folic acid has been researched along with Cirrhosis in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (7.81) | 29.6817 |
| 2010's | 29 (45.31) | 24.3611 |
| 2020's | 30 (46.88) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Gao, Y; Liang, H; Liu, B; Nie, J; Wen, X; Zhong, C | 1 |
| Cao, R; Chen, T; Deng, T; Guan, Y; Huang, Z; Hussain, Z; Liao, C; Liu, B; Luo, Z; Sun, J; Wang, J; Zhang, X; Zhou, Y | 1 |
| Chung, HY; Chung, KW; Ha, S; Im, DS; Jang, CW; Jeong, S; Kim, J; Yang, Y | 1 |
| Cheng, J; Jiang, B; Kong, Y; Li, C; Li, J; Liang, B; Lin, Y; Wang, W; Xu, J; Zhao, X; Zhou, N | 1 |
| Chang, YM; Chen, RJ; Chiu, PL; Ho, TJ; Huang, CY; Ju, DT; Kao, HC; Lu, CY; Su, YC; Yang, LY | 1 |
| Cao, S; Feng, J; Guan, J; Hao, J; Huang, X; Li, D; Li, X; Li, Y; Liao, Y; Liu, D; Sun, X | 1 |
| Abdul Ghani, SAB; Arul, K; Bee, GGB; Cheah, CC; Chow, PKH; Cook, SA; Lim, TR; Pei, HJ; Sandireddy, R; Shekeran, SG; Singh, BK; Singh, MK; Sinha, RA; Suzuki, A; Tikno, K; Tripathi, M; Wang, J; Widjaja, A; Wong, KA; Xiao, RP; Yen, PM; Zhang, X; Zhou, J | 1 |
| Bai, Y; Cheng, G; Du, B; Jiao, Q; Wang, Y; Yu, L; Zhao, M | 1 |
| Feng, Z; Fu, J; Hao, X; Jiao, C; Kopp, JB; Lai, E; Luan, J; Ma, C; Pi, J; Wang, Y; Zhang, B; Zhang, Y; Zhou, H; Zhu, L | 1 |
| Fu, P; Guo, F; Hu, Y; Ma, L; Ren, Q; Tao, S; Wu, C; Yang, L | 1 |
| Jiao, B; Tran, M; Wang, Y; Wen, J | 1 |
| Feng, S; Gao, Y; Liang, H; Liu, B; Nie, J; Su, X; Wen, S; Yu, W | 1 |
| Ding, JF; Sha, JM; Song, K; Sun, H; Tao, H; Tu, B; Yang, JJ; Zhang, Y; Zhao, JY; Zhou, Y | 1 |
| Kandel, R; Singh, KP | 1 |
| Chen, X; Chen, Y; Guo, J; Liang, W; Sun, D; Wang, L | 1 |
| Chen, YA; Chiang, CW; Kuo, KL; Lee, TS; Yu, CC | 1 |
| Advani, A; Advani, SL; Batchu, SN; Geldenhuys, L; Kabir, MDG; Kaur, H; Liu, Y; Poyah, P; Sedrak, P; Siddiqi, FS; Tennankore, KK; Tran, DT; Yerra, VG | 1 |
| Blasco, MA; Graña-Castro, O; Martínez, P; Saraswati, S | 1 |
| Chan, CKW; Choi, CHJ; Ding, X; Lau, JYW; Lee, LKC; Lee, TWY; Szeto, CC; Xiao, Y; Yin, B | 1 |
| Hendry, BM; Hung, G; Newbury, LJ; Sharpe, CC; Wang, JH | 1 |
| Boufaied, N; Feng, D; Gerarduzzi, C; Henley, N; Ngov, C | 1 |
| Cao, Q; Chen, J; Chen, X; Huang, C; Pollock, C; Shi, Y; Yi, H; Zhao, Y | 1 |
| Doskey, CM; Fader, KA; Fling, RR; Nault, R; Zacharewski, TR | 1 |
| Chen, P; Lin, JF; Ye, S; Zhou, X | 1 |
| Dai, Q; Hu, G; Jiang, Y; Liao, X; Meng, J; Peng, Z; Tao, L; Xie, Y; Yu, Y; Zhang, Y | 1 |
| Gao, Y; Kong, L; Sun, X; Tan, Y; Wang, S; Wang, T; Wu, X; Xu, Q; Xu, Y; Ye, J; Yuan, M; Zheng, B | 1 |
