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flutamide and Hirsutism

flutamide has been researched along with Hirsutism in 88 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the long-term safety and tolerability of flutamide therapy for hirsutism."9.14Long-term safety and tolerability of flutamide for the treatment of hirsutism. ( Balasch, J; Castelo-Branco, C; Gómez, O; Moyano, D, 2009)
" Twenty-nine women with hirsutism as a consequence of PCOS or idiopathic hirsutism were randomly assigned to receive 250 mg/day flutamide alone or 100 mg/day spironolactone plus a combination tablet of 2 mg CPA/35 microg EE, for 6 months."9.13Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: a randomised controlled study. ( Aral, Y; Bavbek, N; Culha, C; Demirbas, B; Güler, S; Karakurt, F; Sahin, I; Serter, R, 2008)
" All flutamide doses induced a significant decrease in hirsutism, acne, and seborrhea scores after 12 months compared with placebo without differences among dose levels."9.12Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. ( Alcañiz, J; Calaf, J; Callejo, J; Escobar-Jiménez, F; Espinós, JJ; Fortuny, A; López, E; Millet, A; Torres, E; Vidal, O, 2007)
"To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism (IH)."9.11Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study. ( Inal, MM; Taner, CE; Yildirim, Y, 2005)
"To assess the effectiveness of flutamide in the treatment of hirsutism, used as monotherapy or combined with oral contraceptives (OC)."9.11[Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women]. ( Aravena, L; Devoto, E, 2004)
"To compare the clinical, hormonal, biochemical and hemotological effects of flutamide versus flutamide plus an oral contraceptive (OC) in the treatment of hirsutism."9.10Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism. ( Başogul, O; Inal, M; Ispahi, C; Karanfil, C; Onoglu, A; Taner, C; Tinar, S, 2002)
"To compare the long-term (1 year) effects of flutamide (250 mg/d) and finasteride (5 mg/d) for the treatment of hirsutism in women."9.09A prospective, randomized trial comparing flutamide (250 mg/d) and finasteride (5 mg/d) in the treatment of hirsutism. ( Bayram, F; Güven, M; Müderris, II, 2000)
"The objective of this prospective randomized study was to evaluate and compare the hormonal and clinical effects of long-acting gonadotropin-releasing hormone (GnRH) agonist and a combination of GnRH agonist with combined oral contraceptive (COC) or flutamide in women with polycystic ovary syndrome (PCOS)."9.09Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism. ( Caruso, A; De Leo, V; Fulghesu, AM; la Marca, A; Morgante, G; Pasqui, L; Talluri, B; Torricelli, M, 2000)
"To evaluate the safety and efficacy of a low dose of flutamide (125 mg/day) in maintaining the clinical results already obtained using a higher dose (250 mg/day), in women suffering from hirsutism."9.09Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism. ( Bagnoli, A; Colombo, FM; Gualerzi, B; Mancini, F; Paradisi, R; Porcu, E; Ravaioli, B; Seracchioli, R; Venturoli, S; Vianello, F, 2001)
"To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism."9.09Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism. ( Falsetti, L; Gambera, A, 1999)
"Flutamide has been used successfully in the treatment of hirsutism."9.09Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day). ( Bayram, F; Güven, M; Müderris, II, 2000)
" Flutamide, a nonsteroidal antiandrogen, is known to be effective in reducing hirsutism in patients with ovarian hyperandrogenism."9.09Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide. ( de Zegher, F; Ibáñez, L; Marcos, MV; Potau, N, 2000)
"To compare triptorelin, cyproterone acetate (CPA), and flutamide, in combination with an oral contraceptive, in the treatment of hirsutism."9.09Prospective randomized study comparing the long-acting gonadotropin-releasing hormone agonist triptorelin, flutamide, and cyproterone acetate, used in combination with an oral contraceptive, in the treatment of hirsutism. ( Balsa, J; Escobar-Morreale, HF; Pazos, F; Sancho, JM; Varela, C, 1999)
"To investigate insulin metabolism and its modifications induced by the administration of flutamide, a specific antiandrogen compound, in women with idiopathic hirsutism (IH) and in nonobese women with polycystic ovary syndrome (PCOS)."9.09Treatment with flutamide improves hyperinsulinemia in women with idiopathic hirsutism. ( Ajossa, S; Cagnacci, A; Guerriero, S; Melis, GB; Orrù, M; Paoletti, AM, 1999)
"To compare the effectiveness of finasteride and flutamide in the treatment of hirsutism in patients with polycystic ovary syndrome (PCOS) and with idiopathic hirsutism."9.09Comparison of finasteride versus flutamide in the treatment of hirsutism. ( Bugari, G; Falsetti, L; Gambera, A; Iacobello, C; Legrenzi, L, 1999)
"To compare objectively the efficacies of spironolactone (100 mg/day), flutamide (250 mg/day), and finasteride (5 mg/day) in the treatment of hirsutism, 40 hirsute women were randomly assigned to double blind treatments with 1 of these 3 drugs or placebo for 6 months."9.09Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. ( Caputo, M; Castello, R; Misciali, C; Moghetti, P; Muggeo, M; Negri, C; Perrone, F; Tosi, F; Tosti, A, 2000)
"High doses of flutamide, which is the only antiandrogen that specifically blocks the androgen receptor, have recently been used with good clinical results in women with hirsutism."9.08Clinical efficacy and safety of low-dose flutamide alone and combined with an oral contraceptive for the treatment of idiopathic hirsutism. ( Cédrin, I; Dodin, S; Faure, N; Guy, J; Lemay, A; Méchain, C; Turcot-Lemay, L, 1995)
"To compare the effects of flutamide at 250 mg/d and 500 mg/d in the treatment of hirsutism."9.08A comparison between two doses of flutamide (250 mg/d and 500 mg/d) in the treatment of hirsutism. ( Bayram, F; Keleştimur, F; Müderris, II; Sahin, Y, 1997)
"To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism."9.08The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. ( Ayata, D; Bayram, F; Keleştimur, F; Müderris, II; Sahin, Y; Tutuş, A, 1996)
"The objective of this study was to compare the efficacy of flutamide and cyproterone acetate in the treatment of hirsutism."9.08Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial. ( Antoniou, G; Giannikos, L; Grigoriou, O; Karakitsos, P; Konidaris, S; Papadias, C, 1996)
"Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function."9.08Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. ( Armanini, D; Castello, R; Fontanarosa, MC; Magnani, CM; Moghetti, P; Muggeo, M; Negri, C; Tosi, F, 1995)
"Forty-four hirsute patients with polycystic ovary syndrome were randomly treated with finasteride (5 mg daily) or flutamide (250 mg twice daily) for 6 consecutive months."9.08Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome. ( De Fusco, D; Eleftheriou, G; Falsetti, L; Rosina, B, 1997)
"The aim of this work was to evaluate the efficacy of two new antiandrogen drugs, finasteride and flutamide, in 80 hirsute patients: 44 with Polycystic Ovary Syndrome (PCOS) and 36 with Idiopathic Hirsutism (IH)."9.08[Finasteride and flutamide in the treatment of hirsutism]. ( De Fusco, D; Falsetti, L; Rosina, B, 1997)
"Twenty-two polycystic ovarian disease (PCOD) patients with hirsutism were treated with flutamide (250 mg twice/d) in association with ethinyl-E2 (0."9.07Treatment of hirsutism with flutamide and a low-dosage oral contraceptive in polycystic ovarian disease patients. ( Aglianò, A; Cianci, A; Ciotta, L; Marletta, E; Palumbo, G; Pisana, L, 1994)
"In this study the efficacy of flutamide, an antiandrogen which does not have a steroid structure, or progestational and estrogenic activities, on hirsutism and hormone levels in polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) was investigated."9.07The use of antiandrogen flutamide in the treatment of hirsutism. ( Başkal, N; Cesur, V; Erdoğan, G; Kamel, N; Uysal, AR, 1994)
"To compare the clinical efficacy and safety of the pure antiandrogen flutamide and the steroidal derivative spironolactone in the treatment of hirsutism in women."9.07Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. ( Cusan, L; Dupont, A; Gomez, JL; Labrie, F; Tremblay, RR, 1994)
"To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism."9.07Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. ( Demirçay, Z; Durmuşoğlu, F; Erenus, M; Gürbüz, O; Pekin, S, 1994)
"Flutamide is an effective drug in treatment of hirsutism."7.75The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. ( Akcali, C; Balat, O; Cicek, H; Dikensoy, E; Pence, S, 2009)
"To investigate the clinical efficacy and safety of the finasteride (5 mg/day) plus flutamide (125 mg/day) combination therapy in unselected women with hirsutism, 44 women were involved in the study."7.75A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism. ( Karaca, Z; Kelestimur, F; Ozel, D; Tanriverdi, F; Unluhizarci, K, 2009)
"We describe the case of a 26-year-old girl with amenorrhea and severe hirsutism who was treated with flutamide 250 mg/day and developed liver toxicity during therapy."7.75Hepatotoxicity during low-dose flutamide treatment for hirsutism. ( Castelo-Branco, C; Del Pino, M, 2009)
"The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception."7.74[Low-dose flutamide in the treatment of hyperandrogenism in adolescents]. ( Borrielli, I; Dinatale, A; Dugo, C; Dugo, N; Fattori, A; Mastroeni, MT; Pizzo, A, 2008)
"The aim of our study was to evaluate the clinical efficacy of flutamide (Flu), when used alone, on the course of hirsutism and to assess its effect on hormonal secretion."7.69The use of flutamide in the management of hirsutism. ( Badaracco, B; Bernasconi, D; Del Monte, P; Marugo, M; Meozzi, M; Primarolo, P; Zino, V, 1994)
"Flutamide, which interacts only with the androgen receptor, is effective for hirsutism, acne and seborrhoea, and does not disturb menstrual cyclicity or ovulation."7.68The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism. ( Couzinet, B; Pholsena, M; Schaison, G; Young, J, 1993)
"The effectiveness of the antiandrogen flutamide in combination with an oral contraceptive was studied in 20 patients with moderate to severe hirsutism."7.68Treatment of hirsutism with the pure antiandrogen flutamide. ( Bélanger, A; Cusan, L; Dupont, A; Labrie, F; Manhes, G; Tremblay, RR, 1990)
"To explore the clinical usefulness of the antiandrogen flutamide in the treatment modality for hirsutism in women."7.68Treatment of hirsutism in women with flutamide. ( Kirschner, MA; Luthold, WW; Marcondes, JA; Minnani, SL; Samojlik, E; Wajchenberg, BL, 1992)
"Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor in basal conditions and after 90, 180, 270, and 360 days of treatment."6.69A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism. ( Bagnoli, A; Colombo, FM; Flamigni, C; Macrelli, S; Marescalchi, O; Paradisi, R; Ravaioli, B; Venturoli, S, 1999)
"Hyperandrogenism is a condition affecting 5-10% of adolescents."5.48Very low dose of flutamide in the treatment of hyperandrogenism. ( Canu, E; Fulghesu, AM; Melis, F; Melis, GB; Murru, G, 2018)
"Hirsutism was defined by modified Ferriman-Gallwey score (FGS)."5.32Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination. ( Bahceci, M; Bahceci, S; Bilge, M; Tuzcu, A; Tuzcu, S, 2004)
"Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS)."5.29Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. ( Angelini, F; Barletta, D; Gargani, M; Genazzani, AD; Genazzani, AR; Lippi, F; Luisi, M; Monzani, F; Pucci, E, 1995)
"To evaluate the long-term safety and tolerability of flutamide therapy for hirsutism."5.14Long-term safety and tolerability of flutamide for the treatment of hirsutism. ( Balasch, J; Castelo-Branco, C; Gómez, O; Moyano, D, 2009)
" Twenty-nine women with hirsutism as a consequence of PCOS or idiopathic hirsutism were randomly assigned to receive 250 mg/day flutamide alone or 100 mg/day spironolactone plus a combination tablet of 2 mg CPA/35 microg EE, for 6 months."5.13Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: a randomised controlled study. ( Aral, Y; Bavbek, N; Culha, C; Demirbas, B; Güler, S; Karakurt, F; Sahin, I; Serter, R, 2008)
" All flutamide doses induced a significant decrease in hirsutism, acne, and seborrhea scores after 12 months compared with placebo without differences among dose levels."5.12Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. ( Alcañiz, J; Calaf, J; Callejo, J; Escobar-Jiménez, F; Espinós, JJ; Fortuny, A; López, E; Millet, A; Torres, E; Vidal, O, 2007)
