flutamide has been researched along with Delayed Effects, Prenatal Exposure in 79 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choose 7-week-old ICR mice, female mice were randomly divided into experimental group and control group after pregnancy, thenflutamide was orally administered to pregnant mice with dose 300 mg/( kg·d) during gestation days 12-18, while the control group was treated with equal volume of soybean oil." | 7.88 | [Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring]. ( Wen, K; Yang, J; Zhou, X; Zhu, Y, 2018) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 7.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 7.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| "Choose 7-week-old ICR mice, female mice were randomly divided into experimental group and control group after pregnancy, thenflutamide was orally administered to pregnant mice with dose 300 mg/( kg·d) during gestation days 12-18, while the control group was treated with equal volume of soybean oil." | 3.88 | [Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring]. ( Wen, K; Yang, J; Zhou, X; Zhu, Y, 2018) |
| " This study tested whether 1) in utero cotreatment of prenatally T-treated sheep with androgen antagonist (flutamide) or insulin sensitizer (rosiglitazone) prevents juvenile insulin resistance and adult changes in adipocyte size; and 2) visceral adiposity and insulin sensitivity are both unaltered during early adulthood, confirming the predicted developmental trajectory in this animal model." | 3.83 | Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. ( Beckett, E; Cardoso, RC; Chazenbalk, G; Dumesic, D; Keller, E; Madrigal, V; Moeller, J; Padmanabhan, V; Pease, A; Veiga-Lopez, A, 2016) |
| " Pregnant females received daily injections of the androgen receptor antagonist flutamide from day 12 of pregnancy until pups were born." | 3.73 | Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats. ( Camacho, FJ; Domínguez-Salazar, E; Paredes, RG, 2005) |
| " A total of 59 subjects (5-8 per treatment group) received exogenous androgen (testosterone enanthate), an anti-androgen (flutamide) or vehicle injections (DMSO) for 30 or 35 days during the second (early) or third (late) trimester of pregnancy." | 3.73 | Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: life history differences and effects of prenatal androgens. ( Gouzoules, H; Tomaszycki, ML; Wallen, K, 2005) |
| "The incidence of hypospadias increased with the dose of flutamide (0, 29." | 3.73 | [Impact of flutamide on sex differentiation in rats]. ( Li, Y; Liang, Y; Wang, WD; Wu, DS; Zhang, H, 2006) |
| "The role of prenatal androgen on the differentiation of sexually dimorphic juvenile play and adult copulatory patterns was evaluated in male offspring of rats injected with 5 mg of the androgen receptor blocker flutamide (4'-nitro-3'-trifluoromethylisobutyranilide) from Days 11-21 of pregnancy." | 3.72 | Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide. ( Bartke, A; Casto, JM; Ward, OB, 2003) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 3.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 3.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| " Pregnant females received exogenous androgen (testosterone enanthate), an androgen antagonist (flutamide), or vehicle injections for 30 or 35 days during the second (early) or third (late) trimester of pregnancy." | 3.71 | Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens. ( Davis, JE; Gouzoules, H; Tomaszycki, ML; Wallen, K, 2001) |
