Page last updated: 2024-10-27

flutamide and Local Neoplasm Recurrence

flutamide has been researched along with Local Neoplasm Recurrence in 40 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Research Excerpts

ExcerptRelevanceReference
"The vast majority of residual tumors were poorly differentiated (Gleason score ≥ 8)."2.76Residual prostate cancer in patients treated with endocrine therapy with or without radical radiotherapy: a side study of the SPCG-7 randomized trial. ( Ahlgren, G; Angelsen, A; Bergh, A; Haugen, OA; Solberg, A; Tasdemir, I; Viset, T; Widmark, A, 2011)
"Men with BR of prostate cancer after radical prostatectomy (RP) or radiation (RT) were treated with androgen deprivation therapy (ADT) comprised of leuprolide and flutamide."2.75Duration of first off-treatment interval is prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation. ( Etzioni, RD; Gulati, R; Higano, CS; Jiang, P; Nelson, PS; Russell, KJ; Tam, S; Telesca, D; Yu, EY, 2010)
"Men with localized but unfavorable-risk prostate cancer who were treated with RT and 6 months of planned combined AST appear to have an increased risk of recurrence when treated with less than as compared with 6 months of the antiandrogen."2.73Risk of prostate cancer recurrence in men treated with radiation alone or in conjunction with combined or less than combined androgen suppression therapy. ( Chen, MH; D'Amico, AV; Kantoff, PW; Loffredo, B; Renshaw, AA, 2008)
"Patients with hormone relapsed prostate cancer (HRPC) are often treated with flutamide or diethylstilboestrol."2.70Prospective randomised trial comparing diethylstilboestrol and flutamide in the treatment of hormone relapsed prostate cancer. ( Basketter, V; Burns-Cox, N; Higgins, B; Holmes, S, 2002)
"Patient data related to prostatic intraepithelial neoplasia were analyzed."2.69Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance. ( Balaji, KC; Bastar, A; Fair, WR; Rabbani, F; Tsai, H, 1999)
"Regarding local disease progression, the advantage for the use of NHT approached but did not reach statistical significance:18 of 189 patients (10%) in the NHT group and 33 of 209 patients (16%) in the RP group (P = 0."2.69Neoadjuvant hormonal therapy prior to radical prostatectomy: the European experience. ( Debruyne, FM; Witjes, WP, 2000)
"To assess the pathological staging and biochemical progression-free survival (assessed using serum prostate-specific antigen level) of patients with clinically localized prostate cancer using neoadjuvant androgen deprivation therapy (ADT) in combination with radical retropubic prostatectomy (RRP)."2.68Pathological staging and biochemical recurrence after neoadjuvant androgen deprivation therapy in combination with radical prostatectomy in clinically localized prostate cancer: results of a phase II study. ( Begg, CB; Cookson, MS; Dalbagni, G; Fair, WR; Herr, H; Reuter, VE; Russo, P; Sheinfeld, J; Sogani, PC, 1997)
"Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in men, following lung cancer."2.42Clinical strategies in the management of biochemical recurrence after radical prostatectomy. ( Culkin, DJ; Zimmerman, RA, 2003)
