flutamide has been researched along with Aging in 30 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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" The objective of this study was to treat aging (7-8 months) +/- follicle-stimulating hormone receptor mice that are destined for reproductive failure with 2 selected antiandrogens, curcumin and flutamide, to counteract deleterious effects of mild hyperandrogenemia on the ovary and metabolism." | 7.75 | Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice. ( Ram Sairam, M; Tiwari-Pandey, R, 2009) |
"To investigate the responsiveness of the healthy aging male hypothalamo-pituitary-gonadal axis to short term interruption of androgen negative feedback, we administered a selective nonsteroidal competitive antagonist of the androgen receptor, flutamide hydrochloride (250 mg, orally, three times daily for 3." | 3.69 | Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback. ( Dufau, ML; Urban, RJ; Veldhuis, JD, 1994) |
"Flutamide (Flu) is an anti-androgenic compound that disrupts development of male androgen-dependent tissues." | 1.32 | Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes. ( Anahara, R; Mori, C; Toyama, Y, 2004) |
"Flutamide treatment resulted in a reduced size of two forebrain nuclei that are known to play some role unique to early phases of song learning [lateral magnocellular nucleus of the anterior neostriatum (IMAN) and area X (X)], but did not affect the size of two song-control nuclei that are necessary for normal song production in adult birds [caudal nucleus of the ventral hyperstriatum (HVc) and robust nucleus of the archistriatum (RA)]." | 1.28 | Castration and antisteroid treatment impair vocal learning in male zebra finches. ( Bottjer, SW; Hewer, SJ, 1992) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (23.33) | 18.7374 |
1990's | 5 (16.67) | 18.2507 |
2000's | 12 (40.00) | 29.6817 |
2010's | 6 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Campos, SG | 2 |
Gonçalves, BF | 2 |
Scarano, WR | 2 |
Góes, RM | 2 |
Taboga, SR | 2 |
Takahashi, PY | 1 |
Liu, PY | 1 |
Veldhuis, JD | 2 |
Hsu, SC | 1 |
Huang, SM | 1 |
Lin, SH | 1 |
Ka, SM | 1 |
Chen, A | 1 |
Shih, MF | 1 |
Hsu, YJ | 1 |
Legacki, E | 1 |
Conley, AJ | 1 |
Nitta-Oda, BJ | 1 |
Berger, T | 1 |
Jian-xin, J | 1 |
Cheng-li, C | 1 |
Song, W | 1 |
Yan, XS | 1 |
Huo, DS | 1 |
Wang, H | 1 |
Yang, ZJ | 1 |
Cheng, J | 1 |
Hu, W | 1 |
Toung, TJ | 1 |
Zhang, Z | 1 |
Parker, SM | 1 |
Roselli, CE | 1 |
Hurn, PD | 1 |
Tiwari-Pandey, R | 1 |
Ram Sairam, M | 1 |
Corradi, LS | 1 |
Santos, FC | 1 |
Custodio, AM | 1 |
Vilamaior, PS | 1 |
Montalvo, L | 1 |
Sánchez-Chapado, M | 1 |
Prieto, JC | 1 |
Carmena, MJ | 1 |
Fisher, JS | 1 |
Pastor-Soler, N | 1 |
Sharpe, RM | 1 |
Breton, S | 1 |
Hwang, DY | 1 |
Cho, JS | 1 |
Chae, KR | 1 |
Kang, TS | 1 |
Hwang, JH | 1 |
Lim, CH | 1 |
Lee, SH | 1 |
Lim, HJ | 1 |
Min, SH | 1 |
Sheen, YY | 1 |
Jang, IS | 1 |
Kim, YK | 1 |
Hotchkiss, AK | 1 |
Ostby, JS | 1 |
Vandenbergh, JG | 1 |
Gray, LE | 1 |
Anahara, R | 1 |
Toyama, Y | 1 |
Mori, C | 1 |
Magnaghi, V | 1 |
Ballabio, M | 1 |
Gonzalez, LC | 1 |
Leonelli, E | 1 |
Motta, M | 1 |
Melcangi, RC | 1 |
Maire, M | 1 |
Florin, A | 1 |
Kaszas, K | 1 |
Regnier, D | 1 |
Contard, P | 1 |
Tabone, E | 1 |
Mauduit, C | 1 |
Bars, R | 1 |
Benahmed, M | 1 |
de Zegher, F | 1 |
Ibáñez, L | 1 |
Breedlove, SM | 1 |
