flutamide has been researched along with Carcinoma, Hepatocellular in 9 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The growth of hepatocellular carcinoma (HCC) is thought to be dependent on androgens, as androgen receptors are present in most of these tumors." | 6.71 | Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen. ( , 2004) |
| "Flutamide is an androgen receptor (AR) antagonist approved by the United States Food and Drug Administration for the treatment of prostate cancer." | 5.42 | Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. ( Bisson, WH; Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Punj, S, 2015) |
| "The growth of hepatocellular carcinoma (HCC) is thought to be dependent on androgens, as androgen receptors are present in most of these tumors." | 2.71 | Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen. ( , 2004) |
| "Flutamide is an androgen receptor (AR) antagonist approved by the United States Food and Drug Administration for the treatment of prostate cancer." | 1.42 | Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. ( Bisson, WH; Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Punj, S, 2015) |
| "DHT promotes the hepatoma formation in vivo nude mice through PEG10 activation." | 1.34 | Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells. ( Boquan, J; Chaoqun, L; Dehua, Y; Feili, G; Hui, W; Jian, Q; Jie, X; Jinquan, T; Lang, C; Luokun, X; Qiuping, Z; Yanping, J; Yi, S; Youxin, J, 2007) |
| " To determine the antiandrogenic potential of fenitrothion in vivo, 7-week-old castrated Sprague-Dawley rats were dosed once a day for 7 days with testosterone propionate (50 microg/day, sc) plus gavage doses of either corn oil vehicle or fenitrothion (15 or 30 mg/kg/day)." | 1.31 | Androgen receptor antagonism by the organophosphate insecticide fenitrothion. ( Dorman, DC; Gaido, KW; Gray, LE; Maness, SC; Reischmann, K; Tamura, H, 2001) |
| "Flutamide was a complete agonist, whereas its hydroxylated metabolite, hydroxyflutamide, only partially antagonized and displayed some agonist activity at 10(-6) M and above." | 1.30 | Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. ( Gaido, KW; Maness, SC; McDonnell, DP, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koch, DC | 1 |
| Jang, HS | 1 |
| O'Donnell, EF | 1 |
| Punj, S | 1 |
| Kopparapu, PR | 1 |
| Bisson, WH | 1 |
| Kerkvliet, NI | 1 |
| Kolluri, SK | 1 |
| Farla, P | 1 |
| Hersmus, R | 1 |
| Trapman, J | 1 |
| Houtsmuller, AB | 1 |
| Jie, X | 1 |
| Lang, C | 1 |
| Jian, Q | 1 |
| Chaoqun, L | 1 |
| Dehua, Y | 1 |
| Yi, S | 1 |
| Yanping, J | 1 |
| Luokun, X | 1 |
| Qiuping, Z | 1 |
| Hui, W | 1 |
| Feili, G | 1 |
| Boquan, J | 1 |
| Youxin, J | 1 |
| Jinquan, T | 1 |
| Manesis, EK | 1 |
| Giannoulis, G | 1 |
| Zoumboulis, P | 1 |
| Vafiadou, I | 1 |
| Hadziyannis, SJ | 1 |
| Chao, Y | 1 |
| Chan, WK | 1 |
| Huang, YS | 1 |
| Teng, HC | 1 |
| Wang, SS | 1 |
| Lui, WY | 1 |
| Whang-Peng, J | 1 |
| Lee, SD | 1 |
| Maness, SC | 2 |
| McDonnell, DP | 1 |
| Gaido, KW | 2 |
| Liang, L | 1 |
| Lu, M | 1 |
| Huang, J | 1 |
| Tamura, H | 1 |
| Reischmann, K | 1 |
| Dorman, DC | 1 |
| Gray, LE | 1 |
3 trials available for flutamide and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen.
Topics: Adult; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Antineoplasti | 2004 |
Treatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: a randomized, controlled trial.
Topics: Analysis of Variance; Androgens; Carcinoma, Hepatocellular; Double-Blind Method; Drug Therapy, Combi | 1995 |
Phase II study of flutamide in the treatment of hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Carcinoma, Hepatocellular; Female; | 1996 |
6 other studies available for flutamide and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1.
Topics: Androgen Antagonists; Carcinoma, Hepatocellular; Cell Proliferation; Flutamide; Hep G2 Cells; Humans | 2015 |
Antiandrogens prevent stable DNA-binding of the androgen receptor.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Blotting, Western; Carcino | 2005 |
Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells.
Topics: Androgen Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Northern; Blottin | 2007 |
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Antineoplastic Agents, Hormonal; Car | 1998 |
[Antiandrogen treatment for nude mice model with ectopic transplanted human HCC].
Topics: Androgen Antagonists; Animals; Carcinoma, Hepatocellular; Flutamide; Humans; Liver Neoplasms; Male; | 1998 |
Androgen receptor antagonism by the organophosphate insecticide fenitrothion.
Topics: Acetylcholinesterase; Androgen Receptor Antagonists; Animals; Body Weight; Carcinoma, Hepatocellular | 2001 |