Page last updated: 2024-10-27

flutamide and Cholestasis

flutamide has been researched along with Cholestasis in 5 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).

Research Excerpts

ExcerptRelevanceReference
"Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market."1.46Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. ( Honda, H; Ito, Y; Kawamoto, T; Morita, O, 2017)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dawson, S1
Stahl, S1
Paul, N1
Barber, J1
Kenna, JG1
Kawamoto, T1
Ito, Y1
Morita, O1
Honda, H1
Prattichizzo, FA1
Lee, HW1
Chung, JP1
Lee, KS2
Kim, KC1
Chon, CY1
Park, IS1
Kim, HG1
Hart, W1
Stricker, BH1

Other Studies

5 other studies available for flutamide and Cholestasis

ArticleYear
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:4

    Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; D

2017
Acute cholestatic hepatitis secondary to flutamide therapy.
    The American journal of medicine, 1994, Volume: 96, Issue:4

    Topics: Acute Disease; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Flutami

1994
A case of flutamide-induced acute cholestatic hepatitis--a case report.
    Yonsei medical journal, 1996, Volume: 37, Issue:3

    Topics: Acute Disease; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cholestasis; Flut

1996
Flutamide and hepatitis.
    Annals of internal medicine, 1989, Jun-01, Volume: 110, Issue:11

    Topics: Aged; Anilides; Chemical and Drug Induced Liver Injury; Cholestasis; Flutamide; Humans; Male

1989