flutamide and Aging
flutamide has been researched along with Aging in 30 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to treat aging (7-8 months) +/- follicle-stimulating hormone receptor mice that are destined for reproductive failure with 2 selected antiandrogens, curcumin and flutamide, to counteract deleterious effects of mild hyperandrogenemia on the ovary and metabolism." | 7.75 | Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice. ( Ram Sairam, M; Tiwari-Pandey, R, 2009) |
| "To investigate the responsiveness of the healthy aging male hypothalamo-pituitary-gonadal axis to short term interruption of androgen negative feedback, we administered a selective nonsteroidal competitive antagonist of the androgen receptor, flutamide hydrochloride (250 mg, orally, three times daily for 3." | 3.69 | Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback. ( Dufau, ML; Urban, RJ; Veldhuis, JD, 1994) |
| "Flutamide (Flu) is an anti-androgenic compound that disrupts development of male androgen-dependent tissues." | 1.32 | Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes. ( Anahara, R; Mori, C; Toyama, Y, 2004) |
| "Flutamide treatment resulted in a reduced size of two forebrain nuclei that are known to play some role unique to early phases of song learning [lateral magnocellular nucleus of the anterior neostriatum (IMAN) and area X (X)], but did not affect the size of two song-control nuclei that are necessary for normal song production in adult birds [caudal nucleus of the ventral hyperstriatum (HVc) and robust nucleus of the archistriatum (RA)]." | 1.28 | Castration and antisteroid treatment impair vocal learning in male zebra finches. ( Bottjer, SW; Hewer, SJ, 1992) |
Research
Studies (30)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Campos, SG | 2 |
| Gonçalves, BF | 2 |
| Scarano, WR | 2 |
| Góes, RM | 2 |
| Taboga, SR | 2 |
| Takahashi, PY | 1 |
| Liu, PY | 1 |
| Veldhuis, JD | 2 |
| Hsu, SC | 1 |
| Huang, SM | 1 |
| Lin, SH | 1 |
| Ka, SM | 1 |
| Chen, A | 1 |
| Shih, MF | 1 |
| Hsu, YJ | 1 |
| Legacki, E | 1 |
| Conley, AJ | 1 |
| Nitta-Oda, BJ | 1 |
| Berger, T | 1 |
| Jian-xin, J | 1 |
| Cheng-li, C | 1 |
| Song, W | 1 |
| Yan, XS | 1 |
| Huo, DS | 1 |
| Wang, H | 1 |
| Yang, ZJ | 1 |
| Cheng, J | 1 |
| Hu, W | 1 |
| Toung, TJ | 1 |
| Zhang, Z | 1 |
| Parker, SM | 1 |
| Roselli, CE | 1 |
| Hurn, PD | 1 |
| Tiwari-Pandey, R | 1 |
| Ram Sairam, M | 1 |
| Corradi, LS | 1 |
| Santos, FC | 1 |
| Custodio, AM | 1 |
| Vilamaior, PS | 1 |
| Montalvo, L | 1 |
| Sánchez-Chapado, M | 1 |
| Prieto, JC | 1 |
| Carmena, MJ | 1 |
| Fisher, JS | 1 |
| Pastor-Soler, N | 1 |
| Sharpe, RM | 1 |
| Breton, S | 1 |
| Hwang, DY | 1 |
| Cho, JS | 1 |
| Chae, KR | 1 |
| Kang, TS | 1 |
| Hwang, JH | 1 |
| Lim, CH | 1 |
| Lee, SH | 1 |
| Lim, HJ | 1 |
| Min, SH | 1 |
| Sheen, YY | 1 |
| Jang, IS | 1 |
| Kim, YK | 1 |
| Hotchkiss, AK | 1 |
| Ostby, JS | 1 |
| Vandenbergh, JG | 1 |
| Gray, LE | 1 |
| Anahara, R | 1 |
| Toyama, Y | 1 |
| Mori, C | 1 |
| Magnaghi, V | 1 |
| Ballabio, M | 1 |
| Gonzalez, LC | 1 |
| Leonelli, E | 1 |
| Motta, M | 1 |
| Melcangi, RC | 1 |
| Maire, M | 1 |
| Florin, A | 1 |
| Kaszas, K | 1 |
| Regnier, D | 1 |
| Contard, P | 1 |
| Tabone, E | 1 |
| Mauduit, C | 1 |
| Bars, R | 1 |
| Benahmed, M | 1 |
| de Zegher, F | 1 |
| Ibáñez, L | 1 |
| Breedlove, SM | 1 |
| Arnold, AP | 1 |
