Page last updated: 2024-08-17

folic acid and Acute Lymphoid Leukemia

folic acid has been researched along with Acute Lymphoid Leukemia in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.93)	18.7374
1990's	13 (12.15)	18.2507
2000's	38 (35.51)	29.6817
2010's	49 (45.79)	24.3611
2020's	6 (5.61)	2.80

Authors

Authors	Studies
Blomgren, A; Hansson, K; Heldrup, J; Isaksson, A; Orrling, H; Pronk, CJ; Schliamser, G	1
de Smith, AJ; Kang, AY; Li, S; Metayer, C; Morimoto, L; Nickels, EM; Wiemels, JL	1
Anak, S; Devecioglu, O; Kandemir, I; Karaman, S; Varkal, MA; Yaman, A	1
Gandy, K; Hudson, MM; Jacola, LM; Koscik, TR; Krull, KR; Pui, CH; Sapkota, Y; Scoggins, MA; van der Plas, E	1
de Jonge, R; Fiocco, M; Heil, SG; Oosterom, N; Pieters, R; Smith, DEC; Tissing, WJE; van den Heuvel-Eibrink, MM; van Zelst, BD	1
Bayer, M; Boller, S; Edwards-Hicks, J; Grosschedl, R; Grün, D; Herman, JS; Klein-Geltink, R; Kometani, K; Li, R; Pearce, EL; Ramachandran, H; Ramamoorthy, S	1
Ford, D; Mathers, JC; McKay, JA; Moorman, AV; Potter, C; Relton, CL; Strathdee, G	1
Shao, Y; Shi, J; Tan, B; Zhou, Q	1
Alshamaseen, D; Alsheikh, A; Farhad, R; Kadi, T; Yousef, AM; Zawiah, M	1
Basu, D; Dubashi, B; Jadhav, N; Kayal, S; Kumar, RCS; Madasamy, P; Nandeesha, H; Pattnaik, J; Pillai, US; Vinod, KV	1
Buffler, PA; Chokkalingam, AP; Chun, DS; Metayer, C; Month, SR; Noonan, EJ; Pfeiffer, CM; Taggart, DR; Wiemels, JL; Zhang, M	1
Antal, P; Erdélyi, DJ; Falus, A; Gézsi, A; Hullám, G; Kovács, G; Kutszegi, N; Lautner-Csorba, O; Semsei, ÁF; Szalai, C	1
Dietz, DJ; Kamdar, KY; Lupo, PJ; Scheurer, ME	1
Cao, Y; Lupo, PJ; Nousome, D; Scheurer, ME; Swartz, MD	1
Csordas, K; Eipel, OT; Erdelyi, DJ; Harnos, A; Hegyi, M; Kovacs, GT; Lautner-Csorba, O; Semsei, AF; Szalai, C	1
Bakhshi, S; Gulati, S; Jain, P; Pandey, RM; Seth, R; Toteja, GS	1
Ajrouche, R; Baruchel, A; Bergeron, C; Clavel, J; Ducassou, S; Gandemer, V; Hémon, D; Lutz, P; Michel, G; Nelken, B; Orsi, L; Pasquet, M; Petit, A; Rialland, X; Rudant, J; Saumet, L	1
Agrawal, S; Awasthi, S; Kumar, A; Mahdi, AA; Roy Moulik, N	1
Armstrong, BK; Clavel, J; Dockerty, JD; Ezzat, S; Hung, RJ; Infante-Rivard, C; Kaatsch, P; Kang, AY; Koifman, S; McCauley, K; Metayer, C; Milne, E; Moschovi, M; Petridou, E; Pombo-de-Oliveira, MS; Rashed, WM; Rudant, J; Schüz, J; Selvin, S; Spector, LG; Wesseling, C	1
Kumar, A; Moulik, NR	1
Armstrong, BK; Attia, J; Bailey, HD; Bower, C; Greenop, KR; Marshall, GM; Miller, M; Milne, E	1
de Jonge, R; de Rooij, JD; den Boer, E; den Hoed, MA; Garcia-Orad, A; Gutierrez-Camino, A; Lopez-Lopez, E; Pieters, R; Pluijm, SM; te Winkel, ML; Tissing, W; van den Heuvel-Eibrink, MM	1
Armstrong, BK; Attia, J; Bailey, HD; Bower, C; Dawson, S; de Klerk, NH; Greenop, KR; Haber, M; Jamieson, SE; McCowage, GB; Miller, M; Milne, E; Norris, MD; Scott, RJ; van Bockxmeer, FM	1
Debeljak, M; Dolžan, V; Erčulj, N; Faganel Kotnik, B; Goričar, K; Hovnik, T; Jazbec, J	1
Chen, Y; Shen, Z	1
Dwivedi, P; Hazarika, NC	1
Laxmaiah, A	1
Kumar, A; Mahdi, AA; Moulik, NR; Tandon, S	1
Holman, CD; Jin, J; Liu, P; Xie, X; Zhang, M	1
Fichna, M; Gowin, E; Januszkiewicz-Lewandowska, D; Kałużna, E; Mańkowski, P; Nowak, J; Strauss, E; Świątek-Kościelna, B; Zając-Spychała, O	1
Block, G; Carmichael, SL; Golden, C; Metayer, C; Selvin, S; Singer, AW	1
Jazbec, J; Karas-Kuzelicki, N; Mlinaric-Rascan, I; Smid, A	1
Dahl, G; Metayer, C; Miller, M; Wiemels, J	1
Choumerianou, DM; Kalmanti, M; Karathanasis, NV	1
Becker, A; Bode, U; Jaehde, U; Schüsseler, P; Vezmar, S	1
de Jonge, R; Hooijberg, JH; Jansen, G; Kaspers, GJ; Lindemans, J; Peters, GJ; Pieters, R; Tissing, WJ	1
Beckwith, KA; Cole, PD; Kamen, BA; Roychowdhury, S; Smith, AK; Vijayanathan, V	1
Jeha, S	1
Assaraf, YG; Avivi, I; Stark, M; Wichman, C	1
Cohen, IJ	1
Albertioni, F; Assaraf, YG; Fotoohi, AK; Hashemi, J; Jansen, G; Larsson, C; Moshfegh, A; Peters, GJ	1
Ambrosio, C; Catozzi, L; Cuneo, A; De Mattei, M; Della Porta, M; Friso, S; Gemmati, D; Krampera, M; Ongaro, A; Orioli, E; Serino, ML; Zeri, G	1
Ambrosio, C; Caruso, A; Catozzi, L; De Mattei, M; Della Porta, MG; Di Raimondo, F; Gemmati, D; Masieri, FF; Ongaro, A; Pellati, A; Rigolin, G	1
Hermans, FJ; Kaspers, GJ; Koppen, IJ	1
Allan, JM; Johnston, WT; Lightfoot, TJ; Painter, D; Roman, E; Simpson, J; Skibola, CF; Smith, MT; Taylor, GM	1
Chan, JY; Lu, Y; Lum, DW; Ugrasena, DG; Yeoh, AE	1