"To assess the effectiveness of flutamide in the treatment of hirsutism, used as monotherapy or combined with oral contraceptives (OC)."5.11[Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women]. ( Aravena, L; Devoto, E, 2004)
"To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism (IH)."5.11Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study. ( Inal, MM; Taner, CE; Yildirim, Y, 2005)
"To compare the clinical, hormonal, biochemical and hemotological effects of flutamide versus flutamide plus an oral contraceptive (OC) in the treatment of hirsutism."5.10Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism. ( Başogul, O; Inal, M; Ispahi, C; Karanfil, C; Onoglu, A; Taner, C; Tinar, S, 2002)
"To investigate insulin metabolism and its modifications induced by the administration of flutamide, a specific antiandrogen compound, in women with idiopathic hirsutism (IH) and in nonobese women with polycystic ovary syndrome (PCOS)."5.09Treatment with flutamide improves hyperinsulinemia in women with idiopathic hirsutism. ( Ajossa, S; Cagnacci, A; Guerriero, S; Melis, GB; Orrù, M; Paoletti, AM, 1999)
"Eighty-one hirsute women referred to a tertiary hirsutism clinic were assigned to one of three regimens: spironolactone 100 mg/day with an oral contraceptive, cyproterone acetate 50 mg/day on days 1 to 10 with an oral contraceptive, or flutamide 250 mg twice a day."5.09Recurrence rate of hirsutism after 3 different antiandrogen therapies. ( Durmuşoğlu, F; Erenus, M; Gürbüz, O; Yücelten, D, 1999)
"To compare the effectiveness of finasteride and flutamide in the treatment of hirsutism in patients with polycystic ovary syndrome (PCOS) and with idiopathic hirsutism."5.09Comparison of finasteride versus flutamide in the treatment of hirsutism. ( Bugari, G; Falsetti, L; Gambera, A; Iacobello, C; Legrenzi, L, 1999)
"To compare triptorelin, cyproterone acetate (CPA), and flutamide, in combination with an oral contraceptive, in the treatment of hirsutism."5.09Prospective randomized study comparing the long-acting gonadotropin-releasing hormone agonist triptorelin, flutamide, and cyproterone acetate, used in combination with an oral contraceptive, in the treatment of hirsutism. ( Balsa, J; Escobar-Morreale, HF; Pazos, F; Sancho, JM; Varela, C, 1999)
"To compare objectively the efficacies of spironolactone (100 mg/day), flutamide (250 mg/day), and finasteride (5 mg/day) in the treatment of hirsutism, 40 hirsute women were randomly assigned to double blind treatments with 1 of these 3 drugs or placebo for 6 months."5.09Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. ( Caputo, M; Castello, R; Misciali, C; Moghetti, P; Muggeo, M; Negri, C; Perrone, F; Tosi, F; Tosti, A, 2000)
"To compare the long-term (1 year) effects of flutamide (250 mg/d) and finasteride (5 mg/d) for the treatment of hirsutism in women."5.09A prospective, randomized trial comparing flutamide (250 mg/d) and finasteride (5 mg/d) in the treatment of hirsutism. ( Bayram, F; Güven, M; Müderris, II, 2000)
" Flutamide, a nonsteroidal antiandrogen, is known to be effective in reducing hirsutism in patients with ovarian hyperandrogenism."5.09Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide. ( de Zegher, F; Ibáñez, L; Marcos, MV; Potau, N, 2000)
"The objective of this prospective randomized study was to evaluate and compare the hormonal and clinical effects of long-acting gonadotropin-releasing hormone (GnRH) agonist and a combination of GnRH agonist with combined oral contraceptive (COC) or flutamide in women with polycystic ovary syndrome (PCOS)."5.09Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism. ( Caruso, A; De Leo, V; Fulghesu, AM; la Marca, A; Morgante, G; Pasqui, L; Talluri, B; Torricelli, M, 2000)
"Finasteride, CPA, and flutamide are equally effective in decreasing hirsutism, despite different mechanisms of action."5.09Treatment of hirsutism: comparisons between different antiandrogens with central and peripheral effects. ( Bersi, C; Fruzzetti, F; Genazzani, AR; Parrini, D; Ricci, C, 1999)
"To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism."5.09Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism. ( Falsetti, L; Gambera, A, 1999)
"The aim of this work was to evaluate the efficacy of two new antiandrogen drugs, finasteride and flutamide, in 80 hirsute patients: 44 with Polycystic Ovary Syndrome (PCOS) and 36 with Idiopathic Hirsutism (IH)."5.08[Finasteride and flutamide in the treatment of hirsutism]. ( De Fusco, D; Falsetti, L; Rosina, B, 1997)
"Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function."5.08Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. ( Armanini, D; Castello, R; Fontanarosa, MC; Magnani, CM; Moghetti, P; Muggeo, M; Negri, C; Tosi, F, 1995)
"Forty-four hirsute patients with polycystic ovary syndrome were randomly treated with finasteride (5 mg daily) or flutamide (250 mg twice daily) for 6 consecutive months."5.08Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome. ( De Fusco, D; Eleftheriou, G; Falsetti, L; Rosina, B, 1997)
"High doses of flutamide, which is the only antiandrogen that specifically blocks the androgen receptor, have recently been used with good clinical results in women with hirsutism."5.08Clinical efficacy and safety of low-dose flutamide alone and combined with an oral contraceptive for the treatment of idiopathic hirsutism. ( Cédrin, I; Dodin, S; Faure, N; Guy, J; Lemay, A; Méchain, C; Turcot-Lemay, L, 1995)
"To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism."5.08The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. ( Ayata, D; Bayram, F; Keleştimur, F; Müderris, II; Sahin, Y; Tutuş, A, 1996)
"To compare the clinical efficacy and safety of the pure antiandrogen flutamide and the steroidal derivative spironolactone in the treatment of hirsutism in women."5.07Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. ( Cusan, L; Dupont, A; Gomez, JL; Labrie, F; Tremblay, RR, 1994)
"To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism."5.07Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. ( Demirçay, Z; Durmuşoğlu, F; Erenus, M; Gürbüz, O; Pekin, S, 1994)
"Twenty-two polycystic ovarian disease (PCOD) patients with hirsutism were treated with flutamide (250 mg twice/d) in association with ethinyl-E2 (0."5.07Treatment of hirsutism with flutamide and a low-dosage oral contraceptive in polycystic ovarian disease patients. ( Aglianò, A; Cianci, A; Ciotta, L; Marletta, E; Palumbo, G; Pisana, L, 1994)
