flutamide has been researched along with Disease Models, Animal in 62 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin is commonly used to treat insulin resistance-glucose intolerance, and flutamide, an androgen receptor (AR) antagonist, is used to target hyperandrogenemia and dyslipidemia." | 7.91 | Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model. ( Diane, A; Ghosh, M; Kupreeva, M; Lehner, R; Proctor, S; Vine, D; Watts, R, 2019) |
| " PCOS induced rats with ovulation blockade, persistent estrus and polycystic ovary resumed estrous cycle in 3-4 days post noscapine administration (120 mg/kg bwt/day)." | 7.75 | Relevance of an opioid, noscapine in reducing cystogeneses in rat experimental model of polycystic ovary syndrome. ( Priyadarshani, A, 2009) |
| "To determine the effect of flutamide on vaginal histology, and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model." | 7.73 | Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight. ( Gumusalan, Y; Ozbag, D; Ozdemir, N; Saruhan, BG, 2005) |
| "The experimental model of hypospadias induced by flutamide is steadier and more suitable for popularization." | 7.72 | [A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004) |
| "Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients." | 5.51 | Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy. ( Gong, H; Kuang, H; Li, Y; Ling, Y; Liu, H; Qiao, B; Wu, W; Xu, J; Yang, B; Yu, D, 2019) |
| " Metformin is commonly used to treat insulin resistance-glucose intolerance, and flutamide, an androgen receptor (AR) antagonist, is used to target hyperandrogenemia and dyslipidemia." | 3.91 | Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model. ( Diane, A; Ghosh, M; Kupreeva, M; Lehner, R; Proctor, S; Vine, D; Watts, R, 2019) |
| " This study tested whether 1) in utero cotreatment of prenatally T-treated sheep with androgen antagonist (flutamide) or insulin sensitizer (rosiglitazone) prevents juvenile insulin resistance and adult changes in adipocyte size; and 2) visceral adiposity and insulin sensitivity are both unaltered during early adulthood, confirming the predicted developmental trajectory in this animal model." | 3.83 | Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. ( Beckett, E; Cardoso, RC; Chazenbalk, G; Dumesic, D; Keller, E; Madrigal, V; Moeller, J; Padmanabhan, V; Pease, A; Veiga-Lopez, A, 2016) |
| "The present study describes the role of the ubiquitin ligase Siah-2 and corepressor N-CoR in controlling androgen receptor (AR) and estrogen receptors (ERα and ERβ) signaling in an appropriate animal model (Fischer 344 female rats) of non-muscle invasive bladder cancer (NMIBC), especially under conditions of anti-androgen therapy with flutamide." | 3.81 | Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer. ( Apolinário, LM; Böckelmann, PK; da Silva Nunes, I; Duran, N; Fávaro, WJ; Garcia, PV, 2015) |
| "Flutamide failed to show any benefit to resuscitation in a model of severe injury and was associated with increased acidosis, hemodilution, and liver injury compared with standard crystalloid resuscitation." | 3.79 | Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model. ( Hempel, J; Hoffer, Z; Martin, M; Satterly, SA; Stallings, JD; Wingerd, M, 2013) |
