flutamide has been researched along with Cell Transformation, Neoplastic in 6 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a primary squamous cell carcinoma of the prostate that developed in a 57-year-old man, 3 years after treatment with leuprolide and flutamide for Stage D1 adenocarcinoma of the prostate." | 7.69 | Squamous cell carcinoma of the prostate: a transformation from adenocarcinoma after the use of a luteinizing hormone-releasing hormone agonist and flutamide. ( Braslis, KG; Civantos, F; Davi, RC; Nelson, E; Soloway, MS, 1995) |
| "We report a primary squamous cell carcinoma of the prostate that developed in a 57-year-old man, 3 years after treatment with leuprolide and flutamide for Stage D1 adenocarcinoma of the prostate." | 3.69 | Squamous cell carcinoma of the prostate: a transformation from adenocarcinoma after the use of a luteinizing hormone-releasing hormone agonist and flutamide. ( Braslis, KG; Civantos, F; Davi, RC; Nelson, E; Soloway, MS, 1995) |
| "Oxidative stress plays a role in prostate cancer (PrCa) initiation and development." | 1.37 | Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage. ( Boque, N; Calvo, A; Campion, J; Catena, R; Endermann, T; Gonzalez-Moreno, O; Milagro, F; Redrado, M; Saito, Y; Schomburg, L; Takahashi, K, 2011) |
| "Lethal prostate cancers often become androgen-independent due to androgen receptor (AR) overexpression." | 1.34 | Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells. ( Benbrahim-Tallaa, L; Liu, J; Waalkes, MP; Webber, MM, 2007) |
| "Lethal phenotypes of human prostate cancer are characterized by progression to androgen independence, although the mechanisms behind this progression remain unclear." | 1.33 | Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation. ( Benbrahim-Tallaa, L; Waalkes, MP; Webber, MM, 2005) |
| "Flutamide has also been shown to produce Leydig cell tumors within 1 year, presumably due to sustained hypersecretion of luteinizing hormone (LH) which occurs following disruption of the hypothalamic-pituitary-testicular (HPT) axis." | 1.29 | Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats. ( Biegel, LB; Cook, JC; Frame, SR; Mullin, LS, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonzalez-Moreno, O | 1 |
| Boque, N | 1 |
| Redrado, M | 1 |
| Milagro, F | 1 |
| Campion, J | 1 |
| Endermann, T | 1 |
| Takahashi, K | 1 |
| Saito, Y | 1 |
| Catena, R | 1 |
| Schomburg, L | 1 |
| Calvo, A | 1 |
| Benbrahim-Tallaa, L | 2 |
| Webber, MM | 2 |
| Waalkes, MP | 2 |
| Liu, J | 1 |
| Braslis, KG | 1 |
| Davi, RC | 1 |
| Nelson, E | 1 |
| Civantos, F | 1 |
| Soloway, MS | 1 |
| Cook, JC | 1 |
| Mullin, LS | 1 |
| Frame, SR | 1 |
| Biegel, LB | 1 |
| Schulz, P | 1 |
| Wolf, D | 1 |
| Arbusow, V | 1 |
| Bojar, H | 1 |
| Klobeck, HG | 1 |
| Fittler, F | 1 |
6 other studies available for flutamide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage.
Topics: Androgen Antagonists; Carcinoma; Cell Line, Tumor; Cell Transformation, Neoplastic; Down-Regulation; | 2011 |
Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation.
Topics: Androgen Antagonists; Androgens; Animals; Arsenic; Cell Line; Cell Proliferation; Cell Transformatio | 2005 |
Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells.
Topics: Androgen Antagonists; Androgens; Cadmium; Cell Line, Transformed; Cell Proliferation; Cell Transform | 2007 |
Squamous cell carcinoma of the prostate: a transformation from adenocarcinoma after the use of a luteinizing hormone-releasing hormone agonist and flutamide.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Flutamide; Humans; Leupro | 1995 |
Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats.
Topics: Age Factors; Androgen Antagonists; Animals; Binding, Competitive; Body Weight; Cell Transformation, | 1993 |
The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.
Topics: Androgen Antagonists; Androgens; Cell Division; Cell Transformation, Neoplastic; Cyproterone; Cyprot | 1990 |