flutamide has been researched along with Abdominal Cryptorchidism in 43 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Female Sprague-Dawley rats were administrated flutamide during late pregnancy to induce a model of cryptorchidism in male offspring." | 7.91 | Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Peng, J; Shen, L; Tao, X; Timashev, P; Wei, G; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2019) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 7.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| " Female Sprague-Dawley rats were administrated flutamide during late pregnancy to induce a model of cryptorchidism in male offspring." | 3.91 | Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. ( He, D; Hu, D; Lin, T; Liu, B; Liu, X; Long, C; Peng, J; Shen, L; Tao, X; Timashev, P; Wei, G; Yu, Y; Zhang, D; Zhang, Y; Zhou, Y, 2019) |
| "Time-mated Sprague-Dawley female rats were injected subcutaneously with flutamide (75 mg/kg in sunflower oil) on days 16 to 19 of pregnancy." | 3.75 | The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development. ( Balic, A; Buraundi, S; Farmer, P; Hutson, J; Nation, T; Newgreen, D; Southwell, B, 2009) |
| "The incidence of hypospadias increased with the dose of flutamide (0, 29." | 3.73 | [Impact of flutamide on sex differentiation in rats]. ( Li, Y; Liang, Y; Wang, WD; Wu, DS; Zhang, H, 2006) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 3.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| "Testicular ectopy, unlike cryptorchidism, was associated with a short gubernacular ligament only." | 1.62 | Morphologic alterations of the genital mesentery implicated in testis non-descent in rats prenatally exposed to flutamide. ( Chrousos, G; Kanaka-Gantenbein, C; Kostakis, A; Mentessidou, A; Mirilas, P; Salakos, C, 2021) |
| "Our results demonstrated cryptorchidism models induced noticeable decreased fertility, significantly reduced sperm count, increased sperm abnormality rate, decreased testosterone and severe testicular damage in histomorphology." | 1.48 | Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy. ( He, DW; Lin, T; Liu, B; Long, CL; Shen, LJ; Tang, XL; Wei, GH; Wei, Y; Wu, SD; Zhou, Y, 2018) |
| "Cryptorchidism affects 2-4% of newborn boys." | 1.40 | Molecular signals governing cremaster muscle development: clues for cryptorchidism. ( Hutson, JM; Li, R; Southwell, B; Szarek, M; Vikraman, J, 2014) |
| "No cryptorchidism was found in group A; unilateral cryptorchidism was seen in groups B (10." | 1.39 | [Expression of insulin-like factor 3 in the testis of flutamide-induced cryptorchidism mice and its significance]. ( Bai, C; Yuan, YM; Zhang, C; Zheng, M; Zhou, XJ, 2013) |
| "Flu induced 43." | 1.37 | [Establishment of a rat model of flutamide-induced cryptorchidism with remaining gonocytes]. ( He, DW; He, WF; Ma, C; Wei, GH; Zhang, YB; Zhao, D, 2011) |
| "The incidence of Flu-induced cryptorchidism can be decreased by T3 treatment after birth." | 1.37 | [The regulation of T3 on maldeveloped gonocyte (Go) and expression of NCAM in flutamide-induced cryptorchidism rat]. ( He, DW; He, WF; Jiang, YC; Ma, C; Wei, GH; Zhao, D, 2011) |