"Hirsutism was assessed before and after 3 months of treatment with flutamide 500 mg/d."5.07Clinical and endocrine effects of flutamide in hyperandrogenic women. ( De Lorenzo, D; Fioretti, P; Fruzzetti, F; Ricci, C, 1993)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: finasteride, flutamide, metformin, spironolactone, cyproterone acetate-ethinylestradiol (co-cyprindiol), interventions to achieve weight loss, ketoconazole, and mechanical hair removal."4.85PCOS. ( Cahill, D, 2009)
" A significant reduction in hirsutism was found for flutamide, spironolactone, cyproterone acetate combined with an oral contraceptive, thiazolidinediones, oral contraceptive pills (OCPs), finasteride and metformin but not for placebo."4.84A systematic review of commonly used medical treatments for hirsutism in women. ( Conway, GS; Koulouri, O, 2008)
"Patients under flutamide therapy showed significant improvements in hirsutism scores after 6 months of treatment with a maximum effect at 12 months that was maintained during all the therapy time."3.83Long-term satisfaction and tolerability with low-dose flutamide: a 20-year surveillance study on 120 hyperandrogenic women. ( Alvarez-Olivares, L; Balasch, J; Castelo-Branco, C; Hernández-Angeles, C, 2016)
"Flutamide is an effective drug in treatment of hirsutism."3.75The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. ( Akcali, C; Balat, O; Cicek, H; Dikensoy, E; Pence, S, 2009)
"We describe the case of a 26-year-old girl with amenorrhea and severe hirsutism who was treated with flutamide 250 mg/day and developed liver toxicity during therapy."3.75Hepatotoxicity during low-dose flutamide treatment for hirsutism. ( Castelo-Branco, C; Del Pino, M, 2009)
"The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception."3.74[Low-dose flutamide in the treatment of hyperandrogenism in adolescents]. ( Borrielli, I; Dinatale, A; Dugo, C; Dugo, N; Fattori, A; Mastroeni, MT; Pizzo, A, 2008)
" In 8 male patients, mean age 75 years (range 65-83), flutamide was indicated for palliative therapy of disseminated prostatic carcinoma, and in one young female (14 years) was given for the treatment of facial hirsutism."3.71Flutamide-induced hepatotoxicity: report of a case series. ( Alcántara, R; Andrade, RJ; Camargo, R; Fernández, MC; Ferrer, T; Fraga, E; García Cortés, M; García-Ruiz, E; Lucena, MI; Martín-Vivaldi, R; Montero, JL; Peláez, G; Pizarro, MA; Romero-Gómez, M; Rosemary-Gómez, M; Sánchez Martínez, H; Suárez, F, 2001)
"The aim of our study was to evaluate the clinical efficacy of flutamide (Flu), when used alone, on the course of hirsutism and to assess its effect on hormonal secretion."3.69The use of flutamide in the management of hirsutism. ( Badaracco, B; Bernasconi, D; Del Monte, P; Marugo, M; Meozzi, M; Primarolo, P; Zino, V, 1994)
"Flutamide, which interacts only with the androgen receptor, is effective for hirsutism, acne and seborrhoea, and does not disturb menstrual cyclicity or ovulation."3.68The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism. ( Couzinet, B; Pholsena, M; Schaison, G; Young, J, 1993)
"To explore the clinical usefulness of the antiandrogen flutamide in the treatment modality for hirsutism in women."3.68Treatment of hirsutism in women with flutamide. ( Kirschner, MA; Luthold, WW; Marcondes, JA; Minnani, SL; Samojlik, E; Wajchenberg, BL, 1992)
"We studied the effect of flutamide, a peripheral androgenic blocking agent, 500 mg daily for 28 days in 7 non ovulating patients with hirsutism."3.68[The effect of a peripheral androgenic blockade on plasma lipoproteins in hirsutism patients]. ( Acosta, AM; Arteaga, A; Arteaga, E; Correa, R; Fernández, C; López, X, 1990)
"Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor in basal conditions and after 90, 180, 270, and 360 days of treatment."2.69A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism. ( Bagnoli, A; Colombo, FM; Flamigni, C; Macrelli, S; Marescalchi, O; Paradisi, R; Ravaioli, B; Venturoli, S, 1999)
"Flutamide treatment determined a clinical, marked improvement of androgen hypersensitivity (Ferriman-Gallwey score: before 22."2.68Androgen-receptor blockade does not impair bone mineral density in adolescent females. ( Baroncelli, GI; Battini, R; Bertelloni, S; Costa, S; Saggese, G; Sorrentino, MC, 1997)
"Flutamide was more effective than placebo in two studies (MD -7·60, 95% CI: -10·53 to -4·67 and MD -7·20, 95% CI: -10·15 to -4·25), as was spironolactone (MD -7·69, 95% CI: -10·12 to -5·26)."2.53Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments. ( Fedorowicz, Z; van Zuuren, EJ, 2016)
"Although hirsutism and androgenetic alopecia are cosmetic problems, they can be psychologically devastating for women."2.40Antiandrogen treatment of polycystic ovary syndrome. ( Rittmaster, RS, 1999)
"Hyperandrogenism is a condition affecting 5-10% of adolescents."1.48Very low dose of flutamide in the treatment of hyperandrogenism. ( Canu, E; Fulghesu, AM; Melis, F; Melis, GB; Murru, G, 2018)
"Polycystic ovary syndrome is the underlying cause in the vast majority of patients with hirsutism; however, it should be kept in mind that it can only be diagnosed after exclusion of some other diseases such as non-classical congenital adrenal hyperplasia, Cushing's syndrome, hyperprolactinemia and acromegaly."1.39Hirsutism - from diagnosis to use of antiandrogens. ( Karaca, Z; Kelestimur, F; Unluhizarci, K, 2013)
"Hirsutism was defined by modified Ferriman-Gallwey score (FGS)."1.32Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination. ( Bahceci, M; Bahceci, S; Bilge, M; Tuzcu, A; Tuzcu, S, 2004)
"Hirsutism is the manifestation of hyperandrogenemia in PCOS."1.32The treatment of polycystic ovary syndrome. ( Ajossa, S; Guerriero, S; Melis, GB; Orrù, M; Paoletti, AM, 2004)
"Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS)."1.29Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. ( Angelini, F; Barletta, D; Gargani, M; Genazzani, AD; Genazzani, AR; Lippi, F; Luisi, M; Monzani, F; Pucci, E, 1995)
"Flutamide is a potent hepatotoxin in certain patients."1.29Flutamide hepatotoxicity. ( Fourcroy, JL; Wysowski, DK, 1996)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.14)18.7374
1990's44 (50.00)18.2507
2000's29 (32.95)29.6817
2010's13 (14.77)24.3611
2020's1 (1.14)2.80