| " Female Wistar (W) and Sprague-Dawley (SD) rats were exposed to the anti-androgen flutamide prenatally (days 11-22 of pregnancy) and/or neonatally (days 1-10)." | 3.68 | Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats. ( Brand, T; Slob, AK, 1991) |
| "Flutamide was injected into pregnant gilts between Days 80 and 88 of gestation and into female piglets between Days 2 and 10 postnatally." | 2.77 | Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure. ( Duda, M; Grzesiak, M; Knapczyk-Stwora, K; Slomczynska, M, 2012) |
| " A non-monotonic dose-response relationship was not evident." | 1.46 | Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats. ( Buesen, R; Fussell, KC; Gröters, S; Jiang, X; Melching-Kollmuss, S; Schneider, S; Strauss, V; van Ravenzwaay, B, 2017) |
| "Flutamide treatment increased circulating testosterone yet also reduced seminal vesicle weight due to local antagonism of androgen receptor." | 1.42 | Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action. ( Cruickshanks, L; McKinnell, C; Milne, L; Mitchell, RT; Mungall, W; Sharpe, RM; Smith, LB, 2015) |
| "Flutamide treatment (10 mg/kg/day subcutaneously for 10 days) reduced mean arterial pressure in protein-restricted offspring but was without significant effect in controls." | 1.42 | Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring. ( Balakrishnan, MP; Sathishkumar, K; Yallampalli, C, 2015) |
| "Since the majority of testicular cancers are derived from germ cells at the stage of transformation of primordial germ cell (PGC) into gonocytes, the increase has been attributed to maternal/fetal exposures to environmental factors." | 1.38 | Fetal radiation exposure induces testicular cancer in genetically susceptible mice. ( Comish, PB; Matin, A; Meistrich, ML; Shetty, G; Weng, CC, 2012) |
| "Flutamide treated rats presented reductions in weight of testes and prostate, percentage of normal spermatozoa, spermatozoa concentration, testicular sperm production, and testosterone level." | 1.37 | Copulatory efficiency and fertility in male rats exposed perinatally to flutamide. ( Garcia, PC; Leonelli, C; Pereira, OC, 2011) |
| "Flutamide was injected into pregnant gilts between days 80 and 88 of gestation and into female piglets between days 2 and 10 posnatally." | 1.37 | Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin 43 gene expression in adult porcine ovary. ( Bilinska, B; Duda, M; Durlej, M; Hejmej, A; Knapczyk-Stwora, K; Kopera-Sobota, I; Slomczynska, M, 2011) |
| "In flutamide-treated rats, DNA synthesis was suppressed until day 6, similar suppression was observed in capsaicin-treated SD, and TS rats until day 4." | 1.33 | Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve. ( Bidarkar, SS; Donath, S; Farmer, PJ; Hutson, JM; Ng, SL; Sourial, M, 2005) |