| "Castrated and flutamide-treated male rats were significantly protected against trauma hemorrhagic shock (T/HS)-induced gut injury when compared with hormonally intact males." | 3.77 | Testosterone depletion or blockade in male rats protects against trauma hemorrhagic shock-induced distant organ injury by limiting gut injury and subsequent production of biologically active mesenteric lymph. ( Deitch, EA; Feketeova, E; Lu, Q; Palange, D; Qin, X; Reino, DC; Sheth, SU; Wei, D; Xu, DZ, 2011) |
| " PCOS induced rats with ovulation blockade, persistent estrus and polycystic ovary resumed estrous cycle in 3-4 days post noscapine administration (120 mg/kg bwt/day)." | 3.75 | Relevance of an opioid, noscapine in reducing cystogeneses in rat experimental model of polycystic ovary syndrome. ( Priyadarshani, A, 2009) |
| "Time-mated Sprague-Dawley female rats were injected subcutaneously with flutamide (75 mg/kg in sunflower oil) on days 16 to 19 of pregnancy." | 3.75 | The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development. ( Balic, A; Buraundi, S; Farmer, P; Hutson, J; Nation, T; Newgreen, D; Southwell, B, 2009) |
| "To determine the effect of flutamide on vaginal histology, and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model." | 3.73 | Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight. ( Gumusalan, Y; Ozbag, D; Ozdemir, N; Saruhan, BG, 2005) |
| "Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer, causes a temporary increase in transaminase and in some cases severe liver dysfunction." | 3.73 | Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice. ( Doi, M; Goda, R; Ichimura, E; Matsuzaki, Y; Nagai, D; Nishikawa, K; Tomura, A, 2006) |
| "The experimental model of hypospadias induced by flutamide is steadier and more suitable for popularization." | 3.72 | [A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004) |
| " A pilot study was undertaken to test the efficacy of flutamide (an antiandrogen) in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model of prostate cancer." | 3.70 | Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model. ( Greenberg, N; Kuliyev, E; Raghow, S; Steakley, M; Steiner, MS, 2000) |
| "05% BBN [N-butyl-N-(4-hydroxybutyl)nitrosamine] orally to 117 Wistar rats for 10 weeks, divided them into seven groups-control, surgical castration, finasteride (2 mg/kg), luteinizing hormone releasing hormone (LH-RH) agonist (1 mg/kg) flutamide (50 mg/kg), LH-RH agonist plus finasteride, and LH-RH agonist plus flutamide-, and then cystectomized them to investigate the incidence of bladder cancer on week 21; experiment 2: we administered 0." | 3.69 | Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in male rats. ( Akaza, H; Ami, Y; Ideyama, Y; Imada, S; Koiso, K; Takenaka, T, 1997) |
| "Postoperative pain was induced by a plantar incision and the study group received flutamide to block testosterone receptor." | 1.51 | Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain. ( Amaral, AG; Ashmawi, HA; Barbosa Neto, JO; Cartágenes, MDSS; Garcia, JBS; Onuchic, LF, 2019) |
| "Flutamide was metabolised to 2-hydroxyflutamide achieving steady-state plasma levels across the study duration and reached the spinal cord at pharmacologically active concentrations." | 1.51 | Androgen receptor antagonism accelerates disease onset in the SOD1 ( Boon, WC; Chiam, MDF; Djouma, E; Lau, CL; McLeod, VM; Roessner, U; Rupasinghe, TW; Turner, BJ, 2019) |
| "Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients." | 1.51 | Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy. ( Gong, H; Kuang, H; Li, Y; Ling, Y; Liu, H; Qiao, B; Wu, W; Xu, J; Yang, B; Yu, D, 2019) |