Arnold, AP | 1 |
Kloss, MW | 1 |
Rosen, GM | 1 |
Rauckman, EJ | 1 |
Padilla, GM | 1 |
Gladue, BA | 1 |
Clemens, LG | 1 |
Brooks, JR | 1 |
Baptista, EM | 1 |
Berman, C | 1 |
Ham, EA | 1 |
Hichens, M | 1 |
Johnston, DB | 1 |
Primka, RL | 1 |
Rasmusson, GH | 1 |
Reynolds, GF | 1 |
Schmitt, SM | 1 |
Arth, GE | 1 |
Kerr, JE | 1 |
Allore, RJ | 1 |
Beck, SG | 1 |
Handa, RJ | 1 |
Urban, RJ | 1 |
Dufau, ML | 1 |
Tena-Sempere, M | 1 |
Pinilla, L | 1 |
Aguilar, E | 1 |
McAbee, MD | 1 |
Doncarlos, LL | 1 |
Pazos, F | 1 |
Sánchez-Franco, F | 1 |
Balsa, JA | 1 |
Escalada, J | 1 |
Palacios, N | 1 |
Cacicedo, L | 1 |
Banu, SK | 1 |
Govindarajulu, P | 1 |
Aruldhas, MM | 1 |
Uzunova, A | 1 |
Ramey, E | 1 |
Ramwell, PW | 1 |
Bottjer, SW | 1 |
Hewer, SJ | 1 |
Ceda, GP | 1 |
Ceresini, G | 1 |
Denti, L | 1 |
Cortellini, P | 1 |
Hoffman, AR | 1 |
Valenti, G | 1 |
Dhar, JD | 1 |
Setty, BS | 1 |
1 trial available for flutamide and Aging
Article | Year |
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Distinct roles of age and abdominal visceral fat in reducing androgen receptor-dependent negative feedback on LH secretion in healthy men.
Topics: Adult; Aged; Aging; Androgen Antagonists; Cross-Over Studies; Double-Blind Method; Feedback; Flutami | 2014 |
29 other studies available for flutamide and Aging
Article | Year |
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Phenotypic and metabolic aspects of prostatic epithelial cells in aged gerbils after antisteroidal therapy: turnover in the state of chromatin condensation and androgen-independent cell replacement.
Topics: Aging; Androgen Antagonists; Androgens; Animals; Cell Proliferation; Chromatin Assembly and Disassem | 2014 |
Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway.
Topics: Aging; Animals; Estrogens; Flutamide; Gene Expression Regulation; Glucuronidase; Kidney; Klotho Prot | 2014 |
Porcine sertoli cell proliferation after androgen receptor inactivation.
Topics: Aging; Androgen Receptor Antagonists; Animals; Cell Proliferation; Flutamide; Gene Expression; Gonad | 2015 |
Effects of Testosterone Treatment on Synaptic Plasticity and Behavior in Senescence Accelerated Mice.
Topics: Aging; Androgen Antagonists; Androgens; Animals; Behavior, Animal; Cognition; Cyclic AMP Response El | 2015 |
Age-dependent effects of testosterone in experimental stroke.
Topics: Aging; Androgen Antagonists; Animals; Aromatase; Castration; Flutamide; Infarction, Middle Cerebral | 2009 |
Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice.
Topics: Abdominal Fat; Aging; Animals; Curcumin; Female; Flutamide; Haploidy; Mice; Mice, Transgenic; Obesit | 2009 |
Tissue changes in senescent gerbil prostate after hormone deprivation leads to acquisition of androgen insensitivity.
Topics: Aging; Androgen Antagonists; Androgen-Insensitivity Syndrome; Androgens; Animals; Apoptosis; Body We | 2010 |
Regulation of the expression of protein kinase C isoenzymes in rat ventral prostate: effects of age, castration and flutamide treatment.
Topics: Aging; Androgen Antagonists; Animals; Blotting, Western; Flutamide; Injections, Subcutaneous; Isoenz | 2002 |
Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis.
Topics: Aging; Androgen Antagonists; Animals; Animals, Newborn; Blotting, Western; Cell Count; Diethylstilbe | 2002 |
Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens.
