Page last updated: 2024-10-27

flutamide and Pregnancy

flutamide has been researched along with Pregnancy in 203 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Recently, we have found that flutamide-induced androgen deficiency altered progesterone production in the porcine corpus luteum (CL) during mid- and late pregnancy."9.19Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency. ( Ciereszko, RE; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech, I, 2014)
" Female Sprague-Dawley rats were administrated flutamide during late pregnancy to induce a model of cryptorchidism in male offspring."7.91Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Peng, J; Shen, L; Tao, X; Timashev, P; Wei, G; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2019)
"Choose 7-week-old ICR mice, female mice were randomly divided into experimental group and control group after pregnancy, thenflutamide was orally administered to pregnant mice with dose 300 mg/( kg·d) during gestation days 12-18, while the control group was treated with equal volume of soybean oil."7.88[Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring]. ( Wen, K; Yang, J; Zhou, X; Zhu, Y, 2018)
"Pregnant pigs were injected daily with antiandrogen flutamide, at a dose of 50 mg/kg body weight at different stages of pregnancy: between gestational days 83-89 (90 dpc) and 101-107 (108 dpc)."7.85The impact of antiandrogen flutamide on the hypoxia inducible factor 1a and vascular endothelial growth factor A gene and protein expression in the pig placenta during late pregnancy. ( Czaja, E; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech-Rojkiewicz, I, 2017)
"This study examined whether flutamide-induced androgen deficiency during mid- and late pregnancy in pigs affected luteal expression of adherens junction protein, β-catenin, and its interactions with E-cadherin."7.81Flutamide alters β-catenin expression and distribution, and its interactions with E-cadherin in the porcine corpus luteum of mid- and late pregnancy. ( Grzesiak, M; Janik, ME; Knapczyk-Stwora, K; Mitan, A; Slomczynska, M, 2015)
"The aim of this study was to determine the immunolocalization and expression of the androgen receptor (AR) in the pig placenta and umbilical cord during pregnancy following exposure to flutamide, a non-steroidal antiandrogen, at its various stages."7.79Influence of the antiandrogen flutamide on the androgen receptor gene expression in the placenta and umbilical cord during pregnancy in the pig. ( Durlej-Grzesiak, M; Słomczyńska, M; Wieciech, I, 2013)
"Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls."7.72Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004)
"The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring."7.72Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004)
"To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology."7.72[A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004)
"Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients."5.51Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy. ( Gong, H; Kuang, H; Li, Y; Ling, Y; Liu, H; Qiao, B; Wu, W; Xu, J; Yang, B; Yu, D, 2019)
"Flutamide treatment caused fluctuations in Cx43 expression especially before parturition."5.40Influence of the antiandrogen flutamide on connexin 43 (Cx43) gene and protein expression in the porcine placenta and uterus during pregnancy. ( Grzesiak, M; Knapczyk-Stwora, K; Pytlik, A; Słomczynska, M; Wieciech, I, 2014)
"Recently, we have found that flutamide-induced androgen deficiency altered progesterone production in the porcine corpus luteum (CL) during mid- and late pregnancy."5.19Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency. ( Ciereszko, RE; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech, I, 2014)
" Exposure to flutamide during pregnancy will also cause abnormalities in some male offspring reproductive organs such as cryptorchidism."3.96Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide. ( Fu, H; Wen, K; Yan, Z; Yu, H; Zhang, Y; Zhou, X; Zhu, J; Zhu, Y, 2020)
" Female Sprague-Dawley rats were administrated flutamide during late pregnancy to induce a model of cryptorchidism in male offspring."3.91Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Peng, J; Shen, L; Tao, X; Timashev, P; Wei, G; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2019)
" The role of sodium acetate on cardiac uric acid (UA) production and glucose-6-phosphate dehydrogenase (G6PD)-dependent antioxidant defense in pregnancy is not known."3.88Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats. ( Areola, ED; Badmus, OO; Olatunji, LA, 2018)
"Choose 7-week-old ICR mice, female mice were randomly divided into experimental group and control group after pregnancy, thenflutamide was orally administered to pregnant mice with dose 300 mg/( kg·d) during gestation days 12-18, while the control group was treated with equal volume of soybean oil."3.88[Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring]. ( Wen, K; Yang, J; Zhou, X; Zhu, Y, 2018)
" This study tested whether 1) in utero cotreatment of prenatally T-treated sheep with androgen antagonist (flutamide) or insulin sensitizer (rosiglitazone) prevents juvenile insulin resistance and adult changes in adipocyte size; and 2) visceral adiposity and insulin sensitivity are both unaltered during early adulthood, confirming the predicted developmental trajectory in this animal model."3.83Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. ( Beckett, E; Cardoso, RC; Chazenbalk, G; Dumesic, D; Keller, E; Madrigal, V; Moeller, J; Padmanabhan, V; Pease, A; Veiga-Lopez, A, 2016)
"During days 12-15 of pregnancy in rats, luteal E2 was inhibited by way of daily oral administration of anastrozole (AI), a selective non-steroidal aromatase inhibitor, and experiments were also performed with E2 replacement i."3.83Analysis of 17β-estradiol (E2) role in the regulation of corpus luteum function in pregnant rats: Involvement of IGFBP5 in the E2-mediated actions. ( Asaithambi, K; Jayaram, P; Medhamurthy, R; Tripathy, S, 2016)
"We determined whether androgen deficiency induced by flutamide treatment during mid- and late pregnancy affects the functions of the porcine corpus luteum (CL)."3.80Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum. ( Ciereszko, RE; Golas, A; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M; Wieciech, I, 2014)
"Time-mated Sprague-Dawley female rats were injected subcutaneously with flutamide (75 mg/kg in sunflower oil) on days 16 to 19 of pregnancy."3.75The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development. ( Balic, A; Buraundi, S; Farmer, P; Hutson, J; Nation, T; Newgreen, D; Southwell, B, 2009)
"The incidence of hypospadias increased with the dose of flutamide (0, 29."3.73[Impact of flutamide on sex differentiation in rats]. ( Li, Y; Liang, Y; Wang, WD; Wu, DS; Zhang, H, 2006)
" A total of 59 subjects (5-8 per treatment group) received exogenous androgen (testosterone enanthate), an anti-androgen (flutamide) or vehicle injections (DMSO) for 30 or 35 days during the second (early) or third (late) trimester of pregnancy."3.73Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: life history differences and effects of prenatal androgens. ( Gouzoules, H; Tomaszycki, ML; Wallen, K, 2005)
" Pregnant females received daily injections of the androgen receptor antagonist flutamide from day 12 of pregnancy until pups were born."3.73Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats. ( Camacho, FJ; Domínguez-Salazar, E; Paredes, RG, 2005)
"We investigated whether gestational age of in utero low-protein diet played a role in the subsequent development of adult hypertension and whether it is gender dependent and examined whether flutamide (a specific, nonsteroidal competitive antagonist of the androgen receptor) reduces blood pressure in rat offspring that are exposed to in utero low-protein diet (6%)."3.73Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero. ( Gangula, PR; Reed, L; Yallampalli, C, 2005)
"To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology."3.72[A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004)
"The role of prenatal androgen on the differentiation of sexually dimorphic juvenile play and adult copulatory patterns was evaluated in male offspring of rats injected with 5 mg of the androgen receptor blocker flutamide (4'-nitro-3'-trifluoromethylisobutyranilide) from Days 11-21 of pregnancy."3.72Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide. ( Bartke, A; Casto, JM; Ward, OB, 2003)
"The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring."3.72Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004)
"Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls."3.72Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004)
" Pregnant females received exogenous androgen (testosterone enanthate), an androgen antagonist (flutamide), or vehicle injections for 30 or 35 days during the second (early) or third (late) trimester of pregnancy."3.71Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens. ( Davis, JE; Gouzoules, H; Tomaszycki, ML; Wallen, K, 2001)
" The second experimental group of rats were given flutamide (10 mg/100 g) for ten days during pregnancy."3.70The effects of sialoadenectomy & flutamide on skin development. ( Inalöz, HS; Inalöz, SS; Ketani, MA; Ketani, S; Yilmaz, F, 2000)
" Treatment of pregnant females with flutamide and finasteride also markedly reduced circulating concentrations of testosterone and dihydrotestosterone in maternal plasma during pregnancy."3.70Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 2. Effects of prenatal anti-androgens. ( Coscia, EM; Drea, CM; Forger, NG; Frank, LG; Glickman, SE; Licht, P; Weldele, ML, 1998)
"Studies were undertaken to determine whether the anti-androgen, hydroxyflutamide, has anti-progestagenic activity by using implantation, maintenance of pregnancy, and decidualization as end points."3.68Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide. ( Armstrong, DT; Chandrasekhar, Y; Kennedy, TG, 1990)
" Female Wistar (W) and Sprague-Dawley (SD) rats were exposed to the anti-androgen flutamide prenatally (days 11-22 of pregnancy) and/or neonatally (days 1-10)."3.68Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats. ( Brand, T; Slob, AK, 1991)
"Flutamide was injected into pregnant gilts between Days 80 and 88 of gestation and into female piglets between Days 2 and 10 postnatally."2.77Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure. ( Duda, M; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M, 2012)
"Flutamide was given in five doses (50 mg/kg bw)."2.76Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment. ( Bilinska, B; Duda, M; Durlej, M; Hejmej, A; Knapczyk-Stwora, K; Kopera, I; Slomczynska, M, 2011)
"Acne vulgaris is a common reason why adult women present to dermatologists and can be a clinical challenge to treat."2.48Acne in the adult female patient: a practical approach. ( Kamangar, F; Shinkai, K, 2012)
"Testicular ectopy, unlike cryptorchidism, was associated with a short gubernacular ligament only."1.62Morphologic alterations of the genital mesentery implicated in testis non-descent in rats prenatally exposed to flutamide. ( Chrousos, G; Kanaka-Gantenbein, C; Kostakis, A; Mentessidou, A; Mirilas, P; Salakos, C, 2021)
"Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients."1.51Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy. ( Gong, H; Kuang, H; Li, Y; Ling, Y; Liu, H; Qiao, B; Wu, W; Xu, J; Yang, B; Yu, D, 2019)
"Our results demonstrated cryptorchidism models induced noticeable decreased fertility, significantly reduced sperm count, increased sperm abnormality rate, decreased testosterone and severe testicular damage in histomorphology."1.48Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy. ( He, DW; Lin, T; Liu, B; Long, CL; Shen, LJ; Tang, XL; Wei, GH; Wei, Y; Wu, SD; Zhou, Y, 2018)
