folic acid has been researched along with Abnormality, Heart in 133 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.50) | 18.7374 |
| 1990's | 6 (4.51) | 18.2507 |
| 2000's | 42 (31.58) | 29.6817 |
| 2010's | 60 (45.11) | 24.3611 |
| 2020's | 23 (17.29) | 2.80 |
| Authors | Studies |
|---|---|
| Harley, KG; Nguyen, VH | 1 |
| Jin, L; Meng, W; Ren, A; Wang, D; Zhang, J | 1 |
| Brei, TJ; Farr, SL; Kirby, RS; Leedom, VO; Pabst, LJ; Riley, C; Van Zutphen, AR | 1 |
| Attri, SV; Dash, N; Rohit, MK; Sankhyan, N; Tyagi, R; Verma, S | 1 |
| Cheng, Z; Gu, HF; Gu, R; Lian, Z | 1 |
| Caputo, M; Mires, S; Overton, T; Skerritt, C | 1 |
| Chen, H; Chen, X; Dou, Y; Huang, G; Huang, X; Jia, B; Jiang, Y; Li, M; Ma, X; Sheng, W; Wang, D; Wang, Y; Yan, W; Zhang, Y | 1 |
| Dai, L; Deng, C; Deng, Y; Guo, X; Liu, H; Liu, L; Pu, J; Sandin, S; Xie, L; Yu, L | 1 |
| Aniagu, S; Chen, J; Chen, T; Jiang, Y; Zhang, M; Zou, H | 1 |
| Cheng, Y; Cheng, Z; Gu, HF; Gu, R; He, M; Lian, Z; Wang, Y; Wu, C; Wu, Z | 1 |
| Erickson, SW; Hobbs, CA; Karim, MA; Levy, JW; Li, M; MacLeod, SL; Tang, X; Webber, DM | 1 |
| Cao, J; Cao, L; Chen, ZZ; Gu, WJ; Li, L; Sun, K; Xiang, J; Xu, B; Zang, WD; Zhao, JY; Zhao, R; Zhou, XY; Zhou, ZY | 1 |
| Chen, Q; Chen, Y; Liu, H; Luo, M; Ou, J; Qin, J; Wang, T | 1 |
| Boyle, B; Bunting, B; Callaghan, S; Casey, F; Craig, B; Dabir, T; Dolk, H; Given, J; Lagan, BM; Loane, M; McCullough, N | 1 |
| Bloom, MS; Gao, X; Lin, S; Liu, X; Mai, J; Nie, Z; Ou, Y; Qu, Y; Smith, M; Tan, H; Wu, Y; Zhuang, J | 1 |
| Soheilirad, Z | 1 |
| Bloom, MS; Chen, J; Gao, X; Lin, S; Liu, X; Mai, J; Nie, Z; Ou, Y; Qu, Y; Tan, H; Wang, X; Wu, Y; Xiao, X; Ye, B; Zhuang, J | 1 |
| Dang, S; Guo, L; Qu, P; Yan, H; Zhang, R; Zhao, D | 1 |
| Chen, L; Diao, J; Huang, P; Li, F; Li, J; Li, Y; Luo, L; Qin, J; Sun, M; Wang, T; Zhang, S; Zhu, P | 1 |
| Ancer-Rodríguez, PR; Calvo-Anguiano, G; Calzada-Dávila, M; Campos-Acevedo, LD; González-Peña, SM; Guerrero-Orjuela, LS; Hernández-Almaguer, MD; Lugo-Trampe, JJ; Martínez-de-Villarreal, LE; Saldivar-Rodríguez, D | 1 |
| Agarwal, S; Asim, A | 1 |
| Aylsworth, AS; Botto, LD; Carmichael, SL; Correa, A; Gilboa, SM; Langlois, PH; Luben, TJ; Nembhard, WN; Olshan, AF; Richmond-Bryant, J; Shaw, GM; Stingone, JA | 1 |
| Baumert, M; Paprotny, M; Surmiak, P | 1 |
| Elizabeth, KE; Jissa, VT; Pillai, MR; Praveen, SL; Preethi, NR | 1 |
| Akhtar, MS; Tahir, M | 1 |
| Cui, H; Dai, W; He, X; Huang, H; Lin, X; Liu, Q; Lv, L; Mao, B; Qiu, J; Qiu, W; Shao, Y; Tang, Z; Xu, S; Xu, X; Zhang, Y; Zhao, N; Zhou, M | 1 |
| Cai, J; Chen, R; Feng, Y; Mo, X; Tong, X; Xu, B; Zhu, Y | 1 |
| Duan, S; Feng, Z; Li, G; Ma, X; Qiu, F; Wang, L; Zhao, L; Zhao, M | 1 |
| Luo, L; Tian, Y; Wang, X; Wei, H; Wu, Y | 1 |
| Basit, S; Carstensen, L; Granström, C; Leirgul, E; Magnus, P; Melbye, M; Olsen, SF; Strøm, M; Tell, GS; Vollset, SE; Wohlfahrt, J; Øyen, N | 1 |
| Eum, J; Hwang, BJ; Kee, Y; Ki, S; Kim, KN; Kwon, SH; Raslan, AA | 1 |
| Bayraktar, N; Gulumser, C; Kocaman, E; Sahin-Uysal, N; Varan, B; Yanık, F | 1 |
| Chen, X; Deng, K; Deng, Y; Li, N; Li, S; Li, X; Li, Y; Lin, Y; Liu, Z; Mu, D; Wang, Y; You, F; Zhu, J | 1 |
| Carmichael, SL; Feldkamp, ML; Herring, AH; Hobbs, CA; Olshan, AF; Siega-Riz, AM; Sotres-Alvarez, D | 1 |
| Linask, KK | 1 |
| Chen, Y; Jiang, D; Li, H; Liu, M; Mao, J; Wang, B; Yan, W | 1 |
| Huhta, J; Linask, KK | 2 |
| Arning, E; Azen, C; Bottiglieri, T; Moseley, K; Yano, S | 1 |
| Marrs, JA; Sarmah, S | 1 |
| Csáky-Szunyogh, M; Czeizel, AE; Gerencsér, B; Kósa, Z; Vereczkey, A | 1 |
| Bérard, A; Richard-Tremblay, AA; Sheehy, O | 1 |
| Bentham, J; Bhattacharya, S; Blue, G; Breckpot, J; Brody, LC; Brook, JD; Brown, DL; Bu'Lock, FA; Cordell, HJ; Cosgrove, C; Devriendt, K; Doza, JP; Druschel, C; Farrall, M; Gewillig, M; Goodship, JA; Hall, D; Keavney, BD; Lathrop, GM; Mamasoula, C; Mills, JL; Moorman, AF; Mulder, BJ; O'Sullivan, J; Pangilinan, F; Pass, K; Pierscionek, T; Postma, AV; Prentice, RR; Rahman, TJ; Rauch, A; Riveron, JG; Russell, MW; Setchfield, K; Stuart, AG; Tan, HL; Thornborough, C; Töpf, A; van Engelen, K; Winlaw, D; Zelenika, D; Zwinderman, AH | 1 |
| Bedard, T; Dyck, JD; Harder, JR; Horobec, V; Lowry, RB; Sibbald, B; Trevenen, C | 1 |
| Gelb, BD | 1 |
| Bánhidy, F; Czeizel, AE; Dudás, I; Vereczkey, A | 1 |
| Cleves, MA; Erickson, SW; Hobbs, CA; Li, J; Li, M; Macleod, SL; Malik, S; Nick, T; Tang, X | 1 |
| Chen, JL; Huang, C; Tan, ZP; Wang, J; Wang, SZ; Xie, L; Yang, JF; Yang, YF; Zhang, WZ; Zhao, TL | 1 |
| Huhta, JC; Linask, K | 1 |
