flurothyl has been researched along with Seizures in 192 studies
*Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (35.94) | 18.7374 |
| 1990's | 31 (16.15) | 18.2507 |
| 2000's | 43 (22.40) | 29.6817 |
| 2010's | 37 (19.27) | 24.3611 |
| 2020's | 12 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Binder, MS; Hodges, SL; Kim, AD; Lugo, JN; Narvaiz, DA; Prankse, ZJ; Womble, PD | 1 |
| Friedman, LK; Kahen, BA; Velíšek, L; Velíšková, J | 1 |
| Brabec, JL; Hernan, AE; Mahoney, JM; Ouardouz, M; Scott, RC | 1 |
| Gataulina, E; Gerasimova, E; Khalilov, I; Kurmashova, E; Sitdikova, GF; Yakovlev, AV | 1 |
| Feng, J; Hu, XY; Shi, XY; Tang, JH; Wan, Y; Xi, XJ; Zhang, BB; Zhou, C | 1 |
| Greenberg, DA; McCarthy, E; Miller, J; Morris Cameron, E; Pathak, S; Saint Ange, P; Shakil, F; Velíšek, L; Velíšková, J | 1 |
| Binder, MS; Kim, AD; Lugo, JN | 1 |
| Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH | 1 |
| Chavez-Valdez, R; Felling, RJ; Lechner, CR; McNally, MA; Northington, FJ; St Pierre, M; Stafstrom, CE | 1 |
| Egawa, K; Goto, T; Kimura, S; Manabe, A; Nakakubo, S; Shiraishi, H | 1 |
| Binder, MS; Condon, SM; Darner, AM; Faust, AM; Hodges, SL; Kwok, EM; Lugo, JN; Nolan, SO; Quintero, SI; Senger, SS; Womble, PD | 1 |
| Barry, JM; Holmes, GL; Kloc, ML; Niedecker, RW | 1 |
| Matthews, SA; Simeone, KA; Simeone, TA | 1 |
| Beyer, BS; Ferland, RJ; Gracias, J; Hains, L; Herron, BJ; Kadiyala, SB; Kang, EY; O'Brien, B; Papandrea, D; Smith, J | 1 |
| Borges, K; McDonald, TS | 1 |
| Jin, MF; Li, LL; Li, YC; Ni, H; Zhao, DJ | 1 |
| Costa-Ferro, ZSM; Marinowic, DR; Nunes, ML; Sebben, AD; Wearick-Silva, LE | 1 |
| Holmes, GL; Isaev, D; Isaeva, E | 1 |
| Arehart, E; Hyder, SN; Kolls, BJ; Leonard, AS; Mikati, MA; Ng, KC; Veerapandiyan, A | 1 |
| Eason, DE; Kaas, GA; King, JR; Ming, GL; Ross, DL; Song, H; Sweatt, JD; Vachhani, RV; Zhong, C | 1 |
| Alvarez, PS; Hemb, M; Nunes, ML; Simão, F; Xavier, LL | 1 |
| Bishop, HI; Campi, KL; Doisy, ET; Eum, K; Golub, MS; Hell, JW; Mandikian, D; Matt, L; Nerbonne, JM; Ogata, G; Sack, JT; Schwartzkroin, PA; Speca, DJ; Trainor, BC; Trimmer, JS; Wenzel, HJ; Wiler, SW | 1 |
| Xiong, Y; Zhang, L; Zhou, H | 1 |
| Ferland, RJ; Herron, BJ; Kadiyala, SB; Papandrea, D | 1 |
| Fink, M | 1 |
| Cooper, K; Fink, M | 1 |
| Adil, SM; Arehart, E; Fainberg, NA; Forbes, SL; Helseth, AR; Hochgeschwender, U; Hochman, DW; Hunanyan, AS; Kibbi, N; Leonard, AS; Linabarger, M; Mikati, MA; Rhodes, T; Rodriguiz, RM; Swearingen, AK; Wetsel, WC; Yao, X | 1 |
| Anderson, TM; Ferland, RJ; Herron, BJ; Jayakumar, S; Kadiyala, SB; Papandrea, D; Tuz, K | 1 |
| Jellett, AP; Jenks, K; Lucas, M; Scott, RC | 1 |
| Feng, X; Ni, H; Sun, BL; Sun, Q; Tian, T | 1 |
| Holley, AJ; Lugo, JN | 1 |
| Habekost Oliveira, V; Lahorgue Nunes, M; Simão, F | 1 |
| Li, LL; Ni, H; Tian, T; Zhang, SQ | 1 |
| Beyer, BS; Ferland, RJ; Herron, BJ; Kadiyala, SB; Nalwalk, JW; Papandrea, D; Yannix, JQ | 1 |
| Hu, Q; Li, X; Liu, L; Mao, D; Shi, J; Tan, M; Xiong, J; Yi, Z | 1 |