| "Flutamide is a drug with antiandrogen effects that are mediated through androgen receptors (ARs)." | 1.33 | Evaluation of general behavior, memory, learning performance, and brain sexual differentiation in F1 offspring males of rats treated with flutamide during late gestation. ( Fujii, Y; Goto, K; Hashi, M; Koizumi, K; Ohbo, N; Ohta, Y; Saika, O; Saito, K; Suzuki, H; Suzuki, K, 2005) |
| "Flutamide treatment impaired differentiation of inner stromal cells, shown by decreased expression of smooth muscle actin, before effects were noted in the epithelium, consistent with androgens driving WD development via stromal-epithelial interactions." | 1.33 | Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide. ( Marchetti, NI; Saunders, PT; Sharpe, RM; Welsh, M, 2006) |
| " Furthermore, these data suggest that dose-response studies utilizing late gestational exposure to endocrine-active compounds may be more robust than the traditional or EPA-modified multigeneration protocols in identifying adverse effects." | 1.31 | Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. ( Barlow, NJ; Foster, PM; Gaido, KW; Maness, SC; McIntyre, BS; Wallace, DG, 2000) |
| " The chemical was dosed by gavage to pregnant dams at 10 or 100 mg/kg body wt from gestation day 14 to 18." | 1.30 | Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE. ( Archibeque-Engle, S; Casanova, M; Fan, LQ; Heck, HA; Sar, M; You, L, 1998) |
| "Flutamide treatment resulted in higher basal levels of testosterone and stress levels of corticosterone compared to vehicle treatment, and there was no interaction of treatment with age at time of treatment." | 1.30 | Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats. ( Mahoney, E; McCormick, CM, 1999) |
| " Pregnant Long-Evans rats were dosed by gavage from Gestation Day 14 to 18 at 0, 10 (low dose), or 100 (high dose) mg DDE, or 40 mg flutamide/kg body wt (bw)/day (in utero treatment)." | 1.30 | In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation. ( Brenneman, KA; Heck, H; You, L, 1999) |
| "Cryptorchidism was enhanced when rats were treated postnatally with testosterone or oestradiol." | 1.28 | Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide. ( van der Schoot, P, 1992) |
| " However, they were no less receptive than control females in response to a high (15 micrograms/kg) dosage of EB." | 1.27 | Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes. ( Baum, MJ; Tobet, SA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.33) | 18.7374 |
| 1990's | 13 (16.46) | 18.2507 |
| 2000's | 35 (44.30) | 29.6817 |
| 2010's | 23 (29.11) | 24.3611 |
| 2020's | 3 (3.80) | 2.80 |
| Authors | Studies |
|---|---|
| Schreiber, E | 2 |
| Garcia, T | 1 |
| González, N | 1 |
| Esplugas, R | 1 |
| Sharma, RP | 1 |
| Torrente, M | 2 |
| Kumar, V | 2 |
| Bovee, T | 2 |
| Katsanou, ES | 2 |
| Machera, K | 2 |
| Domingo, JL | 2 |
| Gómez, M | 1 |
| Batakis, P | 1 |
| Spyropoulou, A | 1 |
| Gómez, MM | 1 |
| Yu, H | 1 |
| Zhou, X | 2 |
| Zhang, Y | 1 |
| Wen, K | 2 |
| Yan, Z | 1 |
| Fu, H | 1 |
| Zhu, Y | 2 |
| Zacharia, LC | 1 |
| Huber, SE | 2 |
| Zoicas, I | 1 |
| Reichel, M | 1 |
| Mühle, C | 1 |
| Büttner, C | 1 |
| Ekici, AB | 1 |
| Eulenburg, V | 1 |
| Lenz, B | 2 |
| Kornhuber, J | 2 |
| Müller, CP | 2 |
| Schneider, S | 1 |
| Fussell, KC | 1 |
| Melching-Kollmuss, S | 1 |
