folic acid has been researched along with Depressive Disorder, Major in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (42.00) | 29.6817 |
| 2010's | 21 (42.00) | 24.3611 |
| 2020's | 8 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doery, JC; Galletly, C; Griffin, RC; Lam, NSK; Li, X; Lim, F; Long, XX; Saad, M | 1 |
| Brent, DA; Finegold, DN; Hughes, M; Hyland, K; Naviaux, RK; Pan, LA; Peters, DG; Segreti, AM; Shaw, A; Vockley, J; Wrobleski, J | 1 |
| Ekinci, GN; Sanlier, N | 1 |
| Amini, M; Hosseinzadeh, M; Khosravi, M; Mansoori, A; Raisi, F; Sotoudeh, G | 1 |
| Huang, X; Li, W; Lu, XB; Ning, YP; Qi, H; Sim, K; Ungvari, GS; Xiang, YT; Xiao, L; Zheng, W | 1 |
| Alexander, R; Carboni, L; Delafont, B; Domenici, E; Ivanchenko, E; Learned, SM; Ratti, E | 1 |
| Stengler, M | 1 |
| Altaf, R; Gonzalez, I; Nemec, EC; Rubino, K | 1 |
| Carter, B; Roberts, E; Young, AH | 1 |
| Caneo, C; Trincado, J | 1 |
| Bleich, S; Frieling, H; Helm, S; Hillemacher, T; Jakubovski, E; Kahl, KG; Maier, H; Moschny, N; Neyazi, A; Sperling, W; Toto, S | 1 |
| Taylor, MJ | 1 |
| Kumar, CN; Pandey, RS; Venkatasubramanian, R | 1 |
| Owen, RT | 1 |
| Delport, D; Fisher, LR; Geiger, D; Kotze, MJ; Schoeman, R; van der Merwe, L; van der Merwe, N | 1 |
| Brutsche, NE; Ionescu, DF; Luckenbaugh, DA; Lundin, NB; Machado-Vieira, R; Niciu, MJ; Richards, EM; Vande Voort, JL; Zarate, CA | 1 |
| Cowen, PJ; Geddes, JR; Hockney, R; McPeake, L; Sharpley, AL | 1 |
| De Long, NE; Hardy, DB; Holloway, AC; Hyslop, JR; Raha, S | 1 |
| Assies, J; Bockting, CL; de Vries, GJ; Derks, EM; Kayser, M; Koeter, MW; Lok, A; Mocking, RJ; Schene, AH; Visser, I | 1 |
| Almeida, OP; Flicker, L; Ford, AH; Hirani, V; McCaul, K; Singh, V; vanBockxmeer, FM | 1 |
| Ahmad, J; Kar, SK; Singh, J | 1 |
| Assies, J; Bockting, CL; Koeter, MW; Lok, A; Mocking, RJ; Pouwer, F; Ruhé, HG; Schene, AH; Visser, I | 1 |
| Hastings, CN; Mondelli, V; Pariante, CM; Sheridan, H | 1 |
| Apitz, R; Campos, J; García, A; Lavie, R; Lima, L; Mata, S; Resler, G; Urbina, M | 1 |
| Heok, KE; Ho, R | 1 |
| Farah, A | 1 |
| Shelton, RC | 1 |
| Frankenburg, FR | 1 |
| Fava, M; Mischoulon, D | 2 |
| Stahl, SM | 2 |
| Nahas, R; Sheikh, O | 1 |
| Fava, M; Shelton, RC; Zajecka, JM | 1 |
| Berk, M; Jacka, FN; Maes, M; Pasco, JA; Williams, LJ | 1 |
| Alpert, JE; Baer, L; Clain, AJ; Dording, CM; Farabaugh, AH; Fava, M; Iosifescu, DV; Katz, J; Lamon-Fava, S; Mischoulon, D; Nierenberg, AA; Papakostas, GI; Selhub, J; Yeung, AS | 1 |
| Budni, J; dos Santos, AA; Engel, D; Farina, M; Moretti, M; Ornell, F; Quevedo, J; Rodrigues, AL; Santos, DB; Valvassori, SS; Zomkowski, AD | 1 |
| Alpert, M; Pouget, ER; Silva, RR | 1 |
| Bolander-Gouaille, C; Coppen, A | 1 |
| Christensen, H; Jorm, AF; Lux, O; Naidoo, D; Parslow, RA; Sachdev, PS; Salonikas, C; Wen, W | 1 |
| Alpert, JE; Bottiglieri, T; Fava, M; Lebowitz, BD; Mischoulon, D; Nierenberg, AA; Papakostas, GI; Petersen, T; Rosenbaum, JF; Ryan, JL | 1 |
| Alpert, JE; Fava, M; Iosifescu, DV; Lee, HK; Lyoo, IK; Nierenberg, AA; Papakostas, GI; Renshaw, PF | 1 |
| Alpert, JE; Fava, M; Iosifescu, DV; Lee, HK; Lyoo, IK; Nierenberg, A; Papakostas, GI; Renshaw, PF | 1 |
| Alpert, J; Bottiglieri, T; Fava, M; Fraguas, R; Mischoulon, D; Papakostas, GI | 1 |
| Breteler, MM; Fekkes, D; Hofman, A; Kiliaan, AJ; Tiemeier, H; van Tuijl, HR | 1 |
| Fava, M | 1 |
| Mischoulon, D; Raab, MF | 1 |
