flutamide has been researched along with Seizures in 5 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Latency and incidence of a clonic seizure were recorded." | 5.32 | Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003) |
| " 3alpha-Androstanediol protected mice against seizures induced by GABAA receptor antagonists pentylenetetrazol, picrotoxin, and beta-carboline ester in a dose-dependent fashion." | 3.72 | Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol. ( Reddy, DS, 2004) |
| "Testosterone modulates seizure susceptibility, but the underlying mechanisms are obscure." | 1.36 | The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors. ( Jian, K; Reddy, DS, 2010) |
| "Actions at ERbeta may underlie some antiseizure effects of T's metabolites." | 1.35 | Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta. ( Frye, CA; Rhodes, M; Ryan, A, 2009) |
| "Latency and incidence of a clonic seizure were recorded." | 1.32 | Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frye, CA | 2 |
| Ryan, A | 1 |
| Rhodes, M | 1 |
| Reddy, DS | 2 |
| Jian, K | 1 |
| Ahmadiani, A | 1 |
| Mandgary, A | 1 |
| Sayyah, M | 1 |
1 review available for flutamide and Seizures
| Article | Year |
|---|---|
Effects and mechanisms of progestogens and androgens in ictal activity.
Topics: Androgen Antagonists; Androgens; Animals; Anticonvulsants; Disease Models, Animal; Female; Flutamide | 2010 |
4 other studies available for flutamide and Seizures
| Article | Year |
|---|---|
Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta.
Topics: Analysis of Variance; Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Disease | 2009 |
The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors.
Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; CA1 Region, Hippocampal; Data Interpretation, S | 2010 |
Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug In | 2003 |
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.
Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Carbolines; Convulsants; Dose- | 2004 |