flutamide has been researched along with Neuroblastoma in 3 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nandrolone treatment (10-10 M) caused a time-dependent and concentration-dependent downregulation of mu opioid receptor (MOPr) transcripts in SH-SY5Y human neuroblastoma cells." | 5.35 | Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells. ( Guarino, G; Spampinato, S, 2008) |
| "Nandrolone treatment (10-10 M) caused a time-dependent and concentration-dependent downregulation of mu opioid receptor (MOPr) transcripts in SH-SY5Y human neuroblastoma cells." | 1.35 | Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells. ( Guarino, G; Spampinato, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guarino, G | 1 |
| Spampinato, S | 1 |
| Darrington, RS | 1 |
| Butler, R | 1 |
| Leigh, PN | 1 |
| McPhaul, MJ | 1 |
| Gallo, JM | 1 |
| Chisu, V | 1 |
| Manca, P | 1 |
| Lepore, G | 1 |
| Gadau, S | 1 |
| Zedda, M | 1 |
| Farina, V | 1 |
3 other studies available for flutamide and Neuroblastoma
| Article | Year |
|---|---|
Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells.
Topics: Androgen Antagonists; Blotting, Western; Cell Line, Tumor; Dactinomycin; Flutamide; Gene Expression | 2008 |
Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells.
Topics: Androgen Antagonists; Animals; Blotting, Western; Cell Line; Cyproterone Acetate; Estrogen Antagonis | 2002 |
Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell line.
Topics: Androgen Antagonists; Animals; Brain; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Shape; Fl | 2006 |