Topics: Aging; Androgen Antagonists; Androgens; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP | 2003 |
An environmental antiandrogen, vinclozolin, alters the organization of play behavior.
Topics: Aging; Androgen Antagonists; Animals; Animals, Newborn; Behavior, Animal; Female; Flutamide; Fungici | 2003 |
Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes.
Topics: Acrosome; Aging; Androgen Antagonists; Animals; Animals, Newborn; Cell Nucleus; Flutamide; Male; Mic | 2004 |
The synthesis of glycoprotein Po and peripheral myelin protein 22 in sciatic nerve of male rats is modulated by testosterone metabolites.
Topics: Aging; Androgen Antagonists; Animals; Flutamide; Male; Myelin P0 Protein; Myelin Proteins; Orchiecto | 2004 |
Alteration of transforming growth factor-beta signaling system expression in adult rat germ cells with a chronic apoptotic cell death process after fetal androgen disruption.
Topics: Aging; Androgen Antagonists; Animals; Apoptosis; Dose-Response Relationship, Drug; Fas Ligand Protei | 2005 |
Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.
Topics: Aging; Androgen Antagonists; Body Weight; Child; Drug Therapy, Combination; Female; Fetal Developmen | 2006 |
Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide.
Topics: Aging; Anilides; Animals; Female; Flutamide; Male; Maternal-Fetal Exchange; Muscle Development; Neur | 1983 |
Androgenic suppression of mouse hepatic FAD-containing monooxygenase activity.
Topics: Aging; Animals; Castration; Female; Flutamide; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Mi | 1982 |
Development of feminine sexual behavior in the rat: androgenic and temporal influences.
Topics: Aging; Androgens; Animals; Castration; Dose-Response Relationship, Drug; Estradiol; Female; Flutamid | 1982 |
Response of rat ventral prostate to a new and novel 5 alpha-reductase inhibitor.
Topics: 5-alpha Reductase Inhibitors; Aging; Androgens; Animals; Azasteroids; Castration; Dihydrotestosteron | 1981 |
Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus.
Topics: Aging; Androgen Receptor Antagonists; Animals; Flutamide; Hippocampus; Hormones; Male; Orchiectomy; | 1995 |
Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback.
Topics: Adult; Aged; Aging; Androgen Receptor Antagonists; Androgens; Estradiol; Feedback; Flutamide; Gonado | 1994 |
Follicle-stimulating hormone and luteinizing hormone secretion in male rats orchidectomized or injected with ethylene dimethane sulfonate.
Topics: Aging; Animals; Animals, Newborn; Chorionic Gonadotropin; Estradiol; Flutamide; Follicle Stimulating | 1993 |
Estrogen, but not androgens, regulates androgen receptor messenger ribonucleic acid expression in the developing male rat forebrain.
Topics: Aging; Androgens; Animals; Animals, Newborn; Diethylstilbestrol; Dihydrotestosterone; Female; Flutam | 1999 |
Mechanisms of reduced body growth in the pubertal feminized male rat: unbalanced estrogen and androgen action on the somatotropic axis.
Topics: Aging; Androgen Receptor Antagonists; Animals; Flutamide; Gene Expression Regulation; Growth Hormone | 2000 |
Testosterone and estradiol differentially regulate TSH-induced thyrocyte proliferation in immature and adult rats.
Topics: Aging; Animals; Cell Division; Estradiol; Estrogen Antagonists; Female; Flutamide; In Vitro Techniqu | 2002 |
Effect of testosterone, sex and age on experimentally induced arterial thrombosis.
Topics: Aging; Animals; Disease Models, Animal; Estradiol; Female; Flutamide; Male; Rabbits; Rats; Sex; Test | 1976 |
Castration and antisteroid treatment impair vocal learning in male zebra finches.
Topics: Aging; Androgen Antagonists; Animals; Birds; Estrogen Antagonists; Female; Flutamide; Learning; Male | 1992 |
Androgens do not regulate the growth hormone response to GHRH in elderly men.
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Buserelin; Flutamide; Goserelin; Growth | 1989 |
Effect of flutamide, a nonsteroidal antiandrogen on testis and accessory genital organs of male rats: a reevaluation in prepubertal and adult rat.
Topics: Aging; Anilides; Animals; Flutamide; Genitalia, Male; Male; Rats; Rats, Inbred Strains; Sexual Matur | 1987 |