| Buesen, R | 1 |
| Gröters, S | 1 |
| Strauss, V | 1 |
| Jiang, X | 1 |
| van Ravenzwaay, B | 1 |
| Yang, J | 1 |
| Pike, JW | 1 |
| McDowell, E | 1 |
| McCahan, SM | 1 |
| Johnson, KJ | 1 |
| Mitchell, RT | 1 |
| Mungall, W | 1 |
| McKinnell, C | 2 |
| Sharpe, RM | 5 |
| Cruickshanks, L | 1 |
| Milne, L | 1 |
| Smith, LB | 1 |
| Blesson, CS | 1 |
| Chinnathambi, V | 1 |
| Hankins, GD | 1 |
| Yallampalli, C | 2 |
| Sathishkumar, K | 2 |
| Balakrishnan, MP | 1 |
| Padmanabhan, V | 3 |
| Veiga-Lopez, A | 2 |
| Herkimer, C | 1 |
| Abi Salloum, B | 1 |
| Moeller, J | 3 |
| Beckett, E | 2 |
| Sreedharan, R | 1 |
| Cardoso, RC | 2 |
| Pease, A | 1 |
| Keller, E | 1 |
| Madrigal, V | 1 |
| Chazenbalk, G | 1 |
| Dumesic, D | 1 |
| Kita, DH | 1 |
| Meyer, KB | 1 |
| Venturelli, AC | 1 |
| Adams, R | 1 |
| Machado, DL | 1 |
| Morais, RN | 1 |
| Swan, SH | 1 |
| Gennings, C | 1 |
| Martino-Andrade, AJ | 1 |
| Burns, A | 1 |
| Skinner, DC | 1 |
| Anway, MD | 1 |
| Rekow, SS | 1 |
| Skinner, MK | 1 |
| Inawaka, K | 1 |
| Kawabe, M | 1 |
| Takahashi, S | 1 |
| Doi, Y | 1 |
| Tomigahara, Y | 1 |
| Tarui, H | 1 |
| Abe, J | 1 |
| Kawamura, S | 1 |
| Shirai, T | 1 |
| Macleod, DJ | 1 |
| Welsh, M | 3 |
| Fisken, M | 1 |
| Scott, HM | 3 |
| Hutchison, GR | 2 |
| Drake, AJ | 1 |
| van den Driesche, S | 1 |
| Auharek, SA | 1 |
| de Franca, LR | 1 |
| Jobling, MS | 1 |
| Knapczyk-Stwora, K | 3 |
| Durlej, M | 2 |
| Bilinska, B | 4 |
| Slomczynska, M | 3 |
| Kim, TS | 1 |
| Jung, KK | 1 |
| Kim, SS | 1 |
| Kang, IH | 1 |
| Baek, JH | 1 |
| Nam, HS | 1 |
| Hong, SK | 1 |
| Lee, BM | 1 |
| Hong, JT | 1 |
| Oh, KW | 1 |
| Kim, HS | 1 |
| Han, SY | 1 |
| Kang, TS | 1 |
| Leonelli, C | 1 |
| Garcia, PC | 1 |
| Pereira, OC | 1 |
| Duda, M | 2 |
| Kopera-Sobota, I | 2 |
| Hejmej, A | 2 |
| Lydka, M | 2 |
| Kotula-Balak, M | 2 |
| Chojnacka, K | 1 |
| Zak, D | 1 |
| Kopera, I | 1 |
| Shetty, G | 1 |
| Comish, PB | 1 |
| Weng, CC | 1 |
| Matin, A | 1 |
| Meistrich, ML | 1 |
| Grzesiak, M | 1 |
| Place, NJ | 1 |
| Holekamp, KE | 1 |
| Sisk, CL | 1 |
| Weldele, ML | 1 |
| Coscia, EM | 1 |
| Drea, CM | 1 |
| Glickman, SE | 1 |
| Omezzine, A | 1 |
| Chater, S | 2 |
| Mauduit, C | 4 |
| Florin, A | 3 |
| Tabone, E | 3 |
| Chuzel, F | 3 |
| Bars, R | 3 |
| Benahmed, M | 4 |
| Herman, RA | 3 |
| Measday, MA | 1 |
| Wallen, K | 7 |
| Goddard, I | 1 |
| Contard, P | 1 |
| Casto, JM | 1 |
| Ward, OB | 1 |
| Bartke, A | 1 |
| Miyata, K | 1 |
| Yabushita, S | 1 |
| Sano, M | 1 |
| Miyashita, K | 1 |
| Okuno, Y | 1 |
| Matsuo, M | 1 |
| Källén, B | 1 |
| Lu, SY | 1 |
| Liao, JW | 1 |
| Kuo, ML | 1 |
| Wang, SC | 1 |
| Hwang, JS | 1 |
| Ueng, TH | 1 |
| Bozec, A | 2 |
| Paulin, C | 1 |
| Wewers, D | 1 |
| Kaiser, S | 1 |
| Sachser, N | 1 |
| Yamasaki, K | 1 |
| Noda, S | 1 |
| Muroi, T | 1 |
| Mitoma, H | 1 |
| Takakura, S | 1 |
| Sakamoto, S | 1 |
| Goto, K | 2 |
| Koizumi, K | 2 |
| Takaori, H | 1 |
| Fujii, Y | 2 |
| Furuyama, Y | 1 |
| Saika, O | 2 |
| Suzuki, H | 2 |
| Saito, K | 2 |
| Suzuki, K | 2 |
| Ng, SL | 1 |
| Bidarkar, SS | 1 |
| Sourial, M | 1 |
| Farmer, PJ | 1 |
| Donath, S | 1 |
| Hutson, JM | 2 |
| Foster, PM | 3 |
| Harris, MW | 1 |
| Domínguez-Salazar, E | 2 |
| Camacho, FJ | 1 |
