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flutamide and Aging

flutamide has been researched along with Aging in 30 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The objective of this study was to treat aging (7-8 months) +/- follicle-stimulating hormone receptor mice that are destined for reproductive failure with 2 selected antiandrogens, curcumin and flutamide, to counteract deleterious effects of mild hyperandrogenemia on the ovary and metabolism."7.75Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice. ( Ram Sairam, M; Tiwari-Pandey, R, 2009)
"To investigate the responsiveness of the healthy aging male hypothalamo-pituitary-gonadal axis to short term interruption of androgen negative feedback, we administered a selective nonsteroidal competitive antagonist of the androgen receptor, flutamide hydrochloride (250 mg, orally, three times daily for 3."3.69Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback. ( Dufau, ML; Urban, RJ; Veldhuis, JD, 1994)
"Flutamide (Flu) is an anti-androgenic compound that disrupts development of male androgen-dependent tissues."1.32Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes. ( Anahara, R; Mori, C; Toyama, Y, 2004)
"Flutamide treatment resulted in a reduced size of two forebrain nuclei that are known to play some role unique to early phases of song learning [lateral magnocellular nucleus of the anterior neostriatum (IMAN) and area X (X)], but did not affect the size of two song-control nuclei that are necessary for normal song production in adult birds [caudal nucleus of the ventral hyperstriatum (HVc) and robust nucleus of the archistriatum (RA)]."1.28Castration and antisteroid treatment impair vocal learning in male zebra finches. ( Bottjer, SW; Hewer, SJ, 1992)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19907 (23.33)18.7374
1990's5 (16.67)18.2507
2000's12 (40.00)29.6817
2010's6 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Campos, SG2
Gonçalves, BF2
Scarano, WR2
Góes, RM2
Taboga, SR2
Takahashi, PY1
Liu, PY1
Veldhuis, JD2
Hsu, SC1
Huang, SM1
Lin, SH1
Ka, SM1
Chen, A1
Shih, MF1
Hsu, YJ1
Legacki, E1
Conley, AJ1
Nitta-Oda, BJ1
Berger, T1
Jian-xin, J1
Cheng-li, C1
Song, W1
Yan, XS1
Huo, DS1
Wang, H1
Yang, ZJ1
Cheng, J1
Hu, W1
Toung, TJ1
Zhang, Z1
Parker, SM1
Roselli, CE1
Hurn, PD1
Tiwari-Pandey, R1
Ram Sairam, M1
Corradi, LS1
Santos, FC1
Custodio, AM1
Vilamaior, PS1
Montalvo, L1
Sánchez-Chapado, M1
Prieto, JC1
Carmena, MJ1
Fisher, JS1
Pastor-Soler, N1
Sharpe, RM1
Breton, S1
Hwang, DY1
Cho, JS1
Chae, KR1
Kang, TS1
Hwang, JH1
Lim, CH1
Lee, SH1
Lim, HJ1
Min, SH1
Sheen, YY1
Jang, IS1
Kim, YK1
Hotchkiss, AK1
Ostby, JS1
Vandenbergh, JG1
Gray, LE1
Anahara, R1
Toyama, Y1
Mori, C1
Magnaghi, V1
Ballabio, M1
Gonzalez, LC1
Leonelli, E1
Motta, M1
Melcangi, RC1
Maire, M1
Florin, A1
Kaszas, K1
Regnier, D1
Contard, P1
Tabone, E1
Mauduit, C1
Bars, R1
Benahmed, M1
de Zegher, F1
Ibáñez, L1
Breedlove, SM1
Arnold, AP1
Kloss, MW1
Rosen, GM1
Rauckman, EJ1
Padilla, GM1
Gladue, BA1
Clemens, LG1
Brooks, JR1
Baptista, EM1
Berman, C1
Ham, EA1
Hichens, M1
Johnston, DB1
Primka, RL1
Rasmusson, GH1
Reynolds, GF1
Schmitt, SM1
Arth, GE1
Kerr, JE1
Allore, RJ1
Beck, SG1
Handa, RJ1
Urban, RJ1
Dufau, ML1
Tena-Sempere, M1
Pinilla, L1
Aguilar, E1
McAbee, MD1
Doncarlos, LL1
Pazos, F1
Sánchez-Franco, F1
Balsa, JA1
Escalada, J1
Palacios, N1
Cacicedo, L1
Banu, SK1
Govindarajulu, P1
Aruldhas, MM1
Uzunova, A1
Ramey, E1
Ramwell, PW1
Bottjer, SW1
Hewer, SJ1
Ceda, GP1
Ceresini, G1
Denti, L1
Cortellini, P1
Hoffman, AR1
Valenti, G1
Dhar, JD1
Setty, BS1

