Page last updated: 2024-10-27

flutamide and Body Weight

flutamide has been researched along with Body Weight in 69 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
"To determine the effect of flutamide on vaginal histology, and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model."7.73Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight. ( Gumusalan, Y; Ozbag, D; Ozdemir, N; Saruhan, BG, 2005)
"Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls."7.72Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004)
" Immediately after the completion of resuscitation, as well as 24 and 48 h thereafter, the animals received either vehicle, 10 mg/kg body weight (BW) flutamide or 25 mg/kg BW flutamide subcutaneously."7.69Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997)
"Fifty NMRI mice (7-8 weeks old) were randomly divided into five groups, including non-PCOS, PCOS and PCOS groups treated with clomiphene citrate (18 mg/kg body weight for 2 days), metformin (50 mg/100 g body weight for 30 days) and flutamide (10 mg/kg body weight injection for 15 days)."4.12Metformin, clomiphene citrate and flutamide effects on oocyte ultrastructure status and quality in PCOS mouse model. ( Esmaeilnezhad, S; Ghasemian, F, 2022)
" Rats received an intraperitoneal (ip) injection of 200 mg/kg body weight of N-diethylnitrosamine (DEN) and fed a diet containing 0, 0."3.78Mechanistic study on liver tumor promoting effects of flutamide in rats. ( Hayashi, H; Inokuma, H; Mitsumori, K; Shibutani, M; Shimamoto, K; Suzuki, K; Tawfeeq, MM, 2012)
"To determine the effect of flutamide on vaginal histology, and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model."3.73Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight. ( Gumusalan, Y; Ozbag, D; Ozdemir, N; Saruhan, BG, 2005)
" Androgen receptors could not be immunohistochemically identified in the pancreas at 20 weeks, and dietary treatment with flutamide, an androgen receptor antagonist, did not influence the chronic pancreatitis."3.72Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male Wistar Bonn/Kobori rats. ( Arakawa, T; Hashimoto, T; Itoh, M; Joh, T; Kuno, A; Nakamura, S; Nakazawa, T; Nomura, T; Ohara, H; Sano, H; Sogawa, M; Takahashi, S; Yamada, T, 2003)
"Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls."3.72Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004)
"Groups of five male and five female Wistar rats were treated by gavage with 0, 1, 10, and 100 mg flutamide/kg body weight for at least 28 days to investigate whether proposed enhancements to the current subacute rodent OECD test guideline no."3.71Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandro ( Andrews, P; Becka, M; Eiben, R; Freyberger, A; Hartmann, E; Loof, I; Schmidt, U; Temerowski, M, 2001)
" Immediately after the completion of resuscitation, as well as 24 and 48 h thereafter, the animals received either vehicle, 10 mg/kg body weight (BW) flutamide or 25 mg/kg BW flutamide subcutaneously."3.69Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997)
" The present study was undertaken to determine whether androgen blockade with flutamide (15 mg/kg body weight orally daily) would influence bone turnover or bone composition (1) in female rats with intact ovaries and (2) in rats made estrogen-deficient with the luteinizing hormone releasing hormone (LHRH) agonist, buserelin (25 micrograms/kg body weight per day SC)."3.68Flutamide-mediated androgen blockade evokes osteopenia in the female rat. ( Gold, E; Goulding, A, 1993)
"Forty-nine men with prostate cancer were treated with ADT before beginning radical therapy for 6 months."2.71The influence of androgen deprivation therapy on metabolism in patients with prostate cancer. ( Anraku, T; Ishizaki, F; Nishiyama, T; Shimura, H; Takahashi, K, 2005)
"Flutamide treatment in LET females reversed elevated T levels and restored ovarian expression of Cyp17a1 (critical for androgen synthesis) to normal levels."1.48Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. ( Malik, S; Mellon, PL; Ryan, GE, 2018)
"Co-treatment with flutamide (low or high) resulted in oocyte atresia."1.43Does anti-androgen, flutamide cancel out the in vivo effects of the androgen, dihydrotestosterone on sexual development in juvenile Murray rainbowfish (Melanotaenia fluviatilis)? ( Bhatia, H; Kumar, A, 2016)
"Flutamide treatment did not affect disinhibited behavior in testosterone-treated rats."1.36The aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) reduces disinhibitory behavior in intact adult male rats treated with a high dose of testosterone. ( Svensson, AI, 2010)
"Acyline treatment reduced the number of hemorrhagic cysts and the number of Sertoli-like filled cords within ArKO ovaries."1.36The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype. ( Drummond, AE; Findlay, JK; Jones, ME; Liew, SH, 2010)