| Chen, R; Feng, Y; Mo, X; Tong, X; Wang, S; Wu, Z | 1 |
| Chu, SL; Ho, YL; Huang, PT; Liou, HH; Tsai, HJ; Yu, WH | 1 |
| Huang, P; Lin, N; Liu, Y; Qin, Y; Shi, H; Sun, X; Wang, L; Yang, S; Yu, R; Zhang, Y | 1 |
| Brodwall, K; Fomina, T; Gildestad, T; Greve, G; Holmstrøm, H; Leirgul, E; Nilsen, RM; Tell, GS; Vollset, SE; Øyen, N | 1 |
| Czeizel, AE; Szabó, I; Vereczkey, A | 1 |
| Jiang, Y; Liu, C; Mei, J; Qian, X; Yang, H; Zhang, S; Zhang, W | 1 |
| Han, M; Linask, KK | 1 |
| Evans, J; Joseph, KS; Kramer, MS; León, JA; Lim, K; Lisonkova, S; Little, J; Liu, S; Luo, W; Sauve, R; Van den Hof, M | 1 |
| Cao, X; Chen, X; Jiang, H; Li, H; Li, X; Lu, Y; Xu, A; Zhu, Q | 1 |
| Duan, W; Li, Y; Lu, H; Qiao, B; Shi, KH; Tao, H; Wang, D; Wang, F; Wang, H; Zhao, JY; Zhao, R; Zhao, SM | 1 |
| Assaraf, YG; Ifergan, I | 1 |
| Blom, HJ; den Heijer, M; Heil, S; Kapusta, L; Mooij, C; van Beynum, IM | 1 |
| Craig, JJ; Hunt, SJ; Irwin, B; Morrison, PJ; Morrow, JI; Parsons, L; Robertson, I; Russell, AJ; Smithson, WH; Waddell, R | 1 |
| Brown, K; Jerome-Majewska, L; Li, D; Luo, L; Mikael, LG; Pickell, L; Rozen, R; Wang, XL; Wu, Q | 1 |
| Fouron, JC; Gardiner, HM | 1 |
| Ionescu-Ittu, R; Mackie, AS; Marelli, AJ; Pilote, L | 1 |
| Memon, S; Pratten, MK | 2 |
| Barcellos, LF; Briggs, FB; Carmichael, SL; Finnell, RH; Lammer, EJ; Lu, W; Shaw, GM; Yang, W; Zhu, H | 1 |
| Schenk, M | 1 |
| Caldwell, PT; Howard, J; Manziello, A; Palbykin, B; Runyan, RB; Selmin, O | 1 |
| Alves da Silva, AF; Biselli, JM; Carvalho, VM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Machado, FB; Medina-Acosta, E; Pavarino-Bertelli, EC; Vannucchi, H; Zampieri, BL | 1 |
| Bakker, MK; Blom, HJ; de Walle, HE; den Heijer, M; Kapusta, L; van Beynum, IM | 1 |
| Fan, H; Jing, XA; Li, D; Wang, HY; Ye, WJ | 1 |
| Goldmuntz, E; Lupo, PJ; Mitchell, LE; Renstrom, D; Woyciechowski, S | 1 |
| Goldmuntz, E; Lupo, PJ; Mitchell, LE | 2 |
| Brinez, P; Han, M; Linask, KK; Serrano, M | 1 |
| Cleves, MA; Hobbs, CA; Karim, MA; MacLeod, SL; Zhao, W | 1 |
| Allen, EG; Bean, LJ; Capone, G; Cheong, SY; Cua, CL; Dooley, KJ; Epstein, MP; Feingold, E; Freeman, SB; Lin, X; Locke, AE; Sherman, SL; Tinker, SW; Torfs, CP; Wu, MC | 1 |
| de Jonge, R; Helbing, WA; Obermann-Borst, SA; Steegers, EA; Steegers-Theunissen, RP; van Driel, LM; Wildhagen, MF | 1 |
| Isaacs, A; Obermann-Borst, SA; Steegers, EA; Steegers-Theunissen, RP; van der Heiden, IP; van Duyn, CM; van Schaik, RH; Younes, Z | 1 |
| Eijkemans, MJ; Laven, JS; Lindemans, J; Smedts, HP; Steegers, EA; Steegers-Theunissen, RP; Valkenburg, O; van Uitert, EM | 1 |
| Brown, K; Deng, L; Jerome-Majewska, L; Li, D; Luo, L; Pickell, L; Rozen, R; Selhub, J; Wang, XL; Wu, Q | 1 |
| Chowdhury, S; Cleves, MA; Hobbs, CA; James, SJ; MacLeod, SL; Zhao, W | 1 |
| Cleves, MA; Hobbs, CA; Jill James, S; MacLeod, SL | 1 |
| Goldmuntz, E; Long, J; Lupo, PJ; Mitchell, LE | 1 |
| Alva-Espinoza, C; Arámbula-Meraz, E; Galaviz-Hernández, C; García-Cavazos, R; Ramírez-Dueñas, Mde L; Rangel-Villalobos, H; Sánchez-Urbina, R; Sierra-Ramírez, JA; Torres-Saldúa, R | 1 |
| Andelfinger, GU; Bigras, JL; Christensen, KE; Dubé, MP; Michaud, JL; Richter, A; Rohlicek, CV; Rozen, R; Zada, YF | 1 |
| Carmichael, SL; Etheredge, AJ; Finnell, RH; Lammer, EJ; Lu, W; Shaw, GM; Yang, W; Zhu, H | 1 |
| Arenas-Aranda, D; Balderrábano-Saucedo, NA; Bravo-Hernández, G; García-Hernández, N; Klunder-Klunder, M; Noriega-Zapata, P; Sánchez-Boiso, A; Sánchez-Urbina, R; Sierra-Ramírez, JA; Vizcaíno-Alarcón, A | 1 |
| Lewandowski, LB; Sanghavi, D | 1 |
| Chowdhury, S; Cleves, MA; Erickson, SW; Hobbs, CA; Hu, P; James, SJ; MacLeod, SL; Melnyk, S | 1 |
| Chen, Y; Wang, BJ | 1 |
| Rosenquist, TH | 1 |
| Ferguson, S; Lougheed, J; McDonald, SD; Tam, L; Walker, MC | 1 |
| Botto, LD; Erickson, JD; Mulinare, J | 1 |
| MONIE, IW; NELSON, MM | 1 |
| Finnell, RH; Lammer, EJ; Shaw, GM; Yang, W; Zhu, H | 1 |
| Cheng, J; Dao, J; Zhao, R; Zhu, W | 1 |
| Ahgelova, L; Ionov, M; Khristova, V; Kovacheva, K; Pandurski, F; Rosmanova, R; Simeonova, M; Slavov, N; Stoĭkov, S; Tsankova, G | 1 |
| Finnell, RH; Miranda, RC; Santillano, DR; Tang, LS; Wlodarczyk, BJ | 1 |
| Cheng, J; Dao, JJ; Li, MY; Li, SQ; Li, Y; Yan, LY; Zhu, WL | 1 |
| Cheng, J; Dao, JJ; Li, SQ; Li, Y; Zhu, WL | 1 |
| Bailey, LB; Berry, RJ | 1 |
| Cleves, MA; Greenhaw, JJ; Hobbs, CA; James, SJ; Jernigan, S; Krakowiak, PA; Lu, Y; Parsian, A | 1 |
| Cohn, JS; Li, D; Liu, Y; Pickell, L; Rozen, R; Wu, Q | 1 |
| Finnell, RH; Li, Z; Pei, L; Ren, A; Zhu, H; Zhu, J | 1 |
| Cleves, MA; Hobbs, CA; James, SJ; Melnyk, S; Zhao, W | 1 |