"124 patients with prostate cancer were diagnosed and followed at Kobe City General Hospital between 1995 and 1997."1.31Prostate-specific antigen levels and clinical response to flutamide as the second hormone therapy for hormone-refractory prostate carcinoma. ( Fujikawa, K; Fukuzawa, S; Matsui, Y; Takeuchi, H, 2000)
"To compare disease progression and survival of patients with stage D1 adenocarcinoma after treatment with either early androgen ablation alone or combined with radical prostatectomy."1.30Early endocrine therapy versus radical prostatectomy combined with early endocrine therapy for stage D1 prostate cancer. ( Lubos, W; Schmeller, N, 1997)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.00)18.7374
1990's10 (25.00)18.2507
2000's18 (45.00)29.6817
2010's10 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Verhoven, B1
Yan, Y1
Ritter, M1
Khor, LY1
Hammond, E1
Jones, C1
Amin, M1
Bahary, JP2
Zeitzer, K1
Pollack, A1
Hirano, D1
Hasegawa, R1
Satoh, K1
Mochida, J1
Yamanaka, Y1
Hirakata, H1
Yamaguchi, K1
Sugimoto, S1
Kawata, N1
Takahashi, S1
Matsumoto, K1
Hagiwara, M1
Hayakawa, N1
Tanaka, N1
Ito, Y1
Maeda, T1
Ninomiya, A1
Nagata, H1
Nakamura, S1
Locke, JA1
Dal Pra, A1
Supiot, S1
Warde, P1
Bristow, RG1
Krauss, DJ1
Hu, C1
Souhami, L1
Gore, EM1
Chafe, SM1
Leibenhaut, MH1
Narayan, S1
Torres-Roca, J1
Michalski, J1
Zeitzer, KL1
Donavanik, V1
Sandler, H1
McGowan, DG1
Jones, CU1
Shipley, WU1
D'Amico, AV3
Chen, MH2
Renshaw, AA2
Loffredo, B1
Kantoff, PW3
Suzuki, H2
Okihara, K1
Miyake, H1
Fujisawa, M1
Miyoshi, S1
Matsumoto, T1
Fujii, M1
Takihana, Y1
Usui, T1
Matsuda, T1
Ozono, S1
Kumon, H1
Ichikawa, T2
Miki, T1
Bañez, LL1
Blake, GW1
McLeod, DG1
Crawford, ED2
Moul, JW2
Loffredo, M2
Gannon, PO1
Poisson, AO1
Delvoye, N1
Lapointe, R1
Mes-Masson, AM1
Saad, F1
Yee, DS1
Lowrance, WT1
Eastham, JA1
Maschino, AC1
Cronin, AM1
Rabbani, F2
Yu, EY1
Gulati, R1
Telesca, D1
Jiang, P1
Tam, S1
Russell, KJ1
Nelson, PS1
Etzioni, RD1
Higano, CS1
Solberg, A1
Haugen, OA1
Viset, T1
Bergh, A1
Tasdemir, I1
Ahlgren, G1
Widmark, A1
Angelsen, A1
Okegawa, T1
Nutahara, K1
Higashihara, E1
Jang, JW1
Hwang, WT1
Guzzo, TJ1
Wein, AJ2
Haas, NB1
Both, S1
Vapiwala, N1
Burns-Cox, N1
Basketter, V1
Higgins, B1
Holmes, S1
Meineke, V1
Köhn, FM1
Pickl, U1
Ring, J1
Vogt, HJ1
Barqawi, AB1
Ziada, A1
Handel, L1
Kojima, S1
Akakura, K1
Shimbo, M1
Ito, H1
Zimmerman, RA1
Culkin, DJ1
Enepekides, DJ1
Spry, NA1
Kristjanson, L1
Hooton, B1
Hayden, L1
Neerhut, G1
Gurney, H1
Corica, T1
Korbel, E1
Weinstein, S1
McCaul, K1
Ryan, CJ1
Smith, A1
Lal, P1
Satagopan, J1
Reuter, V1
Scardino, P1
Gerald, W1
Scher, HI2
Halabi, S1
Vollmer, R1
McMahon, E1
Sanford, B1
Archer, L1
Vogelzang, NJ1
Small, EJ1
Cher, ML1
Shinohara, K1
Breslin, S1
Vapnek, J1
Carroll, PR1
Whittington, R1
Malkowicz, B1
Barnes, MM1
Broderick, GA1
Van Arsdalen, K1
Dougherty, MJ1
Zhang, ZF1
Nanus, D1
Kelly, WK1
Schmeller, N1
Lubos, W1
Cookson, MS1
Sogani, PC1
Russo, P1
Sheinfeld, J1
Herr, H1
Dalbagni, G1
Reuter, VE1
Begg, CB1
Fair, WR2
Corn, BW1
Valicenti, RK1
Mulholland, SG1
