flutamide has been researched along with Chemical and Drug Induced Liver Injury in 89 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term effects and tolerability of flutamide (Flu) in women with acne and seborrhea were evaluated." | 7.77 | Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011) |
| "Flutamide is an effective drug in treatment of hirsutism." | 7.75 | The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. ( Akcali, C; Balat, O; Cicek, H; Dikensoy, E; Pence, S, 2009) |
| "We describe the case of a 26-year-old girl with amenorrhea and severe hirsutism who was treated with flutamide 250 mg/day and developed liver toxicity during therapy." | 7.75 | Hepatotoxicity during low-dose flutamide treatment for hirsutism. ( Castelo-Branco, C; Del Pino, M, 2009) |
| "Flutamide is an antiandrogen and frequently used for the treatment of prostatic cancer." | 6.42 | [Toxic hepatitis and liver failure under therapy with flutamide]. ( Haupt, R; Lübbert, C; Ruf, BR; Wiese, M, 2004) |
| "In a recent study by the Casodex Combination Study Group, USA, patients in a flutamide (750 mg/day) plus LH-RH agonist group showed a high treatment failure rate, mainly due to flutamide-induced diarrhea and hepatotoxicity." | 5.08 | Recommended dose of flutamide with LH-RH agonist therapy in patients with advanced prostate cancer. ( Akaza, H; Aso, Y; Isaka, S; Kanetake, H; Koiso, K; Kotake, T; Usami, M, 1996) |
| "The long-term effects and tolerability of flutamide (Flu) in women with acne and seborrhea were evaluated." | 3.77 | Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011) |
| "Flutamide is an effective drug in treatment of hirsutism." | 3.75 | The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. ( Akcali, C; Balat, O; Cicek, H; Dikensoy, E; Pence, S, 2009) |
| "We describe the case of a 26-year-old girl with amenorrhea and severe hirsutism who was treated with flutamide 250 mg/day and developed liver toxicity during therapy." | 3.75 | Hepatotoxicity during low-dose flutamide treatment for hirsutism. ( Castelo-Branco, C; Del Pino, M, 2009) |
| "Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer, causes a temporary increase in transaminase and in some cases severe liver dysfunction." | 3.73 | Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice. ( Doi, M; Goda, R; Ichimura, E; Matsuzaki, Y; Nagai, D; Nishikawa, K; Tomura, A, 2006) |
| "To prevent treatment withdrawal due to flutamide-induced liver dysfunction, we performed maximum androgen blockade (MAB) therapy by combining a luteinizing hormone-releasing hormone agonist or orchiectomy with low-dose flutamide (125 mg x 2/day) in patients with prostate cancer." | 3.71 | [Clinical efficacy of treatment with low-dose flutamide in maximum androgen blockade therapy]. ( Fujii, T; Hosomi, M; Kiyohara, H; Nakayama, J; Shimizu, K, 2001) |
