Page last updated: 2024-10-27

flutamide and Genetic Predisposition

flutamide has been researched along with Genetic Predisposition in 3 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Research Excerpts

Excerpt	Relevance	Reference
"Since the majority of testicular cancers are derived from germ cells at the stage of transformation of primordial germ cell (PGC) into gonocytes, the increase has been attributed to maternal/fetal exposures to environmental factors."	1.38	Fetal radiation exposure induces testicular cancer in genetically susceptible mice. ( Comish, PB; Matin, A; Meistrich, ML; Shetty, G; Weng, CC, 2012)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	2 (66.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gruessner, C	1
Gruessner, A	1
Glaser, K	1
AbuShahin, N	1
Zhou, Y	1
Laughren, C	1
Wright, H	1
Pinkerton, S	1
Yi, X	1
Stoffer, J	1
Azodi, M	1
Zheng, W	1
Chambers, SK	1
Shetty, G	1
Comish, PB	1
Weng, CC	1
Matin, A	1
Meistrich, ML	1
Nuñez, JL	1
McCarthy, MM	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Prospective, Phase IIA Study of the Effect of Flutamide (125 MG/DAY) Taken for 6 Weeks on Expression of Potential Biomarkers of Flutamide Action in the Ovaries of Women at Increased Risk for Ovarian Cancer[NCT00699907]			Phase 2	127 participants (Actual)	Interventional	2005-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Colony Stimulating Factor (CSF-1) Expression in Ovarian Endosalpingiosis

"CSF-1 levels were measured by immunohistochemistry (IHC).~The modified H-Score assess extent of nuclear immunoreactivity applicable to steroid receptors.~The modified H-scores total range is 0-300. A lower modified H-score indicates weakly staining nuclei. A higher modified H-score indicated strongly staining nuclei.~This applies to all measures." (NCT00699907)
Timeframe: Surgery

Intervention	Modified H-Score (Median)
Treatment Arm	5
High Risk Arm	130
Low Risk Arm	50

Colony Stimulating Factor (CSF-1) Expression in Ovarian Epithelium

CSF-1 levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	0
High Risk Arm	50
Low Risk Arm	0

Colony Stimulating Factor (CSF-1) Expression in Ovarian Stroma

CSF-1 levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	5
High Risk Arm	40
Low Risk Arm	35

Colony Stimulating Factor-1 Receptor (CSF-1R) Expression in Ovarian Endosalpingiosis

CSF-1R levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	15
High Risk Arm	160
Low Risk Arm	75

Colony Stimulating Factor-1 Receptor (CSF-1R) Expression in Ovarian Epithelium

CSF-1R levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	0
High Risk Arm	40
Low Risk Arm	20

Colony Stimulating Factor-1 Receptor (CSF-1R) Expression in Ovarian Stroma

CSF-1R levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	20
High Risk Arm	40
Low Risk Arm	53

Tyrosine Kinase V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog-4 (ErbB4) Expression in Ovarian Endosalpingiosis

ErbB4 levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	5
High Risk Arm	60
Low Risk Arm	10

Tyrosine Kinase V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog-4 (ErbB4) Expression in Ovarian Epithelium

ErbB4 levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	0
High Risk Arm	55
Low Risk Arm	0

Tyrosine Kinase V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog-4 (ErbB4) Expression in Ovarian Stroma

ErbB4 levels were measured by immunohistochemistry (IHC). (NCT00699907)
Timeframe: Surgery

Intervention	Histo-score (H-Score) (Median)
Treatment Arm	10
High Risk Arm	90
Low Risk Arm	30

Trials

1 trial available for flutamide and Genetic Predisposition

Article	Year
Flutamide and biomarkers in women at high risk for ovarian cancer: preclinical and clinical evidence. Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:9 Topics: Adult; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Area Under Curve; Biomarkers,	2014

Other Studies

2 other studies available for flutamide and Genetic Predisposition

Article	Year
Fetal radiation exposure induces testicular cancer in genetically susceptible mice. PloS one, 2012, Volume: 7, Issue:2 Topics: Androgen Antagonists; Animals; Diethylstilbestrol; Estrogens, Non-Steroidal; Female; Fetus; Flutamid	2012
Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus. Experimental neurology, 2008, Volume: 210, Issue:2 Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Brain Damage, Chro	2008