fluvoxamine and Diabetic-Nephropathies

Seven Japanese patients on maintenance hemodialysis who were comorbid with mild depression were medicated with 50 mg/day fluvoxamine maleate for 28 days. Effectiveness was obtained in four out of seven patients (57%). The plasma fluvoxamine concentrations were examined in three patients. The plasma fuvoxamine concentration decreased by 22% by hemodialysis. There is a tendency for the dialyzed rate of fluvoxamine to become lower if the plasma albumin concentration is higher. The half-life of fluvoxamine was possibly shortened more in the patient with hypoalbuminaemia. The plasma fluvoxamine concentration reached a steady state 8 days after the start of medication and thereafter. The time required to reach steady state was lengthened when compared with the results in normal Japanese volunteers.

Topics: Antidepressive Agents, Second-Generation; Biological Availability; Depressive Disorder; Diabetic Nephropathies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluvoxamine; Half-Life; Humans; Japan; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Personality Inventory; Renal Dialysis; Treatment Outcome