" A non-monotonic dose-response relationship was not evident."1.46Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats. ( Buesen, R; Fussell, KC; Gröters, S; Jiang, X; Melching-Kollmuss, S; Schneider, S; Strauss, V; van Ravenzwaay, B, 2017)
"Flutamide was injected into pregnant gilts between days 80 and 88 of gestation and into female piglets between days 2 and 10 post-natally."1.43Effect of Prenatal and Neonatal Anti-Androgen Flutamide Treatment on Aquaporin 5 Expression in the Adult Porcine Ovary. ( Grzesiak, M; Knapczyk-Stwora, K; Luck, MR; Mobasheri, A; Slomczynska, M, 2016)
"Flutamide treatment (10 mg/kg/day subcutaneously for 10 days) reduced mean arterial pressure in protein-restricted offspring but was without significant effect in controls."1.42Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring. ( Balakrishnan, MP; Sathishkumar, K; Yallampalli, C, 2015)
"Flutamide treatment increased circulating testosterone yet also reduced seminal vesicle weight due to local antagonism of androgen receptor."1.42Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action. ( Cruickshanks, L; McKinnell, C; Milne, L; Mitchell, RT; Mungall, W; Sharpe, RM; Smith, LB, 2015)
"Flutamide treatment increased the expression of BMP4 mRNA on GD50 and GD108 and BMPR-IB mRNA on GD50."1.40TGFβ (transforming growth factor β) superfamily members and their receptors in the fetal porcine ovaries: effect of prenatal flutamide treatment. ( Duda, M; Galas, J; Grzesiak, M; Knapczyk-Stwora, K; Koziorowski, M; Slomczynska, M, 2014)
"Flutamide was injected subcutaneously into pregnant SD rats on gestational days 12-21 (25 mg/kg/day)."1.40Connexin 43 expression in Sprague-Dawley rat seminiferous epithelium after in utero exposure to flutamide. ( Cai, C; He, D; Ma, C; Wei, G; Wu, X; Zhang, Y; Zhao, D, 2014)
"No cryptorchidism was found in group A; unilateral cryptorchidism was seen in groups B (10."1.39[Expression of insulin-like factor 3 in the testis of flutamide-induced cryptorchidism mice and its significance]. ( Bai, C; Yuan, YM; Zhang, C; Zheng, M; Zhou, XJ, 2013)
"Flutamide was injected into pregnant gilts between days 80 and 88 of gestation, and into female piglets between days 2 and 10 postnatally."1.38Prenatal and neonatal flutamide administration increases proliferation and reduces apoptosis in large antral follicles of adult pigs. ( Durlej, M; Knapczyk-Stwora, K; Slomczynska, M, 2012)
"Since the majority of testicular cancers are derived from germ cells at the stage of transformation of primordial germ cell (PGC) into gonocytes, the increase has been attributed to maternal/fetal exposures to environmental factors."1.38Fetal radiation exposure induces testicular cancer in genetically susceptible mice. ( Comish, PB; Matin, A; Meistrich, ML; Shetty, G; Weng, CC, 2012)
"A rat model of Flu-induced cryptorchidism with remaining Gos was successfully established, which could be used to study the mechanism and management of the maldevelopment of cryptorchidism gonocytes."1.37[Establishment of a rat model of flutamide-induced cryptorchidism with remaining gonocytes]. ( He, DW; He, WF; Ma, C; Wei, GH; Zhang, YB; Zhao, D, 2011)
"Flutamide was injected into pregnant gilts between days 80 and 88 of gestation and into female piglets between days 2 and 10 posnatally."1.37Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin 43 gene expression in adult porcine ovary. ( Bilinska, B; Duda, M; Durlej, M; Hejmej, A; Knapczyk-Stwora, K; Kopera-Sobota, I; Slomczynska, M, 2011)
"Flutamide treated rats presented reductions in weight of testes and prostate, percentage of normal spermatozoa, spermatozoa concentration, testicular sperm production, and testosterone level."1.37Copulatory efficiency and fertility in male rats exposed perinatally to flutamide. ( Garcia, PC; Leonelli, C; Pereira, OC, 2011)
"Flutamide-treated rats (D2) showed the gubernaculum surrounded by a persisting breast bud."1.36Hidden in plain sight: the mammary line in males may be the missing link regulating inguinoscrotal testicular descent. ( Balic, A; Buraundi, S; Farmer, P; Hutson, J; Nation, T; Newgreen, D; Southwell, B, 2010)
"Flutamide was associated with higher levels of organized collagen and increased aggrecan expression with a greater proportion of chondroitin/dermatan sulfate glycosaminoglycans."1.35Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis. ( Chien, EK; Dailey, TL; Ji, H; Long, V, 2008)
" The aim was to assess whether the joint effects of vinclozolin, flutamide, and procymidone can be predicted based on dose-response data of the individual chemicals."1.34Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures. ( Axelstad, M; Christiansen, S; Dalgaard, M; Hass, U; Kiersgaard, MK; Kortenkamp, A; Metzdorff, SB; Scholze, M; Vinggaard, AM, 2007)
" Changes in anogenital distance (AGD) and nipple retention (NR) in male offspring rats were chosen as end points for extensive dose-response studies."1.34Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat. ( Axelstad, M; Christiansen, S; Dalgaard, M; Hass, U; Kortenkamp, A; Metzdorff, SB; Scholze, M; Vinggaard, AM, 2007)
"In flutamide-treated rats, DNA synthesis was suppressed until day 6, similar suppression was observed in capsaicin-treated SD, and TS rats until day 4."1.33Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve. ( Bidarkar, SS; Donath, S; Farmer, PJ; Hutson, JM; Ng, SL; Sourial, M, 2005)
"Flutamide is a drug with antiandrogen effects that are mediated through androgen receptors (ARs)."1.33Evaluation of general behavior, memory, learning performance, and brain sexual differentiation in F1 offspring males of rats treated with flutamide during late gestation. ( Fujii, Y; Goto, K; Hashi, M; Koizumi, K; Ohbo, N; Ohta, Y; Saika, O; Saito, K; Suzuki, H; Suzuki, K, 2005)
"Flutamide treatment impaired differentiation of inner stromal cells, shown by decreased expression of smooth muscle actin, before effects were noted in the epithelium, consistent with androgens driving WD development via stromal-epithelial interactions."1.33Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide. ( Marchetti, NI; Saunders, PT; Sharpe, RM; Welsh, M, 2006)
" Furthermore, these data suggest that dose-response studies utilizing late gestational exposure to endocrine-active compounds may be more robust than the traditional or EPA-modified multigeneration protocols in identifying adverse effects."1.31Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. ( Barlow, NJ; Foster, PM; Gaido, KW; Maness, SC; McIntyre, BS; Wallace, DG, 2000)
" The objectives of this study were to determine whether in utero exposure to flutamide results in permanent changes in male AGD and nipple retention, characterize the dose-response relationship between flutamide-mediated alterations in these landmarks and clearly adverse antiandrogenic effects, and establish the predictive value and relationship between AGD and nipple retention, and other adverse manifestations."1.31Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. ( Barlow, NJ; Foster, PM; McIntyre, BS, 2001)
"Flutamide, which has antiandrogenic properties, was administered to pregnant rats, and effects on male offspring were examined."1.31Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats. ( Matsuo, M; Miyata, K; Nakanishi, T; Okuno, Y; Sano, M; Sukata, T; Yabushita, S; Yoshino, H, 2002)
"Flutamide and tamoxifen treatment both suppressed FSH secretion at either age examined (p < 0."1.30Direct actions of gonadal steroid hormones on FSH secretion and expression in the infantile female rat. ( Handa, RJ; Wilson, ME, 1998)
" The chemical was dosed by gavage to pregnant dams at 10 or 100 mg/kg body wt from gestation day 14 to 18."1.30Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE. ( Archibeque-Engle, S; Casanova, M; Fan, LQ; Heck, HA; Sar, M; You, L, 1998)
"Flutamide treatment resulted in higher basal levels of testosterone and stress levels of corticosterone compared to vehicle treatment, and there was no interaction of treatment with age at time of treatment."1.30Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats. ( Mahoney, E; McCormick, CM, 1999)
" Pregnant Long-Evans rats were dosed by gavage from Gestation Day 14 to 18 at 0, 10 (low dose), or 100 (high dose) mg DDE, or 40 mg flutamide/kg body wt (bw)/day (in utero treatment)."1.30In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation. ( Brenneman, KA; Heck, H; You, L, 1999)
"The flutamide treatment had little effect on CYP enzyme expression."1.30Modulation of testosterone-metabolizing hepatic cytochrome P-450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p'-DDE. ( Archibeque-Engle, S; Bruce, JM; Casanova, M; Chan, SK; Corton, JC; Heck, H; You, L, 1999)
"Hydroxyflutamide is a potent nonsteroidal anti-androgenic drug extensively used in laboratory investigations."1.29Influence of the anti-androgen hydroxyflutamide on in vitro development of mouse embryos. ( Nagamani, M; Osuamkpe, C; Yallampalli, C, 1993)
"The decrease in undescended testes and epididymal abnormalities following epidermal growth factor treatment was significant at p < 0."1.29Epidermal growth factor reverses antiandrogen induced cryptorchidism and epididymal development. ( Cain, MP; Husmann, DA; Kramer, SA; Tindall, DJ, 1994)
" Dose-response studies were performed on male rats treated in utero during the period of sexual differentiation with either the potent 5 alpha-reductase inhibitor finasteride or the antiandrogen flutamide."1.28Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies. ( Imperato-McGinley, J; Sanchez, RS; Spencer, JR; Vaughan, ED; Yee, B, 1992)
"Cryptorchidism was enhanced when rats were treated postnatally with testosterone or oestradiol."1.28Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide. ( van der Schoot, P, 1992)
"Flutamide-treated males also had proportionately more large neurons than control males but fewer than females."1.28Prenatal flutamide alters sexually dimorphic nuclei in the spinal cord of male rats. ( Casto, JM; Grisham, W; Kashon, ML; Ward, IL; Ward, OB, 1992)
"Treatment with flutamide on days 14-20 of gestation resulted in hypospadias, the absence or only rudimentary growth of prostate and seminal vesicles, and the presence of a vagina in male offspring."1.27Inhibition of development of both androgen-dependent and androgen-independent pigment cells in scrotal skin dermis of the rat by antiandrogen treatment during fetal growth. ( Wilson, MJ, 1983)
" However, they were no less receptive than control females in response to a high (15 micrograms/kg) dosage of EB."1.27Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes. ( Baum, MJ; Tobet, SA, 1986)
"Flutamide treatment decreased the weight of accessory sex organs, stimulated the secretion of both LH (+200%) and FSH (+63%) by inhibition of the negative feedback of testosterone; endogenous testosterone secretion was increased by 363%."1.27Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan. ( Hochereau-de Reviers, MT; Perreau, C; Viguier-Martinez, MC, 1985)
"Treatment with cyproterone acetate at diestrus caused a decrease in the number of small follicles (less than 200 micrometer), freshly formed corpora lutea and the levels of estradiol-17beta in the ovary, suggesting inhibition of ovulation."1.26Evidence for a role of androgens in the growth and maturation of ovarian follicles in rats. ( Datta, JK; Kumari, GL; Roy, S, 1978)
" Males exposed prenatally to either the 1- or 5-mg dosage of flutamide exhibited significantly higher lordosis quotients than controls when given EB alone."1.26Androgenic influences on feminine sexual behavior in male and female rats: defeminization blocked by prenatal antiandrogen treatment. ( Clemens, LG; Gladue, BA, 1978)

