folic acid has been researched along with Colonic Neoplasms in 203 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (8.37) | 18.7374 |
| 1990's | 38 (18.72) | 18.2507 |
| 2000's | 73 (35.96) | 29.6817 |
| 2010's | 51 (25.12) | 24.3611 |
| 2020's | 24 (11.82) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, X; Chen, L; Lin, Y; Liu, Z; Luo, Z; Yang, R; Zhang, Z; Zhong, Z; Zhou, M | 1 |
| Abirami, P; Alharthi, SS; Govindarasu, M; Rajakumar, G; Thiruvengadam, M; Vaiyapuri, M | 1 |
| Deng, W; Li, Y; Liu, D; Pan, H; Pan, W; Su, Y; Wang, J | 1 |
| Homayouni Tabrizi, M; Karimi, E; Rahmati, A; Zarei, B | 1 |
| Chanda, N; Halder, S; Jaiswal, N; Mahata, N | 1 |
| Chang, HJ; Kim, J; Lee, J; Oh, JH; Shin, A; Sohn, DK | 1 |
| Chang, H; Deng, Z; Fu, H; He, J; Li, C | 1 |
| Anbalagan, M; Gor, R; Kesavan, Y; Lazer, LM; Narayan, S; Pathak, S; Ramachandran, I; Ramalingam, S | 1 |
| Chen, HH; Chiu, HC; Liu, TI; Lo, CL; Lu, IL; Wang, CY; Yang, YC; Yu, TW | 1 |
| Ali, A; Basit, A; Jan, N; Khan, MM; Khan, S; Madni, A; Rai, N; Shafiq, A; Shah, H | 1 |
| Ardakani, MT; Baneshi, M; Bardania, H; Barmak, MJ; Jafari, F; Mahmoudi, R; Safari, F | 1 |
| David, AE; Sultana, N | 1 |
| Bhaskar, KV; Bhaskaran, NA; Birangal, SR; Gourishetti, K; Hari, G; Jitta, SR; Kulkarni, OP; Kumar, L; Sharma, P; Verma, R | 1 |
| Amaladas, N; Brahmachary, M; Capen, A; Carpenito, C; Chin, D; Chodavarapu, K; Doman, TN; Donoho, GP; Dorsey, FC; Geeganage, S; Hall, GE; Huang, X; Jones, BD; Kalos, M; Li, Y; Lu, ZH; Luo, S; Manro, JR; Meyer, CM; Nikolayev, A; Novosiadly, RD; Rasmussen, ER; Roth, KD; Schaer, DA; Sonyi, A; Surguladze, D; Tan, B | 1 |
| Bestwick, CS; Catala, GN; Duthie, SJ; Giovannelli, L; Lendoiro, E; Moyer, MP; Russell, WR; Tortora, K | 1 |
| Abaci, S; Akbal, O; Bolat, G; Yaman, YT | 1 |
| Ansari, L; Bagheri, E; Derakhshi, M; Malaekeh-Nikouei, B; Shahtahmassebi, N | 1 |
| Dusane, AC; Indukuri, VV; Janardhanam, LSL; Venuganti, VVK; Verma, P | 1 |
| Jiang, Z; Liu, J; Shu, M; Su, M; Xie, J; Zeng, Q | 1 |
| Choi, PS; Kim, GG; Kim, SW; Lee, JY; Park, JH | 1 |
| Borah, PK; Das, AS; Duary, RK; Mukhopadhyay, R; Sarkar, A | 1 |
| Arbely, E; Chen, X; Du, P; Huang, Z; Liu, CY; Qi, Q; Wan, X; Wang, C; Xiang, S; Yu, W; Zhou, D | 1 |
| Cambria, MT; Condorelli, GG; Federico, C; Laudani, S; Pulvirenti, L; Saccone, S; Sinatra, F; Villaggio, G | 1 |
| Álvarez, MA; Álvarez-González, B; Fernández-Perales, M; Rozalen, M; Sánchez-Polo, M | 1 |
| Mason, JB | 2 |
| Faninam, F; Hashemi, M; Kazemi, NM; Khaleghi, S; Mokri, N; Sepehri, Z | 1 |
| Du, YF; Huang, J; Huang, WQ; Luo, WP; Mo, XF; Xu, M; Yan, B; Zhang, CX | 1 |
| Ehlers, A; Lampen, A; Mai, HD; Nemitz, A; Niemann, B; Steinberg, P; Werner, J | 1 |
| Chen, W; Guan, YQ; Han, K; Hu, K; Jin, Y; Li, CH; Meng, Z; Wu, BY; Yin, L; You, R; Zhang, Y | 1 |
| Chen, L; Lu, GR; Pan, CC; Wang, FY; Wang, JZ; Xu, CL; Xue, ZX; Yang, SX; Zheng, B | 1 |
| Boucheix, C; Dairou, J; Desterke, C; Gaston-Mathé, Y; Goldschmidt, E; Haghighi-Rad, F; Machover, D; Mollicone, R; Saffroy, R | 1 |
| Chen, W; Clement, S; Deng, W; Engel, A; Goldys, EM; Guller, A; Zhao, Z | 1 |
| Ghahremani, F; Kefayat, A; Mehrgardi, MA; Motaghi, H; Rostami, S | 1 |
| Al-Attabi, Z; Al-Malky, RN; Al-Maskari, SNM; Al-Ruqaishi, BRS; Ali, A; Deth, RC; Dong, J; Guizani, N; Padmanabhan, S; Rahman, MS; Taranikanti, V; Waly, MI | 1 |
| Jain, A; Jain, AK; Prajapati, SK; Shrivastava, C | 1 |
| Cassata, G; Cavallaro, G; Cicero, L; Giammona, G; Licciardi, M; Puleio, R; Scialabba, C | 1 |
| Chen, HH; Chiang, WH; Chiu, HC; Kv, R; Lin, SC; Liu, TI; Shen, MY; Tsai, YC; Yu, TW | 1 |
| Jain, A; Jain, R; Jain, S; Khatik, R; Veer Kohli, D | 1 |
| Banoth, GS; Dwivedi, AK; Dwivedi, P; Malik, R; Mishra, PR; Pandey, N; Sarkar, J; Sharma, M; Verma, A | 1 |
| Alibrandi, A; Arnaldi, G; Buda, C; Cannavo, S; Cucinotta, D; De Menis, E; Giandalia, A; Ragonese, M; Romanello, G; Romeo, EL; Russo, GT; Torre, ML; Trimarchi, F | 1 |
| Lundgreen, A; Slattery, ML; Wolff, RK | 1 |
| Cho, RC; Cole, PD; Croxford, R; Ishiguro, L; Kamen, BA; Kim, SE; Kim, YI; Ly, A; Sohn, KJ | 1 |
| Chen, L; Gao, W; Kong, LX; Li, P; Wang, Y; Zeng, F | 1 |
| MacFarlane, AJ; McEntee, MF; Stover, PJ | 1 |
| Kong, L; Li, P; Li, S; Peng, Z; Wang, Q; Wang, Y; Yang, Z | 1 |
| Awuah, SG; Bio, M; Nkepang, G; Rajaputra, P; You, Y | 1 |
| Bunout, D; de la Maza, MP; Hirsch, S; Miranda, D; Rodriguez, JM; Ronco, AM | 1 |
| Butler, S; Coomber, BL; Delaney, L; Farias, N; Ho, N; Morrison, J; Shahrzad, S | 1 |
| Cui, Z; Evers, BM; Guo, P; Li, H; Luo, W; Pi, F; Rychahou, PG; Shu, D | 1 |
| He, ZY; Liang, X; Liu, L; Liu, T; Luo, M; Luo, ST; Ma, CC; Ren, J; Song, XR; Wang, BL; Wei, XW; Wei, YQ; Yang, YH | 1 |
| Costache, M; Galateanu, B; Ginghina, O; Hayes, AW; Hudita, A; Ion, RM; Negrei, C; Nikitovic, D; Spandidos, DA; Stan, M; Tsatsakis, AM | 1 |
| Downes, CS; McGlynn, AP; McKerr, G; McNulty, H; Molloy, AM; O'Reilly, SL; Reynolds, J; Scott, JM; Strain, JJ; Ward, M; Wasson, GR; Weir, DG | 1 |
| Croxford, R; Grin, A; Ishiguro, L; Kim, YI; Sohn, KJ; Streutker, CJ; Yang, M | 1 |
| Chen, L; Ducker, GS; Esposito, M; Ghergurovich, JM; Kang, Y; Morscher, RJ; Rabinowitz, JD; Teng, X | 1 |
| Arias, JL; Delgado, ÁV; El-Hammadi, MM; Melguizo, C; Prados, JC | 1 |
| Khalilova, S; Rzayev, ZM; Salimi, K | 1 |
| Ehlers, A; Hirsch-Ernst, KI; Lampen, A; Niemann, B; Weißenborn, A | 1 |
| Bentley, TG; Kuntz, KM; Weinstein, MC; Willett, WC | 1 |
| Fuchs, CS; Ogino, S; Schernhammer, ES | 1 |
| MacFarlane, AJ; Stover, PJ | 1 |
| Waldman, AS; Wyatt, MD; Yang, Z | 1 |
| Cabezas-Herrera, J; García-Cánovas, F; Navarro-Perán, E; Rodríguez-López, JN; Sánchez-Del-Campo, L | 1 |
| Fuchs, CS; Giovannuccci, E; Ogino, S; Schernhammer, ES | 1 |
| Callaway, ES; Chapkin, RS; Davidson, LA; Finnell, RH; George, NI; Kamen, BA; Lupton, JR; Wang, N | 1 |
| Austin, RC; Campan, M; Chiang, EP; Cho, RC; Choi, SW; Dickhout, J; Jang, H; Kim, YI; Laird, PW; Lucock, M; Sohn, KJ; Wang, YC; Weisenberger, DJ; Yates, Z | 1 |
| Albala, C; Barrera, G; Bunout, D; de la Maza, MP; Hirsch, S; Leiva, L; Sanchez, H | 1 |
| Connelly-Frost, A; Kupper, LL; Millikan, RC; Poole, C; Sandler, RS; Satia, JA | 1 |
| El-Lateef, BM; Gomaa, NF; Ismail, HM; Omar, RM; Sheta, M; Yousef, MI | 1 |
| Ahn, YO; Kang, SH; Kim, DH; Kim, J; Lee, BH; Lee, HJ; Lim, SY; Suh, YK | 1 |
| Aufreiter, S; Fukuwatari, T; Mawhinney, T; O'Connor, D; O'Keefe, SJ; Ou, J; Sepulveda, J; Sharma, S; Shibata, K | 1 |
| Butler, LM; Galanko, J; Keku, T; Massa, B; Millikan, RC; Sandler, RS; Steck, SE | 1 |
| Chaudhary, A; Kanthamneni, N; Prabhu, S; Wang, J | 1 |
| Bower, C; Milne, E | 1 |
| Duthie, SJ | 2 |
| Colditz, GA; Freudenheim, JL; Giovannucci, E; Goldbohm, RA; Graham, S; Harnack, L; Hunter, DJ; Jacobs, EJ; Kim, DH; Leitzmann, M; Mannisto, S; Miller, AB; Potter, JD; Rohan, TE; Schatzkin, A; Smith-Warner, SA; Speizer, FE; Spiegelman, D; Stevens, VL; Stolzenberg-Solomon, R; Terry, P; Toniolo, P; Weijenberg, MP; Willett, WC; Wolk, A; Yaun, SS; Zeleniuch-Jacquotte, A | 1 |
| Albanes, D; Bergkvist, L; Buring, JE; Freudenheim, JL; Giovannucci, E; Goldbohm, RA; Harnack, L; Hunter, DJ; Kato, I; Krogh, V; Leitzmann, MF; Limburg, PJ; Marshall, JR; McCullough, ML; Miller, AB; Park, Y; Rohan, TE; Schatzkin, A; Shore, R; Sieri, S; Smith-Warner, SA; Spiegelman, D; Stampfer, MJ; Virtamo, J; Weijenberg, M; Willett, WC; Wolk, A; Zhang, SM | 1 |
