Compounds > folic acid
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folic acid and Carcinoma, Non-Small Cell Lung

folic acid has been researched along with Carcinoma, Non-Small Cell Lung in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.85)18.2507
2000's13 (24.07)29.6817
2010's26 (48.15)24.3611
2020's14 (25.93)2.80

Authors

AuthorsStudies
Chen, D; Hu, Y; Low, PS; Napoleon, JV; Savran, CA; Singhal, S; Srinivasarao, M1
Chen, J; Huang, L; Li, X; Lin, J; Tu, Y; Zheng, R1
Ahlawat, P; Bal, A; Phutela, K; Sharma, S; Singh, N1
Baudouin, A; Beaurain, M; Couraud, S; Herledan, C; Ranchon, F; Rioufol, C; Souquet, PJ; Teixeira, A; Vantard, N1
El-Brolsy, HMEM; El-Kemary, MA; Hanafy, NAN1
Chen, JS; Chen, TE; Chen, YC; Cheng, ML; Huang, RS; Lin, YS; Lynn, KS; Shah, P1
Buddolla, V; Kim, YJ; Lakshmi, BA; Varaganti, P1
Hashimoto, M; Hirano, S; Katsuya, Y; Kobayashi, K; Naka, G; Suzuki, M; Takeda, Y; Uemura, Y1
Bhosle, J; Gunapala, R; Hodgkiss, A; Kumar, R; Mak, D; Minchom, A; O'Brien, MER; Popat, S; Walder, D; Yousaf, N1
Ai, Y; Du, X; Song, Y; Wang, Y; Xia, Z; Zhang, J; Zhao, G; Zhou, B1
Banerjee, S; Banerji, U; Cojocaru, E; Scaranti, M1
Feng, H; Li, G; Liu, Y; Tan, G; Wang, Y; Xing, W; Xu, Z1
Badanthadka, M; Chokshi, N; Khatri, H; Patel, BM; Patel, MM; Rawal, S1
Aydin, C; Esendagli, G; Karpuz, M; Ozer, AY; Ozturk, SC; Silindir-Gunay, M; Tuncel, M; Yanik, H1
Chang, YC; Chou, YT; Ho, CT; Hsiao, SH; Liu, JJ; Shen, PW1
Kasinski, AL; Low, PS; Lyle, LT; Orellana, EA; Rangasamy, L; Tenneti, S1
Alnatsha, A; Calleja-Hernández, MÁ; Cañadas-Garre, M; Faus-Dáder, MJ; Pérez-Ramírez, C; Valdivia-Bautista, J; Villar, E1
Chang, GC; Chiu, LY; Hsu, SL; Huang, YR; Sheu, GT; Yang, TY1
Belinsky, SA; Bruse, SE; Flores, KG; Gauderman, WJ; Gilliland, FD; Leng, S; Liu, Y; Picchi, MA; Stidley, CA; Thomas, CL; Van Den Berg, D; Zhang, X1
Caddick, S; Cal, PM; Chudasama, V; Cordeiro, C; Frade, RF; Gois, PM1
Bacus, SS; Moran, DM; Paz, K; Pry, K; Sidransky, D; Trusk, PB1
Aggarwal, AN; Behera, D; Kaur, J; Singh, N1
Hosomi, Y; Iguchi, M; Nagamata, M; Nakahara, Y; Okamoto, H; Okamura, T; Okuma, Y; Shibuya, M; Shimokawa, T; Sunami, K; Takagi, Y; Yomota, M1
Horai, T; Horiike, A; Kudo, K; Nishio, M; Ohyanagi, F; Saito, R; Sakatani, T; Tanaka, H; Yanagitani, N1