| Blom, HJ; Daniëls, O; den Heijer, M; Kapusta, L; Kouwenberg, M; van Beynum, IM; Vermeulen, SH | 1 |
| Cheng, J; Dao, JJ; Li, SQ; Zhu, WL | 1 |
| Li, D; Rozen, R | 1 |
| Bower, C; Miller, M; Payne, J; Serna, P | 1 |
| Bailey, L; Huhta, JC; Linask, K | 1 |
| de Jong-van den Berg, LT; Hernandez-Diaz, S; Louik, C; Meijer, WM; Mitchell, AA; Werler, MM | 1 |
| de Jonge, R; de Vries, JH; Hop, WC; Steegers-Theunissen, RP; Ursem, NT; Verkleij-Hagoort, AC | 1 |
| Arrieta, SR; D'Almeida, V; Galdieri, LC; Pedra, CA; Silva, CM | 1 |
| Jongbloet, PH | 1 |
| Arbour, L; Forth, M; MacDonald, S; Nowdluk, M; Osborne, G; Rupps, R; Yang, J | 1 |
| Canfield, M; Carmichael, SL; Shaw, GM; Song, J; Yang, J | 1 |
| Bian, XM; Jiang, YL; Li, SL; Liu, JT; Qi, QW; Sun, NH; Xiang, Y; Yang, JQ | 1 |
| Champion, HC; Claeys, MJ; Kass, DA; Moens, AL; Timmermans, JP; Vrints, CJ | 1 |
| de Jonge, R; Steegers, EA; Steegers-Theunissen, RP; Uitterlinden, AG; van Driel, LM; van Duijn, CM; Verkleij-Hagoort, AC | 1 |
| Lammer, EJ; O'Malley, CD; Shaw, GM; Tolarova, MM; Wasserman, CR | 1 |
| Ratashak, SA; Rosenquist, TH; Selhub, J | 1 |
| Correa-Villaseñor, A; Ferencz, C; Khoury, MJ; Loffredo, CA; Scanlon, KS; Willett, WC; Wilson, PD | 1 |
| Hall, JG; Solehdin, F | 1 |
| Leader, S; Mallick, R | 1 |
| Hernández-Díaz, S; Mitchell, AA; Walker, AM; Werler, MM | 1 |
| Eskes, TK | 1 |
| Chen, X; Li, S; Li, Y; Li, Z; Qi, P | 1 |
| Burgoon, JM; Nadeau, M; Sadler, TW; Selhub, J | 1 |
| Cooperman, JM; Lopez, R; Rook, GD; Shimizu, N | 1 |
19 review(s) available for folic acid and Abnormality, Heart
| Article | Year |
|---|---|
Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis.
Topics: Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Neural Tube Defects; Pregnancy; Prenatal Care | 2022 |
Maternal micronutrient deficiency and congenital heart disease risk: A systematic review of observational studies.
Topics: Copper; Female; Ferritins; Folic Acid; Heart Defects, Congenital; Humans; Malnutrition; Maternal Nutritional Physiological Phenomena; Micronutrients; Observational Studies as Topic; Pregnancy; Selenium; Trace Elements; Vitamin A; Vitamin B 12; Vitamin D; Zinc | 2022 |
Folic acid intake in prevention of congenital heart defects: A mini evidence review.
Topics: Female; Folic Acid; Heart Defects, Congenital; Humans; Pregnancy | 2020 |
Congenital heart defects among Down's syndrome cases: an updated review from basic research to an emerging diagnostics technology and genetic counselling.
Topics: Down Syndrome; Female; Folic Acid; Genetic Counseling; Heart Defects, Congenital; Humans; MicroRNAs; Pregnancy | 2021 |
Environmental origins of congenital heart disease: the heart-placenta connection.
Topics: Animals; Dietary Supplements; Environmental Illness; Environmental Pollutants; Female; Fetal Development; Fetal Heart; Folic Acid; Heart Defects, Congenital; Heart Diseases; Humans; Infant, Newborn; Male; Maternal Exposure; Placenta; Pregnancy; Prenatal Nutritional Physiological Phenomena | 2013 |
Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.
Topics: Alleles; Cohort Studies; Databases, Genetic; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors | 2013 |
Recent advances in understanding the genetics of congenital heart defects.
Topics: Child; Child, Preschool; DNA Copy Number Variations; Folic Acid; Gene-Environment Interaction; Genes, Modifier; Genome-Wide Association Study; Heart Defects, Congenital; Homocysteine; Humans; Infant; Molecular Sequence Data; Mutation | 2013 |
Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects.
Topics: Diet; Dietary Supplements; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Heart Defects, Congenital; Humans; Neural Tube Defects | 2013 |
When should we prescribe high-dose folic acid to prevent congenital heart defects?
Topics: Dietary Supplements; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Gestational Age; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Neural Tube Defects; Pregnancy; Prenatal Care; Primary Prevention; Prognosis; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome | 2015 |
Maternal folic acid supplementation and the risk of congenital heart defects in offspring: a meta-analysis of epidemiological observational studies.
Topics: Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Maternal Exposure; Odds Ratio; Pregnancy; Prenatal Exposure Delayed Effects; Risk | 2015 |
A Meta-Analysis of the Relationship Between Maternal Folic Acid Supplementation and the Risk of Congenital Heart Defects.
