fluticasone-propionate--salmeterol-xinafoate-drug-combination and Voice-Disorders

Voice problems are reported as a frequent side effect of inhaled combination (IC) treatments. The purpose of this experimental study was to investigate whether IC treatments are detrimental to phonation. We hypothesized that IC treatment would significantly increase phonation threshold pressure (PTP) and perceived phonatory effort (PPE), whereas sham treatment would not.. Fourteen healthy adults participated in a repeated-measures design in which they received IC and sham treatments in counterbalanced order. PTP and PPE were measured prior to treatments, immediately following treatments, and at 1 and 2 hr following treatments.. IC treatment increased PTP, but sham treatment did not. The increase in PTP was maintained for a 2 hr period following administration. PPE ratings were not significantly correlated with PTP.. IC treatments can have acute, adverse effects on phonation. Detrimental phonatory effects were elicited in participants with no self-reported voice problems. IC treatments are being increasingly prescribed across the lifespan. The current data increase our understanding of the nature of phonatory deterioration associated with IC treatment and lay the groundwork for increased research effort to develop IC treatments that effectively control respiratory disease while minimizing an adverse effect on phonation.

Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Androstadienes; Asthma; Drug Combinations; Female; Fluticasone-Salmeterol Drug Combination; Glucocorticoids; Humans; Male; Phonation; Pressure; Time Factors; Voice Disorders; Young Adult

This study examined the effects of a combination corticosteroid plus long-acting beta. Repeated measures analysis of variance indicated significant differences between the experimental and control groups (p < 0.05). Mean PTP and PTF values were higher (worse) for rabbits that received Advair HFA™.. Following 8-week exposure to ICs, rabbit larynges required greater air pressure and flow to initiate phonation. Because even modest phonation onset differences can have a meaningful clinical impact on voice function, these findings suggest that LABA ICs may put patients at risk for voice disorders. Furthermore, these voice disorders may occur within a relatively short timeframe. The results from this study have important clinical implications for voice care in those who use ICs.. NA Laryngoscope, 133:2680-2686, 2023.

Topics: Administration, Inhalation; Adrenal Cortex Hormones; Animals; Fluticasone-Salmeterol Drug Combination; Male; Nebulizers and Vaporizers; Phonation; Rabbits; Voice Disorders