| Jiang, YW; Jin, MF; Ni, H; Tao, LY; Wu, XR | 1 |
| Holmes, GL; Kubie, JL; Lin, H; Muller, RU | 1 |
| Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH | 1 |
| Holmes, GL; Karnam, HB; Shatskikh, T; Zhao, Q | 1 |
| Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R | 2 |
| Jiang, YW; Jin, MF; Ni, H; Tao, LY; Wu, XR; Xiao, ZJ | 1 |
| Cammarota, M; Hemb, M; Nunes, ML | 1 |
| Florian, ML; Nunes, ML | 2 |
| Feng, X; Jin, MF; Ni, H; Tao, LY; Xiao, ZJ | 1 |
| Velíšek, L | 1 |
| Khazipov, R; Minlebaev, M | 1 |
| Holmes, GL; Lenck-Santini, PP; Lucas, MM; Scott, RC | 1 |
| Borges, K; Catterall, WA; Dutton, SB; Escayg, A; Jumbo-Lucioni, P; Kalume, F; Sawyer, NT | 1 |
| Hernan, AE; Holmes, GL; Kleen, JK; Miller, FA; Scott, RC; Sesqué, A; Wu, EX | 1 |
| Deykun, K; Krýsl, D; Mareš, J; Pometlová, M; Rokyta, R | 1 |
| Fox, SE; Hangya, B; Lin, H; Muller, RU | 1 |
| Nunes, ML; Porto, JA; Simão, F | 1 |
| Balakrishnan, B; Dutton, SB; Escayg, A; Makinson, CD; Nakazawa, K; Papale, LA; Shankar, A | 1 |
| Applegate, CD; Kriscenski-Perry, E; Leonardo, CC; Mhyre, TR; Pearce, DA; Serour, A | 1 |
| Araki, H; Futagami, K; Gomita, Y; Hashimoto, Y; Kawasaki, H; Kobayashi, Y | 1 |
| Applegate, CD; Ferland, RJ; Gross, RA | 1 |
| Eger, EI; Flood, P; Gong, D; Raines, DE; Xing, Y | 1 |
| Rho, JM; Sankar, R; Storey, TW; Szot, P; White, SS | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y | 1 |
| Araki, H; Futagami, K; Gomita, Y; Hashimoto, Y; Kawasaki, H | 1 |
| ESQUIBEL, A; KRANTZ, JC; KURLAND, AA; TRUITT, EB | 1 |
| KRANTZ, JC; KURLAND, AA; LING, AS; TRUITT, EB | 2 |
| CHATRIAN, GE; PETERSEN, MC | 1 |
| MACKEY, JP; ORTH, OS | 1 |
| ADLER, MW | 1 |
| BUTLER, HR; MANAX, SJ; STAVRAKY, GW | 1 |
| KURLAND, AA; NUSSBAUM, K | 1 |
| Emmi, A; Patel, LS; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ; Yeung, RS | 1 |
| Bo, T; Cao, H; Jiang, Y; Wang, J; Wu, X | 1 |
| Hoffmann, AF; Holmes, GL; Zhao, Q | 1 |
| Anderson, GD; Shen, DD; Szot, P; White, SS | 1 |
| Holmes, GL; Hu, Y; Zhao, Q | 1 |
| Slamberová, R | 1 |
| Liles, LC; Schank, JR; Weinshenker, D | 1 |
| Ahern, TH; Eagles, DA; Javors, MA; Liles, LC; Martillotti, J; Mitchell, HA; Weinshenker, D | 1 |
| Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K | 1 |
| Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J | 1 |
| Bo, T; Liu, LQ; Mao, DA | 1 |
| Bo, T; Chen, Y; Li, YF; Mao, DA; Zhu, XH | 2 |
| Holmes, GL; Lenck-Santini, PP; Zhao, Q; Zhou, JL | 1 |
| Fisher, RS; Kraus, AC; Oommen, J | 1 |
| Boss-Williams, KA; Tabb, K; Weinshenker, D; Weiss, JM | 1 |
| Holmes, GL; Liu, X; Shatskikh, TN; Zhou, JL | 1 |
| Bernásková, K; Matejovská, I; Schutová, B; Slamberová, R | 1 |
| Adler, MW; Cowan, A; Tortella, FC | 3 |
| Bhanot, R; Wilkinson, M | 2 |
| Crabbe, JC; McSwigan, JD; Young, ER | 1 |
| Albala, BJ; Moshé, SL | 1 |
| Carl, GF; Smith, DB | 1 |
| Bhanot, R; Donald, L; Pincock, JA; Wilkinson, M | 1 |
| Collins, P; Eger, EI; Johnson, BH; Koblin, DD; Speers, L; Terrell, RC | 1 |
