Page last updated: 2024-10-27

flutamide and Alopecia

flutamide has been researched along with Alopecia in 14 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Alopecia: Absence of hair from areas where it is normally present.

Research Excerpts

ExcerptRelevanceReference
"Topical hydroalcoholic solution of flutamide plus minoxidil may be promising treatment for the androgenetic alopecia."9.51Comparison between "5% minoxidil plus 2% flutamide" solution vs. "5% minoxidil" solution in the treatment of androgenetic alopecia. ( Faghihi, G; Hoseyni, MS; Iraji, F; Jelvan, M; Saber, M; Siadat, AH, 2022)
"Flutamide is a potent anti-androgen with the several unwanted side effects in systemic administration, therefore, it has attracted special interest in the development of topically applied formulations for the treatment of androgenic alopecia."7.83Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia. ( Adib, ZM; Ghanbarzadeh, S; Hamishehkar, H; Javadzadeh, Y; Kouhsoltani, M; Sepehran, S, 2016)
"Topical hydroalcoholic solution of flutamide plus minoxidil may be promising treatment for the androgenetic alopecia."5.51Comparison between "5% minoxidil plus 2% flutamide" solution vs. "5% minoxidil" solution in the treatment of androgenetic alopecia. ( Faghihi, G; Hoseyni, MS; Iraji, F; Jelvan, M; Saber, M; Siadat, AH, 2022)
"Flutamide at a dose of 250 mg daily induced a modest improvement in alopecia after 1 year, whereas cyproterone acetate and finasteride were not effective."5.10Treatment of hyperandrogenic alopecia in women. ( Carmina, E; Lobo, RA, 2003)
"Flutamide is a potent anti-androgen with the several unwanted side effects in systemic administration, therefore, it has attracted special interest in the development of topically applied formulations for the treatment of androgenic alopecia."3.83Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia. ( Adib, ZM; Ghanbarzadeh, S; Hamishehkar, H; Javadzadeh, Y; Kouhsoltani, M; Sepehran, S, 2016)
"Both groups showed a marked decrease in alopecia scores after 12 months of flutamide therapy, compared with baseline values."3.77Prospective cohort study on the effects and tolerability of flutamide in patients with female pattern hair loss. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011)
"Common types of nonscarring hair loss, including female pattern hair loss and telogen effluvium, may be diagnosed and managed by the obstetrician/gynecologist."2.52Hair loss in women. ( Bechtel, MA; Harfmann, KL, 2015)
"Female pattern hair loss, or female pattern androgenetic alopecia, is a nonscarring alopecia with a multi-factorial etiology that mostly affects postmenopausal women and is characterized by a reduction in hair density over the crown and frontal scalp."2.52Female pattern hair loss. ( Ioannides, D; Lazaridou, E, 2015)
"Flutamide was found to be more effective than spironolactone or cyproterone in one study."2.44A review of hormonal therapy for female pattern (androgenic) alopecia. ( Scheinfeld, N, 2008)
"Although hirsutism and androgenetic alopecia are cosmetic problems, they can be psychologically devastating for women."2.40Antiandrogen treatment of polycystic ovary syndrome. ( Rittmaster, RS, 1999)
"Female pattern hair loss is a common but difficult to manage condition."1.37Treatment of female pattern hair loss with the androgen receptor antagonist flutamide. ( Sinclair, R; Yazdabadi, A, 2011)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's9 (64.29)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Faghihi, G1
Iraji, F1
Siadat, AH1
Saber, M1
Jelvan, M1
Hoseyni, MS1
Azarchi, S1
Bienenfeld, A1
Lo Sicco, K1
Marchbein, S1
Shapiro, J1
Nagler, AR1
Buzney, E1
Sheu, J1
Buzney, C1
Reynolds, RV1
Harfmann, KL1
Bechtel, MA1
Hamishehkar, H1
Ghanbarzadeh, S1
Sepehran, S1
Javadzadeh, Y1
Adib, ZM1
Kouhsoltani, M1
Ioannides, D1
Lazaridou, E1
Scheinfeld, N1
Crabtree, JS1
Kilbourne, EJ1
Peano, BJ1
Chippari, S1
Kenney, T1
McNally, C1
Wang, W1
Harris, HA1
Winneker, RC1
Nagpal, S1
Thompson, CC1
Walker, WH1
Paradisi, R1
Porcu, E1
Fabbri, R1
Seracchioli, R1
Battaglia, C1
Venturoli, S1
Yazdabadi, A1
Sinclair, R1
Carmina, E1
Lobo, RA1
Rittmaster, RS1
Sintov, A1
Serafimovich, S1
Gilhar, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.[NCT02548689]10 participants (Actual)Observational2015-07-31Terminated (stopped due to Original lead investigator left Northwestern University)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for flutamide and Alopecia