| Paredes, RG | 2 |
| Zehr, JL | 1 |
| Ohta, Y | 1 |
| Hashi, M | 1 |
| Ohbo, N | 1 |
| Tomaszycki, ML | 2 |
| Gouzoules, H | 2 |
| Li, Y | 2 |
| Zhang, H | 2 |
| Wang, WD | 1 |
| Liang, Y | 2 |
| Wu, DS | 2 |
| McFadden, D | 1 |
| Pasanen, EG | 1 |
| Raper, J | 1 |
| Lange, HS | 1 |
| Saunders, PT | 1 |
| Marchetti, NI | 1 |
| Mahood, IK | 1 |
| Hallmark, N | 1 |
| De Gendt, K | 1 |
| Verhoeven, G | 1 |
| O'Shaughnessy, P | 1 |
| Benbrahim-Tallaa, L | 1 |
| Siddeek, B | 1 |
| Tronchon, V | 1 |
| Friry, C | 1 |
| Shono, T | 2 |
| Lephart, ED | 3 |
| Husmann, DA | 2 |
| Silversides, DW | 1 |
| Price, CA | 1 |
| Cooke, GM | 1 |
| Tarasenko, LV | 1 |
| Sinitsyn, PV | 1 |
| Reznikov, AG | 1 |
| You, L | 2 |
| Casanova, M | 1 |
| Archibeque-Engle, S | 1 |
| Sar, M | 2 |
| Fan, LQ | 1 |
| Heck, HA | 1 |
| McCormick, CM | 1 |
| Mahoney, E | 1 |
| Axelson, JF | 1 |
| Smith, M | 1 |
| Duarte, M | 1 |
| Brenneman, KA | 1 |
| Heck, H | 1 |
| Lund, TD | 2 |
| Salyer, DL | 1 |
| Fleming, DE | 1 |
| McIntyre, BS | 1 |
| Barlow, NJ | 1 |
| Wallace, DG | 1 |
| Maness, SC | 1 |
| Gaido, KW | 2 |
| Zakaria, O | 1 |
| Imajima, T | 1 |
| Suita, S | 1 |
| Davis, JE | 1 |
| Shultz, VD | 1 |
| Phillips, S | 1 |
| Portillo, W | 1 |
| Baum, MJ | 2 |
| Bakker, J | 1 |
| McPhaul, MJ | 1 |
| van der Schoot, P | 1 |
| Thornton, JE | 1 |
| Irving, S | 1 |
| Goy, RW | 1 |
| Brand, T | 2 |
| Slob, AK | 2 |
| Melvin, JE | 1 |
| Hamill, RW | 1 |
| Sayag, N | 1 |
| Snapir, N | 1 |
| Robinzon, B | 1 |
| Arnon, E | 1 |
| el Halawani, ME | 1 |
| Grimm, VE | 1 |
| Tate-Ostroff, BA | 1 |
| Bridges, RS | 1 |
| Tobet, SA | 1 |
| Dohanich, GP | 1 |
| Witcher, JA | 1 |
| Clemens, LG | 1 |
2 reviews available for flutamide and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Permitted Daily Exposure of the Androgen Receptor Antagonist Flutamide.
Topics: Administration, Oral; Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug; | 2017 |
Hormonal influences on sexually differentiated behavior in nonhuman primates.
Topics: Androgen Antagonists; Androgens; Animals; Behavior, Animal; Female; Flutamide; Genitalia, Female; Ho | 2005 |
2 trials available for flutamide and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Morphological and functional alterations in adult boar epididymis: Effects of prenatal and postnatal administration of flutamide.
Topics: Androgen Antagonists; Animals; Connexin 43; Drug Administration Schedule; Epididymis; Female; Flutam | 2011 |
Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Aromatase; beta Catenin; Estradiol; Female; Flutami | 2012 |
75 other studies available for flutamide and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring.
Topics: Animals; Animals, Newborn; Cryptorchidism; Dienestrol; Dose-Response Relationship, Drug; Endpoint De | 2020 |
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part II: Endocrine-related gene expression assessment on male offspring rat testes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dienestrol; Female; Flutamide; Gene Expression Regulation; | 2020 |
Flutamide induces uterus and ovary damage in the mouse via apoptosis and excessive autophagy of cells following triggering of the unfolded protein response.