| Kloss, MW | 1 |
| Rosen, GM | 1 |
| Rauckman, EJ | 1 |
| Padilla, GM | 1 |
| Gladue, BA | 1 |
| Clemens, LG | 1 |
| Brooks, JR | 1 |
| Baptista, EM | 1 |
| Berman, C | 1 |
| Ham, EA | 1 |
| Hichens, M | 1 |
| Johnston, DB | 1 |
| Primka, RL | 1 |
| Rasmusson, GH | 1 |
| Reynolds, GF | 1 |
| Schmitt, SM | 1 |
| Arth, GE | 1 |
| Kerr, JE | 1 |
| Allore, RJ | 1 |
| Beck, SG | 1 |
| Handa, RJ | 1 |
| Urban, RJ | 1 |
| Dufau, ML | 1 |
| Tena-Sempere, M | 1 |
| Pinilla, L | 1 |
| Aguilar, E | 1 |
| McAbee, MD | 1 |
| Doncarlos, LL | 1 |
| Pazos, F | 1 |
| Sánchez-Franco, F | 1 |
| Balsa, JA | 1 |
| Escalada, J | 1 |
| Palacios, N | 1 |
| Cacicedo, L | 1 |
| Banu, SK | 1 |
| Govindarajulu, P | 1 |
| Aruldhas, MM | 1 |
| Uzunova, A | 1 |
| Ramey, E | 1 |
| Ramwell, PW | 1 |
| Bottjer, SW | 1 |
| Hewer, SJ | 1 |
| Ceda, GP | 1 |
| Ceresini, G | 1 |
| Denti, L | 1 |
| Cortellini, P | 1 |
| Hoffman, AR | 1 |
| Valenti, G | 1 |
| Dhar, JD | 1 |
| Setty, BS | 1 |
Trials
1 trial available for flutamide and Aging
| Article | Year |
|---|---|
Distinct roles of age and abdominal visceral fat in reducing androgen receptor-dependent negative feedback on LH secretion in healthy men.
Topics: Adult; Aged; Aging; Androgen Antagonists; Cross-Over Studies; Double-Blind Method; Feedback; Flutami | 2014 |
Other Studies
29 other studies available for flutamide and Aging
| Article | Year |
|---|---|
Phenotypic and metabolic aspects of prostatic epithelial cells in aged gerbils after antisteroidal therapy: turnover in the state of chromatin condensation and androgen-independent cell replacement.
Topics: Aging; Androgen Antagonists; Androgens; Animals; Cell Proliferation; Chromatin Assembly and Disassem | 2014 |
Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway.
Topics: Aging; Animals; Estrogens; Flutamide; Gene Expression Regulation; Glucuronidase; Kidney; Klotho Prot | 2014 |
Porcine sertoli cell proliferation after androgen receptor inactivation.
Topics: Aging; Androgen Receptor Antagonists; Animals; Cell Proliferation; Flutamide; Gene Expression; Gonad | 2015 |
Effects of Testosterone Treatment on Synaptic Plasticity and Behavior in Senescence Accelerated Mice.
Topics: Aging; Androgen Antagonists; Androgens; Animals; Behavior, Animal; Cognition; Cyclic AMP Response El | 2015 |
Age-dependent effects of testosterone in experimental stroke.
Topics: Aging; Androgen Antagonists; Animals; Aromatase; Castration; Flutamide; Infarction, Middle Cerebral | 2009 |
Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice.
Topics: Abdominal Fat; Aging; Animals; Curcumin; Female; Flutamide; Haploidy; Mice; Mice, Transgenic; Obesit | 2009 |
Tissue changes in senescent gerbil prostate after hormone deprivation leads to acquisition of androgen insensitivity.
Topics: Aging; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Apoptosis; Body We | 2010 |
Regulation of the expression of protein kinase C isoenzymes in rat ventral prostate: effects of age, castration and flutamide treatment.
Topics: Aging; Androgen Antagonists; Animals; Blotting, Western; Flutamide; Injections, Subcutaneous; Isoenz | 2002 |
Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis.
Topics: Aging; Androgen Antagonists; Animals; Animals, Newborn; Blotting, Western; Cell Count; Diethylstilbe | 2002 |
Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens.