| Morris, DW; Rush, AJ; Trivedi, MH | 1 |
| Bailey, J; Coppen, A | 1 |
| Gottfries, CG | 1 |
17 review(s) available for folic acid and Depressive Disorder, Major
| Article | Year |
|---|---|
The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review.
Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Disorder; Depressive Disorder, Major; Female; Folic Acid; Humans | 2022 |
The relationship between nutrition and depression in the life process: A mini-review.
Topics: Depression; Depressive Disorder, Major; Diet; Fatty Acids, Omega-3; Folic Acid; Humans; Magnesium; Selenium; Vitamin B 12; Vitamins; Zinc | 2023 |
Adjunctive folate for major mental disorders: A systematic review.
Topics: Antipsychotic Agents; Bipolar Disorder; Depressive Disorder, Major; Folic Acid; Humans; Schizophrenia | 2020 |
Folate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis.
Topics: Depressive Disorder, Major; Folic Acid; Humans; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors | 2021 |
Caveat emptor: Folate in unipolar depressive illness, a systematic review and meta-analysis.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Folic Acid; Humans; Randomized Controlled Trials as Topic | 2018 |
Is augmentation with folate effective for major depressive disorder?
Topics: Antidepressive Agents; Databases, Factual; Depressive Disorder, Major; Dietary Supplements; Folic Acid; Humans; Randomized Controlled Trials as Topic; Treatment Outcome | 2018 |
Folate augmentation of antidepressant response.
Topics: Antidepressive Agents; Depressive Disorder, Major; Drug Therapy, Combination; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Tetrahydrofolates; Treatment Outcome | 2013 |
Does Diet Matter? The Use of Polyunsaturated Fatty Acids (PUFAs) and Other Dietary Supplements in Inflammation-Associated Depression.
Topics: Animals; Depressive Disorder, Major; Dietary Supplements; Fatty Acids, Unsaturated; Folic Acid; Humans; Inflammation; Probiotics; Vitamin B Complex | 2017 |
The many faces of geriatric depression.
Topics: Aged; Brain; Depressive Disorder, Major; Early Diagnosis; Folic Acid; Geriatric Psychiatry; Humans; Hyperhomocysteinemia; Pain; Prevalence; Primary Health Care; Risk Factors; Suicide; Vitamin B 12 Deficiency | 2008 |
The role of L-methylfolate in depressive disorders.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Middle Aged; Vitamin B Complex | 2009 |
Folate in depression: efficacy, safety, differences in formulations, and clinical issues.
Topics: Aged; Chemistry, Pharmaceutical; Clinical Trials as Topic; Dementia; Depressive Disorder, Major; Dietary Supplements; Dosage Forms; Female; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Male; Tetrahydrofolates; Treatment Outcome | 2009 |
Combining antidepressant therapies from the initiation of treatment: a paradigm shift for major depression.
Topics: Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Humans; Hypnotics and Sedatives; Secondary Prevention; Tetrahydrofolates; Treatment Outcome | 2009 |
Complementary and alternative medicine for the treatment of major depressive disorder.
Topics: Acupuncture Therapy; Complementary Therapies; Depressive Disorder, Major; Dietary Supplements; Exercise Therapy; Fatty Acids, Omega-3; Folic Acid; Humans; Hypericum; Phytotherapy; S-Adenosylmethionine | 2011 |
Treatment of depression: time to consider folic acid and vitamin B12.