| "Flutamide was injected into the abdomen of pregnant rats for 7 days from the 14th to 20th day of gestation." | 1.34 | Influence for testicular development and histological peculiarity in the testes of flutamide-induced cryptorchid rat model. ( Hayashi, Y; Kohri, K; Kojima, Y; Kurokawa, S; Mizuno, K; Sasaki, S, 2007) |
| "In flutamide-treated rats, DNA synthesis was suppressed until day 6, similar suppression was observed in capsaicin-treated SD, and TS rats until day 4." | 1.33 | Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve. ( Bidarkar, SS; Donath, S; Farmer, PJ; Hutson, JM; Ng, SL; Sourial, M, 2005) |
| "Flutamide was administered from day 15 to day 19, cyproterone acetate on day 15 of intra-uterine life." | 1.33 | Anti-androgen induced inhibition of testicular descent is associated with a decrease in sympathetic tonus. ( Ekinci, S; Ertunç, M; Onur, R; Tanyel, FC; Yildirim, M, 2005) |
| "True cryptorchidism occurred in 10% of cases, whereas 50% of testes descended to the scrotum and 40% were located in a suprainguinal ectopic region." | 1.30 | The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat. ( Bennett, NK; Gilmore, DP; Kassim, NM; McDonald, SW; Payne, AP; Reid, O, 1997) |
| "In addition, antiandrogen induced cryptorchidism is associated with epididymal malformation and failure of gubernacular regression." | 1.29 | Antiandrogen induced cryptorchidism in the pig is associated with failed gubernacular regression and epididymal malformations. ( Husmann, DA; Kramer, SA; McMahon, DR, 1995) |
| "The decrease in undescended testes and epididymal abnormalities following epidermal growth factor treatment was significant at p < 0." | 1.29 | Epidermal growth factor reverses antiandrogen induced cryptorchidism and epididymal development. ( Cain, MP; Husmann, DA; Kramer, SA; Tindall, DJ, 1994) |
| "We compared these 2 groups with the testicular feminization mouse with androgen insensitivity." | 1.29 | The relationship among calcitonin gene-related peptide, androgens and gubernacular development in 3 animal models of cryptorchidism. ( Goh, DW; Hutson, JM; Middlesworth, W; Momose, Y, 1993) |
| "Cryptorchidism was enhanced when rats were treated postnatally with testosterone or oestradiol." | 1.28 | Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide. ( van der Schoot, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (39.53) | 18.2507 |
| 2000's | 13 (30.23) | 29.6817 |
| 2010's | 10 (23.26) | 24.3611 |
| 2020's | 3 (6.98) | 2.80 |
| Authors | Studies |
|---|---|
| Kemahli, E | 1 |
| Uyeturk, U | 2 |
| Cetinkaya, A | 1 |
| Erimsah, S | 1 |
| Gucuk, A | 1 |
| Schreiber, E | 1 |
| Garcia, T | 1 |
| González, N | 1 |
| Esplugas, R | 1 |
| Sharma, RP | 1 |
| Torrente, M | 1 |
| Kumar, V | 1 |
| Bovee, T | 1 |
| Katsanou, ES | 1 |
| Machera, K | 1 |
| Domingo, JL | 1 |
| Gómez, M | 1 |
| Mentessidou, A | 1 |
| Salakos, C | 1 |
| Chrousos, G | 1 |
| Kanaka-Gantenbein, C | 1 |
| Kostakis, A | 1 |
| Mirilas, P | 1 |
| Wei, Y | 1 |
