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flutamide and Seizures

flutamide has been researched along with Seizures in 5 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Latency and incidence of a clonic seizure were recorded."5.32Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003)
" 3alpha-Androstanediol protected mice against seizures induced by GABAA receptor antagonists pentylenetetrazol, picrotoxin, and beta-carboline ester in a dose-dependent fashion."3.72Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol. ( Reddy, DS, 2004)
"Testosterone modulates seizure susceptibility, but the underlying mechanisms are obscure."1.36The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors. ( Jian, K; Reddy, DS, 2010)
"Actions at ERbeta may underlie some antiseizure effects of T's metabolites."1.35Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta. ( Frye, CA; Rhodes, M; Ryan, A, 2009)
"Latency and incidence of a clonic seizure were recorded."1.32Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Frye, CA2
Ryan, A1
Rhodes, M1
Reddy, DS2
Jian, K1
Ahmadiani, A1
Mandgary, A1
Sayyah, M1

Reviews

1 review available for flutamide and Seizures

ArticleYear
Effects and mechanisms of progestogens and androgens in ictal activity.
    Epilepsia, 2010, Volume: 51 Suppl 3

    Topics: Androgen Antagonists; Androgens; Animals; Anticonvulsants; Disease Models, Animal; Female; Flutamide

2010

Other Studies

4 other studies available for flutamide and Seizures

ArticleYear
Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta.
    Epilepsy & behavior : E&B, 2009, Volume: 16, Issue:3

    Topics: Analysis of Variance; Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Disease

2009
The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors.
    The Journal of pharmacology and experimental therapeutics, 2010, Sep-01, Volume: 334, Issue:3

    Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; CA1 Region, Hippocampal; Data Interpretation, S

2010
Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors.
    Epilepsia, 2003, Volume: 44, Issue:5

    Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug In

2003
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.
    Neuroreport, 2004, Mar-01, Volume: 15, Issue:3

    Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Carbolines; Convulsants; Dose-

2004