flutamide has been researched along with Pregnancy in 203 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, we have found that flutamide-induced androgen deficiency altered progesterone production in the porcine corpus luteum (CL) during mid- and late pregnancy." | 9.19 | Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency. ( Ciereszko, RE; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech, I, 2014) |
| " Female Sprague-Dawley rats were administrated flutamide during late pregnancy to induce a model of cryptorchidism in male offspring." | 7.91 | Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Peng, J; Shen, L; Tao, X; Timashev, P; Wei, G; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2019) |
| "Choose 7-week-old ICR mice, female mice were randomly divided into experimental group and control group after pregnancy, thenflutamide was orally administered to pregnant mice with dose 300 mg/( kg·d) during gestation days 12-18, while the control group was treated with equal volume of soybean oil." | 7.88 | [Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring]. ( Wen, K; Yang, J; Zhou, X; Zhu, Y, 2018) |
| "Pregnant pigs were injected daily with antiandrogen flutamide, at a dose of 50 mg/kg body weight at different stages of pregnancy: between gestational days 83-89 (90 dpc) and 101-107 (108 dpc)." | 7.85 | The impact of antiandrogen flutamide on the hypoxia inducible factor 1a and vascular endothelial growth factor A gene and protein expression in the pig placenta during late pregnancy. ( Czaja, E; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech-Rojkiewicz, I, 2017) |
| "This study examined whether flutamide-induced androgen deficiency during mid- and late pregnancy in pigs affected luteal expression of adherens junction protein, β-catenin, and its interactions with E-cadherin." | 7.81 | Flutamide alters β-catenin expression and distribution, and its interactions with E-cadherin in the porcine corpus luteum of mid- and late pregnancy. ( Grzesiak, M; Janik, ME; Knapczyk-Stwora, K; Mitan, A; Slomczynska, M, 2015) |
| "The aim of this study was to determine the immunolocalization and expression of the androgen receptor (AR) in the pig placenta and umbilical cord during pregnancy following exposure to flutamide, a non-steroidal antiandrogen, at its various stages." | 7.79 | Influence of the antiandrogen flutamide on the androgen receptor gene expression in the placenta and umbilical cord during pregnancy in the pig. ( Durlej-Grzesiak, M; Słomczyńska, M; Wieciech, I, 2013) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 7.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 7.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology." | 7.72 | [A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004) |
| "Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients." | 5.51 | Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy. ( Gong, H; Kuang, H; Li, Y; Ling, Y; Liu, H; Qiao, B; Wu, W; Xu, J; Yang, B; Yu, D, 2019) |
| "Flutamide treatment caused fluctuations in Cx43 expression especially before parturition." | 5.40 | Influence of the antiandrogen flutamide on connexin 43 (Cx43) gene and protein expression in the porcine placenta and uterus during pregnancy. ( Grzesiak, M; Knapczyk-Stwora, K; Pytlik, A; Słomczynska, M; Wieciech, I, 2014) |
| "Recently, we have found that flutamide-induced androgen deficiency altered progesterone production in the porcine corpus luteum (CL) during mid- and late pregnancy." | 5.19 | Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency. ( Ciereszko, RE; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech, I, 2014) |
| " Exposure to flutamide during pregnancy will also cause abnormalities in some male offspring reproductive organs such as cryptorchidism." | 3.96 | Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide. ( Fu, H; Wen, K; Yan, Z; Yu, H; Zhang, Y; Zhou, X; Zhu, J; Zhu, Y, 2020) |
| " Female Sprague-Dawley rats were administrated flutamide during late pregnancy to induce a model of cryptorchidism in male offspring." | 3.91 | Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Peng, J; Shen, L; Tao, X; Timashev, P; Wei, G; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2019) |
| " The role of sodium acetate on cardiac uric acid (UA) production and glucose-6-phosphate dehydrogenase (G6PD)-dependent antioxidant defense in pregnancy is not known." | 3.88 | Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats. ( Areola, ED; Badmus, OO; Olatunji, LA, 2018) |
| "Choose 7-week-old ICR mice, female mice were randomly divided into experimental group and control group after pregnancy, thenflutamide was orally administered to pregnant mice with dose 300 mg/( kg·d) during gestation days 12-18, while the control group was treated with equal volume of soybean oil." | 3.88 | [Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring]. ( Wen, K; Yang, J; Zhou, X; Zhu, Y, 2018) |
| " This study tested whether 1) in utero cotreatment of prenatally T-treated sheep with androgen antagonist (flutamide) or insulin sensitizer (rosiglitazone) prevents juvenile insulin resistance and adult changes in adipocyte size; and 2) visceral adiposity and insulin sensitivity are both unaltered during early adulthood, confirming the predicted developmental trajectory in this animal model." | 3.83 | Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. ( Beckett, E; Cardoso, RC; Chazenbalk, G; Dumesic, D; Keller, E; Madrigal, V; Moeller, J; Padmanabhan, V; Pease, A; Veiga-Lopez, A, 2016) |
| "During days 12-15 of pregnancy in rats, luteal E2 was inhibited by way of daily oral administration of anastrozole (AI), a selective non-steroidal aromatase inhibitor, and experiments were also performed with E2 replacement i." | 3.83 | Analysis of 17β-estradiol (E2) role in the regulation of corpus luteum function in pregnant rats: Involvement of IGFBP5 in the E2-mediated actions. ( Asaithambi, K; Jayaram, P; Medhamurthy, R; Tripathy, S, 2016) |
| "We determined whether androgen deficiency induced by flutamide treatment during mid- and late pregnancy affects the functions of the porcine corpus luteum (CL)." | 3.80 | Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum. ( Ciereszko, RE; Golas, A; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech, I, 2014) |
| "Time-mated Sprague-Dawley female rats were injected subcutaneously with flutamide (75 mg/kg in sunflower oil) on days 16 to 19 of pregnancy." | 3.75 | The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development. ( Balic, A; Buraundi, S; Farmer, P; Hutson, J; Nation, T; Newgreen, D; Southwell, B, 2009) |
| "The incidence of hypospadias increased with the dose of flutamide (0, 29." | 3.73 | [Impact of flutamide on sex differentiation in rats]. ( Li, Y; Liang, Y; Wang, WD; Wu, DS; Zhang, H, 2006) |
| " A total of 59 subjects (5-8 per treatment group) received exogenous androgen (testosterone enanthate), an anti-androgen (flutamide) or vehicle injections (DMSO) for 30 or 35 days during the second (early) or third (late) trimester of pregnancy." | 3.73 | Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: life history differences and effects of prenatal androgens. ( Gouzoules, H; Tomaszycki, ML; Wallen, K, 2005) |
| " Pregnant females received daily injections of the androgen receptor antagonist flutamide from day 12 of pregnancy until pups were born." | 3.73 | Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats. ( Camacho, FJ; Domínguez-Salazar, E; Paredes, RG, 2005) |
| "We investigated whether gestational age of in utero low-protein diet played a role in the subsequent development of adult hypertension and whether it is gender dependent and examined whether flutamide (a specific, nonsteroidal competitive antagonist of the androgen receptor) reduces blood pressure in rat offspring that are exposed to in utero low-protein diet (6%)." | 3.73 | Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero. ( Gangula, PR; Reed, L; Yallampalli, C, 2005) |
| "To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology." | 3.72 | [A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004) |