| "Flutamide treatment in LET females reversed elevated T levels and restored ovarian expression of Cyp17a1 (critical for androgen synthesis) to normal levels." | 1.48 | Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. ( Malik, S; Mellon, PL; Ryan, GE, 2018) |
| "Molecular apocrine breast cancer is an estrogen receptor negative subtype characterized by the over-expression of steroid response genes." | 1.36 | Inhibition of androgen receptor and Cdc25A phosphatase as a combination targeted therapy in molecular apocrine breast cancer. ( Liu, J; Naderi, A, 2010) |
| "Actions at ERbeta may underlie some antiseizure effects of T's metabolites." | 1.35 | Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta. ( Frye, CA; Rhodes, M; Ryan, A, 2009) |
| "In flutamide-treated rats, DNA synthesis was suppressed until day 6, similar suppression was observed in capsaicin-treated SD, and TS rats until day 4." | 1.33 | Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve. ( Bidarkar, SS; Donath, S; Farmer, PJ; Hutson, JM; Ng, SL; Sourial, M, 2005) |
| "Flutamide-treated males had significant elevation of serum testosterone, but their atrophied seminal vesicles strongly suggested that peripheral androgen effects were blocked." | 1.29 | Accelerated deaths from systemic lupus erythematosus in NZB x NZW F1 mice treated with the testosterone-blocking drug flutamide. ( Besch-Williford, CL; Keisler, DH; Walker, SE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.84) | 18.7374 |
| 1990's | 6 (9.68) | 18.2507 |
| 2000's | 21 (33.87) | 29.6817 |
| 2010's | 29 (46.77) | 24.3611 |
| 2020's | 3 (4.84) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Barbosa Neto, JO | 1 |
| Garcia, JBS | 1 |
| Cartágenes, MDSS | 1 |
| Amaral, AG | 1 |
| Onuchic, LF | 1 |
| Ashmawi, HA | 1 |
| Gisela S, B | 1 |
| M Virginia, A | 1 |
| Gabriela A, A | 1 |
| M Virginia, T | 1 |
| Enrique H, L | 1 |
| Laura, K | 1 |
| Véronica L, B | 1 |
| Rolon, S | 1 |
| Huynh, C | 1 |
| Guenther, M | 1 |
| Gardezi, M | 1 |
| Phillips, J | 1 |
| Gehrand, AL | 1 |
| Raff, H | 1 |
| Rübben, I | 1 |
| Stein, R | 1 |
| Ryan, GE | 1 |
| Malik, S | 1 |
| Mellon, PL | 1 |
| Kupreeva, M | 1 |
| Diane, A | 1 |
| Lehner, R | 1 |
| Watts, R | 1 |
| Ghosh, M | 1 |
| Proctor, S | 1 |
| Vine, D | 1 |
| McLeod, VM | 1 |
| Lau, CL | 1 |
| Chiam, MDF | 1 |
| Rupasinghe, TW | 1 |
| Roessner, U | 1 |
| Djouma, E | 1 |
| Boon, WC | 1 |
| Turner, BJ | 1 |
| Son, BK | 1 |
| Kojima, T | 1 |
| Ogawa, S | 1 |
| Akishita, M | 1 |
| Gong, H | 1 |
| Wu, W | 1 |
| Xu, J | 1 |
| Yu, D | 1 |
| Qiao, B | 1 |
| Liu, H | 1 |
| Yang, B | 1 |
| Li, Y | 1 |
| Ling, Y | 1 |
| Kuang, H | 1 |
| Goda, K | 1 |
| Muta, K | 1 |
| Yasui, Y | 1 |
| Oshida, S | 1 |
| Kitatani, K | 1 |
| Takekoshi, S | 1 |
| Satterly, SA | 1 |
| Martin, M | 1 |
| Wingerd, M | 1 |
| Hempel, J | 1 |
| Hoffer, Z | 1 |
| Stallings, JD | 1 |
| Renier, KJ | 1 |
| Troxell-Smith, SM | 2 |
| Johansen, JA | 2 |
| Katsuno, M | 2 |
| Adachi, H | 2 |
| Sobue, G | 2 |
| Chua, JP | 1 |
| Sun Kim, H | 1 |
| Lieberman, AP | 2 |
| Breedlove, SM | 2 |
| Jordan, CL | 2 |
| Blesson, CS | 1 |
| Chinnathambi, V | 1 |
| Hankins, GD | 1 |
| Yallampalli, C | 1 |
| Sathishkumar, K | 1 |
| Garcia, PV | 1 |
| Apolinário, LM | 1 |
| Böckelmann, PK | 1 |
| da Silva Nunes, I | 1 |
| Duran, N | 1 |