Topics: Androgen Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Relate | 2021 |
Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way.
Topics: Alcohol Drinking; Androgen Receptor Antagonists; Androgens; Animals; Brain-Derived Neurotrophic Fact | 2018 |
Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats.
Topics: Animals; Dose-Response Relationship, Drug; Estrous Cycle; Female; Flutamide; Imidazoles; Male; Nippl | 2017 |
Prenatal androgen-receptor activity has organizational morphological effects in mice.
Topics: Animals; Body Size; Dihydrotestosterone; Extremities; Female; Flutamide; Functional Laterality; Gona | 2017 |
[Effect of flutamide exposed during pregnancy on reproductive organs development and oxidative stress responsein in male mice offspring].
Topics: Animals; Female; Flutamide; Genitalia, Male; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Oxidativ | 2018 |
Identification of gene expression changes in postnatal rat foreskin after in utero anti-androgen exposure.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Female; Flutamide; Foreskin; Gene Expression Regul | 2014 |
Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.
Topics: Androgen Antagonists; Androgens; Animals; Biomarkers; Cohort Studies; Estrogens; Female; Flutamide; | 2015 |
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.
Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring.
Topics: Androgen Antagonists; Angiotensin II; Animals; Female; Flutamide; Mesenteric Arteries; Pregnancy; Pr | 2015 |
Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep.
Topics: Androgen Antagonists; Androgens; Animals; Estrous Cycle; Female; Fetal Development; Flutamide; Hypog | 2015 |
Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep.
Topics: Adiposity; Animals; Disease Models, Animal; Embryonic Development; Female; Flutamide; Insulin Resist | 2016 |
Manipulation of pre and postnatal androgen environments and anogenital distance in rats.
Topics: Androgen Antagonists; Androgens; Animals; Diethylhexyl Phthalate; Disease Models, Animal; Dose-Respo | 2016 |
Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS.
Topics: Androgen Antagonists; Androgens; Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; F | 2016 |
Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Dose-Response Relationship, Drug; Female; Flutamide; Ma | 2008 |
Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations.
Topics: Androgen Antagonists; Animals; Base Sequence; Bridged Bicyclo Compounds; DNA Methylation; Female; Fl | 2009 |
Androgen action in the masculinization programming window and development of male reproductive organs.
Topics: Androgen Antagonists; Androgens; Animals; Animals, Newborn; Dibutyl Phthalate; Female; Flutamide; Ge | 2010 |
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.
Topics: Animals; Dibutyl Phthalate; Female; Fetus; Flutamide; Immunohistochemistry; Male; Organ Size; Pregna | 2010 |
Immunohistochemical studies on the proliferative marker Ki-67 and estrogen receptor alpha (ERα) in the uterus of neonatal and immature pigs following exposure to flutamide.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Biomarkers; Cell Proliferation; Connective Tissue; | 2011 |
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
Copulatory efficiency and fertility in male rats exposed perinatally to flutamide.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Copulation; Female; Fertility; Flutamide; Genitalia | 2011 |
Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin 43 gene expression in adult porcine ovary.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Animals, Newborn; Connexin 43; Corpu | 2011 |
Prenatal and neonatal exposure to flutamide affects function of Leydig cells in adult boar.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Size; Estradiol; Female; Flutamide; Follicle S | 2012 |
Fetal radiation exposure induces testicular cancer in genetically susceptible mice.
Topics: Androgen Antagonists; Animals; Diethylstilbestrol; Estrogens, Non-Steroidal; Female; Fetus; Flutamid | 2012 |
Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocuta.
Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Carnivora; Chorionic Gonadotropin; Female; Fi | 2002 |
Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide.
Topics: Age Factors; Androgen Antagonists; Animals; Apoptosis; Caspase 3; Caspase 6; Caspases; Female; Fluta | 2003 |
Sex differences in interest in infants in juvenile rhesus monkeys: relationship to prenatal androgen.