| "The role of prenatal androgen on the differentiation of sexually dimorphic juvenile play and adult copulatory patterns was evaluated in male offspring of rats injected with 5 mg of the androgen receptor blocker flutamide (4'-nitro-3'-trifluoromethylisobutyranilide) from Days 11-21 of pregnancy." | 3.72 | Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide. ( Bartke, A; Casto, JM; Ward, OB, 2003) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 3.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 3.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| " Pregnant females received exogenous androgen (testosterone enanthate), an androgen antagonist (flutamide), or vehicle injections for 30 or 35 days during the second (early) or third (late) trimester of pregnancy." | 3.71 | Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens. ( Davis, JE; Gouzoules, H; Tomaszycki, ML; Wallen, K, 2001) |
| " The second experimental group of rats were given flutamide (10 mg/100 g) for ten days during pregnancy." | 3.70 | The effects of sialoadenectomy & flutamide on skin development. ( Inalöz, HS; Inalöz, SS; Ketani, MA; Ketani, S; Yilmaz, F, 2000) |
| " Treatment of pregnant females with flutamide and finasteride also markedly reduced circulating concentrations of testosterone and dihydrotestosterone in maternal plasma during pregnancy." | 3.70 | Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 2. Effects of prenatal anti-androgens. ( Coscia, EM; Drea, CM; Forger, NG; Frank, LG; Glickman, SE; Licht, P; Weldele, ML, 1998) |
| "Studies were undertaken to determine whether the anti-androgen, hydroxyflutamide, has anti-progestagenic activity by using implantation, maintenance of pregnancy, and decidualization as end points." | 3.68 | Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide. ( Armstrong, DT; Chandrasekhar, Y; Kennedy, TG, 1990) |
| " Female Wistar (W) and Sprague-Dawley (SD) rats were exposed to the anti-androgen flutamide prenatally (days 11-22 of pregnancy) and/or neonatally (days 1-10)." | 3.68 | Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats. ( Brand, T; Slob, AK, 1991) |
| "Flutamide was injected into pregnant gilts between Days 80 and 88 of gestation and into female piglets between Days 2 and 10 postnatally." | 2.77 | Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure. ( Duda, M; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M, 2012) |
| "Flutamide was given in five doses (50 mg/kg bw)." | 2.76 | Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment. ( Bilinska, B; Duda, M; Durlej, M; Hejmej, A; Knapczyk-Stwora, K; Kopera, I; Slomczynska, M, 2011) |
| "Acne vulgaris is a common reason why adult women present to dermatologists and can be a clinical challenge to treat." | 2.48 | Acne in the adult female patient: a practical approach. ( Kamangar, F; Shinkai, K, 2012) |
| "Testicular ectopy, unlike cryptorchidism, was associated with a short gubernacular ligament only." | 1.62 | Morphologic alterations of the genital mesentery implicated in testis non-descent in rats prenatally exposed to flutamide. ( Chrousos, G; Kanaka-Gantenbein, C; Kostakis, A; Mentessidou, A; Mirilas, P; Salakos, C, 2021) |
| "Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients." | 1.51 | Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy. ( Gong, H; Kuang, H; Li, Y; Ling, Y; Liu, H; Qiao, B; Wu, W; Xu, J; Yang, B; Yu, D, 2019) |
| "Our results demonstrated cryptorchidism models induced noticeable decreased fertility, significantly reduced sperm count, increased sperm abnormality rate, decreased testosterone and severe testicular damage in histomorphology." | 1.48 | Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy. ( He, DW; Lin, T; Liu, B; Long, CL; Shen, LJ; Tang, XL; Wei, GH; Wei, Y; Wu, SD; Zhou, Y, 2018) |
| " A non-monotonic dose-response relationship was not evident." | 1.46 | Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats. ( Buesen, R; Fussell, KC; Gröters, S; Jiang, X; Melching-Kollmuss, S; Schneider, S; Strauss, V; van Ravenzwaay, B, 2017) |
| "Flutamide was injected into pregnant gilts between days 80 and 88 of gestation and into female piglets between days 2 and 10 post-natally." | 1.43 | Effect of Prenatal and Neonatal Anti-Androgen Flutamide Treatment on Aquaporin 5 Expression in the Adult Porcine Ovary. ( Grzesiak, M; Knapczyk-Stwora, K; Luck, MR; Mobasheri, A; Slomczynska, M, 2016) |
| "Flutamide treatment (10 mg/kg/day subcutaneously for 10 days) reduced mean arterial pressure in protein-restricted offspring but was without significant effect in controls." | 1.42 | Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring. ( Balakrishnan, MP; Sathishkumar, K; Yallampalli, C, 2015) |
| "Flutamide treatment increased circulating testosterone yet also reduced seminal vesicle weight due to local antagonism of androgen receptor." | 1.42 | Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action. ( Cruickshanks, L; McKinnell, C; Milne, L; Mitchell, RT; Mungall, W; Sharpe, RM; Smith, LB, 2015) |
| "Flutamide treatment increased the expression of BMP4 mRNA on GD50 and GD108 and BMPR-IB mRNA on GD50." | 1.40 | TGFβ (transforming growth factor β) superfamily members and their receptors in the fetal porcine ovaries: effect of prenatal flutamide treatment. ( Duda, M; Galas, J; Grzesiak, M; Knapczyk-Stwora, K; Koziorowski, M; Slomczynska, M, 2014) |
| "Flutamide was injected subcutaneously into pregnant SD rats on gestational days 12-21 (25 mg/kg/day)." | 1.40 | Connexin 43 expression in Sprague-Dawley rat seminiferous epithelium after in utero exposure to flutamide. ( Cai, C; He, D; Ma, C; Wei, G; Wu, X; Zhang, Y; Zhao, D, 2014) |
| "No cryptorchidism was found in group A; unilateral cryptorchidism was seen in groups B (10." | 1.39 | [Expression of insulin-like factor 3 in the testis of flutamide-induced cryptorchidism mice and its significance]. ( Bai, C; Yuan, YM; Zhang, C; Zheng, M; Zhou, XJ, 2013) |
| "Flutamide was injected into pregnant gilts between days 80 and 88 of gestation, and into female piglets between days 2 and 10 postnatally." | 1.38 | Prenatal and neonatal flutamide administration increases proliferation and reduces apoptosis in large antral follicles of adult pigs. ( Durlej, M; Knapczyk-Stwora, K; Slomczynska, M, 2012) |
| "Since the majority of testicular cancers are derived from germ cells at the stage of transformation of primordial germ cell (PGC) into gonocytes, the increase has been attributed to maternal/fetal exposures to environmental factors." | 1.38 | Fetal radiation exposure induces testicular cancer in genetically susceptible mice. ( Comish, PB; Matin, A; Meistrich, ML; Shetty, G; Weng, CC, 2012) |
| "A rat model of Flu-induced cryptorchidism with remaining Gos was successfully established, which could be used to study the mechanism and management of the maldevelopment of cryptorchidism gonocytes." | 1.37 | [Establishment of a rat model of flutamide-induced cryptorchidism with remaining gonocytes]. ( He, DW; He, WF; Ma, C; Wei, GH; Zhang, YB; Zhao, D, 2011) |
| "Flutamide was injected into pregnant gilts between days 80 and 88 of gestation and into female piglets between days 2 and 10 posnatally." | 1.37 | Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin 43 gene expression in adult porcine ovary. ( Bilinska, B; Duda, M; Durlej, M; Hejmej, A; Knapczyk-Stwora, K; Kopera-Sobota, I; Slomczynska, M, 2011) |
| "Flutamide treated rats presented reductions in weight of testes and prostate, percentage of normal spermatozoa, spermatozoa concentration, testicular sperm production, and testosterone level." | 1.37 | Copulatory efficiency and fertility in male rats exposed perinatally to flutamide. ( Garcia, PC; Leonelli, C; Pereira, OC, 2011) |
| "Flutamide-treated rats (D2) showed the gubernaculum surrounded by a persisting breast bud." | 1.36 | Hidden in plain sight: the mammary line in males may be the missing link regulating inguinoscrotal testicular descent. ( Balic, A; Buraundi, S; Farmer, P; Hutson, J; Nation, T; Newgreen, D; Southwell, B, 2010) |