| Browning, RA; Simonton, RL; Turner, FJ | 1 |
| Garant, DS; Moshé, SL; Sperber, EF; Xu, SG | 4 |
| Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J | 1 |
| Moshé, SL; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J | 1 |
| Ahdab-Barmada, M; Clyde, C; Kofke, WA; Nemoto, E; Rose, M | 1 |
| Garant, DS; Moshé, SL; Velísková, J; Xu, SG | 1 |
| Gatt, A; Holmes, GL; Liu, Z; Mikati, MA; Stafstrom, CE; Thurber, SJ | 1 |
| Holmes, GL; Stafstrom, CE; Thompson, JL | 2 |
| Cammer, W; Moshé, SL; Velísek, L; Xu, SG | 1 |
| Cammer, W; Moshé, SL; Velíŝek, L | 1 |
| Firkusny, IR; Jensen, FE; Mower, GD | 1 |
| Chronopoulos, A; Holmes, GL; Hyde, PA; Mikati, MA; Stafstrom, CE; Thompson, JL; Thurber, SJ | 1 |
| Baraban, SC; Schwartzkroin, PA | 1 |
| Holmes, GL; Liu, Z | 1 |
| Lánský, P; Velísek, L; Velísková, J | 1 |
| Applegate, CD; Ferland, RJ | 1 |
| Applegate, CD; Piekut, DT; Samoriski, GM | 1 |
| Löscher, W; Moshé, SL; Velísková, J | 1 |
| Moshé, SL; Vathy, I; Velísek, L; Velísková, J | 1 |
| Anderson, ME; Fitzpatrick, JH; Gilboe, DD; Kintner, DB | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Gairsa, JL; Holmes, GL | 1 |
| Etgen, AM; Moshé, SL; Stanton, PK; Velísek, L; Velísková, J | 1 |
| Holmes, GL; Schmid, R; Stafstrom, CE; Tandon, P | 1 |
| Anderson, GD; Kim, DW; Rho, JM; Robbins, CA; Schwartzkroin, PA | 1 |
| Palmiter, RD; Robbins, CA; Rust, NC; Schwartzkroin, PA; Szot, P; Weinshenker, D; White, SS | 1 |
| Cilio, MR; Holmes, GL; Huang, L; McCabe, BK; Silveira, DC; Sogawa, Y; Stafstrom, CE | 1 |
| Holmes, GL; Schachter, SC; Schomer, DL; Silveira, DC | 1 |
| Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Woolley, CS | 1 |
| Ben-Ari, Y; Gaiarsa, JL; Holmes, GL; Villeneuve, N | 1 |
| Liptáková, S; Moshé, SL; Velísek, L; Velísková, J | 1 |
| Bolanos, AR; Cilio, MR; Holmes, GL; Liu, Z; Mikati, MA; Schmid, R; Stafstrom, CE; Yang, Y | 1 |
| Cha, BH; Cilio, MR; Holmes, GL; Liu, X; McCabe, BK; Silveira, DC; Sogawa, Y | 1 |
| Hohmann, JG; Miller, NS; Palmiter, RD; Pyati, U; Rust, NC; Szot, P; Weinshenker, D; White, SS | 1 |
| Gernert, M; Löscher, W | 1 |
| Hussain, S; Liptáková, S; Velísková, J | 1 |
| Moshé, SL; Velísek, L; Velísková, J | 1 |
| Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, CL; Wang, TJ; Yang, SN | 1 |
| Adler, MW; Cowan, A; Geller, EB | 2 |
| Duffy, TE; Howse, DC; Plum, F | 2 |
| Conn, M; Fando, JL; Wasterlain, CG | 1 |
| Cherkin, A; Davis, JL; Eckardt, MJ; Gerbrandt, LK | 1 |
| Bierkamper, GG; Cenedella, RJ | 1 |
| Browning, RA; Maynert, EW | 1 |
| Sanders, B; Sharpless, SK | 1 |
| Wasterlain, CG | 3 |
| Alpern, HP; Greer, CA | 1 |
| Adler, MW; Kramer, MS | 2 |
| Alpern, HP; Collins, AC; Greer, CA | 1 |
| Bierkamper, GG; Cenedella, RJ; Crouthamel, WG; Westfall, DP | 1 |
| Ioannou, P; Mathias, AP; Wynter, CV | 1 |
| Golub, M; Kornetsky, C | 2 |
| Alpern, HP; Collins, AC; Greer, CA; Olson, RK; Stripling, JS | 1 |
| Cherkin, A; Riege, WH | 2 |
| Brown, LL; Moshé, SL; Sperber, EF; Tempel, A | 1 |
