flutamide has been researched along with Prostatic Intraepithelial Neoplasia in 10 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-grade prostatic intraepithelial neoplasia (HGPIN) appears to represent an ideal target for chemoprevention of prostate cancer (PCa)." | 6.73 | Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia. ( Wenlu, S; Zhigang, Z, 2008) |
| "High-grade prostatic intraepithelial neoplasia (HGPIN) is believed to be a precursor for prostatic adenocarcinoma." | 5.31 | Chemoprevention for prostatic carcinoma: The role of flutamide in patients with prostatic intraepithelial neoplasia. ( Alberts, SR; Blute, ML, 2001) |
| " A pilot study was undertaken to test the efficacy of flutamide (an antiandrogen) in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model of prostate cancer." | 3.70 | Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model. ( Greenberg, N; Kuliyev, E; Raghow, S; Steakley, M; Steiner, MS, 2000) |
| "High-grade prostatic intraepithelial neoplasia (HGPIN) appears to represent an ideal target for chemoprevention of prostate cancer (PCa)." | 2.73 | Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia. ( Wenlu, S; Zhigang, Z, 2008) |
| "Patient data related to prostatic intraepithelial neoplasia were analyzed." | 2.69 | Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance. ( Balaji, KC; Bastar, A; Fair, WR; Rabbani, F; Tsai, H, 1999) |
| "Oxidative stress plays a role in prostate cancer (PrCa) initiation and development." | 1.37 | Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage. ( Boque, N; Calvo, A; Campion, J; Catena, R; Endermann, T; Gonzalez-Moreno, O; Milagro, F; Redrado, M; Saito, Y; Schomburg, L; Takahashi, K, 2011) |
| "High-grade prostatic intraepithelial neoplasia (HGPIN) is believed to be a precursor for prostatic adenocarcinoma." | 1.31 | Chemoprevention for prostatic carcinoma: The role of flutamide in patients with prostatic intraepithelial neoplasia. ( Alberts, SR; Blute, ML, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonzalez-Moreno, O | 1 |
| Boque, N | 1 |
| Redrado, M | 1 |
| Milagro, F | 1 |
| Campion, J | 1 |
| Endermann, T | 1 |
| Takahashi, K | 1 |
| Saito, Y | 1 |
| Catena, R | 1 |
| Schomburg, L | 1 |
| Calvo, A | 1 |
| Cho, YM | 1 |
| Takahashi, S | 1 |
| Asamoto, M | 1 |
| Suzuki, S | 1 |
| Tang, M | 1 |
| Shirai, T | 1 |
| Zhigang, Z | 1 |
| Wenlu, S | 1 |
| Têtu, B | 2 |
| Wheeler, TM | 1 |
| Balaji, KC | 1 |
| Rabbani, F | 1 |
| Tsai, H | 1 |
| Bastar, A | 1 |
| Fair, WR | 1 |
| van der Kwast, TH | 1 |
| Labrie, F | 1 |
| Raghow, S | 1 |
| Kuliyev, E | 1 |
| Steakley, M | 1 |
| Greenberg, N | 1 |
| Steiner, MS | 1 |
| del Vecchio, MT | 1 |
| Tripodi, SA | 1 |
| Arcuri, F | 1 |
| Pergola, L | 1 |
| Hako, L | 1 |
| Vatti, R | 1 |
| Cintorino, M | 1 |
| Alberts, SR | 1 |
| Blute, ML | 1 |
1 review available for flutamide and Prostatic Intraepithelial Neoplasia
| Article | Year |
|---|---|
Influence of irradiation and androgen ablation on prostatic intraepithelial neoplasia.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Flutamide; Gonadot | 1996 |
4 trials available for flutamide and Prostatic Intraepithelial Neoplasia
| Article | Year |
|---|---|
Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia.
Topics: Aged; Aged, 80 and over; Antigens, Neoplasm; Antineoplastic Agents, Hormonal; Double-Blind Method; F | 2008 |
Adjuvant hormonotherapy in patients with clinically-localized prostate cancer treated by radical prostatectomy: pathological results.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocol | 1994 |
Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance.
Topics: Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up Studies; Humans; Leupr | 1999 |
Persistence of high-grade prostatic intra-epithelial neoplasia under combined androgen blockade therapy.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Cell Nucleus; Cohort Studies; Cytoplasm; Flut | 1999 |
5 other studies available for flutamide and Prostatic Intraepithelial Neoplasia
| Article | Year |
|---|---|
Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage.
Topics: Androgen Antagonists; Carcinoma; Cell Line, Tumor; Cell Transformation, Neoplastic; Down-Regulation; | 2011 |
Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Animals, Genetically Modified; Antigens, Viral, Tumor | 2007 |
Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Anticarcinogenic Agents; Blotting, Western; Crosses, | 2000 |
Macrophage migration inhibitory factor in prostatic adenocarcinoma: correlation with tumor grading and combination endocrine treatment-related changes.
Topics: Adenocarcinoma; Aged; Androgen Antagonists; Androgens; Antineoplastic Agents, Hormonal; Antineoplast | 2000 |
Chemoprevention for prostatic carcinoma: The role of flutamide in patients with prostatic intraepithelial neoplasia.
Topics: Age Factors; Androgen Antagonists; Antineoplastic Agents, Hormonal; Clinical Trials, Phase II as Top | 2001 |