Topics: Brain; Depressive Disorder, Major; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
The role of folate in depression and dementia.
Topics: Aged; Brain; Dementia; Depressive Disorder, Major; Folic Acid; Folic Acid Deficiency; Humans | 2007 |
Novel therapeutics for depression: L-methylfolate as a trimonoamine modulator and antidepressant-augmenting agent.
Topics: Antidepressive Agents; Depressive Disorder, Major; Dopamine; Drug Synergism; Folic Acid; Humans; Norepinephrine; Serotonin | 2007 |
Folate and unipolar depression.
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Drug Therapy, Combination; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Treatment Outcome | 2008 |
9 trial(s) available for folic acid and Depressive Disorder, Major
| Article | Year |
|---|---|
Folate metabolism biomarkers from two randomised placebo-controlled clinical studies with paroxetine and venlafaxine.
Topics: Biomarkers; Depressive Disorder, Major; Folic Acid; Humans; Paroxetine; Venlafaxine Hydrochloride | 2021 |
A randomized double-blind comparison of fluoxetine augmentation by high and low dosage folic acid in patients with depressive episodes.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Humans; Outpatients; Psychiatric Status Rating Scales; Treatment Outcome; Vitamin B Complex | 2013 |
Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial.
Topics: Bipolar Disorder; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Incidence; Male; Risk | 2014 |
The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
Topics: Adult; Antidepressive Agents; Carbon; Case-Control Studies; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Recurrence; Vitamin B 12; Vitamin B 6 | 2014 |
B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial.
Topics: Aged; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Drug Monitoring; Drug Synergism; Female; Folic Acid; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Remission Induction; Secondary Prevention; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamins | 2014 |
Effect of folic acid combined with fluoxetine in patients with major depression on plasma homocysteine and vitamin B12, and serotonin levels in lymphocytes.
Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Lymphocytes; Male; Middle Aged; Neuropsychological Tests; Selective Serotonin Reuptake Inhibitors; Serotonin; Severity of Illness Index; Treatment Outcome; Vitamin B 12; Vitamin B Complex; Young Adult | 2008 |
Prediction of treatment response in geriatric depression from baseline folate level: interaction with an SSRI or a tricyclic antidepressant.
Topics: Aged; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Female; Folic Acid; Humans; Male; Predictive Value of Tests; Psychiatric Status Rating Scales; Regression Analysis; Selective Serotonin Reuptake Inhibitors; Single-Blind Method; Treatment Outcome | 2003 |
The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Vitamin B 12 | 2005 |
Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Sex Factors; Treatment Outcome; Vitamin B 12 | 2000 |
24 other study(ies) available for folic acid and Depressive Disorder, Major
| Article | Year |
|---|---|
Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior.
Topics: Adolescent; Adult; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Folic Acid; Humans; Metabolomics; Suicidal Ideation | 2023 |
The relationship between dietary patterns and depression mediated by serum levels of Folate and vitamin B12.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Iran; Logistic Models; Male; Middle Aged; Tryptophan; Vitamin B 12; Young Adult | 2020 |
The Role of Folate and MTHFR Polymorphisms in the Treatment of Depression.
Topics: Depression; Depressive Disorder, Major; Folic Acid; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Polymorphism, Genetic | 2021 |
S100B, Homocysteine, Vitamin B12, Folic Acid, and Procalcitonin Serum Levels in Remitters to Electroconvulsive Therapy: A Pilot Study.
Topics: Adult; Aged; Biomarkers; Calcitonin; Depressive Disorder, Major; Electroconvulsive Therapy; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pilot Projects; Remission Induction; S100 Calcium Binding Protein beta Subunit; Severity of Illness Index; Treatment Outcome; Vitamin B 12 | 2018 |
Language bias and comprehensive meta-analysis of folate for unipolar depression.
Topics: Depressive Disorder, Major; Folic Acid; Humans; Language | 2018 |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
Topics: Adult; Biomarkers; Depressive Disorder, Major; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; South Africa; Surveys and Questionnaires | 2014 |
Baseline vitamin B12 and folate levels do not predict improvement in depression after a single infusion of ketamine.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Bipolar Disorder; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Female; Folic Acid; Humans; Ketamine; Male; Middle Aged; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Treatment Outcome; Vitamin B 12 | 2014 |
Fluoxetine-induced pancreatic beta cell dysfunction: New insight into the benefits of folic acid in the treatment of depression.
