fluticasone-propionate--salmeterol-xinafoate-drug-combination and HIV-Infections

fluticasone-propionate--salmeterol-xinafoate-drug-combination has been researched along with HIV-Infections* in 2 studies

Other Studies

2 other study(ies) available for fluticasone-propionate--salmeterol-xinafoate-drug-combination and HIV-Infections

ArticleYear
[Cushing's syndrome during HIV treatment: pharmacological interaction during use of ritonavir].
    Nederlands tijdschrift voor geneeskunde, 2013, Volume: 157, Issue:14

    Physicians are not always aware that locally administered glucocorticoids can cause systemic toxicity. This risk is greatly enhanced in the case of pharmacological interactions. We present two cases of HIV-infected patients who developed Cushing-like symptoms as a result of a pharmacological interaction. Their antiretroviral treatment regimen consisted of atazanavir, ritonavir, tenofovir and emtricitabine. One patient received salmeterol/fluticasone inhalations for asthmatic bronchitis. The other was treated with intra-articular triamcinolonacetonide injections for ongoing shoulder complaints. Ritonavir exhibits strong inhibition of hepatic enzyme CYP 3A4, which is part of the major metabolic pathway of most glucocorticoids. As a result of this interaction even locally administered glucocorticoids can cause symptoms of overdose, e.g. Cushing-like symptoms. Beclomethasone is a safe alternative for inhaled glucocorticoids as it is not metabolized by CYP 3A4. There is no substitute for intra-articular administration of triamcinolonacetonide. Depending on necessity of the administration of the drug, changing ritonavir-containing antiretroviral therapy to a non-interacting compound, e.g., an integrase inhibitor, is an option.

    Topics: Adult; Albuterol; Androstadienes; Asthma; Bronchodilator Agents; Cushing Syndrome; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Drug Interactions; Fluticasone-Salmeterol Drug Combination; Glucocorticoids; HIV Infections; HIV Protease Inhibitors; Humans; Male; Ritonavir

2013
[Iatrogenic Cushing syndrome in an HIV-infected female patient: be careful about interaction inhaled corticosteroids-ritonavir!].
    Presse medicale (Paris, France : 1983), 2008, Volume: 37, Issue:12

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Albuterol; Androstadienes; Cushing Syndrome; Drug Combinations; Drug Interactions; Female; Fluticasone-Salmeterol Drug Combination; HIV Infections; HIV Protease Inhibitors; Humans; Iatrogenic Disease; Ritonavir

2008