| " In 8 male patients, mean age 75 years (range 65-83), flutamide was indicated for palliative therapy of disseminated prostatic carcinoma, and in one young female (14 years) was given for the treatment of facial hirsutism." | 3.71 | Flutamide-induced hepatotoxicity: report of a case series. ( Alcántara, R; Andrade, RJ; Camargo, R; Fernández, MC; Ferrer, T; Fraga, E; García Cortés, M; García-Ruiz, E; Lucena, MI; Martín-Vivaldi, R; Montero, JL; Peláez, G; Pizarro, MA; Romero-Gómez, M; Rosemary-Gómez, M; Sánchez Martínez, H; Suárez, F, 2001) |
| "We describe a 76-year-old male patient who developed a life-threatening acute hepatotoxicity possibly caused by flutamide, an antiandrogen drug given during the previous 10 months, in the scenario of a brief moderate hypotension secondary to atrial flutter." | 3.69 | [Hepatoxicity caused by flutamide increased by hypotensive situation?]. ( Fedriani Gorria, J; García López, F; Serrano Hernández, N, 1996) |
| "Flutamide (FLU) is a non-steroidal antiandrogen drug approved for the treatment of advanced prostate cancer." | 2.55 | Flutamide-induced hepatotoxicity: ethical and scientific issues. ( Borgia, L; di Muzio, M; Giorgetti, A; Giorgetti, R; Girolami, D; Tagliabracci, A, 2017) |
| "Flutamide is an antiandrogen and frequently used for the treatment of prostatic cancer." | 2.42 | [Toxic hepatitis and liver failure under therapy with flutamide]. ( Haupt, R; Lübbert, C; Ruf, BR; Wiese, M, 2004) |
| " Strikingly, about a two-fold increase of the FLU-NAC conjugate was detected when treated with both FLU and XLGB, indicating an elevated amount of toxic metabolite produced from FLU in the present of XLGB." | 1.62 | Potentiation of flutamide-induced hepatotoxicity in mice by Xian-Ling-Gu-Bao through induction of CYP1A2. ( Ding, Y; Li, Y; Lu, Y; Ma, H; Shi, F; Xu, Y; Yang, F, 2021) |
| "The anti-prostate cancer drug flutamide occasionally causes hepatotoxicity, and predictive biomarkers of flutamide-induced liver injury (FILI) are needed to improve safety of this drug." | 1.42 | Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury. ( Ando, H; Fujimura, A; Hosohata, K; Inui, K; Kurokawa, S; Masuda, S; Matsubara, K; Morita, T; Nakano, K; Takada, M; Tateishi, M; Ushijima, K; Yonezawa, A, 2015) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Liver disorders were the most common adverse reactions associated with flutamide and bicalutamide, but not with cyproterone acetate." | 1.33 | Spontaneous reporting of hepatotoxicity associated with antiandrogens: data from the Spanish pharmacovigilance system. ( Hidalgo, A; Manso, G; Revuelta, P; Salgueiro, E; Thole, Z, 2006) |
| "Flutamide was stopped and patient made slow recovery." | 1.32 | Flutamide-induced hepatotoxicity with possible potentiation by simvastatin. ( Ashar, U; Bhaduri, A; Desai, D, 2003) |
| "The flutamide therapy was immediately discontinued and this resulted in spontaneous remission (clinical and liver function test results returned to normal) during the next 8 weeks." | 1.31 | Flutamide-induced acute hepatitis in advanced prostate cancer patients. ( Kraus, I; Oguic, R; Vitezic, D, 2001) |
| "Flutamide is a non-steroidal anti-androgen used in the treatment of prostate cancer, usually in combination with LHRH-analogs." | 1.30 | [Liver failure caused by flutamide]. ( Ferrero Doria, R; Fontana Compiano, LO; Gil Franco, J; Guzmán Martínez-Valls, PL; Morga Egea, JP; Rico Galiano, JL; Sempere Gutiérrez, A; Tomás Ros, M, 1997) |