Hyslop, T1
Gomella, L1
Eulau, SM1
Tate, DJ1
Stamey, TA1
Bagshaw, MA1
Hancock, SL1
Balaji, KC1
Tsai, H1
Bastar, A1
Bhayani, SB1
Andriole, GL1
Fujikawa, K1
Matsui, Y1
Fukuzawa, S1
Takeuchi, H1
Debruyne, FM1
Witjes, WP1
Pilepich, MV1
Winter, K1
John, MJ1
Mesic, JB1
Sause, W1
Rubin, P1
Lawton, C1
Machtay, M1
Grignon, D1
Soloway, MS1
Pareek, K1
Sharifi, R1
Wajsman, Z1
McLeod, D1
Wood, DP1
Puras-Baez, A1
Prout, GR1
Kliman, B1
Daly, JJ1
Maclaughlin, RA1
Griffin, PP1
Haefliger, JM1
Labrie, F1
Dupont, A1
Bélanger, A1
Cusan, L1
Brochu, M1
Turina, E1
Pinault, S1
Lacourciere, Y1
Emond, J1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase III Trial of External Beam of Radiotherapy +/- Total Androgen Suppression for High Risk Clinically Organ-Confined Prostate Cancer[NCT00116220]Phase 3206 participants (Actual)Interventional1995-09-30Completed
Prospective Study of Natural Killer Cells in Patients With Metastatic Prostate Cancer: Relationship With Survival and Response Time to Castration[NCT02963155]30 participants (Anticipated)Interventional2016-11-30Active, not recruiting
PROGNOSTIC SIGNIFICANCE OF ENDORECTAL MRI IN PREDICTING OUTCOME AFTER COMBINED RADIATION AND ANDROGEN SUPPRESSION FOR PROSTATE CANCER: A PROSPECTIVE PHASE II STUDY[NCT00002889]Phase 2180 participants (Actual)Interventional1997-05-31Completed
Phase II Randomized Clinical Trial Comparing 3-D Conformal Radiation Therapy (RT) vs. Intensity Modulated Radiation Therapy in Post- Prostatectomy Prostate Cancer Patients[NCT02678520]Phase 20 participants (Actual)Interventional2015-12-31Withdrawn (stopped due to PI no longer at institution. Study terminated prior to enrolling subjects.)
Phase III Multicenter Randomized Trial of Adjuvant Androgen Deprivation in Combination With Three-dimensional Conformal Radiotherapy Doses in High and Intermediate Risk Localized Prostate Cancer.[NCT02175212]Phase 3362 participants (Actual)Interventional2005-11-30Completed
Phase III Study of Hypofractionated, Dose Escalation Radiotherapy vs. Conventional Pelvic Radiation Therapy Followed by HDR Brachy Boost for High Risk Adenocarcinoma of the Prostate (PCS-VI)[NCT02303327]Phase 3296 participants (Anticipated)Interventional2015-01-31Recruiting
A Phase II Study of Proton-Based Radiation Therapy With Elective Pelvic Nodal Irradiation, Concomitant Docetaxel, and Adjuvant Androgen Deprivation for High-Risk Prostate Adenocarcinoma[NCT01040624]77 participants (Actual)Interventional2009-12-31Completed
Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy[NCT00969111]70 participants (Anticipated)Interventional2009-08-31Recruiting
An Expanded Phase II Study of Hypofractionated Dose Intense Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT01368055]361 participants (Actual)Interventional2011-09-30Active, not recruiting
A Phase II Study of Hypofractionated Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT00693238]228 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Biochemical Disease Free Survival: Estimated Percentage of Participants With Biochemical Disease-free Survival at 5 Years