" The aim was to assess whether the joint effects of vinclozolin, flutamide, and procymidone can be predicted based on dose-response data of the individual chemicals."1.34Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures. ( Axelstad, M; Christiansen, S; Dalgaard, M; Hass, U; Kiersgaard, MK; Kortenkamp, A; Metzdorff, SB; Scholze, M; Vinggaard, AM, 2007)
"Flutamide treatment significantly attenuated the development of hypertension in female rats (systolic blood pressure: treated, 134."1.32Abolition of end-organ damage by antiandrogen treatment in female hypertensive transgenic rats. ( Andreev, D; Bader, M; Baltatu, O; Cayla, C; Iliescu, R, 2003)
"Roles of androgens in testicular tumor development have been investigated in our previous studies using double-mutant mice lacking inhibins and carrying the null testicular feminization (tfm) mutation of the androgen receptor."1.32Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis. ( Agno, JE; Burns, KH; Chen, L; Haupt, B; Korach, KS; Matzuk, MM; Ogbonna, SC, 2003)
" For the current studies, male rats were dosed for 15 days via oral gavage and euthanized on the morning of test day 15."1.31Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. ( Frame, SR; Ladics, GS; O'Connor, JC, 2002)
"Body weights were unaffected whereas liver weights were increased in prochloraz-treated animals."1.31Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz. ( Andersen, HR; Dalgaard, M; Jørgensen, EB; Nellemann, C; Vinggaard, AM, 2002)
" To determine the antiandrogenic potential of fenitrothion in vivo, 7-week-old castrated Sprague-Dawley rats were dosed once a day for 7 days with testosterone propionate (50 microg/day, sc) plus gavage doses of either corn oil vehicle or fenitrothion (15 or 30 mg/kg/day)."1.31Androgen receptor antagonism by the organophosphate insecticide fenitrothion. ( Dorman, DC; Gaido, KW; Gray, LE; Maness, SC; Reischmann, K; Tamura, H, 2001)
"Eighteen patients with prostate cancer and 17 healthy subjects matched for age and body mass index were included."1.31Hormonal regulation of appetite and body mass in patients with advanced prostate cancer treated with combined androgen blockade. ( Bryc, W; Kokot, F; Nowicki, M, 2001)
"Flutamide was used as a representative potent antiandrogen, and DDE as an example of a weakly active antiandrogen."1.31Replacement of surgical castration by GnRH-inhibition or Leydig cell ablation in the male rat Hershberger antiandrogen assay. ( Ashby, J; Deghenghi, R; Lefevre, PA; Wallis, N, 2001)
" Immature Sprague-Dawley female rats (21 days of age) were dosed daily for 20 days by oral gavage (DES, tamoxifen, and flutamide) or sc injection (testosterone)."1.31Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide. ( Han, SY; Kang, IH; Kim, HS; Kim, IY; Kim, TS; Moon, HJ; Park, KL; Seok, JH; Shin, JH, 2002)
" Rats were dosed by the intraperitoneal route for 15 days with vehicle or 0."1.30Evaluation of the primary humoral immune response following exposure of male rats to 17beta-estradiol or flutamide for 15 days. ( Cook, JC; Ladics, GS; Loveless, SE; Nicastro, SC; O'Connor, JC; Smith, C, 1998)
"Flutamide treatment resulted in higher basal levels of testosterone and stress levels of corticosterone compared to vehicle treatment, and there was no interaction of treatment with age at time of treatment."1.30Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats. ( Mahoney, E; McCormick, CM, 1999)
"Flutamide has also been shown to produce Leydig cell tumors within 1 year, presumably due to sustained hypersecretion of luteinizing hormone (LH) which occurs following disruption of the hypothalamic-pituitary-testicular (HPT) axis."1.29Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats. ( Biegel, LB; Cook, JC; Frame, SR; Mullin, LS, 1993)
"Cryptorchidism was enhanced when rats were treated postnatally with testosterone or oestradiol."1.28Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide. ( van der Schoot, P, 1992)
"Flutamide was administered SC at a daily dose of 25 mg/kg."1.27Investigation of the combination of the agonist D-Trp-6-LH-RH and the antiandrogen flutamide in the treatment of Dunning R-3327H prostate cancer model. ( Redding, TW; Schally, AV, 1985)
"Flutamide was used to investigate the mechanism involved in androgen responsive hepatic microsomal drug and steroid metabolism."1.27Effect of flutamide on hepatic cytosolic methyltrienolone (R1881) binding kinetics and testosterone responsive hepatic drug and steroid metabolism in the adult male rat. ( Bellward, GD; Pak, RC; Sunahara, GI, 1987)
"Flutamide treatment decreased the weight of accessory sex organs, stimulated the secretion of both LH (+200%) and FSH (+63%) by inhibition of the negative feedback of testosterone; endogenous testosterone secretion was increased by 363%."1.27Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan. ( Hochereau-de Reviers, MT; Perreau, C; Viguier-Martinez, MC, 1985)