| "Flutamide is a nonsteroidal antiandrogen drug used in the treatment of prostatic cancer." | 1.30 | Flutamide-induced acute hepatitis: investigation on the role of immunoallergic mechanisms. ( Albano, E; Boldorini, R; Morelli, S; Pittau, S; Pontiroli, L; Sartori, M, 1998) |
| "The pharmacokinetic parameters of Flu were as follows: in normal rats, K = 0." | 1.30 | Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats. ( Li, D; Xu, CJ, 1998) |
| "We retrospectively reviewed 121 prostate cancer patients who received long-term antiandrogen, either flutamide (n = 56) or cyproterone acetate (n = 65), and had normal pretreatment serum alanine aminotransferase (ALT) levels." | 1.30 | Antiandrogen hepatotoxicity in patients with chronic viral hepatitis. ( Chen, J; Kao, JH; Lai, MK; Liu, CM; Pu, YS, 1999) |
| "Flutamide is a potent hepatotoxin in certain patients." | 1.29 | Flutamide hepatotoxicity. ( Fourcroy, JL; Wysowski, DK, 1996) |
| "Flutamide appears to cause hepatotoxic effects in certain patients." | 1.29 | Fatal and nonfatal hepatotoxicity associated with flutamide. ( Freiman, JP; Horton, ML; Tourtelot, JB; Wysowski, DK, 1993) |
| "Flutamide toxicity was common." | 1.29 | Flutamide-associated liver toxicity during treatment with total androgen suppression and radiation therapy for prostate cancer. ( Andras, EJ; Brooks, CP; Chang, GC; Gilbert, RM; Leibenhaut, MH; Linstadt, DE; Rosenthal, SA; Stickney, DR; Wolkov, HB, 1996) |
| "Flutamide is a nonsteroidal antiandrogen commonly used in the treatment of prostate cancer." | 1.29 | Flutamide-induced toxic hepatitis. Potential utility of ursodeoxycholic acid administration in toxic hepatitis. ( Barbara, L; Cicognani, C; Malavolti, M; Morselli-Labate, AM; Sama, C, 1996) |
| "A 66-year-old man with metastatic prostate cancer was treated with bilateral orchiectomy and 750 mg." | 1.28 | Near fatal liver dysfunction secondary to administration of flutamide for prostate cancer. ( Dankoff, JS, 1992) |
| "A case of severe toxic hepatitis in a patient with metastatic prostatic cancer treated for three months with flutamide (Eulexin) combined with an LHRH analogue, goserelin (Zoladex) is described." | 1.28 | [Severe toxic hepatitis during flutamide (Eulexin) treatment]. ( Iversen, P; Møller, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.25) | 18.7374 |
| 1990's | 36 (40.45) | 18.2507 |
| 2000's | 28 (31.46) | 29.6817 |
| 2010's | 21 (23.60) | 24.3611 |
| 2020's | 2 (2.25) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Ball, AL | 1 |
| Jolly, CE | 1 |
| Lennon, MG | 1 |
| Lyon, JJ | 1 |
| Alfirevic, A | 1 |
| Chadwick, AE | 1 |
| Ding, Y | 1 |
| Ma, H | 1 |
| Xu, Y | 1 |
| Yang, F | 1 |
| Li, Y | 1 |
| Shi, F | 1 |
| Lu, Y | 1 |
| Giorgetti, R | 1 |
| di Muzio, M | 1 |
| Giorgetti, A | 1 |
| Girolami, D | 1 |
| Borgia, L | 1 |
| Tagliabracci, A | 1 |
| Ogihara, T | 1 |
| Arakawa, H | 1 |
| Jomura, T | 1 |
| Idota, Y | 1 |
| Koyama, S | 1 |
| Yano, K | 1 |
| Kojima, H | 1 |
| Goda, K | 1 |