| Brown, EE; Damsma, G; Fibiger, HC; Nomikos, GG; Zis, AP | 1 |
| Moshé, SL; Sperber, EF; Wurpel, JN | 1 |
| Ingvar, M | 1 |
| Holaday, JW; Tortella, FC | 1 |
| Albala, BJ; Moshé, SL; Okada, R | 1 |
| Holaday, JW; Robles, L; Tortella, FC | 1 |
| Gaffney, D; Marley, RJ; Wehner, JM | 1 |
| Holaday, JW; Long, JB; Maneckjee, R; Tortella, FC | 1 |
| Boisse, N; Guarino, J; Samoriski, G | 1 |
| Maher, TJ; Pinto, JM | 1 |
| Moshé, SL; Sperber, EF | 1 |
| Moshé, SL; Wong, BY | 1 |
| Alpern, HP; McIntyre, TD | 1 |
| Green, AR; Minchin, MC; Vincent, ND | 1 |
| Green, AR; Metz, A; Minchin, MC; Vincent, ND | 1 |
| Bierkamper, G; Dawson, R | 1 |
| Appleyard, ME; Green, AR; Smith, AD | 1 |
| Smolen, A; Smolen, TN; van de Kamp, JL | 1 |
| Smolen, A; Smolen, TN | 1 |
| Ingvar, M; Nergelius, G; Nevander, G; Siesjö, BK; von Hanwehr, R | 1 |
| Folbergrová, J; Ingvar, M; Nevander, G; Siesjö, BK | 1 |
| Albala, BJ; Moshé, SL; Okada, R; Ono, K | 1 |
| Glaser, GH | 1 |
| Mettler, FA; Sax, DS | 1 |
| Herberg, LJ; Tress, KH | 1 |
| Cooper, RG; Webb, OL | 1 |
| Racusen, LC; Smith, DB | 1 |
| Adler, MW; Gildenberg, PL; Lin, C; Smith, KP; Tresky, R | 1 |
3 review(s) available for flurothyl and Seizures
| Article | Year |
|---|---|
The seizure, not electricity, is essential in convulsive therapy: the flurothyl experience.
Topics: Convulsants; Convulsive Therapy; Electroconvulsive Therapy; Flurothyl; Humans; Mental Disorders; Seizures | 2014 |
The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely?
Topics: Animals; Electroconvulsive Therapy; Flurothyl; Humans; Memory Disorders; Mental Disorders; Pentylenetetrazole; Seizures | 2014 |
Brain dysfunction in uremia.
Topics: Acute Kidney Injury; Animals; Benzoates; Blood; Blood Urea Nitrogen; Brain; Cats; Electroencephalography; Flurothyl; Humans; Ligation; Myoclonus; Neurologic Manifestations; Osmolar Concentration; Rats; Renal Dialysis; Seizures; Sodium Chloride; Sucrose; Urea; Uremia | 1974 |
1 trial(s) available for flurothyl and Seizures
| Article | Year |
|---|---|
Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures.
Topics: Adrenocorticotropic Hormone; Animals; Dexamethasone; Flurothyl; Gene Expression Regulation; Hippocampus; Quality of Life; Rats; Rats, Sprague-Dawley; Seizures | 2022 |
188 other study(ies) available for flurothyl and Seizures
| Article | Year |
|---|---|
A flurothyl-induced seizure does not disrupt hippocampal memory reconsolidation in C57BL/6 J mice.
Topics: Animals; Fear; Flurothyl; Hippocampus; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Quality of Life; Seizures | 2022 |
Sex differences in behavioral pathology induced by subconvulsive stimulation during early postnatal life are overcome by epileptic activity in the pre-juvenile weanling period.
Topics: Animals; Epilepsy; Female; Flurothyl; Hippocampus; Humans; Kainic Acid; Male; Rats; Seizures; Sex Characteristics; Status Epilepticus | 2022 |
Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats.