Research

Studies (203)

TimeframeStudies, this research(%)All Research%
pre-199018 (8.87)18.7374
1990's39 (19.21)18.2507
2000's64 (31.53)29.6817
2010's70 (34.48)24.3611
2020's12 (5.91)2.80

Authors

AuthorsStudies
Drea, CM5
Davies, CS1
Greene, LK1
Mitchell, J1
Blondel, DV1
Shearer, CL1
Feldblum, JT1
Dimac-Stohl, KA1
Smyth-Kabay, KN1
Clutton-Brock, TH1
Vancolen, S1
Ayash, T1
Segura, M1
Allard, MJ1
Robaire, B1
Sébire, G1
Kemahli, E1
Uyeturk, U2
Cetinkaya, A1
Erimsah, S1
Gucuk, A1
Schreiber, E2
Garcia, T1
González, N1
Esplugas, R1
Sharma, RP1
Torrente, M2
Kumar, V2
Bovee, T2
Katsanou, ES2
Machera, K2
Domingo, JL2
Gómez, M1
Wang, S1
Lawless, J1
Zheng, Z1
Yu, H2
Wen, K3
Zhou, X3
Zhang, Y4
Yan, Z2
Fu, H2
Zhu, J2
Zhu, Y3
Batakis, P1
Spyropoulou, A1
Gómez, MM1
Mentessidou, A1
Salakos, C1
Chrousos, G1
Kanaka-Gantenbein, C1
Kostakis, A1
Mirilas, P1
Mirdamadi, M1
Kothencz, A1
Szűcs, E1
Benyhe, S1
Szécsi, M1
Gáspár, R1
Landers, RSM1
Padmanabhan, V7
Cardoso, RC3
Rolon, S1
Huynh, C1
Guenther, M1
Gardezi, M1
Phillips, J1
Gehrand, AL1
Raff, H1
Zacharia, LC1
Huber, SE2
Zoicas, I1
Reichel, M1
Mühle, C1
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Ekici, AB1
Eulenburg, V1
Lenz, B2
Kornhuber, J2
Müller, CP2
Schneider, S1
Fussell, KC1
Melching-Kollmuss, S1
Buesen, R1
Gröters, S1
Strauss, V1
Jiang, X1
van Ravenzwaay, B1
Czaja, E1
Wieciech-Rojkiewicz, I1
Knapczyk-Stwora, K21
Grzesiak, M14
Slomczynska, M20
Wei, Y1
Zhou, Y2
Tang, XL1
Liu, B2
Shen, LJ1
Long, CL1
Lin, T2
He, DW2
Wu, SD1
Wei, GH2
Olatunji, LA2
Areola, ED2
Badmus, OO2
Usman, TO1
Kim, I1
Yang, J1
Gong, H1
Wu, W1
Xu, J1
Yu, D1
Qiao, B1
Liu, H1
Yang, B1
Li, Y3
Ling, Y1
Kuang, H1
Zhang, D1
Hu, D1
Peng, J1
Shen, L1
Long, C1
Yu, Y1
Liu, X1
Tao, X1
Timashev, P1
He, D2
Wei, G2
Harada, N1
Yotsumoto, Y1
Katsuki, T1
Yoda, Y1
Masuda, T1
Nomura, M1
Shiraki, N1
Inui, H1
Yamaji, R1
Durlej-Grzesiak, M2
Ciereszko, RE3
Koziorowski, M4
Duda, M7
Wieciech, I5
Golas, A2
Yuan, YM1
Zhang, C1
Bai, C1
Zheng, M1
Zhou, XJ1
Cai, C1
Zhao, D2
Ma, C2
Wu, X1
Pike, JW1
McDowell, E1
McCahan, SM1
Johnson, KJ1
Pallarés, ME1
Adrover, E1
Imsen, M1
González, D1
Fabre, B1
Mesch, V1
Baier, CJ1
Antonelli, MC1
Roselli, CE2
Reddy, RC1
Estill, CT2
Scheldrup, M1
Meaker, M2
Stormshak, F2
Montilla, HJ1
Mitchell, RT1
Mungall, W1
McKinnell, C2
Sharpe, RM7
Cruickshanks, L1
Milne, L1
Smith, LB2
Galas, J2
Blesson, CS1
Chinnathambi, V1
Hankins, GD1
Yallampalli, C4
Sathishkumar, K2
Balakrishnan, MP1
Abi Salloum, B3
Veiga-Lopez, A5
Abbott, DH1
Burant, CF1
Pytlik, A1
Słomczynska, M2
Herkimer, C2
Moeller, J3
Beckett, E2
Sreedharan, R1
Mitan, A1
Janik, ME1
Yang, F1
Ruan, YC1
Yang, YJ1
Wang, K1
Liang, SS1
Han, YB1
Teng, XM1
Yang, JZ1
Belej, A1
Pease, A1
Keller, E1
Madrigal, V1
Chazenbalk, G1
Dumesic, D1
Luck, MR1
Mobasheri, A1
Gibson, DA1
Simitsidellis, I1
Cousins, FL1
Critchley, HO1
Saunders, PT3
Tripathy, S1
Asaithambi, K1
Jayaram, P1
Medhamurthy, R1
Dasinger, JH1
Intapad, S1
Rudsenske, BR1
Davis, GK1
Newsome, AD1
Alexander, BT1
Kita, DH1
Meyer, KB1
Venturelli, AC1
Adams, R1
Machado, DL1
Morais, RN1
Swan, SH1
Gennings, C1
Martino-Andrade, AJ1
Burns, A1
Skinner, DC1
Anway, MD2
Rekow, SS1
Skinner, MK2
Brokken, LJ2
Adamsson, A1
Paranko, J2
Toppari, J2
Moon, HJ1
Kang, TS2
Kim, TS2
Kang, IH2
Ki, HY1
Kim, SH1
Han, SY2
Inawaka, K1
Kawabe, M1
Takahashi, S1
Doi, Y1
Tomigahara, Y1
Tarui, H1
Abe, J1
Kawamura, S1
Shirai, T1
Vallcaneras, SS1
Casais, M1
Delgado, SM1
Filippa, V1
Mohamed, F1
Sosa, Z1
Rastrilla, AM1
Welsh, M5
MacLeod, DJ2
Walker, M1
Durlej, M6
Kopera, I3
Hejmej, A4
Bilinska, B6
Fisken, M1
Scott, HM3
Hutchison, GR2
Drake, AJ1
van den Driesche, S1
Nation, T2
Balic, A4
Buraundi, S4
Farmer, P3
Newgreen, D3
Southwell, B2
Hutson, J2
Auharek, SA1
de Franca, LR1
Jobling, MS1
Johansen, JA1
Troxell-Smith, SM1
Yu, Z1
Mo, K1
Monks, DA1
Lieberman, AP1
Breedlove, SM2
Jordan, CL1
Jung, KK1
Kim, SS1
Baek, JH1
Nam, HS1
Hong, SK1
Lee, BM1
Hong, JT1
Oh, KW1
Kim, HS1
Leonelli, C1
Garcia, PC1
Pereira, OC1
Kopera-Sobota, I2
Place, NJ3
Coscia, EM4
Dahl, NJ1
Holekamp, KE2
Roser, JF1
Sisk, CL2
Weldele, ML4
Glickman, SE4
Lydka, M2
Kotula-Balak, M2
Chojnacka, K1
Zak, D1
He, WF1
Zhang, YB1
Nantia, EA1
Manfo, PF1
Beboy, NE1
Travert, C1
Carreau, S1
Monsees, TK1
Moundipa, PF1
Luense, LJ1
Christenson, LK1
Nation, TR1
Farmer, PJ3
Southwell, BR3
Hutson, JM6
Chen, N1
Harisis, GN1
Sourial, M3
Shetty, G1
Comish, PB1
Weng, CC1
Matin, A1
Meistrich, ML1
Lee, JS1
Kamangar, F1
Shinkai, K1
Guerrero-Bosagna, C1
Covert, TR1
Haque, MM1
Settles, M1
Nilsson, EE1
Licht, P2
Clark, AS1
Kelton, MC1
Whitney, AC1
Omezzine, A1
Chater, S2
Mauduit, C4
Florin, A3
Tabone, E3
Chuzel, F3
Bars, R3
Benahmed, M4
Herman, RA3
Measday, MA1
Wallen, K8
Goddard, I1
Contard, P1
Casto, JM2
Ward, OB2
Bartke, A1
Miyata, K2
Yabushita, S2
Sano, M2
Miyashita, K1
Okuno, Y2
Matsuo, M2
Källén, B1
Ko, K1
Theobald, HM1
Moore, RW1
Peterson, RE1
He, H1
Zhang, W1
Lu, SY1
Liao, JW1
Kuo, ML1
Wang, SC1
Hwang, JS1
Ueng, TH1
Bozec, A2
Paulin, C1
Zehr, JL2
Van Meter, PE1
Wewers, D1
Kaiser, S1
Sachser, N1
Yamasaki, K1
Noda, S1
Muroi, T1
Mitoma, H1
Takakura, S1
Sakamoto, S1
Goto, K2
Koizumi, K2
Takaori, H1
Fujii, Y2
Furuyama, Y1
Saika, O2
Suzuki, H2
Saito, K2
Suzuki, K2
Gangula, PR1
Reed, L1
Ng, SL1
Bidarkar, SS1
Donath, S1
Perusquía, M1
Navarrete, E1
Jasso-Kamel, J1
Montaño, LM1
Brännvall, K1
Bogdanovic, N1
Korhonen, L1
Lindholm, D1
Foster, PM5
Harris, MW1
Heikkilä, M1
Prunskaite, R1
Naillat, F1
Itäranta, P1
Vuoristo, J1
Leppäluoto, J1
Peltoketo, H1
Vainio, S1
Domínguez-Salazar, E2
Camacho, FJ1
Paredes, RG2
Ohta, Y1
Hashi, M1
Ohbo, N1
Tomaszycki, ML2
Gouzoules, H2
Veeramachaneni, DN1
Zhang, H2
Wang, WD1
Liang, Y2
Wu, DS2
McFadden, D1
Pasanen, EG1
Raper, J1
Lange, HS1
Marchetti, NI1
Mahood, IK1
Hallmark, N1
De Gendt, K1
Verhoeven, G1
O'Shaughnessy, P1
Metzdorff, SB2
Dalgaard, M2
Christiansen, S2
Axelstad, M2
Hass, U2
Kiersgaard, MK1
Scholze, M2
Kortenkamp, A2
Vinggaard, AM2
Orlando, R1
Caruso, A1
Molinaro, G1
Motolese, M1
Matrisciano, F1
Togna, G1
Melchiorri, D1
Nicoletti, F1
Bruno, V1
Foradori, CD1
Werner, SB1
Sandau, US1
Clapp, TR1
Handa, RJ2
Adamsson, NA1
Harnaen, EJ1
Na, AF1
Shenker, NS1
Benbrahim-Tallaa, L1
Siddeek, B1
Tronchon, V1
Friry, C1
Ji, H1
Dailey, TL1
Long, V1
Chien, EK1
Seifert, AW1
Harfe, BD1
Cohn, MJ1
Gray, DS1
Gorzalka, BB1
Taylor, GT1
Haller, J1
Rupich, R1
Weiss, J1
Erskine, MS2
Arnold, AP1
Wilson, MJ1
Nielsen, HC1
Zinman, HM1
Torday, JS1
Marcus, JI1
Baum, MJ3
Cain, MP4
Kramer, SA4
Tindall, DJ4
Husmann, DA7
Bentvelsen, FM2
McPhaul, MJ3
Wilson, JD1
George, FW1
Shono, T4
Osuamkpe, C1
Nagamani, M1
Lephart, ED5
Keisler, LW2
vom Saal, FS2
Keisler, DH2
Rudeen, PK1
Walker, SE2
Hib, J1
Ponzio, R1
Hanley, K1
Rassner, U1
Jiang, Y1
Vansomphone, D1
Crumrine, D1
Komüves, L1
Elias, PM1
Feingold, KR1
Williams, ML1
Brinkmann, AO1
van der Schoot, P2
van der Linden, JE1
van der Kwast, TH1
Boersma, WJ1
Schröder, FH1
Nijman, JM1
Silversides, DW1
Price, CA1
Cooke, GM1
Tarasenko, LV1
Sinitsyn, PV1
Reznikov, AG1
Watts, L1
Goh, DW1
Momose, Y1
Middlesworth, B1
Zhou, B1
Ramm-Anderson, S1
Thordarson, G1
Galosy, S1
Gudmundsson, GO1
Newcomer, B1
Sridaran, R1
Talamantes, F1
Poletti, A1
Negri-Cesi, P1
Rabuffetti, M1
Colciago, A1
Celotti, F1
Martini, L1
Wilson, ME1
Forger, NG1
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Watson, MA1
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You, L3
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Archibeque-Engle, S2
Sar, M3
Fan, LQ1
Heck, HA1
McCormick, CM1
Mahoney, E1
Mylchreest, E1
Cattley, RC1
Gornstein, RA1
Lapp, CA1
Bustos-Valdes, SM1
Zamorano, P1
Chan, SK1
Bruce, JM1
Corton, JC1
Heck, H2
Axelson, JF1
Smith, M1
Duarte, M1
Brenneman, KA1
Lund, TD3
Salyer, DL2
Fleming, DE2
McIntyre, BS2
Barlow, NJ2
Wallace, DG1
Maness, SC1
Gaido, KW2
Lonstein, JS1
De Vries, GJ1
Zakaria, O2
Imajima, T2
Suita, S2
Horvath, TL1
Inalöz, HS1
Ketani, MA1
Inalöz, SS1
Yilmaz, F1
Ketani, S1
Kai, H1
Davis, JE1
Shultz, VD1
Phillips, S1
Portillo, W1
Bakker, J1
Sukata, T1
Yoshino, H1
Nakanishi, T1
Kumari, GL1
Datta, JK1
Roy, S1
Gladue, BA1
Clemens, LG2
Imperato-McGinley, J2
Sanchez, RS2
Spencer, JR2
Yee, B1
Vaughan, ED2
Levine, AC1
Ren, M1
Huber, GK1
Kirschenbaum, A1
Grisham, W1
Kashon, ML1
Ward, IL1
Torrado, T1
Thornton, JE1
Irving, S1
Goy, RW1
Brand, T2
Slob, AK2
Chandrasekhar, Y1
Armstrong, DT1
Kennedy, TG1
Melvin, JE1
Hamill, RW1
Winneker, RC1
Wagner, MM1
Batzold, FH1
Sayag, N1
Snapir, N1
Robinzon, B1
Arnon, E1
el Halawani, ME1
Grimm, VE1
Yun, YW1
Yuen, BH1
Moon, YS1
Tate-Ostroff, BA1
Bridges, RS1
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Tobet, SA1
Viguier-Martinez, MC1
Hochereau-de Reviers, MT1
Perreau, C1
Dohanich, GP1
Witcher, JA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967]Phase 430 participants (Anticipated)Interventional2021-04-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for flutamide and Pregnancy