| Aumüller, E; Berner, C; Gnauck, A; Haslberger, AG; Just, A; Nestelberger, M | 1 |
| Harada, K; Hiraoka, S; Kaji, E; Kato, J; Kuwaki, K; Matsushima, H; Morikawa, T; Saito, S; Tatsukawa, M; Yamamoto, K | 1 |
| Božo, L; Brčić-Kostić, K; Catela Ivković, T; Gamulin, M; Jokić, M; Kapitanović, S; Stefulj, J | 1 |
| Baba, Y; Fuchs, CS; Giovannucci, E; Ogino, S; Schernhammer, ES | 1 |
| Al-Numair, KS; Ali, A; Alsaif, MA; Essa, MM; Farhat, MF; Waly, MI | 1 |
| Chaudhary, A; Huang, Y; Prabhu, S; Sutaria, D; Wang, J | 1 |
| Gao, Y; Guo, H; Ji, J; Sun, M; Yang, C; Yu, A; Zhai, G; Zhang, L; Zhu, W | 1 |
| Khare, S; Verma, M | 1 |
| Caan, BJ; Curtin, K; Liu, AY; Makar, K; Poole, E; Potter, JD; Scherer, D; Slattery, ML; Ulrich, CM | 1 |
| Behan, NA; Brooks, SP; Caldwell, D; Green, J; MacFarlane, AJ; Matias, FM | 1 |
| Sadik, NA; Shaker, OG | 1 |
| Bogazzi, F; Lombardi, M; Marciano, E; Martino, E; Pellegrini, G; Ruocco, L; Sardella, C; Scattina, I; Signori, S; Urbani, C | 1 |
| Arima, H; Higashi, T; Motoyama, K; Okamatsu, A; Onodera, R | 1 |
| Oakley, GP | 1 |
| Hamilton, P; Khosraviani, K; Moorehead, J; Weir, HP; Williamson, K | 1 |
| Brants, HA; Goldbohm, RA; Konings, EJ; Saris, WH; van den Brandt, PA | 1 |
| Franceschi, S; La Vecchia, C; Negri, E; Pelucchi, C | 1 |
| Keach, J; Kremers, WK; Lindor, KD; Loftus, EV; Pardi, DS | 1 |
| Fallon, UB | 1 |
| König, HH; Leidl, R; Link, KH; Monz, BU; Staib, L | 1 |
| Lamprecht, SA; Lipkin, M | 2 |
| ARDEMAN, S; CHANARIN, I; DOYLE, JC | 1 |
| Kim, YI | 1 |
| Bailey, LB | 1 |
| Curley, SA; Ellis, LM; Gentner, B; Parikh, AA; Vauthey, JN; Wu, TT | 1 |
| Brandenburg, S; Cruz-Correa, M; Cui, H; Feinberg, AP; Giardiello, FM; He, X; Hutcheon, DF; Hylind, L; Kafonek, DR; Powe, NR; Robinson, A; Wu, Y | 1 |
| Jaszewski, R; Kucuk, O; Majumdar, AP; Nagothu, KK; Rishi, AK | 1 |
| Akoglu, B; Caspary, WF; Faust, D; Milovic, V | 1 |
| Ferguson, LR; Karunasinghe, N; Philpott, M | 1 |
| Medinger, M; Mross, K; Steinbild, S | 1 |
| Brink, M; de Bruïne, AP; de Goeij, AF; Goldbohm, RA; Lentjes, MH; Roemen, GM; van den Brandt, PA; van Engeland, M; Weijenberg, MP | 1 |
| Chen, K; Jiang, Q; Li, Q; Ma, X; Shu, G; Yao, K; Yu, W | 1 |
| Allen, JW; DeAngelo, AB; George, MH; Geter, DR; Kilburn, SR; Moore, TM; Nelson, GM; Winkfield, E | 1 |
| Fukushima, M; Hoogeland, MF; Peters, GJ; Temmink, OH | 1 |
| Carethers, JM; Eaton, AM; Galanko, J; Keku, TO; Millikan, RC; Sandler, R | 1 |
| Bigler, J; Caan, B; Curtin, K; Potter, JD; Slattery, ML; Ulrich, CM | 1 |
| Attias, Z; Vaisman, N; Werner, H | 1 |
| Mulder, CJ; Terhaar Sive Droste, JS; Tuynman, JB; Van Dullemen, HM | 1 |
| Iani, V; Juzeniene, A; Ma, L; Moan, J; Steindal, AE | 1 |
| de Bruïne, AP; de Goeij, AF; de Vogel, S; Goldbohm, RA; Lentjes, MH; Lüchtenborg, M; Roemen, GM; van den Brandt, PA; van Engeland, M; Weijenberg, MP | 1 |
| Baykus, H; Dommels, Y; Kampman, E; Keijer, J; Kok, F; Lips, E; Pellis, L; Polanen, Av; Venema, D | 1 |
| Brower, V | 1 |
| Benjamin, MB; Hynes, JB; McCue, GH; Yang, YC | 1 |
| Houghton, JA; Houghton, PJ; Schmidt, C | 1 |
| Okabe, H; Takeda, S; Toko, T; Unemi, N; Yuasa, C | 1 |
| Ascherio, A; Colditz, GA; Giovannucci, E; Rimm, EB; Stampfer, MJ; Willett, WC | 1 |
| Alabaster, O; Frost, A; Shivapurkar, N; Tang, Z | 1 |
| Grygiel, JJ; Mainwaring, P | 1 |
| Allegra, CJ | 1 |
| Bzorek, M; Hansen, SI; Holm, J; Høier-Madsen, M; Søndergaard, K | 1 |
| Ellis, JA; Jackman, MR; Luzio, JP; Shurety, W | 1 |
| Mezger, J | 1 |
| Duch, DS; Dykstra, M; Jansen, M; Knick, VC; Lee, JI; Mullin, RJ; Smith, GK; Stables, J; Topley, P | 1 |
| Lashner, BA | 1 |
| Kim, Y; Mason, JB | 1 |
| Potter, JD | 1 |
| Allegra, CJ; Drake, J; Geoffrey, F; Grem, JL; Johnston, PG; Voeller, D | 1 |
| Choi, SW; Dallal, GE; Graeme-Cook, F; Kim, YI; Mason, JB; Salomon, RN; Smith, DE | 1 |
| Meenan, J; O'Hallinan, E; Scott, J; Weir, DG | 1 |
| Iigo, M; Moriyama, M; Suzuki, I; Tsuda, H | 1 |
| Edwards, SL; Ma, KN; Potter, JD; Schaffer, D; Slattery, ML | 1 |
| Patterson, RE; Shannon, JS; White, E | 1 |
| Boone, WT | 1 |
| Colditz, GA; Fuchs, C; Giovannucci, E; Hunter, DJ; Rosner, BA; Speizer, FE; Stampfer, MJ; Willett, WC | 1 |
| Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK | 1 |
| Grimm, IS; Robertson, DJ | 1 |
| Leppert, M; Potter, JD; Samowitz, W; Schaffer, D; Slattery, ML | 1 |
| Adamek, HE; Riemann, JF | 1 |
| Csiba, A; Hullán, L; Szarvas, T; Szende, B; Trézl, L | 1 |
| Williams, CN | 1 |
| Choi, SW; Mason, JB | 1 |
| Homann, N; Salaspuro, M; Tillonen, J | 1 |
| Brown, SE; Gelroth, JA; Glaser, BK; Ranhotra, GS; Schoening, P | 1 |
| Rothberg, PG | 1 |
| Brand, GM; Duthie, SJ; Grant, G; Narayanan, S | 1 |
| Backus, HH; Jansen, G; Molders, N; Padrón, JM; Peters, GJ; Pinedo, HM; van Der Wilt, CL; van Groeningen, CJ; Wouters, D | 1 |
| Law, M | 1 |
| Gallinger, S; Kim, YI; Mason, JB; Medline, A; Song, J | 1 |
| Le Leu, RK; McIntosh, GH; Young, GP | 2 |
| Little, J | 1 |
| Anderson, K; Curtin, K; Edwards, S; Leppert, M; Ma, KN; Potter, J; Samowitz, WS; Schaffer, D; Slattery, ML | 1 |
| Arab, L; Su, LJ | 1 |
| Willett, WC | 1 |
| Benson, A; Mulcahy, M | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Hoffbrand, AV; Weir, DG | 1 |
| Fawaz, K; Kim, YI; Knox, T; Lee, YM; Libby, E; Mason, JB; Norton, R | 1 |
| Jansen, G; Peters, GJ | 1 |
| Choi, SW; Friso, S | 1 |
| Fan, K; Kopelovich, L; Lipkin, M; Liu, Y; Newmark, HL; Shinozaki, H; Yang, K | 1 |
| Hawk, ET; Umar, A; Viner, JL | 1 |
| Akhurst, T; Balatoni, J; Banerjee, D; Bertino, JR; Blasberg, R; Bornmann, W; Doubrovin, M; Finn, R; Fong, Y; Gelovani Tjuvajev, J; Iwamoto, M; Larson, S; Malhotra, S; Mayer-Kuckuk, P | 1 |
| Colditz, GA; Fuchs, CS; Giovannucci, EL; Hunter, DJ; Speizer, FE; Stampfer, MJ; Willett, WC | 1 |
| Fischman, J | 1 |
| Benito, E; Bosch, FX; Kaldor, J; Mulet, M; Muñoz, N; Obrador, A; Stiggelbout, A | 1 |
| Allegra, CJ; Boarman, D; Chu, E; Zinn, S | 1 |
| Dolnick, BJ; Houghton, JA; Houghton, PJ; Rahman, A; Will, CL | 1 |
| Goméz, G | 1 |
| Adkins, DA; Houghton, JA; Houghton, PJ; Rahman, A | 1 |
| Cholewinski, S; Freudenheim, JL; Graham, S; Haughey, BP; Marshall, JR; Wilkinson, G | 1 |
| Czajkowski, CA; Matherly, LH; Muench, SP; Psiakis, JT | 1 |
| Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF | 1 |
| Hanauer, SB; Heidenreich, PA; Kane, SV; Lashner, BA; Su, GL | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Mason, JB; Rosenberg, IH | 1 |
| Houghton, JA; Houghton, PJ; Radparvar, S | 2 |
| Cantwell, BM; Harris, AL | 1 |
| Duch, DS; Keith, BR; Mullin, RJ | 1 |
| deGraaf, SS; Houghton, JA; Houghton, PJ; Radparvar, S; Rodman, JR; Wainer, IW; Williams, LG | 1 |
| Cantwell, BM; Harding, MJ; Harris, AL; Kaye, SB; Milstead, RA | 1 |
| Adelstein, DJ; Blum, MR; Giroski, P; Hines, JD; Rustum, YM; Zakem, MH | 1 |
| Asbury, RF; Bennett, J; Boros, L; Brower, M; Chang, A; Woll, J | 1 |
| Russell, RM; Sasak, V; Vincent, ML | 1 |
| Leeming, RJ; Melikian, V; Paton, A; Portman-Graham, H | 1 |
25 review(s) available for folic acid and Colonic Neoplasms
| Article | Year |
|---|---|
