseases; Rats; Rats, Sprague-Dawley; Risk Factors; Severity of Illness Index	2003
Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:11 Pt 1 Topics: Animals; beta 2-Microglobulin; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colorectal Neoplasms; Diet; Dietary Supplements; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Humans; Interleukin-2; Mice; Mice, Inbred C57BL	2003
Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E. Neuromolecular medicine, 2003, Volume: 4, Issue:3 Topics: Aging; Animals; Apolipoproteins E; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Maze Learning; Mice; Mice, Knockout; Neurodegenerative Diseases; Oxidative Stress; Vitamin E; Vitamin E Deficiency	2003
Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice. Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carrier Proteins; Diet; Disease Models, Animal; Embryo Loss; Female; Folate Receptors, GPI-Anchored; Folic Acid; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neural Tube Defects; Pregnancy; Receptors, Cell Surface; Valproic Acid	2003
Antibodies to folate receptors impair embryogenesis and fetal development in the rat. Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:10 Topics: Animals; Antibodies, Blocking; Antibody Specificity; Autoantibodies; Carrier Proteins; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Therapy, Combination; Embryonic and Fetal Development; Female; Folate Receptors, GPI-Anchored; Folic Acid; Injections, Intraperitoneal; Leucovorin; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface	2003
Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits. The Journal of nutritional biochemistry, 2004, Volume: 15, Issue:2 Topics: Aging; Animals; Disease Models, Animal; Fatty Acids; Folic Acid; Glutathione; Homocysteine; Lipid Peroxidation; Liver; Metabolic Clearance Rate; Rabbits; Thiobarbituric Acid Reactive Substances	2004
Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. Journal of controlled release : official journal of the Controlled Release Society, 2004, Mar-24, Volume: 95, Issue:3 Topics: Animals; Coated Materials, Biocompatible; Disease Models, Animal; Endocytosis; Female; Folic Acid; Gadolinium; Humans; KB Cells; Mice; Mice, Nude; Nanotechnology; Neoplasms; Particle Size; Polyethylene Glycols; Technology, Pharmaceutical; Tissue Distribution	2004
Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. Pathology, research and practice, 2004, Volume: 200, Issue:1 Topics: Animals; Antineoplastic Agents; Cleft Palate; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fetal Growth Retardation; Folic Acid; Hematinics; Male; Pregnancy; Procarbazine; Rats; Sex Factors	2004
Folic acid supplementation enhances repair of the adult central nervous system. Annals of neurology, 2004, Volume: 56, Issue:2 Topics: Animals; Cell Count; Central Nervous System; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Folic Acid; Ganglia, Spinal; Male; Nerve Regeneration; Neurons; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Spinal Cord Injuries; Statistics, Nonparametric; Time Factors	2004
Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinoma. Cancer letters, 2004, Sep-30, Volume: 213, Issue:2 Topics: Animals; Ascites; Carcinoma; Carrier Proteins; Disease Models, Animal; Drug Delivery Systems; Female; Flow Cytometry; Folate Receptors, GPI-Anchored; Folic Acid; Liposomes; Macrophages; Mice; Ovarian Neoplasms; Receptors, Cell Surface	2004
Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery. Academic radiology, 2004, Volume: 11, Issue:9 Topics: Animals; Carrier Proteins; Coated Materials, Biocompatible; Contrast Media; Dextrans; Disease Models, Animal; Endocytosis; Ferric Compounds; Folate Receptors, GPI-Anchored; Folic Acid; Humans; KB Cells; Lung Neoplasms; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Nanostructures; Nasopharyngeal Neoplasms; Plasma Substitutes; Radiographic Image Enhancement; Receptors, Cell Surface; Sensitivity and Specificity; Tissue Distribution; Tumor Cells, Cultured	2004
Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery. Molecular pharmacology, 2004, Volume: 66, Issue:6 Topics: Animals; Carrier Proteins; Disease Models, Animal; Endocytosis; Folate Receptors, GPI-Anchored; Folic Acid; HeLa Cells; Humans; KB Cells; Leukemia L1210; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentetic Acid; Protein Binding; Receptors, Cell Surface	2004
Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury. Stem cells (Dayton, Ohio), 2005, Volume: 23, Issue:1 Topics: Acute Kidney Injury; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Disease Models, Animal; Female; Folic Acid; Immunohistochemistry; In Situ Hybridization, Fluorescence; In Vitro Techniques; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Species Specificity	2005
Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia. The Journal of nutrition, 2005, Volume: 135, Issue:3 Topics: Animals; Cerebrovascular Circulation; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Energy Intake; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Reference Values; Thiobarbituric Acid Reactive Substances; Vitamin B 12; Weight Gain	2005
Arthritis imaging using a near-infrared fluorescence folate-targeted probe. Arthritis research & therapy, 2005, Volume: 7, Issue:2 Topics: Animals; Arthritis, Experimental; Carrier Proteins; Disease Models, Animal; Early Diagnosis; Feasibility Studies; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Folic Acid; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Protein Isoforms; Receptors, Cell Surface; Spectroscopy, Near-Infrared; Synovial Fluid	2005
What have animal studies told us about the role of folic acid and vitamin B12 in health? Forum of nutrition, 2003, Volume: 56 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Vitamin B 12; Vitamin B 12 Deficiency	2003
Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II. The Journal of nutrition, 2005, Volume: 135, Issue:8 Topics: Animals; Dietary Supplements; Disease Models, Animal; Factor X; Factor XII; Folic Acid; Folic Acid Deficiency; Hyperhomocysteinemia; Male; Prothrombin; Rats; Rats, Inbred WKY	2005
Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract. The Journal of nutrition, 2006, Volume: 136, Issue:3 Suppl Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Garlic; Homocysteine; Hyperhomocysteinemia; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley	2006
Hyperhomocysteinemia increases damage on brain slices exposed to in vitro model of oxygen and glucose deprivation: prevention by folic acid. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2006, Volume: 24, Issue:4 Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Folic Acid; Glucose; Homocysteine; Hyperhomocysteinemia; Hypoxia; Hypoxia-Ischemia, Brain; In Vitro Techniques; Lactate Dehydrogenases; Male; Rats; Rats, Wistar; Vitamin A; Vitamin B Complex	2006
Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis research & therapy, 2006, Volume: 8, Issue:3 Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Immunotherapy; Macrophages; Male; Mice; Mice, Inbred DBA; Rats; Rats, Inbred Lew; Weight-Bearing	2006
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. European journal of nutrition, 2006, Volume: 45, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Homocystine; Mice; Neural Tube Defects; Pregnancy; Random Allocation; Teratogens; Valproic Acid; Vitamin B 12	2006
Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementation. Biochimica et biophysica acta, 2006, Volume: 1762, Issue:7 Topics: Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Immunohistochemistry; Liver; Male; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Superoxides	2006
Recent advances in the prevention of congenital heart disease. Current opinion in pediatrics, 2006, Volume: 18, Issue:5 Topics: Animals; Disease Models, Animal; Folic Acid; Forecasting; Heart Defects, Congenital; Humans; Infant, Newborn; Polymorphism, Genetic; Risk Factors; Vitamin B Complex	2006
Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European journal of pharmacology, 2006, Dec-03, Volume: 551, Issue:1-3 Topics: Animals; Clotrimazole; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mesenteric Arteries; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Vasodilation; Vasodilator Agents	2006
