folic acid has been researched along with Carcinoma, Hepatocellular in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (16.87) | 18.7374 |
| 1990's | 3 (3.61) | 18.2507 |
| 2000's | 8 (9.64) | 29.6817 |
| 2010's | 38 (45.78) | 24.3611 |
| 2020's | 20 (24.10) | 2.80 |
| Authors | Studies |
|---|---|
| Hummel-Eisenbeiss, J; Jedlitschky, G; Keppler, D; Nies, AT; Rius, M | 1 |
| Gao, Y; Ge, S; Jiang, X; Liu, X; Liu, Y; Shen, W; Tian, Y; Wu, C; Wu, Q; Yu, Q | 1 |
| Bertino, G; Bonfiglio, C; Catania, VE; Drago, F; Madeddu, R; Malaguarnera, G; Malaguarnera, M | 1 |
| Aizenshtein, E; Besser, E; Feldman, A; Fokra, M; Hallo, E; Mukha, D; Nevo-Dinur, K; Sarvin, B; Sarvin, N; Schug, ZT; Shlomi, T | 1 |
| Hu, F; Li, Y; Ma, M; Meng, T; Shang, X; Shi, K; Tian, Y; Yuan, H | 1 |
| Fang, AP; He, TT; Liu, XZ; Liu, ZY; Luo, Y; Wusiman, M; Xiao, HW; Yishake, D; Zhu, HL | 1 |
| Ali, T; Kaur, J; Sharma, R | 2 |
| Ning, S; Wang, M; Xia, X; Xu, Y; Yang, Z; Zhou, L | 1 |
| Goyal, H; Kaur, J; Lamba, D; Sharma, R | 1 |
| Chen, X; Guo, B; Kalvakolanu, DV; Liu, X; Liu, Y; Sun, J; Wang, X; Xu, L; Zhang, L | 1 |
| Guo, J; Han, S; Li, Y; Li, YN; O'Driscoll, CM; Shi, X; Shi, Y; Sun, D; Wang, L; Yang, L; Zou, Y | 1 |
| Chen, S; Chen, X; Ding, L; Gao, Y; He, K; Jin, L; Jun, Y; Luo, C; Ma, J; Sun, S; Sun, X; Tang, Z; Tao, M; Wang, QL; Yao, M; Zhang, L; Zhang, M | 1 |
| Antwi, SO; Campbell, PT; Liao, LM; McGlynn, KA; Norez, DA; Patel, T; Petrick, JL; Roberts, LR; Stevens, VL | 1 |
| He, DX; Huang, C; Huang, W; Liu, Y; Long, J; Tan, XW; Tang, S; Wei, H; Xiang, Y; Yu, CY; Zhou, Y | 1 |
| Feng, Y; Liu, M; Tu, J; Wu, J; Zhang, J | 1 |
| Buskaran, K; Fakurazi, S; Hussein, MZ; Mohd Moklas, MA | 1 |
| Bertino, G; Borzì, AM; Catania, VE; Drago, F; Latteri, S; Madeddu, R; Malaguarnera, G; Malaguarnera, M | 1 |
| Li, D; Liu, S; Shen, L; Zhang, QY; Zhu, H; Zhu, J | 1 |
| Ali, T; Das, A; Duseja, A; Kaur, J; Negi, I; Sharma, R | 1 |
| Hejazi, SH; Maghsoudinia, F; Mehradnia, F; Mehrgardi, MA; Samani, RK; Sobhani, T; Tavakoli, MB | 1 |
| Chan, CY; Chiu, DK; Lai, RK; Lan Li, L; Law, CT; Lee, D; Ng, IO; Tsang, FH; Tse, AP; Wei, LL; Wong, CC; Wong, CM; Xu, IM | 1 |
| Gamble, MV; Goyal, A; Gurvich, I; Manji, GA; Safyan, RA; Santella, RM; Shen, J; Siegel, AB; Strauss, JA; Wang, Q; Wu, HC; Yeh, CC | 1 |
| Chen, Z; Fan, F; Hu, C; Kong, D; Leng, X; Qin, Y; Sun, H; Wang, C; Wang, H; Wu, S; Zhang, L; Zhu, D | 1 |
| Chen, J; Duan, S; He, J; Hu, Z; Lu, X; Su, J; Yang, N; Zhang, Z; Zhao, Y; Zhou, S | 1 |
| Chen, CF; Chern, CL; Ho, CT; Lai, KG; Liu, JJ; Liu, TZ | 1 |
| Carallo, S; Cascione, M; Di Corato, R; Dini, L; Fabregat, I; Hanafy, NAN; Leporatti, S; Malfettone, A; Nobile, C; Quarta, A; Rinaldi, R; Soukupova, J; Tasco, V | 1 |
| Chang, Z; Dong, WF; Li, M; Lu, M; Shao, D; Wang, Y; Wang, Z; Xu, Q; Yang, D; Yue, J | 1 |
| Anwar, DM; Bekhit, AA; Elkhodairy, KA; Elzoghby, AO; Helmy, MW; Kamal, MK; Khattab, SN | 1 |
