Page last updated: 2024-10-27

flutamide and Injuries

flutamide has been researched along with Injuries in 7 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.

Research Excerpts

ExcerptRelevanceReference
" Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release."7.70Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000)
" Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release."3.70Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000)
"Although the testosterone receptor antagonist flutamide restores the depressed immune function in males after trauma and hemorrhage, it remains unknown whether this agent has any salutary effects on adrenal function."3.70Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function. ( Ba, ZF; Bland, KI; Chaudry, IH; Cioffi, WG; Koo, DJ; Wang, P; Zhou, M, 2000)
"To determine whether treatment with an androgen receptor blocker (eg, flutamide) after trauma-hemorrhage and sepsis has any salutary effects on cell-mediated immunity and on the survival of male animals under those conditions."3.69Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997)
"Flutamide appears to be a useful adjunct for improving vascular endothelial function and regional hemodynamics after trauma-hemorrhage and resuscitation."1.31Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock. ( Ba, ZF; Bland, KI; Chaudry, IH; Koo, DJ; Ornan, DA; Wang, P, 2001)
"Thus flutamide appears to be a novel and useful adjunct for improving cardiovascular and hepatocellular functions in males following trauma and hemorrhagic shock."1.30Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. ( Bland, KI; Chaudry, IH; Cioffi, WG; Remmers, DE; Wang, P, 1997)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's5 (71.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mayr, S1
Walz, CR1
Angele, P1
Hernandez-Richter, T1
Chaudry, IH7
Loehe, F1
Jauch, KW1
Angele, MK2
Hildebrand, F1
Thobe, BM1
Hubbard, WJ1
Choudhry, MA1
Pape, HC1
Wichmann, MW1
Ayala, A1
Cioffi, WG4
Remmers, DE1
Wang, P3
Bland, KI4
Samy, TS1
Schwacha, MG1
Ba, ZF2
Koo, DJ2
Zhou, M1
Ornan, DA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Androgen-mediated Pathways in the Regulation of Insulin Sensitivity in Men[NCT01686828]Phase 1/Phase 253 participants (Actual)Interventional2013-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in Adipose Tissue Gene Expression

We examined whether differences in lipoprotein lipase expression would be evident across study treatment groups. RNA was isolated from whole adipose tissue gene expression, and complementary DNA (cDNA) was synthesized from 1.5 ug of RNA per sample. Gene expression was measured by polymerase chain reaction (PCR) using predesigned TaqMan® Gene Expression Assays. Standard curves were included on each plate, so Ct values were converted to copy numbers of the target gene. Expression values were normalized to the geometric mean of the housekeeping genes phosphoglycerate kinase and 18s. (NCT01686828)
Timeframe: 4 weeks

Interventiongene copy number per ng RNA (Mean)
Acyline + Placebo Gel + Placebo Pills7493
Acyline + Testosterone Gel (1.25g/d) + Placebo Pills8224
Acyline + Testosterone Gel (5g/d) + Placebo Pills7885
Acyline + Testosterone Gel (5g/d) + Letrozole8320

Insulin Sensitivity Quantified by Matsuda Index

Whole body insulin sensitivity as quantified by Matsuda Index at the end of the treatment period, calculated by the following equation: 10,000/square root of(FPG*FI)*(FPG+PG30*2+PG60*2+PG90*2+PG120)/8*(FPI+PI30*2+PI60*2+PI90*2+PI)/8). FPG=fasting plasma glucose level; FPI=fasting plasma insulin level; PG30,60,90, and 120=plasma glucose levels sampled at 30,60,90, and 120 minutes after oral glucose load; PI30,60,90, and 120=plasma insulin levels sampled at 30,60,90, and 120 minutes after the oral glucose load (NCT01686828)
Timeframe: 4 weeks

Interventionunits on a scale (Median)
Acyline & Placebo Gel & Placebo Pill5.0
Acyline & Testosterone Gel 1.25g/d & Placebo Pill9.4
Acyline & Testosterone Gel 5g/d & Placebo Pill7.2
Acyline & Testosterone Gel & Letrozole7.3

Changes in Body Composition

Fat mass and lean mass were measured by dual energy X-ray absorptiometry (DEXA) at baseline and at the end of the 4 week treatment period (NCT01686828)
Timeframe: 4 weeks

,,,
Interventionkg (Mean)
Change in fat massChange in lean mass
Acyline & Placebo Gel & Placebo Pill1.1-1.2
Acyline & Testosterone Gel & Letrozole0.5-0.3
Acyline & Testosterone Gel 1.25g/d & Placebo Pill0.7-1.4
Acyline & Testosterone Gel 5g/d & Placebo Pill-0.40.0

Other Studies

7 other studies available for flutamide and Injuries

ArticleYear
Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 101, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Antigen Presentation; CD11b Antigen; F

2006
Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage.
    Cytokine, 2006, Volume: 36, Issue:3-4

    Topics: Animals; CD3 Complex; Concanavalin A; Drug Synergism; Estradiol; Female; Flutamide; Interferon-gamma

2006
Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.
    Archives of surgery (Chicago, Ill. : 1960), 1997, Volume: 132, Issue:11

    Topics: Androgen Antagonists; Animals; Flutamide; Hemorrhage; Immunity, Cellular; Interleukins; Male; Mice;

1997
Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males.
    The American journal of physiology, 1997, Volume: 273, Issue:6

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Blood Pressure; Cardiac Output; Flutam

1997
Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:4

    Topics: Androgen Antagonists; Animals; DNA-Binding Proteins; Female; Flutamide; Hemorrhage; Interleukin-6; M

2000
Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:5

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgen Antagonists; Androgen Receptor Antagonists; An

2000
Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock.
    Archives of surgery (Chicago, Ill. : 1960), 2001, Volume: 136, Issue:10

    Topics: Acetylcholine; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Aorta; Dose-Response Re

2001