| "Flutamide was associated with higher levels of organized collagen and increased aggrecan expression with a greater proportion of chondroitin/dermatan sulfate glycosaminoglycans." | 1.35 | Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis. ( Chien, EK; Dailey, TL; Ji, H; Long, V, 2008) |
| " The aim was to assess whether the joint effects of vinclozolin, flutamide, and procymidone can be predicted based on dose-response data of the individual chemicals." | 1.34 | Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures. ( Axelstad, M; Christiansen, S; Dalgaard, M; Hass, U; Kiersgaard, MK; Kortenkamp, A; Metzdorff, SB; Scholze, M; Vinggaard, AM, 2007) |
| " Changes in anogenital distance (AGD) and nipple retention (NR) in male offspring rats were chosen as end points for extensive dose-response studies." | 1.34 | Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat. ( Axelstad, M; Christiansen, S; Dalgaard, M; Hass, U; Kortenkamp, A; Metzdorff, SB; Scholze, M; Vinggaard, AM, 2007) |
| "In flutamide-treated rats, DNA synthesis was suppressed until day 6, similar suppression was observed in capsaicin-treated SD, and TS rats until day 4." | 1.33 | Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve. ( Bidarkar, SS; Donath, S; Farmer, PJ; Hutson, JM; Ng, SL; Sourial, M, 2005) |
| "Flutamide is a drug with antiandrogen effects that are mediated through androgen receptors (ARs)." | 1.33 | Evaluation of general behavior, memory, learning performance, and brain sexual differentiation in F1 offspring males of rats treated with flutamide during late gestation. ( Fujii, Y; Goto, K; Hashi, M; Koizumi, K; Ohbo, N; Ohta, Y; Saika, O; Saito, K; Suzuki, H; Suzuki, K, 2005) |
| "Flutamide treatment impaired differentiation of inner stromal cells, shown by decreased expression of smooth muscle actin, before effects were noted in the epithelium, consistent with androgens driving WD development via stromal-epithelial interactions." | 1.33 | Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide. ( Marchetti, NI; Saunders, PT; Sharpe, RM; Welsh, M, 2006) |
| " Furthermore, these data suggest that dose-response studies utilizing late gestational exposure to endocrine-active compounds may be more robust than the traditional or EPA-modified multigeneration protocols in identifying adverse effects." | 1.31 | Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. ( Barlow, NJ; Foster, PM; Gaido, KW; Maness, SC; McIntyre, BS; Wallace, DG, 2000) |
| " The objectives of this study were to determine whether in utero exposure to flutamide results in permanent changes in male AGD and nipple retention, characterize the dose-response relationship between flutamide-mediated alterations in these landmarks and clearly adverse antiandrogenic effects, and establish the predictive value and relationship between AGD and nipple retention, and other adverse manifestations." | 1.31 | Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. ( Barlow, NJ; Foster, PM; McIntyre, BS, 2001) |
| "Flutamide, which has antiandrogenic properties, was administered to pregnant rats, and effects on male offspring were examined." | 1.31 | Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats. ( Matsuo, M; Miyata, K; Nakanishi, T; Okuno, Y; Sano, M; Sukata, T; Yabushita, S; Yoshino, H, 2002) |
| "Flutamide and tamoxifen treatment both suppressed FSH secretion at either age examined (p < 0." | 1.30 | Direct actions of gonadal steroid hormones on FSH secretion and expression in the infantile female rat. ( Handa, RJ; Wilson, ME, 1998) |
| " The chemical was dosed by gavage to pregnant dams at 10 or 100 mg/kg body wt from gestation day 14 to 18." | 1.30 | Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE. ( Archibeque-Engle, S; Casanova, M; Fan, LQ; Heck, HA; Sar, M; You, L, 1998) |
| "Flutamide treatment resulted in higher basal levels of testosterone and stress levels of corticosterone compared to vehicle treatment, and there was no interaction of treatment with age at time of treatment." | 1.30 | Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats. ( Mahoney, E; McCormick, CM, 1999) |
| " Pregnant Long-Evans rats were dosed by gavage from Gestation Day 14 to 18 at 0, 10 (low dose), or 100 (high dose) mg DDE, or 40 mg flutamide/kg body wt (bw)/day (in utero treatment)." | 1.30 | In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation. ( Brenneman, KA; Heck, H; You, L, 1999) |
| "The flutamide treatment had little effect on CYP enzyme expression." | 1.30 | Modulation of testosterone-metabolizing hepatic cytochrome P-450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p'-DDE. ( Archibeque-Engle, S; Bruce, JM; Casanova, M; Chan, SK; Corton, JC; Heck, H; You, L, 1999) |
| "Hydroxyflutamide is a potent nonsteroidal anti-androgenic drug extensively used in laboratory investigations." | 1.29 | Influence of the anti-androgen hydroxyflutamide on in vitro development of mouse embryos. ( Nagamani, M; Osuamkpe, C; Yallampalli, C, 1993) |
| "The decrease in undescended testes and epididymal abnormalities following epidermal growth factor treatment was significant at p < 0." | 1.29 | Epidermal growth factor reverses antiandrogen induced cryptorchidism and epididymal development. ( Cain, MP; Husmann, DA; Kramer, SA; Tindall, DJ, 1994) |
| " Dose-response studies were performed on male rats treated in utero during the period of sexual differentiation with either the potent 5 alpha-reductase inhibitor finasteride or the antiandrogen flutamide." | 1.28 | Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies. ( Imperato-McGinley, J; Sanchez, RS; Spencer, JR; Vaughan, ED; Yee, B, 1992) |
| "Cryptorchidism was enhanced when rats were treated postnatally with testosterone or oestradiol." | 1.28 | Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide. ( van der Schoot, P, 1992) |
| "Flutamide-treated males also had proportionately more large neurons than control males but fewer than females." | 1.28 | Prenatal flutamide alters sexually dimorphic nuclei in the spinal cord of male rats. ( Casto, JM; Grisham, W; Kashon, ML; Ward, IL; Ward, OB, 1992) |
| "Treatment with flutamide on days 14-20 of gestation resulted in hypospadias, the absence or only rudimentary growth of prostate and seminal vesicles, and the presence of a vagina in male offspring." | 1.27 | Inhibition of development of both androgen-dependent and androgen-independent pigment cells in scrotal skin dermis of the rat by antiandrogen treatment during fetal growth. ( Wilson, MJ, 1983) |
| " However, they were no less receptive than control females in response to a high (15 micrograms/kg) dosage of EB." | 1.27 | Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes. ( Baum, MJ; Tobet, SA, 1986) |
| "Flutamide treatment decreased the weight of accessory sex organs, stimulated the secretion of both LH (+200%) and FSH (+63%) by inhibition of the negative feedback of testosterone; endogenous testosterone secretion was increased by 363%." | 1.27 | Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan. ( Hochereau-de Reviers, MT; Perreau, C; Viguier-Martinez, MC, 1985) |
| "Treatment with cyproterone acetate at diestrus caused a decrease in the number of small follicles (less than 200 micrometer), freshly formed corpora lutea and the levels of estradiol-17beta in the ovary, suggesting inhibition of ovulation." | 1.26 | Evidence for a role of androgens in the growth and maturation of ovarian follicles in rats. ( Datta, JK; Kumari, GL; Roy, S, 1978) |
| " Males exposed prenatally to either the 1- or 5-mg dosage of flutamide exhibited significantly higher lordosis quotients than controls when given EB alone." | 1.26 | Androgenic influences on feminine sexual behavior in male and female rats: defeminization blocked by prenatal antiandrogen treatment. ( Clemens, LG; Gladue, BA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (8.87) | 18.7374 |
| 1990's | 39 (19.21) | 18.2507 |
| 2000's | 64 (31.53) | 29.6817 |
| 2010's | 70 (34.48) | 24.3611 |
| 2020's | 12 (5.91) | 2.80 |
| Authors | Studies |
|---|---|
| Drea, CM | 5 |
| Davies, CS | 1 |
| Greene, LK | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for flutamide and Pregnancy
| Article | Year |
|---|---|
Permitted Daily Exposure of the Androgen Receptor Antagonist Flutamide.