| Huang, J; Liang, H; Liang, Z; Liu, B; Nie, J; Wen, S; Yu, W | 1 |
| Fu, P; Guo, F; Huang, R; Li, L; Liu, J; Ma, L; Tan, Z; Tao, S; Zeng, X | 1 |
| Cao, P; Gao, N; Liu, Z; Wang, G; Xu, R; Zhang, W; Zhao, X | 1 |
| Ding, H; Jiang, L; Ke, Q; Luo, J; Lv, Y; Shi, C; Yang, J; Yuan, Q; Zhou, Y | 1 |
| Hakroush, S; Korsten, P; Schridde, L; Ströbel, P; Tampe, B; Tampe, D; Zeisberg, M | 1 |
| Andres-Hernando, A; Cara-Fuentes, G; Garcia, GE; Johnson, RJ; Lanaspa, M; Leamon, CP; Lu, YJ; Miyazaki, M; Miyazaki-Anzai, S; Roncal-Jiménez, CA; Truong, LD | 1 |
| Bansal, N; Bostom, A; Gabbai, F; Gutierrez, O; Hsu, CY; Hughes-Austin, J; Ix, JH; Jotwani, V; Katz, R; Levey, A; Park, M; Pfeffer, M; Sarnak, M; Shlipak, MG; Tracy, R; Weiner, D | 1 |
| Gan, X; Lu, L; Miao, N; Shen, Y; Wang, B; Xu, D; Xu, J; Xue, H; Yang, L; Zhang, W; Zhou, L | 1 |
| Hu, Z; Liang, H; Mitch, WE; Wang, Y; Yan, J; Zhang, Z | 1 |
| Boswell, S; Dadhania, VP; Gerarduzzi, C; Herbert, Z; Humphreys, BD; Iyer, A; Joshi, N; Kumar, RK; Luyendyk, JP; Trivedi, P; Vaidya, VS | 1 |
| Cai, H; Chen, J; Deng, J; Ding, Z; Dong, L; Huang, Z; Li, H; Sun, Y; Tu, X; Zang, Y; Zhang, J | 1 |
| Egido, J; Falke, LL; Goldschmeding, R; Mezzano, S; Morgado-Pascual, JL; Ortiz, A; Rayego-Mateos, S; Rodrigues-Diez, R; Rodrigues-Diez, RR; Ruiz-Ortega, M | 1 |
| Cao, Q; Chen, J; Chen, XM; Huang, C; Pollock, CA; Shi, Y; Yi, H; Zhang, L; Zhao, Y | 1 |
| Arias, M; Cannata-Ortiz, P; Egido, J; Gómez-Alamillo, C; González-Guerrero, C; Mezzano, S; Morgado-Pascual, JL; Ortiz, A; Ramos, AM; Ramos-Barron, MA; Ruiz-Ortega, M | 1 |
| Jiang, K; Lerman, LO; Macura, SI; Mishra, PK; Ponzo, TA; Tang, H | 1 |
| Adamowicz, K; Foresto-Neto, O; Honarpisheh, M; Koehler, P; Koziel, J; Kraft, F; Lech, M; Potempa, J; Steiger, S; von Rauchhaupt, E | 1 |
| Cao, J; Chen, J; Goligorsky, MS; Lin, CH; Maizel, J; Rabadi, M; Ratliff, B; Tanokuchi, R; Vasko, R; Xavier, S; Zhang, F | 1 |
| Schnellmann, RG; Stallons, LJ; Whitaker, RM | 1 |
| Ishibashi, K; Kusano, E; Morishita, Y; Muto, S; Nagata, D; Watanabe, M; Yoshizawa, H | 1 |
| Chander, PN; Chen, R; Goligorsky, MS; Maizel, J; Matsumoto, K; Vasko, R; Xavier, S; Zullo, JA | 1 |
| Arévalo, M; Boutet, A; De Frutos, CA; Grande, MT; López-Blau, C; López-Novoa, JM; Nieto, MA; Rowe, RG; Sánchez-Laorden, B; Weiss, SJ | 1 |
| Elewa, YH; Ichii, O; Kimura, J; Kon, Y; Nakamura, T; Otsuka-Kanazawa, S; Shiozuru, D | 1 |