Folate intake and risk of colorectal cancer: a systematic review and up-to-date meta-analysis of prospective studies.
Topics: Colonic Neoplasms; Colorectal Neoplasms; Diet; Folic Acid; Humans; Prospective Studies; Risk; Risk Factors | 2023 |
Folate, genomic stability and colon cancer: The use of single cell gel electrophoresis in assessing the impact of folate in vitro, in vivo and in human biomonitoring.
Topics: Biological Monitoring; Cell Line; Colonic Neoplasms; Comet Assay; DNA Breaks; DNA Methylation; DNA Repair; DNA Replication; Folic Acid; Folic Acid Deficiency; Genomic Instability; Genotype; Homocystinuria; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Psychotic Disorders; Risk; Single-Cell Analysis; Uracil | 2019 |
[A two-faced vitamin : Folic acid - prevention or promotion of colon cancer?]
Topics: Colonic Neoplasms; Dietary Supplements; Evidence-Based Medicine; Folic Acid; Humans; Plant Extracts; Risk Assessment; Treatment Outcome | 2017 |
Mouse models to elucidate mechanisms of folate-related cancer pathologies.
Topics: Animals; Cell Nucleus; Colonic Neoplasms; Disease Models, Animal; Folic Acid; Gene Expression; Glycine Hydroxymethyltransferase; Humans; Mice; Nutritional Physiological Phenomena | 2008 |
Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis.
Topics: Animals; Carcinoma; Colonic Neoplasms; DNA Damage; DNA Methylation; DNA Repair; Epistasis, Genetic; Folic Acid; Folic Acid Deficiency; Humans; Models, Biological; Neoplasms | 2011 |
Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer.
Topics: Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Confidence Intervals; Diet; Female; Folic Acid; Humans; Incidence; Male; Proportional Hazards Models; Prospective Studies; Risk | 2010 |
Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies.
Topics: Ascorbic Acid; Case-Control Studies; Cohort Studies; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Europe; Female; Folic Acid; Follow-Up Studies; Humans; Incidence; Male; Multivariate Analysis; North America; Proportional Hazards Models; Prospective Studies; Randomized Controlled Trials as Topic; Reproducibility of Results; Risk Assessment; Vitamin A; Vitamin E; Vitamins | 2010 |
Epigenetics of colon cancer.
Topics: Adenocarcinoma; Colonic Neoplasms; CpG Islands; DNA Methylation; Epigenesis, Genetic; Folic Acid; Histones; Humans; MicroRNAs; Risk Factors | 2012 |
Inertia on folic acid fortification: public health malpractice.
Topics: Chile; Colonic Neoplasms; Congenital Abnormalities; Controlled Clinical Trials as Topic; Folic Acid; Food, Fortified; Myocardial Infarction; Netherlands; Public Health; Randomized Controlled Trials as Topic; Stroke; United Kingdom; United States; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms.
Topics: Animals; Anticarcinogenic Agents; Calcium, Dietary; Colonic Neoplasms; Folic Acid; Gene Expression Regulation; Humans; Mice; Models, Biological; Signal Transduction; Vitamin D | 2003 |
Mouse models of gastrointestinal tumorigenesis for dietary cancer prevention studies.
Topics: Adenomatous Polyposis Coli; Animals; Colonic Neoplasms; Diet; Folic Acid; Mice; Models, Biological | 2003 |
Role of folate in colon cancer development and progression.
Topics: Anticarcinogenic Agents; Colonic Neoplasms; Diet; Folic Acid; Health Promotion; Humans; Nutritional Physiological Phenomena | 2003 |
Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations.
Topics: Adenoma; Alcohol Drinking; Colonic Neoplasms; Folic Acid; Humans; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Neoplasms; Nutrition Policy; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12 | 2003 |
[Adjuvant and palliative anticancer treatment of colon carcinoma in 2004].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cetuximab; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Colon; Colonic Neoplasms; Colorectal Neoplasms; Combined Modality Therapy; Fluorouracil; Folic Acid; Humans; Leucovorin; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Palliative Care; Postoperative Care; Randomized Controlled Trials as Topic; Time Factors | 2004 |
Chemoprevention for colon cancer: new opportunities, fact or fiction?
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Colorectal Neoplasms; Europe; Folic Acid; Humans; Inflammatory Bowel Diseases; Population Surveillance; Risk Factors; Sex Factors | 2006 |
[Adjuvant therapy in colorectal carcinomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Levamisole; Prospective Studies; Radiotherapy, Adjuvant; Rectal Neoplasms; Semustine; Vincristine | 1994 |
Folate, alcohol, methionine, and colon cancer risk: is there a unifying theme?
Topics: Alcohol Drinking; Animals; Colonic Neoplasms; DNA; Ethanol; Folic Acid; Folic Acid Deficiency; Humans; Methylation; Risk Factors; S-Adenosylmethionine | 1994 |
Folate, epithelial dysplasia and colon cancer.
Topics: Animals; Clinical Trials as Topic; Colonic Neoplasms; Epithelium; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Risk Factors | 1995 |
Nutrition and colorectal cancer.
Topics: Adenomatous Polyps; Alcohol Drinking; Animals; Calcium, Dietary; Colonic Neoplasms; Colonic Polyps; Dietary Fats; Dietary Fiber; Feeding Behavior; Folic Acid; Humans; Meat; Motor Activity; Mutagens; Nutritional Physiological Phenomena; Rectal Neoplasms; Risk Factors; Smoking; Vegetables | 1996 |
Folate and colon cancer: a fascinating puzzle we have yet to complete.
Topics: Colonic Neoplasms; Female; Folic Acid; Humans; Pregnancy | 1998 |
Folate and carcinogenesis: an integrated scheme.
Topics: Animals; Colonic Neoplasms; DNA Methylation; DNA Repair; Folic Acid; Folic Acid Deficiency; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Nucleic Acids | 2000 |
Fortifying food with folic acid.
Topics: Bread; Case-Control Studies; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Edible Grain; Europe; Flour; Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Incidence; Legislation, Food; Myocardial Ischemia; Neural Tube Defects; Nutritional Requirements; Odds Ratio; Prospective Studies; Stroke; United States | 2000 |
Chemoprevention of colon cancer.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Biomarkers, Tumor; Calcium; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Female; Folic Acid; Hematinics; Hormones; Humans; Incidence; Male; Models, Theoretical; Vitamin D | 2001 |
The future of colon cancer prevention.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Biomarkers; Calcium; Clinical Trials as Topic; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diagnostic Imaging; Disease Progression; Drug Design; Drug Synergism; Eflornithine; Enzyme Inhibitors; ErbB Receptors; Folic Acid; Forecasting; Genes, APC; Humans; Isoenzymes; Membrane Proteins; Mice; Models, Biological; Oligonucleotide Array Sequence Analysis; Ornithine Decarboxylase Inhibitors; Prostaglandin-Endoperoxide Synthases; Proteome; Risk | 2001 |
Reduced folates and fluoropyrimidine antitumor efficacy.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Folic Acid; Humans; Pyrimidines; Tumor Cells, Cultured | 1989 |
5 trial(s) available for folic acid and Colonic Neoplasms
| Article | Year |
|---|---|
Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site.