Chohnabayashi, N; Gotoh, K; Jinta, T; Kitamura, A; Koyama, K; Nishimura, N; Ohde, S; Okafuji, K; Takayama, S; Tomishima, Y; Tsuda, Y; Yagi, N1
Behera, D; Maturu, VN; Singh, N1
Hosomi, Y; Okamoto, H; Shibuya, M; Takagi, Y1
Berezowska, S; Dorn, P; Froment, L; Hall, SR; Kocher, G; Liang, SQ; Marti, TM; Peng, RW; Schmid, RA1
He, Z; Huang, C; Huang, J; Sun, W; Teng, Y; Wu, Y; Xu, Y; Zhang, H; Zhang, X1
Chen, W; He, Z; Huang, J; Ma, J; Shi, Z; Sun, W; Xia, J; Zhang, X1
Hosomi, Y; Nagamata, M; Nakahara, Y; Okamura, T; Okuma, Y; Shimokawa, T; Sunami, K; Takagi, Y; Takahashi, S; Watanabe, K; Yomota, M1
Aggarwal, C; Alley, EW; Bagley, SJ; Blair, IA; Cohen, RB; Evans, TL; Langer, CJ; Vachani, A; Vitale, S; Whitehead, AS; Zhang, S1
Hu, LL; Li, ZP; Liu, J; Wang, AW; Wang, ZD; Zhao, QS1
Baldi, M; Behera, D; Kapoor, R; Kaur, J; Singh, N1
Banerjee, T; Heckert, B; Kallu, J; Naz, S; Santra, S; Shelby, T; Sulthana, S; Vuppala, SR; Yambem, O1
Adachi, S; Fujimoto, T; Fukuoka, M; Ichinose, Y; Kubota, K; Nakagawa, K; Nambu, Y; Nishiwaki, Y; Ohe, Y; Saijo, N; Tamura, T; Yamamoto, N1
Bearz, A; Pampaloni, G; Russo, F1
Fukui, Y; Jin, M; Kawakami, K; Minamoto, T; Oda, M; Oka, T; Takechi, T; Tsukioka, S; Watanabe, G1
Bosch-Barrera, J; Ceballos, J; Ferrer, M; García-Foncillas, J; Gaztañaga, M; Gil-Bazo, I; Idoate, MA; López-Picazo, JM; Pérez-Gracia, JL; Pretel, M; Sanz, ML1
Barata, F; Barlesi, F; Bearz, A; Bepler, G; Chiappori, A; Chouaki, N; Iscoe, N; Liepa, AM; Park, K; Reck, M; Scagliotti, G; Soria, JC; von Pawel, J; Wagle, A; Zhao, YD1
Azzoli, CG; Dunne, M; Ginsberg, M; Huntington, M; James, L; Kris, MG; Krug, LM; May, J; Miller, V; Patel, JD; Saunders, M; Sirotnak, FM; Subzwari, S; Tyson, L1
Desmoulin, SK; Gangjee, A; Hou, Z; Matherly, LH1
Igawa, S; Katono, K; Maki, S; Masuda, N; Otani, S; Ryuge, S; Sasaki, J; Sato, Y; Takakura, A; Wada, M1
Hassan, R; Maltzman, J; Thomas, A1
Adjei, AA1
Budde, LS; Hanna, NH1
Scagliotti, GV1
Bridle, H; Eisen, T; El Galta, R; Houlston, RS; Matakidou, A; Rudd, MF; Webb, EL1
Chattopadhyay, S; Goldman, ID; Min, SH; Tamari, R; Tsai, E; Zhao, R1
Clarke, SJ; Li, KM; Rivory, LP1
Daly, BD; Jatoi, A; Kramer, G; Mason, JB2
Backus, HH; Jansen, G; Molders, N; Padrón, JM; Peters, GJ; Pinedo, HM; van Der Wilt, CL; van Groeningen, CJ; Wouters, D1
Bunn, PA1

