flutamide has been researched along with Chemical and Drug Induced Liver Injury, Chronic in 2 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Chemical and Drug Induced Liver Injury, Chronic: Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flutamide is known to cause severe adverse events, which includes idiosyncratic liver injury." | 1.91 | Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes. ( Ijiri, Y; Kato, R; Kohda, Y; Noda, T; Tanaka, S; Yamada, T, 2023) |
| "Severe hepatotoxicity occurred in a prostate cancer patient treated with 375 mg of flutamide per day, 125 mg three times a day, for 11 weeks." | 1.30 | [Flutamide-induced hepatic disorder and serum concentrations of flutamide and its metabolites in patients with prostate cancer]. ( Koyama, M; Matsumoto, M; Nakagawa, Y, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, R | 1 |
| Yamada, T | 1 |
| Noda, T | 1 |
| Tanaka, S | 1 |
| Kohda, Y | 1 |
| Ijiri, Y | 1 |
| Nakagawa, Y | 1 |
| Koyama, M | 1 |
| Matsumoto, M | 1 |
2 other studies available for flutamide and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
Topics: Androgen Antagonists; Anilides; Chemical and Drug Induced Liver Injury, Chronic; Flutamide; Humans; | 2023 |
[Flutamide-induced hepatic disorder and serum concentrations of flutamide and its metabolites in patients with prostate cancer].
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Androgen Antagonists; Antineoplastic Agents, Hormonal | 1999 |