Biochemical relapse was defined as the time from inclusion in the study (randomization) until the patient meets criteria for Biochemical failure (Phoenix criteria: PSA nadir plus 2 ng/ml). (NCT02175212)
Timeframe: 5 years

Interventionpercentage of patients (Number)
Long Term Androgen Deprivation90
Short Term Androgen Deprivation81

Cause-specific Survival

Cause-specific survival included all deaths from prostate cancer or treatment complications, and deaths from unknown causes in patients with either active cancer or a previously documented relapse (NCT02175212)
Timeframe: 5 years

Interventionparticipants (Number)
Long Term Androgen Deprivation177
Short Term Androgen Deprivation173

Metastasis Free Survival: Estimated Percentage of Participants With Metastasis-free Survival at 5 Years

Metastasis free survival: defined as the time from inclusion in the study (randomization) until the appearance of distant metastases: a positive result in any of the tests performed (scintigraphy, chest radiography, thorax, abdominal and pelvic CT and MRI). (NCT02175212)
Timeframe: 5 years

Interventionpercentage of participants (Number)
Long Term Androgen Deprivation94
Short Term Androgen Deprivation83

Overall Survival: Estimated Percentage of Participants Alive at 5 Years

Overall Survival: defined as the time that elapses from the patient enters the study until the patient dies from any cause. (NCT02175212)
Timeframe: 5 years

Interventionpercentage of patients (Number)
Long Term Androgen Deprivation95
Short Term Androgen Deprivation86

Late Toxicity

"Defined as the maximal rectal, urinary and cardiovascular (CV) toxicity per patient more than 90 days after completion of RT.~Scoring scales used were the radiation morbidity scoring criteria of the European Organization for Research and Treatment of Cancer-Radiation Therapy Oncology Group (EORTC/RTOG) and the Common Terminology Criteria for Adverse Events (CTCAEs) v 3.0 for the remained toxicity.~CV events were defined according to the World Health Organization criteria" (NCT02175212)
Timeframe: 5 years

,
Interventionpercentage of patients (Number)
Grade 2 of more rectal toxicityGrade 2 of more urinary toxicityCardiovascular
Long Term Androgen Deprivation11.18.217.6
Short Term Androgen Deprivation7.67.37.2

Acute Grade 3 or Higher Treatment-related Toxicity Rate.

Number of participants that experienced acute grade 3 or higher, treatment-related toxicity based on CTCAE version 3.0 criteria. (NCT01040624)
Timeframe: 6 months after the completion of radiation therapy

Interventionparticipants (Number)
HR-A1
HR-B3

Acute Grade 3 (NCI CTC v4.0) or Higher Treatment-related Toxicity Rate.

(NCT00693238)
Timeframe: 6 months after the end of radiation therapy

InterventionParticipants (Number)
Low Risk Proton Radiation0
Intermediate Risk Proton Radiation0

Reviews

5 reviews available for flutamide and Local Neoplasm Recurrence

ArticleYear
Third-line hormonal therapy to treat prostate cancer relapse after initial and second-line hormonal therapy: report of 52 cases and literature review.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:8

    Topics: Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Antineopla

2014
Synergistic action of image-guided radiotherapy and androgen deprivation therapy.
    Nature reviews. Urology, 2015, Volume: 12, Issue:4

    Topics: Androgen Antagonists; Androstenes; Benzamides; Biomarkers; Combined Modality Therapy; Dose-Response

2015
Clinical strategies in the management of biochemical recurrence after radical prostatectomy.
    Clinical prostate cancer, 2003, Volume: 2, Issue:3

    Topics: Androgen Antagonists; Antifungal Agents; Cytochrome P-450 Enzyme System; Disease-Free Survival; Flut

2003
Hormone and antihormone withdrawal: implications for the management of androgen-independent prostate cancer.
    Urology, 1996, Volume: 47, Issue:1A Suppl

    Topics: Aminoglutethimide; Androgen Antagonists; Clinical Trials as Topic; Flutamide; Humans; Male; Neoplasm

1996
Hormonal manipulation for rising PSA after radical prostatectomy.
    Seminars in urologic oncology, 1999, Volume: 17, Issue:3

    Topics: Androgen Antagonists; Anilides; Drug Therapy, Combination; Enzyme Inhibitors; Finasteride; Flutamide

1999

Trials

19 trials available for flutamide and Local Neoplasm Recurrence

ArticleYear
Ki-67 is an independent predictor of metastasis and cause-specific mortality for prostate cancer patients treated on Radiation Therapy Oncology Group (RTOG) 94-08.
    International journal of radiation oncology, biology, physics, 2013, Jun-01, Volume: 86, Issue:2

    Topics: Aged; Analysis of Variance; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cell Proliferatio

2013
Importance of Local Control in Early-Stage Prostate Cancer: Outcomes of Patients With Positive Post-Radiation Therapy Biopsy Results Treated in RTOG 9408.
    International journal of radiation oncology, biology, physics, 2015, Jul-15, Volume: 92, Issue:4