ArticleYear
Permitted Daily Exposure of the Androgen Receptor Antagonist Flutamide.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 10-01, Volume: 159, Issue:2

    Topics: Administration, Oral; Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug;

2017
Acne in the adult female patient: a practical approach.
    International journal of dermatology, 2012, Volume: 51, Issue:10

    Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatologic

2012
Hormonal influences on sexually differentiated behavior in nonhuman primates.
    Frontiers in neuroendocrinology, 2005, Volume: 26, Issue:1

    Topics: Androgen Antagonists; Androgens; Animals; Behavior, Animal; Female; Flutamide; Genitalia, Female; Ho

2005
Adrenal steroid interactions in female sexual behavior : a review.
    Psychoneuroendocrinology, 1980, Volume: 5, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenalectomy; Adrenocorticotropic Hormone; Androgens; Animals; Castration;

1980

Trials

4 trials available for flutamide and Pregnancy

ArticleYear
Alterations in luteal production of androstenedione, testosterone, and estrone, but not estradiol, during mid- and late pregnancy in pigs: effects of androgen deficiency.
    Theriogenology, 2014, Sep-15, Volume: 82, Issue:5

    Topics: 17-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Androstenedione; Animals; Aromatase; Corpus

2014
Morphological and functional alterations in adult boar epididymis: Effects of prenatal and postnatal administration of flutamide.
    Acta veterinaria Scandinavica, 2011, Feb-22, Volume: 53

    Topics: Androgen Antagonists; Animals; Connexin 43; Drug Administration Schedule; Epididymis; Female; Flutam

2011
Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment.
    Reproduction in domestic animals = Zuchthygiene, 2011, Volume: 46, Issue:6

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Female; Flutamide; Gene Expression Reg

2011
Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure.
    Theriogenology, 2012, Volume: 78, Issue:9

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Aromatase; beta Catenin; Estradiol; Female; Flutami

2012

Other Studies

195 other studies available for flutamide and Pregnancy

ArticleYear
An intergenerational androgenic mechanism of female intrasexual competition in the cooperatively breeding meerkat.
    Nature communications, 2021, 12-17, Volume: 12, Issue:1

    Topics: Aggression; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Animals, Wild; Breeding; Com

2021
Androgens Upregulate Pathogen-Induced Placental Innate Immune Response.
    International journal of molecular sciences, 2022, Apr-29, Volume: 23, Issue:9

    Topics: Androgens; Chorioamnionitis; Female; Flutamide; Humans; Immunity, Innate; Male; Placenta; Pregnancy;

2022
Protective Effects of N-Acetyl Cysteine on Undescended Testis after Orchiopexy: A Rat-model Study.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2023, Volume: 33, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Cryptorchidism; Female; Flutamide; Humans; Male; Orchiopexy;

2023
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 139

    Topics: Animals; Animals, Newborn; Cryptorchidism; Dienestrol; Dose-Response Relationship, Drug; Endpoint De

2020
Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs†.
    Biology of reproduction, 2020, 05-26, Volume: 102, Issue:6

    Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Animals; Animals, Newborn; Cell Death; Cell Pr

2020
Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide.
    Human & experimental toxicology, 2020, Volume: 39, Issue:12

    Topics: Androgen Antagonists; Animals; Apoptosis; Autophagy; Female; Flutamide; Gene Expression; Male; Mice,

2020
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part II: Endocrine-related gene expression assessment on male offspring rat testes.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 144

    Topics: Animals; Cytochrome P-450 Enzyme System; Dienestrol; Female; Flutamide; Gene Expression Regulation;

2020
Morphologic alterations of the genital mesentery implicated in testis non-descent in rats prenatally exposed to flutamide.
    Andrology, 2021, Volume: 9, Issue:1

    Topics: Androgens; Animals; Cryptorchidism; Female; Flutamide; Genitalia, Male; Male; Mesentery; Pregnancy;

2021
Non-genomic actions of sex hormones on pregnant uterine contractility in rats: An in vitro study at term.
    Life sciences, 2020, Dec-15, Volume: 263

    Topics: Animals; Dose-Response Relationship, Drug; Estradiol; Female; Flutamide; Fulvestrant; Mifepristone;

2020
Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus.
    Reproductive biology and endocrinology : RB&E, 2020, Nov-07, Volume: 18, Issue:1

    Topics: Animals; Female; Fetal Development; Fetus; Flutamide; Hyperandrogenism; Luteinizing Hormone; Polycys

2020
Insulin and glucose responses to hypoxia in male and female neonatal rats: Effects of the androgen receptor antagonist flutamide.
    Physiological reports, 2021, Volume: 9, Issue:1

    Topics: Androgen Receptor Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Flutamide;

2021
Flutamide induces uterus and ovary damage in the mouse via apoptosis and excessive autophagy of cells following triggering of the unfolded protein response.
    Reproduction, fertility, and development, 2021, Volume: 33, Issue:7

    Topics: Androgen Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Relate

2021
Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way.
    Addiction biology, 2018, Volume: 23, Issue:3

    Topics: Alcohol Drinking; Androgen Receptor Antagonists; Androgens; Animals; Brain-Derived Neurotrophic Fact

2018
Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats.
    Archives of toxicology, 2017, Volume: 91, Issue:12

    Topics: Animals; Dose-Response Relationship, Drug; Estrous Cycle; Female; Flutamide; Imidazoles; Male; Nippl

2017
The impact of antiandrogen flutamide on the hypoxia inducible factor 1a and vascular endothelial growth factor A gene and protein expression in the pig placenta during late pregnancy.
    Folia histochemica et cytobiologica, 2017, Volume: 55, Issue:3

    Topics: Androgen Antagonists; Animals; Female; Flutamide; Gene Expression Regulation, Developmental; Hypoxia

2017
Prenatal androgen-receptor activity has organizational morphological effects in mice.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Animals; Body Size; Dihydrotestosterone; Extremities; Female; Flutamide; Functional Laterality; Gona

2017
Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy.
    Toxicology mechanisms and methods, 2018, Volume: 28, Issue:7

    Topics: Androgen Antagonists; Animals; Apoptosis; Autophagosomes; Autophagy; Biomarkers; Cryptorchidism; Die

2018
Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 107

    Topics: Androgen Antagonists; Animals; Antioxidants; Endoglin; Female; Flutamide; Glucosephosphate Dehydroge

2018
Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities.
    The Journal of nutritional biochemistry, 2018, Volume: 62

