flutamide has been researched along with Injuries in 7 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release." | 7.70 | Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000) |
| " Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release." | 3.70 | Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000) |
| "Although the testosterone receptor antagonist flutamide restores the depressed immune function in males after trauma and hemorrhage, it remains unknown whether this agent has any salutary effects on adrenal function." | 3.70 | Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function. ( Ba, ZF; Bland, KI; Chaudry, IH; Cioffi, WG; Koo, DJ; Wang, P; Zhou, M, 2000) |
| "To determine whether treatment with an androgen receptor blocker (eg, flutamide) after trauma-hemorrhage and sepsis has any salutary effects on cell-mediated immunity and on the survival of male animals under those conditions." | 3.69 | Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997) |
| "Flutamide appears to be a useful adjunct for improving vascular endothelial function and regional hemodynamics after trauma-hemorrhage and resuscitation." | 1.31 | Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock. ( Ba, ZF; Bland, KI; Chaudry, IH; Koo, DJ; Ornan, DA; Wang, P, 2001) |
| "Thus flutamide appears to be a novel and useful adjunct for improving cardiovascular and hepatocellular functions in males following trauma and hemorrhagic shock." | 1.30 | Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. ( Bland, KI; Chaudry, IH; Cioffi, WG; Remmers, DE; Wang, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mayr, S | 1 |
| Walz, CR | 1 |
| Angele, P | 1 |
| Hernandez-Richter, T | 1 |
| Chaudry, IH | 7 |
| Loehe, F | 1 |
| Jauch, KW | 1 |
| Angele, MK | 2 |
| Hildebrand, F | 1 |
| Thobe, BM | 1 |
| Hubbard, WJ | 1 |
| Choudhry, MA | 1 |
| Pape, HC | 1 |
| Wichmann, MW | 1 |
| Ayala, A | 1 |
| Cioffi, WG | 4 |
| Remmers, DE | 1 |
| Wang, P | 3 |
| Bland, KI | 4 |
| Samy, TS | 1 |
| Schwacha, MG | 1 |
| Ba, ZF | 2 |
| Koo, DJ | 2 |
| Zhou, M | 1 |
| Ornan, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Androgen-mediated Pathways in the Regulation of Insulin Sensitivity in Men[NCT01686828] | Phase 1/Phase 2 | 53 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
We examined whether differences in lipoprotein lipase expression would be evident across study treatment groups. RNA was isolated from whole adipose tissue gene expression, and complementary DNA (cDNA) was synthesized from 1.5 ug of RNA per sample. Gene expression was measured by polymerase chain reaction (PCR) using predesigned TaqMan® Gene Expression Assays. Standard curves were included on each plate, so Ct values were converted to copy numbers of the target gene. Expression values were normalized to the geometric mean of the housekeeping genes phosphoglycerate kinase and 18s. (NCT01686828)
Timeframe: 4 weeks
| Intervention | gene copy number per ng RNA (Mean) |
|---|---|
| Acyline + Placebo Gel + Placebo Pills | 7493 |
| Acyline + Testosterone Gel (1.25g/d) + Placebo Pills | 8224 |
| Acyline + Testosterone Gel (5g/d) + Placebo Pills | 7885 |
| Acyline + Testosterone Gel (5g/d) + Letrozole | 8320 |
Whole body insulin sensitivity as quantified by Matsuda Index at the end of the treatment period, calculated by the following equation: 10,000/square root of(FPG*FI)*(FPG+PG30*2+PG60*2+PG90*2+PG120)/8*(FPI+PI30*2+PI60*2+PI90*2+PI)/8). FPG=fasting plasma glucose level; FPI=fasting plasma insulin level; PG30,60,90, and 120=plasma glucose levels sampled at 30,60,90, and 120 minutes after oral glucose load; PI30,60,90, and 120=plasma insulin levels sampled at 30,60,90, and 120 minutes after the oral glucose load (NCT01686828)
Timeframe: 4 weeks
| Intervention | units on a scale (Median) |
|---|---|
| Acyline & Placebo Gel & Placebo Pill | 5.0 |
| Acyline & Testosterone Gel 1.25g/d & Placebo Pill | 9.4 |
| Acyline & Testosterone Gel 5g/d & Placebo Pill | 7.2 |
| Acyline & Testosterone Gel & Letrozole | 7.3 |
Fat mass and lean mass were measured by dual energy X-ray absorptiometry (DEXA) at baseline and at the end of the 4 week treatment period (NCT01686828)
Timeframe: 4 weeks
| Intervention | kg (Mean) | |
|---|---|---|
| Change in fat mass | Change in lean mass | |
| Acyline & Placebo Gel & Placebo Pill | 1.1 | -1.2 |
| Acyline & Testosterone Gel & Letrozole | 0.5 | -0.3 |
| Acyline & Testosterone Gel 1.25g/d & Placebo Pill | 0.7 | -1.4 |
| Acyline & Testosterone Gel 5g/d & Placebo Pill | -0.4 | 0.0 |
7 other studies available for flutamide and Injuries
| Article | Year |
|---|---|
Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Antigen Presentation; CD11b Antigen; F | 2006 |
Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage.
Topics: Animals; CD3 Complex; Concanavalin A; Drug Synergism; Estradiol; Female; Flutamide; Interferon-gamma | 2006 |
Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.
Topics: Androgen Antagonists; Animals; Flutamide; Hemorrhage; Immunity, Cellular; Interleukins; Male; Mice; | 1997 |
Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Blood Pressure; Cardiac Output; Flutam | 1997 |
Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage.
Topics: Androgen Antagonists; Animals; DNA-Binding Proteins; Female; Flutamide; Hemorrhage; Interleukin-6; M | 2000 |
Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgen Antagonists; Androgen Receptor Antagonists; An | 2000 |
Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock.
Topics: Acetylcholine; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Aorta; Dose-Response Re | 2001 |