Topics: Animals; Animals, Newborn; Epilepsy; Female; Flurothyl; gamma-Aminobutyric Acid; Hippocampus; Hyperhomocysteinemia; Pregnancy; Rats; Seizures | 2023 |
Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits.
Topics: Animals; Brain; Brain Injuries; Epilepsy, Generalized; Female; Flurothyl; gamma-Aminobutyric Acid; Hippocampus; Male; Rats, Wistar; Receptors, GABA-A; Seizures | 2020 |
Developmental decrease in parvalbumin-positive neurons precedes increase in flurothyl-induced seizure susceptibility in the Brd2
Topics: Androstenedione; Animals; Disease Models, Animal; Female; Flurothyl; GABAergic Neurons; Male; Mice; Mice, Inbred C57BL; Myoclonic Epilepsy, Juvenile; Neurons; Parvalbumins; Seizures; Testosterone Propionate; Transcription Factors | 2020 |
An acute seizure prior to memory reactivation transiently impairs associative memory performance in C57BL/6J mice.
Topics: Animals; Association Learning; Behavior, Animal; Conditioning, Classical; Convulsants; Disease Models, Animal; Fear; Female; Flurothyl; Male; Memory Disorders; Mice, Inbred C57BL; Seizures; Time Factors | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flurothyl; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenotype; Quantitative Trait Loci; Seizures; Sudden Unexpected Death in Epilepsy; Whole Genome Sequencing | 2020 |
Sex specific correlation between GABAergic disruption in the dorsal hippocampus and flurothyl seizure susceptibility after neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Convulsants; Disease Susceptibility; Flurothyl; GABAergic Neurons; Hippocampus; Hypoxia-Ischemia, Brain; Interneurons; Mice; Parvalbumins; Seizures; Sex Factors | 2021 |
Flurothyl-induced seizure paradigm revealed higher seizure susceptibility in middle-aged Angelman syndrome mouse model.
Topics: Angelman Syndrome; Animals; Disease Models, Animal; Disease Susceptibility; Flurothyl; Male; Mice; Seizures; Tetrazoles; Ubiquitin-Protein Ligases | 2021 |
Rapamycin, but not minocycline, significantly alters ultrasonic vocalization behavior in C57BL/6J pups in a flurothyl seizure model.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy; Female; Flurothyl; Immunologic Factors; Male; Mice; Mice, Inbred C57BL; Minocycline; MTOR Inhibitors; Seizures; Sex Factors; Sirolimus; Vocalization, Animal | 2021 |
Effects of early life seizures on coordination of hippocampal-prefrontal networks: Influence of sex and dynamic brain states.
Topics: Animals; Avoidance Learning; Brain; CA1 Region, Hippocampal; Cognition; Convulsants; Electrodes, Implanted; Electroencephalography; Female; Flurothyl; Hippocampus; Male; Maze Learning; Nerve Net; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Seizures; Sex Characteristics; Sleep; Space Perception; Theta Rhythm | 2021 |
Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Convulsants; Diet, Ketogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Flurothyl; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Pioglitazone; Reaction Time; Seizures; Thiazolidinediones | 2017 |
Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus.
Topics: Alleles; Animals; Brain; Chromosomes, Mammalian; Crosses, Genetic; Disease Models, Animal; Epilepsy; Epistasis, Genetic; Female; Flurothyl; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Kindling, Neurologic; Male; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Regression Analysis; Seizures | 2017 |
Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase.
Topics: Alanine; Amino Acids; Animals; Antioxidants; Blood Glucose; Citric Acid Cycle; Flurothyl; Gas Chromatography-Mass Spectrometry; Glycogen; Hippocampus; Lactic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Phosphofructokinases; Phosphorylation; Pyruvate Dehydrogenase Complex; Seizures; Superoxide Dismutase | 2017 |
Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex.
Topics: Animals; Animals, Newborn; Autophagy; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Flurothyl; Group IV Phospholipases A2; Leptin; Male; Motor Activity; Neuroprotection; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2018 |
Undernourishment and recurrent seizures early in life impair Long-Term Potentiation and alter NMDAR and AMPAR expression in rat hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Flurothyl; Gene Expression; Hippocampus; Long-Term Potentiation; Malnutrition; Maternal Deprivation; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 2019 |
Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex.
Topics: Animals; Animals, Newborn; Convulsants; Electroencephalography; Flurothyl; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Seizures; Somatosensory Cortex; Synapses | 2013 |
Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Electroencephalography; Flurothyl; Genetic Predisposition to Disease; Heterozygote; Hippocampus; Humans; Hypoxia; Kindling, Neurologic; Kv1.1 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Seizures | 2013 |
TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.