Topics: Administration, Oral; Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug; | 2017 |
Acne in the adult female patient: a practical approach.
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatologic | 2012 |
Hormonal influences on sexually differentiated behavior in nonhuman primates.
Topics: Androgen Antagonists; Androgens; Animals; Behavior, Animal; Female; Flutamide; Genitalia, Female; Ho | 2005 |
Adrenal steroid interactions in female sexual behavior : a review.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Adrenocorticotropic Hormone; Androgens; Animals; Castration; | 1980 |
4 trials available for flutamide and Pregnancy
| Article | Year |
|---|---|
Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency.
Topics: 17-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Androstenedione; Animals; Aromatase; Corpus | 2014 |
Morphological and functional alterations in adult boar epididymis: Effects of prenatal and postnatal administration of flutamide.
Topics: Androgen Antagonists; Animals; Connexin 43; Drug Administration Schedule; Epididymis; Female; Flutam | 2011 |
Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Female; Flutamide; Gene Expression Reg | 2011 |
Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Aromatase; beta Catenin; Estradiol; Female; Flutami | 2012 |
195 other studies available for flutamide and Pregnancy
| Article | Year |
|---|---|
An intergenerational androgenic mechanism of female intrasexual competition in the cooperatively breeding meerkat.
Topics: Aggression; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Animals, Wild; Breeding; Com | 2021 |
Androgens Upregulate Pathogen-Induced Placental Innate Immune Response.
Topics: Androgens; Chorioamnionitis; Female; Flutamide; Humans; Immunity, Innate; Male; Placenta; Pregnancy; | 2022 |
Protective Effects of N-Acetyl Cysteine on Undescended Testis after Orchiopexy: A Rat-model Study.
Topics: Acetylcysteine; Animals; Antioxidants; Cryptorchidism; Female; Flutamide; Humans; Male; Orchiopexy; | 2023 |
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring.
Topics: Animals; Animals, Newborn; Cryptorchidism; Dienestrol; Dose-Response Relationship, Drug; Endpoint De | 2020 |
Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs†.
Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Animals; Animals, Newborn; Cell Death; Cell Pr | 2020 |
Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide.
Topics: Androgen Antagonists; Animals; Apoptosis; Autophagy; Female; Flutamide; Gene Expression; Male; Mice, | 2020 |
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part II: Endocrine-related gene expression assessment on male offspring rat testes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dienestrol; Female; Flutamide; Gene Expression Regulation; | 2020 |
Morphologic alterations of the genital mesentery implicated in testis non-descent in rats prenatally exposed to flutamide.
Topics: Androgens; Animals; Cryptorchidism; Female; Flutamide; Genitalia, Male; Male; Mesentery; Pregnancy; | 2021 |
Non-genomic actions of sex hormones on pregnant uterine contractility in rats: An in vitro study at term.
Topics: Animals; Dose-Response Relationship, Drug; Estradiol; Female; Flutamide; Fulvestrant; Mifepristone; | 2020 |
Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus.
Topics: Animals; Female; Fetal Development; Fetus; Flutamide; Hyperandrogenism; Luteinizing Hormone; Polycys | 2020 |
Insulin and glucose responses to hypoxia in male and female neonatal rats: Effects of the androgen receptor antagonist flutamide.
Topics: Androgen Receptor Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Flutamide; | 2021 |
Flutamide induces uterus and ovary damage in the mouse via apoptosis and excessive autophagy of cells following triggering of the unfolded protein response.
Topics: Androgen Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Relate | 2021 |
Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way.
Topics: Alcohol Drinking; Androgen Receptor Antagonists; Androgens; Animals; Brain-Derived Neurotrophic Fact | 2018 |
Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats.
Topics: Animals; Dose-Response Relationship, Drug; Estrous Cycle; Female; Flutamide; Imidazoles; Male; Nippl | 2017 |
The impact of antiandrogen flutamide on the hypoxia inducible factor 1a and vascular endothelial growth factor A gene and protein expression in the pig placenta during late pregnancy.
Topics: Androgen Antagonists; Animals; Female; Flutamide; Gene Expression Regulation, Developmental; Hypoxia | 2017 |
Prenatal androgen-receptor activity has organizational morphological effects in mice.
Topics: Animals; Body Size; Dihydrotestosterone; Extremities; Female; Flutamide; Functional Laterality; Gona | 2017 |
Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy.
Topics: Androgen Antagonists; Animals; Apoptosis; Autophagosomes; Autophagy; Biomarkers; Cryptorchidism; Die | 2018 |
Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats.
Topics: Androgen Antagonists; Animals; Antioxidants; Endoglin; Female; Flutamide; Glucosephosphate Dehydroge | 2018 |
Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities.
Topics: Adenosine Deaminase; Androgen Receptor Antagonists; Animals; Animals, Newborn; Antioxidants; Female; | 2018 |
[Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring].
Topics: Animals; Female; Flutamide; Genitalia, Male; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Oxidativ | 2018 |
Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy.
Topics: Androgen Antagonists; Animals; Decidua; Disease Models, Animal; Embryo Implantation; Female; Flutami | 2019 |
Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro.
Topics: Androgen Antagonists; Animals; Blood-Testis Barrier; Connexins; Cryptorchidism; Female; Flutamide; I | 2019 |
Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats.
Topics: Androgen Antagonists; Androgens; Animals; Body Composition; Diabetes Mellitus, Type 2; Diet, High-Fa | 2019 |
In utero exposure to the anti-androgen flutamide influences connexin 43 and β-catenin expression in porcine fetal gonads.
Topics: Androgen Antagonists; Androgens; Animals; beta Catenin; Connexin 43; Female; Flutamide; Gene Express | 2013 |
Antiandrogen flutamide affects folliculogenesis during fetal development in pigs.
Topics: Androgen Antagonists; Animals; Apoptosis; Cadherins; Cell Proliferation; Female; Fetus; Flutamide; G | 2013 |
Effect of flutamide on folliculogenesis in the fetal porcine ovary--regulation by Kit ligand/c-Kit and IGF1/IGF1R systems.
Topics: Androgen Antagonists; Animals; Female; Fetus; Flutamide; Gene Expression Regulation, Developmental; | 2013 |
Flutamide influences placental aldo-keto reductase family 1 member C1 (AKR1C1) expression in pigs.
Topics: 20-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Aldo-Keto Reductases; Androgen Antagonists; An | 2014 |
[Expression of insulin-like factor 3 in the testis of flutamide-induced cryptorchidism mice and its significance].
Topics: Animals; Cryptorchidism; Female; Flutamide; Insulin; Male; Maternal Exposure; Mice; Mice, Inbred BAL | 2013 |
Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum.