The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects. The Journal of comparative neurology, 2007, Jan-10, Volume: 500, Issue:2 Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Cell Differentiation; Cell Proliferation; Central Nervous System; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Humans; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Neural Tube Defects; Neuroglia; Neurons; Paired Box Transcription Factors; PAX3 Transcription Factor; Retinal Dehydrogenase; Stem Cells; Up-Regulation	2007
Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat. American journal of hypertension, 2007, Volume: 20, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Antihypertensive Agents; Biopterins; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; F2-Isoprostanes; Folic Acid; Glucocorticoids; Homocysteine; Hypertension; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thymus Gland; Time Factors	2007
[Benefits of TS-1 plus leucovorin combination therapy for colorectal cancer: evaluation of therapeutic effect of TS-1 and leucovorin combination therapy using rodent model fed a low folate diet]. Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diet; Disease Models, Animal; Drug Combinations; Drug Evaluation; Folic Acid; Humans; Leucovorin; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Oxonic Acid; Tegafur	2007
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Molecular genetics and metabolism, 2007, Volume: 91, Issue:1 Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine	2007
The use of an in vivo model to study the effects of hyperhomocysteinaemia on vascular function. The Journal of surgical research, 2008, Volume: 145, Issue:1 Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Folic Acid; Hyperhomocysteinemia; Male; Methionine; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	2008
[Effects of folic acid, vitamin B(6) and vitamin B(12) on learning and memory function in cerebral ischemia rats]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2007, Volume: 41, Issue:3 Topics: Animals; Brain Ischemia; Disease Models, Animal; Female; Folic Acid; Homocysteine; Infarction, Middle Cerebral Artery; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Vitamin B 12; Vitamin B 6; Vitamin B Complex	2007
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:11 Topics: Animals; Body Weight; Disease Models, Animal; Ethanol; Fatty Liver; Female; Folic Acid; Folic Acid Deficiency; Linear Models; Liver; Liver Diseases, Alcoholic; Male; Methionine; Necrosis; Oxidative Stress; S-Adenosylmethionine; Swine; Swine, Miniature	2007
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:5 Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Cell Membrane; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kinetics; Male; Membrane Potentials; Membrane Transport Proteins; Methotrexate; Mice; Mice, Inbred C57BL; Microvilli; Molecular Sequence Data; Oocytes; Polyglutamic Acid; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Proton-Coupled Folate Transporter; Rats; RNA, Messenger; Tetrahydrofolates; Xenopus	2007
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4]. Georgian medical news, 2007, Issue:150 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochromes b5; Disease Models, Animal; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hepatocytes; Homocysteine; Male; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6; Vitamin B Complex	2007
Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. The FEBS journal, 2007, Volume: 274, Issue:24 Topics: Alcoholism; Animals; Biological Transport; Blotting, Western; Cell Membrane; Disease Models, Animal; DNA Methylation; Down-Regulation; Erythrocytes; Ethanol; Folic Acid; Gene Expression; Immunohistochemistry; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Kinetics; Membrane Transport Proteins; Microscopy, Electron, Transmission; Microvilli; Rats; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium	2007
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency. Journal of inherited metabolic disease, 2008, Volume: 31, Issue:3 Topics: Animals; Brain; Disease Models, Animal; Female; Folic Acid; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Survival Rate; Tetrahydrofolates	2008
Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. Neuropharmacology, 2008, Volume: 54, Issue:7 Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Inflammation; Mice; Mice, Transgenic; Motor Neurons; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rotarod Performance Test; Spinal Cord; Superoxide Dismutase; Vitamin B 12; Vitamin B Complex	2008
Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney international, 2008, Volume: 74, Issue:3 Topics: Adenoviridae; Angiopoietin-1; Animals; Disease Models, Animal; Fibrosis; Folic Acid; Genetic Vectors; Inflammation; Kidney Diseases; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Renal Circulation	2008
The homocysteine paradox. Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6 Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6	2008
Methyl group deficiency in nerve tissue: a hypothesis to explain the lesion of subacute combined degeneration. Irish journal of medical science, 1980, Volume: 149, Issue:1 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cercopithecus; Disease Models, Animal; Folic Acid; Haplorhini; Macaca fascicularis; Methylation; Methyltransferases; Nerve Tissue; Nitrous Oxide; Peripheral Nervous System Diseases; Spinal Cord Diseases; Vitamin B 12 Deficiency	1980
An essay on research into the causation and prevention of spina bifida. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1981, Volume: 34, Issue:4 Topics: Animals; Ascorbic Acid; Disease Models, Animal; Female; Folic Acid; Genotype; Gestational Age; Humans; Mice; Mice, Neurologic Mutants; Neural Tube Defects; Pregnancy; Sex Factors; Spina Bifida Occulta; Vitamin A	1981
The induction of functional vitamin B-12 deficiency in rats by exposure to nitrous oxide. Biochimica et biophysica acta, 1980, Mar-20, Volume: 628, Issue:3 Topics: Animals; Bone Marrow; Deoxyuridine; Disease Models, Animal; DNA; Female; Folic Acid; Formyltetrahydrofolates; Nitrous Oxide; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency	1980
Pharmacokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys. Toxicology and applied pharmacology, 1994, Volume: 128, Issue:2 Topics: Administration, Inhalation; Animals; Carbon Dioxide; Chromatography, Gas; Disease Models, Animal; Environmental Exposure; Female; Folic Acid; Folic Acid Deficiency; Formates; Isotope Labeling; Macaca fascicularis; Methanol; Respiration; Respiratory Function Tests; Spectrum Analysis	1994
Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data. Journal of toxicology and environmental health, 1994, Volume: 41, Issue:1 Topics: Administration, Inhalation; Administration, Oral; Aerosols; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Formates; Liver; Macaca mulatta; Male; Methanol; Rats	1994
Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. The American journal of pathology, 1996, Volume: 149, Issue:4 Topics: Animals; Colon; Colorectal Neoplasms; Disease Models, Animal; DNA Methylation; Exons; Folic Acid; Genes, p53; Male; Monomethylhydrazine; Precancerous Conditions; Rats; Rats, Sprague-Dawley	1996
How does folic acid prevent neural tube defects? Nature medicine, 1998, Volume: 4, Issue:8 Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Animals; Disease Models, Animal; Embryonic and Fetal Development; Female; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases; Pregnancy; Spinal Dysraphism	1998
Modulation of fluorouracil antitumor activity by folic acid in a murine model system. Biochemical pharmacology, 1999, Sep-01, Volume: 58, Issue:5 Topics: Animals; Antidotes; Antimetabolites, Antineoplastic; Diet; Disease Models, Animal; Drug Synergism; Fluorouracil; Folic Acid; Folic Acid Deficiency; Leucovorin; Mice; Mice, Inbred C3H; Neoplasms, Experimental	1999
Crooked tail (Cd) models human folate-responsive neural tube defects. Human molecular genetics, 1999, Volume: 8, Issue:12 Topics: Animals; Disease Models, Animal; Female; Folic Acid; Humans; Mice; Mice, Inbred CBA; Mice, Mutant Strains; Neural Tube Defects	1999
The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. Carcinogenesis, 1999, Volume: 20, Issue:12 Topics: Animals; Base Sequence; Carcinogens; Colorectal Neoplasms; Dimethylhydrazines; Disease Models, Animal; DNA Primers; Folic Acid; Genes, APC; Genes, p53; Male; Mutation; Rats; Rats, Inbred F344; Rats, Sprague-Dawley	1999
Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats. Plant foods for human nutrition (Dordrecht, Netherlands), 1999, Volume: 54, Issue:4 Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Calcium, Dietary; Carcinogens; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Disease Models, Animal; Folic Acid; Male; Random Allocation; Rats; Rats, Inbred F344	1999
Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:3 Topics: Animals; Aorta; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Folic Acid; Food, Formulated; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Thrombomodulin; Vasodilator Agents	2000
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6 Topics: Adaptation, Physiological; Amino Acid Sequence; Animals; Body Weight; Carrier Proteins; Disease Models, Animal; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; gamma-Glutamyl Hydrolase; Gene Expression; Intestinal Absorption; Intestinal Mucosa; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; RNA, Messenger; Transcription, Genetic; Tritium	2000
Genetic basis of susceptibility to environmentally induced neural tube defects. Annals of the New York Academy of Sciences, 2000, Volume: 919 Topics: Animals; Carrier Proteins; Cell Cycle; Disease Models, Animal; DNA Fingerprinting; Embryonic and Fetal Development; Environmental Pollutants; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Predisposition to Disease; Gestational Age; Growth Substances; Humans; Hyperthermia, Induced; Mice; Mice, Knockout; Neural Tube Defects; Polymorphism, Single-Stranded Conformational; Receptors, Cell Surface; Valproic Acid	2000
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status. Journal of gastroenterology and hepatology, 2000, Volume: 15, Issue:10 Topics: Animals; Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Data Interpretation, Statistical; Disease Models, Animal; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Injections, Subcutaneous; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Risk Factors; Time Factors	2000
Vitamin B-12 deficiency and hyperhomocysteinemia are partly ameliorated by cobalt and nickel supplementation in pigs. The Journal of nutrition, 2000, Volume: 130, Issue:12 Topics: Animal Feed; Animals; Cobalt; Copper; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Iron; Liver; Male; Nickel; Swine; Trace Elements; Vitamin B 12; Vitamin B 12 Deficiency	2000
Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys. Circulation, 2001, Feb-20, Volume: 103, Issue:7 Topics: Animals; Arteriosclerosis; Blood Coagulation; Carotid Arteries; Cholesterol; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Folic Acid; Hypercholesterolemia; Hyperhomocysteinemia; In Vitro Techniques; Macaca fascicularis; Partial Thromboplastin Time; Pyridoxine; Thrombin; Treatment Outcome; Vascular Diseases; Vasodilation; Vasodilator Agents; Vitamin B 12	2001
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. The Journal of clinical investigation, 2001, Volume: 107, Issue:6 Topics: Animals; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Diet; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridoxine; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thromboplastin; Vascular Cell Adhesion Molecule-1; Vasculitis; Vitamin B 12	2001
Genetic aspects of nutrition and toxicology: report of a workshop. Journal of the American College of Nutrition, 2001, Volume: 20, Issue:2 Suppl Topics: Aging; Animals; Diet; Dietary Fats, Unsaturated; Disease Models, Animal; Folic Acid; Gene Expression Regulation; Humans; Neoplasms; Nutritional Physiological Phenomena; Toxicology; Zinc	2001
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circulation research, 2001, Jun-08, Volume: 88, Issue:11 Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System	2001
Folic-acid-mediated inhibition of human colon-cancer cell growth. Nutrition (Burbank, Los Angeles County, Calif.), 2001, Volume: 17, Issue:9 Topics: Adenocarcinoma; Animals; Caco-2 Cells; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; DNA Methylation; Folic Acid; Humans; Tetrahydrofolates	2001