Topics: Age Factors; Analysis of Variance; Androgen Antagonists; Animals; Behavior, Animal; Female; Flutamid | 2003 |
Alteration of lactate production and transport in the adult rat testis exposed in utero to flutamide.
Topics: Androgen Antagonists; Animals; Biological Transport; Female; Flutamide; Isoenzymes; L-Lactate Dehydr | 2003 |
Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide.
Topics: Androgen Antagonists; Animals; Copulation; Female; Flutamide; Genitalia, Male; Male; Play and Playth | 2003 |
Effects of perinatal exposure to flutamide on sex hormone responsiveness in F1 male rats.
Topics: Androgen Antagonists; Androgens; Animals; Biological Assay; Female; Flutamide; Follicle Stimulating | 2003 |
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna | 2004 |
Endocrine-disrupting activity in carbendazim-induced reproductive and developmental toxicity in rats.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Benomyl; Benzimidazoles; Carbamates; Dos | 2004 |
The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens.
Topics: Androgen Antagonists; Animals; Apoptosis; Dose-Response Relationship, Drug; Embryonic Development; F | 2004 |
Application of an antiandrogen during pregnancy infantilizes the male offsprings' behaviour.
Topics: Age Factors; Agonistic Behavior; Androgen Antagonists; Animals; Behavior, Animal; Female; Flutamide; | 2005 |
Effects of in utero and lactational exposure to flutamide in SD rats: comparison of the effects of administration periods.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Fl | 2005 |
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation | 2004 |
Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Calcitonin Gene-Re | 2005 |
Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages.
Topics: Androgen Antagonists; Androgens; Animals; Cryptorchidism; Epididymis; Female; Flutamide; Genitalia, | 2005 |
Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Conditioning, Psychological; Estrus; F | 2005 |
Prenatal androgen blockade accelerates pubertal development in male rhesus monkeys.
Topics: Androgen Antagonists; Animals; Female; Flutamide; Gonadotropin-Releasing Hormone; Hierarchy, Social; | 2006 |
Evaluation of general behavior, memory, learning performance, and brain sexual differentiation in F1 offspring males of rats treated with flutamide during late gestation.
Topics: Androgen Antagonists; Animals; Avoidance Learning; Behavior, Animal; Castration; Dose-Response Relat | 2005 |
Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: life history differences and effects of prenatal androgens.
Topics: Agonistic Behavior; Androgen Antagonists; Animals; Discriminant Analysis; Female; Flutamide; Macaca | 2005 |
[Impact of flutamide on sex differentiation in rats].
Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Hypospadias; Male; Pregnancy; Pren | 2006 |
Sex differences in otoacoustic emissions measured in rhesus monkeys (Macaca mulatta).
Topics: Androgen Antagonists; Androgens; Animal Communication; Animals; Cochlea; Data Interpretation, Statis | 2006 |
Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide.
Topics: Androgen Antagonists; Androgens; Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell P | 2006 |
[The effects of flutamide on the full gene expression of early testis development of embryonic period male SD].
Topics: Androgen Antagonists; Animals; Female; Flutamide; Gene Expression Profiling; Gene Expression Regulat | 2006 |
Role of androgens in fetal testis development and dysgenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androgen Antagonists; Animals; Body Weight; Carcinogens; Dibutyl P | 2007 |
Cognitive performance in rhesus monkeys varies by sex and prenatal androgen exposure.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Discrimination Learning; Female; Flu | 2007 |
Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.
Topics: Androgen Antagonists; Animals; Apoptosis; Cells, Cultured; Coculture Techniques; Down-Regulation; Fe | 2008 |
Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats.
Topics: Animals; Capsaicin; Cryptorchidism; Female; Flutamide; Male; Pregnancy; Prenatal Exposure Delayed Ef | 1994 |
Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; Animals, Newborn; Brain Chemistry; Cytoch | 1993 |
Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice.
Topics: Androgen Antagonists; Androgens; Animals; Epididymis; Female; Flutamide; Genitalia, Male; Gestationa | 1995 |
[The effect of prenatal stress on the development of hypophyseal gonadotropic function in male rats].