| Cui, F; Kawashima, Y; Li, L; Liang, N; Sun, S; Wang, D; Yan, P | 1 |
| Cao, P; Chen, Y; Cui, J; Li, Y; Li, Z; Liu, W; Shang, Y; Yin, X | 1 |
| Chen, MS; Chen, PY; Fang, AP; Liao, GC; Ling, WH; Liu, ZY; Long, JA; Luo, Y; Wang, XY; Xu, XJ; Xu, YJ; Zhang, DM; Zhang, YJ; Zhong, RH; Zhou, ZG; Zhu, HL | 1 |
| Chen, H; Li, W; Tao, R; Wang, C; Ye, J; Zhang, C; Zhou, H | 1 |
| Bertino, G; Borzì, AM; Catania, VE; Drago, F; La Greca, G; Latteri, S; Malaguarnera, G; Malaguarnera, M | 1 |
| Das, D; Drazba, JA; Fayazzadeh, E; Koirala, N; McClain, A; McLennan, G; Puskas, JE; Sen, S | 1 |
| Gong, F; Ma, J; Shen, J; Zhang, F; Zhang, L; Zhang, P | 1 |
| Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC | 1 |
| Chen, CH; Cheng, CP; Huang, CY; Kuo, CS; Kuo, HT; Lu, CL; Syu Huang, RF; Yang, FL | 1 |
| Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V | 1 |
| Fan, Y; Wu, Y; Zhang, L | 1 |
| Bánfalvi, G; Bodnár, M; Borbély, J; Emri, M; Hajdu, I; Kollár, J; Márián, T; Sikula, J; Trencsényi, G; Vámosi, G | 1 |
| Gong, X; Jiang, S; Zhao, X; Zu, Y | 1 |
| Azoulay, D; Calderaro, J; Zafrani, ES | 1 |
| Chen, GG; Ho, RL; Hu, BG; Lai, PB; Leung, KK; Lin, MC; Liu, LP; Ye, CG | 1 |
| Jing, X; Liu, S; Sun, Y; Tong, T; Wang, R; Wu, W; Zhang, F; Zhang, H; Zhang, Y | 1 |
| Hackett, MJ; Hui, KM; Hyeon, T; Ling, D; Na, K; Park, W; Song, C; Xia, H | 1 |
| Lei, QY; Li, JT; Ren, F; Wang, LY; Xu, YY; Yang, HB; Zhang, M; Zhang, Y; Zhao, XN; Zou, SW | 1 |
| He, J; Lai, C; Lu, X; Luo, G; Peng, Y; Xie, X; Xie, Y; Yu, X; Zhao, Y; Zhou, N; Zhou, S; Zhuo, H | 1 |
| Chang, JB; Ho, CT; Liu, JJ; Liu, TZ; Shang, HS | 1 |
| Gao, B; He, KW; Shen, L; Xiao, WH | 1 |
| Cheng, SB; Huang, YC; Lai, CY; Lin, PT; Liu, HT | 1 |
| Gao, JQ; Han, M; Hu, Y; Liu, L; Liu, MC; Shuai, WP; Wang, XR | 1 |
| Duan, S; Fang, Y; He, J; Huang, X; Lai, C; Lu, X; Luo, G; Song, M; Xie, Y; Yi, P; Yu, X; Zhang, Z; Zhao, J; Zhao, Y; Zhou, N; Zhou, S | 1 |
| Choi, JS; Cui, LH; Jiang, MH; Piao, JM; Quan, ZY; Shin, MH; Zhang, TT | 1 |
| Ge, S; Han, B; Hu, Y; Jiang, J; Li, K; Liu, Y; Wang, Y; Zhang, S | 1 |
| Li, C; Liang, ZQ; Liu, YX; Ni, J; Wang, H; Wang, X | 1 |
| Kuo, CS; Lin, CY; Lu, CL; Syu Huang, RF; Wu, MY | 1 |
| Cabelof, DC; Chowdhury, ME; Heydari, AR; Papakonstantinou, EV; Patel, HV; Pilling, AB; Prychitko, TM; Unnikrishnan, A; Ventrella-Lucente, LF | 1 |
| Cheng, D; Hong, G; Niu, C; Sun, Q; Zhou, J | 1 |
| Freedman, ND; Graubard, BI; Hollenbeck, AR; McGlynn, KA; Park, Y; Persson, EC; Schwartz, LM; Trabert, B | 1 |
| Goldman, ID; Hanscom, M; Zhao, R | 1 |
| Chen, G; Evans, AA; Katki, HA; Lin, WY; London, WT; McGlynn, KA; O'Broin, S; Sakoda, LC; Shen, FM; Welzel, TM | 1 |
| Huang, RF; Kuo, CS; Lin, CY; Lu, CL; Wu, MY | 1 |
| Asmar, L; Cohn, AL; Deur, C; Hood, K; Ilegbodu, D; Khan, MM; Mamus, S; Myers, JW; Nicol, S | 1 |