| Muta, K | 1 |
| Yasui, Y | 1 |
| Oshida, S | 1 |
| Kitatani, K | 1 |
| Takekoshi, S | 1 |
| Mattes, W | 1 |
| Davis, K | 1 |
| Fabian, E | 1 |
| Greenhaw, J | 1 |
| Herold, M | 1 |
| Looser, R | 1 |
| Mellert, W | 1 |
| Groeters, S | 1 |
| Marxfeld, H | 1 |
| Moeller, N | 1 |
| Montoya-Parra, G | 1 |
| Prokoudine, A | 1 |
| van Ravenzwaay, B | 1 |
| Strauss, V | 1 |
| Walk, T | 1 |
| Kamp, H | 1 |
| Nakano, K | 1 |
| Ando, H | 1 |
| Kurokawa, S | 1 |
| Hosohata, K | 1 |
| Ushijima, K | 1 |
| Takada, M | 1 |
| Tateishi, M | 1 |
| Yonezawa, A | 1 |
| Masuda, S | 1 |
| Matsubara, K | 1 |
| Inui, K | 1 |
| Morita, T | 1 |
| Fujimura, A | 1 |
| Dikensoy, E | 1 |
| Balat, O | 1 |
| Pence, S | 1 |
| Akcali, C | 1 |
| Cicek, H | 1 |
| de Zegher, F | 1 |
| Ibáñez, L | 1 |
| Morita, M | 1 |
| Akai, S | 1 |
| Hosomi, H | 1 |
| Tsuneyama, K | 2 |
| Nakajima, M | 2 |
| Yokoi, T | 2 |
| Castelo-Branco, C | 1 |
| Del Pino, M | 1 |
| Paradisi, R | 1 |
| Fabbri, R | 1 |
| Porcu, E | 1 |
| Battaglia, C | 1 |
| Seracchioli, R | 1 |
| Venturoli, S | 1 |
| Higuchi, S | 1 |
| Kobayashi, M | 1 |
| Yano, A | 1 |
| Fukami, T | 1 |
| Bruni, V | 1 |
| Peruzzi, E | 1 |
| Dei, M | 1 |
| Nannini, S | 1 |
| Seravalli, V | 1 |
| Sisti, G | 1 |
| Fambrini, M | 1 |
| Karaahmet, F | 1 |
| Kurt, K | 1 |
| Ozono, S | 1 |
| Yamaguchi, A | 1 |
| Mochizuki, H | 1 |
| Kawakami, T | 1 |
| Fujimoto, K | 1 |
| Otani, T | 1 |
| Yoshida, K | 1 |
| Ichinei, M | 1 |
| Yamashita, T | 1 |
| Hirao, Y | 1 |
| Ashar, U | 1 |
| Desai, D | 1 |
| Bhaduri, A | 1 |
| Matsuzaki, Y | 2 |
| Nishikawa, K | 2 |
| Takashima, E | 1 |
| Iguchi, K | 1 |
| Usui, S | 1 |
| Yamamoto, H | 1 |
| Hirano, K | 1 |
| Lübbert, C | 1 |
| Wiese, M | 1 |
| Haupt, R | 1 |
| Ruf, BR | 1 |
| Lin, AD | 1 |
| Chen, KK | 1 |
| Lin, AT | 1 |
| Chang, YH | 1 |
| Wu, HH | 1 |
| Kuo, JY | 1 |
| Huang, WJ | 1 |
| Hsu, YS | 1 |
| Chung, HJ | 1 |
| Chang, LS | 1 |
| Manolakopoulos, S | 1 |
| Bethanis, S | 1 |
| Armonis, A | 1 |
| Economou, M | 1 |
| Avgerinos, A | 1 |
| Tzourmakliotis, D | 1 |
| Vázquez Romero, M | 1 |
| Gil Grande, L | 1 |
| López Serrano, P | 1 |
| Alemán Villanueva, S | 1 |
| García Plaza, A | 1 |
| Bengoechea Gallastegui, L | 1 |
| Vita Garay, A | 1 |
| Castiella Eguzkiza, A | 1 |
| Egido Arroyo, JF | 1 |
| Mannaa, F | 1 |
| Ahmed, HH | 1 |
| Estefan, SF | 1 |
| Sharaf, HA | 1 |
| Eskander, EF | 1 |
| Manso, G | 1 |
| Thole, Z | 1 |
| Salgueiro, E | 1 |
| Revuelta, P | 1 |
| Hidalgo, A | 1 |
| Osculati, A | 1 |
| Castiglioni, C | 1 |
| Nagai, D | 1 |
| Ichimura, E | 1 |
| Goda, R | 1 |
| Tomura, A | 1 |
| Doi, M | 1 |
| Boelsterli, UA | 1 |
| Ho, HK | 1 |
| Zhou, S | 2 |
| Leow, KY | 1 |
| Kang, P | 1 |
| Dalvie, D | 1 |
| Smith, E | 1 |
| Deese, A | 1 |
| Miquel, M | 1 |
| Soler, A | 1 |
| Vaqué, A | 1 |
| Ojanguren, I | 1 |
| Costa, J | 1 |
| Planas, R | 1 |
| Wysowski, DK | 3 |
| Fourcroy, JL | 2 |
| Freiman, JP | 1 |
| Tourtelot, JB | 1 |
| Horton, ML | 1 |
| Dourakis, SP | 1 |
| Alexopoulou, AA | 1 |
| Hadziyannis, SJ | 1 |
| Wallace, C | 1 |
| Lalor, EA | 1 |
| Chik, CL | 1 |
| Martínez Bruna, MS | 1 |