Folate homeostasis and antiproliferative activity of folates and antifolates. Nutrition (Burbank, Los Angeles County, Calif.), 2001, Volume: 17, Issue:9 Topics: Animals; Caco-2 Cells; Cell Division; Colonic Neoplasms; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homeostasis; Homocysteine; Humans; Kinetics; Mice; Risk Factors	2001
Up-regulation of parathyroid hormone-related protein in folic acid-induced acute renal failure. Kidney international, 2001, Volume: 60, Issue:3 Topics: Acute Kidney Injury; Angiotensin II; Animals; Cell Division; Disease Models, Animal; Endothelin-1; Endothelins; Epithelial Cells; Folic Acid; Immunohistochemistry; Kidney Cortex; Kidney Tubules; Male; Parathyroid Hormone-Related Protein; Peptidyl-Dipeptidase A; Protein Precursors; Proteins; Rats; Rats, Wistar; Regeneration; Up-Regulation	2001
Folate supplementation inhibits intimal hyperplasia induced by a high-homocysteine diet in a rat carotid endarterectomy model. Journal of vascular surgery, 2001, Volume: 34, Issue:3 Topics: Animals; Dietary Supplements; Disease Models, Animal; Endarterectomy, Carotid; Folic Acid; Homocysteine; Hyperplasia; Rats; Rats, Sprague-Dawley; Tunica Intima	2001
Effects of preparation and cooking of folic acid-fortified foods on the availability of folic acid in a folate depletion/repletion rat model. Journal of agricultural and food chemistry, 2001, Volume: 49, Issue:9 Topics: Animals; Biological Availability; Cooking; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Food Handling; Food, Fortified; Male; Rats; Rats, Wistar	2001
Folic acid prevents exencephaly in Cited2 deficient mice. Human molecular genetics, 2002, Feb-01, Volume: 11, Issue:3 Topics: Animals; Apoptosis; Disease Models, Animal; DNA-Binding Proteins; Ectoderm; Fetal Death; Folic Acid; Genetic Vectors; Genotype; Mesoderm; Mice; Mice, Inbred C57BL; Morphogenesis; Mutation; Neural Tube Defects; Repressor Proteins; Trans-Activators	2002
Folic acid supplementation on red kidney bean-induced diarrhoea and enteric bacterial translocation into mesenteric lymph nodes in rats: a pilot study. Acta paediatrica (Oslo, Norway : 1992), 2002, Volume: 91, Issue:1 Topics: Animals; Bacterial Physiological Phenomena; Bacterial Translocation; Colony Count, Microbial; Diarrhea; Diet; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Gastric Mucosa; Intestinal Mucosa; Lymph Nodes; Male; Mesentery; Pilot Projects; Probability; Rats; Rats, Inbred LEC; Reference Values; Sensitivity and Specificity	2002
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology, 2002, Volume: 65, Issue:5 Topics: Animals; Body Weight; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Male; Mice; Mice, Inbred ICR; Neural Tube Defects; Pregnancy	2002
Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mammalian genome : official journal of the International Mammalian Genome Society, 2002, Volume: 13, Issue:5 Topics: Animals; Blotting, Northern; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Liver; Methylmalonic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Oligonucleotide Array Sequence Analysis; Signal Transduction	2002
Strategy for the treatment of acute myelogenous leukemia based on folate receptor beta-targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid. Blood, 2002, Jul-15, Volume: 100, Issue:2 Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carrier Proteins; Cell Death; Disease Models, Animal; Doxorubicin; Drug Delivery Systems; Drug Evaluation, Preclinical; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; Leukemia, Myeloid, Acute; Liposomes; Mice; Receptors, Cell Surface; Survival Rate; Therapeutic Equivalency; Treatment Outcome; Tretinoin; Tumor Cells, Cultured	2002
Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. Investigative urology, 1976, Volume: 13, Issue:4 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Body Weight; Disease Models, Animal; DNA; Folic Acid; Hydrogen-Ion Concentration; Kidney; Kidney Tubular Necrosis, Acute; Male; Mice; Organ Size; Polyribosomes; Proteins; RNA; Solubility	1976
Folacin deficiency and requirement in the squirrel monkey (Saimiri sciuresus). The American journal of clinical nutrition, 1979, Volume: 32, Issue:12 Topics: Animals; Blood Cells; Body Weight; Bone Marrow Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Folic Acid; Folic Acid Deficiency; Haplorhini; Hematologic Tests; Hemoglobins; Nutritional Requirements; Saimiri	1979