| Hong, G; Liang, B; Shen, J; Shuai, X; Yang, X; Yuan, R | 1 |
| Chen, YH; Cheng, JT; Chern, CL; Huang, RF; Liu, TZ | 1 |
| Poirier, LA | 2 |
| Rogers, AE | 1 |
| Roth, JJ; Roth, JS | 1 |
| Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O | 1 |
| Bunni, M; Freisheim, JH; Galivan, J; Priest, DG; Rhee, M; Whiteley, JM | 1 |
| Balinska, M; Bunni, M; Galivan, J; Maley, F; Maley, GF; Priest, DG; Rhee, MS | 1 |
| Buamah, PK; Cornell, C; Harris, AL; James, OF; Skillen, AW | 1 |
| Buamah, PK; Harris, AL; James, OF; Skillen, AW | 1 |
| Bassendine, MF; Curtin, NJ; Harris, AL; James, OF; Loose, H | 1 |
| Duch, D; Ferone, R; Galivan, J; Gaumont, Y; Jones, C; Kisliuk, RL; Maley, F; Nair, MG; Patil, SD | 1 |
| Bassendine, MF; Curtin, NJ; Harris, AL; James, OF | 1 |
| Bennett, M; Buamah, PK; James, OF; Lendrum, R; McArdle, P | 1 |
| Bukin, IuV; Raushenbakh, MO; Sergeev, AV | 1 |
| Maley, F; Maley, GF | 1 |
| Gottlieb, LS; Hegsted, DM; Iseri, OA; Vitale, JJ | 1 |
| Brown, GF; Schmid, FA; Schmid, MM; Sugiura, K | 1 |
1 trial(s) available for folic acid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Dexamethasone; Disease Progression; Female; Folic Acid; Glutamates; Guanine; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pemetrexed; Survival Rate; Treatment Outcome; Vitamin B 12 | 2008 |
82 other study(ies) available for folic acid and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Polarity; Cholagogues and Choleretics; Cricetinae; Fibroblasts; Gene Expression; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Rats; Taurocholic Acid; Transfection; Transport Vesicles; Tritium | 2003 |
Folate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomimetics; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Membrane; Cell Survival; Drug Carriers; Drug Liberation; Female; Folic Acid; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Paclitaxel; Particle Size; Polyethylene Glycols; Random Allocation; Surface Properties; Tumor Burden; Xenograft Model Antitumor Assays | 2022 |
Serum Folate deficiency in HCV related Hepatocellular Carcinoma.
Topics: Carcinoma, Hepatocellular; Folic Acid; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Homocysteine; Humans; Liver Cirrhosis; Liver Neoplasms; RNA | 2022 |
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth.
Topics: Carcinoma, Hepatocellular; Folic Acid; Glycine; Glycine Dehydrogenase (Decarboxylating); Humans; Lipoylation; Liver Neoplasms; Mitochondrial Proteins; Nucleotides | 2022 |
A Hypoxia-Sensitive Drug Delivery System Constructed by Nitroimidazole and its Application in the Treatment of Hepatocellular Carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Hypoxia; Liver Neoplasms; Micelles; Nitroimidazoles; Polyethylene Glycols; Tumor Microenvironment | 2022 |
Dietary intake of one-carbon metabolism-related nutrients and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort.