Topics: Androgen Antagonists; Androgens; Animals; Corpus Luteum; Female; Flutamide; Pregnancy; Progesterone; | 2014 |
Connexin 43 expression in Sprague-Dawley rat seminiferous epithelium after in utero exposure to flutamide.
Topics: Androgen Antagonists; Animals; Connexin 43; Epithelium; Female; Flutamide; Male; Maternal Exposure; | 2014 |
Identification of gene expression changes in postnatal rat foreskin after in utero anti-androgen exposure.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Female; Flutamide; Foreskin; Gene Expression Regul | 2014 |
Altered expression of 3β-HSD, CYP17 and 17β-HSD in the foetal porcine gonads in response to anti-androgen flutamide exposure.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Fe | 2014 |
Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring.
Topics: Androgen Antagonists; Androgens; Animals; Body Weight; Brain; Female; Flutamide; Hippocampus; Male; | 2014 |
Prenatal influence of an androgen agonist and antagonist on the differentiation of the ovine sexually dimorphic nucleus in male and female lamb fetuses.
Topics: Androgen Antagonists; Androgens; Animals; Dihydrotestosterone; Female; Flutamide; Hypothalamo-Hypoph | 2014 |
Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.
Topics: Androgen Antagonists; Androgens; Animals; Biomarkers; Cohort Studies; Estrogens; Female; Flutamide; | 2015 |
TGFβ (transforming growth factor β) superfamily members and their receptors in the fetal porcine ovaries: effect of prenatal flutamide treatment.
Topics: Androgen Antagonists; Animals; Bone Morphogenetic Protein 4; Female; Flutamide; Gene Expression Regu | 2014 |
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.
Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring.
Topics: Androgen Antagonists; Angiotensin II; Animals; Female; Flutamide; Mesenteric Arteries; Pregnancy; Pr | 2015 |
Developmental programming: exposure to testosterone excess disrupts steroidal and metabolic environment in pregnant sheep.
Topics: Animals; Birth Weight; Blood Glucose; Female; Flutamide; Insulin; Pregnancy; Progesterone; Reproduct | 2015 |
Influence of the antiandrogen flutamide on connexin 43 (Cx43) gene and protein expression in the porcine placenta and uterus during pregnancy.
Topics: Androgen Antagonists; Animals; Connexin 43; Female; Flutamide; Gene Expression Regulation; Placenta; | 2014 |
Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep.
Topics: Androgen Antagonists; Androgens; Animals; Estrous Cycle; Female; Fetal Development; Flutamide; Hypog | 2015 |
Flutamide alters β-catenin expression and distribution, and its interactions with E-cadherin in the porcine corpus luteum of mid- and late pregnancy.
Topics: Androgen Antagonists; Animals; beta Catenin; Cadherins; Corpus Luteum; Female; Flutamide; Gene Expre | 2015 |
Follicular hyperandrogenism downregulates aromatase in luteinized granulosa cells in polycystic ovary syndrome women.
Topics: Adult; Androgen Antagonists; Aromatase; Cell Line; Down-Regulation; Female; Fertilization in Vitro; | 2015 |
Effect of gestational antiandrogen treatment on Dicer1 expression in the porcine fetal gonads.
Topics: Androgen Antagonists; Animals; Cytoplasm; Female; Fetus; Flutamide; Gene Expression; Male; Maternal- | 2015 |
Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep.
Topics: Adiposity; Animals; Disease Models, Animal; Embryonic Development; Female; Flutamide; Insulin Resist | 2016 |
Effect of Prenatal and Neonatal Anti-Androgen Flutamide Treatment on Aquaporin 5 Expression in the Adult Porcine Ovary.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Aquaporin 5; Female; Flutamide; Gene Expression; Im | 2016 |
Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Decidua; Endometrium; Female; Flutamide; Gene Expr | 2016 |
Effects of Long-Term Flutamide Treatment During Development on Sexual Behaviour and Hormone Responsiveness in Rams.
Topics: Androgen Receptor Antagonists; Animals; Estradiol; Female; Flutamide; Gonadal Steroid Hormones; Gona | 2016 |
Analysis of 17β-estradiol (E2) role in the regulation of corpus luteum function in pregnant rats: Involvement of IGFBP5 in the E2-mediated actions.
Topics: Anastrozole; Androgen Antagonists; Animals; Aromatase Inhibitors; Cell Proliferation; Corpus Luteum; | 2016 |
Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted Rats.
Topics: Animals; Animals, Newborn; Birth Weight; Blood Pressure Determination; Disease Models, Animal; Femal | 2016 |
Manipulation of pre and postnatal androgen environments and anogenital distance in rats.
Topics: Androgen Antagonists; Androgens; Animals; Diethylhexyl Phthalate; Disease Models, Animal; Dose-Respo | 2016 |
Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS.
Topics: Androgen Antagonists; Androgens; Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; F | 2016 |
Induction of autophagy in the porcine corpus luteum of pregnancy following anti-androgen treatment.
Topics: Androgen Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Corpus | 2016 |
Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Dose-Response Relationship, Drug; Female; Flutamide; Ma | 2008 |
Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis.
Topics: Androgen Antagonists; Animals; Cholesterol Side-Chain Cleavage Enzyme; DNA Primers; Female; Fetal De | 2009 |
OECD validation of phase 3 Hershberger assay in Korea using surgically castrated male rats with coded chemicals.
Topics: Anabolic Agents; Androgen Antagonists; Androgens; Animals; Biological Assay; Body Weight; Dichlorodi | 2009 |
Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations.
Topics: Androgen Antagonists; Animals; Base Sequence; Bridged Bicyclo Compounds; DNA Methylation; Female; Fl | 2009 |
Androgen receptors in coeliac ganglion in late pregnant rat.
Topics: 20-alpha-Hydroxysteroid Dehydrogenase; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Andros | 2009 |
Critical androgen-sensitive periods of rat penis and clitoris development.
Topics: Androgens; Animals; Clitoris; Female; Flutamide; Genitalia; Male; Penis; Pregnancy; Rats; Rats, Wist | 2010 |
Connexin 43 gene expression in male and female gonads of porcine offspring following in utero exposure to an anti-androgen, flutamide.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Female; Flutamide; Gene Expression; Im | 2011 |
Androgen action in the masculinization programming window and development of male reproductive organs.
Topics: Androgen Antagonists; Androgens; Animals; Animals, Newborn; Dibutyl Phthalate; Female; Flutamide; Ge | 2010 |
The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Division; Cell Movement; Cryptorchidism; Disea | 2009 |
Hidden in plain sight: the mammary line in males may be the missing link regulating inguinoscrotal testicular descent.
Topics: Abdominal Wall; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Animals, | 2010 |
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.
Topics: Animals; Dibutyl Phthalate; Female; Fetus; Flutamide; Immunohistochemistry; Male; Organ Size; Pregna | 2010 |
Immunohistochemical studies on the proliferative marker Ki-67 and estrogen receptor alpha (ERα) in the uterus of neonatal and immature pigs following exposure to flutamide.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Biomarkers; Cell Proliferation; Connective Tissue; | 2011 |
The expression of FSH receptor (FSHR) in the neonatal porcine ovary and its regulation by flutamide.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Female; Flutamide; Follicle Stimulating Hormone; Ge | 2011 |
Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy.
Topics: Alleles; Anatomy, Cross-Sectional; Androgen Antagonists; Animals; Behavior, Animal; Bulbo-Spinal Atr | 2011 |
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
Copulatory efficiency and fertility in male rats exposed perinatally to flutamide.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Copulation; Female; Fertility; Flutamide; Genitalia | 2011 |
Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin 43 gene expression in adult porcine ovary.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Corpu | 2011 |
The anti-androgen combination, flutamide plus finasteride, paradoxically suppressed LH and androgen concentrations in pregnant spotted hyenas, but not in males.