Authors

AuthorsStudies
Zolton, JR1
Fulghesu, AM2
Melis, F1
Murru, G1
Canu, E1
Melis, GB3
Azarchi, S1
Bienenfeld, A1
Lo Sicco, K1
Marchbein, S1
Shapiro, J1
Nagler, AR1
Boztosun, A1
Açmaz, G1
Ozturk, A1
Müderris, II6
Unluhizarci, K2
Karaca, Z2
Kelestimur, F5
Ibáñez, L6
Ong, KK1
López-Bermejo, A1
Dunger, DB2
de Zegher, F6
Buzney, E1
Sheu, J1
Buzney, C1
Reynolds, RV1
van Zuuren, EJ2
Fedorowicz, Z2
Carter, B1
Pandis, N1
Díaz, M1
Gallego-Escuredo, JM1
Villarroya, F1
Castelo-Branco, C3
Hernández-Angeles, C1
Alvarez-Olivares, L1
Balasch, J2
Dikensoy, E1
Balat, O1
Pence, S1
Akcali, C1
Cicek, H1
Pizzo, A1
Borrielli, I1
Mastroeni, MT1
Fattori, A1
Dugo, C1
Dugo, N1
Dinatale, A1
Ozel, D1
Tanriverdi, F1
Cahill, D1
Del Pino, M1
Bachelot, A1
Chabbert-Buffet, N1
Salenave, S1
Kerlan, V1
Galand-Portier, MB1
Paradisi, R3
Venturoli, S3
Taner, C1
Inal, M1
Başogul, O1
Onoglu, A1
Karanfil, C1
Tinar, S1
Ispahi, C1
Ajossa, S2
Guerriero, S2
Paoletti, AM2
Orrù, M2
Sahin, Y3
Bahceci, M1
Bilge, M1
Tuzcu, A1
Tuzcu, S1
Bahceci, S1
Devoto, E1
Aravena, L1
Al-Inany, H1
Inal, MM1
Yildirim, Y1
Taner, CE1
Calaf, J1
López, E1
Millet, A1
Alcañiz, J1
Fortuny, A1
Vidal, O1
Callejo, J1
Escobar-Jiménez, F1
Torres, E1
Espinós, JJ1
Koulouri, O1
Conway, GS1
Moyano, D1
Gómez, O1
Karakurt, F1
Sahin, I1
Güler, S1
Demirbas, B1
Culha, C1
Serter, R1
Aral, Y1
Bavbek, N1
Wysowski, DK2
Fourcroy, JL2
Moghetti, P4
Castello, R4
Negri, C4
Tosi, F4
Magnani, CM1
Fontanarosa, MC1
Armanini, D1
Muggeo, M4
Presl, J1
Howe, RS1
Chow, RP1
Stevens, CL1
Erenus, M3
Motta, T2
Maggi, G2
D'Alberton, A2
Cesur, V1
Kamel, N1
Uysal, AR1
Erdoğan, G1
Başkal, N1
Ciotta, L1
Cianci, A1
Marletta, E1
Pisana, L1
Aglianò, A1
Palumbo, G1
Marugo, M1
Bernasconi, D1
Meozzi, M1
Del Monte, P1
Zino, V1
Primarolo, P1
Badaracco, B1
Wallace, C1
Lalor, EA1
Chik, CL1
Gürbüz, O2
Durmuşoğlu, F2
Demirçay, Z1
Pekin, S1
Koning, RP1
Fruzzetti, F2
De Lorenzo, D1
Ricci, C2
Fioretti, P1
Cusan, L2
Dupont, A2
Gomez, JL1
Tremblay, RR2
Labrie, F2
Couzinet, B1
Pholsena, M1
Young, J1
Schaison, G1
Grimaldi, F1
Proto, G1
Bertolissi, F1
Pucci, E1
Genazzani, AD1
Monzani, F1
Lippi, F1
Angelini, F1
Gargani, M1
Barletta, D1
Luisi, M1
Genazzani, AR2
Dodin, S1
Faure, N1
Cédrin, I1
Méchain, C1
Turcot-Lemay, L1
Guy, J1
Lemay, A1
Bayram, F5
Tutuş, A1
Ayata, D1
Grigoriou, O1
Papadias, C1
Konidaris, S1
Antoniou, G1
Karakitsos, P1
Giannikos, L1
Zemtsov, A1
Wilson, L1
Bertelloni, S1
Baroncelli, GI1
Sorrentino, MC1
Costa, S1
Battini, R1
Saggese, G1
Falsetti, L4
De Fusco, D2
Eleftheriou, G1
Rosina, B2
Young, R1
Sinclair, R1
Pazos, F1
Escobar-Morreale, HF1
Balsa, J1
Sancho, JM1
Varela, C1
Bersi, C1
Parrini, D1
Zamberlan, N1
Rossini, M1
Gatti, D1
Adami, S1
Marescalchi, O1
Colombo, FM2
Macrelli, S1
Ravaioli, B2
Bagnoli, A2
Flamigni, C1
Rittmaster, RS1
Yücelten, D1
Gambera, A2
Andrade, RJ2
Lucena, MI2
Fernández, MC2
Suárez, F2
Montero, JL2
Fraga, E2
Hidalgo, F1
Cagnacci, A1
Legrenzi, L1
Iacobello, C1
Bugari, G1
Dorizzi, R1
Fortunato, A1
Spiazzi, GG1
Tosti, A1
Misciali, C1
Perrone, F1
Caputo, M1
Güven, M2
Román Llorente, FJ1
Alvarez Navascués, C1
Suárez González, A1
González Bernal, AC1
Potau, N1
Marcos, MV1
De Leo, V1
la Marca, A1
Morgante, G1
Pasqui, L1
Talluri, B1
Torricelli, M1
Caruso, A1
Ruiz-Rebollo, M1
Atienza-Sánchez, R1
López-García, E1
García Cortés, M1
Sánchez Martínez, H1
Ferrer, T1
Martín-Vivaldi, R1
Peláez, G1
Romero-Gómez, M1
Camargo, R1
Alcántara, R1
Pizarro, MA1
García-Ruiz, E1
Rosemary-Gómez, M1
Lószió, FA1
Tóth, S1
Kocsis, J1
Szécsi, M1
Vianello, F1
Mancini, F1
Gualerzi, B1
Porcu, E1
Seracchioli, R1
Neri, RO1
Marcondes, JA1
Minnani, SL1
Luthold, WW1
Wajchenberg, BL1
Samojlik, E1
Kirschner, MA1
Perra, M1
Azzolari, E1
Casazza, S1
Sciarra, F1
Toscano, V1
Concolino, G1
Di Silverio, F1
Correa, R1
Arteaga, E1
López, X1
Arteaga, A1
Fernández, C1
Acosta, AM1
Bélanger, A1
Manhes, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gender Affirmative Treatment of Hypertrichosis With Intense Pulsed Light - Effect on Hair Reduction and Quality of Life[NCT05775328]39 participants (Anticipated)Observational2023-12-01Not yet recruiting
Clinical Metabolic and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome: A Phase 4 Randomized, Double- Blind and Placebo Control Trial[NCT00679679]Phase 430 participants (Actual)Interventional2003-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for flutamide and Hirsutism

ArticleYear
Androgens in women: Hormone-modulating therapies for skin disease.
    Journal of the American Academy of Dermatology, 2019, Volume: 80, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Alopecia; Androgen Ant

2019
Polycystic ovary syndrome: a review for dermatologists: Part II. Treatment.
    Journal of the American Academy of Dermatology, 2014, Volume: 71, Issue:5

    Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Alopecia; Androgen Antagonists; Contraceptives, Oral, C

2014
Interventions for hirsutism (excluding laser and photoepilation therapy alone).
    The Cochrane database of systematic reviews, 2015, Apr-28, Issue:4