| Fávaro, WJ | 1 |
| Steffens, JP | 1 |
| Coimbra, LS | 1 |
| Rossa, C | 1 |
| Kantarci, A | 1 |
| Van Dyke, TE | 1 |
| Spolidorio, LC | 1 |
| da Silva, VA | 1 |
| Dantas, Mde S | 1 |
| Silva, LA | 1 |
| Carneiro, JG | 1 |
| Schamber-Reis, BL | 1 |
| Cardoso, RC | 2 |
| Veiga-Lopez, A | 1 |
| Moeller, J | 2 |
| Beckett, E | 1 |
| Pease, A | 1 |
| Keller, E | 1 |
| Madrigal, V | 1 |
| Chazenbalk, G | 1 |
| Dumesic, D | 1 |
| Padmanabhan, V | 2 |
| Davis, JP | 1 |
| Salmon, M | 1 |
| Pope, NH | 1 |
| Lu, G | 1 |
| Su, G | 1 |
| Meher, A | 1 |
| Ailawadi, G | 1 |
| Upchurch, GR | 1 |
| Dasinger, JH | 1 |
| Intapad, S | 1 |
| Rudsenske, BR | 1 |
| Davis, GK | 1 |
| Newsome, AD | 1 |
| Alexander, BT | 1 |
| Kita, DH | 1 |
| Meyer, KB | 1 |
| Venturelli, AC | 1 |
| Adams, R | 1 |
| Machado, DL | 1 |
| Morais, RN | 1 |
| Swan, SH | 1 |
| Gennings, C | 1 |
| Martino-Andrade, AJ | 1 |
| Burns, A | 1 |
| Skinner, DC | 1 |
| Priyadarshani, A | 1 |
| Reznikov, OH | 1 |
| Borys, OM | 1 |
| Nosenko, ND | 1 |
| Sinitsyn, PV | 2 |
| Tarasenko, LV | 2 |
| Poliakova, LI | 1 |
| Frye, CA | 2 |
| Ryan, A | 1 |
| Rhodes, M | 1 |
| Nation, T | 1 |
| Balic, A | 1 |
| Buraundi, S | 1 |
| Farmer, P | 1 |
| Newgreen, D | 1 |
| Southwell, B | 1 |
| Hutson, J | 1 |
| Crabtree, JS | 1 |
| Kilbourne, EJ | 1 |
| Peano, BJ | 1 |
| Chippari, S | 1 |
| Kenney, T | 1 |
| McNally, C | 1 |
| Wang, W | 1 |
| Harris, HA | 1 |
| Winneker, RC | 1 |
| Nagpal, S | 1 |
| Thompson, CC | 1 |
| Walker, WH | 1 |
| Cray, J | 1 |
| Burrows, AM | 1 |
| Vecchione, L | 1 |
| Lensie, E | 1 |
| Decesare, GE | 1 |
| Campbell, A | 1 |
| Finegold, DN | 2 |
| Losee, JE | 2 |
| Siegel, MI | 2 |
| Cooper, GM | 2 |
| Mooney, MP | 2 |
| Naderi, A | 1 |
| Liu, J | 1 |
| Yu, Z | 1 |
| Mo, K | 1 |
| Monks, DA | 1 |
| Cray, JJ | 1 |
| Durham, EL | 1 |
| Smalley, MA | 1 |
| Kurokawa, S | 1 |
| Kojima, Y | 1 |
| Mizuno, K | 1 |
| Kamisawa, H | 1 |
| Tozawa, K | 1 |
| Kohri, K | 1 |
| Hayashi, Y | 1 |
| Sheth, SU | 1 |
| Palange, D | 1 |
| Xu, DZ | 1 |
| Wei, D | 1 |
| Feketeova, E | 1 |
| Lu, Q | 1 |
| Reino, DC | 1 |
| Qin, X | 1 |
| Deitch, EA | 1 |
| Doyu, M | 1 |
| Minamiyama, M | 1 |
| Sang, C | 1 |
| Kobayashi, Y | 1 |
| Inukai, A | 1 |
| Reznikov, AG | 1 |
| Polyakova, LI | 1 |
| He, H | 1 |
| Zhang, W | 1 |
| Zhu, J | 1 |
| Ng, SL | 1 |
| Bidarkar, SS | 1 |
| Sourial, M | 2 |
| Farmer, PJ | 2 |
| Donath, S | 1 |
| Hutson, JM | 2 |
| Nagao, S | 1 |
| Kusaka, M | 1 |
| Nishii, K | 1 |
| Marunouchi, T | 1 |
| Kurahashi, H | 1 |
| Takahashi, H | 1 |
| Grantham, J | 1 |
| Saruhan, BG | 1 |
| Ozbag, D | 1 |
| Gumusalan, Y | 1 |
| Ozdemir, N | 1 |
| Matsuzaki, Y | 1 |
| Nagai, D | 1 |
| Ichimura, E | 1 |
| Goda, R | 1 |
| Tomura, A | 1 |
| Doi, M | 1 |
| Nishikawa, K | 1 |
| Oliveira, SM | 1 |
| Leite Vilamaior, PS | 1 |
| Corradi, LS | 1 |
| Góes, RM | 1 |
| Taboga, SR | 1 |
| Shimizu, T | 1 |
| Yu, HP | 1 |
| Hsieh, YC | 1 |
| Choudhry, MA | 1 |
| Suzuki, T | 1 |
| Bland, KI | 1 |
| Chaudry, IH | 1 |
| Cho, YM | 1 |
| Takahashi, S | 1 |
| Asamoto, M | 1 |
| Suzuki, S | 1 |
| Tang, M | 1 |
| Shirai, T | 1 |
| Akçora, B | 1 |
| Altuğ, E | 1 |
| Kontaş, T | 1 |
| Hakverdi, S | 1 |
| Temiz, A | 1 |
| Harnaen, EJ | 1 |
| Na, AF | 1 |
| Shenker, NS | 1 |
| Southwell, BR | 1 |
| Nuñez, JL | 1 |
| McCarthy, MM | 1 |
| Isaacs, JT | 1 |
| Weissman, RM | 1 |
| Coffey, DS | 1 |
| Scott, WW | 1 |
| el Etreby, MF | 1 |