| Zhou, Y | 2 |
| Tang, XL | 1 |
| Liu, B | 2 |
| Shen, LJ | 1 |
| Long, CL | 1 |
| Lin, T | 2 |
| He, DW | 3 |
| Wu, SD | 1 |
| Wei, GH | 3 |
| Zhang, D | 1 |
| Hu, D | 1 |
| Peng, J | 1 |
| Shen, L | 1 |
| Long, C | 1 |
| Yu, Y | 1 |
| Zhang, Y | 1 |
| Liu, X | 1 |
| Tao, X | 1 |
| Timashev, P | 1 |
| He, D | 1 |
| Wei, G | 1 |
| Yuan, YM | 1 |
| Zhang, C | 1 |
| Bai, C | 1 |
| Zheng, M | 1 |
| Zhou, XJ | 1 |
| Szarek, M | 1 |
| Li, R | 1 |
| Vikraman, J | 1 |
| Southwell, B | 2 |
| Hutson, JM | 11 |
| Kassim, NM | 2 |
| Russell, DA | 1 |
| Payne, AP | 2 |
| Nation, T | 1 |
| Balic, A | 3 |
| Buraundi, S | 3 |
| Farmer, P | 2 |
| Newgreen, D | 2 |
| Hutson, J | 1 |
| Kim, TS | 1 |
| Jung, KK | 1 |
| Kim, SS | 1 |
| Kang, IH | 1 |
| Baek, JH | 1 |
| Nam, HS | 1 |
| Hong, SK | 1 |
| Lee, BM | 1 |
| Hong, JT | 1 |
| Oh, KW | 1 |
| Kim, HS | 1 |
| Han, SY | 1 |
| Kang, TS | 1 |
| Ma, C | 2 |
| Zhao, D | 2 |
| He, WF | 2 |
| Zhang, YB | 1 |
| Jiang, YC | 1 |
| Nation, TR | 1 |
| Farmer, PJ | 5 |
| Southwell, BR | 3 |
| Chen, N | 1 |
| Harisis, GN | 1 |
| Sourial, M | 3 |
| Tobe, T | 1 |
| Toyota, N | 1 |
| Matsuno, Y | 1 |
| Komiyama, M | 1 |
| Adachi, T | 1 |
| Ito, H | 1 |
| Mori, C | 1 |
| Goto, K | 1 |
| Koizumi, K | 1 |
| Takaori, H | 1 |
| Fujii, Y | 1 |
| Furuyama, Y | 1 |
| Saika, O | 1 |
| Suzuki, H | 1 |
| Saito, K | 1 |
| Suzuki, K | 1 |
| Ng, SL | 1 |
| Bidarkar, SS | 1 |
| Donath, S | 1 |
| Foster, PM | 2 |
| Harris, MW | 1 |
| Tanyel, FC | 1 |
| Ertunç, M | 1 |
| Ekinci, S | 1 |
| Yildirim, M | 1 |
| Onur, R | 1 |
| Veeramachaneni, DN | 1 |
| Li, Y | 1 |
| Zhang, H | 1 |
| Wang, WD | 1 |
| Liang, Y | 1 |
| Wu, DS | 1 |
| Mizuno, K | 1 |
| Hayashi, Y | 1 |
| Kojima, Y | 1 |
| Kurokawa, S | 1 |
| Sasaki, S | 1 |
| Kohri, K | 1 |
| Harnaen, EJ | 1 |
| Na, AF | 1 |
| Shenker, NS | 1 |
| Cain, MP | 4 |
| Kramer, SA | 5 |
| Tindall, DJ | 4 |
| Husmann, DA | 8 |
| McMahon, DR | 1 |
| Boone, TB | 1 |
| McPhaul, MJ | 3 |
| Shono, T | 5 |
| Goh, DW | 4 |
| Middlesworth, W | 2 |
| Ramm-Anderson, S | 2 |
| Momose, Y | 2 |
| Watts, L | 1 |
| Middlesworth, B | 1 |
| Zhou, B | 1 |
| McDonald, SW | 1 |
| Reid, O | 1 |
| Bennett, NK | 1 |
| Gilmore, DP | 1 |
| Mylchreest, E | 1 |
| Sar, M | 1 |
| Cattley, RC | 1 |
| Hrabovszky, Z | 1 |
| Zakaria, O | 2 |
| Imajima, T | 2 |
| Suita, S | 2 |
| Kai, H | 1 |
| van der Schoot, P | 1 |
| Spencer, JR | 1 |
| Torrado, T | 1 |
| Sanchez, RS | 1 |
| Vaughan, ED | 1 |
| Imperato-McGinley, J | 1 |
43 other studies available for flutamide and Abdominal Cryptorchidism
| Article | Year |
|---|---|
Protective Effects of N-Acetyl Cysteine on Undescended Testis after Orchiopexy: A Rat-model Study.
Topics: Acetylcysteine; Animals; Antioxidants; Cryptorchidism; Female; Flutamide; Humans; Male; Orchiopexy; | 2023 |
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring.
Topics: Animals; Animals, Newborn; Cryptorchidism; Dienestrol; Dose-Response Relationship, Drug; Endpoint De | 2020 |
Morphologic alterations of the genital mesentery implicated in testis non-descent in rats prenatally exposed to flutamide.