    Topics: Adenosine Deaminase; Androgen Receptor Antagonists; Animals; Animals, Newborn; Antioxidants; Female;

2018
[Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring].
    Wei sheng yan jiu = Journal of hygiene research, 2018, Volume: 47, Issue:6

    Topics: Animals; Female; Flutamide; Genitalia, Male; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Oxidativ

2018
Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy.
    PloS one, 2019, Volume: 14, Issue:5

    Topics: Androgen Antagonists; Animals; Decidua; Disease Models, Animal; Embryo Implantation; Female; Flutami

2019
Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro.
    Reproductive toxicology (Elmsford, N.Y.), 2019, Volume: 87

    Topics: Androgen Antagonists; Animals; Blood-Testis Barrier; Connexins; Cryptorchidism; Female; Flutamide; I

2019
Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats.
    American journal of physiology. Endocrinology and metabolism, 2019, 11-01, Volume: 317, Issue:5

    Topics: Androgen Antagonists; Androgens; Animals; Body Composition; Diabetes Mellitus, Type 2; Diet, High-Fa

2019
In utero exposure to the anti-androgen flutamide influences connexin 43 and β-catenin expression in porcine fetal gonads.
    Domestic animal endocrinology, 2013, Volume: 44, Issue:4

    Topics: Androgen Antagonists; Androgens; Animals; beta Catenin; Connexin 43; Female; Flutamide; Gene Express

2013
Antiandrogen flutamide affects folliculogenesis during fetal development in pigs.
    Reproduction (Cambridge, England), 2013, Mar-01, Volume: 145, Issue:3

    Topics: Androgen Antagonists; Animals; Apoptosis; Cadherins; Cell Proliferation; Female; Fetus; Flutamide; G

2013
Effect of flutamide on folliculogenesis in the fetal porcine ovary--regulation by Kit ligand/c-Kit and IGF1/IGF1R systems.
    Animal reproduction science, 2013, Nov-30, Volume: 142, Issue:3-4

    Topics: Androgen Antagonists; Animals; Female; Fetus; Flutamide; Gene Expression Regulation, Developmental;

2013
Flutamide influences placental aldo-keto reductase family 1 member C1 (AKR1C1) expression in pigs.
    Reproduction in domestic animals = Zuchthygiene, 2014, Volume: 49, Issue:1

    Topics: 20-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Aldo-Keto Reductases; Androgen Antagonists; An

2014
[Expression of insulin-like factor 3 in the testis of flutamide-induced cryptorchidism mice and its significance].
    Zhonghua nan ke xue = National journal of andrology, 2013, Volume: 19, Issue:11

    Topics: Animals; Cryptorchidism; Female; Flutamide; Insulin; Male; Maternal Exposure; Mice; Mice, Inbred BAL

2013
Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum.
    Reproductive sciences (Thousand Oaks, Calif.), 2014, Volume: 21, Issue:6

    Topics: Androgen Antagonists; Androgens; Animals; Corpus Luteum; Female; Flutamide; Pregnancy; Progesterone;

2014
Connexin 43 expression in Sprague-Dawley rat seminiferous epithelium after in utero exposure to flutamide.
    Systems biology in reproductive medicine, 2014, Volume: 60, Issue:5

    Topics: Androgen Antagonists; Animals; Connexin 43; Epithelium; Female; Flutamide; Male; Maternal Exposure;

2014
Identification of gene expression changes in postnatal rat foreskin after in utero anti-androgen exposure.
    Reproductive toxicology (Elmsford, N.Y.), 2014, Volume: 47

    Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Female; Flutamide; Foreskin; Gene Expression Regul

2014
Altered expression of 3β-HSD, CYP17 and 17β-HSD in the foetal porcine gonads in response to anti-androgen flutamide exposure.
    Reproduction in domestic animals = Zuchthygiene, 2014, Volume: 49, Issue:5

    Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Fe

2014
Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring.
    Neuroscience, 2014, Oct-10, Volume: 278

    Topics: Androgen Antagonists; Androgens; Animals; Body Weight; Brain; Female; Flutamide; Hippocampus; Male;

2014
Prenatal influence of an androgen agonist and antagonist on the differentiation of the ovine sexually dimorphic nucleus in male and female lamb fetuses.
    Endocrinology, 2014, Volume: 155, Issue:12

    Topics: Androgen Antagonists; Androgens; Animals; Dihydrotestosterone; Female; Flutamide; Hypothalamo-Hypoph

2014
Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.
    Endocrinology, 2015, Volume: 156, Issue:1

    Topics: Androgen Antagonists; Androgens; Animals; Biomarkers; Cohort Studies; Estrogens; Female; Flutamide;

2015
TGFβ (transforming growth factor β) superfamily members and their receptors in the fetal porcine ovaries: effect of prenatal flutamide treatment.
    Folia histochemica et cytobiologica, 2014, Volume: 52, Issue:4

    Topics: Androgen Antagonists; Animals; Bone Morphogenetic Protein 4; Female; Flutamide; Gene Expression Regu

2014
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:3

    Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug;

2015
Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring.
    Biology of reproduction, 2015, Volume: 92, Issue:2

    Topics: Androgen Antagonists; Angiotensin II; Animals; Female; Flutamide; Mesenteric Arteries; Pregnancy; Pr

2015
Developmental programming: exposure to testosterone excess disrupts steroidal and metabolic environment in pregnant sheep.
    Endocrinology, 2015, Volume: 156, Issue:6

    Topics: Animals; Birth Weight; Blood Glucose; Female; Flutamide; Insulin; Pregnancy; Progesterone; Reproduct

2015
Influence of the antiandrogen flutamide on connexin 43 (Cx43) gene and protein expression in the porcine placenta and uterus during pregnancy.
    Folia biologica, 2014, Volume: 62, Issue:4

    Topics: Androgen Antagonists; Animals; Connexin 43; Female; Flutamide; Gene Expression Regulation; Placenta;

2014
Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep.
    Endocrinology, 2015, Volume: 156, Issue:7

    Topics: Androgen Antagonists; Androgens; Animals; Estrous Cycle; Female; Fetal Development; Flutamide; Hypog

2015
Flutamide alters β-catenin expression and distribution, and its interactions with E-cadherin in the porcine corpus luteum of mid- and late pregnancy.
    Histology and histopathology, 2015, Volume: 30, Issue:11

    Topics: Androgen Antagonists; Animals; beta Catenin; Cadherins; Corpus Luteum; Female; Flutamide; Gene Expre

2015
Follicular hyperandrogenism downregulates aromatase in luteinized granulosa cells in polycystic ovary syndrome women.
    Reproduction (Cambridge, England), 2015, Volume: 150, Issue:4

    Topics: Adult; Androgen Antagonists; Aromatase; Cell Line; Down-Regulation; Female; Fertilization in Vitro;

2015
Effect of gestational antiandrogen treatment on Dicer1 expression in the porcine fetal gonads.
    Acta histochemica, 2015, Volume: 117, Issue:8

    Topics: Androgen Antagonists; Animals; Cytoplasm; Female; Fetus; Flutamide; Gene Expression; Male; Maternal-

2015
Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep.
    Endocrinology, 2016, Volume: 157, Issue:2

    Topics: Adiposity; Animals; Disease Models, Animal; Embryonic Development; Female; Flutamide; Insulin Resist

2016
Effect of Prenatal and Neonatal Anti-Androgen Flutamide Treatment on Aquaporin 5 Expression in the Adult Porcine Ovary.
    Reproduction in domestic animals = Zuchthygiene, 2016, Volume: 51, Issue:1

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Aquaporin 5; Female; Flutamide; Gene Expression; Im

2016
Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes.
    Scientific reports, 2016, Jan-28, Volume: 6

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Decidua; Endometrium; Female; Flutamide; Gene Expr

2016
Effects of Long-Term Flutamide Treatment During Development on Sexual Behaviour and Hormone Responsiveness in Rams.
    Journal of neuroendocrinology, 2016, Volume: 28, Issue:5

    Topics: Androgen Receptor Antagonists; Animals; Estradiol; Female; Flutamide; Gonadal Steroid Hormones; Gona

2016
Analysis of 17β-estradiol (E2) role in the regulation of corpus luteum function in pregnant rats: Involvement of IGFBP5 in the E2-mediated actions.
    Reproductive biology and endocrinology : RB&E, 2016, Apr-12, Volume: 14

    Topics: Anastrozole; Androgen Antagonists; Animals; Aromatase Inhibitors; Cell Proliferation; Corpus Luteum;

2016
Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted Rats.
    Hypertension (Dallas, Tex. : 1979), 2016, Volume: 67, Issue:6

    Topics: Animals; Animals, Newborn; Birth Weight; Blood Pressure Determination; Disease Models, Animal; Femal

2016
Manipulation of pre and postnatal androgen environments and anogenital distance in rats.
    Toxicology, 2016, Aug-10, Volume: 368-369

    Topics: Androgen Antagonists; Androgens; Animals; Diethylhexyl Phthalate; Disease Models, Animal; Dose-Respo

2016
Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS.
    Endocrinology, 2016, Volume: 157, Issue:12

    Topics: Androgen Antagonists; Androgens; Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; F

2016
Induction of autophagy in the porcine corpus luteum of pregnancy following anti-androgen treatment.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016, Volume: 67, Issue:6

    Topics: Androgen Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Corpus

2016
Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis.
    Reproductive toxicology (Elmsford, N.Y.), 2008, Volume: 26, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Dose-Response Relationship, Drug; Female; Flutamide; Ma

2008
Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis.
    Endocrinology, 2009, Volume: 150, Issue:1

    Topics: Androgen Antagonists; Animals; Cholesterol Side-Chain Cleavage Enzyme; DNA Primers; Female; Fetal De

2009
OECD validation of phase 3 Hershberger assay in Korea using surgically castrated male rats with coded chemicals.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:4

    Topics: Anabolic Agents; Androgen Antagonists; Androgens; Animals; Biological Assay; Body Weight; Dichlorodi

2009
Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations.
    Toxicology and applied pharmacology, 2009, Jun-01, Volume: 237, Issue:2

    Topics: Androgen Antagonists; Animals; Base Sequence; Bridged Bicyclo Compounds; DNA Methylation; Female; Fl

2009
Androgen receptors in coeliac ganglion in late pregnant rat.
    Steroids, 2009, Volume: 74, Issue:6

    Topics: 20-alpha-Hydroxysteroid Dehydrogenase; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Andros

2009
Critical androgen-sensitive periods of rat penis and clitoris development.
    International journal of andrology, 2010, Volume: 33, Issue:1

    Topics: Androgens; Animals; Clitoris; Female; Flutamide; Genitalia; Male; Penis; Pregnancy; Rats; Rats, Wist

2010
Connexin 43 gene expression in male and female gonads of porcine offspring following in utero exposure to an anti-androgen, flutamide.
    Acta histochemica, 2011, Volume: 113, Issue:1

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Female; Flutamide; Gene Expression; Im