de Jonge, R; de Muinck Keizer-Schrama, SM; Hop, WC; Pieters, R; te Winkel, ML; van Beek, RD; van den Heuvel-Eibrink, MM; van der Sluis, IM	1
Caceres-Marzal, C; Casado, MS; de Murillo, SG; Gervasini, G; Jimenez, M; Vagace, JM	1
Evans, WE; Panetta, JC; Pui, CH; Relling, MV; Sparreboom, A	1
Greenberg, M; Grupp, S; Kennedy, DA; Koren, G	1
Chukoskie, L; Kamen, BA	1
Bohanec Grabar, P; Dolžan, V; Faganel Kotnik, B; Grabnar, I; Jazbec, J	1
Bondy, M; Brouwers, P; Dreyer, Z; El-Zein, RA; Etzel, CJ; Harris, LL; Holm, S; Kamdar, KY; Krull, KR; Okcu, MF; Potter, BS; Scaglia, F	1
Waber, DP	1
Liu, L; Ma, X; Mi, Y; Qiu, L; Wang, J; Xiao, Z; Yang, L	1
McNeer, JL	1
Aldrich, MC; Barcellos, LF; Block, G; Buffler, PA; Chang, JS; Chokkalingam, AP; Guha, N; Hansen, HM; Kiley, V; Metayer, C; Scélo, G; Urayama, KY; Wiemels, JL; Wiencke, JK	1
Debeljak, M; Dolžan, V; Erčulj, N; Jazbec, J; Kotnik, BF	1
Mathews, CK	1
Amigou, A; Baruchel, A; Bertrand, Y; Chastagner, P; Clavel, J; Ducassou, S; Goujon-Bellec, S; Haouy, S; Hémon, D; Leverger, G; Michel, G; Nelken, B; Orsi, L; Plat, G; Rialland, X; Rudant, J	1
Digumarti, R; Dorababu, P; Gundeti, S; Kutala, VK; Linga, VG; Nagesh, N; Naushad, SM; Reddanna, P	1
Kamdar, KY; Lupo, PJ; Nousome, D; Okcu, MF; Scheurer, ME	1
Armstrong, BK; Attia, J; Bailey, HD; de Klerk, NH; Langridge, A; Miller, M; Milne, E; Scott, RJ; van Bockxmeer, FM	1
Bertino, JR; Tedeschi, PM; Vazquez, A	1
Fontes, AC; Marques-Salles, Tde J; Muniz, MT; Pombo-de-Oliveira, MS; Ramos, FJ; Sant'Ana, TA; Silva, KA; Silva, RM	1
French, AE; Grant, R; Greenberg, M; Koren, G; Ray, JG; Sung, L; Vermeulen, MJ; Weitzman, S	1
Cheng, Q; Cheok, M; Downing, JR; Evans, WE; Kager, L; Panetta, JC; Pui, CH; Relling, MV; Yang, W; Zaza, G	1
de Jonge, R; Hooijberg, JH; Jansen, G; Kaspers, GJ; Lindemans, J; Peters, FG; Peters, GJ; Pieters, R; Ravindranath, Y; van Zantwijk, CH; van Zelst, BD	1
Buffler, PA; Gunn, L; Ma, X; McHale, CM; Skibola, CF; Smith, MT; Wiemels, JL; Wiencke, JK; Zhang, L; Zheng, S	1
Radivoyevitch, T	1
Bajciova, V; Demlova, R; Sterba, J; Valik, D	1
Bartram, C; Burwinkel, B; Flohr, T; Gast, A; Hemminki, K; Kumar, R; Thirumaran, RK	1
Aboukameel, A; Buck, S; Flatley, RM; Ge, Y; Haska, C; Liu, M; Matherly, LH; Mohammad, R; Payton, SG; Taub, JW	1
Armstrong, BK; Baker, D; de Klerk, NH; Kees, UR; Milne, E; Thompson, JR; van Bockxmeer, F	1
Demlova, R; Dusek, L; Sterba, J; Valik, D	1
Jackson, RC; Loparo, KA; Radivoyevitch, T; Sedwick, WD	1
Cho, HC; Cho, HI; Hur, M; Lee, KM; Park, JY; Shin, HY	1
Costea, I; Graziani, A; Krajinovic, M; Laverdiere, C; Moghrabi, A	1
Krajinovic, M; Labuda, D; N'Diaye, N; Sinnett, D	1
Cole, PD; Kamen, BA	1
Bartram, CR; Bermejo, JL; Burwinkel, B; Flohr, T; Gast, A; Hemminki, K; Kumar, R; Schrappe, M; Stanulla, M	1
Hongeng, S; Kajanachumpol, S; Kanchanakamhaeng, K; Pakakasama, S; Sirachainan, N; Thithapandha, A; Udomsubpayakul, U	1
Janez, J; Petra, BG; Vita, D	1
Dockerty, JD; Elwood, M; Herbison, P; Skegg, DC	1
Coconi-Linares, LN; Garcés-Eisele, J; Reyes-Núñez, V; Ruiz-Argüelles, GJ	1
Ansari, M; Dulucq, S; Gagné, V; Krajinovic, M; Labuda, D; Moghrabi, A; Sinnett, D; St-Onge, G	1
de Jonge, R; Huang, L; Pieters, R; Tissing, WJ; van Zelst, BD	1
Appaji, L; Chandy, S; Krishnamoorthy, L; Ramaswamy, G; Sadananda Adiga, MN	1
Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ	1
Beardsley, GP; Bunni, MA; Leffert, JJ; Pavlovic, M; Pizzorno, G; Priest, DG; Russello, O	1
Gibson, W; Jackman, AL; Kimbell, R; Kobayashi, H; Miyachi, H; Takemura, Y	1
Bertino, JR; Elisseyeff, Y; Flintoff, WF; Goker, E; Gorlick, R; Mazumdar, M; Steinherz, P; Trippett, T	1
Kobayashi, H; Ohnuma, T; Takemura, Y	1
Baggott, JE; Johanning, GL	1
Hanrahan, LR; Phillips, DL; Sallah, S	1
Matherly, LH; Taub, JW	1
Jeanteur, P	1
Baker, SJ; Benkovic, SJ; Boger, DL; Castro, RA; Hedrick, MP; Jin, Q; Marsilje, TH; Shim, JH	1
Hoffbrand, AV; Weir, DG	1
Armstrong, BK; Gerald, PF; Thompson, JR; Willoughby, ML	1
Cartwright, RA; Hubbard, A; Law, GR; Morgan, GJ; Roberts, AC; Rollinson, S; Roman, E; Shane, B; Skibola, CF; Smith, MT	1
Ohnuma, T; Takemura, Y	1
Cheo, DL; Graham, ML; Harrison, MP; Kamen, BA; Leventhal, BG; Pullen, DJ; Shuster, JJ; Whitehead, VM	1
Miyachi, H; Ohnuma, T; Sekiguchi, S; Takemura, Y	1
Refsum, H; Ueland, PM; Wesenberg, F	1
Abels, J; Ermens, AA; Lindemans, J; Schoester, M	1
Clausen, N; Ostergård, E; Pressler, T; Schrøder, H	1