| Bijol, V; Craciun, FL; Gerlach, CV; Kissick, HT; Pellegrini, KL; Ramachandran, K; Vaidya, VS | 1 |
| Gong, R; Jiang, C; Jin, B; Shao, Q; Xu, B; Zhang, M | 1 |
| Bank, A; Chen, J; Cooper, AJ; Feola, J; Goligorsky, MS; Johnson, GV; Lin, CH; Pihlajaniemi, TA; Ruotsalainen, HJ; Shein, J; Zhang, Z | 1 |
| Chen, S; Chen, X; Chen, Z; Mao, Z; Mei, C; Ruan, M; Wu, M; Yang, B; Zhang, L | 1 |
| Ayyadevara, S; Duffield, JS; Lambris, JD; Landes, SG; Megyesi, J; Portilla, D; Reis, ES; Sahu, RK; Stallcup, WB; Taylor, RP; Xavier, S; Yu, J | 1 |
| Ali, I; Bingham, V; Brazil, DP; Church, RH; Dunne, PD; Goldschmeding, R; Hombrebueno, JR; Kok, HM; Krishnakumar, A; Lavin, D; Martin, F; Tate, M | 1 |
| Basile, DP | 1 |
| Bramlage, C; Cohen, CD; Koschnick, S; Koziolek, MJ; Müller, GA; Patschan, D; Schmid, H; Strutz, F; Vasko, R; Zapf, A | 1 |
| Kolatsi-Joannou, M; Long, DA; Price, KL; Winyard, PJ | 1 |
| Bishop, JV; Chedwick, LR; Kellum, JA; Li, Y; Peng, Z; Singbartl, K; Wang, H; Wen, X | 1 |
| Abe, K; Fujino, T; Hasebe, N; Kabara, M; Kashiwagi, H; Kawabe, J; Kikuchi, K; Kojima, F; Nakagawa, N; Narumiya, S; Sugimoto, Y; Takahata, O; Ushikubi, F; Yuhki, K | 1 |
| Dai, J; Li, X; Qiu, Y; Zhang, X | 1 |
| Doi, K; Fujita, T; Ishii, S; Kihara, Y; Kita, Y; Nakao, A; Negishi, K; Noiri, E; Okamoto, K; Shimizu, T; Suzuki, Y; Toda, A; Yokomizo, T | 1 |
| Ardura, JA; Barat, A; Bosch, RJ; Esbrit, P; Esteban, V; Gazapo, R; Ortega, A; Rámila, D; Ruiz-Ortega, M | 1 |
| Gannon, CM; Gnudi, L; Ioffe, E; Long, DA; Price, KL; Rudge, JS; White, KE; Woolf, AS; Yancopoulos, GD | 1 |
| Bower, JD; Miller, A; Mujumdar, V; Palmer, L; Tyagi, SC | 1 |
1 trial(s) available for folic acid and Cirrhosis
| Article | Year |
|---|---|
Urinary Markers of Fibrosis and Risk of Cardiovascular Events and Death in Kidney Transplant Recipients: The FAVORIT Trial.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Female; Fibrosis; Folic Acid; Humans; Kidney Transplantation; Male; Middle Aged; Nephritis, Interstitial; Risk Factors | 2017 |
63 other study(ies) available for folic acid and Cirrhosis
| Article | Year |
|---|---|
IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Cell Transdifferentiation; Cells, Cultured; Cytokines; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Fibrosis; Folic Acid; Inflammation Mediators; Interferon Regulatory Factors; Kidney; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Nephritis; Renal Insufficiency, Chronic | 2021 |
MHC class II in renal tubules plays an essential role in renal fibrosis.