Alcohol interference with the folate enterohepatic cycle. Transactions of the Association of American Physicians, 1977, Volume: 90 Topics: Alcoholism; Animals; Bile; Disease Models, Animal; Enterohepatic Circulation; Female; Folic Acid; Folic Acid Deficiency; Humans; Liver; Methylation; Oxidation-Reduction; Rats	1977
A survey of the effect of some drugs, chemicals, and enzymes on calcium oxalate precipitation in the rat kidney. Investigative urology, 1978, Volume: 15, Issue:6 Topics: Animals; Calcium; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Folic Acid; Hydrochlorothiazide; Methylene Blue; Muramidase; Neuraminidase; Oxalates; Phosphates; Rats; Trypan Blue; Urinary Calculi; Vitamin A	1978
Lack of effect of norethindrone and mestranol on folacin depletion and repletion in rats. The Journal of nutrition, 1977, Volume: 107, Issue:7 Topics: Animals; Body Weight; Contraceptives, Oral, Combined; Disease Models, Animal; Drug Implants; Drug Synergism; Female; Folic Acid; Folic Acid Deficiency; Glutamates; Kidney; Liver; Mestranol; Norethindrone; Organ Size; Rats	1977
Reduction of folic acid-induced acute tubular injury by diuresis: an experimental model. Experimental and molecular pathology, 1976, Volume: 25, Issue:1 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Body Weight; Disease Models, Animal; Diuresis; DNA; Folic Acid; Furosemide; Kidney; Kidney Tubular Necrosis, Acute; Male; Mice; Organ Size; RNA	1976
Malnutrition, the thymolymphatic system and immunocompetence. Advances in experimental medicine and biology, 1976, Volume: 73 Pt B Topics: Adolescent; Adult; Anemia, Megaloblastic; Animals; Antibody Formation; Child; Disease Models, Animal; DNA Replication; Folic Acid; Folic Acid Deficiency; Humans; Iron; Lectins; Lymphocytes; Middle Aged; Nutrition Disorders; Rats; Spleen; Thymus Gland; Transferrin; Vitamin B 12	1976
The effect of diet and alcohol on the development of folate deficiency in the rat. British journal of haematology, 1975, Volume: 31, Issue:2 Topics: Animals; Diet; Disease Models, Animal; Ethanol; Female; Folic Acid; Folic Acid Deficiency; Kidney; Liver; Rats	1975
Aging, chronic administration of ethanol, and acute exposure to nitrous oxide: effects on vitamin B12 and folate status in rats. Mechanisms of ageing and development, 1992, Mar-01, Volume: 62, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Alcoholism; Animals; Disease Models, Animal; Folic Acid; Male; Nitrous Oxide; Rats; Rats, Inbred F344; Vitamin B 12	1992
[Treatment of pneumocystosis: preclinical evaluation]. Revue de pneumologie clinique, 1991, Volume: 47, Issue:3 Topics: Animals; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Folic Acid; Humans; Pneumocystis; Pneumonia, Pneumocystis; Rats; Rats, Inbred Strains; Trimethoprim, Sulfamethoxazole Drug Combination	1991
Effects of chronic ethanol and diet treatment on urinary folate excretion and development of folate deficiency in the rat. The Journal of nutrition, 1989, Volume: 119, Issue:10 Topics: Alcoholism; Animals; Diet; Disease Models, Animal; Ethanol; Folic Acid; Folic Acid Deficiency; Homeostasis; Male; Rats; Rats, Inbred Strains; Sulfonamides	1989
Folate absorption in alcoholic pigs: in vivo intestinal perfusion studies. The American journal of clinical nutrition, 1989, Volume: 50, Issue:6 Topics: Alanine Transaminase; Alcoholism; Animals; Aspartate Aminotransferases; Disease Models, Animal; Female; Folic Acid; Hydrolysis; Intestinal Absorption; Jejunum; Liver; Male; Perfusion; Pteroylpolyglutamic Acids; Succinate Dehydrogenase; Swine; Swine, Miniature	1989
Folate absorption in alcoholic pigs: in vitro hydrolysis and transport at the intestinal brush border membrane. The American journal of clinical nutrition, 1989, Volume: 50, Issue:6 Topics: Alcoholism; Animals; Biological Transport; Disease Models, Animal; Fluorescence Polarization; Folic Acid; gamma-Glutamyl Hydrolase; Hydrolysis; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Membrane Fluidity; Microvilli; Pteroylpolyglutamic Acids; Swine; Swine, Miniature	1989