Topics: Androgen Antagonists; Androstatrienes; Animals; Aromatase; Aromatase Inhibitors; Cholestenone 5 alph | 1996 |
Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE.
Topics: Animals; Animals, Suckling; Brain; Dichlorodiphenyl Dichloroethylene; Female; Flutamide; Genitalia, | 1998 |
Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats.
Topics: Age Factors; Anal Canal; Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Corticosteron | 1999 |
Prenatal flutamide treatment eliminates the adult male rat's dependency upon vasopressin when forming social-olfactory memories.
Topics: Androgen Antagonists; Animals; Cognition; Female; Flutamide; Male; Memory; Pregnancy; Prenatal Expos | 1999 |
In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation.
Topics: Adipose Tissue; Administration, Oral; Androgen Antagonists; Animals; Blotting, Northern; Clusterin; | 1999 |
Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Animals, Newborn; Female; Flutamide; H | 2000 |
Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat.
Topics: Androgens; Animals; Animals, Newborn; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; | 2000 |
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Disease Models, Animal; Female; Fertility; Flutamide; | 2000 |
Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens.
Topics: Androgen Antagonists; Androgens; Animals; Anxiety, Separation; Female; Flutamide; Macaca mulatta; Ma | 2001 |
Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate.
Topics: Androgen Antagonists; Animals; Clusterin; Dibutyl Phthalate; Female; Fetus; Flutamide; Gene Expressi | 2001 |
Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory.
Topics: Androgen Antagonists; Animals; Behavior, Animal; Cues; Estrogens, Non-Steroidal; Female; Flutamide; | 2001 |
Effect of prenatal androgen receptor antagonist or aromatase inhibitor on sexual behavior, partner preference and neuronal Fos responses to estrous female odors in the rat accessory olfactory system.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androstatrienes; Animals; Aromatase Inhibitors; | 2002 |
Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens.
Topics: Androgens; Animals; Atrophy; Cryptorchidism; Drug Combinations; Female; Flutamide; Gestational Age; | 1992 |
Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide.
Topics: Androgen-Insensitivity Syndrome; Animals; Body Weight; Chi-Square Distribution; Cryptorchidism; Epid | 1992 |
Effects of prenatal antiandrogen treatment on masculinization and defeminization of guinea pigs.
Topics: Androgen Antagonists; Animals; Estradiol; Female; Flutamide; Guinea Pigs; In Vitro Techniques; Male; | 1991 |
Perinatal flutamide and mounting and lordosis behavior in adult female Wistar and Sprague-Dawley rats.
Topics: Animals; Animals, Newborn; Estrus; Female; Fetus; Flutamide; Hysterectomy; Male; Pregnancy; Prenatal | 1991 |
On the organization of partner preference behavior in female Wistar rats.
Topics: Androgen Antagonists; Animals; Copulation; Dihydrotestosterone; Dose-Response Relationship, Drug; Es | 1991 |
Hypogastric ganglion perinatal development: evidence for androgen specificity via androgen receptors.
Topics: Adrenergic Fibers; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Flutamide; Hypo | 1989 |
Embryonic sex steroids affect mating behavior and plasma LH in adult chickens.
Topics: Androstatrienes; Animals; Chickens; Estradiol; Female; Flutamide; Gonadal Steroid Hormones; Luteiniz | 1989 |
Nipple development and pup-induced prolactin release in male rats treated prenatally with the antiandrogen flutamide.
Topics: Anilides; Animals; Breast; Estradiol; Female; Flutamide; Lactation; Male; Maternal Behavior; Nipples | 1988 |
Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes.
Topics: Androstatrienes; Anilides; Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Estradio | 1986 |
Prenatal antiandrogen feminizes behavioral but not neurochemical response to estrogen.
Topics: Androgen Antagonists; Animals; Brain Chemistry; Estradiol; Estrogens; Female; Flutamide; Male; Ovari | 1985 |