Reviews

8 review(s) available for folic acid and Acute Lymphoid Leukemia

Article	Year
Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:7 Topics: Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Liver-Specific Organic Anion Transporter 1; Metabolic Networks and Pathways; Methotrexate; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase	2015
Gene polymorphisms in childhood ALL. Pediatric blood & cancer, 2009, Volume: 52, Issue:3 Topics: Child; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Folic Acid; Humans; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2009
New therapeutic strategies in acute lymphoblastic leukemia. Seminars in hematology, 2009, Volume: 46, Issue:1 Topics: Adult; Antibodies, Monoclonal; Antineoplastic Agents; Child; Child, Preschool; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Delivery Systems; Folic Acid; Humans; Nucleosides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors	2009
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. British journal of haematology, 2010, Volume: 148, Issue:1 Topics: Child; Folic Acid; Genes, Neoplasm; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2010
Molecular biomarkers for the study of childhood leukemia. Toxicology and applied pharmacology, 2005, Aug-07, Volume: 206, Issue:2 Topics: Biomarkers; Child; DNA Methylation; Folic Acid; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute; NAD(P)H Dehydrogenase (Quinone); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Translocation, Genetic	2005
[Genetic determinants of childhood leukemia]. Bulletin du cancer, 2006, Volume: 93, Issue:9 Topics: Adolescent; Carcinogens; Child; Cytochrome P-450 Enzyme System; Environment; Female; Folic Acid; Genetic Predisposition to Disease; Glutathione Transferase; Humans; Male; Maternal Exposure; Oxidative Stress; Paternal Exposure; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2006
Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Mental retardation and developmental disabilities research reviews, 2006, Volume: 12, Issue:3 Topics: Antineoplastic Agents; Brain; Child; Cranial Irradiation; Demyelinating Diseases; Developmental Disabilities; Folic Acid; Humans; Intellectual Disability; Neuropsychological Tests; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Risk Factors	2006
Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia. Leukemia & lymphoma, 1999, Volume: 35, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Child; Disease Progression; Folic Acid; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Factors	1999