Trials

1 trial available for flutamide and Aging

ArticleYear
Distinct roles of age and abdominal visceral fat in reducing androgen receptor-dependent negative feedback on LH secretion in healthy men.
    Andrology, 2014, Volume: 2, Issue:4

    Topics: Adult; Aged; Aging; Androgen Antagonists; Cross-Over Studies; Double-Blind Method; Feedback; Flutami

2014

Other Studies

29 other studies available for flutamide and Aging

ArticleYear
Phenotypic and metabolic aspects of prostatic epithelial cells in aged gerbils after antisteroidal therapy: turnover in the state of chromatin condensation and androgen-independent cell replacement.
    Acta histochemica, 2014, Volume: 116, Issue:1

    Topics: Aging; Androgen Antagonists; Androgens; Animals; Cell Proliferation; Chromatin Assembly and Disassem

2014
Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway.
    The Biochemical journal, 2014, Dec-01, Volume: 464, Issue:2

    Topics: Aging; Animals; Estrogens; Flutamide; Gene Expression Regulation; Glucuronidase; Kidney; Klotho Prot

2014
Porcine sertoli cell proliferation after androgen receptor inactivation.
    Biology of reproduction, 2015, Volume: 92, Issue:4

    Topics: Aging; Androgen Receptor Antagonists; Animals; Cell Proliferation; Flutamide; Gene Expression; Gonad

2015
Effects of Testosterone Treatment on Synaptic Plasticity and Behavior in Senescence Accelerated Mice.
    Journal of toxicology and environmental health. Part A, 2015, Volume: 78, Issue:21-22

    Topics: Aging; Androgen Antagonists; Androgens; Animals; Behavior, Animal; Cognition; Cyclic AMP Response El

2015
Age-dependent effects of testosterone in experimental stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:3

    Topics: Aging; Androgen Antagonists; Animals; Aromatase; Castration; Flutamide; Infarction, Middle Cerebral

2009
Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice.
    Reproductive sciences (Thousand Oaks, Calif.), 2009, Volume: 16, Issue:6

    Topics: Abdominal Fat; Aging; Animals; Curcumin; Female; Flutamide; Haploidy; Mice; Mice, Transgenic; Obesit

2009
Tissue changes in senescent gerbil prostate after hormone deprivation leads to acquisition of androgen insensitivity.
    International journal of experimental pathology, 2010, Volume: 91, Issue:5

    Topics: Aging; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Apoptosis; Body We

2010
Regulation of the expression of protein kinase C isoenzymes in rat ventral prostate: effects of age, castration and flutamide treatment.
    Life sciences, 2002, Sep-27, Volume: 71, Issue:19

    Topics: Aging; Androgen Antagonists; Animals; Blotting, Western; Flutamide; Injections, Subcutaneous; Isoenz

2002
Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis.
    Biology of reproduction, 2002, Volume: 67, Issue:4

    Topics: Aging; Androgen Antagonists; Animals; Animals, Newborn; Blotting, Western; Cell Count; Diethylstilbe

2002
Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens.
    Archives of biochemistry and biophysics, 2003, Jul-15, Volume: 415, Issue:2

    Topics: Aging; Androgen Antagonists; Androgens; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP

2003
An environmental antiandrogen, vinclozolin, alters the organization of play behavior.
    Physiology & behavior, 2003, Volume: 79, Issue:2

    Topics: Aging; Androgen Antagonists; Animals; Animals, Newborn; Behavior, Animal; Female; Flutamide; Fungici

2003
Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes.
    Reproductive toxicology (Elmsford, N.Y.), 2004, Volume: 18, Issue:4

    Topics: Acrosome; Aging; Androgen Antagonists; Animals; Animals, Newborn; Cell Nucleus; Flutamide; Male; Mic

2004
The synthesis of glycoprotein Po and peripheral myelin protein 22 in sciatic nerve of male rats is modulated by testosterone metabolites.
    Brain research. Molecular brain research, 2004, Jul-05, Volume: 126, Issue:1