Topics: Carbon; Carcinoma, Hepatocellular; Cohort Studies; Diet; Eating; Folic Acid; Humans; Liver Neoplasms; Methionine; Nutrients; Prospective Studies; Risk Factors | 2022 |
Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells.
Topics: Carcinogenesis; Carcinoma, Hepatocellular; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Necrosis; Sepharose | 2022 |
Development of Glycyrrhetinic Acid and Folate Modified Cantharidin Loaded Solid Lipid Nanoparticles for Targeting Hepatocellular Carcinoma.
Topics: Antineoplastic Agents; Cantharidin; Carcinoma, Hepatocellular; Drug Carriers; Emulsions; Folic Acid; Glycyrrhetinic Acid; Humans; Liver Neoplasms; Nanoparticles; Particle Size | 2022 |
Folic acid depletion along with inhibition of the PERK arm of endoplasmic reticulum stress pathway promotes a less aggressive phenotype of hepatocellular carcinoma cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; eIF-2 Kinase; Endoplasmic Reticulum Stress; Folic Acid; Humans; Liver Neoplasms; Phenotype; Unfolded Protein Response | 2023 |
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Folic Acid; Genetic Therapy; Liver Neoplasms; Mice; Polyethylene Glycols; Polyethyleneimine; RNA, Small Interfering; STAT3 Transcription Factor | 2023 |
Delivery of melarsoprol using folate-targeted PEGylated cyclodextrin-based nanoparticles for hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclodextrins; Folic Acid; Humans; Liver Neoplasms; Melarsoprol; Mice; Nanoparticles; Polyethylene Glycols | 2023 |
Nanovector Assembled from Natural Egg Yolk Lipids for Tumor-Targeted Delivery of Therapeutics.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Egg Yolk; Female; Folic Acid; Humans; Lipids; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared; Tissue Distribution; Xenograft Model Antitumor Assays | 2020 |
One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: A prospective cohort study.
Topics: Carbon; Carcinoma, Hepatocellular; Diet; Dietary Supplements; Eating; Female; Folic Acid; Humans; Liver Neoplasms; Male; Methionine; Micronutrients; Middle Aged; Nutritional Status; Prospective Studies; Riboflavin; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2020 |
Facile Fabrication of Nanoparticles with Dual-Targeting Ligands for Precise Hepatocellular Carcinoma Therapy
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Chitosan; Fluorouracil; Folic Acid; Hepatocytes; Human Umbilical Vein Endothelial Cells; Humans; Ligands; Liver Neoplasms; Nanoparticles; Precision Medicine; Prodrugs; Solubility | 2020 |
Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Folic Acid; Lipid Bilayers; Liver; Liver Neoplasms; Mice; Nanoparticles; Nitrophenols; Piperazines; Silicon Dioxide; Sulfonamides | 2020 |
Morphological Changes and Cellular Uptake of Functionalized Graphene Oxide Loaded with Protocatechuic Acid and Folic Acid in Hepatocellular Carcinoma Cancer Cell.
Topics: Anticarcinogenic Agents; Biological Transport; Carcinoma, Hepatocellular; Drug Liberation; Folic Acid; Graphite; Hep G2 Cells; Humans; Hydroxybenzoates; Liver Neoplasms; Nanocomposites; Nanoparticles; Polyethylene Glycols; Vitamins | 2020 |
Tumor suppressor genes are differentially regulated with dietary folate modulations in a rat model of hepatocellular carcinoma.
Topics: Animal Feed; Animals; Apoptosis; Carcinoma, Hepatocellular; Core Binding Factor Alpha 3 Subunit; Diet; Disease Models, Animal; DNA Fragmentation; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Liver Neoplasms; Male; Rats; Rats, Wistar; Suppressor of Cytokine Signaling 1 Protein; Tumor Suppressor Proteins | 2021 |
Folate levels in hepatocellular carcinoma patients with portal vein thrombosis.