Topics: Animals; Antigen Presentation; CD4-Positive T-Lymphocytes; Cell Proliferation; Epithelial Cells; Fibrosis; Folic Acid; Histocompatibility Antigens Class II; Humans; Immunomodulation; Kidney Tubules, Proximal; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Renal Insufficiency, Chronic; T-Lymphocytes, Regulatory; Up-Regulation | 2021 |
Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses.
Topics: Adenine; Animals; Cytokines; Disease Models, Animal; Fibrosis; Folic Acid; Inflammation; Male; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic | 2021 |
Mechanosensitive Piezo1 channels mediate renal fibrosis.
Topics: Animals; Calcium; Fibrosis; Folic Acid; Integrin beta1; Ion Channels; Kidney Diseases; Mice; Ureteral Obstruction | 2022 |
Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis.
Topics: Aged; Alzheimer Disease; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Folic Acid; Humans; Leucovorin; Mice; Mice, Transgenic | 2022 |
Shenkang injection protects against renal fibrosis by reducing perforin expression through the STING/TBK1/IRF3 signaling pathways in natural killer cells.
Topics: Animals; Drugs, Chinese Herbal; Fibrosis; Folic Acid; Humans; Interferon Regulatory Factor-3; Interferons; Killer Cells, Natural; Membrane Proteins; Mice; Perforin; Protein Serine-Threonine Kinases; Renal Insufficiency, Chronic; Signal Transduction | 2022 |
Vitamin B
Topics: Animals; Fatty Acids; Fibrosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Qa-SNARE Proteins; Vitamin B 12; Vitamins | 2022 |
Folic acid-targeted pluronic F127 micelles improve oxidative stress and inhibit fibrosis for increasing AKI efficacy.
Topics: Acute Kidney Injury; Apoptosis; Cisplatin; Curcumin; Fibrosis; Folic Acid; Humans; Micelles; Oxidative Stress; Poloxamer; Resveratrol | 2022 |
LNA-anti-miR-150 alleviates renal interstitial fibrosis by reducing pro-inflammatory M1/M2 macrophage polarization.
Topics: Animals; Antagomirs; Cytokines; Fibrosis; Folic Acid; Humans; Kidney Diseases; Macrophages; Mice; MicroRNAs; Suppressor of Cytokine Signaling Proteins | 2022 |
Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism.
Topics: Animals; Biological Products; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibronectins; Fibrosis; Folic Acid; Histones; Kidney; Kidney Diseases; Mice; RNA, Small Interfering; Transforming Growth Factor beta1; Ureteral Obstruction; Xanthenes; Xanthones | 2022 |
Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis.
Topics: Animals; Collagen; Fibroblasts; Fibrosis; Folic Acid; Kidney Diseases; Mice; Renal Insufficiency, Chronic; S100 Calcium-Binding Protein A4; Transforming Growth Factor beta1 | 2022 |
Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis.
Topics: Actins; Animals; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Fibrosis; Folic Acid; Interferon Regulatory Factors; Interleukin-4; Jumonji Domain-Containing Histone Demethylases; Macrophages; Mice; Myofibroblasts; Renal Insufficiency, Chronic | 2022 |
MTHFR epigenetic derepression protects against diabetes cardiac fibrosis.
Topics: Animals; Diabetes Mellitus; DNA Methylation; Epigenesis, Genetic; Fibrosis; Folic Acid; Methylenetetrahydrofolate Reductase (NADPH2); Mice | 2022 |
Higher Concentrations of Folic Acid Cause Oxidative Stress, Acute Cytotoxicity, and Long-Term Fibrogenic Changes in Kidney Epithelial Cells.