| Velila Alcubilla, JP | 1 |
| Abinzano, M | 1 |
| Martínez Velasco, C | 1 |
| García Mauriz, ME | 1 |
| Urbieta Echezareta, M | 1 |
| Prattichizzo, FA | 1 |
| Caballería, E | 1 |
| Aragó, JV | 1 |
| Sanchís, A | 1 |
| Koning, RP | 1 |
| Rosman, AS | 1 |
| Frissora-Rodeo, C | 1 |
| Marshall, AT | 1 |
| Reiter, BP | 1 |
| Paronetto, F | 1 |
| Rosenthal, SA | 1 |
| Linstadt, DE | 1 |
| Leibenhaut, MH | 1 |
| Andras, EJ | 1 |
| Brooks, CP | 1 |
| Stickney, DR | 1 |
| Chang, GC | 1 |
| Wolkov, HB | 1 |
| Gilbert, RM | 1 |
| Andréjak, M | 1 |
| Nguyen-Khac, E | 1 |
| Decocq, G | 1 |
| Capron, JP | 1 |
| Lee, HW | 1 |
| Chung, JP | 1 |
| Lee, KS | 2 |
| Kim, KC | 1 |
| Chon, CY | 1 |
| Park, IS | 1 |
| Kim, HG | 1 |
| Cicognani, C | 1 |
| Malavolti, M | 1 |
| Morselli-Labate, AM | 1 |
| Sama, C | 1 |
| Barbara, L | 1 |
| Serrano Hernández, N | 1 |
| García López, F | 1 |
| Fedriani Gorria, J | 1 |
| Akaza, H | 1 |
| Isaka, S | 1 |
| Usami, M | 1 |
| Kanetake, H | 1 |
| Kotake, T | 1 |
| Koiso, K | 1 |
| Aso, Y | 1 |
| Satoh, T | 1 |
| Egawa, S | 1 |
| Katsuta, M | 1 |
| Iwamura, M | 1 |
| Uchida, T | 1 |
| Koshiba, K | 1 |
| Guzmán Martínez-Valls, PL | 1 |
| Ferrero Doria, R | 1 |
| Morga Egea, JP | 1 |
| Tomás Ros, M | 1 |
| Rico Galiano, JL | 1 |
| Sempere Gutiérrez, A | 1 |
| Gil Franco, J | 1 |
| Fontana Compiano, LO | 1 |
| Wietzke, P | 1 |
| Münke, H | 1 |
| Hartmann, H | 1 |
| Ramadori, G | 1 |
| Cantalejo Moreira, M | 1 |
| García Espinosa, V | 1 |
| Martín Gutiérrez, JC | 1 |
| García Puig, J | 1 |
| García-Gascó, P | 1 |
| Morata Aldea, C | 1 |
| Segura Huertas, A | 1 |
| Aparicio Urtasun, J | 1 |
| Mena, FJ | 1 |
| Goyeneche, ML | 1 |
| Velicia, R | 1 |
| González, JM | 1 |
| Bellido, J | 1 |
| Caro-Patón, A | 1 |
| Pogromov, AP | 1 |
| Popova, AM | 1 |
| Pontiroli, L | 1 |
| Sartori, M | 1 |
| Pittau, S | 1 |
| Morelli, S | 1 |
| Boldorini, R | 1 |
| Albano, E | 1 |
| Cuevas Campos, MA | 1 |
| Pareja Llorens, G | 1 |
| García Romero, E | 1 |
| Bertomeu Blanch, F | 1 |
| Xu, CJ | 2 |
| Li, D | 2 |
| Nicolás, D | 1 |
| Pérez-EbrI, ML | 1 |
| Sarrión, JV | 1 |
| Nos, P | 1 |
| Pu, YS | 1 |
| Liu, CM | 1 |
| Kao, JH | 1 |
| Chen, J | 1 |
| Lai, MK | 1 |
| Wada, T | 2 |
| Ueda, M | 1 |
| Abe, K | 1 |
| Kobari, T | 1 |
| Yamazaki, H | 2 |
| Nakata, J | 1 |
| Ikemoto, I | 2 |
| Ohishi, Y | 2 |
| Aizawa, Y | 2 |
| Román Llorente, FJ | 1 |
| Alvarez Navascués, C | 1 |
| Suárez González, A | 1 |
| González Bernal, AC | 1 |
| Ruiz-Rebollo, M | 1 |
| Atienza-Sánchez, R | 1 |
| López-García, E | 1 |
| Shimizu, K | 1 |
| Kiyohara, H | 1 |
| Nakayama, J | 1 |
| Fujii, T | 1 |
| Hosomi, M | 1 |
| Kraus, I | 1 |
| Vitezic, D | 1 |
| Oguic, R | 1 |
| García Cortés, M | 1 |
| Andrade, RJ | 1 |
| Lucena, MI | 1 |
| Sánchez Martínez, H | 1 |
| Fernández, MC | 1 |
| Ferrer, T | 1 |
| Martín-Vivaldi, R | 1 |
| Peláez, G | 1 |
| Suárez, F | 1 |
| Romero-Gómez, M | 1 |
| Montero, JL | 1 |
| Fraga, E | 1 |
| Camargo, R | 1 |
| Alcántara, R | 1 |
| Pizarro, MA | 1 |
| García-Ruiz, E | 1 |
| Rosemary-Gómez, M | 1 |
| Ruiz, R | 1 |
| Casañ, R | 1 |
| Juan, O | 1 |
| Kojima, M | 1 |