Topics: Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant, Newborn; Pregnancy; Prenatal Care; Vitamin B Complex | 2016 |
Folate protection from congenital heart defects linked with canonical Wnt signaling and epigenetics.
Topics: Animals; beta Catenin; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Regulation, Developmental; Heart; Heart Defects, Congenital; Humans; Maternal Exposure; Pregnancy; Signal Transduction; Vitamin B Complex | 2010 |
[Folic acid metabolism gene polymorphism and congenital heart disease].
Topics: Child, Preschool; Cystathionine beta-Synthase; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Minor Histocompatibility Antigens; Polymorphism, Genetic; Risk Factors | 2012 |
Folate, homocysteine and the cardiac neural crest.
Topics: Animals; DNA Methylation; Folate Receptor 1; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Mitosis; Neural Crest | 2013 |
The prevention of congenital anomalies with periconceptional folic acid supplementation.
Topics: Congenital Abnormalities; Dietary Supplements; Female; Fertilization; Folic Acid; Heart Defects, Congenital; Humans; Neural Tube Defects; Practice Guidelines as Topic; Pregnancy; Randomized Controlled Trials as Topic | 2003 |
Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage.
Topics: Abortion, Spontaneous; Cleft Palate; Female; Folic Acid; Heart Defects, Congenital; Hematinics; Humans; Infant, Newborn; Pregnancy; Pregnancy, Multiple; Vitamins | 2005 |
Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease.
Topics: Animals; Atherosclerosis; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Heart Defects, Congenital; Hemodynamics; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III | 2008 |
Folate and its various ramifications.
Topics: Cerebrovascular Disorders; Congenital Abnormalities; Coronary Disease; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Humans; Neoplasms; Neural Tube Defects; Pregnancy | 1998 |
Clotting disorders and placental abruption: homocysteine--a new risk factor.
Topics: Abruptio Placentae; Blood Coagulation Disorders; Endothelium, Vascular; Female; Fetal Growth Retardation; Folic Acid; Heart Defects, Congenital; Humans; Hyperhomocysteinemia; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Pregnancy Complications, Hematologic; Risk Factors | 2001 |
2 trial(s) available for folic acid and Abnormality, Heart
| Article | Year |
|---|---|
The prevention of congenital anomalies with periconceptional folic acid supplementation.
Topics: Congenital Abnormalities; Dietary Supplements; Female; Fertilization; Folic Acid; Heart Defects, Congenital; Humans; Neural Tube Defects; Practice Guidelines as Topic; Pregnancy; Randomized Controlled Trials as Topic | 2003 |
Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring.
Topics: Case-Control Studies; Congenital Abnormalities; Female; Fertilization; Folic Acid; Heart Defects, Congenital; Humans; Infant, Newborn; Limb Deformities, Congenital; Maternal-Fetal Exchange; Pregnancy; Vitamins | 1995 |
113 other study(ies) available for folic acid and Abnormality, Heart
| Article | Year |
|---|---|
Prenatal Cannabis Use and Infant Birth Outcomes in the Pregnancy Risk Assessment Monitoring System.
Topics: Cannabis; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Pregnancy; Premature Birth; Retrospective Studies; Risk Assessment | 2022 |
Maternal Periconceptional Folic Acid Supplementation and Risk for Fetal Congenital Heart Defects.
Topics: Cannabis; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant; Pregnancy; Risk Assessment | 2022 |
Prevention and awareness of birth defects across the lifespan using examples from congenital heart defects and spina bifida.
Topics: Folic Acid; Heart Defects, Congenital; Humans; Longevity; Spinal Dysraphism | 2022 |
Folate Deficiency: A Possible Association with Congenital Heart Defects.
Topics: Cross-Sectional Studies; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Humans; Infant; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Summary for Patients: Maternal Folate Level and Congenital Heart Disease.
Topics: Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans | 2022 |
Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Topics: Biomarkers; Case-Control Studies; China; Erythrocytes; Female; Folic Acid; Heart Defects, Congenital; Humans; Mendelian Randomization Analysis; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Prospective Studies | 2022 |
Association between maternal smoke exposure and congenital heart defects from a case-control study in China.
Topics: Case-Control Studies; China; Female; Folic Acid; Heart Defects, Congenital; Humans; Male; Maternal Exposure; Nicotiana; Risk Factors; Smoke; Tobacco Smoke Pollution | 2022 |
Synergistic protective effects of folic acid and resveratrol against fine particulate matter-induced heart malformations in zebrafish embryos.
Topics: Animals; Antioxidants; Folic Acid; Heart Defects, Congenital; Particulate Matter; Reactive Oxygen Species; Resveratrol; Zebrafish | 2022 |
Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development.
Topics: Animals; Calcium; Embryonic Development; Female; Folic Acid; Heart; Heart Defects, Congenital; Mice; Pregnancy; Zebrafish | 2022 |
Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study.
Topics: Fetus; Folic Acid; Genotype; Heart; Heart Defects, Congenital; Humans | 2023 |
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease.
Topics: Animals; Female; Folic Acid; Heart Defects, Congenital; Humans; Mice; Myocardial Infarction; Palmitic Acid; Pregnancy; Signal Transduction | 2023 |
Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease.
Topics: Case-Control Studies; Child; Family; Female; Folic Acid; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Pregnancy | 2023 |
Risk factors for congenital heart disease: The Baby Hearts Study, a population-based case-control study.
Topics: Adult; Case-Control Studies; Diabetes, Gestational; Diet; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant; Maternal Behavior; Mental Health; Obesity; Pregnancy; Probability; Reproduction; Risk Factors; Smoking; Stress, Psychological | 2020 |
First-Trimester Maternal Folic Acid Supplementation Reduced Risks of Severe and Most Congenital Heart Diseases in Offspring: A Large Case-Control Study.
Topics: Adolescent; Adult; Case-Control Studies; China; Dietary Supplements; Drug Combinations; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Humans; Maternal Nutritional Physiological Phenomena; Nutritional Status; Pregnancy; Pregnancy Trimester, First; Protective Factors; Registries; Risk Assessment; Risk Factors; Vitamins; Young Adult | 2020 |
Maternal folic acid supplementation mediates the associations between maternal socioeconomic status and congenital heart diseases in offspring.
Topics: Case-Control Studies; China; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Risk Factors; Social Class | 2021 |
Maternal B-vitamin intake and B-vitamin supplementation during pregnancy in relation to neonatal congenital heart defects: a case-control study with propensity score matching.
Topics: Case-Control Studies; China; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant, Newborn; Pregnancy; Propensity Score; Vitamin B 12; Vitamin B Complex | 2021 |
Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring.
Topics: Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Mothers; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Factors | 2021 |
Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case-Control Study.