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Biopsy; Combined Modality Therapy; Di

2015
Risk of prostate cancer recurrence in men treated with radiation alone or in conjunction with combined or less than combined androgen suppression therapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jun-20, Volume: 26, Issue:18

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Combined Chemotherapy

2008
Combined low-dose flutamide plus finasteride vs low-dose flutamide monotherapy for recurrent prostate cancer: a comparative analysis of two phase II trials with a long-term follow-up.
    BJU international, 2009, Volume: 104, Issue:3

    Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Pr

2009
Interval to testosterone recovery after hormonal therapy for prostate cancer and risk of death.
    International journal of radiation oncology, biology, physics, 2009, Sep-01, Volume: 75, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause o

2009
Long-term follow-up of 3-month neoadjuvant hormone therapy before radical prostatectomy in a randomized trial.
    BJU international, 2010, Volume: 105, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Epidemiologic Methods; Flutamide; Goserelin; H

2010
Duration of first off-treatment interval is prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jun-01, Volume: 28, Issue:16

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Androgen Antagonists; Antineoplastic Agents, Hormonal

2010
Residual prostate cancer in patients treated with endocrine therapy with or without radical radiotherapy: a side study of the SPCG-7 randomized trial.
    International journal of radiation oncology, biology, physics, 2011, May-01, Volume: 80, Issue:1

    Topics: Aged; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Biopsy; Combined Modality The

2011
Prospective randomised trial comparing diethylstilboestrol and flutamide in the treatment of hormone relapsed prostate cancer.
    International journal of urology : official journal of the Japanese Urological Association, 2002, Volume: 9, Issue:8

    Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Diethylstilbestrol; Flutamide; Humans;

2002
Combination of low-dose flutamide and finasteride for PSA-only recurrent prostate cancer after primary therapy.
    Urology, 2003, Volume: 62, Issue:5

    Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Aged; Androgen Antagonists; Antineoplastic Agents, Hor

2003
p53 protein expression status and recurrence in men treated with radiation and androgen suppression therapy for higher-risk prostate cancer: a prospective phase II Cancer and Leukemia Group B Study (CALGB 9682).
    Urology, 2008, Volume: 71, Issue:5

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Flutamide; Gonadotropin-Releasing Hormone; Humans; Male; Mi

2008
High failure rate associated with long-term follow-up of neoadjuvant androgen deprivation followed by radical prostatectomy for stage C prostatic cancer.
    British journal of urology, 1995, Volume: 75, Issue:6

    Topics: Adenocarcinoma; Aged; Combined Modality Therapy; Disease-Free Survival; Flutamide; Follow-Up Studies

1995
Pathological staging and biochemical recurrence after neoadjuvant androgen deprivation therapy in combination with radical prostatectomy in clinically localized prostate cancer: results of a phase II study.
    British journal of urology, 1997, Volume: 79, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival;

1997
Stage T3 prostate cancer: a nonrandomized comparison between definitive irradiation and induction hormonal manipulation plus prostatectomy.
    Urology, 1998, Volume: 51, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Androgen Antagonists; Antineoplastic Age

1998
Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance.
    The Journal of urology, 1999, Volume: 162, Issue:3 Pt 1

    Topics: Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up Studies; Humans; Leupr

1999
Neoadjuvant hormonal therapy prior to radical prostatectomy: the European experience.
    Molecular urology, 2000,Fall, Volume: 4, Issue:3

    Topics: Androgens; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Disease

2000
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Phase III radiation therapy oncology group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate.
    International journal of radiation oncology, biology, physics, 2001, Aug-01, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Cause of Death; Chemotherapy,

2001
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results.
    The Journal of urology, 2002, Volume: 167, Issue:1

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Flutamide; Follow-Up

2002
[Randomized study comparing zoladex versus zoladex plus flutamide in treatment of advanced cancer of the prostate].
    Helvetica chirurgica acta, 1992, Volume: 59, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Delayed-Action Preparations; Flutamide; Gosere