| Kamoi, K | 1 |
| Ukimura, O | 1 |
| Fujito, A | 1 |
| Nakao, M | 1 |
| Tanaka, S | 1 |
| Miyashita, H | 1 |
| Iwamoto, N | 1 |
| Ohe, H | 1 |
| Kitamori, T | 1 |
| Date, S | 1 |
| Kitamura, K | 1 |
| Araki, H | 1 |
| Aoki, T | 1 |
| Imada, N | 1 |
| Takada, H | 1 |
| Imaide, Y | 1 |
| Mikami, K | 1 |
| Uchida, M | 1 |
| Saitoh, M | 1 |
| Miki, T | 1 |
| Gomez, JL | 1 |
| Dupont, A | 1 |
| Cusan, L | 1 |
| Tremblay, M | 1 |
| Suburu, R | 1 |
| Lemay, M | 1 |
| Labrie, F | 1 |
| Dankoff, JS | 1 |
| Alperine, M | 1 |
| Cohen, L | 1 |
| Cocheton, JJ | 1 |
| Lecomte, I | 1 |
| Meyniel, D | 1 |
| Corkery, JC | 1 |
| Bihrle, W | 1 |
| McCaffrey, JA | 1 |
| Whitcomb, FF | 1 |
| Levy, C | 1 |
| Ellis, R | 1 |
| Coppéré, H | 1 |
| Perraud, Y | 1 |
| Gérard, F | 1 |
| Jouffre, C | 1 |
| David, A | 1 |
| Barthélémy, C | 1 |
| Audigier, JC | 1 |
| Møller, S | 2 |
| Iversen, P | 2 |
| Franzmann, MB | 1 |
| Hart, W | 1 |
| Stricker, BH | 1 |
8 reviews available for flutamide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Flutamide-induced hepatotoxicity: ethical and scientific issues.
Topics: Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Humans; Male; Prosp | 2017 |
[Therapeutic options for drug induced liver injury: the efficacy of UDCA based on EBM].
Topics: Androgen Antagonists; Animals; Chemical and Drug Induced Liver Injury; Evidence-Based Medicine; Flut | 2003 |
[Toxic hepatitis and liver failure under therapy with flutamide].
Topics: Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Hormonal; Biopsy, Needle; Chemical and Drug I | 2004 |
Bioactivation and hepatotoxicity of nitroaromatic drugs.
Topics: Benzophenones; Biotransformation; Chemical and Drug Induced Liver Injury; Flutamide; Imidazolidines; | 2006 |
[Hepatotoxicity due to flutamide].
Topics: Aged; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Male; Prostatic Neoplasms | 1994 |
[The hepatotoxicity of flutamide].
Topics: Adenocarcinoma, Clear Cell; Aged; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents, Hormonal; Ch | 1998 |
[Acute flutamide-induced hepatitis].
Topics: Acute Disease; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Flutamide; Humans | 1999 |
2 trials available for flutamide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Caffeine test in predicting flutamide-induced hepatic injury in patients with prostate cancer.
Topics: Aged; Androgen Antagonists; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A | 2002 |
Recommended dose of flutamide with LH-RH agonist therapy in patients with advanced prostate cancer.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemical and Drug In | 1996 |
79 other studies available for flutamide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.
Topics: Chemical and Drug Induced Liver Injury; DNA, Mitochondrial; Flutamide; Genotype; Haplotypes; Humans; | 2023 |
Potentiation of flutamide-induced hepatotoxicity in mice by Xian-Ling-Gu-Bao through induction of CYP1A2.
Topics: Androgen Antagonists; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Drug | 2021 |
Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity.