Topics: Case-Control Studies; Child; Diet; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Homocystinuria; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Pregnancy; Prospective Studies; Psychotic Disorders | 2021 |
Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring.
Topics: Adult; Air Pollutants; Air Pollution; Case-Control Studies; Choline; Diet Records; Eating; Female; Folic Acid; Food Analysis; Heart Defects, Congenital; Humans; Infant, Newborn; Maternal Exposure; Methionine; Nitrogen Dioxide; Odds Ratio; Pregnancy; Prenatal Nutritional Physiological Phenomena; Risk Factors; United States; Vitamin B 12; Vitamin B 6 | 2017 |
Abnormal Biomarkers of Homocysteine Metabolism in Neonates with Conotruncal Heart Defects.
Topics: Biomarkers; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Male; Metabolic Networks and Pathways | 2017 |
Folate, vitamin B12, homocysteine and polymorphisms in folate metabolizing genes in children with congenital heart disease and their mothers.
Topics: Adult; Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Heart Defects, Congenital; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Single Nucleotide; Risk Factors; Socioeconomic Factors; Vitamin B 12; Young Adult | 2017 |
Folic Acid Effect on Artemether-Induced Cardiac Anomalies in Mice Embryos.
Topics: Abnormalities, Drug-Induced; Animals; Artemether; Artemisinins; Female; Fetus; Folic Acid; Heart Defects, Congenital; Mice; Pregnancy; Pregnancy, Animal | 2017 |
Maternal folic acid supplementation and dietary folate intake and congenital heart defects.
Topics: Adult; China; Cohort Studies; Diet; Female; Folic Acid; Heart Defects, Congenital; Humans; Pregnancy | 2017 |
Non-inheritable risk factors during pregnancy for congenital heart defects in offspring: A matched case-control study.
Topics: Adult; Case-Control Studies; Causality; China; Demography; Environmental Exposure; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complications; Risk Assessment; Risk Factors; Socioeconomic Factors; Vitamin B Complex | 2018 |
[Case-control study on the association between four single nucleotide polymorphisms in folate metabolism way and the risk of congenital heart disease].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Child; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors | 2018 |
Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian People; Case-Control Studies; Child, Preschool; China; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein | 2018 |
Association Between Maternal Folic Acid Supplementation and Congenital Heart Defects in Offspring in Birth Cohorts From Denmark and Norway.
Topics: Adult; Denmark; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Heart Defects, Congenital; Humans; Incidence; Infant, Newborn; Male; Norway; Pregnancy; Prevalence; Prognosis; Prospective Studies; Registries; Vitamin B Complex; Young Adult | 2019 |
3D light-sheet assay assessing novel valproate-associated cardiotoxicity and folic acid relief in zebrafish embryogenesis.
Topics: Animals; Biological Assay; Cardiotoxicity; Diagnostic Imaging; Embryo, Nonmammalian; Embryonic Development; Folic Acid; Heart Defects, Congenital; Intravital Microscopy; Myocytes, Cardiac; Valproic Acid; Zebrafish | 2019 |
Maternal and cord blood homocysteine, vitamin B12, folate, and B-type natriuretic peptide levels at term for predicting congenital heart disease of the neonate: A case-control study.
Topics: Case-Control Studies; Female; Fetal Blood; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Natriuretic Peptide, Brain; Pregnancy; Vitamin B 12 | 2020 |
The association between periconceptional folic acid supplementation and congenital heart defects: a case-control study in China.
Topics: Adult; Case-Control Studies; China; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Preconception Care; Pregnancy; Vitamin B Complex; Young Adult | 2013 |
Maternal dietary patterns are associated with risk of neural tube and congenital heart defects.
Topics: Adult; Case-Control Studies; Diet; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Logistic Models; Neural Tube Defects; Pregnancy; United States; Young Adult | 2013 |
The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects.
Topics: Animals; Birds; Cell Differentiation; Dietary Supplements; Disease Models, Animal; Ethanol; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Heart; Heart Defects, Congenital; Homocysteine; Humans; Lithium Compounds; Maternal Exposure; Mice; Myocytes, Cardiac; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Signal Transduction; Wnt Proteins | 2013 |
Association of SNPs in genes involved in folate metabolism with the risk of congenital heart disease.
Topics: Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Methionine Sulfoxide Reductases; Methylenetetrahydrofolate Reductase (NADPH2); Microfilament Proteins; NF-E2-Related Factor 2; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors; Transcription Factors | 2013 |
Maternal Phenylketonuria International Collaborative Study revisited: evaluation of maternal nutritional risk factors besides phenylalanine for fetal congenital heart defects.
Topics: Amino Acids; Body Weight; Dietary Proteins; Female; Folic Acid; Heart Defects, Congenital; Humans; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Registries; Risk Factors; Weight Gain | 2014 |
Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid.
Topics: Alcohol-Induced Disorders; Animals; Central Nervous System Depressants; Ethanol; Folic Acid; Gastrulation; Heart; Heart Defects, Congenital; Organogenesis; Vitamin B Complex; Zebrafish | 2013 |
Risk factors in the origin of congenital left-ventricular outflow-tract obstruction defects of the heart: a population-based case-control study.
Topics: Case-Control Studies; Diabetes Mellitus; Female; Folic Acid; Heart Defects, Congenital; Humans; Hungary; Male; Maternal Welfare; Panic Disorder; Pregnancy; Pregnancy Complications; Prenatal Care; Registries; Risk Assessment; Risk Factors; Survival Analysis; Ultrasonography, Prenatal; Ventricular Outflow Obstruction | 2014 |
Annual trends in use of periconceptional folic acid and birth prevalence of major congenital malformations.
Topics: Adolescent; Adult; Congenital Abnormalities; Databases, Factual; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant, Newborn; Middle Aged; Musculoskeletal Abnormalities; Nervous System Malformations; Pregnancy; Pregnancy Outcome; Prevalence; Quebec; Registries; Treatment Outcome; Vitamin B Complex; Young Adult | 2013 |
Folic acid fortification and the birth prevalence of congenital heart defect cases in Alberta, Canada.
Topics: Alberta; Female; Folic Acid; Heart Defects, Congenital; Humans; Maternal Exposure; Prevalence | 2013 |
Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.