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-19907 (10.14)18.7374
1990's14 (20.29)18.2507
2000's33 (47.83)29.6817
2010's14 (20.29)24.3611
2020's1 (1.45)2.80

Authors

AuthorsStudies
Ghasemian, F1
Esmaeilnezhad, S1
Zacharia, LC1
Ryan, GE1
Malik, S1
Mellon, PL1
Pallarés, ME1
Adrover, E1
Imsen, M1
González, D1
Fabre, B1
Mesch, V1
Baier, CJ1
Antonelli, MC1
Hurliman, A1
Keller Brown, J1
Maille, N1
Mandala, M1
Casson, P1
Osol, G1
da Silva, VA1
Dantas, Mde S1
Silva, LA1
Carneiro, JG1
Schamber-Reis, BL1
Bhatia, H1
Kumar, A1
Alonso-Alvarez, C1
Pérez-Rodríguez, L1
Mateo, R1
Chastel, O1
Viñuela, J1
Moon, HJ2
Kang, TS2
Kim, TS4
Kang, IH3
Ki, HY1
Kim, SH1
Han, SY4
Brill, DS1
Moenter, SM1
Han, Y1
Fu, L1
Sun, W1
Cao, J1
Xie, R1
Zhou, P1
Kang, N1
Sun, J1
Svensson, AI1
Vo, TT1
Jung, EM1
Dang, VH1
Yoo, YM1
Choi, KC1
Yu, FH1
Jeung, EB1
Campos, SG1
Gonçalves, BF1
Scarano, WR1
Corradi, LS1
Santos, FC1
Custodio, AM1
Vilamaior, PS1
Góes, RM1
Taboga, SR1
Liew, SH1
Drummond, AE1
Jones, ME1
Findlay, JK1
Jung, KK1
Kim, SS1
Baek, JH1
Nam, HS1
Hong, SK1
Lee, BM2
Hong, JT1
Oh, KW1
Kim, HS3
Shimamoto, K2
Dewa, Y1
Kemmochi, S1
Taniai, E1
Hayashi, H2
Imaoka, M1
Shibutani, M2
Mitsumori, K2
Márquez Hernández, RA1
Ohtani, J1
Fujita, T1
Sunagawa, H1
Ishikawa, E1
Tsubamoto, N1
Kawata, T1
Kaku, M1
Motokawa, M1
Tanne, K1
Tawfeeq, MM1
Suzuki, K2
Inokuma, H1
McAllan, BM1
Feay, N1
Bradley, AJ1
Geiser, F1
O'Connor, JC3
Frame, SR3
Ladics, GS2
Kwack, SJ1
Lee, RD1
Kim, IY2
Seok, JH2
Yoo, SD1
Park, KL2
Vinggaard, AM2
Nellemann, C2
Dalgaard, M2
Jørgensen, EB1
Andersen, HR1
Clark, AS1
Kelton, MC1
Whitney, AC1
Baltatu, O1
Cayla, C1
Iliescu, R1
Andreev, D1
Bader, M1
Nakamura, S1
Yamada, T2
Hashimoto, T1
Takahashi, S1
Sogawa, M1
Ohara, H1
Nakazawa, T1
Sano, H1
Kuno, A1
Joh, T1
Nomura, T1
Arakawa, T1
Itoh, M1
Yu, WJ1
Nam, SY1
Kim, YC1
Lee, BJ1
Yun, YW1
Burns, KH1
Agno, JE1
Chen, L1
Haupt, B1
Ogbonna, SC1
Korach, KS1
Matzuk, MM1
Gambineri, A1
Pagotto, U1
Tschöp, M1
Vicennati, V1
Manicardi, E1
Carcello, A1
Cacciari, M1
De Iasio, R1
Pasquali, R1
Lefevre, PA2
Ashby, J2
Zhang, GJ1
Zheng, YF1
Zhu, HJ1
Zhu, XQ1
Smith, MR1
Kunimatsu, T1
Miyata, K1
Yabushita, S1
Seki, T1
Okuno, Y1
Matsuo, M1
Nishiyama, T1
Ishizaki, F1
Anraku, T1
Shimura, H1
Takahashi, K1
Zehr, JL1
Van Meter, PE1
Wallen, K1
Goto, K1
Koizumi, K1
Takaori, H1
Fujii, Y1
Furuyama, Y1
Saika, O1
Suzuki, H1
Saito, K1
Saruhan, BG1
Ozbag, D1
Gumusalan, Y1
Ozdemir, N1
de Zegher, F1
Ibáñez, L1
Scott, HM1
Hutchison, GR1
Mahood, IK1
Hallmark, N1
Welsh, M1
De Gendt, K1
Verhoeven, G1
O'Shaughnessy, P1
Sharpe, RM1
Metzdorff, SB1
Christiansen, S1
Axelstad, M1
Hass, U1
Kiersgaard, MK1
Scholze, M1
Kortenkamp, A1
Tinwell, H1
Friry-Santini, C1
Rouquié, D1
Belluco, S1
Elies, L1
Pallen, C1
Bars, R1
Kouvelas, D1
Pourzitaki, C1
Papazisis, G1
Dagklis, T1
Dimou, K1
Kraus, MM1
Nielsen, HC1
Zinman, HM1
Torday, JS1
Brooks, JR1
Berman, C1
Hichens, M1
Primka, RL1
Reynolds, GF1
Rasmusson, GH1
Liu, A1
Flores, C1
Kinkead, T1
Carboni, AA1
Menon, M1
Seethalakshmi, L1
Russo, P1
Warner, JA1
Huryk, R1
Perez, G1
Heston, WD1
Zimmerberg, B1
Farley, MJ1
Goulding, A1
Gold, E1
Cook, JC3
Mullin, LS1
Biegel, LB1
Gallagher, AC1
Chambers, TJ1
Tobias, JH1
Wichmann, MW1
Angele, MK1
Ayala, A1
Cioffi, WG1
Chaudry, IH1
Smith, C1
Nicastro, SC1
Loveless, SE1
McCormick, CM1
Mahoney, E1
Kellogg, CK1
Lundin, A1
Mathias, LJ1
Jacobson, NA1
Rhees, RW1
Lephart, ED1
Davis, LG1
Tamura, H1
Maness, SC1
Reischmann, K1
Dorman, DC1
Gray, LE1
Gaido, KW1
Kritzer, MF1
Pugach, I1
Nowicki, M1
Bryc, W1
Kokot, F1
Andrews, P1
Freyberger, A1
Hartmann, E1
Eiben, R1
Loof, I1
Schmidt, U1
Temerowski, M1
Becka, M1
Deghenghi, R1
Wallis, N1
Shin, JH1
van der Schoot, P1
Dhar, JD1
Setty, BS2
Léger, JG1
Le Guellec, R1
Tenniswood, MP1
Gupta, G1
Srivastava, A1
Redding, TW1
Schally, AV1
Sunahara, GI1
Pak, RC1
Bellward, GD1
Viguier-Martinez, MC1
Hochereau-de Reviers, MT1
Perreau, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men Title Changed With New Protocol (12/14/09): Hormonal Regulation of HDL-C in Men[NCT00729859]Phase 231 participants (Actual)Interventional2008-12-31Completed
A Pilot Phase IV Study to Evaluate Variation in Bone Mineral Density, Lean and Fat Body Mass Index Measured by Dual-energy X-ray Absorptiometry in Patients With Prostate Cancer Without Bone Metastasis Treated With Degarelix[NCT03202381]Phase 435 participants (Anticipated)Interventional2017-06-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Endothelial Progenitor Cells