    Topics: Aging; Androgen Antagonists; Animals; Flutamide; Male; Myelin P0 Protein; Myelin Proteins; Orchiecto

2004
Alteration of transforming growth factor-beta signaling system expression in adult rat germ cells with a chronic apoptotic cell death process after fetal androgen disruption.
    Endocrinology, 2005, Volume: 146, Issue:12

    Topics: Aging; Androgen Antagonists; Animals; Apoptosis; Dose-Response Relationship, Drug; Fas Ligand Protei

2005
Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.
    Fertility and sterility, 2006, Volume: 86 Suppl 1

    Topics: Aging; Androgen Antagonists; Body Weight; Child; Drug Therapy, Combination; Female; Fetal Developmen

2006
Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1983, Volume: 3, Issue:2

    Topics: Aging; Anilides; Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Muscle Development; Neur

1983
Androgenic suppression of mouse hepatic FAD-containing monooxygenase activity.
    Life sciences, 1982, Sep-06, Volume: 31, Issue:10

    Topics: Aging; Animals; Castration; Female; Flutamide; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Mi

1982
Development of feminine sexual behavior in the rat: androgenic and temporal influences.
    Physiology & behavior, 1982, Volume: 29, Issue:2

    Topics: Aging; Androgens; Animals; Castration; Dose-Response Relationship, Drug; Estradiol; Female; Flutamid

1982
Response of rat ventral prostate to a new and novel 5 alpha-reductase inhibitor.
    Endocrinology, 1981, Volume: 109, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Aging; Androgens; Animals; Azasteroids; Castration; Dihydrotestosteron

1981
Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus.
    Endocrinology, 1995, Volume: 136, Issue:8

    Topics: Aging; Androgen Receptor Antagonists; Animals; Flutamide; Hippocampus; Hormones; Male; Orchiectomy;

1995
Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:6

    Topics: Adult; Aged; Aging; Androgen Receptor Antagonists; Androgens; Estradiol; Feedback; Flutamide; Gonado

1994
Follicle-stimulating hormone and luteinizing hormone secretion in male rats orchidectomized or injected with ethylene dimethane sulfonate.
    Endocrinology, 1993, Volume: 133, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Chorionic Gonadotropin; Estradiol; Flutamide; Follicle Stimulating

1993
Estrogen, but not androgens, regulates androgen receptor messenger ribonucleic acid expression in the developing male rat forebrain.
    Endocrinology, 1999, Volume: 140, Issue:8

    Topics: Aging; Androgens; Animals; Animals, Newborn; Diethylstilbestrol; Dihydrotestosterone; Female; Flutam

1999
Mechanisms of reduced body growth in the pubertal feminized male rat: unbalanced estrogen and androgen action on the somatotropic axis.
    Pediatric research, 2000, Volume: 48, Issue:1

    Topics: Aging; Androgen Receptor Antagonists; Animals; Flutamide; Gene Expression Regulation; Growth Hormone

2000
Testosterone and estradiol differentially regulate TSH-induced thyrocyte proliferation in immature and adult rats.
    Steroids, 2002, Volume: 67, Issue:7

    Topics: Aging; Animals; Cell Division; Estradiol; Estrogen Antagonists; Female; Flutamide; In Vitro Techniqu

2002
Effect of testosterone, sex and age on experimentally induced arterial thrombosis.
    Nature, 1976, Jun-24, Volume: 261, Issue:5562

    Topics: Aging; Animals; Disease Models, Animal; Estradiol; Female; Flutamide; Male; Rabbits; Rats; Sex; Test

1976
Castration and antisteroid treatment impair vocal learning in male zebra finches.
    Journal of neurobiology, 1992, Volume: 23, Issue:4

    Topics: Aging; Androgen Antagonists; Animals; Birds; Estrogen Antagonists; Female; Flutamide; Learning; Male

1992
Androgens do not regulate the growth hormone response to GHRH in elderly men.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:12

    Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Buserelin; Flutamide; Goserelin; Growth

1989
Effect of flutamide, a nonsteroidal antiandrogen on testis and accessory genital organs of male rats: a reevaluation in prepubertal and adult rat.
    Indian journal of experimental biology, 1987, Volume: 25, Issue:2

    Topics: Aging; Anilides; Animals; Flutamide; Genitalia, Male; Male; Rats; Rats, Inbred Strains; Sexual Matur

1987