Topics: Adult; Bayes Theorem; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Glutamate-Cysteine Ligase; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Polymorphism, Single Nucleotide; Pregnancy; Prospective Studies; Risk Factors; Thymidylate Synthase | 2014 |
Rare de novo copy number variants in patients with congenital pulmonary atresia.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 22; DNA Copy Number Variations; Female; Folic Acid; Genetic Loci; Genome-Wide Association Study; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Oligonucleotide Array Sequence Analysis; Pulmonary Atresia; Ultrasonography; Vitamin B 12 | 2014 |
The Phosphorylation State of GSK3β Serine 9 Correlated to the Development of Valproic Acid-Associated Fetal Cardiac Teratogenicity, Fetal VPA Syndrome, Rescued by Folic Acid Administration.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Bradycardia; Cell Proliferation; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Female; Folic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart Defects, Congenital; Heart Ventricles; Male; Myocytes, Cardiac; Phosphorylation; Serine; Valproic Acid; Vitamins; Zebrafish | 2016 |
Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Child; Cystathionine beta-Synthase; Environmental Exposure; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Logistic Models; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors | 2015 |
Periconceptional Folic Acid Supplementation and Infant Risk of Congenital Heart Defects in Norway 1999-2009.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Maternal Nutritional Physiological Phenomena; Norway; Preconception Care; Pregnancy; Pregnant Women; Prospective Studies; Registries; Risk Factors; Time Factors | 2015 |
Folic acid in pregnant women associated with reduced prevalence of severe congenital heart defects in their children: a national population-based case-control study.
Topics: Adolescent; Adult; Case-Control Studies; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Heart Defects, Congenital; Heart Septal Defects, Atrial; Heart Septal Defects, Ventricular; Humans; Hungary; Pregnancy; Prenatal Care; Prevalence; Tetralogy of Fallot; Transposition of Great Vessels; Vitamin B Complex; Young Adult | 2015 |
[Correlation between offspring congenital heart disease and MTHFR 677C/T polymorphism and general status of pregnant women].
Topics: Case-Control Studies; Female; Folic Acid; Gene Frequency; Genotype; Heart Defects, Congenital; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Prevalence | 2015 |
Acute alcohol exposure during mouse gastrulation alters lipid metabolism in placental and heart development: Folate prevention.
Topics: Animals; Ethanol; Female; Folic Acid; Gastrulation; Gene Expression Regulation, Developmental; Heart; Heart Defects, Congenital; Lipid Metabolism; Mice; Placenta; Pregnancy | 2016 |
Effect of Folic Acid Food Fortification in Canada on Congenital Heart Disease Subtypes.
Topics: Adult; Birth Rate; Canada; Cohort Studies; Female; Folic Acid; Food, Fortified; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Population Surveillance; Pregnancy; Treatment Outcome | 2016 |
Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility.
Topics: Adenosine Triphosphatases; Animals; Asian People; ATPases Associated with Diverse Cellular Activities; Biomarkers; Case-Control Studies; Chi-Square Distribution; Child, Preschool; China; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital; HEK293 Cells; Heterozygote; Homozygote; Humans; Introns; Logistic Models; Male; Membrane Transport Proteins; Microtubule-Associated Proteins; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex; Protective Factors; Proteolysis; Rats; Risk Assessment; Risk Factors; RNA Interference; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Transfection | 2017 |
Molecular mechanisms of adaptation to folate deficiency.
Topics: Animals; Antineoplastic Agents; Atherosclerosis; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Heart Defects, Congenital; Humans; Hyperhomocysteinemia; Mice; Neoplasms; Neural Tube Defects | 2008 |
Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Maternal Behavior; Middle Aged; Mothers; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Pregnancy; Smoking; Young Adult | 2008 |
Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Palate; Dietary Supplements; Drug Utilization; Epilepsy; Female; Folic Acid; Follow-Up Studies; Guidelines as Topic; Heart Defects, Congenital; Humans; Hypospadias; Infant, Newborn; Male; Neural Tube Defects; Pregnancy; Prospective Studies; Registries; United Kingdom; Vitamins; Young Adult | 2009 |
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.
Topics: Animals; Apolipoprotein A-I; Dietary Supplements; Embryo Loss; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Heart Defects, Congenital; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Neural Tube Defects; Placenta; Pregnancy; Vitamin B Complex | 2009 |
Folic acid fortification and congenital heart disease.
Topics: Female; Folic Acid; Food, Fortified; Heart Defects, Congenital; Humans; Pregnancy; Prenatal Care | 2009 |
Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada.
Topics: Edible Grain; Female; Folic Acid; Follow-Up Studies; Food, Fortified; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Pregnancy; Prenatal Care; Prevalence; Quebec; Time Factors | 2009 |
Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Cell Survival; Cells, Cultured; Chick Embryo; Drug Antagonism; Embryo Loss; Ethanol; Fetal Weight; Folic Acid; Heart; Heart Defects, Congenital; In Vitro Techniques; Myocytes, Cardiac | 2009 |
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
Topics: Biological Transport; California; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; Heart Defects, Congenital; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Spinal Dysraphism | 2009 |
[Iodine and folic acid in food: prevention or paternalism?].
Topics: Animals; Cardiovascular Diseases; Female; Folic Acid; Food, Fortified; Heart Defects, Congenital; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; Iodine; Neural Tube Defects; Pregnancy; Thyroiditis, Autoimmune | 2009 |
Gene expression profiling in the fetal cardiac tissue after folate and low-dose trichloroethylene exposure.
Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; Cell Differentiation; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Gene Expression Profiling; Heart; Heart Defects, Congenital; Ion Channels; Ion Transport; Mice; Organogenesis; Pregnancy; Rats; Teratogens; Trichloroethylene; Water Pollutants, Chemical | 2010 |
Double aneuploidy (48,XXY,+21) of maternal origin in a child born to a 13-year-old mother: evaluation of the maternal folate metabolism.
Topics: Adolescent; Alleles; Aneuploidy; Brazil; Chromosomes, Human, X; Chromosomes, Human, Y; DNA Mutational Analysis; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Carrier Screening; Genotype; Heart Defects, Congenital; Homocysteine; Homozygote; Humans; Infant; Klinefelter Syndrome; Male; Meiosis; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Nondisjunction, Genetic; Polymorphism, Genetic; Pregnancy; Pregnancy in Adolescence; Sex Chromosome Aberrations; Trisomy | 2009 |
Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands.
Topics: Adolescent; Adult; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Middle Aged; Netherlands; Preconception Care; Pregnancy; Registries; Risk Factors; Vitamin B Complex; Young Adult | 2010 |
[Study of correlationship between congenital heart disease and 5, 10-methylenetetra hydrofolate reductase gene's polymorphism or folacin intakes].
Topics: Case-Control Studies; Child, Preschool; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Risk Factors | 2009 |
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
Topics: Cohort Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Phenotype; Polymorphism, Single Nucleotide; Risk Factors | 2008 |
Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.
Topics: Child; Female; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Linear Models; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2010 |
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate.
Topics: Animals; beta Catenin; Chick Embryo; Disease Models, Animal; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Folic Acid; Heart; Heart Defects, Congenital; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Pregnancy; Random Allocation; Ultrasonography, Doppler; Wnt Proteins | 2010 |
Maternal folate-related gene environment interactions and congenital heart defects.
Topics: Adult; Alcohol Drinking; Betaine-Homocysteine S-Methyltransferase; Case-Control Studies; Female; Folic Acid; Heart Defects, Congenital; Humans; Life Style; Methylenetetrahydrofolate Reductase (NADPH2); Obesity; Polymorphism, Single Nucleotide; Pregnancy; Smoking; Transcobalamins | 2010 |
Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome.