2011
Androgen action in the masculinization programming window and development of male reproductive organs.
    International journal of andrology, 2010, Volume: 33, Issue:2

    Topics: Androgen Antagonists; Androgens; Animals; Animals, Newborn; Dibutyl Phthalate; Female; Flutamide; Ge

2010
The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development.
    Journal of pediatric surgery, 2009, Volume: 44, Issue:12

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Division; Cell Movement; Cryptorchidism; Disea

2009
Hidden in plain sight: the mammary line in males may be the missing link regulating inguinoscrotal testicular descent.
    Journal of pediatric surgery, 2010, Volume: 45, Issue:2

    Topics: Abdominal Wall; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Animals,

2010
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.
    Endocrinology, 2010, Volume: 151, Issue:6

    Topics: Animals; Dibutyl Phthalate; Female; Fetus; Flutamide; Immunohistochemistry; Male; Organ Size; Pregna

2010
Immunohistochemical studies on the proliferative marker Ki-67 and estrogen receptor alpha (ERα) in the uterus of neonatal and immature pigs following exposure to flutamide.
    Acta histochemica, 2011, Volume: 113, Issue:5

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Biomarkers; Cell Proliferation; Connective Tissue;

2011
The expression of FSH receptor (FSHR) in the neonatal porcine ovary and its regulation by flutamide.
    Reproduction in domestic animals = Zuchthygiene, 2011, Volume: 46, Issue:3

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Female; Flutamide; Follicle Stimulating Hormone; Ge

2011
Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy.
    Neuro-degenerative diseases, 2011, Volume: 8, Issue:1-2

    Topics: Alleles; Anatomy, Cross-Sectional; Androgen Antagonists; Animals; Behavior, Animal; Bulbo-Spinal Atr

2011
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:21-22

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht

2010
Copulatory efficiency and fertility in male rats exposed perinatally to flutamide.
    Reproductive toxicology (Elmsford, N.Y.), 2011, Volume: 31, Issue:1

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Copulation; Female; Fertility; Flutamide; Genitalia

2011
Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin 43 gene expression in adult porcine ovary.
    Domestic animal endocrinology, 2011, Volume: 40, Issue:1

    Topics: 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Corpu

2011
The anti-androgen combination, flutamide plus finasteride, paradoxically suppressed LH and androgen concentrations in pregnant spotted hyenas, but not in males.
    General and comparative endocrinology, 2011, Feb-01, Volume: 170, Issue:3

    Topics: Androgen Antagonists; Androstenedione; Animals; Estradiol; Feedback; Female; Finasteride; Flutamide;

2011
[Establishment of a rat model of flutamide-induced cryptorchidism with remaining gonocytes].
    Zhonghua nan ke xue = National journal of andrology, 2011, Volume: 17, Issue:3

    Topics: Animals; Cryptorchidism; Female; Flutamide; Male; Neural Cell Adhesion Molecules; Pregnancy; Rats; R

2011
Effect of methanol extract of Basella alba L. (Basellaceae) on the fecundity and testosterone level in male rats exposed to flutamide in utero.
    Andrologia, 2012, Volume: 44, Issue:1

    Topics: Androgen Receptor Antagonists; Animals; Female; Fertility; Fetus; Flutamide; Magnoliopsida; Male; Me

2012
Developmental programming: gestational testosterone treatment alters fetal ovarian gene expression.
    Endocrinology, 2011, Volume: 152, Issue:12

    Topics: Androgen Antagonists; Androgens; Animals; Estrogens; Female; Fetal Development; Flutamide; Gene Expr

2011
The effect of flutamide on expression of androgen and estrogen receptors in the gubernaculum and surrounding structures during testicular descent.
    Journal of pediatric surgery, 2011, Volume: 46, Issue:12

    Topics: Androgen Antagonists; Animals; Cell Nucleus; Cryptorchidism; Estrogen Receptor alpha; Estrogen Recep

2011
Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.
    Journal of pediatric surgery, 2011, Volume: 46, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Androgen Antagonists; Androgens; Animals; beta Catenin; Carrie

2011
Prenatal and neonatal exposure to flutamide affects function of Leydig cells in adult boar.
    Domestic animal endocrinology, 2012, Volume: 42, Issue:3

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Size; Estradiol; Female; Flutamide; Follicle S

2012
Fetal radiation exposure induces testicular cancer in genetically susceptible mice.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Androgen Antagonists; Animals; Diethylstilbestrol; Estrogens, Non-Steroidal; Female; Fetus; Flutamid

2012
Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep.
    Endocrinology, 2012, Volume: 153, Issue:6

    Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Estradiol; Estrogens; Feedback, Phys

2012
Prenatal and neonatal flutamide administration increases proliferation and reduces apoptosis in large antral follicles of adult pigs.
    Animal reproduction science, 2012, Volume: 132, Issue:1-2

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Apoptosis; Cell Growth Processes; Estradiol; Female

2012
Influence of the antiandrogen flutamide on the androgen receptor gene expression in the placenta and umbilical cord during pregnancy in the pig.
    Acta histochemica, 2013, Volume: 115, Issue:3

    Topics: Animals; Blotting, Western; Female; Flutamide; Gene Expression Regulation; Immunohistochemistry; Pla

2013
Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.
    Reproductive toxicology (Elmsford, N.Y.), 2012, Volume: 34, Issue:4

    Topics: Androgen Antagonists; Animals; Animals, Outbred Strains; Apoptosis; Biomarkers; DNA Methylation; End

2012
Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta.
    Biology of reproduction, 2002, Volume: 67, Issue:5

    Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Carnivora; Chorionic Gonadotropin; Female; Fi

2002
Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating.
    Proceedings. Biological sciences, 2002, Oct-07, Volume: 269, Issue:1504

    Topics: Androgen Antagonists; Androgens; Animals; Carnivora; Enzyme Inhibitors; Female; Finasteride; Flutami

2002
Chronic administration of anabolic steroids disrupts pubertal onset and estrous cyclicity in rats.
    Biology of reproduction, 2003, Volume: 68, Issue:2

    Topics: Anabolic Agents; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Body Weight; Drug Adm

2003
Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide.
    Endocrinology, 2003, Volume: 144, Issue:2

    Topics: Age Factors; Androgen Antagonists; Animals; Apoptosis; Caspase 3; Caspase 6; Caspases; Female; Fluta

2003
Sex differences in interest in infants in juvenile rhesus monkeys: relationship to prenatal androgen.
    Hormones and behavior, 2003, Volume: 43, Issue:5

    Topics: Age Factors; Analysis of Variance; Androgen Antagonists; Animals; Behavior, Animal; Female; Flutamid

2003
Alteration of lactate production and transport in the adult rat testis exposed in utero to flutamide.
    Molecular and cellular endocrinology, 2003, Aug-29, Volume: 206, Issue:1-2

    Topics: Androgen Antagonists; Animals; Biological Transport; Female; Flutamide; Isoenzymes; L-Lactate Dehydr

2003
Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide.
    Physiology & behavior, 2003, Volume: 79, Issue:4-5

    Topics: Androgen Antagonists; Animals; Copulation; Female; Flutamide; Genitalia, Male; Male; Play and Playth

2003
Effects of perinatal exposure to flutamide on sex hormone responsiveness in F1 male rats.
    The Journal of toxicological sciences, 2003, Volume: 28, Issue:3

    Topics: Androgen Antagonists; Androgens; Animals; Biological Assay; Female; Flutamide; Follicle Stimulating

2003
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:1

    Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna

2004
Evidence that inhibited prostatic epithelial bud formation in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed C57BL/6J fetal mice is not due to interruption of androgen signaling in the urogenital sinus.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 79, Issue:2

    Topics: Androgen Antagonists; Animals; Cells, Cultured; Dihydrotestosterone; Environmental Pollutants; Epith

2004
[A mouse model of hypospadias induced by flutamide].
    Zhonghua nan ke xue = National journal of andrology, 2004, Volume: 10, Issue:3

    Topics: Androgen Antagonists; Animals; Disease Models, Animal; Female; Fetus; Flutamide; Hypospadias; Male;

2004
Endocrine-disrupting activity in carbendazim-induced reproductive and developmental toxicity in rats.
    Journal of toxicology and environmental health. Part A, 2004, Oct-08, Volume: 67, Issue:19

    Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Benomyl; Benzimidazoles; Carbamates; Dos

2004
The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens.
    The Journal of endocrinology, 2004, Volume: 183, Issue:1

    Topics: Androgen Antagonists; Animals; Apoptosis; Dose-Response Relationship, Drug; Embryonic Development; F

2004
Factors regulating the timing of puberty onset in female rhesus monkeys (Macaca mulatta): role of prenatal androgens, social rank, and adolescent body weight.
    Biology of reproduction, 2005, Volume: 72, Issue:5

    Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Body Weight; Female; Flutamide; Gestational A

2005
Application of an antiandrogen during pregnancy infantilizes the male offsprings' behaviour.
    Behavioural brain research, 2005, Mar-07, Volume: 158, Issue:1

    Topics: Age Factors; Agonistic Behavior; Androgen Antagonists; Animals; Behavior, Animal; Female; Flutamide;

2005
Effects of in utero and lactational exposure to flutamide in SD rats: comparison of the effects of administration periods.
    Toxicology, 2005, Apr-01, Volume: 209, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Fl

2005
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
    The Journal of toxicological sciences, 2004, Volume: 29, Issue:5

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation

2004
Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero.
    American journal of obstetrics and gynecology, 2005, Volume: 192, Issue:3

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Diet, Protein-Restricted; Female; Flutamide; Gesta

2005
Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve.
    Journal of pediatric surgery, 2005, Volume: 40, Issue:2

    Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Calcitonin Gene-Re

2005
Androgens induce relaxation of contractile activity in pregnant human myometrium at term: a nongenomic action on L-type calcium channels.
    Biology of reproduction, 2005, Volume: 73, Issue:2

    Topics: Androgen Antagonists; Androgens; Androstenediol; Androsterone; Calcium Channels, L-Type; Dehydroepia

2005
19-Nortestosterone influences neural stem cell proliferation and neurogenesis in the rat brain.
    The European journal of neuroscience, 2005, Volume: 21, Issue:4

    Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Blotting, Western; Brain; Bromodeoxyuridine;

2005
Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 85, Issue:2

    Topics: Androgen Antagonists; Androgens; Animals; Cryptorchidism; Epididymis; Female; Flutamide; Genitalia,

2005
The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action.
    Endocrinology, 2005, Volume: 146, Issue:9

    Topics: 17-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Cholesterol Side-Chain Cleavage Enz

2005
Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:4

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Conditioning, Psychological; Estrus; F

2005
Prenatal androgen blockade accelerates pubertal development in male rhesus monkeys.
    Psychoneuroendocrinology, 2006, Volume: 31, Issue:1

    Topics: Androgen Antagonists; Animals; Female; Flutamide; Gonadotropin-Releasing Hormone; Hierarchy, Social;