Topics: Acetylcysteine; Animals; Antioxidants; Epithelial Cells; Fibrosis; Folic Acid; Humans; Kidney; Mice; Oxidative Stress; Reactive Oxygen Species | 2022 |
Anlotinib Alleviates Renal Fibrosis via Inhibition of the ERK and AKT Signaling Pathways.
Topics: Animals; Fibrosis; Folic Acid; Humans; Kidney Diseases; Mice; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta1; Ureteral Obstruction | 2023 |
Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase.
Topics: Animals; Fibrosis; Folic Acid; Glycine N-Methyltransferase; Humans; Kidney; Kidney Diseases; Liver; Mice; S-Adenosylmethionine; Ureteral Obstruction | 2023 |
Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Diabetes Mellitus, Experimental; Doxorubicin; Fibroblasts; Fibrosis; Folic Acid; Humans; Kidney; Kidney Diseases; Mice; Mice, Inbred C57BL; Receptors, G-Protein-Coupled; Renal Insufficiency, Chronic; Transcription Factors; Ureteral Obstruction | 2023 |
Short and dysfunctional telomeres sensitize the kidneys to develop fibrosis.
Topics: Animals; Fibrosis; Folic Acid; Humans; Kidney; Mice; Shelterin Complex; Telomerase; Telomere | 2021 |
A sub-10-nm, folic acid-conjugated gold nanoparticle as self-therapeutic treatment of tubulointerstitial fibrosis.
Topics: Animals; Fibrosis; Folic Acid; Gold; Kidney; Metal Nanoparticles; Mice; Renal Insufficiency, Chronic | 2023 |
Inhibition of Kirsten-Ras reduces fibrosis and protects against renal dysfunction in a mouse model of chronic folic acid nephropathy.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibrosis; Folic Acid; Gene Knockdown Techniques; Jagged-1 Protein; Kidney; Male; Mice; Polymerase Chain Reaction; Proto-Oncogene Proteins p21(ras); Renal Insufficiency, Chronic | 2019 |
Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney Injury.
Topics: Animals; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Folic Acid; Gene Expression Profiling; Gene Expression Regulation; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Ureteral Obstruction; Vitamin B Complex | 2019 |
RIPK3 blockade attenuates kidney fibrosis in a folic acid model of renal injury.
Topics: Animals; Disease Models, Animal; Fibrosis; Folic Acid; Imidazoles; Inflammasomes; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Oximes; Receptor-Interacting Protein Serine-Threonine Kinases; Renal Insufficiency, Chronic | 2020 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.
Topics: Adenosylhomocysteinase; Animals; Betaine-Homocysteine S-Methyltransferase; Carbon; Disease Progression; Fibrosis; Folic Acid; Glycine N-Methyltransferase; Liver; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Polychlorinated Dibenzodioxins | 2020 |
Folic acid attenuates remodeling and dysfunction in the aging heart through the ER stress pathway.
Topics: Aging; Animals; Cardiotonic Agents; Cell Line; Endoplasmic Reticulum Stress; Fibrosis; Folic Acid; Heart; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Systole; Ventricular Remodeling | 2021 |
Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.
Topics: Animals; Disease Models, Animal; Extracellular Matrix; Fibrosis; Folic Acid; Inflammasomes; Kidney; Kidney Diseases; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Pyridones; Reactive Oxygen Species | 2021 |
Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation.
Topics: Animals; Benzofurans; CELF1 Protein; Cell Line; Disease Models, Animal; Fibroblasts; Fibrosis; Folic Acid; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Rats; Transforming Growth Factor beta1 | 2021 |
Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury.
