flutamide has been researched along with Liver Diseases in 14 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flutamide is an effective drug in treatment of hirsutism." | 7.75 | The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. ( Akcali, C; Balat, O; Cicek, H; Dikensoy, E; Pence, S, 2009) |
| "Flutamide is an effective drug in treatment of hirsutism." | 3.75 | The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. ( Akcali, C; Balat, O; Cicek, H; Dikensoy, E; Pence, S, 2009) |
| "Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer, causes a temporary increase in transaminase and in some cases severe liver dysfunction." | 3.73 | Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice. ( Doi, M; Goda, R; Ichimura, E; Matsuzaki, Y; Nagai, D; Nishikawa, K; Tomura, A, 2006) |
| "To prevent treatment withdrawal due to flutamide-induced liver dysfunction, we performed maximum androgen blockade (MAB) therapy by combining a luteinizing hormone-releasing hormone agonist or orchiectomy with low-dose flutamide (125 mg x 2/day) in patients with prostate cancer." | 3.71 | [Clinical efficacy of treatment with low-dose flutamide in maximum androgen blockade therapy]. ( Fujii, T; Hosomi, M; Kiyohara, H; Nakayama, J; Shimizu, K, 2001) |
| " This analysis could increase the information related to these adverse reactions mainly available from the published isolated cases." | 1.33 | Spontaneous reporting of hepatotoxicity associated with antiandrogens: data from the Spanish pharmacovigilance system. ( Hidalgo, A; Manso, G; Revuelta, P; Salgueiro, E; Thole, Z, 2006) |
| "We retrospectively reviewed 121 prostate cancer patients who received long-term antiandrogen, either flutamide (n = 56) or cyproterone acetate (n = 65), and had normal pretreatment serum alanine aminotransferase (ALT) levels." | 1.30 | Antiandrogen hepatotoxicity in patients with chronic viral hepatitis. ( Chen, J; Kao, JH; Lai, MK; Liu, CM; Pu, YS, 1999) |
| "Flutamide appears to cause hepatotoxic effects in certain patients." | 1.29 | Fatal and nonfatal hepatotoxicity associated with flutamide. ( Freiman, JP; Horton, ML; Tourtelot, JB; Wysowski, DK, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dikensoy, E | 1 |
| Balat, O | 1 |
| Pence, S | 1 |
| Akcali, C | 1 |
| Cicek, H | 1 |
| Matsuzaki, Y | 2 |
| Nishikawa, K | 2 |
| Takashima, E | 1 |
| Iguchi, K | 1 |
| Usui, S | 1 |
| Yamamoto, H | 1 |
| Hirano, K | 1 |
| Manso, G | 1 |
| Thole, Z | 1 |
| Salgueiro, E | 1 |
| Revuelta, P | 1 |
| Hidalgo, A | 1 |
| Nagai, D | 1 |
| Ichimura, E | 1 |
| Goda, R | 1 |
| Tomura, A | 1 |
| Doi, M | 1 |
| Shimizu, T | 1 |
| Yu, HP | 1 |
| Hsieh, YC | 1 |
| Choudhry, MA | 1 |
| Suzuki, T | 1 |
| Bland, KI | 1 |
| Chaudry, IH | 1 |
| Wysowski, DK | 1 |
| Freiman, JP | 1 |
| Tourtelot, JB | 1 |
| Horton, ML | 1 |
| Pu, YS | 1 |
| Liu, CM | 1 |
| Kao, JH | 1 |
| Chen, J | 1 |
| Lai, MK | 1 |
| Wada, T | 2 |
| Ueda, M | 1 |
| Abe, K | 1 |
| Kobari, T | 1 |
| Yamazaki, H | 2 |
| Nakata, J | 1 |
| Ikemoto, I | 2 |
| Ohishi, Y | 2 |
| Aizawa, Y | 2 |
| Shimizu, K | 1 |
| Kiyohara, H | 1 |
| Nakayama, J | 1 |
| Fujii, T | 1 |
| Hosomi, M | 1 |
| Kojima, M | 1 |
| Kamoi, K | 1 |
| Ukimura, O | 1 |
| Fujito, A | 1 |
| Nakao, M | 1 |
| Tanaka, S | 1 |
| Miyashita, H | 1 |
| Iwamoto, N | 1 |
| Ohe, H | 1 |
| Kitamori, T | 1 |
| Date, S | 1 |
| Kitamura, K | 1 |
| Araki, H | 1 |
| Aoki, T | 1 |
| Imada, N | 1 |
| Takada, H | 1 |
| Imaide, Y | 1 |
| Mikami, K | 1 |
| Uchida, M | 1 |
| Saitoh, M | 1 |
| Miki, T | 1 |
| Gomez, JL | 1 |
| Dupont, A | 1 |
| Cusan, L | 1 |
| Tremblay, M | 1 |
| Suburu, R | 1 |
| Lemay, M | 1 |
| Labrie, F | 1 |
| Møller, S | 1 |
| Iversen, P | 1 |
| Franzmann, MB | 1 |
1 review available for flutamide and Liver Diseases
| Article | Year |
|---|---|
[Therapeutic options for drug induced liver injury: the efficacy of UDCA based on EBM].
Topics: Androgen Antagonists; Animals; Chemical and Drug Induced Liver Injury; Evidence-Based Medicine; Flut | 2003 |
13 other studies available for flutamide and Liver Diseases
| Article | Year |
|---|---|
The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism.
Topics: Adolescent; Adult; Alanine Transaminase; Androgen Antagonists; Aspartate Aminotransferases; Chemical | 2009 |
Metabolite profiles of flutamide in serum from patients with flutamide-induced hepatic dysfunction.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Liver Diseases; | 2003 |
Spontaneous reporting of hepatotoxicity associated with antiandrogens: data from the Spanish pharmacovigilance system.
Topics: Adverse Drug Reaction Reporting Systems; Androgen Antagonists; Anilides; Chemical and Drug Induced L | 2006 |
Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice.
Topics: Alanine Transaminase; Amino Acids; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; C | 2006 |
Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway.
Topics: Abdominal Injuries; Androgen Antagonists; Animals; Chemokine CXCL1; Chemokines, CXC; Disease Models, | 2007 |
Fatal and nonfatal hepatotoxicity associated with flutamide.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antineoplastic Combined Chemothera | 1993 |
Antiandrogen hepatotoxicity in patients with chronic viral hepatitis.
Topics: Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cyproterone Acetate; Flutamide; | 1999 |
[Risk factor of liver disorders caused by flutamide--statistical analysis using multivariate logistic regression analysis].
Topics: Alanine Transaminase; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Flutamide; Human | 1999 |
[Changes in liver function induced by flutamide in patients with prostate cancer (studies in patients treated with total androgen blockage)].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Ch | 2000 |
[Clinical efficacy of treatment with low-dose flutamide in maximum androgen blockade therapy].
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Drug Administ | 2001 |
Clinical utility of ursodeoxycholic acid in preventing flutamide-induced hepatopathy in patients with prostate cancer: a preliminary study.
Topics: Aged; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Li | 2002 |
Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alkaline Phosphatase; Androgen | 1992 |
Flutamide-induced liver failure.
Topics: Aged; Anilides; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Liver; Liver Diseases; Ma | 1990 |