Reviews

7 review(s) available for folic acid and Carcinoma, Non-Small Cell Lung

ArticleYear
Recent advances in using folate receptor 1 (FOLR1) for cancer diagnosis and treatment, with an emphasis on cancers that affect women.
    Life sciences, 2023, Aug-01, Volume: 326

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Folate Receptor 1; Folic Acid; Humans; Lung Neoplasms; Ovarian Neoplasms

2023
Exploiting the folate receptor α in oncology.
    Nature reviews. Clinical oncology, 2020, Volume: 17, Issue:6

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Female; Fluorescent Dyes; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Humans; Immunoconjugates; Immunologic Factors; Immunotherapy, Adoptive; Lung Neoplasms; Maytansine; Mesothelioma; Molecular Imaging; Molecular Targeted Therapy; Neoplasms; Optical Imaging; Ovarian Neoplasms; Radionuclide Imaging; Theranostic Nanomedicine; Tubulin Modulators

2020
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.
    Cancer biology & therapy, 2012, Volume: 13, Issue:14

    Topics: Biological Transport; Carcinoma, Non-Small-Cell Lung; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Molecular Targeted Therapy; Neoplasms; Pemetrexed; Proton-Coupled Folate Transporter

2012
Farletuzumab in lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2013, Volume: 80, Issue:1

    Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Folate Receptor 1; Folic Acid; Humans; Lung Neoplasms

2013
Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Neoplasms; Pemetrexed; Platinum Compounds; Thymidylate Synthase; Vitamin B 12

2004
Antimetabolites in the management of non-small cell lung cancer.
    Current treatment options in oncology, 2005, Volume: 6, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Survival; Treatment Outcome

2005
Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors).
    Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Pleural Neoplasms; Thymidylate Synthase; Vitamin B 12

2002

Trials

8 trial(s) available for folic acid and Carcinoma, Non-Small Cell Lung

ArticleYear
A prospective study of shortened vitamin supplementation prior to cisplatin-pemetrexed therapy for non-small cell lung cancer.
    The oncologist, 2014, Volume: 19, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Pemetrexed; Prospective Studies; Treatment Outcome; Vitamin B 12

2014
Phase II study of oral vitamin B12 supplementation as an alternative to intramuscular injection for patients with non-small cell lung cancer undergoing pemetrexed therapy.
    Cancer chemotherapy and pharmacology, 2016, Volume: 77, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Homocysteine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex

2016
Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer.
    Clinical lung cancer, 2017, Volume: 18, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Prognosis; Prospective Studies; Survival Rate; Vitamin B Complex

2017
Rationale and Design of PEMVITASTART-An Open-label Randomized Trial Comparing Simultaneous Versus Standard Initiation of Vitamin B
    Clinical lung cancer, 2017, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dietary Supplements; Female; Folic Acid; Humans; Lung Neoplasms; Male; Middle Aged; Patient Selection; Pemetrexed; Prospective Studies; Research Design; Treatment Outcome; Vitamin B 12; Young Adult

2017
Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jul-01, Volume: 14, Issue:13

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Regression Analysis; Safety; Treatment Outcome; Vitamin B 12

2008
Phase II, double-blinded, randomized study of enzastaurin plus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Double-Blind Method; Female; Folic Acid; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pemetrexed; Prognosis; Salvage Therapy; Survival Rate; Vitamin B 12

2010
Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011, Volume: 6, Issue:11

    Topics: Adenocarcinoma; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Prognosis; Tissue Distribution; Vitamin B 12; Vitamin B Complex

2011
Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
    British journal of cancer, 2007, Oct-22, Volume: 97, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Deoxyuridine; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Lung Neoplasms; Male; Methylmalonic Acid; Middle Aged; Pemetrexed; Thymidine; Thymidylate Synthase; Vinblastine; Vinorelbine; Vitamin B 12

2007

Other Studies

39 other study(ies) available for folic acid and Carcinoma, Non-Small Cell Lung

ArticleYear
Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands.
    Scientific reports, 2022, 05-20, Volume: 12, Issue:1

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Count; Cell Line, Tumor; Cell Separation; Folic Acid; Humans; Ligands; Lung Neoplasms; Mice; Molecular Weight; Neoplastic Cells, Circulating

2022
Folic acid-mediated MSNs@Ag@Geb multifunctional nanocomposite heterogeneous platform for combined therapy of non-small cell lung cancer.
    Colloids and surfaces. B, Biointerfaces, 2022, Volume: 217

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Doxorubicin; Folic Acid; Gefitinib; Humans; Lung Neoplasms; Manganese Compounds; Metal Nanoparticles; Nanocomposites; Nanoparticles; Oxides; Silicon Dioxide; Silver