Topics: Aging; Androgen Antagonists; Androgens; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP | 2003 |
An environmental antiandrogen, vinclozolin, alters the organization of play behavior.
Topics: Aging; Androgen Antagonists; Animals; Animals, Newborn; Behavior, Animal; Female; Flutamide; Fungici | 2003 |
Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes.
Topics: Acrosome; Aging; Androgen Antagonists; Animals; Animals, Newborn; Cell Nucleus; Flutamide; Male; Mic | 2004 |
The synthesis of glycoprotein Po and peripheral myelin protein 22 in sciatic nerve of male rats is modulated by testosterone metabolites.
Topics: Aging; Androgen Antagonists; Animals; Flutamide; Male; Myelin P0 Protein; Myelin Proteins; Orchiecto | 2004 |
Alteration of transforming growth factor-beta signaling system expression in adult rat germ cells with a chronic apoptotic cell death process after fetal androgen disruption.
Topics: Aging; Androgen Antagonists; Animals; Apoptosis; Dose-Response Relationship, Drug; Fas Ligand Protei | 2005 |
Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.
Topics: Aging; Androgen Antagonists; Body Weight; Child; Drug Therapy, Combination; Female; Fetal Developmen | 2006 |
Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide.
Topics: Aging; Anilides; Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Muscle Development; Neur | 1983 |
Androgenic suppression of mouse hepatic FAD-containing monooxygenase activity.
Topics: Aging; Animals; Castration; Female; Flutamide; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Mi | 1982 |
Development of feminine sexual behavior in the rat: androgenic and temporal influences.
Topics: Aging; Androgens; Animals; Castration; Dose-Response Relationship, Drug; Estradiol; Female; Flutamid | 1982 |
Response of rat ventral prostate to a new and novel 5 alpha-reductase inhibitor.
Topics: 5-alpha Reductase Inhibitors; Aging; Androgens; Animals; Azasteroids; Castration; Dihydrotestosteron | 1981 |
Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus.
Topics: Aging; Androgen Receptor Antagonists; Animals; Flutamide; Hippocampus; Hormones; Male; Orchiectomy; | 1995 |
Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback.
Topics: Adult; Aged; Aging; Androgen Receptor Antagonists; Androgens; Estradiol; Feedback; Flutamide; Gonado | 1994 |
Follicle-stimulating hormone and luteinizing hormone secretion in male rats orchidectomized or injected with ethylene dimethane sulfonate.
Topics: Aging; Animals; Animals, Newborn; Chorionic Gonadotropin; Estradiol; Flutamide; Follicle Stimulating | 1993 |
Estrogen, but not androgens, regulates androgen receptor messenger ribonucleic acid expression in the developing male rat forebrain.
Topics: Aging; Androgens; Animals; Animals, Newborn; Diethylstilbestrol; Dihydrotestosterone; Female; Flutam | 1999 |
Mechanisms of reduced body growth in the pubertal feminized male rat: unbalanced estrogen and androgen action on the somatotropic axis.
Topics: Aging; Androgen Receptor Antagonists; Animals; Flutamide; Gene Expression Regulation; Growth Hormone | 2000 |
Testosterone and estradiol differentially regulate TSH-induced thyrocyte proliferation in immature and adult rats.
Topics: Aging; Animals; Cell Division; Estradiol; Estrogen Antagonists; Female; Flutamide; In Vitro Techniqu | 2002 |
Effect of testosterone, sex and age on experimentally induced arterial thrombosis.
Topics: Aging; Animals; Disease Models, Animal; Estradiol; Female; Flutamide; Male; Rabbits; Rats; Sex; Test | 1976 |
Castration and antisteroid treatment impair vocal learning in male zebra finches.
Topics: Aging; Androgen Antagonists; Animals; Birds; Estrogen Antagonists; Female; Flutamide; Learning; Male | 1992 |
Androgens do not regulate the growth hormone response to GHRH in elderly men.
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Buserelin; Flutamide; Goserelin; Growth | 1989 |
Effect of flutamide, a nonsteroidal antiandrogen on testis and accessory genital organs of male rats: a reevaluation in prepubertal and adult rat.
Topics: Aging; Anilides; Animals; Flutamide; Genitalia, Male; Male; Rats; Rats, Inbred Strains; Sexual Matur | 1987 |