    Topics: 5-alpha Reductase Inhibitors; Adult; Androgen Antagonists; Body Mass Index; Contraceptive Agents, Fe

2015
Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments.
    The British journal of dermatology, 2016, Volume: 175, Issue:1

    Topics: 5-alpha Reductase Inhibitors; Adolescent; Androgen Antagonists; Body Mass Index; Contraceptives, Ora

2016
PCOS.
    BMJ clinical evidence, 2009, Jan-15, Volume: 2009

    Topics: Diabetes Mellitus, Type 2; Flutamide; Hair Removal; Hirsutism; Humans; Metformin; Polycystic Ovary S

2009
Anti-androgen treatments.
    Annales d'endocrinologie, 2010, Volume: 71, Issue:1

    Topics: Androgen Antagonists; Cyproterone Acetate; Estrogens; Female; Finasteride; Flutamide; Gonadotropin-R

2010
Medical treatment regimens of hirsutism.
    Reproductive biomedicine online, 2004, Volume: 8, Issue:5

    Topics: Androgen Antagonists; Cyproterone Acetate; Drug Combinations; Enzyme Inhibitors; Ethinyl Estradiol;

2004
Polycystic ovary syndrome.
    Clinical evidence, 2004, Issue:12

    Topics: Androgen Antagonists; Cyproterone Acetate; Drug Therapy, Combination; Ethinyl Estradiol; Female; Fin

2004
A systematic review of commonly used medical treatments for hirsutism in women.
    Clinical endocrinology, 2008, Volume: 68, Issue:5

    Topics: Androgen Antagonists; Contraceptives, Oral, Hormonal; Cyproterone Acetate; Drug Therapy, Combination

2008
Hirsutes. II: Treatment.
    The Australasian journal of dermatology, 1998, Volume: 39, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgen Receptor Antagonists; Contraceptives, O

1998
Antiandrogen treatment of polycystic ovary syndrome.
    Endocrinology and metabolism clinics of North America, 1999, Volume: 28, Issue:2

    Topics: Alopecia; Androgen Antagonists; Androgens; Cyproterone Acetate; Female; Finasteride; Flutamide; Hirs

1999
Antiandrogens.
    Advances in sex hormone research, 1976, Volume: 2

    Topics: Acne Vulgaris; Androgen Antagonists; Animals; Biological Assay; Comb and Wattles; Cyproterone; Femal

1976

Trials

38 trials available for flutamide and Hirsutism

ArticleYear
Effects of ethinylestradiol-cyproterone acetate vs. pioglitazone-flutamide-metformin on plasma FGF21 levels in adolescent girls with androgen excess.
    Diabetes & metabolism, 2016, Volume: 42, Issue:3

    Topics: Adolescent; Cyproterone Acetate; Drug Combinations; Ethinyl Estradiol; Female; Fibroblast Growth Fac

2016
Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism.
    Gynecologic and obstetric investigation, 2002, Volume: 54, Issue:2

    Topics: Administration, Oral; Adult; Androgen Antagonists; Contraceptives, Oral; Cyproterone Acetate; Dehydr

2002
[Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women].
    Revista medica de Chile, 2004, Volume: 132, Issue:7

    Topics: Adolescent; Adult; Androgen Antagonists; Androgens; Biomarkers; Cohort Studies; Contraceptives, Oral

2004
Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study.
    Fertility and sterility, 2005, Volume: 84, Issue:6

    Topics: Adult; Androgen Antagonists; Cyproterone Acetate; Diuretics; Drug Combinations; Drug Therapy, Combin

2005
Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:9

    Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatitis,

2007
Long-term safety and tolerability of flutamide for the treatment of hirsutism.
    Fertility and sterility, 2009, Volume: 91, Issue:4

    Topics: Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Desogestrel; Ethinyl Estradiol; Female;

2009
Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: a randomised controlled study.
    Advances in therapy, 2008, Volume: 25, Issue:4

    Topics: Adult; Androgen Antagonists; Cyproterone Acetate; Drug Combinations; Drug Therapy, Combination; Ethi

2008
Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior.
    Fertility and sterility, 1995, Volume: 64, Issue:3

    Topics: Acne Vulgaris; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Femal

1995
Efficacy of flutamide versus spironolactone.
    Fertility and sterility, 1995, Volume: 63, Issue:3

    Topics: Contraceptives, Oral; Female; Flutamide; Hirsutism; Humans; Incidence; Menstruation Disturbances; Sp

1995
The use of antiandrogen flutamide in the treatment of hirsutism.
    Endocrine journal, 1994, Volume: 41, Issue:5

    Topics: Adult; Female; Flutamide; Hirsutism; Humans; Luteinizing Hormone; Progesterone

1994
Treatment of hirsutism with flutamide and a low-dosage oral contraceptive in polycystic ovarian disease patients.
    Fertility and sterility, 1994, Volume: 62, Issue:6

    Topics: Adolescent; Adult; Contraceptives, Oral; Desogestrel; Dose-Response Relationship, Drug; Drug Therapy

1994
Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism.
    Fertility and sterility, 1994, Volume: 61, Issue:4

    Topics: Adolescent; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Flutamide; Follic

1994
Clinical and endocrine effects of flutamide in hyperandrogenic women.
    Fertility and sterility, 1993, Volume: 60, Issue:5

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androgens; Estradiol; Female; Flutamide; Follicle S

1993
Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial.
    Fertility and sterility, 1994, Volume: 61, Issue:2

    Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Flutamide; Follicl

1994
Clinical efficacy and safety of low-dose flutamide alone and combined with an oral contraceptive for the treatment of idiopathic hirsutism.
    Clinical endocrinology, 1995, Volume: 43, Issue:5

    Topics: Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Drug Administration Schedule; Drug Ther

1995
The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism.
    Fertility and sterility, 1996, Volume: 66, Issue:2

    Topics: Adolescent; Adult; Androgen Antagonists; Androstenedione; Dose-Response Relationship, Drug; Estrogen

1996
Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1996, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Androgen Antagonists; Cyproterone; Female; Flutamide; Hirsutism; Hormones; Humans

1996
Androgen-receptor blockade does not impair bone mineral density in adolescent females.
    Calcified tissue international, 1997, Volume: 61, Issue:1

    Topics: Absorptiometry, Photon; Acne Vulgaris; Adolescent; Adult; Analysis of Variance; Androgen Antagonists

1997
Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1997, Volume: 11, Issue:4

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Androgen Antagonists; Androstenedione; Dehydroepiandrosterone S

1997
A comparison between two doses of flutamide (250 mg/d and 500 mg/d) in the treatment of hirsutism.
    Fertility and sterility, 1997, Volume: 68, Issue:4