Topics: Carcinoma, Hepatocellular; Female; Folic Acid; Humans; Liver Neoplasms; Male; Portal Vein; Retrospective Studies; Venous Thrombosis | 2020 |
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Benzophenanthridines; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Folic Acid; Humans; Liver Neoplasms; Micelles; Nanoparticles; Vitamin E | 2021 |
Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Rats; Rats, Wistar | 2021 |
Folic acid-functionalized gadolinium-loaded phase transition nanodroplets for dual-modal ultrasound/magnetic resonance imaging of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Contrast Media; Folic Acid; Gadolinium; Liver Neoplasms; Magnetic Resonance Imaging; Mice; Nanoparticles | 2021 |
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.
Topics: Aminohydrolases; Carcinoma, Hepatocellular; Folic Acid; Formate-Tetrahydrofolate Ligase; Hep G2 Cells; Humans; Liver Neoplasms; Methylenetetrahydrofolate Dehydrogenase (NADP); Multienzyme Complexes; Neoplasm Proteins; NF-E2-Related Factor 2 | 2017 |
Global Level of Plasma DNA Methylation is Associated with Overall Survival in Patients with Hepatocellular Carcinoma.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Methylation; Female; Folic Acid; Follow-Up Studies; Genome, Human; Humans; Liver Neoplasms; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Prospective Studies; Survival Rate | 2017 |
Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Folic Acid; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Xenograft Model Antitumor Assays | 2017 |
Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chemokine CXCL10; Chitosan; Dendritic Cells; Disease Models, Animal; Drug Carriers; Folic Acid; Heterografts; Mice; Mice, Inbred C57BL; Nanoparticles; Treatment Outcome; Vaccines, DNA | 2017 |
Novel roles of folic acid as redox regulator: Modulation of reactive oxygen species sinker protein expression and maintenance of mitochondrial redox homeostasis on hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Folic Acid; Gene Expression Regulation, Neoplastic; Glutathione; Heat-Shock Proteins; Hep G2 Cells; Homeostasis; Humans; Inhibitor of Apoptosis Proteins; Isocitrate Dehydrogenase; Liver Neoplasms; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Survivin | 2017 |
Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cattle; Colloids; Drug Carriers; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Liver Neoplasms; Microscopy, Atomic Force; Microscopy, Fluorescence; Peptides; Polymers; RNA, Small Interfering; Serum Albumin, Bovine; Spectroscopy, Fourier Transform Infrared; Transforming Growth Factor beta | 2017 |
Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemoradiotherapy; Doxorubicin; Drug Screening Assays, Antitumor; Folic Acid; Gold; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Metal Nanoparticles; Mice; Neoplasms, Experimental; Particle Size; Porosity; Silicon Dioxide; Surface Properties; Tomography, X-Ray Computed | 2017 |
Lactobionic/Folate Dual-Targeted Amphiphilic Maltodextrin-Based Micelles for Targeted Codelivery of Sulfasalazine and Resveratrol to Hepatocellular Carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Disaccharides; Drug Delivery Systems; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Micelles; Polysaccharides; Resveratrol; Sulfasalazine; Xenograft Model Antitumor Assays | 2018 |
Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Deoxycholic Acid; Drug Carriers; Female; Folic Acid; Humans; Injections, Intravenous; Liver Neoplasms; MCF-7 Cells; Mice; Micelles; Neoplasm Transplantation; Paclitaxel; Particle Size; Xenograft Model Antitumor Assays | 2018 |
Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Death; Cell Survival; Embryo, Nonmammalian; Fluorescence; Folic Acid; Gadolinium; Hep G2 Cells; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Metal-Organic Frameworks; Nanoparticles; Photochemotherapy; Time-Lapse Imaging; Zebrafish | 2019 |
Serum folate concentrations at diagnosis are associated with hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort study.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; China; Female; Folic Acid; Humans; Liver Neoplasms; Male; Middle Aged; Proportional Hazards Models; Prospective Studies | 2019 |
Characterization, Cytotoxicity and Genotoxicity of Graphene Oxide and Folate Coupled Chitosan Nanocomposites Loading Polyprenol and Fullerene Based Nanoemulsion Against MHCC97H Cells.
Topics: Carcinoma, Hepatocellular; Chitosan; Folic Acid; Fullerenes; Graphite; Humans; Liver Neoplasms; Nanocomposites; Oxides | 2019 |
Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis.