Topics: Androgens; Animals; Cryptorchidism; Female; Flutamide; Genitalia, Male; Male; Mesentery; Pregnancy; | 2021 |
Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy.
Topics: Androgen Antagonists; Animals; Apoptosis; Autophagosomes; Autophagy; Biomarkers; Cryptorchidism; Die | 2018 |
Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro.
Topics: Androgen Antagonists; Animals; Blood-Testis Barrier; Connexins; Cryptorchidism; Female; Flutamide; I | 2019 |
[Expression of insulin-like factor 3 in the testis of flutamide-induced cryptorchidism mice and its significance].
Topics: Animals; Cryptorchidism; Female; Flutamide; Insulin; Male; Maternal Exposure; Mice; Mice, Inbred BAL | 2013 |
Molecular signals governing cremaster muscle development: clues for cryptorchidism.
Topics: Animals; Animals, Newborn; beta Catenin; Cryptorchidism; Flutamide; Immunohistochemistry; Ligaments; | 2014 |
Does the cranial suspensory ligament have a role in cryptorchidism?
Topics: Animals; Cryptorchidism; Flutamide; Gonads; Male; Microscopy, Acoustic; Rats; Testis | 2010 |
The antiandrogen flutamide perturbs inguinoscrotal testicular descent in the rat and suggests a link with mammary development.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Cell Division; Cell Movement; Cryptorchidism; Disea | 2009 |
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
[Establishment of a rat model of flutamide-induced cryptorchidism with remaining gonocytes].
Topics: Animals; Cryptorchidism; Female; Flutamide; Male; Neural Cell Adhesion Molecules; Pregnancy; Rats; R | 2011 |
[The regulation of T3 on maldeveloped gonocyte (Go) and expression of NCAM in flutamide-induced cryptorchidism rat].
Topics: Animals; Cryptorchidism; Flutamide; Male; Neural Cell Adhesion Molecules; Rats; Rats, Sprague-Dawley | 2011 |
The effect of flutamide on expression of androgen and estrogen receptors in the gubernaculum and surrounding structures during testicular descent.
Topics: Androgen Antagonists; Animals; Cell Nucleus; Cryptorchidism; Estrogen Receptor alpha; Estrogen Recep | 2011 |
Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.
Topics: Adaptor Proteins, Signal Transducing; Androgen Antagonists; Androgens; Animals; beta Catenin; Carrie | 2011 |
Embryonic myosin heavy chain and troponin T isoforms remain in the cremaster muscle of adult rat cryptorchidism induced with flutamide.
Topics: Age Factors; Androgen Antagonists; Animals; Antibodies, Monoclonal; Cryptorchidism; Female; Flutamid | 2002 |
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation | 2004 |
Gubernacular cell division in different rodent models of cryptorchidism supports indirect androgenic action via the genitofemoral nerve.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Calcitonin Gene-Re | 2005 |
Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages.
Topics: Androgen Antagonists; Androgens; Animals; Cryptorchidism; Epididymis; Female; Flutamide; Genitalia, | 2005 |
Anti-androgen induced inhibition of testicular descent is associated with a decrease in sympathetic tonus.
Topics: Androgen Antagonists; Androgens; Animals; Cryptorchidism; Cyproterone Acetate; Flutamide; Isoprotere | 2005 |
Germ cell atypia in undescended testes hinges on the aetiology of cryptorchidism but not the abdominal location per se.
Topics: Abdomen; Androgen Antagonists; Animals; Carcinoma in Situ; Cryptorchidism; Dichlorodiphenyl Dichloro | 2006 |
[Impact of flutamide on sex differentiation in rats].
Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Hypospadias; Male; Pregnancy; Pren | 2006 |
Influence for testicular development and histological peculiarity in the testes of flutamide-induced cryptorchid rat model.
Topics: Animals; Cryptorchidism; Flutamide; Male; Rats; Rats, Sprague-Dawley; Testis | 2007 |
The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the rat.