    Topics: Adult; Androgen Antagonists; Dose-Response Relationship, Drug; Female; Flutamide; Hirsutism; Humans;

1997
[Finasteride and flutamide in the treatment of hirsutism].
    Minerva ginecologica, 1997, Volume: 49, Issue:10

    Topics: Administration, Oral; Adult; Androgen Antagonists; Dose-Response Relationship, Drug; Female; Finaste

1997
Prospective randomized study comparing the long-acting gonadotropin-releasing hormone agonist triptorelin, flutamide, and cyproterone acetate, used in combination with an oral contraceptive, in the treatment of hirsutism.
    Fertility and sterility, 1999, Volume: 71, Issue:1

    Topics: Adult; Androgen Antagonists; Body Mass Index; Contraceptives, Oral, Hormonal; Cyproterone Acetate; D

1999
Treatment of hirsutism: comparisons between different antiandrogens with central and peripheral effects.
    Fertility and sterility, 1999, Volume: 71, Issue:3

    Topics: Adolescent; Adult; Androgen Antagonists; Cyproterone Acetate; Female; Finasteride; Flutamide; Hirsut

1999
Spironolactone, but not flutamide, administration prevents bone loss in hyperandrogenic women treated with gonadotropin-releasing hormone agonist.
    The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:4

    Topics: Adult; Bone and Bones; Bone Density; Bone Resorption; Female; Flutamide; Hirsutism; Humans; Polycyst

1999
A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism.
    The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:4

    Topics: Adult; Cyproterone Acetate; Ethinyl Estradiol; Female; Finasteride; Flutamide; Hirsutism; Hormones;

1999
Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism.
    Journal of endocrinological investigation, 1999, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Androgen Antagonists; Androstenedione; Dehydroepiandrosterone Sulfate; Estradiol;

1999
Recurrence rate of hirsutism after 3 different antiandrogen therapies.
    Journal of the American Academy of Dermatology, 1999, Volume: 41, Issue:1

    Topics: Androgen Antagonists; Contraceptives, Oral; Cyproterone; Female; Flutamide; Hirsutism; Humans; Lutei

1999
Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism.
    Fertility and sterility, 1999, Volume: 72, Issue:1

    Topics: Adolescent; Adult; Androgen Antagonists; Androstane-3,17-diol; Body Mass Index; Enzyme Inhibitors; F

1999
Treatment with flutamide improves hyperinsulinemia in women with idiopathic hirsutism.
    Fertility and sterility, 1999, Volume: 72, Issue:3

    Topics: Adult; Androgen Antagonists; Blood Glucose; C-Peptide; Female; Flutamide; Follicle Stimulating Hormo

1999
Comparison of finasteride versus flutamide in the treatment of hirsutism.
    European journal of endocrinology, 1999, Volume: 141, Issue:4

    Topics: Adolescent; Adult; Androgen Antagonists; Enzyme Inhibitors; Female; Finasteride; Flutamide; Hirsutis

1999
Antiandrogen drugs lower serum prostate-specific antigen (PSA) levels in hirsute subjects: evidence that serum PSA is a marker of androgen action in women.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:1

    Topics: Adult; Androgen Antagonists; Androgens; Androstane-3,17-diol; Biomarkers; Double-Blind Method; Enzym

2000
Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:1

    Topics: Adult; Androgen Antagonists; Double-Blind Method; Female; Finasteride; Flutamide; Hair; Hirsutism; H

2000
A prospective, randomized trial comparing flutamide (250 mg/d) and finasteride (5 mg/d) in the treatment of hirsutism.
    Fertility and sterility, 2000, Volume: 73, Issue:5

    Topics: Adult; Androgen Antagonists; Body Mass Index; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Est

2000
Treatment of hirsutism with lowest-dose flutamide (62.5 mg/day).
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2000, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Androgen Antagonists; Female; Flutamide; Hirsutism; Hormones; Humans; Prospective

2000
Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:9

    Topics: Adolescent; Androgen Antagonists; Blood Glucose; Female; Flutamide; Glucose Tolerance Test; Hirsutis

2000
Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2000, Volume: 14, Issue:6

    Topics: Adult; Amenorrhea; Androgen Antagonists; Contraceptives, Oral, Combined; Cyproterone Acetate; Estrad

2000
Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism.
    Hormone research, 2001, Volume: 56, Issue:1-2

    Topics: Adult; Alanine Transaminase; Androgen Antagonists; Aspartate Aminotransferases; Dose-Response Relati

2001
Antiandrogens: clinical applications.
    The Journal of steroid biochemistry and molecular biology, 1990, Nov-20, Volume: 37, Issue:3

    Topics: Acne Vulgaris; Adult; Androgen Antagonists; Cyproterone; Cyproterone Acetate; Dermatitis, Seborrheic

1990

Other Studies

38 other studies available for flutamide and Hirsutism

ArticleYear
Polycystic ovarian syndrome: a second-take on flutamide.
    Fertility and sterility, 2023, Volume: 119, Issue:1

    Topics: Androgen Antagonists; Female; Flutamide; Hirsutism; Humans; Polycystic Ovary Syndrome

2023
Very low dose of flutamide in the treatment of hyperandrogenism.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:5

    Topics: Acne Vulgaris; Adolescent; Androgen Antagonists; Androstenes; Dose-Response Relationship, Drug; Drug

2018
Clinical efficacy of low dose flutamide plus Diane-35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome.
    Ginekologia polska, 2013, Volume: 84, Issue:4

    Topics: Adult; Androgen Antagonists; Cyproterone Acetate; Drug Administration Schedule; Drug Combinations; D

2013
Hirsutism - from diagnosis to use of antiandrogens.
    Frontiers of hormone research, 2013, Volume: 40

    Topics: Androgen Antagonists; Androstenes; Cyproterone Acetate; Female; Finasteride; Flutamide; Hirsutism; H

2013
Hyperinsulinaemic androgen excess in adolescent girls.
    Nature reviews. Endocrinology, 2014, Volume: 10, Issue:8

    Topics: Adolescent; Androgens; Drug Therapy, Combination; Dyslipidemias; Female; Flutamide; Hirsutism; Human

2014
Long-term satisfaction and tolerability with low-dose flutamide: a 20-year surveillance study on 120 hyperandrogenic women.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2016, Volume: 32, Issue:9

    Topics: Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Drug Therapy, Combination; Female; Flut

2016
The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism.
    Archives of gynecology and obstetrics, 2009, Volume: 279, Issue:3

    Topics: Adolescent; Adult; Alanine Transaminase; Androgen Antagonists; Aspartate Aminotransferases; Chemical

2009
[Low-dose flutamide in the treatment of hyperandrogenism in adolescents].
    Minerva pediatrica, 2008, Volume: 60, Issue:6