Topics: Alanine Transaminase; Albumins; Aspartate Aminotransferases; Cells, Cultured; Chemical and Drug Indu | 2017 |
Selenium and Glutathione-Depleted Rats as a Sensitive Animal Model to Predict Drug-Induced Liver Injury in Humans.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flutamide; Glutathione; Mal | 2019 |
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma.
Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Dr | 2014 |
Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury.
Topics: Aged; Alanine Transaminase; Androgen Antagonists; Animals; Antineoplastic Agents; Chemical and Drug | 2015 |
The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism.
Topics: Adolescent; Adult; Alanine Transaminase; Androgen Antagonists; Aspartate Aminotransferases; Chemical | 2009 |
Low-dose flutamide for women with androgen excess: anti-androgenic efficacy and hepatic safety.
Topics: Androgen Antagonists; Androgens; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutis | 2009 |
Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.
Topics: Androgen Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Li | 2009 |
Hepatotoxicity during low-dose flutamide treatment for hirsutism.
Topics: Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; H | 2009 |
Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period.
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cont | 2011 |
Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.
Topics: Androgen Antagonists; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antineoplastic Agen | 2012 |
Hepatotoxicity with low- and ultralow-dose flutamide: a surveillance study on 203 hyperandrogenic young females.
Topics: Adolescent; Adult; Alanine Transaminase; Androgen Antagonists; Aspartate Aminotransferases; Biomarke | 2012 |
Hepatotoxicity with flutamide.
Topics: Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Humans; Hyperandrog | 2012 |
Flutamide-induced hepatotoxicity with possible potentiation by simvastatin.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Synergism; Flutamide; Humans; Male; Prostatic Neo | 2003 |
Metabolite profiles of flutamide in serum from patients with flutamide-induced hepatic dysfunction.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Liver Diseases; | 2003 |
Antiandrogen-associated hepatotoxicity in the management of advanced prostate cancer.
Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Chemical and | 2003 |
Toxic hepatitis after sequential administration of flutamide and cyproterone acetate.
Topics: Aged; Androgen Antagonists; Bilirubin; Chemical and Drug Induced Liver Injury; Cyproterone Acetate; | 2004 |
[Liver toxicity associated with flutamide].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Fl | 2004 |
[Toxic hepatitis after flutamide treatment].
Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Carrier State; Chemical and Drug Induce | 2005 |
Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats.
Topics: Androgen Antagonists; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Enzyme-Linked Immunos | 2005 |
Spontaneous reporting of hepatotoxicity associated with antiandrogens: data from the Spanish pharmacovigilance system.
Topics: Adverse Drug Reaction Reporting Systems; Androgen Antagonists; Anilides; Chemical and Drug Induced L | 2006 |
Fatal liver complications with flutamide.
Topics: Adolescent; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Flu | 2006 |
Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice.
Topics: Alanine Transaminase; Amino Acids; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; C | 2006 |
Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Aryl Hydrocarbon Hydroxylases; Biotransformat | 2007 |
Suspected cross-hepatotoxicity of flutamide and cyproterone acetate.
Topics: Acute Disease; Adenocarcinoma; Adrenal Cortex Hormones; Aged; Androgen Antagonists; Antineoplastic A | 2007 |
Flutamide hepatotoxicity.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combi | 1996 |
Fatal and nonfatal hepatotoxicity associated with flutamide.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antineoplastic Combined Chemothera | 1993 |
Safety of flutamide?
Topics: Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; Humans; Male | 1994 |
Fulminant hepatitis after flutamide treatment.
Topics: Acute Disease; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Flutamide; Humans; I | 1994 |
Hepatotoxicity complicating flutamide treatment of hirsutism.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; Humans | 1993 |
[Hepatotoxicity and flutamide].
Topics: Aged; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Male; Prostatic Neoplasms | 1993 |
Acute cholestatic hepatitis secondary to flutamide therapy.
Topics: Acute Disease; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Flutami | 1994 |
[Treatment of hirsutism].
Topics: Chemical and Drug Induced Liver Injury; Flutamide; Hirsutism; Humans; Risk Factors | 1994 |
Cholestatic hepatitis following flutamide.
Topics: Adenocarcinoma; Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Flutamide; | 1993 |
Flutamide-associated liver toxicity during treatment with total androgen suppression and radiation therapy for prostate cancer.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Androgen Antagonists; Antineoplastic Agents, Hormo | 1996 |
[Fulminant hepatitis caused by flutamide].
Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Fatal | 1996 |
A case of flutamide-induced acute cholestatic hepatitis--a case report.
Topics: Acute Disease; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cholestasis; Flut | 1996 |
Flutamide-induced toxic hepatitis. Potential utility of ursodeoxycholic acid administration in toxic hepatitis.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Ch | 1996 |
[Hepatoxicity caused by flutamide increased by hypotensive situation?].
Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; | 1996 |
[A case of fulminant hepatitis caused by antiandrogen, flutamide in a patient with prostate cancer].
Topics: Aged; Androgen Antagonists; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Flutamide; Human | 1997 |
[Liver failure caused by flutamide].
Topics: Acute Disease; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Live | 1997 |
[Hepatotoxicity of flutamide].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biopsy; Chemical and Drug Induced Liver In | 1997 |
[Hepatotoxicity from flutamide].
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Flutamide; Hu | 1997 |
[Fulminant hepatitis associated with treatment with flutamide].
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemical and Drug In | 1997 |
[Acute cholestatic hepatitis secondary to flutamide].
Topics: Acute Disease; Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cholestasis, Intr | 1998 |
Flutamide-induced acute hepatitis: investigation on the role of immunoallergic mechanisms.
Topics: Acute Disease; Aged; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Chemical and Dr | 1998 |
[Toxic hepatitis caused by flutamide].
Topics: Aged; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Ma | 1998 |
Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats.
Topics: Androgen Antagonists; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1998 |
Antiandrogen hepatotoxicity in patients with chronic viral hepatitis.
Topics: Aged; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cyproterone Acetate; Flutamide; | 1999 |
[Risk factor of liver disorders caused by flutamide--statistical analysis using multivariate logistic regression analysis].
Topics: Alanine Transaminase; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Flutamide; Human | 1999 |
Pharmacokinetics of 2-hydroxyflutamide, a major metabolite of flutamide, in normal and CCl4-poisoned rats.
Topics: Androgen Antagonists; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1999 |
[Changes in liver function induced by flutamide in patients with prostate cancer (studies in patients treated with total androgen blockage)].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Ch | 2000 |
[Toxic hepatitis caused by flutamide and hirsutism].
Topics: Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; H | 2000 |
[Hirsutism, flutamide and hepatotoxicity].
Topics: Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hirsutism; H | 2001 |
[Clinical efficacy of treatment with low-dose flutamide in maximum androgen blockade therapy].
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Drug Administ | 2001 |
Flutamide-induced acute hepatitis in advanced prostate cancer patients.
Topics: Adenocarcinoma; Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; C | 2001 |
Flutamide-induced hepatotoxicity: report of a case series.
Topics: Adolescent; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Live | 2001 |
[Hepatotoxicity due to flutamide].
Topics: Aged; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Ma | 2001 |
Clinical utility of ursodeoxycholic acid in preventing flutamide-induced hepatopathy in patients with prostate cancer: a preliminary study.
Topics: Aged; Antineoplastic Agents, Hormonal; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Li | 2002 |
Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alkaline Phosphatase; Androgen | 1992 |
Near fatal liver dysfunction secondary to administration of flutamide for prostate cancer.
Topics: Aged; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Male; Prostatic Neoplasms | 1992 |
[Acute hepatitis caused by flutamide].
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Flutamide; Humans | 1991 |
Flutamide-related fulminant hepatic failure.
Topics: Bone Neoplasms; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Male; Middle Aged; Prosta | 1991 |
[A case of acute hepatitis caused by flutamide].
Topics: Acute Disease; Anilides; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Male; Middle Age | 1990 |
Flutamide-induced liver failure.
Topics: Aged; Anilides; Chemical and Drug Induced Liver Injury; Flutamide; Humans; Liver; Liver Diseases; Ma | 1990 |
Flutamide and hepatitis.
Topics: Aged; Anilides; Chemical and Drug Induced Liver Injury; Cholestasis; Flutamide; Humans; Male | 1989 |
[Severe toxic hepatitis during flutamide (Eulexin) treatment].
Topics: Anilides; Ascites; Chemical and Drug Induced Liver Injury; Female; Flutamide; Hepatic Encephalopathy | 1989 |