1992

Other Studies

16 other studies available for flutamide and Local Neoplasm Recurrence

ArticleYear
Prospective study on the relationship between clinical efficacy of secondary hormone therapy with flutamide and neuroendocrine differentiation in patients with relapsed prostate cancer after first line hormone therapy.
    Scandinavian journal of urology, 2014, Volume: 48, Issue:5

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Chromogranin A; Flutamide; Humans; Male; M

2014
Alternative nonsteroidal antiandrogen therapy for advanced prostate cancer that relapsed after initial maximum androgen blockade.
    The Journal of urology, 2008, Volume: 180, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flu

2008
Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients.
    Journal of immunological methods, 2009, Aug-31, Volume: 348, Issue:1-2

    Topics: Androgen Antagonists; Androgens; Antineoplastic Agents, Hormonal; Cyproterone; Flutamide; Humans; Ki

2009
Alternative antiandrogen therapy in patients with castration-resistant prostate cancer: a single-center experience.
    International journal of urology : official journal of the Japanese Urological Association, 2010, Volume: 17, Issue:11

    Topics: Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Chlormadin

2010
Upfront androgen deprivation therapy with salvage radiation may improve biochemical outcomes in prostate cancer patients with post-prostatectomy rising PSA.
    International journal of radiation oncology, biology, physics, 2012, Aug-01, Volume: 83, Issue:5

    Topics: Analysis of Variance; Androgen Antagonists; Anilides; Combined Modality Therapy; Disease-Free Surviv

2012
[Malignant priapism as a sign of a recurrent prostate cancer. Differential diagnosis of induratio penis plastica].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2003, Volume: 54, Issue:6

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Dia

2003
Alternative antiandrogens to treat prostate cancer relapse after initial hormone therapy.
    The Journal of urology, 2004, Volume: 171, Issue:2 Pt 1

    Topics: Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flutamide;

2004
Recent advances in the treatment of juvenile angiofibroma.
    Current opinion in otolaryngology & head and neck surgery, 2004, Volume: 12, Issue:6

    Topics: Angiofibroma; Antineoplastic Agents, Hormonal; Endoscopy; Flutamide; Humans; Nasopharyngeal Neoplasm

2004
Adverse effects to quality of life arising from treatment can recover with intermittent androgen suppression in men with prostate cancer.
    European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:8

    Topics: Aged; Androgen Antagonists; Flutamide; Humans; Leuprolide; Longitudinal Studies; Male; Middle Aged;

2006
Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: an early predictor of relapse or incomplete androgen suppression.
    Urology, 2006, Volume: 68, Issue:4

    Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Flutamide; Gene Expression

2006
Combined hormonal and radiation therapy for lymph node-positive prostate cancer.
    Urology, 1995, Volume: 46, Issue:2

    Topics: Adenocarcinoma; Aged; Combined Modality Therapy; Diethylstilbestrol; Disease-Free Survival; Flutamid

1995
Early endocrine therapy versus radical prostatectomy combined with early endocrine therapy for stage D1 prostate cancer.
    British journal of urology, 1997, Volume: 79, Issue:2

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Disease Progressio

1997
Effect of combined transient androgen deprivation and irradiation following radical prostatectomy for prostatic cancer.
    International journal of radiation oncology, biology, physics, 1998, Jul-01, Volume: 41, Issue:4

    Topics: Aged; Analysis of Variance; Androgen Antagonists; Antineoplastic Agents, Hormonal; Combined Modality

1998
Prostate-specific antigen levels and clinical response to flutamide as the second hormone therapy for hormone-refractory prostate carcinoma.
    European urology, 2000, Volume: 37, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Flutamide; Humans; Male; Middle Aged; Neoplasm Recurrence, Lo

2000
In vitro uptake of 3H testosterone and its conversion to dihydrotestosterone by prostatic carcinoma and other tissues.
    The Journal of urology, 1976, Volume: 116, Issue:5

    Topics: Aged; Culture Techniques; Diethylstilbestrol; Dihydrotestosterone; Flutamide; Humans; Lymphatic Meta

1976
Anti-hormone treatment for prostate cancer relapsing after treatment with flutamide and castration. Addition of aminoglutethimide and low dose hydrocortisone to combination therapy.
    British journal of urology, 1989, Volume: 63, Issue:6

    Topics: Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Flutam

1989