    Topics: Acne Vulgaris; Adolescent; Androgen Antagonists; Body Mass Index; Child; Female; Flutamide; Follow-U

2008
A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism.
    Journal of endocrinological investigation, 2009, Volume: 32, Issue:1

    Topics: Adult; Androgen Antagonists; Drug Therapy, Combination; Female; Finasteride; Flutamide; Hirsutism; H

2009
Low-dose flutamide for women with androgen excess: anti-androgenic efficacy and hepatic safety.
    Journal of endocrinological investigation, 2009, Volume: 32, Issue:1

    Topics: Androgen Antagonists; Androgens; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutis

2009
Hepatotoxicity during low-dose flutamide treatment for hirsutism.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2009, Volume: 25, Issue:7

    Topics: Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; H

2009
Retrospective observational study on the effects and tolerability of flutamide in a large population of patients with various kinds of hirsutism over a 15-year period.
    European journal of endocrinology, 2010, Volume: 163, Issue:1

    Topics: Female; Flutamide; Hirsutism; Humans; Retrospective Studies; Treatment Outcome

2010
Therapy: Low-dose flutamide for hirsutism: into the limelight, at last.
    Nature reviews. Endocrinology, 2010, Volume: 6, Issue:8

    Topics: Adult; Androgen Antagonists; Drug Administration Schedule; Female; Flutamide; Hirsutism; Humans; You

2010
The treatment of polycystic ovary syndrome.
    Minerva ginecologica, 2004, Volume: 56, Issue:1

    Topics: Adult; Androgen Antagonists; Cabergoline; Cardiovascular Diseases; Clomiphene; Cyproterone Acetate;

2004
Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination.
    Journal of endocrinological investigation, 2004, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Androgen Antagonists; Androgens; Androstenedione; Contraceptives, Oral, Hormonal;

2004
Hirsutism.
    The New England journal of medicine, 2006, Apr-06, Volume: 354, Issue:14

    Topics: Androgen Antagonists; Contraceptives, Oral; Drug Therapy, Combination; Female; Flutamide; Hirsutism;

2006
Flutamide hepatotoxicity.
    The Journal of urology, 1996, Volume: 155, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combi

1996
[Therapy of hirsutism with flutamide, a new non-steroidal antiandrogen].
    Ceska gynekologie, 1994, Volume: 59, Issue:5

    Topics: Female; Flutamide; Hirsutism; Humans

1994
Use of flutamide for self-induced androgen excess. A case report.
    The Journal of reproductive medicine, 1994, Volume: 39, Issue:10

    Topics: Adult; Clitoris; Edema; Female; Flutamide; Hirsutism; Humans; Hypertrophy; Paranoid Disorders; Testo

1994
Flutamide and hirsutism.
    Journal of endocrinological investigation, 1994, Volume: 17, Issue:8

    Topics: Female; Flutamide; Hirsutism; Humans; Publishing

1994
Safety of flutamide?
    Fertility and sterility, 1994, Volume: 62, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; Humans; Male

1994
The use of flutamide in the management of hirsutism.
    Journal of endocrinological investigation, 1994, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Female; Flutamide; Hirsutism; Hormones; Humans; Polycystic Ovary Syndrome; Sex Ho

1994
Hepatotoxicity complicating flutamide treatment of hirsutism.
    Annals of internal medicine, 1993, Dec-01, Volume: 119, Issue:11

    Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; Humans

1993
[Treatment of hirsutism].
    Nederlands tijdschrift voor geneeskunde, 1994, May-21, Volume: 138, Issue:21

    Topics: Chemical and Drug Induced Liver Injury; Flutamide; Hirsutism; Humans; Risk Factors

1994
The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism.
    Clinical endocrinology, 1993, Volume: 39, Issue:2

    Topics: Acne Vulgaris; Adult; Androgens; Dermatitis, Seborrheic; Female; Flutamide; Follicle Stimulating Hor

1993
Flutamide--effects and side effects.
    Fertility and sterility, 1993, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Female; Flutamide; Hirsutism; Humans

1993
Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1995, Volume: 9, Issue:3

    Topics: Adult; Androgen Antagonists; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Flutami

1995
Successful treatment of hirsutism in HAIR-AN syndrome using flutamide, spironolactone, and birth control therapy.
    Archives of dermatology, 1997, Volume: 133, Issue:4

    Topics: Acanthosis Nigricans; Adolescent; Androgen Antagonists; Contraceptives, Oral, Combined; Contraceptiv

1997
I've been trying to get rid of excess facial hair ever since I can remember. Is there any effective medication for this problem?
    Mayo Clinic health letter (English ed.), 1999, Volume: 17, Issue:2

    Topics: Androgen Antagonists; Female; Finasteride; Flutamide; Hirsutism; Humans

1999
Fulminant liver failure associated with flutamide therapy for hirsutism.
    Lancet (London, England), 1999, Mar-20, Volume: 353, Issue:9157

    Topics: Adolescent; Androgen Antagonists; Female; Flutamide; Hepatic Encephalopathy; Hirsutism; Humans; Live

1999
[Toxic hepatitis caused by flutamide and hirsutism].
    Gastroenterologia y hepatologia, 2000, Volume: 23, Issue:5

    Topics: Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; H

2000
[Hirsutism, flutamide and hepatotoxicity].
    Gastroenterologia y hepatologia, 2001, Volume: 24, Issue:4

    Topics: Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; H

2001
Flutamide-induced hepatotoxicity: report of a case series.
    Revista espanola de enfermedades digestivas, 2001, Volume: 93, Issue:7

    Topics: Adolescent; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Live

2001
Testosterone-secreting gonadotropin-responsive adrenal adenoma and its treatment with the antiandrogen flutamide.
    Journal of endocrinological investigation, 2001, Volume: 24, Issue:8

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Androgen Antagonists; Chorionic Gonadotropin; Dexam

2001
Treatment of hirsutism in women with flutamide.
    Fertility and sterility, 1992, Volume: 57, Issue:3

    Topics: Adult; Analysis of Variance; Androstane-3,17-diol; Androstenedione; Dehydroepiandrosterone; Dehydroe

1992
Flutamide in the treatment of hirsutism.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1991, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Female; Flutamide; Hirsutism; Humans

1991
[The effect of a peripheral androgenic blockade on plasma lipoproteins in hirsutism patients].
    Revista medica de Chile, 1990, Volume: 118, Issue:12

    Topics: Adult; Alanine Transaminase; Analysis of Variance; Anovulation; Dehydroepiandrosterone; Drug Evaluat

1990
Treatment of hirsutism with the pure antiandrogen flutamide.
    Journal of the American Academy of Dermatology, 1990, Volume: 23, Issue:3 Pt 1

    Topics: Adult; Female; Flutamide; Gonadal Steroid Hormones; Hirsutism; Humans

1990