Nutritional folate deficiency in Chinese hamster ovary cells. I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors. Journal of cellular physiology, 1989, Volume: 140, Issue:2 Topics: Animals; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cricetinae; Disease Models, Animal; Female; Flow Cytometry; Folic Acid; Folic Acid Deficiency; Hypoxanthines; Nucleic Acid Precursors; Ovary; Phenotype; Thymidine	1989
Experimental folic acid nephropathy. Pathology, 1987, Volume: 19, Issue:2 Topics: Ammonium Chloride; Animals; Bicarbonates; Disease Models, Animal; Female; Folic Acid; Kidney; Kidney Diseases; Rats; Sodium; Sodium Bicarbonate	1987
Inciting excitotoxic cytocide among central neurons. Advances in experimental medicine and biology, 1986, Volume: 203 Topics: Action Potentials; Animals; Brain; Cell Survival; Chick Embryo; Cholinergic Fibers; Disease Models, Animal; Edema; Epilepsies, Partial; Folic Acid; Hippocampus; Hypoxia; Kainic Acid; Ketamine; Microscopy, Electron; Parasympathomimetics; Phencyclidine; Piperidines; Seizures; Synaptic Transmission; Thalamus	1986
Heat- and alcohol-induced neural tube defects: interactions with folate in a golden hamster model. Pediatric research, 1985, Volume: 19, Issue:2 Topics: Animals; Cricetinae; Disease Models, Animal; Ethanol; Female; Folic Acid; Hot Temperature; Mesocricetus; Neural Tube Defects; Pregnancy	1985
Nutritional vitamin B12 deficiency in rhesus monkeys. The American journal of clinical nutrition, 1974, Volume: 27, Issue:5 Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Bone Marrow Cells; Demyelinating Diseases; Disease Models, Animal; Erythrocyte Count; Erythrocytes; Folic Acid; Haplorhini; Hematocrit; Hemoglobins; Leukocyte Count; Liver; Macaca; Male; Malonates; Nervous System; Spinal Cord Diseases; Vitamin B 12; Vitamin B 12 Deficiency	1974
The experimental production of vitamin B12 deficiency in the baboon (Papio cynocephalus). A 2-year study. The British journal of nutrition, 1974, Volume: 32, Issue:2 Topics: Ampicillin; Animals; Azo Compounds; Biopsy; Blood Cell Count; Body Weight; Disease Models, Animal; FIGLU Test; Folic Acid; Glutarates; Growth; Haplorhini; Hematocrit; Hepatectomy; Histidine; Liver; Male; Malonates; Papio; Propionates; Sodium; Valine; Vitamin B 12; Vitamin B 12 Deficiency	1974
A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:4 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Brain Neoplasms; Disease Models, Animal; Drug Evaluation, Preclinical; Ependymoma; Folic Acid; Male; Mice; Mice, Inbred C57BL; Mutation; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nitrosourea Compounds; Purines; Steroids; Time Factors	1974
Folate metabolism and the anticonvulsant efficacy of phenobarbital. Archives of neurology, 1973, Volume: 28, Issue:1 Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital; Rats; Seizures; Vitamin B 12	1973
The effect of a milk diet on Babesia microti and B. hylomysci infections in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1973, Volume: 67, Issue:1 Topics: Aminobenzoates; Animals; Babesiosis; Diet; Disease Models, Animal; Folic Acid; Mice; Milk; Quinolizines	1973
Acute renal failure in the rat after folate intoxication: diagnostic value of lactate dehydrogenase and alkaline phosphatase measurements in serum and urine. Clinical nephrology, 1974, Volume: 2, Issue:3 Topics: Acute Kidney Injury; Alkaline Phosphatase; Animals; Bicarbonates; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Folic Acid; Hydrogen-Ion Concentration; Isoenzymes; L-Lactate Dehydrogenase; Male; Rats	1974
Fatal Shigella infection induced by folic acid deficiency in young guinea pigs. The Journal of infectious diseases, 1970, Volume: 121, Issue:3 Topics: Animals; Animals, Newborn; Bone Marrow; Diet; Disease Models, Animal; Dysentery, Bacillary; Feces; Folic Acid; Folic Acid Deficiency; Growth; Guinea Pigs; Hemagglutination Tests; Shigella	1970
Haematological study of a rodent malaria model. The Journal of tropical medicine and hygiene, 1970, Volume: 73, Issue:1 Topics: Anemia; Animals; Anopheles; Blood; Blood Cell Count; Blood Platelets; Bone Marrow Cells; Disease Models, Animal; Erythrocytes, Abnormal; Folic Acid; Hemoglobins; Iron; Leukocyte Count; Liver; Malaria; Mice; Monocytes; Organ Size; Spleen; Splenectomy	1970