Topics: Adenomatous Polyps; Aged; Biomarkers; Body Mass Index; Colon; Colonic Neoplasms; Colonoscopy; Comet Assay; Dietary Supplements; DNA; DNA Damage; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Mucosa; Male; Middle Aged; Obesity; Polyps; Uracil; Vitamin B Complex | 2016 |
Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer.
Topics: Cell Division; Colonic Neoplasms; Colonic Polyps; Dietary Supplements; Erythrocytes; Folic Acid; Humans; Intestinal Mucosa; Rectum; Recurrence; Risk; Statistics, Nonparametric | 2002 |
Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis.
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Cholagogues and Choleretics; Cholangitis, Sclerosing; Colitis, Ulcerative; Colonic Neoplasms; Disease-Free Survival; Female; Folic Acid; Humans; Incidence; Male; Middle Aged; Risk Factors; Ursodeoxycholic Acid | 2003 |
Cost effectiveness of adding folinic acid to fluorouracil plus levamisole as adjuvant chemotherapy in patients with colon cancer in Germany.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Cost-Benefit Analysis; Female; Fluorouracil; Folic Acid; Germany; Humans; Levamisole; Male; Middle Aged; National Health Programs; Quality-Adjusted Life Years | 2003 |
[Adjuvant therapy in colorectal carcinomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Levamisole; Prospective Studies; Radiotherapy, Adjuvant; Rectal Neoplasms; Semustine; Vincristine | 1994 |
174 other study(ies) available for folic acid and Colonic Neoplasms
| Article | Year |
|---|---|
A novel dual-prodrug carried by cyclodextrin inclusion complex for the targeting treatment of colon cancer.
Topics: Animals; Antineoplastic Agents; Butyric Acid; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclodextrins; Drug Delivery Systems; Folic Acid; Male; Mesalamine; Mice; Mice, Nude; Prodrugs | 2021 |
Synthesis, physicochemical characterization, and in vitro evaluation of biodegradable PLGA nanoparticles entrapped to folic acid for targeted delivery of kaempferitrin.
Topics: Adenocarcinoma; Colonic Neoplasms; Drug Carriers; Folic Acid; Humans; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2022 |
Nanodiamond-based multifunctional platform for oral chemo-photothermal combinational therapy of orthotopic colon cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Curcumin; Drug Liberation; Folic Acid; Indoles; Mice, Inbred BALB C; Nanodiamonds; Photothermal Therapy; Polyethylene Glycols; Polymers | 2022 |
Fabrication and assessment of folic acid conjugated-chitosan modified PLGA nanoparticle for delivery of alpha terpineol in colon cancer.
Topics: Animals; Antioxidants; Chitosan; Colonic Neoplasms; Cyclohexane Monoterpenes; Drug Carriers; Folic Acid; Humans; Mice; Nanoparticles; Particle Size; Vascular Endothelial Growth Factor A | 2022 |
Bi-Functional Gold Nanorod-Protein Conjugates with Biomimetic BSA@Folic Acid Corona for Improved Tumor Targeting and Intracellular Delivery of Therapeutic Proteins in Colon Cancer 3D Spheroids.
Topics: Biomimetics; Colonic Neoplasms; Folic Acid; Gold; Humans; Nanoconjugates; Nanotubes; Ribonuclease, Pancreatic | 2022 |
Dietary methyl donor nutrients, DNA mismatch repair polymorphisms, and risk of colorectal cancer based on microsatellite instability status.
Topics: Case-Control Studies; Choline; Colonic Neoplasms; Colorectal Neoplasms; Diet; DNA Mismatch Repair; Folic Acid; Humans; Methionine; Microsatellite Instability; Niacin; Nutrients; Polymorphism, Genetic; Risk Factors | 2022 |
Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles.
Topics: Cell Line, Tumor; Cell Proliferation; Chitosan; Colonic Neoplasms; Doublecortin-Like Kinases; Folic Acid; Hesperidin; Humans; Intracellular Signaling Peptides and Proteins; Nanoparticles; Neoplastic Stem Cells; Protein Serine-Threonine Kinases | 2022 |
Microfluidized Dextran Microgels Loaded with Cisplatin/SPION Lipid Nanotherapeutics for Local Colon Cancer Treatment via Oral Administration.
Topics: Administration, Oral; Animals; Cisplatin; Colonic Neoplasms; Dextranase; Dextrans; Folic Acid; Lipids; Magnetic Iron Oxide Nanoparticles; Mice; Microgels; Nanoparticles; Protons | 2022 |
Folate decorated lipid chitosan hybrid nanoparticles of 5-fluorouracil for enhanced anticancer efficacy against colon cancer.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Folic Acid; Humans; Lipids; Nanoparticles; Particle Size | 2022 |
Folic Acid-Functionalized Albumin/Graphene Oxide Nanocomposite to Simultaneously Deliver Curcumin and 5-Fluorouracil into Human Colorectal Cancer Cells: An
Topics: Albumins; Colonic Neoplasms; Curcumin; Excipients; Fluorouracil; Folic Acid; Graphite; Humans | 2023 |
Improving Cancer Targeting: A Study on the Effect of Dual-Ligand Density on Targeting of Cells Having Differential Expression of Target Biomarkers.
Topics: Biomarkers; Caco-2 Cells; Colonic Neoplasms; Folic Acid; Humans; Hyaluronic Acid; Ligands | 2023 |
Folic acid-chitosan functionalized polymeric nanocarriers to treat colon cancer.
Topics: Animals; Caco-2 Cells; Chitosan; Colonic Neoplasms; Drug Carriers; Folic Acid; Humans; Nanoparticles; Polymers; Rats | 2023 |
The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Apoptosis; B7-H1 Antigen; Cell Proliferation; Colonic Neoplasms; Female; Folic Acid; Gene Expression Profiling; Humans; Immunotherapy; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondria; Oxygen Consumption; T-Lymphocytes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Folic acid conjugated Prussian blue nanoparticles: Synthesis, physicochemical characterization and targeted cancer cell sensing.
Topics: Biosensing Techniques; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dielectric Spectroscopy; Electrodes; Ferrocyanides; Folic Acid; Graphite; Humans; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Particle Size | 2020 |
Folate conjugation improved uptake and targeting of porous hydroxyapatite nanoparticles containing epirubicin to cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Carriers; Drug Compounding; Drug Liberation; Durapatite; Epirubicin; Female; Folic Acid; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Nanoparticles; Particle Size; Polyethylene Glycols; Porosity | 2020 |
Functionalized layer-by-layer assembled film with directional 5-fluorouracil release to target colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Caco-2 Cells; Capsules; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Colonic Neoplasms; Drug Compounding; Fluorouracil; Folic Acid; Humans; Male; Polyesters; Rabbits; Rats; Spheroids, Cellular; Xenograft Model Antitumor Assays | 2020 |
Enzymatic synthesis of PEGylated lactide-diester-diol copolyesters for highly efficient targeted anticancer drug delivery.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dioxanes; Docetaxel; Drug Carriers; Drug Compounding; Female; Folic Acid; Mice; Nanoparticles; Particle Size; Polyesters; Polyethylene Glycols; Xenograft Model Antitumor Assays | 2020 |
Tumor Targeting Effect of Triphenylphosphonium Cations and Folic Acid Coated with Zr-89-Labeled Silica Nanoparticles.
Topics: Animals; Cations; Colonic Neoplasms; Female; Folic Acid; Humans; Mice; Mice, Inbred BALB C; Nanoparticles; Organophosphorus Compounds; Positron-Emission Tomography; Radioisotopes; Radiopharmaceuticals; Silicon Dioxide; Zirconium | 2020 |
Macromolecular design of folic acid functionalized amylopectin-albumin core-shell nanogels for improved physiological stability and colon cancer cell targeted delivery of curcumin.
Topics: Albumins; Amylopectin; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Nanogels | 2020 |
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
Topics: Acetylation; Aminohydrolases; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colonic Neoplasms; Colorectal Neoplasms; Folic Acid; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Hydrolases; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Multifunctional Enzymes; Oxidation-Reduction; Sirtuin 3 | 2020 |
The Interplay between Fe
Topics: Adenocarcinoma; Antineoplastic Agents; Butyric Acid; Cell Line; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Delivery Systems; Ferric Compounds; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Magnetics; Magnetite Nanoparticles; Polyethylene Glycols | 2020 |
Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells.
Topics: A549 Cells; Annexin A5; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Delivery Systems; Drug Liberation; Folic Acid; Gold; HCT116 Cells; Humans; Hydrogen-Ion Concentration; Lung; Lung Neoplasms; Metal Nanoparticles; Methotrexate; Tumor Microenvironment | 2020 |
Folate and colon cancer: dietary habits from the distant past coming home to roost.
Topics: Colonic Neoplasms; Diet; Feeding Behavior; Folic Acid; Humans | 2021 |
Chitosan-coated Zn-metal-organic framework nanocomposites for effective targeted delivery of LNA-antisense miR-224 to colon tumor: in vitro studies.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Folic Acid; Humans; Metal-Organic Frameworks; MicroRNAs; Nanocomposites; Spectroscopy, Fourier Transform Infrared; Zinc | 2022 |
[Effect of peripheral bloodgenomic DNA methylation on the relationship between methyl donor status and risk of breast cancer].