2006
Evaluation of general behavior, memory, learning performance, and brain sexual differentiation in F1 offspring males of rats treated with flutamide during late gestation.
    The Journal of toxicological sciences, 2005, Volume: 30, Issue:3

    Topics: Androgen Antagonists; Animals; Avoidance Learning; Behavior, Animal; Castration; Dose-Response Relat

2005
Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: life history differences and effects of prenatal androgens.
    Developmental psychobiology, 2005, Volume: 47, Issue:4

    Topics: Agonistic Behavior; Androgen Antagonists; Animals; Discriminant Analysis; Female; Flutamide; Macaca

2005
Germ cell atypia in undescended testes hinges on the aetiology of cryptorchidism but not the abdominal location per se.
    International journal of andrology, 2006, Volume: 29, Issue:1

    Topics: Abdomen; Androgen Antagonists; Animals; Carcinoma in Situ; Cryptorchidism; Dichlorodiphenyl Dichloro

2006
[Impact of flutamide on sex differentiation in rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006, Volume: 37, Issue:2

    Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Hypospadias; Male; Pregnancy; Pren

2006
Sex differences in otoacoustic emissions measured in rhesus monkeys (Macaca mulatta).
    Hormones and behavior, 2006, Volume: 50, Issue:2

    Topics: Androgen Antagonists; Androgens; Animal Communication; Animals; Cochlea; Data Interpretation, Statis

2006
Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide.
    Endocrinology, 2006, Volume: 147, Issue:10

    Topics: Androgen Antagonists; Androgens; Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell P

2006
[The effects of flutamide on the full gene expression of early testis development of embryonic period male SD].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006, Volume: 37, Issue:4

    Topics: Androgen Antagonists; Animals; Female; Flutamide; Gene Expression Profiling; Gene Expression Regulat

2006
Role of androgens in fetal testis development and dysgenesis.
    Endocrinology, 2007, Volume: 148, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Androgen Antagonists; Animals; Body Weight; Carcinogens; Dibutyl P

2007
Cognitive performance in rhesus monkeys varies by sex and prenatal androgen exposure.
    Hormones and behavior, 2007, Volume: 51, Issue:4

    Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Discrimination Learning; Female; Flu

2007
Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 98, Issue:1

    Topics: Algorithms; Androgen Antagonists; Animals; Body Weight; Bridged Bicyclo Compounds; Endpoint Determin

2007
The critical time window for androgen-dependent development of the Wolffian duct in the rat.
    Endocrinology, 2007, Volume: 148, Issue:7

    Topics: Androgen Antagonists; Androgens; Animals; Blotting, Western; Cell Differentiation; Cell Proliferatio

2007
Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.
    Brain research, 2007, Aug-24, Volume: 1165

    Topics: Anastrozole; Androgen Antagonists; Androgens; Animals; Aromatase Inhibitors; Cell Death; Cells, Cult

2007
Activation of the androgen receptor alters the intracellular calcium response to glutamate in primary hippocampal neurons and modulates sarco/endoplasmic reticulum calcium ATPase 2 transcription.
    Neuroscience, 2007, Oct-12, Volume: 149, Issue:1

    Topics: Androgen Antagonists; Androgens; Animals; Calcium; Cells, Cultured; Dihydrotestosterone; Dose-Respon

2007
In vivo and in vitro effects of flutamide and diethylstilbestrol on fetal testicular steroidogenesis in the rat.
    Reproductive toxicology (Elmsford, N.Y.), 2008, Volume: 25, Issue:1

    Topics: Androgen Antagonists; Animals; Autocrine Communication; Diethylstilbestrol; Dose-Response Relationsh

2008
The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the rat.
    Journal of pediatric surgery, 2007, Volume: 42, Issue:12

    Topics: Abdominal Muscles; Animals; Animals, Newborn; Cryptorchidism; Disease Models, Animal; Female; Flutam

2007
Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat.
    Environmental health perspectives, 2007, Volume: 115 Suppl 1

    Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Syn

2007
Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.
    The Journal of endocrinology, 2008, Volume: 196, Issue:1

    Topics: Androgen Antagonists; Animals; Apoptosis; Cells, Cultured; Coculture Techniques; Down-Regulation; Fe

2008
Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis.
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:5

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Biomechanical Phenomena; Ce

2008
Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum.
    Developmental biology, 2008, Jun-01, Volume: 318, Issue:1

    Topics: Androgen Antagonists; Animals; Cell Differentiation; Cell Lineage; Cloaca; Endoderm; Female; Flutami

2008
Testicular hormones and intermale aggressive behaviour in the presence of a female rat.
    The Journal of endocrinology, 1984, Volume: 100, Issue:3

    Topics: Aggression; Androgen Antagonists; Animals; Castration; Estrus; Female; Flutamide; Male; Pregnancy; R

1984
Effects of an anti-androgen and 5 alpha-reductase inhibitors on estrus duration in the cycling female rat.
    Physiology & behavior, 1983, Volume: 30, Issue:4

    Topics: Anilides; Animals; Azasteroids; Castration; Dihydrotestosterone; Estradiol; Estrus; Female; Flutamid

1983
Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1983, Volume: 3, Issue:2

    Topics: Aging; Anilides; Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Muscle Development; Neur

1983
Inhibition of development of both androgen-dependent and androgen-independent pigment cells in scrotal skin dermis of the rat by antiandrogen treatment during fetal growth.
    Endocrinology, 1983, Volume: 112, Issue:1

    Topics: Androgen Antagonists; Animals; Cell Differentiation; Female; Fetus; Flutamide; Growth; Male; Melanoc

1983
Dihydrotestosterone inhibits fetal rabbit pulmonary surfactant production.
    The Journal of clinical investigation, 1982, Volume: 69, Issue:3

    Topics: Animals; Body Weight; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Flutamide; Huma

1982
Effect of anti-androgen and 5 alpha-reductase inhibitor on hormone-induced sexual behavior during pregnancy in the rat.
    Biology of reproduction, 1980, Volume: 23, Issue:4

    Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Castration; Dihydrotestosterone; Estradiol; Fema

1980
Flutamide-induced cryptorchidism in the rat is associated with altered gubernacular morphology.
    Urology, 1995, Volume: 46, Issue:4

    Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Gestational Age; Male; Pregnancy;

1995
The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen.
    Molecular and cellular endocrinology, 1994, Volume: 105, Issue:1

    Topics: Androgens; Animals; Blotting, Western; Dihydrotestosterone; Female; Flutamide; Male; Pregnancy; Rats

1994
Alterations in maternal epidermal growth factor (EGF) effect testicular descent and epididymal development.
    Urology, 1994, Volume: 43, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epidermal Growth Factor; Epididymis; Female; F

1994
Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats.
    The Journal of urology, 1994, Volume: 152, Issue:2 Pt 2

    Topics: Animals; Capsaicin; Cryptorchidism; Female; Flutamide; Male; Pregnancy; Prenatal Exposure Delayed Ef

1994
Expression of androgen receptor protein within the lumbar spinal cord during ontologic development and following antiandrogen induced cryptorchidism.
    The Journal of urology, 1994, Volume: 152, Issue:2 Pt 2

    Topics: Animals; Cell Count; Cryptorchidism; Female; Flutamide; Immunohistochemistry; Lumbosacral Region; Ma

1994
Epidermal growth factor reverses antiandrogen induced cryptorchidism and epididymal development.
    The Journal of urology, 1994, Volume: 152, Issue:2 Pt 2

    Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epidermal Growth Factor; Epididymis; Female; F

1994
Influence of the anti-androgen hydroxyflutamide on in vitro development of mouse embryos.
    Journal of reproduction and fertility, 1993, Volume: 99, Issue:2

    Topics: Androgen Antagonists; Animals; Blastomeres; Cells, Cultured; Cleavage Stage, Ovum; Dose-Response Rel

1993
Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1993, Volume: 17, Issue:6

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; Animals, Newborn; Brain Chemistry; Cytoch

1993
Aberrant hormone balance in fetal autoimmune NZB/W mice following prenatal exposure to testosterone excess or the androgen blocker flutamide.
    Biology of reproduction, 1995, Volume: 53, Issue:5

    Topics: alpha-Fetoproteins; Androgen Antagonists; Animals; Aromatase; Autoimmunity; Estradiol; Female; Fetal

1995
The abnormal development of male sex organs in the rat using a pure antiandrogen and a 5 alpha-reductase inhibitor during gestation.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1995, Volume: 45, Issue:1

    Topics: Androgen Antagonists; Animals; Enzyme Inhibitors; Female; Finasteride; Flutamide; Genitalia, Male; M

1995
Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone.
    The Journal of clinical investigation, 1996, Jun-01, Volume: 97, Issue:11

    Topics: Animals; Diethylstilbestrol; Dihydrotestosterone; Epidermal Cells; Epidermis; Female; Fetus; Flutami

1996
Developmental pattern and regulation by androgens of androgen receptor expression in the urogenital tract of the rat.
    Molecular and cellular endocrinology, 1995, Sep-22, Volume: 113, Issue:2

    Topics: Androgen Antagonists; Androgens; Animals; Dihydrotestosterone; Epididymis; Female; Flutamide; Gestat

1995
Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice.
    Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:11

    Topics: Androgen Antagonists; Androgens; Animals; Epididymis; Female; Flutamide; Genitalia, Male; Gestationa

1995
[The effect of prenatal stress on the development of hypophyseal gonadotropic function in male rats].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1996, Volume: 82, Issue:4

    Topics: Androgen Antagonists; Androstatrienes; Animals; Aromatase; Aromatase Inhibitors; Cholestenone 5 alph

1996
Scanning electron microscopy shows inhibited gubernacular development in relation to undescended testes in oestrogen-treated mice.
    International journal of andrology, 1996, Volume: 19, Issue:5

    Topics: Androgen Antagonists; Animals; Cryptorchidism; Embryo, Mammalian; Estrogens; Female; Flutamide; Male

1996
Interaction of mouse placental lactogens and androgens in regulating progesterone release in cultured mouse luteal cells.
    Endocrinology, 1997, Volume: 138, Issue:8

    Topics: Androgen Receptor Antagonists; Androgens; Androstenedione; Animals; Aromatase Inhibitors; Cattle; Ce

1997
Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal life.
    Endocrinology, 1998, Volume: 139, Issue:4

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen Antagonists; Animals; Blotting, Southern; Brain; Fem

1998
Direct actions of gonadal steroid hormones on FSH secretion and expression in the infantile female rat.
    The Journal of steroid biochemistry and molecular biology, 1998, Volume: 66, Issue:1-2

    Topics: Animals; Animals, Newborn; Cells, Cultured; Dihydrotestosterone; Estradiol; Female; Flutamide; Folli

1998
Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 2. Effects of prenatal anti-androgens.
    Journal of reproduction and fertility, 1998, Volume: 113, Issue:1

    Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androstenedione; Animals; Carnivora; Cyproterone