Topics: Animals; Enzyme Inhibitors; Fibroblasts; Fibrosis; Folic Acid; Histone-Lysine N-Methyltransferase; Isoquinolines; Kidney; Kidney Diseases; Kidney Function Tests; Lectins, C-Type; Macrophages; Male; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Receptors, Cell Surface; Sulfonamides; Transcription Factor RelA | 2021 |
Genetic and pharmacological inhibition of fatty acid-binding protein 4 alleviated inflammation and early fibrosis after toxin induced kidney injury.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Biphenyl Compounds; Carcinogens; Disease Models, Animal; Fatty Acid-Binding Proteins; Fibrosis; Folic Acid; Hematinics; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; RNA, Small Interfering | 2021 |
Low Dose of Folic Acid Can Ameliorate Hyperhomocysteinemia-Induced Cardiac Fibrosis and Diastolic Dysfunction in Spontaneously Hypertensive Rats.
Topics: Animals; Diastole; Drug Evaluation, Preclinical; Fibrosis; Folic Acid; Heart; Heart Diseases; Hematinics; Hyperhomocysteinemia; Hypertension; Male; Myocardium; Random Allocation; Rats, Inbred SHR | 2021 |
CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair.
Topics: Adenosine Triphosphate; Animals; Blood Urea Nitrogen; Carnitine O-Palmitoyltransferase; Cell Respiration; Cells, Cultured; Creatinine; Fibrosis; Folic Acid; Kidney Diseases; Kidney Tubules; Lipid Metabolism; Male; Mice, Inbred C57BL; Mitochondria; Phenotype | 2021 |
Different Patterns of Kidney Fibrosis Are Indicative of Injury to Distinct Renal Compartments.
Topics: Aged; Animals; Collagen; Disease Models, Animal; Extracellular Matrix; Female; Fibrosis; Folic Acid; Humans; Kidney; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Male; Mice, Inbred C57BL; Middle Aged; Nephritis; Prognosis; Retrospective Studies; Transcriptome; Ureteral Obstruction | 2021 |
A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats.
Topics: Aminopterin; Animals; Fibrosis; Folate Receptor 2; Folic Acid; Glomerulonephritis; Inflammation; Macrophages; Methotrexate; Rats | 2021 |
c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling.
Topics: Angiotensin II; Animals; Extracellular Matrix; Fibroblasts; Fibrosis; Folic Acid; Integrin alphaV; Kidney; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-myc; Renal Insufficiency, Chronic; Signal Transduction; Thiazoles; Transforming Growth Factor beta; Up-Regulation; Ureteral Obstruction | 2017 |
The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis.
Topics: Actins; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Folic Acid; Humans; Kidney; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Monocytes; Receptors, Cell Surface; Renal Insufficiency, Chronic; Signal Transduction; STAT6 Transcription Factor; Th2 Cells | 2017 |
Targeting Phospholipase D4 Attenuates Kidney Fibrosis.
Topics: Animals; Extracellular Matrix; Fibrosis; Folic Acid; Gene Library; Gene Silencing; Glycoproteins; HEK293 Cells; Humans; Immune System; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipase D; Receptor, trkA; RNA, Small Interfering; Signal Transduction; Up-Regulation | 2017 |
TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis.
Topics: Animals; Fibroblasts; Fibrosis; Folic Acid; HEK293 Cells; Humans; Kidney; Mice; Mice, Inbred C57BL; MicroRNAs; Rats; SOX9 Transcription Factor; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2018 |
Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation.
Topics: Animals; Connective Tissue Growth Factor; Disease Models, Animal; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Fibroblasts; Fibrosis; Folic Acid; G2 Phase Cell Cycle Checkpoints; Humans; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; NIH 3T3 Cells; Peptide Fragments; Protein Kinase Inhibitors; Receptor, trkA; Signal Transduction; STAT3 Transcription Factor | 2018 |
Metformin attenuates folic-acid induced renal fibrosis in mice.
Topics: Albuminuria; Animals; Cell Line; Chemokine CCL2; Collagen Type IV; Disease Models, Animal; Extracellular Matrix; Fibronectins; Fibrosis; Folic Acid; Gene Expression Regulation; Humans; Inflammation; Kidney; Kidney Tubules, Proximal; Male; MAP Kinase Signaling System; Metformin; Mice, Inbred C57BL; Smad3 Protein; Transforming Growth Factor beta1 | 2018 |
CCL20 blockade increases the severity of nephrotoxic folic acid-induced acute kidney injury.