Topics: Androgen Antagonists; Androstenedione; Animals; Estradiol; Feedback; Female; Finasteride; Flutamide; | 2011 |
[Establishment of a rat model of flutamide-induced cryptorchidism with remaining gonocytes].
Topics: Animals; Cryptorchidism; Female; Flutamide; Male; Neural Cell Adhesion Molecules; Pregnancy; Rats; R | 2011 |
Effect of methanol extract of Basella alba L. (Basellaceae) on the fecundity and testosterone level in male rats exposed to flutamide in utero.
Topics: Androgen Receptor Antagonists; Animals; Female; Fertility; Fetus; Flutamide; Magnoliopsida; Male; Me | 2012 |
Developmental programming: gestational testosterone treatment alters fetal ovarian gene expression.
Topics: Androgen Antagonists; Androgens; Animals; Estrogens; Female; Fetal Development; Flutamide; Gene Expr | 2011 |
The effect of flutamide on expression of androgen and estrogen receptors in the gubernaculum and surrounding structures during testicular descent.
Topics: Androgen Antagonists; Animals; Cell Nucleus; Cryptorchidism; Estrogen Receptor alpha; Estrogen Recep | 2011 |
Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.
Topics: Adaptor Proteins, Signal Transducing; Androgen Antagonists; Androgens; Animals; beta Catenin; Carrie | 2011 |
Prenatal and neonatal exposure to flutamide affects function of Leydig cells in adult boar.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Size; Estradiol; Female; Flutamide; Follicle S | 2012 |
Fetal radiation exposure induces testicular cancer in genetically susceptible mice.
Topics: Androgen Antagonists; Animals; Diethylstilbestrol; Estrogens, Non-Steroidal; Female; Fetus; Flutamid | 2012 |
Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Estradiol; Estrogens; Feedback, Phys | 2012 |
Prenatal and neonatal flutamide administration increases proliferation and reduces apoptosis in large antral follicles of adult pigs.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Apoptosis; Cell Growth Processes; Estradiol; Female | 2012 |
Influence of the antiandrogen flutamide on the androgen receptor gene expression in the placenta and umbilical cord during pregnancy in the pig.
Topics: Animals; Blotting, Western; Female; Flutamide; Gene Expression Regulation; Immunohistochemistry; Pla | 2013 |
Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.
Topics: Androgen Antagonists; Animals; Animals, Outbred Strains; Apoptosis; Biomarkers; DNA Methylation; End | 2012 |
Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta.
Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Carnivora; Chorionic Gonadotropin; Female; Fi | 2002 |
Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating.
Topics: Androgen Antagonists; Androgens; Animals; Carnivora; Enzyme Inhibitors; Female; Finasteride; Flutami | 2002 |
Chronic administration of anabolic steroids disrupts pubertal onset and estrous cyclicity in rats.
Topics: Anabolic Agents; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Body Weight; Drug Adm | 2003 |
Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide.
Topics: Age Factors; Androgen Antagonists; Animals; Apoptosis; Caspase 3; Caspase 6; Caspases; Female; Fluta | 2003 |
Sex differences in interest in infants in juvenile rhesus monkeys: relationship to prenatal androgen.
Topics: Age Factors; Analysis of Variance; Androgen Antagonists; Animals; Behavior, Animal; Female; Flutamid | 2003 |
Alteration of lactate production and transport in the adult rat testis exposed in utero to flutamide.
Topics: Androgen Antagonists; Animals; Biological Transport; Female; Flutamide; Isoenzymes; L-Lactate Dehydr | 2003 |
Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide.
Topics: Androgen Antagonists; Animals; Copulation; Female; Flutamide; Genitalia, Male; Male; Play and Playth | 2003 |
Effects of perinatal exposure to flutamide on sex hormone responsiveness in F1 male rats.
Topics: Androgen Antagonists; Androgens; Animals; Biological Assay; Female; Flutamide; Follicle Stimulating | 2003 |
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna | 2004 |
Evidence that inhibited prostatic epithelial bud formation in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed C57BL/6J fetal mice is not due to interruption of androgen signaling in the urogenital sinus.
Topics: Androgen Antagonists; Animals; Cells, Cultured; Dihydrotestosterone; Environmental Pollutants; Epith | 2004 |
[A mouse model of hypospadias induced by flutamide].
Topics: Androgen Antagonists; Animals; Disease Models, Animal; Female; Fetus; Flutamide; Hypospadias; Male; | 2004 |
Endocrine-disrupting activity in carbendazim-induced reproductive and developmental toxicity in rats.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Benomyl; Benzimidazoles; Carbamates; Dos | 2004 |
The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens.
Topics: Androgen Antagonists; Animals; Apoptosis; Dose-Response Relationship, Drug; Embryonic Development; F | 2004 |
Factors regulating the timing of puberty onset in female rhesus monkeys (Macaca mulatta): role of prenatal androgens, social rank, and adolescent body weight.
Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Body Weight; Female; Flutamide; Gestational A | 2005 |
Application of an antiandrogen during pregnancy infantilizes the male offsprings' behaviour.
Topics: Age Factors; Agonistic Behavior; Androgen Antagonists; Animals; Behavior, Animal; Female; Flutamide; | 2005 |
Effects of in utero and lactational exposure to flutamide in SD rats: comparison of the effects of administration periods.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Fl | 2005 |
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation | 2004 |
Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diet, Protein-Restricted; Female; Flutamide; Gesta | 2005 |
Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Calcitonin Gene-Re | 2005 |
Androgens induce relaxation of contractile activity in pregnant human myometrium at term: a nongenomic action on L-type calcium channels.
Topics: Androgen Antagonists; Androgens; Androstenediol; Androsterone; Calcium Channels, L-Type; Dehydroepia | 2005 |
19-Nortestosterone influences neural stem cell proliferation and neurogenesis in the rat brain.
Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Blotting, Western; Brain; Bromodeoxyuridine; | 2005 |
Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages.
Topics: Androgen Antagonists; Androgens; Animals; Cryptorchidism; Epididymis; Female; Flutamide; Genitalia, | 2005 |
The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action.
Topics: 17-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Cholesterol Side-Chain Cleavage Enz | 2005 |
Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Conditioning, Psychological; Estrus; F | 2005 |
Prenatal androgen blockade accelerates pubertal development in male rhesus monkeys.
Topics: Androgen Antagonists; Animals; Female; Flutamide; Gonadotropin-Releasing Hormone; Hierarchy, Social; | 2006 |
Evaluation of general behavior, memory, learning performance, and brain sexual differentiation in F1 offspring males of rats treated with flutamide during late gestation.
Topics: Androgen Antagonists; Animals; Avoidance Learning; Behavior, Animal; Castration; Dose-Response Relat | 2005 |
Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: life history differences and effects of prenatal androgens.
Topics: Agonistic Behavior; Androgen Antagonists; Animals; Discriminant Analysis; Female; Flutamide; Macaca | 2005 |
Germ cell atypia in undescended testes hinges on the aetiology of cryptorchidism but not the abdominal location per se.
Topics: Abdomen; Androgen Antagonists; Animals; Carcinoma in Situ; Cryptorchidism; Dichlorodiphenyl Dichloro | 2006 |
[Impact of flutamide on sex differentiation in rats].
Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Hypospadias; Male; Pregnancy; Pren | 2006 |
Sex differences in otoacoustic emissions measured in rhesus monkeys (Macaca mulatta).
Topics: Androgen Antagonists; Androgens; Animal Communication; Animals; Cochlea; Data Interpretation, Statis | 2006 |
Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide.