Topics: Adenoviridae; Analysis of Variance; Animals; Animals, Newborn; Cells, Cultured; Central Nervous System; Chrysenes; Conditioning, Classical; Convulsants; Cytosine; DNA Methylation; DNA-Binding Proteins; Flurothyl; Gene Expression Regulation; Hippocampus; Hydroxylation; Luminescent Proteins; Male; Memory; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Motor Activity; Mutation; Nerve Tissue Proteins; Neurons; Potassium Chloride; Proto-Oncogene Proteins; Seizures; Time Factors; Transcription, Genetic; Transduction, Genetic | 2013 |
Effects of undernourishment, recurrent seizures and enriched environment during early life in hippocampal morphology.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Cell Count; Convulsants; Disease Models, Animal; Environment; Female; Flurothyl; Hippocampus; Male; Malnutrition; Neuroglia; Neurons; Pregnancy; Rats; Rats, Wistar; Seizures | 2014 |
Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.
Topics: Action Potentials; Animals; Convulsants; Flurothyl; Gene Deletion; Hippocampus; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Phenotype; Pilocarpine; Seizures; Shab Potassium Channels | 2014 |
Influences of hyperthermia-induced seizures on learning, memory and phosphorylative state of CaMKIIα in rat hippocampus.
Topics: Animals; Blotting, Western; Calcium-Binding Proteins; Carrier Proteins; Convulsants; Disease Models, Animal; Flurothyl; Hippocampus; Hot Temperature; Male; Maze Learning; Memory; Neurons; Neuropsychological Tests; Phosphorylation; Physical Stimulation; Post-Synaptic Density; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Space Perception | 2014 |
Segregation of seizure traits in C57 black mouse substrains using the repeated-flurothyl model.
Topics: Analysis of Variance; Animals; Crosses, Genetic; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Flurothyl; Male; Mice; Mice, Inbred C57BL; Seizures; Species Specificity | 2014 |
Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Electrophysiological Phenomena; Flurothyl; Gene Knock-In Techniques; Hemiplegia; Kindling, Neurologic; Learning; Locomotion; Memory; Mice; Mice, Transgenic; Seizures; Sodium-Potassium-Exchanging ATPase | 2015 |
Spatiotemporal differences in the c-fos pathway between C57BL/6J and DBA/2J mice following flurothyl-induced seizures: A dissociation of hippocampal Fos from seizure activity.
Topics: Animals; Blotting, Western; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Extracellular Signal-Regulated MAP Kinases; Flurothyl; Gene Expression; Genetic Predisposition to Disease; Hippocampus; Immunohistochemistry; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Proto-Oncogene Proteins c-fos; Seizures; Species Specificity | 2015 |
Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cognition; Cognition Disorders; Disease Models, Animal; Epilepsy; Female; Flurothyl; Hippocampus; Malformations of Cortical Development; Maze Learning; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Sprague-Dawley; Seizures; Survival Analysis; Valproic Acid | 2015 |
Prophylactic treatment with melatonin before recurrent neonatal seizures: Effects on long-term neurobehavioral changes and the underlying expression of metabolism-related genes in rat hippocampus and cerebral cortex.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Animals, Newborn; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cathepsin E; Cerebral Cortex; Female; Flurothyl; Gene Expression Regulation; Hippocampus; Male; Maze Learning; Melatonin; Metabolism; Rats; Reflex; Seizures | 2015 |
Effects of an acute seizure on associative learning and memory.
Topics: Animals; Association Learning; Fear; Flurothyl; Memory; Mental Recall; Mice; Seizures | 2016 |
Enhanced susceptibility to seizures modulated by high interleukin-1β levels during early life malnutrition.
Topics: Animals; Animals, Newborn; Blotting, Western; Corticosterone; Disks Large Homolog 4 Protein; Enzyme-Linked Immunosorbent Assay; Flurothyl; Hippocampus; Immunologic Factors; Interleukin-1beta; Intracellular Signaling Peptides and Proteins; Malnutrition; Maternal Deprivation; Membrane Proteins; Models, Animal; Receptors, Interleukin-1 Type I; Seizures; Synapsins | 2016 |
Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.