Topics: Betaine; Breast Neoplasms; Case-Control Studies; Choline; Colonic Neoplasms; Diet; DNA Methylation; Female; Folic Acid; Humans; Methionine; Nutrition Surveys; Risk | 2017 |
Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytokines; Dietary Supplements; DNA Methylation; Epithelial Cells; Folic Acid; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HT29 Cells; Humans; Inflammation Mediators; MicroRNAs; NF-kappa B; Promoter Regions, Genetic; Tumor Necrosis Factor-alpha | 2017 |
Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bacillus coagulans; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Liberation; Folic Acid; HT29 Cells; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Rats, Sprague-Dawley; Spores, Bacterial | 2018 |
Targeted delivery of miRNA-204-5p by PEGylated polymer nanoparticles for colon cancer therapy.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Folic Acid; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; HCT116 Cells; Humans; Mice; MicroRNAs; Nanoparticles; Polyesters; Polyethylene Glycols; Xenograft Model Antitumor Assays | 2018 |
Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Fluorouracil; Folic Acid; HCT116 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Intracellular Space; Leucovorin; Mice; Pyridoxal Phosphate | 2018 |
Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Delayed-Action Preparations; Doxorubicin; Drug Liberation; Etoposide; Fluoresceins; Folic Acid; Gene Silencing; Gold; HCT116 Cells; Humans; Liposomes; Metal Nanoparticles; Mice; Oligoribonucleotides, Antisense; PC12 Cells; Photochemotherapy; Photosensitizing Agents; Rats; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Singlet Oxygen; Verteporfin; X-Rays; Xenograft Model Antitumor Assays | 2018 |
Alive attenuated Salmonella as a cargo shuttle for smart carrying of gold nanoparticles to tumour hypoxic regions.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Female; Folic Acid; Gold; Injections, Intravenous; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Salmonella typhi | 2019 |
Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Folic Acid; Glutathione; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin B 12 | 2019 |
Hyaluronic acid conjugated multi-walled carbon nanotubes for colon cancer targeting.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Folic Acid; Gemcitabine; Humans; Hyaluronic Acid; Nanotubes, Carbon; Rats | 2019 |
Smart copolymer coated SPIONs for colon cancer chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Colonic Neoplasms; Doxorubicin; Drug Delivery Systems; Folic Acid; Humans; Inulin; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Nude; Oxidation-Reduction; Polyethylene Glycols; Polymers; Thioctic Acid; Up-Regulation; Xenograft Model Antitumor Assays | 2019 |
Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo/thermotherapy delivery system for local treatment of colon cancer.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Doxorubicin; Drug Carriers; Drug Delivery Systems; Folic Acid; Hyperthermia, Induced; Lipids; Mice; Nanoparticles; Polysaccharides | 2019 |
Minicapsules encapsulating nanoparticles for targeting, apoptosis induction and treatment of colon cancer.
Topics: Animals; Apoptosis; Capsules; Caspase 3; Cell Line, Tumor; Cell Survival; Chitosan; Colonic Neoplasms; DNA Fragmentation; Folic Acid; Mice; Mice, Inbred C57BL; Nanoparticles; Staurosporine; Xenograft Model Antitumor Assays | 2019 |
Folic acid conjugated guar gum nanoparticles for targeting methotrexate to colon cancer.
Topics: Animals; Caco-2 Cells; Calorimetry, Differential Scanning; Cell Survival; Colonic Neoplasms; Cross-Linking Reagents; Drug Delivery Systems; Folic Acid; Galactans; Humans; Magnetic Resonance Spectroscopy; Mannans; Methotrexate; Nanoparticles; Particle Size; Plant Gums; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Static Electricity | 2013 |
MTHFR C677T polymorphism, folate status and colon cancer risk in acromegalic patients.
Topics: Acromegaly; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Female; Folic Acid; Humans; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nutritional Status; Pituitary Hormones; Polymorphism, Genetic; Prevalence; Risk | 2014 |
Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer.
Topics: Adult; Aged; Calcium, Dietary; Carotenoids; Case-Control Studies; Colonic Neoplasms; Diet; Dietary Carbohydrates; Dietary Fats; Energy Intake; Female; Folic Acid; Humans; JNK Mitogen-Activated Protein Kinases; Logistic Models; Lycopene; Male; MAP Kinase Signaling System; Middle Aged; Mitogen-Activated Protein Kinase 3; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rectal Neoplasms; Risk Factors; Selenium; Vegetables; Vitamin D | 2013 |
γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Folic Acid; gamma-Glutamyl Hydrolase; HCT116 Cells; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays | 2013 |
Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Biological Transport; Cell Survival; Colonic Neoplasms; Cross-Linking Reagents; Diamines; Drug Carriers; Drug Compounding; Drug Delivery Systems; Fluorouracil; Folic Acid; HT29 Cells; Humans; Inhibitory Concentration 50; Kinetics; Lactic Acid; Microscopy, Fluorescence; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties | 2015 |
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Topics: Animals; Azoxymethane; Carcinogenesis; Choline Deficiency; Colon; Colonic Neoplasms; Crosses, Genetic; Disease Models, Animal; DNA; Extracellular Matrix Proteins; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; Male; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Proteins; Protein-Lysine 6-Oxidase; Random Allocation; Thymidine Monophosphate; Tumor Burden; Uracil | 2014 |
Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon.
Topics: Capsules; Chitosan; Colon; Colonic Neoplasms; Drug Carriers; Folic Acid; Humans; Nanoparticles; Polymethacrylic Acids | 2015 |
Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of combretastatin A-4 to FR-positive tumor.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Drug Design; Female; Folate Receptors, GPI-Anchored; Folic Acid; Mice, Inbred BALB C; Molecular Structure; Optical Imaging; Photochemotherapy; Prodrugs; Stilbenes; Tissue Distribution; Xenograft Model Antitumor Assays | 2014 |
Folates Induce Colorectal Carcinoma HT29 Cell Line Proliferation Through Notch1 Signaling.
Topics: Amyloid Precursor Protein Secretases; Cell Proliferation; Colonic Neoplasms; Folate Receptor 1; Folic Acid; HT29 Cells; Humans; Receptor, Notch1; Signal Transduction; Tetrahydrofolates | 2015 |
The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Modification Methylases; Folic Acid; HCT116 Cells; Humans; Neoplastic Stem Cells; Repressor Proteins | 2015 |
RNA Nanoparticles Derived from Three-Way Junction of Phi29 Motor pRNA Are Resistant to I-125 and Cs-131 Radiation.
Topics: Animals; Bacillus Phages; Cesium Radioisotopes; Colonic Neoplasms; Folate Receptors, GPI-Anchored; Folic Acid; HT29 Cells; Humans; Injections, Subcutaneous; Iodine Radioisotopes; KB Cells; Mice; Mice, Nude; Molecular Targeted Therapy; Nanoparticles; Nucleic Acid Conformation; Radionuclide Imaging; RNA Stability; RNA, Viral; Xenograft Model Antitumor Assays | 2015 |
Folate-Modified Lipoplexes Delivering the Interleukin-12 Gene for Targeting Colon Cancer Immunogene Therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cytokines; Down-Regulation; Drug Delivery Systems; Folate Receptor 1; Folic Acid; Gene Expression Regulation, Neoplastic; Genetic Therapy; Immunotherapy; Interleukin-12; Liposomes; Mice | 2015 |
Impact of multicellular tumor spheroids as an in vivo‑like tumor model on anticancer drug response.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; HT29 Cells; Humans; Liposomes; Organoplatinum Compounds; Oxaliplatin; Spectrophotometry; Spheroids, Cellular | 2016 |
Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug Interactions; Epithelial Cells; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; HCT116 Cells; Homocysteine; Humans; Male; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Xenograft Model Antitumor Assays | 2016 |
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
Topics: Aminoimidazole Carboxamide; Carbon; Cell Compartmentation; Cell Proliferation; Colonic Neoplasms; CRISPR-Cas Systems; Cytosol; Folic Acid; Formates; Gene Knockout Techniques; Gene Library; Glycine; Glycine Hydroxymethyltransferase; HCT116 Cells; HEK293 Cells; Humans; Leucovorin; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Mutation; NADP; Ribonucleotides; Serine; Xenograft Model Antitumor Assays | 2016 |
Folic acid-decorated and PEGylated PLGA nanoparticles for improving the antitumour activity of 5-fluorouracil.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Chemistry, Pharmaceutical; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Female; Fluorouracil; Folic Acid; HT29 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Nanoparticles; Polyesters; Polyethylene Glycols; Tissue Distribution | 2017 |
Folic acid conjugated and Ag-carrying organoclay nanoparticles and their response to L929 fibroblast and DLD-1 cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Bentonite; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Carriers; Fibroblasts; Folic Acid; Humans; Nanoparticles; Silver | 2017 |
A cost-effectiveness analysis of folic acid fortification policy in the United States.
Topics: Adolescent; Adult; Aged; Colonic Neoplasms; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Edible Grain; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Health Policy; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Neural Tube Defects; Outcome Assessment, Health Care; Pregnancy; Quality-Adjusted Life Years; United States; Vitamin B 12 Deficiency; Young Adult | 2009 |
Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression.
Topics: Alcohol Drinking; Colonic Neoplasms; Diet; Female; Folic Acid; Folic Acid Deficiency; Genes, p53; Humans; Immunohistochemistry; Methionine; Middle Aged; Oligonucleotide Array Sequence Analysis; Risk Factors; Tumor Suppressor Protein p53; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex | 2008 |
DNA damage and homologous recombination signaling induced by thymidylate deprivation.
Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Nucleotides; Phosphorylation; Quinazolines; Rad51 Recombinase; Recombination, Genetic; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2008 |
The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression.
Topics: Adenosine; Anticarcinogenic Agents; Antioxidants; Caco-2 Cells; Catechin; Colonic Neoplasms; Folic Acid; Humans; I-kappa B Proteins; Leucovorin; NF-kappa B; NF-KappaB Inhibitor alpha; Proto-Oncogene Proteins c-akt; Tumor Necrosis Factor-alpha; Vitamin B Complex | 2008 |
A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status.