2022
Therapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma.
    Drug delivery, 2022, Volume: 29, Issue:1

    Topics: Adenocarcinoma of Lung; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Folic Acid; Humans; Hydroxamic Acids; Lung Neoplasms; Mice; Nanoparticles; Serum Albumin, Human

2022
Intravenous route for folate supplementation in a patient with celiac disease treated by pemetrexed-based chemotherapy for non-small-cell lung cancer.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2023, Volume: 29, Issue:3

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Celiac Disease; Dietary Supplements; Folic Acid; Humans; Injections, Intravenous; Levoleucovorin; Lung Neoplasms; Pemetrexed

2023
Fighting Non-Small Lung Cancer Cells Using Optimal Functionalization of Targeted Carbon Quantum Dots Derived from Natural Sources Might Provide Potential Therapeutic and Cancer Bio Image Strategies.
    International journal of molecular sciences, 2022, Oct-31, Volume: 23, Issue:21

    Topics: Carbon; Carcinoma, Non-Small-Cell Lung; Folic Acid; Humans; Lung Neoplasms; Microscopy, Fluorescence; Quantum Dots

2022
Probing Folate-Responsive and Stage-Sensitive Metabolomics and Transcriptional Co-Expression Network Markers to Predict Prognosis of Non-Small Cell Lung Cancer Patients.
    Nutrients, 2022, Dec-20, Volume: 15, Issue:1

    Topics: Amino Acid Transport System ASC; Carcinoma, Non-Small-Cell Lung; Folic Acid; Glutamine; Humans; Lung Neoplasms; Metabolomics; Minor Histocompatibility Antigens; Prognosis; Tandem Mass Spectrometry

2022
Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide polymorphisms: a prospective observational study.
    BMC cancer, 2023, Aug-26, Volume: 23, Issue:1

    Topics: Carcinoma, Non-Small-Cell Lung; Folic Acid; Humans; Lung Neoplasms; Mesothelioma, Malignant; Pemetrexed; Polymorphism, Single Nucleotide

2023
A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma.
    PloS one, 2019, Volume: 14, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Carcinoma, Non-Small-Cell Lung; Depression; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lung Neoplasms; Male; Mesothelioma; Mesothelioma, Malignant; Middle Aged; Pemetrexed; Prospective Studies; Treatment Outcome; Vitamin B 12; Vitamins

2019
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Drug Liberation; Drug Synergism; Female; Flavonoids; Folic Acid; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Multidrug Resistance-Associated Proteins; Nanoparticles; Poly (ADP-Ribose) Polymerase-1; Rats; RNA, Small Interfering

2020
[Preliminary Study on Detection of Circulating Tumor Cells in Lung Cancer by EGFR/Vimentin/Folic Acid Magnetic Sphere].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2020, May-20, Volume: 23, Issue:5

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Folic Acid; Humans; Immunomagnetic Separation; Magnetic Phenomena; Male; Middle Aged; Neoplastic Cells, Circulating; Vimentin

2020
Fabrication and in vivo evaluation of ligand appended paclitaxel and artemether loaded lipid nanoparticulate systems for the treatment of NSCLC: A nanoparticle assisted combination oncotherapy.
    International journal of pharmaceutics, 2020, Jun-15, Volume: 583

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Artemether; Biological Availability; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Carriers; Drug Compounding; Drug Liberation; Drug Stability; Folic Acid; Humans; Lipids; Lung Neoplasms; Male; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Polyethylene Glycols; Rats, Sprague-Dawley; Tumor Burden; Xenograft Model Antitumor Assays

2020
Diagnostic and therapeutic evaluation of folate-targeted paclitaxel and vinorelbine encapsulating theranostic liposomes for non-small cell lung cancer.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2021, Jan-01, Volume: 156

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Folic Acid; Liposomes; Lung Neoplasms; Mice; Mice, Inbred C57BL; Paclitaxel; Precision Medicine; Tissue Distribution; Vinorelbine

2021
Disruption of Cytosolic Folate Integrity Aggravates Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Modulates Metastatic Properties in Non-Small-Cell Lung Cancer Cells.
    International journal of molecular sciences, 2021, Aug-17, Volume: 22, Issue:16