Trials

2 trial(s) available for folic acid and Acute Lymphoid Leukemia

Article	Year
Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells. PLoS computational biology, 2010, Dec-02, Volume: 6, Issue:12 Topics: Cell Division; Cohort Studies; Computational Biology; Computer Simulation; Drug Resistance, Neoplasm; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2010
Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: a Pediatric Oncology Group pilot study. Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Drug Monitoring; Erythrocytes; Folic Acid; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors	1992

Article

Year

Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.

PLoS computational biology, 2010, Dec-02, Volume: 6, Issue:12

Topics: Cell Division; Cohort Studies; Computational Biology; Computer Simulation; Drug Resistance, Neoplasm; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2010

Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: a Pediatric Oncology Group pilot study.

Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:3

Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Drug Monitoring; Erythrocytes; Folic Acid; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors

1992

Other Studies

97 other study(ies) available for folic acid and Acute Lymphoid Leukemia

Article	Year
Simultaneous determination of folate and methotrexate metabolites in serum by LC-MS/MS during high-dose methotrexate therapy. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Dec-01, Volume: 1186 Topics: Antineoplastic Agents; Chromatography, Liquid; Dose-Response Relationship, Drug; Folic Acid; Humans; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tandem Mass Spectrometry	2021
Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls. The American journal of clinical nutrition, 2022, 12-19, Volume: 116, Issue:6 Topics: Child; Diet; Dietary Supplements; DNA; DNA Methylation; Folic Acid; Humans; Infant, Newborn; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2022
Nutritional Status of Pediatric Patients With Acute Lymphoblastic Leukemia Under Chemotherapy: A Pilot Longitudinal Study. Journal of pediatric hematology/oncology, 2023, Jul-01, Volume: 45, Issue:5 Topics: Adolescent; Child; Child, Preschool; Folic Acid; Humans; Infant; Longitudinal Studies; Nutritional Status; Prealbumin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies	2023
Genetic variants, neurocognitive outcomes, and functional neuroimaging in survivors of childhood acute lymphoblastic leukemia. JNCI cancer spectrum, 2023, 07-03, Volume: 7, Issue:4 Topics: Female; Folic Acid; Functional Neuroimaging; Glucocorticoids; Humans; Male; Peptidylprolyl Isomerase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors; Tacrolimus Binding Proteins	2023
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia. PloS one, 2019, Volume: 14, Issue:9 Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12	2019
EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes & development, 2020, 11-01, Volume: 34, Issue:21-22 Topics: Animals; Carbon; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Interleukin-7; Mice; PAX5 Transcription Factor; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Protein Binding; Proto-Oncogene Proteins c-myc; Signal Transduction; Single-Cell Analysis; Trans-Activators	2020
Maternal Red Blood Cell Folate and Infant Vitamin B Molecular nutrition & food research, 2018, Volume: 62, Issue:22 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adaptor Proteins, Signal Transducing; Animals; Basic Helix-Loop-Helix Transcription Factors; DNA Methylation; Erythrocytes; Female; Folic Acid; Humans; Infant; Infant, Newborn; Kv1.1 Potassium Channel; Male; Membrane Proteins; Mice, Inbred C57BL; Mothers; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Vitamin B 12	2018
Methotrexate induces astrocyte apoptosis by disrupting folate metabolism in the mouse juvenile central nervous system. Toxicology letters, 2019, Volume: 301 Topics: Animals; Apoptosis; Astrocytes; Caspase 3; Cell Line, Tumor; Central Nervous System; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Methotrexate; Mice; Mice, Inbred C57BL; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Tetrahydrofolate Dehydrogenase	2019
Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology, 2019, Volume: 83, Issue:4 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Retrospective Studies; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase	2019
Profile of anemia in acute lymphoblastic leukemia patients on maintenance therapy and the effect of micronutrient supplementation. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020, Volume: 28, Issue:2 Topics: Adolescent; Adult; Anemia, Macrocytic; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Hemoglobins; Humans; Infant; Iron Deficiencies; Male; Micronutrients; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult	2020
Blood levels of folate at birth and risk of childhood leukemia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013, Volume: 22, Issue:6 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Time Factors	2013
Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis. PloS one, 2013, Volume: 8, Issue:8 Topics: Adolescent; Adult; Bayes Theorem; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Infant; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Young Adult	2013
Gene-environment interactions and the risk of childhood acute lymphoblastic leukemia: exploring the role of maternal folate genes and folic Acid fortification. Pediatric hematology and oncology, 2014, Volume: 31, Issue:2 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Gene-Environment Interaction; Humans; Infant; Infant, Newborn; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2014
Using a Bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads. PloS one, 2013, Volume: 8, Issue:12 Topics: Bayes Theorem; Folic Acid; Genetic Association Studies; Humans; Metabolic Networks and Pathways; Models, Genetic; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Texas	2013
Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia. British journal of haematology, 2014, Volume: 166, Issue:3 Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA-Binding Proteins; Female; Folic Acid; Gene Frequency; Genetic Variation; Genotype; Humans; Infant; Male; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transcription Factors	2014