Topics: Colonic Neoplasms; Diet; Female; Folic Acid; Genes, ras; Humans; Incidence; Male; Microsatellite Instability; Proportional Hazards Models; Prospective Studies; Risk Factors; Vitamin B Complex | 2008 |
Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Biomarkers; Brain Chemistry; Carcinogens; Carrier Proteins; Colitis; Colonic Neoplasms; Dextran Sulfate; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; Food, Formulated; Heterozygote; Homocysteine; Intestinal Mucosa; Membrane Transport Proteins; Mice; Mice, Knockout; Models, Animal; Nutritional Status; Precancerous Conditions; Receptors, Cell Surface; Reduced Folate Carrier Protein | 2009 |
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
Topics: Blotting, Western; Breast Neoplasms; Colonic Neoplasms; CpG Islands; DNA Damage; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Risk Factors; Tumor Cells, Cultured; Uracil | 2009 |
Colon cancer in Chile before and after the start of the flour fortification program with folic acid.
Topics: Aged; Cardiovascular Diseases; Chile; Colonic Neoplasms; Female; Flour; Folic Acid; Food, Fortified; Humans; Middle Aged; Neoplasms; Patient Discharge | 2009 |
Selenium, folate, and colon cancer.
Topics: Adult; Aged; Bias; Black People; Case-Control Studies; Colonic Neoplasms; Diet; Female; Folic Acid; Humans; Life Style; Logistic Models; Male; Middle Aged; Neoplasm Staging; North Carolina; Odds Ratio; Selenium; Weight Loss; White People | 2009 |
Effect of processing on folic acid fortified Baladi bread and its possible effect on the prevention of colon cancer.
Topics: Animals; Body Weight; Bread; Carcinogens; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cooking; Diet; Dimethylhydrazines; Drug Stability; Eating; Flour; Folic Acid; Food, Fortified; Glycine max; Humidity; Intestinal Mucosa; Rats; Triticum | 2009 |
Folate intake and the risk of colorectal cancer in a Korean population.
Topics: Aged; Alcohol Drinking; Case-Control Studies; Colonic Neoplasms; Exercise; Family; Female; Folic Acid; Folic Acid Deficiency; Humans; Korea; Logistic Models; Male; Middle Aged; Odds Ratio; Pedigree; Prevalence; Rectal Neoplasms; Risk Factors; Sex Factors; Smoking; Vitamin B Complex | 2009 |
Products of the colonic microbiota mediate the effects of diet on colon cancer risk.
Topics: Aged; Biotin; Black People; Cell Division; Colon; Colonic Neoplasms; Colonoscopy; Diet; Dietary Fats; Epithelial Cells; Female; Folic Acid; Humans; Male; Middle Aged; Pennsylvania; Risk Assessment; Risk Factors; South Africa; White People | 2009 |
Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alcohol Drinking; Carcinoma; Case-Control Studies; Colonic Neoplasms; Eating; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors | 2008 |
Healthy lifestyle, including plenty of physical activity, cuts colon cancer risk.
Topics: Adult; Aged; Colonic Neoplasms; Dietary Fiber; Exercise; Female; Folic Acid; Health Knowledge, Attitudes, Practice; Health Promotion; Humans; Life Style; Middle Aged; Women's Health | 2009 |
Nanoparticulate delivery of novel drug combination regimens for the chemoprevention of colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Calcium; Cell Line, Tumor; Cell Survival; Chemoprevention; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Compounding; Drug Delivery Systems; Drug Synergism; Folic Acid; HT29 Cells; Humans; Lactic Acid; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2010 |
Colon cancer in Chile.
Topics: Chile; Colonic Neoplasms; Flour; Folic Acid; Food, Fortified; Humans; Patient Discharge | 2010 |
Epigenetic control of estrogen receptor expression and tumor suppressor genes is modulated by bioactive food compounds.
Topics: Caco-2 Cells; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Polymerase Chain Reaction; Receptors, Estrogen; Tumor Suppressor Proteins | 2010 |
Serum folate and homocysteine levels are associated with colon tumorigenesis in end-stage renal disease patients.
Topics: Adult; Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Renal Dialysis; Risk Factors; Serum | 2011 |
Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Colonic Neoplasms; Croatia; DNA Fingerprinting; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic; Risk Factors; Tetrahydrofolate Dehydrogenase | 2011 |
B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP).
Topics: Adaptor Proteins, Signal Transducing; Adult; Basic Helix-Loop-Helix Transcription Factors; Calcium Channels, T-Type; Cell Cycle Proteins; Colonic Neoplasms; Core Binding Factor Alpha 3 Subunit; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; Female; Folic Acid; Humans; Insulin-Like Growth Factor II; Kruppel-Like Transcription Factors; Methionine; Middle Aged; Mutation; MutL Protein Homolog 1; Neoplasm Proteins; Nerve Tissue Proteins; Nuclear Proteins; Poly-ADP-Ribose Binding Proteins; Polymerase Chain Reaction; Proto-Oncogene Proteins B-raf; Receptors, Retinoic Acid; Risk Factors; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Surveys and Questionnaires; Ubiquitin-Protein Ligases | 2011 |
Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Glutathione; Male; Oxidative Stress; Rats | 2011 |
Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Folic Acid; Lactic Acid; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2011 |
A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.
Topics: Animals; Antineoplastic Agents; Cell Survival; Colon; Colonic Neoplasms; Curcumin; Drug Delivery Systems; Emulsions; Flow Cytometry; Folic Acid; HeLa Cells; HT29 Cells; Humans; Rats; Solubility; Surface-Active Agents | 2012 |
Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.
Topics: Adult; Aged; Case-Control Studies; Colonic Neoplasms; Diet; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Genetic; Riboflavin; Risk Factors; Vitamin B 12; Vitamin B 6 | 2013 |
Dietary folate does not significantly affect the intestinal microbiome, inflammation or tumorigenesis in azoxymethane-dextran sodium sulphate-treated mice.
Topics: Animals; Azoxymethane; Biomarkers; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Dextrans; Diet; Disease Progression; Folic Acid; Inflammation; Male; Mice; Mice, Inbred C57BL; Microbiota; Neoplasms; RNA, Ribosomal, 16S; Sulfates | 2013 |
Dietary folate suppresses DMH-induced colon carcinogenesis in a rat model and affects DMH-induced expression of four DNA repair enzymes.
Topics: Animals; Colon; Colonic Neoplasms; Diet; Dietary Supplements; Dimethylhydrazines; DNA Damage; DNA Repair; DNA Repair Enzymes; Folic Acid; Male; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2012 |
Serum factors associated with precancerous colonic lesions in acromegaly.
Topics: Acromegaly; Adenoma; Adult; Aged; Calcifediol; Cohort Studies; Colonic Neoplasms; Colonic Polyps; Colonoscopy; Fasting; Female; Folic Acid; Homocysteine; Humans; Insulin; Male; Middle Aged; Precancerous Conditions; Somatostatin | 2013 |
Potential use of folate-appended methyl-β-cyclodextrin as an anticancer agent.
Topics: Animals; Antineoplastic Agents; beta-Cyclodextrins; Caspase 3; Caspase 7; Cell Line, Tumor; Cholesterol; Colonic Neoplasms; Doxorubicin; Folic Acid; Hemolysis; Humans; KB Cells; Male; Mice; Mice, Inbred BALB C; Rabbits; Xenograft Model Antitumor Assays | 2013 |
Folic acid lowers colon cancer risk.
Topics: Colonic Neoplasms; DNA Methylation; Drug Combinations; Family; Folic Acid; Humans; Reference Values; Vitamins | 2002 |
Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study.
Topics: Aged; Cohort Studies; Colonic Neoplasms; Diet; Female; Folic Acid; Hematinics; Humans; Incidence; Male; Middle Aged; Netherlands; Rectal Neoplasms; Risk Factors; Sex Factors | 2002 |
Dietary folate and colorectal cancer.
Topics: Adult; Alcohol Drinking; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Diet; Female; Folic Acid; Humans; Male; Methionine; Middle Aged; Rectal Neoplasms | 2002 |
Folate delivers head-to-toe health advantages. The B vitamin that benefits unborn babies may also protect the hearts and minds (and colons) of adults.
Topics: Alzheimer Disease; Anencephaly; Colonic Neoplasms; Female; Folic Acid; Heart Diseases; Homocysteine; Humans; Male; Pregnancy; Spinal Dysraphism; Stroke | 2002 |
Commentary: Colon cancer, folate and genetic status.
Topics: Colonic Neoplasms; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic | 2003 |
STUDIES ON SECRETION OF GASTRIC INTRINSIC FACTOR IN MAN.
Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Carbachol; Celiac Disease; Cobalt Isotopes; Colonic Neoplasms; Duodenal Ulcer; Folic Acid; Folic Acid Deficiency; Gastric Acidity Determination; Gastric Juice; Histamine; Humans; Insulin; Intrinsic Factor; Male; Pharmacology; Physiology; Sprue, Tropical; Vitamin B 12 | 1964 |
Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Folic Acid; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Postoperative Complications; Retrospective Studies | 2003 |
Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition.
Topics: Adenoma; Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Calcium; Colonic Neoplasms; Cross-Sectional Studies; Dietary Fats; Dietary Fiber; Environmental Exposure; Female; Folic Acid; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Male; Middle Aged; Multivariate Analysis; Risk Factors; Selenium; Smoking | 2004 |
Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Colonic Neoplasms; Culture Media, Serum-Free; Decitabine; DNA Methylation; DNA Primers; ErbB Receptors; Folic Acid; Humans; Luciferases; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolates; Transfection | 2004 |
Hyperproliferation of homocysteine-treated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate.
Topics: Caco-2 Cells; Cell Cycle; Cell Death; Cell Division; Colonic Neoplasms; Flow Cytometry; Folic Acid; Hematinics; Homocysteine; Humans; In Vitro Techniques; Tetrahydrofolates; Time Factors | 2004 |
Epigenetic events and protection from colon cancer in New Zealand.