Number of CD33 + CD134+ cells as a percentage of all lymphocytes (NCT00729859)
Timeframe: Baseline, Day 28

Interventionpercentage of all lymphocytes (Mean)
BaselineDay 28
Group 1: Acyline + Placebo Gel + Placebo Pill0.1010.081

Estradiol Concentration

(NCT00729859)
Timeframe: Baseline, Day 28

,,
Interventionpmol/L (Mean)
BaselineDay 28
Group 1: Acyline + Placebo Gel, Placebo Pill95.431.9
Group 2: Acyline, Testosterone Gel117.8109.0
Group 3: Acyline, Testosterone Gel, Anastrozole Pill96.336.5

Fasting Lipid Levels

(NCT00729859)
Timeframe: Baseline, Day 28, Day 56

,,
Interventionmmol/L (Mean)
Total cholesterol Day 0Total cholesterol Day 28Total cholesterol Day 56LDL choesterol Day 0LDL cholesterol Day 28LDL cholesterol Day 56HDL cholesterol Day 0HDL cholesterol Day 28HDL cholesterol Day 56Triglycerides Day 0Triglycerides Day 28Triglycerides Day 56
Group 1: Acyline + Placebo Gel, Placebo Pill4.975.444.952.953.292.871.191.371.191.791.731.89
Group 2: Acyline, Testosterone Gel, Placebo Pill4.484.514.142.772.802.491.321.321.320.820.860.80
Group 3: Acyline, Testosterone Gel, Oral Anastrozole4.564.564.272.672.752.511.401.321.301.081.081.02

Fasting Serum Insulin

(NCT00729859)
Timeframe: Baseline, Day 28, Day 56

,,
Interventionpicomolar (Mean)
BaselineDay 28Day 56
Group 1: Acyline + Placebo Gel, Placebo Pill546954
Group 2: Acyline, Testosterone Gel, Placebo Pill655964
Group 3: Acyline, Testosterone Gel, Oral Anastrozole504250

Follicle Stimulating Hormone (FSH)

(NCT00729859)
Timeframe: Baseline, 28 days

,,
InterventionIU/L (Mean)
BaselineDay 28
Group 1: Acyline + Placebo Gel, Placebo Pill4.20.42
Group 2: Acyline, Testosterone Gel2.90.39
Group 3: Acyline, Testosterone Gel, Anastrazole Pill2.50.87

Homeostasis Model of Insulin Resistance (HOMA-IR)

HOMA IR is a measure of insulin sensitivity calculated using fasting insulin and glucose concentration in a participants blood. Higher HOMA IR numbers are associated with increased insulin resistance and decreased insulin sensitivity. (NCT00729859)
Timeframe: Baseline, Day 28, Day 56

,,
InterventionHOMA score (Mean)
BaselineDay 28Day 56
Group 1: Acyline + Placebo Gel, Placebo Pill1.82.42.2
Group 2: Acyline, Testosterone Gel, Placebo Pill2.01.91.9
Group 3: Acyline, Testosterone Gel, Oral Anastrozole1.61.41.7