1998
Androgen-dependent modulation of calbindin-D28K in hypothalamic tissue during prenatal development.
    Neuroscience research, 1998, Volume: 32, Issue:1

    Topics: Anal Canal; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Blotting, Western; Brain

1998
Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE.
    Toxicological sciences : an official journal of the Society of Toxicology, 1998, Volume: 45, Issue:2

    Topics: Animals; Animals, Suckling; Brain; Dichlorodiphenyl Dichloroethylene; Female; Flutamide; Genitalia,

1998
Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats.
    Hormones and behavior, 1999, Volume: 35, Issue:1

    Topics: Age Factors; Anal Canal; Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Corticosteron

1999
Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.
    Toxicology and applied pharmacology, 1999, Apr-15, Volume: 156, Issue:2

    Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Cryptorchid

1999
Androgens modulate interleukin-6 production by gingival fibroblasts in vitro.
    Journal of periodontology, 1999, Volume: 70, Issue:6

    Topics: Androgen Antagonists; Androgens; Cells, Cultured; Culture Media, Conditioned; Dihydrotestosterone; D

1999
Modulation of testosterone-metabolizing hepatic cytochrome P-450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p'-DDE.
    Toxicology and applied pharmacology, 1999, Jul-15, Volume: 158, Issue:2

    Topics: Age Factors; Androgen Antagonists; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme S

1999
Prenatal flutamide treatment eliminates the adult male rat's dependency upon vasopressin when forming social-olfactory memories.
    Hormones and behavior, 1999, Volume: 36, Issue:2

    Topics: Androgen Antagonists; Animals; Cognition; Female; Flutamide; Male; Memory; Pregnancy; Prenatal Expos

1999
In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation.
    Toxicology and applied pharmacology, 1999, Dec-15, Volume: 161, Issue:3

    Topics: Adipose Tissue; Administration, Oral; Androgen Antagonists; Animals; Blotting, Northern; Clusterin;

1999
Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus.
    Brain research. Developmental brain research, 2000, Apr-14, Volume: 120, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Animals, Newborn; Female; Flutamide; H

2000
Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat.
    Toxicology and applied pharmacology, 2000, Sep-01, Volume: 167, Issue:2

    Topics: Androgens; Animals; Animals, Newborn; Dihydrotestosterone; Dose-Response Relationship, Drug; Female;

2000
Influence of gonadal hormones on the development of parental behavior in adult virgin prairie voles (Microtus ochrogaster).
    Behavioural brain research, 2000, Volume: 114, Issue:1-2

    Topics: Androgen Antagonists; Androstatrienes; Animals; Aromatase Inhibitors; Arvicolinae; Enzyme Inhibitors

2000
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism.
    Pediatric surgery international, 2000, Volume: 16, Issue:7

    Topics: Androgen Antagonists; Animals; Cryptorchidism; Disease Models, Animal; Female; Fertility; Flutamide;

2000
Sexual dimorphism and aromatase in the rat retina.
    Brain research. Developmental brain research, 2001, Jan-31, Volume: 126, Issue:1

    Topics: Androgen Antagonists; Animals; Aromatase; Female; Flutamide; Male; Orchiectomy; Pregnancy; Rats; Rat

2001
The effects of sialoadenectomy & flutamide on skin development.
    Clinical and experimental obstetrics & gynecology, 2000, Volume: 27, Issue:3-4

    Topics: Androgen Antagonists; Animals; Atrophy; Epidermal Growth Factor; Epidermis; Female; Flutamide; Hair

2000
The biological effect of phthalate esters on transabdominal migration of the testis in fetal rats in comparison with the antiandrogen flutamide.
    Pediatric surgery international, 2001, Volume: 17, Issue:2-3

    Topics: Animals; Cryptorchidism; Female; Flutamide; Gestational Age; Humans; Infant, Newborn; Male; Phthalic

2001
Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens.
    Hormones and behavior, 2001, Volume: 39, Issue:4

    Topics: Androgen Antagonists; Androgens; Animals; Anxiety, Separation; Female; Flutamide; Macaca mulatta; Ma

2001
Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 62, Issue:2

    Topics: Anal Canal; Androgen Antagonists; Androgens; Animals; Dose-Response Relationship, Drug; Female; Flut

2001
Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 64, Issue:2

    Topics: Androgen Antagonists; Animals; Clusterin; Dibutyl Phthalate; Female; Fetus; Flutamide; Gene Expressi

2001
Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory.
    BMC neuroscience, 2001, Volume: 2

    Topics: Androgen Antagonists; Animals; Behavior, Animal; Cues; Estrogens, Non-Steroidal; Female; Flutamide;

2001
Effect of prenatal androgen receptor antagonist or aromatase inhibitor on sexual behavior, partner preference and neuronal Fos responses to estrous female odors in the rat accessory olfactory system.
    Physiology & behavior, 2002, Volume: 75, Issue:3

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androstatrienes; Animals; Aromatase Inhibitors;

2002
Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats.
    The Journal of toxicological sciences, 2002, Volume: 27, Issue:1

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Androgen Antagonists; Animals; Animals, Newborn;

2002
Evidence for a role of androgens in the growth and maturation of ovarian follicles in rats.
    Hormone research, 1978, Volume: 9, Issue:2

    Topics: Androgens; Animals; Corpus Luteum; Cyproterone; Diestrus; Estradiol; Estrus; Female; Flutamide; Ovar

1978
Androgenic influences on feminine sexual behavior in male and female rats: defeminization blocked by prenatal antiandrogen treatment.
    Endocrinology, 1978, Volume: 103, Issue:5

    Topics: Anilides; Animals; Castration; Estradiol; Female; Flutamide; Male; Maternal-Fetal Exchange; Pregnanc

1978
Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies.
    Endocrinology, 1992, Volume: 131, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Androstenes; Animals; Azasteroids; Dose

1992
Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens.
    Endocrinology, 1992, Volume: 131, Issue:4

    Topics: Androgens; Animals; Atrophy; Cryptorchidism; Drug Combinations; Female; Flutamide; Gestational Age;

1992
Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide.
    Journal of reproduction and fertility, 1992, Volume: 96, Issue:2

    Topics: Androgen-Insensitivity Syndrome; Animals; Body Weight; Chi-Square Distribution; Cryptorchidism; Epid

1992
The effect of androgen, estrogen, and growth factors on the proliferation of cultured fibroblasts derived from human fetal and adult prostates.
    Endocrinology, 1992, Volume: 130, Issue:4

    Topics: Cell Division; Cells, Cultured; Dihydrotestosterone; Epidermal Growth Factor; Estradiol; Female; Fet

1992
Prenatal flutamide alters sexually dimorphic nuclei in the spinal cord of male rats.
    Brain research, 1992, Apr-24, Volume: 578, Issue:1-2

    Topics: Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Neurons; Pregnancy; Rats; Rats, Inbred St

1992
Effects of flutamide and finasteride on rat testicular descent.
    Endocrinology, 1991, Volume: 129, Issue:2

    Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgens; Androstenes; Animals; Azasteroids; Cr

1991
Time-specific androgen blockade with flutamide inhibits testicular descent in the rat.
    Endocrinology, 1991, Volume: 129, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Azasteroids; Cryptorchidism; Embryonic and Fetal

1991
Effects of prenatal antiandrogen treatment on masculinization and defeminization of guinea pigs.
    Physiology & behavior, 1991, Volume: 50, Issue:3

    Topics: Androgen Antagonists; Animals; Estradiol; Female; Flutamide; Guinea Pigs; In Vitro Techniques; Male;

1991
Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats.
    Behavioural brain research, 1991, Jul-01, Volume: 44, Issue:1

    Topics: Animals; Animals, Newborn; Estrus; Female; Fetus; Flutamide; Hysterectomy; Male; Pregnancy; Prenatal

1991
Hormonal manipulation of the prenatal environment alters reproductive morphology and increases longevity in autoimmune NZB/W mice.
    Biology of reproduction, 1991, Volume: 44, Issue:4

    Topics: Animals; Autoimmune Diseases; Female; Fetus; Flutamide; Hormones; Longevity; Male; Maternal-Fetal Ex

1991
On the organization of partner preference behavior in female Wistar rats.
    Physiology & behavior, 1991, Volume: 49, Issue:3

    Topics: Androgen Antagonists; Animals; Copulation; Dihydrotestosterone; Dose-Response Relationship, Drug; Es

1991
Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide.
    Biology of reproduction, 1990, Volume: 42, Issue:1

    Topics: Anilides; Animals; Decidua; Embryo Implantation; Embryo Implantation, Delayed; Female; Flutamide; Pr

1990
Hypogastric ganglion perinatal development: evidence for androgen specificity via androgen receptors.
    Brain research, 1989, Apr-17, Volume: 485, Issue:1

    Topics: Adrenergic Fibers; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Flutamide; Hypo

1989
Studies on the mechanism of action of Win 49596: a steroidal androgen receptor antagonist.
    Journal of steroid biochemistry, 1989, Volume: 33, Issue:6

    Topics: Androgen Receptor Antagonists; Animals; Female; Flutamide; Genitalia, Male; Male; Microsomes; Placen

1989
Embryonic sex steroids affect mating behavior and plasma LH in adult chickens.
    Physiology & behavior, 1989, Volume: 45, Issue:6

    Topics: Androstatrienes; Animals; Chickens; Estradiol; Female; Flutamide; Gonadal Steroid Hormones; Luteiniz

1989
Effects of an antiandrogen, flutamide, on oocyte quality and embryo development in rats superovulated with pregnant mare's serum gonadotropin.
    Biology of reproduction, 1988, Volume: 39, Issue:2

    Topics: Androgens; Anilides; Animals; Embryonic and Fetal Development; Embryonic Development; Estradiol; Fem

1988
Nipple development and pup-induced prolactin release in male rats treated prenatally with the antiandrogen flutamide.
    Psychoneuroendocrinology, 1988, Volume: 13, Issue:4

    Topics: Anilides; Animals; Breast; Estradiol; Female; Flutamide; Lactation; Male; Maternal Behavior; Nipples

1988
Perinatal androgen manipulations do not affect feminine behavioral potentials in voles.
    Physiology & behavior, 1986, Volume: 36, Issue:3

    Topics: Androgens; Androstatrienes; Animals; Animals, Newborn; Arvicolinae; Estradiol; Female; Flutamide; Ma

1986
Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes.
    Physiology & behavior, 1986, Volume: 37, Issue:1

    Topics: Androstatrienes; Anilides; Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Estradio

1986
Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan.
    Acta endocrinologica, 1985, Volume: 109, Issue:4

    Topics: Anilides; Animals; Body Weight; Busulfan; Female; Flutamide; Follicle Stimulating Hormone; Hypothala

1985
Prenatal antiandrogen feminizes behavioral but not neurochemical response to estrogen.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:3

    Topics: Androgen Antagonists; Animals; Brain Chemistry; Estradiol; Estrogens; Female; Flutamide; Male; Ovari

1985