Topics: Animals; Brain Injuries; Cation Transport Proteins; Cerebral Cortex; Diet, Ketogenic; Female; Flurothyl; Gene Expression Regulation; Hippocampus; Male; Metallothionein; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Seizures | 2016 |
Eight Flurothyl-Induced Generalized Seizures Lead to the Rapid Evolution of Spontaneous Seizures in Mice: A Model of Epileptogenesis with Seizure Remission.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Fluoresceins; Flurothyl; Hippocampus; Male; Mice; Mice, Inbred C57BL; Seizures; Time Factors; Video Recording | 2016 |
MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures.
Topics: Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cells, Cultured; Disease Models, Animal; Flurothyl; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Microarray Analysis; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Transcriptome | 2016 |
ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats.
Topics: Age Factors; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin-Binding Proteins; Cation Transport Proteins; Cognition; Cognition Disorders; Disease Models, Animal; Flurothyl; Hippocampus; Male; Maze Learning; Membrane Proteins; Memory; Mossy Fibers, Hippocampal; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Reaction Time; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Spatial Behavior; Staining and Labeling | 2009 |
Recurrent seizures induce a reversible impairment in a spatial hidden goal task.
Topics: Analysis of Variance; Animals; Cognition Disorders; Flurothyl; Goals; Locomotion; Male; Maze Learning; Random Allocation; Rats; Rats, Long-Evans; Seizures; Space Perception; Time Factors | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors | 2009 |
Effect of age on cognitive sequelae following early life seizures in rats.
Topics: Age of Onset; Aging; Animals; Avoidance Learning; Behavior, Animal; Cognition; Convulsants; Flurothyl; Hippocampus; Learning; Long-Term Potentiation; Male; Maze Learning; Memory; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2009 |
Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex.
Topics: Animals; Animals, Newborn; Flurothyl; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Miniature Postsynaptic Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Seizures; Somatosensory Cortex; Synaptic Transmission; Time | 2009 |
Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Calmodulin-Binding Proteins; Cation Transport Proteins; Convulsants; Flurothyl; Gene Expression Regulation; Male; Membrane Proteins; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2010 |
Effects of early malnutrition, isolation and seizures on memory and spatial learning in the developing rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Brain; Exploratory Behavior; Flurothyl; Male; Malnutrition; Maternal Deprivation; Maze Learning; Memory; Motor Activity; Rats; Rats, Wistar; Seizures; Spatial Behavior; Status Epilepticus | 2010 |
Effects of intra-uterine and early extra-uterine malnutrition on seizure threshold and hippocampal morphometry of pup rats.
Topics: Animals; Brain; Cell Count; Convulsants; Female; Flurothyl; Hippocampus; Lactation; Male; Malnutrition; Maternal-Fetal Exchange; Neurons; Organ Size; Pregnancy; Pregnancy Complications; Random Allocation; Rats; Rats, Wistar; Seizures | 2010 |
Dynamic pattern of gene expression of ZnT-4, caspase-3, LC3, and PRG-3 in rat cerebral cortex following flurothyl-induced recurrent neonatal seizures.
Topics: Animals; Animals, Newborn; Base Sequence; Carrier Proteins; Caspase 3; Cerebral Cortex; DNA Primers; Flurothyl; Gene Expression; Male; Membrane Transport Proteins; Microtubule-Associated Proteins; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2011 |
Prenatal corticosteroid exposure alters early developmental seizures and behavior.
Topics: Animals; Anxiety; Betamethasone; Canrenoic Acid; Convulsants; Disease Susceptibility; Exploratory Behavior; Female; Flurothyl; Hydrocortisone; Kainic Acid; Male; Maze Learning; Mineralocorticoid Receptor Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Seizures; Status Epilepticus; Weight Gain | 2011 |
Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Suckling; Anticonvulsants; Brain; Bumetanide; Convulsants; Diazepam; Diet, Ketogenic; Dietary Fats; Disease Susceptibility; Electroencephalography; Flurothyl; Glucose; Hypoglycemia; Insulin; Ketone Bodies; Ketosis; Milk; Rats; Seizures; Somatosensory Cortex; Thioglycolates | 2011 |
Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures.
Topics: Age Factors; Animals; Animals, Newborn; Cognition Disorders; Disease Models, Animal; Embryo, Mammalian; Female; Flurothyl; Hippocampus; Malformations of Cortical Development; Maze Learning; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures | 2011 |
Protective effect of the ketogenic diet in Scn1a mutant mice.
Topics: 3-Hydroxybutyric Acid; Animals; Convulsants; Diet, Ketogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Generalized; Epithelial Sodium Channels; Flurothyl; Mice; Mice, Knockout; Seizures; Weight Gain | 2011 |
Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex.