Serum alpha tocopherol, vitamin B12, and folate levels in childhood acute lymphoblastic leukemia survivors with and without neuropathy. Journal of child neurology, 2015, Volume: 30, Issue:6 Topics: Adolescent; alpha-Tocopherol; Child; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Micronutrients; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Survivors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin E; Vitamin E Deficiency	2015
Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE study. Cancer causes & control : CCC, 2014, Volume: 25, Issue:10 Topics: Abortion, Spontaneous; Adolescent; Adult; Birth Order; Case-Control Studies; Child; Child, Preschool; Confidence Intervals; Contraceptive Agents; Dietary Supplements; Female; Folic Acid; France; Humans; Infant; Infant, Newborn; Leukemia, Myeloid, Acute; Male; Odds Ratio; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prenatal Exposure Delayed Effects; Reproductive History; Reproductive Techniques, Assisted; Risk Assessment; Risk Factors; Socioeconomic Factors; Stillbirth; Surveys and Questionnaires	2014
Role of folate status and methylenetetrahydrofolate reductase genotype on the toxicity and outcome of induction chemotherapy in children with acute lymphoblastic leukemia. Leukemia & lymphoma, 2015, Volume: 56, Issue:5 Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Folic Acid; Genotype; Humans; Induction Chemotherapy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome	2015
Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring: a Childhood Leukemia International Consortium study. Epidemiology (Cambridge, Mass.), 2014, Volume: 25, Issue:6 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Humans; Infant; Infant, Newborn; Leukemia, Myeloid, Acute; Male; Maternal-Fetal Exchange; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Risk; Risk Factors; Vitamins	2014
Are concerns about folic acid supplementation in children with acute lymphoblastic leukemia justified? Indian pediatrics, 2014, Volume: 51, Issue:9 Topics: Antineoplastic Agents; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2014
Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia. Cancer causes & control : CCC, 2014, Volume: 25, Issue:12 Topics: Adolescent; Adult; Australia; Case-Control Studies; Child; Child, Preschool; Diet; Dietary Supplements; Fathers; Female; Folic Acid; Humans; Infant; Infant, Newborn; Logistic Models; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Vitamin B Complex	2014
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia. The pharmacogenomics journal, 2015, Volume: 15, Issue:3 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Genotype; Humans; Infant; Male; Methotrexate; Mucositis; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies	2015
Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:1 Topics: Adolescent; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Risk Factors	2015
The association of folate pathway and DNA repair polymorphisms with susceptibility to childhood acute lymphoblastic leukemia. Gene, 2015, May-15, Volume: 562, Issue:2 Topics: Case-Control Studies; Child; Child, Preschool; DNA Glycosylases; DNA Mutational Analysis; DNA Repair; DNA-Binding Proteins; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rad51 Recombinase; Thymidylate Synthase	2015
Nutritional Status and Induction Chemotherapy for Acute Lymphoblastic Leukemia. Indian pediatrics, 2015, Volume: 52, Issue:5 Topics: Female; Folic Acid; Humans; Induction Chemotherapy; Male; Nutritional Status; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12	2015
Vitamin B12 and Folic Acid: Significance in Human Health. Indian pediatrics, 2015, Volume: 52, Issue:5 Topics: Female; Folic Acid; Humans; Induction Chemotherapy; Male; Nutritional Status; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12	2015
Effect of Pre-treatment Nutritional Status, Folate and Vitamin B12 Levels on Induction Chemotherapy in Children with Acute Lymphoblastic Leukemia. Indian pediatrics, 2015, Volume: 52, Issue:5 Topics: Child; Child, Preschool; Female; Folic Acid; Humans; Induction Chemotherapy; Male; Nutritional Status; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Energy Malnutrition; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency	2015
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leukemia; Leukemia, Myeloid; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Sex Factors; Surveys and Questionnaires; Thymidylate Synthase; Young Adult	2016
Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia. European journal of pharmacology, 2015, Dec-15, Volume: 769 Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Gene Frequency; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2015
Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. Cancer causes & control : CCC, 2016, Volume: 27, Issue:7 Topics: Adolescent; Adult; California; Carbon; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Energy Intake; Female; Folic Acid; Hispanic or Latino; Humans; Infant; Infant, Newborn; Logistic Models; Male; Maternal Health; Methionine; Odds Ratio; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prenatal Care; Riboflavin; Risk Factors; Vitamin B 12; Vitamin B 6	2016
PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy. Scientific reports, 2016, 07-25, Volume: 6 Topics: Adaptor Proteins, Signal Transducing; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Mercaptopurine; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases	2016
Childhood Leukemia: A Preventable Disease. Pediatrics, 2016, Volume: 138, Issue:Suppl 1 Topics: Air Pollution; Breast Feeding; Child; Environmental Exposure; Female; Folic Acid; Humans; Infant; Leukemia, Myeloid, Acute; Pesticides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Risk Factors; Tobacco Smoke Pollution	2016
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity. Pediatric blood & cancer, 2009, Volume: 52, Issue:1 Topics: Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2009
Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood, 2009, Mar-05, Volume: 113, Issue:10 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Child; Child, Preschool; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Infant; Infant, Newborn; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Nicotinamide N-Methyltransferase; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Thymidylate Synthase	2009