ArticleYear
Androgens in women: Hormone-modulating therapies for skin disease.
    Journal of the American Academy of Dermatology, 2019, Volume: 80, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Alopecia; Androgen Ant

2019
Polycystic ovary syndrome: a review for dermatologists: Part II. Treatment.
    Journal of the American Academy of Dermatology, 2014, Volume: 71, Issue:5

    Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Alopecia; Androgen Antagonists; Contraceptives, Oral, C

2014
Hair loss in women.
    Clinical obstetrics and gynecology, 2015, Volume: 58, Issue:1

    Topics: 5-alpha Reductase Inhibitors; Alopecia; Androgen Antagonists; Female; Finasteride; Flutamide; Hair;

2015
Female pattern hair loss.
    Current problems in dermatology, 2015, Volume: 47

    Topics: 5-alpha Reductase Inhibitors; Administration, Cutaneous; Alopecia; Androgen Antagonists; Androgen Re

2015
A review of hormonal therapy for female pattern (androgenic) alopecia.
    Dermatology online journal, 2008, Mar-15, Volume: 14, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Alopecia; Androgen Antagonists; Androgens; Cyproterone Acetate; Dermat

2008
Antiandrogen treatment of polycystic ovary syndrome.
    Endocrinology and metabolism clinics of North America, 1999, Volume: 28, Issue:2

    Topics: Alopecia; Androgen Antagonists; Androgens; Cyproterone Acetate; Female; Finasteride; Flutamide; Hirs

1999

Trials

2 trials available for flutamide and Alopecia

ArticleYear
Comparison between "5% minoxidil plus 2% flutamide" solution vs. "5% minoxidil" solution in the treatment of androgenetic alopecia.
    Journal of cosmetic dermatology, 2022, Volume: 21, Issue:10

    Topics: Administration, Topical; Alopecia; Finasteride; Flutamide; Humans; Minoxidil; Treatment Outcome

2022
Treatment of hyperandrogenic alopecia in women.
    Fertility and sterility, 2003, Volume: 79, Issue:1

    Topics: 5-alpha Reductase Inhibitors; Adult; Alopecia; Androgen Antagonists; Cyproterone Acetate; Dehydroepi

2003

Other Studies

6 other studies available for flutamide and Alopecia

ArticleYear
Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia.
    Drug development and industrial pharmacy, 2016, Volume: 42, Issue:6

    Topics: Administration, Cutaneous; Alopecia; Androgen Antagonists; Animals; Chemistry, Pharmaceutical; Drug

2016
A mouse model of androgenetic alopecia.
    Endocrinology, 2010, Volume: 151, Issue:5

    Topics: Alopecia; Androgen Antagonists; Androgens; Animals; beta Catenin; Blotting, Western; Cell Line; Cell

2010
Is the "comb over" dying? A mouse model for male pattern baldness (androgenic alopecia).
    Endocrinology, 2010, Volume: 151, Issue:5

    Topics: Alopecia; Androgen Antagonists; Androgens; Animals; beta Catenin; Dihydrotestosterone; Disease Model

2010
Prospective cohort study on the effects and tolerability of flutamide in patients with female pattern hair loss.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Alopecia; Androgen Antagonists; Cohort Studies; Contraceptives, Oral; Female; Flu

2011
Treatment of female pattern hair loss with the androgen receptor antagonist flutamide.
    The Australasian journal of dermatology, 2011, Volume: 52, Issue:2

    Topics: Adult; Alopecia; Androgen Receptor Antagonists; Drug Therapy, Combination; Female; Flutamide; Hair;

2011
New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice.
    International journal of pharmaceutics, 2000, Jan-20, Volume: 194, Issue:1

    Topics: Administration, Topical; Alopecia; Androgen Antagonists; Animals; Finasteride; Flutamide; Hair Folli

2000