Topics: Alcohol Drinking; Colonic Neoplasms; Dietary Fiber; DNA Methylation; Folic Acid; Genistein; Humans; Meat; Micronutrients; Models, Biological; New Zealand; Niacin; Obesity; Polymorphism, Genetic; Riboflavin; Risk Factors; Selenium; Smoking; Vitamin B 12; Vitamin B 6; Zinc | 2004 |
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Topics: Aged; Cohort Studies; Colonic Neoplasms; Diet; DNA Mutational Analysis; Female; Folic Acid; Genes, ras; Humans; Male; Middle Aged; Mutation; Neoplasms; Netherlands; Rectal Neoplasms; Risk; Sex Factors | 2005 |
Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer.
Topics: Aged; Alcohol Drinking; Case-Control Studies; Colonic Neoplasms; Diet; Female; Folic Acid; Genotype; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Rectal Neoplasms | 2005 |
Tribromomethane exposure and dietary folate deficiency in the formation of aberrant crypt foci in the colons of F344/N rats.
Topics: Animals; Body Weight; Colonic Neoplasms; Diet; Disinfectants; Dose-Response Relationship, Drug; Eating; Folic Acid; Folic Acid Deficiency; Homocysteine; Male; Rats; Rats, Inbred F344; Trihalomethanes; Water Supply | 2005 |
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured | 2006 |
5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.
Topics: Aged; Case-Control Studies; Colonic Neoplasms; Female; Folic Acid; Genotype; Hematinics; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Microsatellite Repeats; Middle Aged; Polymorphism, Genetic | 2005 |
Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenoma; Adult; Aged; Case-Control Studies; Colonic Neoplasms; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Membrane Transport Proteins; Middle Aged; Odds Ratio; Polymorphism, Genetic; Reduced Folate Carrier Protein; Thymidylate Synthase | 2005 |
Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.
Topics: Apoptosis; Colonic Neoplasms; Down-Regulation; Folic Acid; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Receptor, IGF Type 1; Tetrahydrofolates; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2006 |
The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Colonic Neoplasms; Female; Folic Acid; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Photochemotherapy; Porphyrins; Sensitivity and Specificity; Skin; Spectrometry, Fluorescence; Time Factors; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2006 |
Dietary folate and APC mutations in sporadic colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Aged; Carrier Proteins; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Diet; DNA, Neoplasm; Female; Folic Acid; Genes, APC; Humans; Male; Middle Aged; Mutation; MutL Protein Homolog 1; Nuclear Proteins; Patient Selection; Proportional Hazards Models; Rectal Neoplasms; Surveys and Questionnaires | 2006 |
High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells.
Topics: Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Epithelial Cells; Folic Acid; Gene Expression Profiling; HT29 Cells; Humans; Iron; Methionine; Oligonucleotide Array Sequence Analysis; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex | 2008 |
How to lower your risk for colon cancer. The search for answers circles back to some familiar recommendations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Body Weight; Calcium, Dietary; Colonic Neoplasms; Colonoscopy; Diet; Exercise; Folic Acid; Humans | 2007 |
An apple a day may be safer than vitamins.
Topics: Adenoma; Animals; Antioxidants; Colonic Neoplasms; Colonic Polyps; Dietary Supplements; Drug Synergism; Feeding Behavior; Folic Acid; Fruit; Humans; Malus; Neoplasms; Safety; Vegetables; Vitamins | 2008 |
Improved synthetic routes to 5,8-dideazapteroylglutamates amenable to the formation of poly-gamma-L-glutamyl derivatives.
Topics: Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Evaluation, Preclinical; Folic Acid; Humans; Indicators and Reagents; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship | 1983 |
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Folic Acid; Homocysteine; Humans; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous; Vitamin B 12 | 1982 |
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--l-leucovorin factors enhancing cytotoxic activity of 5-fluorouracil].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Leucovorin; Tegafur; Tumor Cells, Cultured; Uracil | 1995 |
Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men.
Topics: Adenoma; Adult; Aged; Alcohol Drinking; Carcinoma; Colonic Neoplasms; Diet; Folic Acid; Humans; Male; Methionine; Middle Aged; Risk Factors; Surveys and Questionnaires | 1995 |
Inhibition of progression of aberrant crypt foci and colon tumor development by vitamin E and beta-carotene in rats on a high-risk diet.
Topics: Animals; Antineoplastic Agents; beta Carotene; Carotenoids; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Folic Acid; Precancerous Conditions; Rats; Rats, Inbred F344; Vitamin E | 1995 |
Interaction of 5-fluorouracil with folates.
Topics: Aged; Colonic Neoplasms; Drug Interactions; Drug Therapy, Combination; Female; Fluorouracil; Folic Acid; Humans; Male; Middle Aged; Rectal Neoplasms | 1995 |
New therapeutic strategies for patients with gastrointestinal malignancies using biochemical modulation of fluorouracil.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Gene Expression Regulation, Enzymologic; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thymidylate Synthase | 1995 |
The high-affinity folate receptor of normal and malignant human colonic mucosa.
Topics: Carrier Proteins; Colon; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Immunoblotting; Intestinal Mucosa; Radioligand Assay; Receptors, Cell Surface | 1994 |
Inhibition of apical but not basolateral endocytosis of ricin and folate in Caco-2 cells by cytochalasin D.
Topics: Actin Cytoskeleton; Adenocarcinoma; Animals; Cell Line; Cell Polarity; Colonic Neoplasms; Cytochalasin D; Depression, Chemical; Dogs; Endocytosis; Folic Acid; Humans; Kidney; Microvilli; Neoplasm Proteins; Ricin; Tumor Cells, Cultured | 1994 |
Effect of purine synthesis inhibition on WiDr spheroids in vitro or on WiDr or colon 38 tumors in vivo. Complete growth inhibition but not regression.
Topics: Acyltransferases; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Mice; Mice, Inbred C57BL; Phosphoribosylglycinamide Formyltransferase; Purines; Tetrahydrofolates; Tumor Cells, Cultured | 1994 |
Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis.
Topics: Adult; Calcium; Carotenoids; Case-Control Studies; Cholesterol; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Erythrocytes; Female; Folic Acid; Humans; Male; Middle Aged; Precancerous Conditions; Risk Factors; Vitamins | 1993 |
The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Division; Cisplatin; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Administration Schedule; Drug Synergism; Fluorouracil; Folic Acid; Humans; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats.
Topics: Analysis of Variance; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Drug Administration Schedule; Folic Acid; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa.
Topics: Adenocarcinoma; Adenomatous Polyps; Colon; Colonic Neoplasms; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Mucosa; Reference Values | 1997 |
Clinical development plan: folic acid.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Approval; Female; Folic Acid; Humans; Male; Middle Aged; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Uterine Cervical Neoplasms | 1996 |
Markedly induced asialoGM1+CD8+ T cell production and enhancement of antimetastatic activity by interferon beta with folic or folinic acid.
Topics: Animals; Antineoplastic Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colonic Neoplasms; Drug Combinations; Folic Acid; G(M1) Ganglioside; Interferon-beta; Leucovorin; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Peritoneal Cavity | 1997 |
Are dietary factors involved in DNA methylation associated with colon cancer?
Topics: Aged; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Colonic Neoplasms; Diet; DNA Methylation; Female; Folic Acid; Humans; Male; Methionine; Middle Aged; Pyridoxine; Retrospective Studies; Risk Factors; Vitamin B 12 | 1997 |
Relationship between vitamin and calcium supplement use and colon cancer.
Topics: Adenocarcinoma; Adult; Calcium; Case-Control Studies; Colonic Neoplasms; Data Collection; Dietary Supplements; Female; Folic Acid; Humans; Logistic Models; Male; Middle Aged; Risk; Vitamins | 1997 |
Colorectal cancer--chemoprevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Folic Acid; Humans; Rectal Neoplasms; Selenium; Sulindac | 1998 |
Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study.
Topics: Adult; Colonic Neoplasms; Confounding Factors, Epidemiologic; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Incidence; Methionine; Middle Aged; Multivariate Analysis; Prospective Studies; Risk Factors; Surveys and Questionnaires; Time Factors; Vitamins | 1998 |
Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Colonic Neoplasms; Drug Resistance, Multiple; Drug Synergism; Folic Acid; Folic Acid Antagonists; Glutamates; Head and Neck Neoplasms; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Lung Neoplasms; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Trimetrexate; Tumor Cells, Cultured | 1999 |
Chemoprevention of colon cancer: have you had your multivitamin today?
Topics: Colonic Neoplasms; Female; Folic Acid; Humans; Vitamins | 1999 |
Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.
Topics: Adult; Aged; Alcohol Drinking; California; Case-Control Studies; Colonic Neoplasms; Diet; Diet Surveys; DNA Methylation; Female; Folic Acid; Genotype; Homozygote; Humans; Incidence; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Vitamin B 12 | 1999 |
[Value of multivitamin preparations and folic acid in primary prevention of colonic cancer in women].
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Diet; Dietary Fiber; Female; Folic Acid; Follow-Up Studies; Humans; Middle Aged; Primary Prevention; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Time Factors; Vitamins | 1999 |
Colon cancer prevention. Worth the trouble.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Colonic Neoplasms; Diet; Female; Folic Acid; Humans; Male; Pyrazoles; Sulfonamides; Vitamins | 1999 |
Determination of endogenous formaldehyde in plants (fruits) bound to L-arginine and its relation to the folate cycle, photosynthesis and apoptosis.
Topics: Adenocarcinoma; Apoptosis; Arginine; Chromatography, High Pressure Liquid; Colonic Neoplasms; Folic Acid; Formaldehyde; Humans; Photosynthesis; Plants; Tumor Cells, Cultured | 1998 |
Should folic acid supplementation be used to reduce the risk of cancer in ulcerative colitis?
Topics: Colitis, Ulcerative; Colonic Neoplasms; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Humans | 1999 |
Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency.