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. Pediatric neurology, 2009, Volume: 40, Issue:1 Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult	2009
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia. Blood, 2009, Apr-30, Volume: 113, Issue:18 Topics: Adult; Alternative Splicing; Blotting, Northern; Cell Proliferation; Drug Resistance, Neoplasm; Exons; Folic Acid; Folic Acid Antagonists; Humans; Immunoenzyme Techniques; Introns; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution	2009
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity. Pediatric blood & cancer, 2009, Volume: 53, Issue:1 Topics: Adolescent; Brain Infarction; Child; Child, Preschool; Demyelinating Diseases; Facial Paralysis; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2009
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochemical pharmacology, 2009, Apr-15, Volume: 77, Issue:8 Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Child; Drug Resistance, Neoplasm; Folic Acid; Gene Expression Profiling; Humans; Methotrexate; Nucleotides; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes	2009
DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: is the risk reduction due to intracellular folate unbalancing? American journal of hematology, 2009, Volume: 84, Issue:8 Topics: Adult; Aged; Folic Acid; Genetic Predisposition to Disease; Humans; INDEL Mutation; Italy; Methylenetetrahydrofolate Dehydrogenase (NAD+); Middle Aged; Neoplasm Proteins; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase	2009
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival. Haematologica, 2009, Volume: 94, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Tetrahydrofolate Dehydrogenase; Young Adult	2009
Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood, 2010, May-13, Volume: 115, Issue:19 Topics: Case-Control Studies; Folic Acid; Genetic Variation; Glycine Hydroxymethyltransferase; Humans; Leukemia, Myeloid, Acute; Methylenetetrahydrofolate Reductase (NADPH2); Phosphotransferases (Alcohol Group Acceptor); Precursor Cell Lymphoblastic Leukemia-Lymphoma	2010
Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematological oncology, 2011, Volume: 29, Issue:3 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Indonesia; Infant; Infant, Newborn; Male; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Xenobiotics	2011
Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study. Bone, 2011, Mar-01, Volume: 48, Issue:3 Topics: Absorptiometry, Photon; Adolescent; Biomarkers, Tumor; Bone Density; Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Fractures, Bone; Genotype; Germ Cells; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12	2011
Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis. American journal of hematology, 2011, Volume: 86, Issue:1 Topics: Antimetabolites, Antineoplastic; Child, Preschool; Female; Folic Acid; Humans; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2011
Folate fortification and survival of children with acute lymphoblastic leukemia. Paediatric drugs, 2011, Jun-01, Volume: 13, Issue:3 Topics: Child; Child, Preschool; Databases, Factual; Folic Acid; Folic Acid Antagonists; Food, Fortified; Humans; Infant; Infant, Newborn; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Analysis; Treatment Failure; World Health Organization	2011
Autism Speaks: meeting on folate metabolism and Autism spectrum disorders, March 19-20, 2009, Washington, DC. Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:3 Topics: Autistic Disorder; Biological Transport; Brain; Cognition Disorders; District of Columbia; Folic Acid; Genomic Instability; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, N-Methyl-D-Aspartate; Vitamin B 12	2011
Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. European journal of clinical pharmacology, 2011, Volume: 67, Issue:10 Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child, Preschool; Female; Folic Acid; Genotype; Humans; Lymphoma; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Nonlinear Dynamics; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Retrospective Studies; Thrombocytopenia	2011
Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy. Pediatric blood & cancer, 2011, Volume: 57, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Antineoplastic Agents; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cognition Disorders; Female; Folic Acid; Genotype; Humans; Infant; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors	2011
Central nervous system late effects: a new frontier? Pediatric blood & cancer, 2011, Volume: 57, Issue:3 Topics: Antineoplastic Agents; Cognition Disorders; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2011
Polymorphisms in folate-related genes: impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese. Leukemia & lymphoma, 2011, Volume: 52, Issue:9 Topics: Adolescent; Adult; Alleles; Asian People; Child; Child, Preschool; China; Female; Folic Acid; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; Genotype; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Young Adult	2011
The complex interplay between folate metabolism and risk of acute lymphoblastic leukemia. Leukemia & lymphoma, 2011, Volume: 52, Issue:9 Topics: Female; Folic Acid; Humans; Male; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2011
Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer causes & control : CCC, 2011, Volume: 22, Issue:9 Topics: Alcohol Drinking; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Haplotypes; Humans; Infant; Infant, Newborn; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors	2011
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia. Leukemia & lymphoma, 2012, Volume: 53, Issue:6 Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Female; Folic Acid; Genotype; Humans; Infant; Infant, Newborn; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Thymidylate Synthase	2012
DNA synthesis as a therapeutic target: the first 65 years. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:6 Topics: Aminopterin; Antimetabolites, Antineoplastic; DNA Replication; Fluorouracil; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Hydroxyurea; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase	2012
Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE). Cancer causes & control : CCC, 2012, Volume: 23, Issue:8 Topics: Case-Control Studies; Child, Preschool; Dietary Supplements; Female; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications	2012
Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL. Pharmacogenomics, 2012, Volume: 13, Issue:9 Topics: Adolescent; Biomarkers, Pharmacological; Child; Child, Preschool; Female; Folic Acid; Genetic Association Studies; Glutamate Carboxypeptidase II; Haplotypes; Humans; Male; Mercaptopurine; Metabolic Networks and Pathways; Methotrexate; Methyltransferases; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases	2012
A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia. Cancer causes & control : CCC, 2012, Volume: 23, Issue:11 Topics: Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2012
Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and the risk of childhood acute lymphoblastic leukemia. Nutrition and cancer, 2012, Volume: 64, Issue:7 Topics: Acute Disease; Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Diet; Female; Folic Acid; Humans; Infant; Logistic Models; Maternal Nutritional Physiological Phenomena; Nutrition Assessment; Odds Ratio; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prospective Studies; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6	2012
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. Cancer research, 2013, Jan-15, Volume: 73, Issue:2 Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondria; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serine; Transcriptome	2013
Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia. Genetic testing and molecular biomarkers, 2013, Volume: 17, Issue:2 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Replication Protein C; Risk; Thymidylate Synthase; Young Adult	2013
Folic acid food fortification is associated with a decline in neuroblastoma. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:3 Topics: Canada; Child; Child, Preschool; Cross-Sectional Studies; Databases, Factual; Folic Acid; Food, Fortified; Hepatoblastoma; Humans; Liver Neoplasms; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies	2003
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. The Journal of clinical investigation, 2005, Volume: 115, Issue:1 Topics: Cluster Analysis; DNA; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Leukocyte Count; Lymphocytes; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Messenger; Thymidylate Synthase	2005
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood, 2005, Jul-15, Volume: 106, Issue:2 Topics: Antimetabolites, Antineoplastic; Child; Drug Resistance, Neoplasm; Ferredoxin-NADP Reductase; Folic Acid; Genetic Variation; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2005
Folate system correlations in DNA microarray data. BMC cancer, 2005, Aug-04, Volume: 5 Topics: Algorithms; Cell Proliferation; Computational Biology; Data Interpretation, Statistical; DNA Damage; DNA Repair; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Models, Biological; Models, Chemical; Models, Theoretical; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Radiation, Ionizing; RNA, Messenger; Thymidylate Synthase; Time Factors	2005
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. Oncology, 2005, Volume: 69, Issue:3 Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases, Metabolic; Child; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2005
MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood, 2005, Oct-01, Volume: 106, Issue:7 Topics: Alleles; Case-Control Studies; Child; Child, Preschool; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Risk Factors	2005
Transcriptional regulation of the human reduced folate carrier in childhood acute lymphoblastic leukemia cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jan-15, Volume: 12, Issue:2 Topics: Animals; Base Sequence; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Electrophoretic Mobility Shift Assay; Exons; Female; Folic Acid; GATA1 Transcription Factor; Gene Expression Regulation; Humans; Ikaros Transcription Factor; Membrane Transport Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Sequence Data; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Protein Isoforms; Reduced Folate Carrier Protein; Sp1 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Transfection; Transplantation, Heterologous; Upstream Stimulatory Factors	2006
Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia? International journal of cancer, 2006, Jul-01, Volume: 119, Issue:1 Topics: Alanine; Bone Marrow; Child; Child, Preschool; Cysteine; Dietary Supplements; DNA, Neoplasm; Female; Folic Acid; Genotype; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Threonine	2006
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited. Clinical chemistry, 2006, Volume: 52, Issue:4 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex	2006
On systems and control approaches to therapeutic gain. BMC cancer, 2006, Apr-25, Volume: 6 Topics: Antineoplastic Agents; Core Binding Factor Alpha 2 Subunit; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Folic Acid; Fusion Proteins, bcr-abl; Humans; Idoxuridine; Models, Biological; Neoplasms; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation-Sensitizing Agents; Systems Biology; Systems Theory	2006
Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population. Clinical and laboratory haematology, 2006, Volume: 28, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Confidence Intervals; Female; Folic Acid; Gene Frequency; Humans; Infant; Korea; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Assessment	2006
Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia. Haematologica, 2006, Volume: 91, Issue:8 Topics: Child; Disease-Free Survival; Folic Acid; Folic Acid Antagonists; Hematologic Diseases; Humans; Liver; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2006
Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study. Leukemia, 2007, Volume: 21, Issue:2 Topics: Adolescent; Adult; Base Sequence; Case-Control Studies; Child; Child, Preschool; DNA, Neoplasm; Female; Folic Acid; Genotype; Humans; Male; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values	2007
Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia. Annals of hematology, 2007, Volume: 86, Issue:8 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant; Male; Methotrexate; Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2007
Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children. Leukemia & lymphoma, 2007, Volume: 48, Issue:4 Topics: Adolescent; Adult; Child; Female; Folic Acid; Genotype; Humans; Male; Metabolic Networks and Pathways; Models, Biological; Models, Genetic; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Interaction Mapping; Risk	2007
Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study. BMC public health, 2007, Jul-03, Volume: 7 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Humans; Infant; Infant, Newborn; Iron, Dietary; Logistic Models; Minerals; New Zealand; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Risk Assessment; Risk Factors; Surveys and Questionnaires; Treatment Outcome; Vitamins	2007
Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico. Hematology (Amsterdam, Netherlands), 2007, Volume: 12, Issue:5 Topics: Adolescent; Adult; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Diet; Female; Folic Acid; Humans; Infant; Infant, Newborn; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mucositis; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors	2007
DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL. Blood, 2008, Apr-01, Volume: 111, Issue:7 Topics: Alleles; Antimetabolites, Antineoplastic; Cyclin D; Cyclins; Disease-Free Survival; DNA, Neoplasm; Female; Folic Acid; Haplotypes; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Survival Rate; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transcription, Genetic	2008
Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia. Leukemia, 2008, Volume: 22, Issue:9 Topics: Child; DNA Mutational Analysis; Folic Acid; Gene Frequency; Genotype; Humans; Metabolic Networks and Pathways; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2008
Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia. Indian journal of pediatrics, 2008, Volume: 75, Issue:3 Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Discriminant Analysis; Female; Folic Acid; Homocysteine; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12	2008
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19 Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured	1995
Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF). Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Binding Sites; Biological Transport; Carrier Proteins; Cell Line; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tetrahydrofolates; Tumor Cells, Cultured	1993
Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug. Journal of cancer research and clinical oncology, 1996, Volume: 122, Issue:2 Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Humans; Intracellular Fluid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Tritium; Tumor Cells, Cultured	1996
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood, 1997, Feb-01, Volume: 89, Issue:3 Topics: Adolescent; Adult; Aged; Biological Transport; Blast Crisis; Carrier Proteins; Child; Child, Preschool; Drug Resistance; Fluoresceins; Folic Acid; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein	1997
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates. Cancer letters, 1998, Feb-27, Volume: 124, Issue:2 Topics: Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured	1998
10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. The Journal of nutrition, 1999, Volume: 129, Issue:7 Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Hematinics; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1999
Intrathecal methotrexate-induced megaloblastic anemia in patients with acute leukemia. Archives of pathology & laboratory medicine, 1999, Volume: 123, Issue:9 Topics: Adult; Anemia, Megaloblastic; Antimetabolites, Antineoplastic; Female; Folic Acid; Humans; Injections, Spinal; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies	1999
[Nutrition, genetic polymorphism, and cancer]. Bulletin du cancer, 2000, Volume: 87, Issue:2 Topics: Colorectal Neoplasms; DNA; DNA Repair; Folic Acid; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Tetrahydrofolates; Thymidine; Uridine	2000
Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. Bioorganic & medicinal chemistry letters, 2000, Jul-03, Volume: 10, Issue:13 Topics: Animals; Biological Assay; Combinatorial Chemistry Techniques; Drug Design; Enzyme Inhibitors; Fluorine; Folic Acid; Hydroxymethyl and Formyl Transferases; Molecular Structure; Nitro Compounds; Phosphoribosylglycinamide Formyltransferase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Ribonucleotides; Tumor Cells, Cultured	2000
The history of folic acid. British journal of haematology, 2001, Volume: 113, Issue:3 Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency	2001
Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet (London, England), 2001, Dec-08, Volume: 358, Issue:9297 Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Data Collection; Dietary Supplements; Female; Folic Acid; Humans; Infant; Infant, Newborn; Iron, Dietary; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Risk Factors; Western Australia	2001
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood, 2002, May-15, Volume: 99, Issue:10 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Male; Middle Aged; Models, Chemical; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase	2002
N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate. The Mount Sinai journal of medicine, New York, 1992, Volume: 59, Issue:5 Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured	1992
A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717). Journal of cancer research and clinical oncology, 1991, Volume: 117, Issue:6 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cisplatin; Cross Reactions; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Folic Acid; Humans; Leucovorin; Membrane Glycoproteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; RNA, Messenger; Thymidylate Synthase; Trimetrexate; Vincristine	1991
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate. Cancer research, 1991, Feb-01, Volume: 51, Issue:3 Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors	1991
Effect of nitrous oxide and methotrexate on folate coenzyme pools of blast cells from leukemia patients. Leukemia research, 1991, Volume: 15, Issue:2-3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Vitamin B 12	1991
Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Pediatric hematology and oncology, 1986, Volume: 3, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Contraindications; Drug Interactions; Drug Tolerance; Folic Acid; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis	1986