Luteinizing Hormone Concentration (LH)

(NCT00729859)
Timeframe: Baseline, Day 28

,,
InterventionIU/L (Mean)
BaselineDay 28
Group 1: Acyline + Placebo Gel, Placebo Pill4.30.31
Group 2: Acyline, Testosterone Gel4.70.69
Group 3: Acyline, Testosterone Gel, Anastrozole4.41.55

Quantitative Insulin Sensitivity Check Index (QUICKI)

QUICKI is a measure of insulin sensitivity calculated using fasting insulin and glucose concentration in a participants blood. Higher QUICKI are associated with decreased insulin resistance and increased insulin sensitivity. (NCT00729859)
Timeframe: Baseline, Day 28, Day 56

,,
InterventionQUICKI index (Mean)
BaselineDay 28Day 56
Group 1: Acyline + Placebo Gel, Placebo Pill0.360.340.35
Group 2: Acyline, Testosterone Gel, Placebo Pill0.350.350.35
Group 3: Acyline, Testosterone Gel, Oral Anastrozole0.360.380.36

Sex Hormone Binding Globulin (SHBG)

(NCT00729859)
Timeframe: Baseline, Day 28

,,
Interventionnmol/L (Mean)
BaselineDay 28
Group 1: Acyline + Placebo Gel, Placebo Pill34.937.5
Group 2: Acyline, Testosterone Gel23.022.1
Group 3: Acyline, Testosterone Gel, Anastrozole Pill27.625.1

Testosterone Concentration

(NCT00729859)
Timeframe: Baseline, Day 28

,,
Interventionnmol/L (Mean)
Baseline testosterone concentrationDay 28 testosterone concentration
Group 1: Acyline + Placebo Gel, Placebo Pill15.40.8
Group 2: Acyline, Testosterone Gel16.317.8
Group 3: Acyline, Testosterone Gel, Anastrozole16.519.0

Reviews

1 review available for flutamide and Body Weight

ArticleYear
Permitted Daily Exposure of the Androgen Receptor Antagonist Flutamide.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 10-01, Volume: 159, Issue:2

    Topics: Administration, Oral; Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug;

2017

Trials

3 trials available for flutamide and Body Weight

ArticleYear
Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome.
    Journal of endocrinological investigation, 2003, Volume: 26, Issue:7

    Topics: Adult; Androgen Antagonists; Androstenedione; Blood Glucose; Body Composition; Body Weight; Female;

2003
Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer.
    Urology, 2004, Volume: 63, Issue:4

    Topics: Adipose Tissue; Adult; Aged; Androgen Antagonists; Body Composition; Body Mass Index; Body Weight; F

2004
Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer.
    Urology, 2004, Volume: 63, Issue:4

    Topics: Adipose Tissue; Adult; Aged; Androgen Antagonists; Body Composition; Body Mass Index; Body Weight; F

2004
Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer.
    Urology, 2004, Volume: 63, Issue:4

    Topics: Adipose Tissue; Adult; Aged; Androgen Antagonists; Body Composition; Body Mass Index; Body Weight; F

2004
Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer.
    Urology, 2004, Volume: 63, Issue:4

    Topics: Adipose Tissue; Adult; Aged; Androgen Antagonists; Body Composition; Body Mass Index; Body Weight; F

2004
The influence of androgen deprivation therapy on metabolism in patients with prostate cancer.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:2

    Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Androgen Antagonists; Blood Glucose; Blood Urea Nit

2005

Other Studies

65 other studies available for flutamide and Body Weight

ArticleYear
Metformin, clomiphene citrate and flutamide effects on oocyte ultrastructure status and quality in PCOS mouse model.
    Reproductive biomedicine online, 2022, Volume: 45, Issue:2

    Topics: Animals; Body Weight; Clomiphene; Female; Fertility Agents, Female; Flutamide; Humans; Infertility,

2022
Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.
    Endocrinology, 2018, 04-01, Volume: 159, Issue:4

    Topics: Adipocytes; Androgen Antagonists; Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal

2018
Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring.
    Neuroscience, 2014, Oct-10, Volume: 278

    Topics: Androgen Antagonists; Androgens; Animals; Body Weight; Brain; Female; Flutamide; Hippocampus; Male;

2014
Hyperandrogenism and Insulin Resistance, Not Changes in Body Weight, Mediate the Development of Endothelial Dysfunction in a Female Rat Model of Polycystic Ovary Syndrome (PCOS).
    Endocrinology, 2015, Volume: 156, Issue:11

    Topics: Androgen Antagonists; Androgens; Animals; Arteries; Blood Pressure; Body Weight; Dihydrotestosterone

2015
Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides: A Preliminary Study.
    BioMed research international, 2015, Volume: 2015

    Topics: Androgen Antagonists; Animals; Body Weight; Brain; Cell Adhesion Molecules, Neuronal; Cerebellum; Cp

