flutamide has been researched along with Hypertension in 9 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated whether gestational age of in utero low-protein diet played a role in the subsequent development of adult hypertension and whether it is gender dependent and examined whether flutamide (a specific, nonsteroidal competitive antagonist of the androgen receptor) reduces blood pressure in rat offspring that are exposed to in utero low-protein diet (6%)." | 3.73 | Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero. ( Gangula, PR; Reed, L; Yallampalli, C, 2005) |
| "Treatment with flutamide had no effect on blood pressure or renal AT1aR mRNA expression in ovariectomized controls." | 1.51 | Androgen Receptor Blockade Differentially Regulates Blood Pressure in Growth-Restricted Versus Ovarian Deficient Rats. ( Alexander, BT; Bamrick, DR; Coats, LE; Davis, GK; Intapad, S; Newsome, AD; Ojeda, NB, 2019) |
| "Flutamide treatment significantly attenuated the development of hypertension in female rats (systolic blood pressure: treated, 134." | 1.32 | Abolition of end-organ damage by antiandrogen treatment in female hypertensive transgenic rats. ( Andreev, D; Bader, M; Baltatu, O; Cayla, C; Iliescu, R, 2003) |
| "Flutamide treatment attenuated the development of hypertension in mouse renin transgenic rats with the tfm mutation." | 1.32 | Androgen receptor independent cardiovascular action of the antiandrogen flutamide. ( Bader, M; Baltatu, O; Campos, LA; Iliescu, R; Morano, I; Schlegel, WP, 2003) |
| "Flutamide treatment or tfm mutation produced a significant attenuation of the development of hypertension." | 1.31 | Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. ( Andreev, D; Bader, M; Baltatu, O; Cayla, C; Iliescu, R; Jordan, C, 2002) |
| "Flutamide (30 mg/kg) was administered subcutaneously daily (between 9 and 15 weeks of age)." | 1.30 | Effects of anti-androgen treatment on the catecholamine synthetic pathway in the adrenal medulla of spontaneously hypertensive rats. ( Asoh, M; Kobayashi, S; Kumai, T; Nakura, H; Tanaka, M; Tateishi, T; Watanabe, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, GK | 2 |
| Intapad, S | 2 |
| Newsome, AD | 2 |
| Coats, LE | 1 |
| Bamrick, DR | 1 |
| Ojeda, NB | 1 |
| Alexander, BT | 2 |
| Blesson, CS | 1 |
| Chinnathambi, V | 1 |
| Hankins, GD | 1 |
| Yallampalli, C | 2 |
| Sathishkumar, K | 1 |
| Dasinger, JH | 1 |
| Rudsenske, BR | 1 |
| Baltatu, O | 3 |
| Cayla, C | 2 |
| Iliescu, R | 3 |
| Andreev, D | 2 |
| Jordan, C | 1 |
| Bader, M | 3 |
| Campos, LA | 1 |
| Schlegel, WP | 1 |
| Morano, I | 1 |
| Gangula, PR | 1 |
| Reed, L | 1 |
| Kumai, T | 1 |
| Tanaka, M | 1 |
| Tateishi, T | 1 |
| Watanabe, M | 1 |
| Nakura, H | 1 |
| Asoh, M | 1 |
| Kobayashi, S | 1 |
| Caplea, A | 1 |
| Seachrist, D | 1 |
| Dunphy, G | 1 |
| Ely, D | 1 |
9 other studies available for flutamide and Hypertension
| Article | Year |
|---|---|
Androgen Receptor Blockade Differentially Regulates Blood Pressure in Growth-Restricted Versus Ovarian Deficient Rats.
Topics: Androgen Antagonists; Animals; Blood Pressure; Blood Pressure Determination; Estradiol; Female; Feta | 2019 |
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.
Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted Rats.
Topics: Animals; Animals, Newborn; Birth Weight; Blood Pressure Determination; Disease Models, Animal; Femal | 2016 |
Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Animals, Genetically Modified; Blood P | 2002 |
Abolition of end-organ damage by antiandrogen treatment in female hypertensive transgenic rats.
Topics: Albuminuria; Androgen Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; | 2003 |
Androgen receptor independent cardiovascular action of the antiandrogen flutamide.
Topics: Androgen Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Aorta, Thorac | 2003 |
Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diet, Protein-Restricted; Female; Flutamide; Gesta | 2005 |
Effects of anti-androgen treatment on the catecholamine synthetic pathway in the adrenal medulla of spontaneously hypertensive rats.
Topics: Actins; Adrenal Medulla; Androgen Antagonists; Animals; Blood Pressure; Catecholamines; Epinephrine; | 1998 |
Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade.
Topics: Analysis of Variance; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Blood Pressure; | 2001 |