Topics: Black People; Case-Control Studies; Causality; Chromosomes, Human, Pair 21; Comorbidity; Down Syndrome; Folic Acid; Genetic Association Studies; Genetic Variation; Genotype; Heart Defects, Congenital; Heart Septal Defects; Humans; Incidence; Polymorphism, Single Nucleotide; White People | 2010 |
Congenital heart defects and biomarkers of methylation in children: a case-control study.
Topics: Biomarkers; Case-Control Studies; Child, Preschool; Down Syndrome; Female; Folic Acid; Heart Defects, Congenital; Humans; Hyperhomocysteinemia; Infant; Male; Methylation; Netherlands; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Vitamin B 12 | 2011 |
General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Maternal Exposure; Polymorphism, Genetic; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Surveys and Questionnaires; Vitamin B Complex | 2011 |
A derangement of the maternal lipid profile is associated with an elevated risk of congenital heart disease in the offspring.
Topics: Adult; Apolipoproteins B; Body Mass Index; Case-Control Studies; Child; Cholesterol, LDL; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Hyperglycemia; Hyperhomocysteinemia; Logistic Models; Multivariate Analysis; Odds Ratio; Pregnancy; Pregnancy Complications, Cardiovascular; Risk Factors; Young Adult | 2012 |
High intake of folic acid disrupts embryonic development in mice.
Topics: Animals; Congenital Abnormalities; Dietary Supplements; Embryo Loss; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Heart Defects, Congenital; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Pregnancy | 2011 |
NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.
Topics: Adult; Arylamine N-Acetyltransferase; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Isoenzymes; Male; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Risk Factors; Thymidylate Synthase | 2011 |
Maternal DNA hypomethylation and congenital heart defects.
Topics: Case-Control Studies; DNA; DNA Methylation; Eating; Female; Folic Acid; Gene Expression Regulation, Developmental; Heart Defects, Congenital; Humans; Long Interspersed Nucleotide Elements; Mothers; Polymerase Chain Reaction; Pregnancy; Risk Factors | 2011 |
Congenital heart defects and maternal genetic, metabolic, and lifestyle factors.
Topics: Adult; Arkansas; Biomarkers; Case-Control Studies; Female; Folic Acid; Genetic Variation; Genotype; Glutathione Disulfide; Heart Defects, Congenital; Humans; Life Style; Linear Models; Logistic Models; Methionine; Multivariate Analysis; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors | 2011 |
Evaluation of heterogeneity in the association between congenital heart defects and variants of folate metabolism genes: conotruncal and left-sided cardiac defects.
Topics: Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Male; Risk Factors | 2011 |
Methylenetetrahydrofolate reductase gene 677CT polymorphism and isolated congenital heart disease in a Mexican population.
Topics: Adolescent; Adult; Alleles; Child; Child, Preschool; DNA; Female; Folic Acid; Gene Frequency; Heart Defects, Congenital; Homocysteine; Humans; Infant; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy; Prenatal Care; Young Adult | 2012 |
Risk of congenital heart defects is influenced by genetic variation in folate metabolism.
Topics: Aortic Valve Stenosis; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein | 2013 |
Gene variants in the folate-mediated one-carbon metabolism (FOCM) pathway as risk factors for conotruncal heart defects.
Topics: Carbon; Female; Folic Acid; Genotype; Heart Defects, Congenital; Hispanic or Latino; Humans; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Genetic; Risk Factors | 2012 |
Polymorphism 677C → T MTHFR gene in Mexican mothers of children with complex congenital heart disease.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mothers; Polymorphism, Genetic; Pregnancy; Risk Factors; Surveys and Questionnaires | 2013 |
Lack of association between folate receptor autoantibodies and conotruncal congenital heart defects.
Topics: Adult; Autoantibodies; Case-Control Studies; Female; Fetal Diseases; Folate Receptors, GPI-Anchored; Folic Acid; Gestational Age; Heart Defects, Congenital; Humans; Immunoglobulin G; Immunoglobulin M; Incidence; Neural Tube Defects; Pregnancy; Prognosis; Reference Values; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Statistics, Nonparametric | 2013 |
Associations between maternal genotypes and metabolites implicated in congenital heart defects.
Topics: Adult; Asymptomatic Diseases; Carbon-Nitrogen Ligases; Case-Control Studies; Catalase; DNA (Cytosine-5-)-Methyltransferases; DNA Modification Methylases; DNA Repair Enzymes; Female; Folic Acid; Genotype; Glutathione; Glutathione Peroxidase; Heart Defects, Congenital; Homocysteine; Humans; Life Style; Male; Methionine; Methionine Adenosyltransferase; Polymorphism, Single Nucleotide; Risk; Tumor Suppressor Proteins | 2012 |
Teratogenic effects of diabetic conditions in chick heart in ovo and in micromass culture may be prevented by addition of vitamin C and folic acid.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Ascorbic Acid; Cell Survival; Cells, Cultured; Chick Embryo; Diabetes Complications; Folic Acid; Glucose; Heart; Heart Defects, Congenital; Teratogens; Vitamins | 2013 |
Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps.
Topics: Case-Control Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Forecasting; Heart Defects, Congenital; Humans; Infant, Newborn; Maternal-Fetal Exchange; Preconception Care; Pregnancy; Prenatal Care; Randomized Controlled Trials as Topic; Trace Elements; Vitamins | 2003 |
ABNORMALITIES OF PULMONARY AND OTHER VESSELS IN RAT FETUSES FROM MATERNAL PTEROYLGLUTAMIC ACID DEFICIENCY.
Topics: Animals; Coronary Vessel Anomalies; Female; Fetus; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Pulmonary Valve Stenosis; Rats; Research; Vitamin B Deficiency | 1963 |
Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects.
Topics: California; Carrier Proteins; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Variation; Genotype; Heart Defects, Congenital; Humans; Infant; Membrane Proteins; Membrane Transport Proteins; Pregnancy; Risk Factors | 2003 |
[Relations of methionine synthase gene variation with congenital heart disease].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glutathione; Heart Defects, Congenital; Heart Septal Defects; Homocysteine; Humans; Infant; Male; Polymorphism, Genetic; Vitamin B 12 | 2004 |
[Active screening for genetic pathology in newborns. I. Registration of congenital abnormalities].
Topics: Bulgaria; Congenital Abnormalities; Down Syndrome; Folic Acid; Genetic Testing; Heart Defects, Congenital; Humans; Incidence; Infant, Newborn; Neural Tube Defects; Registries; Retrospective Studies | 2004 |
Developmental consequences of abnormal folate transport during murine heart morphogenesis.
Topics: Animals; Carrier Proteins; Cell Division; DNA-Binding Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Heart; Heart Defects, Congenital; Mice; Mice, Knockout; Myocytes, Cardiac; Paired Box Transcription Factors; PAX3 Transcription Factor; Receptors, Cell Surface; Telomerase; Transcription Factors | 2004 |
[Study of serum Hcy and polymorphisms of Hcy metabolic enzymes in 192 families affected by congenital heart disease].