Topics: Animals; Cell Line; Depressive Disorder, Major; Female; Fluoxetine; Folic Acid; Humans; Insulin-Secreting Cells; Male; Rats; Reactive Oxygen Species; Selective Serotonin Reuptake Inhibitors | 2014 |
Olfactory and gustatory dysfunction in depression: Could it be a marker of folate deficiency?
Topics: Antidepressive Agents; Depressive Disorder, Major; Folic Acid; Folic Acid Deficiency; Humans; Male; Middle Aged; Olfaction Disorders; Taste Disorders; Treatment Outcome; Vitamin B Complex | 2016 |
Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease.
Topics: Adult; Cardiovascular Diseases; Comorbidity; Depressive Disorder, Major; Erythrocytes; Fatty Acids; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Oxidative Stress; Recurrence; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2015 |
The role of L-methylfolate in depressive disorders: commentary.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder, Major; Drug Therapy, Combination; Folic Acid; Humans; Neurotransmitter Agents; Vitamin B Complex | 2009 |
Folate supplementation: is it safe and effective?
Topics: Adolescent; Child; Cross-Sectional Studies; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Humans; Interviews as Topic; Prevalence; Stress Disorders, Post-Traumatic; Surveys and Questionnaires | 2009 |
Evidence for folate in combination with antidepressants at initiation of therapy.
Topics: Adjuvants, Pharmaceutic; Antidepressive Agents; Depressive Disorder, Major; Drug Therapy, Combination; Folic Acid; Humans; Neurotransmitter Agents; Secondary Prevention | 2010 |
Evidence for the use of l-methylfolate combined with antidepressants in MDD.
Topics: Antidepressive Agents; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Folic Acid; Humans; Multicenter Studies as Topic; Patient Selection; Randomized Controlled Trials as Topic | 2011 |
Nutrient intakes and the common mental disorders in women.
Topics: Adult; Aged; Aged, 80 and over; Anxiety Disorders; Depressive Disorder, Major; Diet; Diet Records; Female; Folic Acid; Humans; Magnesium; Micronutrients; Middle Aged; Nutritional Status; Young Adult; Zinc | 2012 |
Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Prevalence; Psychiatric Status Rating Scales; Statistics, Nonparametric; Vitamin B 12; Young Adult | 2012 |
Folic acid prevents depressive-like behavior and hippocampal antioxidant imbalance induced by restraint stress in mice.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Folic Acid; Hippocampus; Male; Mice; Oxidative Stress; Restraint, Physical; Stress, Psychological | 2013 |
Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample.
Topics: Aged; Antioxidants; Australia; Brain; Case-Control Studies; Causality; Creatinine; Cross-Sectional Studies; Depressive Disorder; Depressive Disorder, Major; Female; Folic Acid; Folic Acid Deficiency; Health Status Indicators; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Personality Assessment; Predictive Value of Tests; Psychometrics; Reference Values; Statistics as Topic; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part II).
Topics: Adolescent; Adult; Aged; Ambulatory Care; Brain; Demography; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Vitamin B 12 | 2005 |
Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part I).
Topics: Adolescent; Adult; Aged; Brain; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Severity of Illness Index; Vitamin B 12 | 2005 |
Anger attacks in major depressive disorder and serum levels of homocysteine.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Anger; Creatinine; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index; Smoking; Surveys and Questionnaires; Time Factors; Vitamin B 12 | 2006 |
Plasma pterins and folate in late life depression: the Rotterdam Study.
Topics: Age of Onset; Aged; Aged, 80 and over; Biopterins; Demography; Depressive Disorder, Major; Female; Folic Acid; Humans; Male; Middle Aged; Population Surveillance; Severity of Illness Index; Surveys and Questionnaires | 2006 |
Augmenting antidepressants with folate: a clinical perspective.
Topics: Antidepressive Agents; Depressive Disorder, Major; Drug Synergism; Drug Therapy, Combination; Folic Acid; Humans; Remission Induction | 2007 |
Late life depression.
Topics: Age of Onset; Aged; Brain; Depressive Disorder, Major; Folic Acid; Humans; Prevalence; Vitamin B 12 | 2001 |