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cytoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Tumor Cells, Cultured

2021
FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer.
    Science translational medicine, 2017, Aug-02, Volume: 9, Issue:401

    Topics: A549 Cells; Animals; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Gene Targeting; Gene Transfer Techniques; Humans; Immunocompetence; Ligands; Lung Neoplasms; Mice; MicroRNAs; Proto-Oncogene Proteins p21(ras); Xenograft Model Antitumor Assays

2017
Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer patients.
    The pharmacogenomics journal, 2019, Volume: 19, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; DNA Repair; DNA-Binding Proteins; Endonucleases; Female; Folic Acid; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Platinum; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins c-mdm2; Reduced Folate Carrier Protein; Survival Analysis; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein

2019
Effect of folic acid and vitamin B12 on pemetrexed antifolate chemotherapy in nutrient lung cancer cells.
    BioMed research international, 2013, Volume: 2013

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dietary Supplements; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Folic Acid Antagonists; G1 Phase; Glutamates; Guanine; Humans; Lung Neoplasms; Neoplasm Proteins; Pemetrexed; Protein Stability; Serum; Treatment Outcome; Vitamin B 12

2013
Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico.
    American journal of respiratory and critical care medicine, 2013, Nov-01, Volume: 188, Issue:9

    Topics: Aged; American Indian or Alaska Native; Carcinoma, Non-Small-Cell Lung; Cohort Studies; Diet; DNA Methylation; Female; Folic Acid; Hispanic or Latino; Humans; Longitudinal Studies; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; New Mexico; Promoter Regions, Genetic; Risk Factors; Smoking; Sputum

2013
Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.
    Chemical communications (Cambridge, England), 2014, May-25, Volume: 50, Issue:40

    Topics: Benzene Derivatives; Boronic Acids; Carcinoma, Non-Small-Cell Lung; Endocytosis; Fluorescent Dyes; Folate Receptor 1; Folic Acid; Humans; Lung Neoplasms; Molecular Structure; Muramidase; Tumor Cells, Cultured

2014
KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:6

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Xenograft Model Antitumor Assays

2014
Association of Graded Folic Acid Supplementation and Total Plasma Homocysteine Levels With Hematological Toxicity During First-line Treatment of Nonsquamous NSCLC Patients With Pemetrexed-based Chemotherapy.
    American journal of clinical oncology, 2017, Volume: 40, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Retrospective Studies

2017
Plasma homocysteine levels and hematological toxicity in NSCLC patients after the first cycle of pemetrexed under folate supplementation.
    Anti-cancer drugs, 2015, Volume: 26, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Blood Platelets; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Leukocytes; Lung Neoplasms; Male; Middle Aged; Pemetrexed

2015
[Safety of pemetrexed according to the duration of vitamin B12 and folic acid supplementation prior to the first dose of pemetrexed].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2015, Volume: 42, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Diarrhea; Dietary Supplements; Drug Combinations; Exanthema; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Pemetrexed; Retrospective Studies; Vitamin B 12

2015
Total Plasma Homocysteine Level Assessment and Timing of Folate/B12 Supplementation Prior to Initiation of Pemetrexed-Based Chemotherapy for Nonsquamous Non-Small Cell Lung Cancer Patients: An Irrelevant Investigation, an Unnecessary Delay, or Both?
    The oncologist, 2015, Volume: 20, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Humans; Lung Neoplasms; Male; Vitamin B 12

2015
In Reply.
    The oncologist, 2015, Volume: 20, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Humans; Lung Neoplasms; Male; Vitamin B 12

2015
Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer.
    Cell death & disease, 2015, Jul-16, Volume: 6

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Signal Transduction

2015
Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer.
    Oncotarget, 2015, Dec-08, Volume: 6, Issue:39