Topics: Acute Kidney Injury; Adult; Aged; Animals; Antibodies, Neutralizing; Case-Control Studies; Cell Line; Chemokine CCL20; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Fibrosis; Folic Acid; Gene Expression Profiling; Humans; Immunity, Innate; Kidney Tubules; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Receptors, CCR6; Severity of Illness Index; Signal Transduction; Systems Biology; T-Lymphocytes, Regulatory; Th17 Cells; Young Adult | 2018 |
Multiparametric MRI detects longitudinal evolution of folic acid-induced nephropathy in mice.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Disease Progression; Fibrosis; Folic Acid; Glomerular Filtration Rate; Kidney; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Necrosis; Organ Size; Predictive Value of Tests; Renal Circulation; Time Factors | 2018 |
Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Cisplatin; Disease Models, Animal; Female; Fibrosis; Folic Acid; Kidney; Kidney Diseases; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Renal Insufficiency, Chronic | 2018 |
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Topics: Acute Kidney Injury; Animals; Cellular Senescence; Concanavalin A; Down-Regulation; Endothelium, Vascular; Exons; Extracellular Matrix; Fibrosis; Folic Acid; Gene Expression Regulation, Enzymologic; Human Umbilical Vein Endothelial Cells; Kidney; Kidney Failure, Chronic; Male; Matrix Metalloproteinase 14; Mice; Mice, Mutant Strains; Mice, Transgenic; Neovascularization, Physiologic; Nephrosclerosis; Regeneration; Sirtuin 1; Vasodilation | 2014 |
Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis.
Topics: Actins; Acute Kidney Injury; Animals; Blotting, Western; Collagen; Creatinine; DNA; Electron Transport Complex IV; Fibrosis; Folic Acid; Glycosuria; Hematinics; Homeostasis; Male; Mice; Mitochondria; Mitochondrial Diseases; RNA, Messenger | 2014 |
siRNAs targeted to Smad4 prevent renal fibrosis in vivo.
Topics: Animals; Fibrosis; Folic Acid; Gene Expression Regulation; Genetic Therapy; Humans; Mice; Myofibroblasts; RNA, Small Interfering; Smad4 Protein | 2014 |
Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD.
Topics: Animals; Cell Transdifferentiation; Endoglin; Endothelium; Fibrosis; Folic Acid; Intracellular Signaling Peptides and Proteins; Kidney; Mice, Transgenic; Neovascularization, Physiologic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Renal Insufficiency, Chronic; Smad Proteins; Transforming Growth Factor beta; Ureteral Obstruction | 2015 |
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Folic Acid; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Snail Family Transcription Factors; Transcription Factors; Ureteral Obstruction | 2015 |
MRL/MpJ mice show unique pathological features after experimental kidney injury.
Topics: Acute Kidney Injury; Animals; Calcinosis; Disease Models, Animal; Fibrosis; Folic Acid; Kidney; Kidney Diseases; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenotype; Transforming Growth Factor beta1; Wound Healing | 2016 |
Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis.
Topics: Acute Kidney Injury; Animals; Fibrosis; Folic Acid; In Situ Hybridization; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred BALB C; MicroRNAs; RNA | 2016 |
Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment.
Topics: Abietanes; Acute Kidney Injury; Animals; Fibrosis; Folic Acid; Kidney; Mice; Mice, Inbred C57BL | 2015 |
Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.
Topics: Aging; Animals; Cells, Cultured; Cellular Senescence; Collagen Type XVIII; Endostatins; Endothelial Cells; Extracellular Matrix Proteins; Fibrosis; Folic Acid; GTP-Binding Proteins; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Glutamine gamma Glutamyltransferase 2; Transglutaminases; Up-Regulation | 2016 |
PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury.
Topics: Actins; Acute Kidney Injury; Animals; Cell Line; Collagen Type I; Fibroblasts; Fibrosis; Folic Acid; Mice; Mice, Inbred C57BL; Platelet-Derived Growth Factor; Rats; Receptor, Platelet-Derived Growth Factor alpha; Smad3 Protein; Transcription Factors; Transforming Growth Factor beta; Up-Regulation | 2017 |
Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.