Topics: Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Vitamin B 12 | 2005 |
Relationship between polymorphism of methylenetetrahydrofolate dehydrogenase and congenital heart defect.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; China; Female; Folic Acid; Gene Frequency; Genotype; Heart Defects, Congenital; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mutation; Polymorphism, Genetic | 2005 |
Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene.
Topics: Alleles; Folic Acid; Haplotypes; Heart Defects, Congenital; Humans; Infant, Newborn; Linkage Disequilibrium; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2006 |
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
Topics: Animals; Diet; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Pregnancy | 2005 |
Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China.
Topics: Case-Control Studies; China; Cleft Lip; Cleft Palate; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Membrane Transport Proteins; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk; Vitamin B Complex | 2006 |
Congenital heart defects and maternal biomarkers of oxidative stress.
Topics: Adult; Arkansas; Biomarkers; Case-Control Studies; Dipeptides; Female; Folic Acid; Glutathione; Glutathione Disulfide; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Life Style; Oxidative Stress; Pregnancy; Pregnancy Complications; Registries; Risk Factors; S-Adenosylhomocysteine; Vitamin B 6 | 2005 |
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Preconception Care; Risk Factors | 2006 |
[Relations between serum homocysteine and folic acid levels with congenital heart disease].
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Infant; Male; Parents; Vitamin B 12; Young Adult | 2005 |
Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart.
Topics: Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Proliferation; Diet; Embryonic Development; Female; Folic Acid; Folic Acid Deficiency; Genotype; Heart Defects, Congenital; Hematinics; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Pregnancy | 2006 |
Folate intake and the primary prevention of non-neural birth defects.
Topics: Case-Control Studies; Confidence Intervals; Congenital Abnormalities; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Heart Defects, Congenital; Humans; Limb Deformities, Congenital; Maternal-Fetal Exchange; Mouth Abnormalities; Neural Tube Defects; Odds Ratio; Preconception Care; Pregnancy; Pregnancy Trimester, First; Prenatal Care; Primary Prevention; Urinary Tract; Western Australia | 2006 |
Recent advances in the prevention of congenital heart disease.
Topics: Animals; Disease Models, Animal; Folic Acid; Forecasting; Heart Defects, Congenital; Humans; Infant, Newborn; Polymorphism, Genetic; Risk Factors; Vitamin B Complex | 2006 |
Can folic acid protect against congenital heart defects in Down syndrome?
Topics: Dietary Supplements; Down Syndrome; Female; Folic Acid; Food, Fortified; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Trimester, First; Retrospective Studies | 2006 |
Dietary intake of B-vitamins in mothers born a child with a congenital heart defect.
Topics: Adult; Case-Control Studies; Dietary Proteins; Educational Status; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Logistic Models; Maternal Nutritional Physiological Phenomena; Nutritional Requirements; Nutritional Status; Pregnancy; Pregnancy Complications; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B Complex | 2006 |
Homocysteine concentrations and molecular analysis in patients with congenital heart defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Carbon-Nitrogen Ligases; Child, Preschool; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Heart Defects, Congenital; Homocysteine; Humans; Male; Mutation; Vitamin B 12 | 2007 |
Non-optimal maturation of the oocyte, maternal MTHFR polymorphisms, periconceptional folate, and decrease of congenital heart defects.
Topics: Dietary Supplements; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Heterozygote; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oocytes; Polymorphism, Genetic; Preconception Care | 2007 |
Congenital heart defects in Canadian Inuit: is more folic acid making a difference?
Topics: Adolescent; Adult; Canada; Case-Control Studies; Female; Folic Acid; Food, Fortified; Heart Defects, Congenital; Humans; Inuit; Male; Middle Aged; Risk Factors | 2007 |
Socioeconomic status in relation to selected birth defects in a large multicentered US case-control study.
Topics: Adult; Age Distribution; Alcohol Drinking; Case-Control Studies; Causality; Congenital Abnormalities; Craniofacial Abnormalities; Dietary Supplements; Fathers; Female; Folic Acid; Gravidity; Heart Defects, Congenital; Humans; Male; Mothers; Neural Tube Defects; Obesity; Odds Ratio; Phenotype; Pregnancy; Racial Groups; Socioeconomic Factors; United States | 2008 |
[Study on the correlation of serum folate and red blood cell folate level with birth defects and unexplained recurrent pregnancy loss].
Topics: Abortion, Spontaneous; Adult; Congenital Abnormalities; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Humans; Infant, Newborn; Nutritional Requirements; Pregnancy; Pregnancy Outcome; Vitamin B 12 | 2007 |
Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs.
Topics: Adult; Carbon-Nitrogen Ligases; Case-Control Studies; Female; Folic Acid; Genotype; Heart Defects, Congenital; Humans; Infant; Male; Netherlands; Riboflavin; Risk Factors | 2008 |
Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid.
Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; Folic Acid; Gastrula; Heart Defects, Congenital; Homocysteine; Mice; Neural Tube Defects; Teratogens | 1996 |
Preconceptional folate intake and malformations of the cardiac outflow tract. Baltimore-Washington Infant Study Group.
Topics: Dietary Supplements; Female; Folic Acid; Heart Defects, Congenital; Humans; Infant, Newborn; Logistic Models; Odds Ratio; Preconception Care; Pregnancy; Transposition of Great Vessels | 1998 |
Tapping the savings from vitamin-based prevention.
Topics: Coronary Disease; Cost Savings; Cost-Benefit Analysis; Female; Folic Acid; Heart Defects, Congenital; Hospitalization; Humans; Infant, Low Birth Weight; Infant, Newborn; Managed Care Programs; Outcome Assessment, Health Care; Pregnancy; Pregnancy Outcome; Prenatal Care; Spinal Dysraphism; United States; Vitamins; Zinc | 1998 |
Folic acid antagonists during pregnancy and the risk of birth defects.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Cleft Lip; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Heart Defects, Congenital; Humans; Logistic Models; Pregnancy; Urinary Tract; Vitamins | 2000 |
[Effects of homocysteine on cardiovascular development in early chicken embryo].
Topics: Animals; Cardiovascular System; Chick Embryo; Folic Acid; Heart Defects, Congenital; Homocysteine; Vitamin B 12 | 1999 |
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model.
Topics: Animals; Body Weight; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Male; Mice; Mice, Inbred ICR; Neural Tube Defects; Pregnancy | 2002 |
Folic acid deficiency in infants and children with heart disease.
Topics: Adolescent; Cardiomegaly; Child; Child, Preschool; Diet; Diuretics; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Growth; Heart Defects, Congenital; Heart Failure; Hemoglobinometry; Histidine; Humans; Infant; Male; Rheumatic Heart Disease; Social Class | 1973 |