Topics: Adult; Aged; Biomarkers, Tumor; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Cholesterol, LDL; Female; Folic Acid; Homocysteine; Humans; Liver Neoplasms; Male; Middle Aged; Portal Vein; Prognosis; Vitamin B 12; Vitamin B 6 | 2019 |
Folic acid conjugated polymeric drug delivery vehicle for targeted cancer detection in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Folic Acid; Humans; Liver Neoplasms, Experimental; Optical Imaging; Rats; Rats, Sprague-Dawley; U937 Cells | 2019 |
Targeted therapy for human hepatic carcinoma cells using folate-functionalized polymeric micelles loaded with superparamagnetic iron oxide and sorafenib in vitro.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Drug Carriers; Drug Delivery Systems; Ferrocyanides; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Magnetite Nanoparticles; Micelles; Microscopy, Electron, Transmission; Niacinamide; Phenylurea Compounds; Sorafenib | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Carcinoma, Hepatocellular; Deoxyguanosine; DNA Damage; Erythrocytes; Female; Folic Acid; Gene Frequency; Genotype; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Oxidative Stress; Polymorphism, Genetic; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Risk Factors; Tumor Suppressor Protein p53 | 2014 |
Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Humans; Liver Neoplasms; Male; Neoplasm Proteins; Neovascularization, Pathologic; Rats; Transcriptome; Triglycerides | 2014 |
Inositol based non-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Folic Acid; Genetic Vectors; HeLa Cells; Humans; Inositol; Liver Neoplasms; Magnetic Resonance Spectroscopy; Mice; Microscopy, Electron, Transmission; NIH 3T3 Cells; Spectroscopy, Fourier Transform Infrared | 2014 |
Tumor-specific localization of self-assembled nanoparticle PET/MR modalities.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Chitosan; Contrast Media; Flow Cytometry; Folate Receptors, GPI-Anchored; Folic Acid; Liver Neoplasms; Magnetic Resonance Imaging; Male; Nanoparticles; Polyglutamic Acid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 2014 |
Preparation, characterization, and antitumor activities of folate-decorated docetaxel-loaded human serum albumin nanoparticles.
Topics: Animals; Animals, Outbred Strains; Antineoplastic Agents; Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Docetaxel; Drug Carriers; Drug Compounding; Drug Delivery Systems; Folic Acid; Humans; Liver Neoplasms, Experimental; Mice; Nanoparticles; Particle Size; Random Allocation; Sarcoma; Serum Albumin; Serum Albumin, Human; Solubility; Surface Properties; Taxoids | 2015 |
Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Colorectal Neoplasms; Drug Therapy; Fluorouracil; Folic Acid; Hepatectomy; Humans; Hyperplasia; Liver; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Vascular Diseases | 2014 |
Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma.
Topics: alpha-Fetoproteins; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatocellular; Cellulose; Cyclodextrins; Folic Acid; Genetic Therapy; Genetic Vectors; Hep G2 Cells; Humans; Liver Neoplasms; Nanoparticles; Polyethyleneimine; Promoter Regions, Genetic; Treatment Outcome; Tumor Cells, Cultured | 2014 |
Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Emulsions; Female; Folic Acid; Lung Neoplasms; Mice; Mice, Inbred BALB C; Micelles; Molecular Targeted Therapy; Paclitaxel; Polymers; Treatment Outcome | 2014 |
pH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry, Pharmaceutical; Diterpenes; Down-Regulation; Drug Liberation; Epoxy Compounds; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Mice; Molecular Targeted Therapy; Nanostructures; Phenanthrenes; Survival Analysis; Xenograft Model Antitumor Assays | 2014 |
Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer.
Topics: Acetylation; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; E1A-Associated p300 Protein; Folic Acid; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Histone Deacetylases; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Mice, Nude; Ubiquitination | 2015 |
Anti-tumor immune response of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chitosan; Cricetinae; DNA; Female; Folic Acid; Immunotherapy; Interferon gamma Receptor; Liver Neoplasms; Mice; Mice, Inbred BALB C; Nanocapsules; Particle Size; Receptors, Interferon; Transfection; Treatment Outcome | 2014 |
Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folic Acid; Heat-Shock Proteins; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Oxidation-Reduction; Reactive Oxygen Species; RNA Interference; Signal Transduction; Survivin | 2015 |
GNRs@SiO₂-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cytoplasm; Endocytosis; Folic Acid; Gold; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms; Nanotubes; Neoadjuvant Therapy; Proto-Oncogene Proteins c-bcl-2; Radiotherapy; Silicon Dioxide | 2015 |
Folate and vitamin B-6 status are not associated with homocysteine, oxidative stress and antioxidant capacities in patients with hepatocellular carcinoma.