| Habenicht, UF | 1 |
| Tutrone, RF | 1 |
| Ball, RA | 1 |
| Ornitz, DM | 1 |
| Leder, P | 1 |
| Richie, JP | 1 |
| Walker, SE | 1 |
| Besch-Williford, CL | 1 |
| Keisler, DH | 1 |
| Ruiz, A | 1 |
| Aguilar, R | 1 |
| Tébar, AM | 1 |
| Gaytán, F | 1 |
| Sánchez-Criado, JE | 1 |
| Imada, S | 1 |
| Akaza, H | 1 |
| Ami, Y | 1 |
| Koiso, K | 1 |
| Ideyama, Y | 1 |
| Takenaka, T | 1 |
| O'Connor, JC | 1 |
| Frame, SR | 1 |
| Davis, LG | 1 |
| Cook, JC | 1 |
| Yamada, T | 1 |
| Kunimatsu, T | 1 |
| Sako, H | 1 |
| Yabushita, S | 1 |
| Sukata, T | 1 |
| Okuno, Y | 1 |
| Matsuo, M | 1 |
| Dobson, CC | 1 |
| Reid, O | 1 |
| Bennett, NK | 1 |
| McDonald, SW | 1 |
| Raghow, S | 1 |
| Kuliyev, E | 1 |
| Steakley, M | 1 |
| Greenberg, N | 1 |
| Steiner, MS | 1 |
| Zakaria, O | 1 |
| Shono, T | 1 |
| Imajima, T | 1 |
| Suita, S | 1 |
| Sandberg, AA | 1 |
| Uzunova, A | 1 |
| Ramey, E | 1 |
| Ramwell, PW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical, Microbiologic and Immunologic Profile of the Periodontal Condition in Hypogonadic Men[NCT03176537] | Phase 4 | 0 participants (Actual) | Interventional | 2017-05-01 | Withdrawn (stopped due to No eligible participants for the RCT were found) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for flutamide and Disease Models, Animal
| Article | Year |
|---|---|
[Hypospadias : Insights and challenges].
Topics: Animals; Disease Models, Animal; Female; Flutamide; Humans; Hypospadias; Male; Mice; Plastic Surgery | 2017 |
Effects and mechanisms of progestogens and androgens in ictal activity.
Topics: Androgen Antagonists; Androgens; Animals; Anticonvulsants; Disease Models, Animal; Female; Flutamide | 2010 |
The function and the role of aromatase inhibitors in the treatment of BPH.
Topics: Androgens; Androstenedione; Animals; Aromatase Inhibitors; Clinical Trials as Topic; Disease Models, | 1994 |
Potential test systems for chemotherapeutic agents against prostatic cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; Antineoplastic Agents; Arginase; Dihydrot | 1975 |
58 other studies available for flutamide and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain.
Topics: Androgens; Animals; Behavior, Animal; Disease Models, Animal; Flutamide; Gene Expression Regulation; | 2019 |
Androgen receptor and uterine histoarchitecture in a PCOS rat model.
Topics: Animals; Animals, Newborn; Aquaporins; Collagen; Dehydroepiandrosterone; Disease Models, Animal; Est | 2020 |
Insulin and glucose responses to hypoxia in male and female neonatal rats: Effects of the androgen receptor antagonist flutamide.
Topics: Androgen Receptor Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Flutamide; | 2021 |
Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.
Topics: Adipocytes; Androgen Antagonists; Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal | 2018 |
Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model.
Topics: Androgen Antagonists; Animals; Apolipoprotein B-100; Apolipoprotein B-48; Apolipoproteins B; Blood G | 2019 |
Androgen receptor antagonism accelerates disease onset in the SOD1
Topics: Amyotrophic Lateral Sclerosis; Androgen Receptor Antagonists; Animals; Disease Models, Animal; Disea | 2019 |
Testosterone inhibits aneurysm formation and vascular inflammation in male mice.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure | 2019 |
Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy.