Topics: Acetaldehyde; Animals; Anti-Infective Agents; Bacteria; Ciprofloxacin; Colon; Colonic Neoplasms; Erythrocytes; Ethanol; Folic Acid; Folic Acid Deficiency; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Rats; Rats, Wistar; Risk Factors | 2000 |
Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Calcium, Dietary; Carcinogens; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Disease Models, Animal; Folic Acid; Male; Random Allocation; Rats; Rats, Inbred F344 | 1999 |
Metabolic pathway for leucovorin.
Topics: Antidotes; Colonic Neoplasms; Folic Acid; Humans; Leucovorin; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors | 2000 |
DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats.
Topics: Animals; Choline Deficiency; Colon; Colonic Neoplasms; Comet Assay; DNA; DNA Damage; DNA Methylation; Folic Acid; Folic Acid Deficiency; Liver; Male; Methionine; Rats; S-Adenosylmethionine; Vitamin B 12 | 2000 |
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Colonic Neoplasms; Fluorouracil; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leucovorin; Lung Neoplasms; Membrane Proteins; Membrane Transport Proteins; Mice; Multienzyme Complexes; Neoplasms; Peptide Synthases; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Colonic Neoplasms; Diet; Female; Folic Acid; Genes, APC; Genetic Predisposition to Disease; Intestinal Neoplasms; Intestinal Polyps; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Precancerous Conditions | 2000 |
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.
Topics: Animals; Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Data Interpretation, Statistical; Disease Models, Animal; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Injections, Subcutaneous; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Risk Factors; Time Factors | 2000 |
Multivitamins, folate, and colon cancer.
Topics: Adenocarcinoma; Adult; Colonic Neoplasms; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Risk; Vitamins | 2001 |
Folate deficiency reduces the development of colorectal cancer in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Folic Acid; Folic Acid Deficiency; Intestinal Neoplasms; Male; Rats; Rats, Sprague-Dawley | 2000 |
Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study.
Topics: Adult; Aged; Case-Control Studies; Codon; Colonic Neoplasms; Diet; DNA Methylation; Exons; Folic Acid; Genes, ras; Humans; Middle Aged; Mutation; Point Mutation; Polymerase Chain Reaction; Sequence Analysis, DNA | 2000 |
Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study.
Topics: Adult; Aged; Alcohol Drinking; Colonic Neoplasms; Diet; Female; Folic Acid; Health Surveys; Humans; Male; Methionine; Middle Aged; Nutritional Status; Risk Factors; Smoking; United States | 2001 |
Diet and cancer: one view at the start of the millennium.
Topics: Breast Neoplasms; Case-Control Studies; Colonic Neoplasms; Developing Countries; Diet; Dietary Fats; Ethnicity; Female; Folic Acid; Fruit; Humans; Life Style; Male; Prospective Studies; Risk Factors; Vegetables | 2001 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Fabulous folate.
Topics: Breast Neoplasms; Colonic Neoplasms; Coronary Disease; Dietary Supplements; Drug Interactions; Female; Folic Acid; Folic Acid Deficiency; Humans | 2001 |
The history of folic acid.
Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency | 2001 |
Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic quantities of folate.
Topics: Adenoma; Adult; Colonic Neoplasms; Diet; Dietary Supplements; Female; Folic Acid; Hematinics; Homocysteine; Humans; Intestinal Mucosa; Male; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Folic-acid-mediated inhibition of human colon-cancer cell growth.
Topics: Adenocarcinoma; Animals; Caco-2 Cells; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; DNA Methylation; Folic Acid; Humans; Tetrahydrofolates | 2001 |
Folate homeostasis and antiproliferative activity of folates and antifolates.
Topics: Animals; Caco-2 Cells; Cell Division; Colonic Neoplasms; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homeostasis; Homocysteine; Humans; Kinetics; Mice; Risk Factors | 2001 |
Is it worthwhile to try different coenzymatic forms of folate in future chemoprevention trials?
Topics: Animals; Cell Division; Clinical Trials as Topic; Colonic Neoplasms; DNA Methylation; Folic Acid; Homeostasis; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Tumor Cells, Cultured | 2001 |
A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice.
Topics: Adenoma; Animals; Body Weight; Bromodeoxyuridine; Cell Division; Choline; Colonic Neoplasms; Diet; Dietary Fats; Epithelium; Female; Folic Acid; Immunoenzyme Techniques; Intestine, Large; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Vitamin B 12 | 2001 |
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Topics: Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Ganciclovir; Gene Expression Regulation; Herpesvirus 1, Human; Humans; Methotrexate; Mice; Neoplasm Transplantation; Rats; Recombinant Fusion Proteins; Retroviridae; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Tomography, Emission-Computed; Transduction, Genetic; Transplantation, Heterologous; Trimetrexate; Tumor Cells, Cultured | 2002 |
The influence of folate and multivitamin use on the familial risk of colon cancer in women.
Topics: Adult; Alcoholic Beverages; Cohort Studies; Colonic Neoplasms; Feeding Behavior; Female; Folic Acid; Health Behavior; Humans; Methionine; Middle Aged; Prospective Studies; Risk Assessment; Risk Factors; United States; Vitamins | 2002 |
Cancer and diet. Colon vitamins.
Topics: Alcohol Drinking; Colonic Neoplasms; Diet; DNA Damage; DNA Repair; Female; Folic Acid; Humans; Methionine; United States | 2002 |
Nutritional factors in colorectal cancer risk: a case-control study in Majorca.
Topics: Case-Control Studies; Cholesterol, Dietary; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Dietary Proteins; Energy Intake; Feeding Behavior; Female; Folic Acid; Humans; Male; Rectal Neoplasms; Spain | 1991 |
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; Drug Interactions; Drug Resistance; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Interferon-gamma; RNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
Topics: Adenocarcinoma; Animals; Base Sequence; Cell Division; Cell Line; Colonic Neoplasms; Folic Acid; Humans; Kinetics; Leucovorin; Mice; Mice, Nude; Mitotic Index; Molecular Sequence Data; Mutation; Neoplasm Transplantation; Oligodeoxyribonucleotides; Phenotype; Polymerase Chain Reaction; Thymidylate Synthase; Transplantation, Heterologous; Tumor Stem Cell Assay | 1992 |
Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis.
Topics: Colitis, Ulcerative; Colon; Colonic Neoplasms; Folic Acid; Humans; Incidence | 1991 |
Interaction between 5-fluorouracil, [6RS]leucovorin, and recombinant human interferon-alpha 2a in cultured colon adenocarcinoma cells.
Topics: Adenocarcinoma; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Folic Acid; Interferon Type I; Leucovorin; Quinazolines; Recombinant Proteins; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
Folate intake and carcinogenesis of the colon and rectum.
Topics: Alcohol Drinking; Case-Control Studies; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; Food Handling; Humans; Male; New York; Rectal Neoplasms; Risk Factors; Sex Factors; Surveys and Questionnaires | 1991 |
Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Topics: Adenocarcinoma; Animals; Carrier Proteins; Cell Division; Chromatography, Gel; Colonic Neoplasms; Floxuridine; Folic Acid; Humans; Leucovorin; Leukemia L1210; Tetrahydrofolates | 1990 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase | 1987 |
Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study.
Topics: Adult; Colitis, Ulcerative; Colon; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Population Surveillance; Risk Factors; Sulfasalazine; Time Factors | 1989 |
Folate, dysplasia, and cancer.
Topics: Colitis, Ulcerative; Colon; Colonic Neoplasms; Folic Acid; Folic Acid Deficiency; Humans | 1989 |
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
Topics: Adenocarcinoma; Colonic Neoplasms; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Humans; In Vitro Techniques; Kinetics; Pteroylpolyglutamic Acids; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1989 |
The efficacy of 5-fluorouracil in human colorectal cancer is not enhanced by thymidylate synthetase inhibition with CB3717 (N10-propargyl-5,8 dideazafolic acid).
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Middle Aged; Quinazolines; Rectal Neoplasms; Thymidylate Synthase | 1988 |
Distribution and metabolism of calcium leucovorin in normal and tumor tissue.
Topics: Adenocarcinoma; Animals; Carbon-Nitrogen Ligases; Colonic Neoplasms; Folic Acid; Leucovorin; Ligases; Liver; Mice; Mice, Inbred C57BL; Reference Values | 1988 |
Selectivity of CF and 5-fluorouracil: critical role of polyglutamylation.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Leucovorin; Mice; Neoplasm Transplantation; Pteroylpolyglutamic Acids; Thymidylate Synthase; Transplantation, Heterologous | 1988 |
Characteristics of thymidylate synthase purified from a human colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Folic Acid; Humans; Kinetics; Mice; Stereoisomerism; Thymidylate Synthase; Transplantation, Heterologous | 1988 |
Phase II study of the thymidylate synthetase inhibitor CB3717 (N10-propargyl-5,8-dideazafolic acid) in colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Female; Folic Acid; Humans; Male; Middle Aged; Quinazolines; Rectal Neoplasms | 1988 |
Bioavailability of high-dose oral leucovorin.
Topics: Administration, Oral; Adult; Biological Availability; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Leucovorin; Male; Middle Aged | 1987 |
5-Fluorouracil and high-dose folic acid treatment for metastatic colon cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Female; Fluorouracil; Folic Acid; Humans; Male; Middle Aged; Neoplasm Metastasis | 1987 |
Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium.
Topics: Cell Line; Cells, Cultured; Colonic Neoplasms; Folic Acid; Humans | 1985 |
Site of reduction and methylation of folic acid in man.
Topics: Administration, Oral; Biological Assay; Biotransformation; Catheterization; Chromatography; Colonic Neoplasms; Enterococcus faecalis; Folic Acid; Hepatic Veins; Humans; Lactobacillus; Liver; Liver Cirrhosis; Methylation; Oxidation-Reduction; Pancreatic Neoplasms; Portal Vein; Tetrazolium Salts; Time Factors | 1971 |