Topics: Animals; Cell Communication; Complement Activation; Complement C1q; Complement C3; Cytokines; Disease Models, Animal; Disease Progression; Extracellular Matrix Proteins; Fibrosis; Folic Acid; Genotype; Inflammation Mediators; Kidney Tubules; Leukocyte Common Antigens; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Pericytes; Phenotype; Receptor, Platelet-Derived Growth Factor beta; Renal Insufficiency, Chronic; Time Factors; Ureteral Obstruction; Wnt Signaling Pathway; Wnt3A Protein | 2017 |
Gremlin1 plays a key role in kidney development and renal fibrosis.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Fibrosis; Folic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Mice, Inbred C57BL; Mice, Knockout; Organogenesis; Phenotype; Signal Transduction; Time Factors; Urogenital Abnormalities | 2017 |
Challenges of targeting vascular stability in acute kidney injury.
Topics: Acute Kidney Injury; Angiopoietin-1; Animals; Endothelium, Vascular; Fibrosis; Folic Acid; Humans; Neovascularization, Physiologic; Renal Circulation | 2008 |
Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure.
Topics: Animals; Calcium-Binding Proteins; Cell Line; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Cytokines; Disease Models, Animal; Disease Progression; Female; Fibrosis; Folic Acid; Humans; Kidney Tubules, Distal; Kidney Tubules, Proximal; Mice; Mice, Inbred Strains; Reactive Oxygen Species; Renal Insufficiency; S100 Calcium-Binding Protein A4; S100 Proteins | 2010 |
Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Body Weight; Cell Proliferation; Citrus; Cytokines; Fibrosis; Folic Acid; Galectin 3; Kidney Function Tests; Mice; Mice, Inbred C57BL; Organ Size; Pectins; Phytotherapy; Up-Regulation | 2011 |
One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Blood Urea Nitrogen; Creatinine; Cyclosporine; Cytokine TWEAK; Disease Models, Animal; Fibrosis; Folic Acid; Immunosuppressive Agents; Interleukin-6; Lipocalin-2; Lipocalins; Male; Mice; NF-kappa B; Oncogene Proteins; Tumor Necrosis Factors | 2012 |
The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Connective Tissue Growth Factor; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epithelial Cells; Fibrosis; Folic Acid; Gene Expression Regulation; Heptanoates; Kidney Diseases; Kidney Tubules; Macrophages; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor beta1; Ureteral Obstruction | 2012 |
4-1BB-mediated signals confer protection against folic acid-induced nephrotoxicity.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Fibrosis; Folic Acid; Immune System; Kidney Diseases; Kidney Tubules; Male; Mice; Mice, Inbred Strains; Signal Transduction; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 9 | 2012 |
Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.
Topics: Animals; Chemokine CCL2; Chemotaxis; Fibrosis; Folic Acid; Inflammation; Kidney Diseases; Leukocytes; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity.
Topics: Actins; Animals; Apoptosis; Cell Proliferation; Extracellular Matrix; Fibrosis; Folic Acid; Kidney; Kidney Tubules; Macrophages; Mice; Mice, Transgenic; Muscle, Smooth; Parathyroid Hormone-Related Protein; Rats | 2006 |
Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury.
Topics: Adenoviridae; Angiopoietin-1; Animals; Disease Models, Animal; Fibrosis; Folic Acid; Genetic Vectors; Inflammation; Kidney Diseases; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Renal Circulation | 2008 |
Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats.
Topics: Animals; Electrocardiography; Endocardium; Endothelium, Vascular; Fibrosis; Folic Acid; Heart Ventricles; Homocysteine; Hypertension; Hypertrophy, Left Ventricular; Matrix Metalloproteinases; Myocardium; Rats; Rats, Inbred SHR; Rats, Wistar; Ventricular Function, Left | 2002 |