Topics: Androgen Antagonists; Animals; Decidua; Disease Models, Animal; Embryo Implantation; Female; Flutami | 2019 |
Selenium and Glutathione-Depleted Rats as a Sensitive Animal Model to Predict Drug-Induced Liver Injury in Humans.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flutamide; Glutathione; Mal | 2019 |
Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model.
Topics: Acidosis; Androgen Antagonists; Animals; Crystalloid Solutions; Cyclodextrins; Disease Models, Anima | 2013 |
Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.
Topics: Androgen Antagonists; Androgens; Animals; Blotting, Western; Bulbo-Spinal Atrophy, X-Linked; Disease | 2014 |
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.
Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.
Topics: Administration, Intravesical; Androgen Antagonists; Animals; Antineoplastic Combined Chemotherapy Pr | 2015 |
Androgen receptors and experimental bone loss - an in vivo and in vitro study.
Topics: Alveolar Bone Loss; Androgen Receptor Antagonists; Animals; Disease Models, Animal; Flutamide; In Vi | 2015 |
Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides: A Preliminary Study.
Topics: Androgen Antagonists; Animals; Body Weight; Brain; Cell Adhesion Molecules, Neuronal; Cerebellum; Cp | 2015 |
Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep.
Topics: Adiposity; Animals; Disease Models, Animal; Embryonic Development; Female; Flutamide; Insulin Resist | 2016 |
Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation.
Topics: Androgen Antagonists; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cytokines; Disease Mode | 2016 |
Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted Rats.
Topics: Animals; Animals, Newborn; Birth Weight; Blood Pressure Determination; Disease Models, Animal; Femal | 2016 |
Manipulation of pre and postnatal androgen environments and anogenital distance in rats.
Topics: Androgen Antagonists; Androgens; Animals; Diethylhexyl Phthalate; Disease Models, Animal; Dose-Respo | 2016 |
Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS.
Topics: Androgen Antagonists; Androgens; Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; F | 2016 |
Relevance of an opioid, noscapine in reducing cystogeneses in rat experimental model of polycystic ovary syndrome.
Topics: Analgesics, Opioid; Androgen Antagonists; Animals; Cysts; Disease Models, Animal; Dose-Response Rela | 2009 |
[Enhancing effect of androgen receptor antagonist on gonadotropic inductors of ovulation in rats with polycystic ovaries].
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Anovulation; Chorionic Gonadotropin; D | 2009 |
Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta.
Topics: Analysis of Variance; Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Disease | 2009 |
The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Division; Cell Movement; Cryptorchidism; Disea | 2009 |
A mouse model of androgenetic alopecia.
Topics: Alopecia; Androgen Antagonists; Androgens; Animals; beta Catenin; Blotting, Western; Cell Line; Cell | 2010 |
Is the "comb over" dying? A mouse model for male pattern baldness (androgenic alopecia).
Topics: Alopecia; Androgen Antagonists; Androgens; Animals; beta Catenin; Dihydrotestosterone; Disease Model | 2010 |
Effects of flutamide therapy on craniofacial growth and development in a model of craniosynostosis.
Topics: Analysis of Variance; Animals; Cranial Sutures; Craniosynostoses; Disease Models, Animal; Flutamide; | 2010 |
Inhibition of androgen receptor and Cdc25A phosphatase as a combination targeted therapy in molecular apocrine breast cancer.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Antineoplastic Combined Chemotherapy P | 2010 |
Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy.
Topics: Alleles; Anatomy, Cross-Sectional; Androgen Antagonists; Animals; Behavior, Animal; Bulbo-Spinal Atr | 2011 |
The effects of testosterone on craniosynostotic calvarial cells: a test of the gene/environmental model of craniofacial anomalies.
Topics: Alkaline Phosphatase; Androgen Antagonists; Androgens; Animals; Biomarkers; Cell Culture Techniques; | 2011 |
Association of prolactin-induced protein with preputial development of hypospadias.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Blotting, Western; Carrier Proteins; Case-Control S | 2012 |
Testosterone depletion or blockade in male rats protects against trauma hemorrhagic shock-induced distant organ injury by limiting gut injury and subsequent production of biologically active mesenteric lymph.
Topics: Animals; Castration; Disease Models, Animal; Flutamide; Gastrointestinal Tract; Lung Injury; Lymph; | 2011 |
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.
