fluvoxamine has been researched along with Schizotypal-Personality-Disorder* in 3 studies
3 other study(ies) available for fluvoxamine and Schizotypal-Personality-Disorder
Article | Year |
---|---|
Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial.
A few studies have tried antipsychotic augmentation in obsessive-compulsive disorder (OCD) patients who are non-responders to selective serotonin reuptake inhibitors. The aim of this study was to investigate the efficacy and tolerability of olanzapine addition to fluvoxamine-refractory OCD patients and to assess if a comorbid chronic tic disorder or a concomitant schizotypal personality disorder was associated with response. Twenty-three OCD non-responders to a 6-month, open-label trial with fluvoxamine (300 mg/day) entered a 3-month open-label trial of augmentation with olanzapine (5 mg/day). OC symptom change was measured with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Clinical Global Impression (CGI) scale. Differences between responders and non-responders were assessed with regard to age, sex, duration of illness, baseline Y-BOCS score, and comorbidity with chronic tic disorders or schizotypal personality disorder. A significant decrease of mean Y-BOCS score between pre- and post-treatment (26. 8+/-3.0 vs. 18.9+/-5.9) was found at endpoint. Ten patients (43.5%) were rated as responders. The most common side effects were mild to moderate weight gain and sedation. In our sample, three patients (13. 04%) had a chronic motor tic disorder, and four (17.39%) had a codiagnosis of schizotypal personality disorder. Concomitant schizotypal personality disorder was the only factor significantly associated with response. It appears that augmentation of olanzapine in fluvoxamine-refractory OCD may be effective in a large number of patients, including those with comorbid schizotypal personality disorder. Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Comorbidity; Drug Therapy, Combination; Female; Fluvoxamine; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Olanzapine; Pirenzepine; Psychiatric Status Rating Scales; Schizotypal Personality Disorder; Tic Disorders; Treatment Outcome | 2000 |
Seizures induced by combined levomepromazine-fluvoxamine treatment.
We report a case of combined levomepromazine-fluvoxamine treatment-induced seizures. It seems that combined treatment of fluvoxamine with phenothiazines may possess proconvulsive activity. Topics: Adult; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Fluvoxamine; Humans; Methotrimeprazine; Obsessive-Compulsive Disorder; Schizotypal Personality Disorder | 1993 |
Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder.
Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such patients. Topics: Adult; Antipsychotic Agents; Drug Therapy, Combination; Female; Fluvoxamine; Humans; Lithium; Male; Obsessive-Compulsive Disorder; Oximes; Schizotypal Personality Disorder; Serotonin Antagonists; Tic Disorders | 1990 |