2015
Does anti-androgen, flutamide cancel out the in vivo effects of the androgen, dihydrotestosterone on sexual development in juvenile Murray rainbowfish (Melanotaenia fluviatilis)?
    Aquatic toxicology (Amsterdam, Netherlands), 2016, Volume: 170

    Topics: Androgen Antagonists; Androgens; Animals; Body Weight; Dihydrotestosterone; Environmental Exposure;

2016
The oxidation handicap hypothesis and the carotenoid allocation trade-off.
    Journal of evolutionary biology, 2008, Volume: 21, Issue:6

    Topics: Androgen Antagonists; Androgens; Animals; Body Weight; Carotenoids; Female; Flutamide; Galliformes;

2008
OECD validation of phase 3 Hershberger assay in Korea using surgically castrated male rats with coded chemicals.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:4

    Topics: Anabolic Agents; Androgen Antagonists; Androgens; Animals; Biological Assay; Body Weight; Dichlorodi

2009
Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by high-fat diet in mice.
    Biology of reproduction, 2009, Volume: 81, Issue:6

    Topics: Analysis of Variance; Androgen Antagonists; Animals; Body Weight; Diet, Fat-Restricted; Dietary Fats

2009
Neuroprotective effects of testosterone upon cardiac sympathetic function in rats with induced heart failure.
    European journal of pharmacology, 2009, Oct-01, Volume: 619, Issue:1-3

    Topics: Androgen Antagonists; Animals; Blotting, Western; Body Weight; Castration; Flutamide; Gene Expressio

2009
The aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) reduces disinhibitory behavior in intact adult male rats treated with a high dose of testosterone.
    Behavioural brain research, 2010, Jan-20, Volume: 206, Issue:2

    Topics: Analysis of Variance; Androgen Antagonists; Androgens; Androstatrienes; Animals; Behavior, Animal; B

2010
Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats.
    Reproductive biology and endocrinology : RB&E, 2009, Sep-26, Volume: 7

    Topics: Androgen Antagonists; Animals; Body Weight; Diethylhexyl Phthalate; Dose-Response Relationship, Drug

2009
Tissue changes in senescent gerbil prostate after hormone deprivation leads to acquisition of androgen insensitivity.
    International journal of experimental pathology, 2010, Volume: 91, Issue:5

    Topics: Aging; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Apoptosis; Body We

2010
The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.
    Molecular and cellular endocrinology, 2010, Oct-07, Volume: 327, Issue:1-2

    Topics: Animals; Aromatase; Body Weight; Corpus Luteum; Estradiol; Estrogens; Estrous Cycle; Female; Flutami

2010
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:21-22

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht

2010
Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats.
    Archives of toxicology, 2011, Volume: 85, Issue:9

    Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Enzyme Induc

2011
Mandibular and femoral growth alteration after sex hormone disruption in growing mice.
    Orthodontics & craniofacial research, 2011, Volume: 14, Issue:2

    Topics: Age Factors; Androgen Receptor Antagonists; Animals; Body Weight; Cephalometry; Epiphyses; Estrogen

2011
Mechanistic study on liver tumor promoting effects of flutamide in rats.
    Archives of toxicology, 2012, Volume: 86, Issue:3

    Topics: Androgen Antagonists; Animals; Body Weight; Diethylnitrosamine; Flutamide; Immunohistochemistry; Lip

2012
The influence of reproductive hormones on the torpor patterns of the marsupial Sminthopsis macroura: bet-hedging in an unpredictable environment.
    General and comparative endocrinology, 2012, Nov-01, Volume: 179, Issue:2

    Topics: Adaptation, Physiological; Animals; Basal Metabolism; Body Temperature; Body Temperature Regulation;

2012
Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 69, Issue:1

    Topics: Androgen Antagonists; Androgens; Animals; Body Weight; Cyproterone Acetate; Dichlorodiphenyl Dichlor

2002
No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats.
    Toxicology letters, 2002, Sep-05, Volume: 135, Issue:1-2

    Topics: Androgen Antagonists; Animals; Benzhydryl Compounds; Body Weight; Estrogens, Non-Steroidal; Flutamid

2002
Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 69, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Body Weight; DNA, Complementary; Fluta

2002
Chronic administration of anabolic steroids disrupts pubertal onset and estrous cyclicity in rats.
    Biology of reproduction, 2003, Volume: 68, Issue:2

    Topics: Anabolic Agents; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Body Weight; Drug Adm

2003
Abolition of end-organ damage by antiandrogen treatment in female hypertensive transgenic rats.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:3 Pt 2

    Topics: Albuminuria; Androgen Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents;

2003
Estradiol alleviates acinar cell apoptosis and chronic pancreatitis in male Wistar Bonn/Kobori rats.
    Pancreas, 2003, Volume: 26, Issue:3

    Topics: Androgen Antagonists; Animals; Apoptosis; Body Weight; Cell Movement; Chronic Disease; Estradiol; Fl

2003
Effects of tributyltin chloride on the reproductive system in pubertal male rats.
    Journal of veterinary science, 2003, Volume: 4, Issue:1