Topics: Androgen Antagonists; Animals; Disease Models, Animal; Female; Flutamide; Humans; Leuprolide; Male; | 2003 |
Neuroendocrine mechanisms of development of experimental hyperandrogen-induced anovulation.
Topics: Androgen Antagonists; Androgens; Animals; Anovulation; Disease Models, Animal; Estradiol; Estrous Cy | 2003 |
[A mouse model of hypospadias induced by flutamide].
Topics: Androgen Antagonists; Animals; Disease Models, Animal; Female; Fetus; Flutamide; Hypospadias; Male; | 2004 |
Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Calcitonin Gene-Re | 2005 |
Androgen receptor pathway in rats with autosomal dominant polycystic kidney disease.
Topics: Androgen Antagonists; Animals; Cell Proliferation; Dihydrotestosterone; Disease Models, Animal; Dise | 2005 |
Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight.
Topics: Androgen Antagonists; Animals; Body Weight; Disease Models, Animal; Female; Flutamide; Immunohistoch | 2005 |
Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice.
Topics: Alanine Transaminase; Amino Acids; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; C | 2006 |
Cellular and extracellular behavior in the gerbil (Meriones unguiculatus) ventral prostate following different types of castration and the consequences of testosterone replacement.
Topics: Acid Phosphatase; Androgen Antagonists; Animals; Cyproterone; Disease Models, Animal; Endoplasmic Re | 2007 |
Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway.
Topics: Abdominal Injuries; Androgen Antagonists; Animals; Chemokine CXCL1; Chemokines, CXC; Disease Models, | 2007 |
Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Animals, Genetically Modified; Antigens, Viral, Tumor | 2007 |
Orchiectomy or testosterone receptor blockade reduces intestinal mucosal damage caused by ischemia-reperfusion insult.
Topics: Analysis of Variance; Androgen Antagonists; Animals; Disease Models, Animal; Flutamide; Intestinal M | 2008 |
The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the rat.
Topics: Abdominal Muscles; Animals; Animals, Newborn; Cryptorchidism; Disease Models, Animal; Female; Flutam | 2007 |
Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Brain Damage, Chro | 2008 |
Concepts in prostatic cancer biology: Dunning R-3327 H, HI, and AT tumors.
Topics: Acid Phosphatase; Adenocarcinoma; Animals; Castration; Diethylstilbestrol; Disease Models, Animal; F | 1980 |
Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Azasteroids; Dihydrotestosterone; Disease Models | 1993 |
Accelerated deaths from systemic lupus erythematosus in NZB x NZW F1 mice treated with the testosterone-blocking drug flutamide.
Topics: Albuminuria; Animals; Antibodies, Antinuclear; Disease Models, Animal; Estradiol; Female; Flutamide; | 1994 |
RU486-treated rats show endocrine and morphological responses to therapies analogous to responses of women with polycystic ovary syndrome treated with similar therapies.
Topics: Androgen Antagonists; Animals; Bromocriptine; Disease Models, Animal; Dopamine Agonists; Estrogen An | 1996 |
Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in male rats.
Topics: Administration, Oral; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Antineoplastic | 1997 |
Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay.
Topics: Animals; Body Weight; Dichlorodiphenyl Dichloroethylene; Disease Models, Animal; Flutamide; Gonadal | 1999 |
Comparative evaluation of a 5-day Hershberger assay utilizing mature male rats and a pubertal male assay for detection of flutamide's antiandrogenic activity.
Topics: Androgen Antagonists; Animals; Disease Models, Animal; Evaluation Studies as Topic; Flutamide; Lutei | 2000 |
Effect of vasectomy on the seminiferous tubule boundary zone in the Albino Swiss rat.
Topics: Androgen Antagonists; Animals; Basement Membrane; Disease Models, Animal; Flutamide; Male; Microscop | 2000 |
Efficacious chemoprevention of primary prostate cancer by flutamide in an autochthonous transgenic model.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Anticarcinogenic Agents; Blotting, Western; Crosses, | 2000 |
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Disease Models, Animal; Female; Fertility; Flutamide; | 2000 |
Effect of testosterone, sex and age on experimentally induced arterial thrombosis.
Topics: Aging; Animals; Disease Models, Animal; Estradiol; Female; Flutamide; Male; Rabbits; Rats; Sex; Test | 1976 |