Topics: Androgen Antagonists; Androgens; Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell P | 2006 |
[The effects of flutamide on the full gene expression of early testis development of embryonic period male SD].
Topics: Androgen Antagonists; Animals; Female; Flutamide; Gene Expression Profiling; Gene Expression Regulat | 2006 |
Role of androgens in fetal testis development and dysgenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androgen Antagonists; Animals; Body Weight; Carcinogens; Dibutyl P | 2007 |
Cognitive performance in rhesus monkeys varies by sex and prenatal androgen exposure.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Discrimination Learning; Female; Flu | 2007 |
Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures.
Topics: Algorithms; Androgen Antagonists; Animals; Body Weight; Bridged Bicyclo Compounds; Endpoint Determin | 2007 |
The critical time window for androgen-dependent development of the Wolffian duct in the rat.
Topics: Androgen Antagonists; Androgens; Animals; Blotting, Western; Cell Differentiation; Cell Proliferatio | 2007 |
Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.
Topics: Anastrozole; Androgen Antagonists; Androgens; Animals; Aromatase Inhibitors; Cell Death; Cells, Cult | 2007 |
Activation of the androgen receptor alters the intracellular calcium response to glutamate in primary hippocampal neurons and modulates sarco/endoplasmic reticulum calcium ATPase 2 transcription.
Topics: Androgen Antagonists; Androgens; Animals; Calcium; Cells, Cultured; Dihydrotestosterone; Dose-Respon | 2007 |
In vivo and in vitro effects of flutamide and diethylstilbestrol on fetal testicular steroidogenesis in the rat.
Topics: Androgen Antagonists; Animals; Autocrine Communication; Diethylstilbestrol; Dose-Response Relationsh | 2008 |
The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the rat.
Topics: Abdominal Muscles; Animals; Animals, Newborn; Cryptorchidism; Disease Models, Animal; Female; Flutam | 2007 |
Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat.
Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Syn | 2007 |
Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.
Topics: Androgen Antagonists; Animals; Apoptosis; Cells, Cultured; Coculture Techniques; Down-Regulation; Fe | 2008 |
Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Biomechanical Phenomena; Ce | 2008 |
Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum.
Topics: Androgen Antagonists; Animals; Cell Differentiation; Cell Lineage; Cloaca; Endoderm; Female; Flutami | 2008 |
Testicular hormones and intermale aggressive behaviour in the presence of a female rat.
Topics: Aggression; Androgen Antagonists; Animals; Castration; Estrus; Female; Flutamide; Male; Pregnancy; R | 1984 |
Effects of an anti-androgen and 5 alpha-reductase inhibitors on estrus duration in the cycling female rat.
Topics: Anilides; Animals; Azasteroids; Castration; Dihydrotestosterone; Estradiol; Estrus; Female; Flutamid | 1983 |
Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide.
Topics: Aging; Anilides; Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Muscle Development; Neur | 1983 |
Inhibition of development of both androgen-dependent and androgen-independent pigment cells in scrotal skin dermis of the rat by antiandrogen treatment during fetal growth.
Topics: Androgen Antagonists; Animals; Cell Differentiation; Female; Fetus; Flutamide; Growth; Male; Melanoc | 1983 |
Dihydrotestosterone inhibits fetal rabbit pulmonary surfactant production.
Topics: Animals; Body Weight; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Flutamide; Huma | 1982 |
Effect of anti-androgen and 5 alpha-reductase inhibitor on hormone-induced sexual behavior during pregnancy in the rat.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Castration; Dihydrotestosterone; Estradiol; Fema | 1980 |
Flutamide-induced cryptorchidism in the rat is associated with altered gubernacular morphology.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Gestational Age; Male; Pregnancy; | 1995 |
The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen.
Topics: Androgens; Animals; Blotting, Western; Dihydrotestosterone; Female; Flutamide; Male; Pregnancy; Rats | 1994 |
Alterations in maternal epidermal growth factor (EGF) effect testicular descent and epididymal development.
Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epidermal Growth Factor; Epididymis; Female; F | 1994 |
Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats.
Topics: Animals; Capsaicin; Cryptorchidism; Female; Flutamide; Male; Pregnancy; Prenatal Exposure Delayed Ef | 1994 |
Expression of androgen receptor protein within the lumbar spinal cord during ontologic development and following antiandrogen induced cryptorchidism.
Topics: Animals; Cell Count; Cryptorchidism; Female; Flutamide; Immunohistochemistry; Lumbosacral Region; Ma | 1994 |
Epidermal growth factor reverses antiandrogen induced cryptorchidism and epididymal development.
Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epidermal Growth Factor; Epididymis; Female; F | 1994 |
Influence of the anti-androgen hydroxyflutamide on in vitro development of mouse embryos.
Topics: Androgen Antagonists; Animals; Blastomeres; Cells, Cultured; Cleavage Stage, Ovum; Dose-Response Rel | 1993 |
Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; Animals, Newborn; Brain Chemistry; Cytoch | 1993 |
Aberrant hormone balance in fetal autoimmune NZB/W mice following prenatal exposure to testosterone excess or the androgen blocker flutamide.
Topics: alpha-Fetoproteins; Androgen Antagonists; Animals; Aromatase; Autoimmunity; Estradiol; Female; Fetal | 1995 |
The abnormal development of male sex organs in the rat using a pure antiandrogen and a 5 alpha-reductase inhibitor during gestation.
Topics: Androgen Antagonists; Animals; Enzyme Inhibitors; Female; Finasteride; Flutamide; Genitalia, Male; M | 1995 |
Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone.
Topics: Animals; Diethylstilbestrol; Dihydrotestosterone; Epidermal Cells; Epidermis; Female; Fetus; Flutami | 1996 |
Developmental pattern and regulation by androgens of androgen receptor expression in the urogenital tract of the rat.
Topics: Androgen Antagonists; Androgens; Animals; Dihydrotestosterone; Epididymis; Female; Flutamide; Gestat | 1995 |
Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice.
Topics: Androgen Antagonists; Androgens; Animals; Epididymis; Female; Flutamide; Genitalia, Male; Gestationa | 1995 |
[The effect of prenatal stress on the development of hypophyseal gonadotropic function in male rats].
Topics: Androgen Antagonists; Androstatrienes; Animals; Aromatase; Aromatase Inhibitors; Cholestenone 5 alph | 1996 |
Scanning electron microscopy shows inhibited gubernacular development in relation to undescended testes in oestrogen-treated mice.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Embryo, Mammalian; Estrogens; Female; Flutamide; Male | 1996 |
Interaction of mouse placental lactogens and androgens in regulating progesterone release in cultured mouse luteal cells.
Topics: Androgen Receptor Antagonists; Androgens; Androstenedione; Animals; Aromatase Inhibitors; Cattle; Ce | 1997 |
Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal life.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen Antagonists; Animals; Blotting, Southern; Brain; Fem | 1998 |
Direct actions of gonadal steroid hormones on FSH secretion and expression in the infantile female rat.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dihydrotestosterone; Estradiol; Female; Flutamide; Folli | 1998 |
Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 2. Effects of prenatal anti-androgens.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androstenedione; Animals; Carnivora; Cyproterone | 1998 |
Androgen-dependent modulation of calbindin-D28K in hypothalamic tissue during prenatal development.
Topics: Anal Canal; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Blotting, Western; Brain | 1998 |
Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE.
Topics: Animals; Animals, Suckling; Brain; Dichlorodiphenyl Dichloroethylene; Female; Flutamide; Genitalia, | 1998 |
Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats.
Topics: Age Factors; Anal Canal; Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Corticosteron | 1999 |
Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Cryptorchid | 1999 |
Androgens modulate interleukin-6 production by gingival fibroblasts in vitro.