    Topics: Animals; Body Weight; Epididymis; Flutamide; Genitalia, Male; Male; Methyltestosterone; Organ Size;

2003
Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:10

    Topics: Androgens; Animals; Body Weight; Cachexia; Cyclin D2; Cyclins; Estrogen Receptor alpha; Estrogen Rec

2003
Comparison of prostate gene expression and tissue weight changes as monitors of antiandrogen activity in GNRH-inhibited rats.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2003, Volume: 68, Issue:4

    Topics: Androgen Antagonists; Androgen-Binding Protein; Animals; Biomarkers; Body Weight; Clusterin; Dichlor

2003
[The antiandrogenic effect of dimethachlon and its mechanism].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2004, Volume: 22, Issue:1

    Topics: Aminoimidazole Carboxamide; Androgen Antagonists; Androgens; Animals; Body Weight; Bridged Bicyclo C

2004
Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide.
    Toxicology, 2004, Jul-15, Volume: 200, Issue:1

    Topics: Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug; Evaluation Studies as

2004
Factors regulating the timing of puberty onset in female rhesus monkeys (Macaca mulatta): role of prenatal androgens, social rank, and adolescent body weight.
    Biology of reproduction, 2005, Volume: 72, Issue:5

    Topics: Age Factors; Androgen Antagonists; Androgens; Animals; Body Weight; Female; Flutamide; Gestational A

2005
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
    The Journal of toxicological sciences, 2004, Volume: 29, Issue:5

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation

2004
Influence of ovariectomy and flutamide treatment on vaginal tissue and body weight.
    Saudi medical journal, 2005, Volume: 26, Issue:12

    Topics: Androgen Antagonists; Animals; Body Weight; Disease Models, Animal; Female; Flutamide; Immunohistoch

2005
Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.
    Fertility and sterility, 2006, Volume: 86 Suppl 1

    Topics: Aging; Androgen Antagonists; Body Weight; Child; Drug Therapy, Combination; Female; Fetal Developmen

2006
Role of androgens in fetal testis development and dysgenesis.
    Endocrinology, 2007, Volume: 148, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Androgen Antagonists; Animals; Body Weight; Carcinogens; Dibutyl P

2007
Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 98, Issue:1

    Topics: Algorithms; Androgen Antagonists; Animals; Body Weight; Bridged Bicyclo Compounds; Endpoint Determin

2007
Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 100, Issue:1

    Topics: Adrenal Glands; Androgen Antagonists; Animals; Biomarkers, Pharmacological; Body Weight; Dichlorodip

2007
Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors.
    The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:7

    Topics: Anabolic Agents; Androgen Antagonists; Animals; Anxiety; Behavior, Animal; Body Weight; Brain Chemis

2008
Dihydrotestosterone inhibits fetal rabbit pulmonary surfactant production.
    The Journal of clinical investigation, 1982, Volume: 69, Issue:3

    Topics: Animals; Body Weight; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Flutamide; Huma

1982
Biological activities of a new steroidal inhibitor of delta 4-5 alpha-reductase.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1982, Volume: 169, Issue:1

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Azasteroids; Body Weig

1982
Effects of sialoadenectomy and epidermal growth factor on testicular function of sexually mature male mice.
    The Journal of urology, 1994, Volume: 152, Issue:2 Pt 1

    Topics: Animals; Body Weight; Epidermal Growth Factor; Flutamide; Follicle Stimulating Hormone; Luteinizing

1994
TRPM-2 gene expression in normal rat ventral prostate following castration and exposure to diethylstilbestrol, flutamide, MK-906 (finasteride), and coumarin.
    The Prostate, 1994, Volume: 24, Issue:5

    Topics: Animals; Apoptosis; Body Weight; Clusterin; Coumarins; Diethylstilbestrol; Finasteride; Flutamide; G

1994
Sex differences in anxiety behavior in rats: role of gonadal hormones.
    Physiology & behavior, 1993, Volume: 54, Issue:6

    Topics: Animals; Animals, Newborn; Anxiety; Appetitive Behavior; Arousal; Body Weight; Conditioning, Operant

1993
Flutamide-mediated androgen blockade evokes osteopenia in the female rat.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1993, Volume: 8, Issue:6

    Topics: Androgens; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Buserelin; Female; Flutamid

1993
Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats.
    Toxicology and applied pharmacology, 1993, Volume: 119, Issue:2

    Topics: Age Factors; Androgen Antagonists; Animals; Binding, Competitive; Body Weight; Cell Transformation,

1993
Androgens contribute to the stimulation of cancellous bone formation by ovarian hormones in female rats.
    The American journal of physiology, 1996, Volume: 270, Issue:3 Pt 1

    Topics: Animals; Body Weight; Bone and Bones; Bone Resorption; Dihydrotestosterone; Diphosphonates; Female;

1996
Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.
    Shock (Augusta, Ga.), 1997, Volume: 8, Issue:4

    Topics: Animals; Body Weight; Corticosterone; Flutamide; Immunity, Cellular; Injections, Subcutaneous; Inter