Topics: Abdominal Muscles; Animals; Animals, Newborn; Cryptorchidism; Disease Models, Animal; Female; Flutam | 2007 |
Flutamide-induced cryptorchidism in the rat is associated with altered gubernacular morphology.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Gestational Age; Male; Pregnancy; | 1995 |
Antiandrogen induced cryptorchidism in the pig is associated with failed gubernacular regression and epididymal malformations.
Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epididymis; Flutamide; Male; Swine; Testis | 1995 |
Flutamide-induced testicular undescent in the rat is associated with alterations in genitofemoral nerve morphology.
Topics: Age Factors; Animals; Cryptorchidism; Flutamide; Male; Muscles; Nerve Fibers, Myelinated; Rats; Rats | 1994 |
Alterations in maternal epidermal growth factor (EGF) effect testicular descent and epididymal development.
Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epidermal Growth Factor; Epididymis; Female; F | 1994 |
Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats.
Topics: Animals; Capsaicin; Cryptorchidism; Female; Flutamide; Male; Pregnancy; Prenatal Exposure Delayed Ef | 1994 |
Expression of androgen receptor protein within the lumbar spinal cord during ontologic development and following antiandrogen induced cryptorchidism.
Topics: Animals; Cell Count; Cryptorchidism; Female; Flutamide; Immunohistochemistry; Lumbosacral Region; Ma | 1994 |
Epidermal growth factor reverses antiandrogen induced cryptorchidism and epididymal development.
Topics: Abnormalities, Drug-Induced; Animals; Cryptorchidism; Epidermal Growth Factor; Epididymis; Female; F | 1994 |
Prenatal androgen blockade with flutamide inhibits masculinization of the genitofemoral nerve and testicular descent.
Topics: Animals; Calcitonin Gene-Related Peptide; Cryptorchidism; Fetus; Flutamide; Immunohistochemistry; Ma | 1994 |
The effect of flutamide on testicular descent in rats examined by scanning electron microscopy.
Topics: Animals; Cryptorchidism; Fetus; Flutamide; Male; Microscopy, Electron, Scanning; Rats; Rats, Sprague | 1994 |
The relationship among calcitonin gene-related peptide, androgens and gubernacular development in 3 animal models of cryptorchidism.
Topics: Androgen-Insensitivity Syndrome; Androgens; Animals; Calcitonin Gene-Related Peptide; Cryptorchidism | 1993 |
Scanning electron microscopy shows inhibited gubernacular development in relation to undescended testes in oestrogen-treated mice.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Embryo, Mammalian; Estrogens; Female; Flutamide; Male | 1996 |
The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Feminization; Flutamide; Gestational Age; Male; Rats; | 1997 |
Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Cryptorchid | 1999 |
Does the sensory nucleus of the genitofemoral nerve have a role in testicular descent?
Topics: Androgen Antagonists; Androgens; Animals; Calcitonin Gene-Related Peptide; Cryptorchidism; Female; F | 2000 |
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism.
Topics: Androgen Antagonists; Animals; Cryptorchidism; Disease Models, Animal; Female; Fertility; Flutamide; | 2000 |
The biological effect of phthalate esters on transabdominal migration of the testis in fetal rats in comparison with the antiandrogen flutamide.
Topics: Animals; Cryptorchidism; Female; Flutamide; Gestational Age; Humans; Infant, Newborn; Male; Phthalic | 2001 |
Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens.
Topics: Androgens; Animals; Atrophy; Cryptorchidism; Drug Combinations; Female; Flutamide; Gestational Age; | 1992 |
Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide.
Topics: Androgen-Insensitivity Syndrome; Animals; Body Weight; Chi-Square Distribution; Cryptorchidism; Epid | 1992 |
Effects of flutamide and finasteride on rat testicular descent.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgens; Androstenes; Animals; Azasteroids; Cr | 1991 |
Time-specific androgen blockade with flutamide inhibits testicular descent in the rat.
Topics: 5-alpha Reductase Inhibitors; Androstenes; Animals; Azasteroids; Cryptorchidism; Embryonic and Fetal | 1991 |