Topics: Androgen Antagonists; Androgens; Cells, Cultured; Culture Media, Conditioned; Dihydrotestosterone; D | 1999 |
Modulation of testosterone-metabolizing hepatic cytochrome P-450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p'-DDE.
Topics: Age Factors; Androgen Antagonists; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme S | 1999 |
Prenatal flutamide treatment eliminates the adult male rat's dependency upon vasopressin when forming social-olfactory memories.
Topics: Androgen Antagonists; Animals; Cognition; Female; Flutamide; Male; Memory; Pregnancy; Prenatal Expos | 1999 |
In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation.
Topics: Adipose Tissue; Administration, Oral; Androgen Antagonists; Animals; Blotting, Northern; Clusterin; | 1999 |
Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Animals, Newborn; Female; Flutamide; H | 2000 |
Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat.
Topics: Androgens; Animals; Animals, Newborn; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; | 2000 |
Influence of gonadal hormones on the development of parental behavior in adult virgin prairie voles (Microtus ochrogaster).
Topics: Androgen Antagonists; Androstatrienes; Animals; Aromatase Inhibitors; Arvicolinae; Enzyme Inhibitors | 2000 |
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Disease Models, Animal; Female; Fertility; Flutamide; | 2000 |
Sexual dimorphism and aromatase in the rat retina.
Topics: Androgen Antagonists; Animals; Aromatase; Female; Flutamide; Male; Orchiectomy; Pregnancy; Rats; Rat | 2001 |
The effects of sialoadenectomy & flutamide on skin development.
Topics: Androgen Antagonists; Animals; Atrophy; Epidermal Growth Factor; Epidermis; Female; Flutamide; Hair | 2000 |
The biological effect of phthalate esters on transabdominal migration of the testis in fetal rats in comparison with the antiandrogen flutamide.
Topics: Animals; Cryptorchidism; Female; Flutamide; Gestational Age; Humans; Infant, Newborn; Male; Phthalic | 2001 |
Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens.
Topics: Androgen Antagonists; Androgens; Animals; Anxiety, Separation; Female; Flutamide; Macaca mulatta; Ma | 2001 |
Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues.
Topics: Anal Canal; Androgen Antagonists; Androgens; Animals; Dose-Response Relationship, Drug; Female; Flut | 2001 |
Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate.
Topics: Androgen Antagonists; Animals; Clusterin; Dibutyl Phthalate; Female; Fetus; Flutamide; Gene Expressi | 2001 |
Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory.
Topics: Androgen Antagonists; Animals; Behavior, Animal; Cues; Estrogens, Non-Steroidal; Female; Flutamide; | 2001 |
Effect of prenatal androgen receptor antagonist or aromatase inhibitor on sexual behavior, partner preference and neuronal Fos responses to estrous female odors in the rat accessory olfactory system.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androstatrienes; Animals; Aromatase Inhibitors; | 2002 |
Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Androgen Antagonists; Animals; Animals, Newborn; | 2002 |
Evidence for a role of androgens in the growth and maturation of ovarian follicles in rats.
Topics: Androgens; Animals; Corpus Luteum; Cyproterone; Diestrus; Estradiol; Estrus; Female; Flutamide; Ovar | 1978 |
Androgenic influences on feminine sexual behavior in male and female rats: defeminization blocked by prenatal antiandrogen treatment.
Topics: Anilides; Animals; Castration; Estradiol; Female; Flutamide; Male; Maternal-Fetal Exchange; Pregnanc | 1978 |
Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies.
Topics: 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Androstenes; Animals; Azasteroids; Dose | 1992 |
Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens.
Topics: Androgens; Animals; Atrophy; Cryptorchidism; Drug Combinations; Female; Flutamide; Gestational Age; | 1992 |
Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide.
Topics: Androgen-Insensitivity Syndrome; Animals; Body Weight; Chi-Square Distribution; Cryptorchidism; Epid | 1992 |
The effect of androgen, estrogen, and growth factors on the proliferation of cultured fibroblasts derived from human fetal and adult prostates.
Topics: Cell Division; Cells, Cultured; Dihydrotestosterone; Epidermal Growth Factor; Estradiol; Female; Fet | 1992 |
Prenatal flutamide alters sexually dimorphic nuclei in the spinal cord of male rats.
Topics: Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Neurons; Pregnancy; Rats; Rats, Inbred St | 1992 |
Effects of flutamide and finasteride on rat testicular descent.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgens; Androstenes; Animals; Azasteroids; Cr | 1991 |
Time-specific androgen blockade with flutamide inhibits testicular descent in the rat.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Azasteroids; Cryptorchidism; Embryonic and Fetal | 1991 |
Effects of prenatal antiandrogen treatment on masculinization and defeminization of guinea pigs.
Topics: Androgen Antagonists; Animals; Estradiol; Female; Flutamide; Guinea Pigs; In Vitro Techniques; Male; | 1991 |
Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats.
Topics: Animals; Animals, Newborn; Estrus; Female; Fetus; Flutamide; Hysterectomy; Male; Pregnancy; Prenatal | 1991 |
Hormonal manipulation of the prenatal environment alters reproductive morphology and increases longevity in autoimmune NZB/W mice.
Topics: Animals; Autoimmune Diseases; Female; Fetus; Flutamide; Hormones; Longevity; Male; Maternal-Fetal Ex | 1991 |
On the organization of partner preference behavior in female Wistar rats.
Topics: Androgen Antagonists; Animals; Copulation; Dihydrotestosterone; Dose-Response Relationship, Drug; Es | 1991 |
Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide.
Topics: Anilides; Animals; Decidua; Embryo Implantation; Embryo Implantation, Delayed; Female; Flutamide; Pr | 1990 |
Hypogastric ganglion perinatal development: evidence for androgen specificity via androgen receptors.
Topics: Adrenergic Fibers; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Flutamide; Hypo | 1989 |
Studies on the mechanism of action of Win 49596: a steroidal androgen receptor antagonist.
Topics: Androgen Receptor Antagonists; Animals; Female; Flutamide; Genitalia, Male; Male; Microsomes; Placen | 1989 |
Embryonic sex steroids affect mating behavior and plasma LH in adult chickens.
Topics: Androstatrienes; Animals; Chickens; Estradiol; Female; Flutamide; Gonadal Steroid Hormones; Luteiniz | 1989 |
Effects of an antiandrogen, flutamide, on oocyte quality and embryo development in rats superovulated with pregnant mare's serum gonadotropin.
Topics: Androgens; Anilides; Animals; Embryonic and Fetal Development; Embryonic Development; Estradiol; Fem | 1988 |
Nipple development and pup-induced prolactin release in male rats treated prenatally with the antiandrogen flutamide.
Topics: Anilides; Animals; Breast; Estradiol; Female; Flutamide; Lactation; Male; Maternal Behavior; Nipples | 1988 |
Perinatal androgen manipulations do not affect feminine behavioral potentials in voles.
Topics: Androgens; Androstatrienes; Animals; Animals, Newborn; Arvicolinae; Estradiol; Female; Flutamide; Ma | 1986 |
Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes.
Topics: Androstatrienes; Anilides; Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Estradio | 1986 |
Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan.
Topics: Anilides; Animals; Body Weight; Busulfan; Female; Flutamide; Follicle Stimulating Hormone; Hypothala | 1985 |
Prenatal antiandrogen feminizes behavioral but not neurochemical response to estrogen.
Topics: Androgen Antagonists; Animals; Brain Chemistry; Estradiol; Estrogens; Female; Flutamide; Male; Ovari | 1985 |