1997
Evaluation of the primary humoral immune response following exposure of male rats to 17beta-estradiol or flutamide for 15 days.
    Toxicological sciences : an official journal of the Society of Toxicology, 1998, Volume: 46, Issue:1

    Topics: Androgen Antagonists; Animals; Body Weight; Cell Count; Environmental Pollutants; Estradiol; Flutami

1998
Persistent effects of prenatal, neonatal, or adult treatment with flutamide on the hypothalamic-pituitary-adrenal stress response of adult male rats.
    Hormones and behavior, 1999, Volume: 35, Issue:1

    Topics: Age Factors; Anal Canal; Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Corticosteron

1999
Brain androgen-inducible aromatase is critical for adolescent organization of environment-specific social interaction in male rats.
    Hormones and behavior, 1999, Volume: 35, Issue:2

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adaptation, Physiological; Adap

1999
Brain aromatase in control versus castrated Norway Brown, Sprague-Dawley and Wistar adult rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 221, Issue:2

    Topics: Amygdala; Androgen Antagonists; Animals; Aromatase; Body Weight; Brain; Castration; Flutamide; Hypot

1999
Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay.
    Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 51, Issue:1

    Topics: Animals; Body Weight; Dichlorodiphenyl Dichloroethylene; Disease Models, Animal; Flutamide; Gonadal

1999
Androgen receptor antagonism by the organophosphate insecticide fenitrothion.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 60, Issue:1

    Topics: Acetylcholinesterase; Androgen Receptor Antagonists; Animals; Body Weight; Carcinoma, Hepatocellular

2001
Administration of tamoxifen but not flutamide to hormonally intact, adult male rats mimics the effects of short-term gonadectomy on the catecholamine innervation of the cerebral cortex.
    The Journal of comparative neurology, 2001, Mar-19, Volume: 431, Issue:4

    Topics: Animals; Axons; Body Weight; Cerebral Cortex; Dopamine; Dopamine beta-Hydroxylase; Flutamide; Male;

2001
Hormonal regulation of appetite and body mass in patients with advanced prostate cancer treated with combined androgen blockade.
    Journal of endocrinological investigation, 2001, Volume: 24, Issue:1

    Topics: Adenocarcinoma; Aged; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Appetite

2001
Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandro
    Archives of toxicology, 2001, Volume: 75, Issue:2

    Topics: Administration, Oral; Androgen Antagonists; Animals; Behavior, Animal; Body Weight; Clinical Chemist

2001
Replacement of surgical castration by GnRH-inhibition or Leydig cell ablation in the male rat Hershberger antiandrogen assay.
    Regulatory toxicology and pharmacology : RTP, 2001, Volume: 34, Issue:2

    Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Animals; Body Weight; Dichlorodiphenyl Dichloroe

2001
Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 67, Issue:1

    Topics: Administration, Oral; Animals; Body Weight; Diethylstilbestrol; Dose-Response Relationship, Drug; Es

2002
Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide.
    Journal of reproduction and fertility, 1992, Volume: 96, Issue:2

    Topics: Androgen-Insensitivity Syndrome; Animals; Body Weight; Chi-Square Distribution; Cryptorchidism; Epid

1992
Effect of a nonsteroidal antiandrogen, anandron, on the reproductive system and fertility in male rats.
    Contraception, 1990, Volume: 42, Issue:1

    Topics: Alkaline Phosphatase; Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug;

1990
Treatment with antiandrogens induces an androgen-repressed gene in the rat ventral prostate.
    The Prostate, 1988, Volume: 13, Issue:2

    Topics: Androgen Antagonists; Androgens; Animals; Blotting, Northern; Body Weight; Cell Survival; Cell-Free

1988
Effect of antiandrogens on some key enzymes of glycolysis in epididymis and ventral prostate of rat.
    Indian journal of experimental biology, 1989, Volume: 27, Issue:4

    Topics: Androgen Antagonists; Animals; Body Weight; Cyproterone; Cyproterone Acetate; Enzymes; Epididymis; E

1989
Investigation of the combination of the agonist D-Trp-6-LH-RH and the antiandrogen flutamide in the treatment of Dunning R-3327H prostate cancer model.
    The Prostate, 1985, Volume: 6, Issue:3

    Topics: Anilides; Animals; Body Weight; Cell Line; Drug Therapy, Combination; Flutamide; Gonadotropin-Releas

1985
Effect of flutamide on hepatic cytosolic methyltrienolone (R1881) binding kinetics and testosterone responsive hepatic drug and steroid metabolism in the adult male rat.
    Biochemical pharmacology, 1987, Nov-01, Volume: 36, Issue:21

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen-Binding Protein; Anilides; Animals; Aryl Hydrocarbon

1987
Effects of flutamide or of supplementation with testosterone in prepubertal male rats prenatally treated with busulfan.
    Acta endocrinologica, 1985, Volume: 109, Issue:4

    Topics: Anilides; Animals; Body Weight; Busulfan; Female; Flutamide; Follicle Stimulating Hormone; Hypothala

1985