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Delivery Systems; Folic Acid; Humans; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Paclitaxel; Polyesters; Polyethylene Glycols; Tissue Distribution; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2015
Hemocompatibility of folic-acid-conjugated amphiphilic PEG-PLGA copolymer nanoparticles for co-delivery of cisplatin and paclitaxel: treatment effects for non-small-cell lung cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood; Blood Coagulation; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line; Cisplatin; Complement Activation; Drug Carriers; Drug Compounding; Folic Acid; Hemolysis; Humans; Leukocyte Count; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Paclitaxel; Polyesters; Polyethylene Glycols; Rabbits; Xenograft Model Antitumor Assays

2016
Resveratrol-loaded folic acid-grafted dextran stearate submicron particles exhibits enhanced antitumor efficacy in non-small cell lung cancers.
    Materials science & engineering. C, Materials for biological applications, 2017, Mar-01, Volume: 72

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Dextrans; Drug Liberation; Folic Acid; Humans; Lung Neoplasms; Mitochondria; Particle Size; Resveratrol; Stilbenes; Tumor Suppressor Protein p53

2017
Combination Therapy of NSCLC Using Hsp90 Inhibitor and Doxorubicin Carrying Functional Nanoceria.
    Molecular pharmaceutics, 2017, 03-06, Volume: 14, Issue:3

    Topics: A549 Cells; Acrylic Resins; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cerium; Combined Modality Therapy; Doxorubicin; Drug Carriers; Folic Acid; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Nanoparticles; Rats; Reactive Oxygen Species; Triazoles

2017
Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer.
    BMC cancer, 2008, Jul-31, Volume: 8

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dexamethasone; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pemetrexed; Vitamin B 12

2008
Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels.
    Cancer science, 2009, Volume: 100, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Cadherins; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Core Binding Factor Alpha 3 Subunit; DNA Methylation; Female; Folic Acid; Humans; Immunohistochemistry; Long Interspersed Nucleotide Elements; Lung Neoplasms; Male; Middle Aged

2009
Toxic epidermal necrolysis related to pemetrexed and carboplatin with vitamin B12 and folic acid supplementation for advanced non-small cell lung cancer.
    Onkologie, 2009, Volume: 32, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Stevens-Johnson Syndrome; Vitamin B 12

2009
Pemetrexed for previously treated patients with non-small cell lung cancer and differences in efficacy according to thymidylate synthase expression.
    Chemotherapy, 2012, Volume: 58, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leukopenia; Lung Neoplasms; Male; Middle Aged; Nausea; Neutropenia; Pemetrexed; Salvage Therapy; Thrombocytopenia; Thymidylate Synthase; Treatment Outcome

2012
Pemetrexed: a new cytotoxic agent in the development for first-line non-small-cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2005, Volume: 50 Suppl 1

    Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Dietary Supplements; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Vitamin B 12

2005
Prognostic significance of folate metabolism polymorphisms for lung cancer.
    British journal of cancer, 2007, Jul-16, Volume: 97, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Enzymes; Female; Folic Acid; Genotype; Humans; Lung Neoplasms; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Prognosis

2007
Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability.
    The oncologist, 2007, Volume: 12, Issue:7

    Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colorectal Neoplasms; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; In Vitro Techniques; Lung Neoplasms; Mesothelioma; Pemetrexed; Tetrahydrofolates

2007
A cross-sectional study of vitamin intake in postoperative non-small cell lung cancer patients.
    Journal of surgical oncology, 1998, Volume: 68, Issue:4

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cross-Sectional Studies; Dietary Supplements; Disease-Free Survival; Erythrocytes; Female; Folic Acid; Humans; Lung Neoplasms; Male; Middle Aged; Pneumonectomy; Postoperative Care; Vitamin A

1998
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
    International journal of cancer, 2000, Sep-15, Volume: 87, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Colonic Neoplasms; Fluorouracil; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leucovorin; Lung Neoplasms; Membrane Proteins; Membrane Transport Proteins; Mice; Multienzyme Complexes; Neoplasms; Peptide Synthases; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured

2000
Folate status among patients with non-small cell lung cancer: a case-control study.
    Journal of surgical oncology, 2001, Volume: 77, Issue:4

    Topics: Aged; Alcohol Drinking; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Diet; Female; Folic Acid; Homocystine; Humans; Lung Neoplasms; Male; Postoperative Period; Risk Factors; Smoking

2001