Topics: Aged; Antioxidants; Carcinoma, Hepatocellular; Female; Folic Acid; Glutathione Peroxidase; Glutathione Transferase; Homocysteine; Humans; Liver Neoplasms; Male; Malondialdehyde; Middle Aged; Nutritional Status; Oxidative Stress; Pyridoxal Phosphate; Superoxide Dismutase; Vitamin B 6 | 2016 |
Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Proliferation; Chromatography, Liquid; Folate Receptor 1; Folic Acid; Half-Life; Humans; In Vitro Techniques; Liposomes; Liver Neoplasms; Male; Mice; Particle Size; Polyethylene Glycols; Tissue Distribution | 2016 |
Folate-Modified Chitosan Nanoparticles Coated Interferon-Inducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes' Responses to Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Chemokine CXCL10; Chitosan; Coated Materials, Biocompatible; Folate Receptors, GPI-Anchored; Folic Acid; Immunotherapy, Adoptive; Mice; Mice, Inbred BALB C; Mice, Nude; Nanocapsules; Survival Rate; T-Lymphocytes, Cytotoxic; Treatment Outcome | 2016 |
Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma.
Topics: Adult; Aged; Biomarkers; Carcinoma, Hepatocellular; Case-Control Studies; Female; Folic Acid; Humans; Immunoassay; Liver Neoplasms; Luminescent Measurements; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Odds Ratio; Risk Factors; Vitamin B 12 | 2016 |
Preparation and Characterization of Novel Perfluorooctyl Bromide Nanoparticle as Ultrasound Contrast Agent via Layer-by-Layer Self-Assembly for Folate-Receptor-Mediated Tumor Imaging.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Contrast Media; Diagnostic Imaging; Drug Stability; Fluorocarbons; Folic Acid; Hemolysis; Humans; Hydrocarbons, Brominated; Liver Neoplasms; Materials Testing; Nanoparticles; Particle Size; Receptors, Cell Surface; Temperature; Ultrasonography | 2016 |
Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Progression; DNA Methylation; Folic Acid; Folic Acid Deficiency; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hepatocytes; Homeostasis; Humans; Liver Neoplasms; Methylenetetrahydrofolate Reductase (NADPH2); MicroRNAs; Poly A; RNA, Messenger | 2017 |
Lymphocytic mitochondrial DNA deletions, biochemical folate status and hepatocellular carcinoma susceptibility in a case-control study.
Topics: Aged; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Case-Control Studies; DNA Primers; DNA Probes; DNA, Mitochondrial; Female; Folic Acid; Gene Amplification; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Lymphocytes; Magnetic Resonance Imaging; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Sequence Deletion; Smoking; Taiwan | 2009 |
Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; CpG Islands; Deoxyguanosine; DNA Damage; DNA Footprinting; DNA Methylation; DNA Polymerase beta; DNA Repair; Electrophoretic Mobility Shift Assay; Epigenomics; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidative Stress; Promoter Regions, Genetic | 2011 |
Folate-functionalized polymeric micelles based on biodegradable PEG-PDLLA as a hepatic carcinoma-targeting delivery system.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Hydrogen-Ion Concentration; Ligands; Liver Neoplasms; Micelles; Polyesters; Polyethylene Glycols; Receptors, Cell Surface | 2011 |
Alcohol consumption, folate intake, hepatocellular carcinoma, and liver disease mortality.
Topics: Aged; Alcohol Drinking; Carcinoma, Hepatocellular; Diet; Female; Folic Acid; Follow-Up Studies; Humans; Incidence; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Risk Factors; United States | 2013 |
The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; RNA, Small Interfering; Transfection | 2005 |
Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort.
Topics: Alanine Transaminase; Carcinoma, Hepatocellular; China; Cohort Studies; DNA, Viral; Erythrocytes; Female; Folic Acid; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Prospective Studies | 2007 |
Relationship between folate status and tumour progression in patients with hepatocellular carcinoma.
Topics: Aged; alpha-Fetoproteins; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chi-Square Distribution; Disease Progression; Female; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Nutritional Status; Odds Ratio; Prospective Studies; Risk | 2008 |
Folate-functionalized polymeric micelle as hepatic carcinoma-targeted, MRI-ultrasensitive delivery system of antitumor drugs.
Topics: Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Contrast Media; Doxorubicin; Drug Carriers; Drug Delivery Systems; Ferric Compounds; Ferrocyanides; Folic Acid; Humans; Indicators and Reagents; Ligands; Liver Neoplasms; Micelles; Microscopy, Electron, Scanning; Models, Biological; Polyesters; Polyethylene Glycols; Polymers; Radiography; Sensitivity and Specificity; Tetrazolium Salts | 2008 |
Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Catalase; Cell Division; DNA Fragmentation; DNA, Neoplasm; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Homocysteine; Humans; Hydrogen Peroxide; Malondialdehyde; Methionine; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Transcription Factors; Tumor Cells, Cultured | 2001 |
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.
Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12 | 1975 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylnitrosamine; Esophageal Neoplasms; Folic Acid; Hemangioendothelioma; Lipotropic Agents; Liver Neoplasms; Male; Methionine; Neoplasms, Experimental; Nicotinic Acids; Nitrosamines; Rats | 1977 |
Thymidylate synthetase activity in the Novikoff hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Cycloheximide; Dactinomycin; Folic Acid; Liver Neoplasms; Male; Methotrexate; Methyltransferases; Neoplasms, Experimental; Puromycin; Rats; Tetrahydrofolates; Thymidylate Synthase | 1976 |
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture.
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Deoxyuridine; Folic Acid; Glycine; Humans; Kinetics; Liver Neoplasms; Methotrexate; Tritium; Tumor Cells, Cultured | 1991 |
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
Topics: Carcinoma, Hepatocellular; Folic Acid; Liver Neoplasms; Pteroylpolyglutamic Acids; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Trimetrexate; Tumor Cells, Cultured | 1990 |
Serial serum AFP heterogeneity changes in patients with hepatocellular carcinoma during chemotherapy.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Concanavalin A; Folic Acid; Humans; Liver Neoplasms; Quinazolines | 1986 |
Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717.
Topics: Adult; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Female; Folic Acid; Follow-Up Studies; Humans; L-Lactate Dehydrogenase; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Quinazolines; Vitamin B 12 | 1987 |
Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor, CB3717. A phase II study.
Topics: Adult; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Drug Evaluation; Female; Folic Acid; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Quinazolines; Remission Induction | 1987 |
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.
Topics: Breast Neoplasms; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Fibroblasts; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Liver Neoplasms; Lymphoma; Molecular Structure; Streptococcus; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thymidine | 1986 |
A pleomorphic hepatocellular carcinoma with biochemical features of fibrolamellar hepatocellular carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Folic Acid; Humans; Liver Neoplasms; Neurotensin; Quinazolines; Vitamin B 12 | 1986 |
[New route of regulating folic acid metabolism in experimental chemotherapy of leukoses and malignant neoplasms].
Topics: Animals; Carcinoma, Hepatocellular; Cycloserine; Female; Folic Acid; Leukemia, Experimental; Liver; Liver Neoplasms; Lymphoma, Non-Hodgkin; Male; Methotrexate; Mice; Neoplasms, Experimental; Pyridoxal Phosphate; Rats; Spleen; Tetrahydrofolate Dehydrogenase; Transferases | 1971 |
The apparent induction of thymidylate synthetase by amethopterin.
Topics: Animals; Aspartic Acid; Benzoates; Carcinoma, Hepatocellular; Enzyme Induction; Folic Acid; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Methotrexate; Methyltransferases; Neoplasms, Experimental; Quinazolines; Rats; Thymine Nucleotides; Uracil Nucleotides | 1971 |
Vitamin B 12 and methionine metabolism in the Buffalo rat liver and Morris 5123 hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Choline Deficiency; Fatty Liver; Folic Acid; Homocystine; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Methylation; Neoplasms, Experimental; Nutrition Disorders; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Effect of compounds on a spectrum of rat tumors.
Topics: Adrenal Gland Neoplasms; Alkylating Agents; Amides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Female; Fibrosarcoma; Folic Acid; Kidney Neoplasms; Liver Neoplasms; Lymphoma, Non-Hodgkin; Neoplasms, Experimental; Ovarian Neoplasms; Purines; Pyrimidines; Quinolines; Rats; Sarcoma; Sarcoma, Yoshida; Steroids | 1972 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic Acid; Folic Acid Deficiency; Formates; Glycine; Guanine; Liver Neoplasms; Male; Methionine; Neoplasms, Experimental; Rats; Serine; Thymidine; Vitamin B 12 | 1973 |