Topics: Animals; Animals, Newborn; Conditioning, Operant; Disease Models, Animal; Electroencephalography; Flurothyl; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Seizures | 2011 |
Effects of intra-uterine and early extra-uterine malnutrition on seizure threshold and hippocampal morphometry of pup rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Cell Count; Dentate Gyrus; Female; Flurothyl; Malnutrition; Maternal Nutritional Physiological Phenomena; Models, Animal; Neurons; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures; Uterus | 2011 |
An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin.
Topics: Analysis of Variance; Animals; Antioxidants; Automatism; Blood-Brain Barrier; Convulsants; Disease Models, Animal; Flurothyl; Hypoxia; Learning Disabilities; Male; Maze Learning; Melatonin; Rats; Reaction Time; Seizures; Time Factors | 2012 |
Repetitive convulsant-induced seizures reduce the number but not precision of hippocampal place cells.
Topics: Action Potentials; Animals; Brain Mapping; Brain Waves; Convulsants; Disease Models, Animal; Drug Administration Schedule; Electrodes, Implanted; Electroencephalography; Fasting; Flurothyl; Hippocampus; Male; Models, Neurological; Neurons; Rats; Rats, Long-Evans; Seizures; Statistics, Nonparametric; Time Factors | 2012 |
Effects of enriched environment in spatial learning and memory of immature rats submitted to early undernourish and seizures.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Environment; Female; Flurothyl; Male; Malnutrition; Maze Learning; Pregnancy; Rats; Reaction Time; Retention, Psychology; Seizures; Spatial Behavior; Time Factors | 2012 |
Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Susceptibility; Fever; Flurothyl; Hippocampus; Interneurons; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; NAV1.1 Voltage-Gated Sodium Channel; Neocortex; Neural Inhibition; Parvalbumins; Pyramidal Cells; Seizures; Seizures, Febrile | 2013 |
Altered flurothyl seizure induction latency, phenotype, and subsequent mortality in a mouse model of juvenile neuronal ceroid lipofuscinosis/batten disease.
Topics: Administration, Inhalation; Age Factors; Animals; Disease Models, Animal; Flurothyl; Humans; Membrane Glycoproteins; Mice; Mice, Neurologic Mutants; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Phenotype; Proteins; Seizures | 2002 |
Characteristics of flurothyl-induced seizures and the effect of antiepileptic drugs on flurothyl-induced seizures in Mongolian gerbils.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electrodes, Implanted; Electroencephalography; Epilepsy, Tonic-Clonic; Flurothyl; Gerbillinae; Male; Seizures | 2002 |
Differences in hippocampal mitotic activity within the dorsal and ventral hippocampus following flurothyl seizures in mice.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Convulsants; Flurothyl; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mitosis; Phenotype; Seizures; Stem Cells | 2002 |
Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.
Topics: Animals; Chlorofluorocarbons; Cyclobutanes; Flurothyl; GABA-A Receptor Antagonists; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Nicotinic; Seizures | 2002 |
Age-dependent differences in flurothyl-induced c-fos and c-jun mRNA expression in the mouse brain.
Topics: Age Factors; Animals; Brain; Convulsants; Flurothyl; Genes, fos; Male; Mice; Proto-Oncogene Proteins c-jun; RNA, Messenger; Seizures | 2002 |
Cessation of repeated administration of MK-801 changes the anticonvulsant effect against flurothyl-induced seizure in mice.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flurothyl; Male; Mice; Mice, Inbred C57BL; Seizures | 2003 |
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Phenytoin; Prosencephalon; Seizures; Time Factors; Valproic Acid; Zonisamide | 2003 |
The use of hexafluorodiethyl ether (indoklon) as an inhalant convulsant.
Topics: Convulsants; Ether; Ethers; Fluorides; Flurothyl; Seizures | 1957 |
Some pharmacologic aspects of indoklon, a new pharmacoconvulsive agent.
Topics: Ether; Ethers; Fluorides; Flurothyl; Seizures | 1958 |
Sustained exposure to hexafluorodiethyl ether (indoklon) in mental illness.
Topics: Ether; Ethers; Fluorides; Flurothyl; Seizures | 1959 |
The convulsive patterns provoked by indoklon, metrazol and electroshock: some depth electrographic observations in human patients.
Topics: Electroencephalography; Electroshock; Flurothyl; Humans; Pentylenetetrazole; Seizures | 1960 |
Laboratory evaluation of Indoklon.
Topics: Ether; Ethers; Flurothyl; Laboratories; Seizures | 1963 |
INCREASED SENSITIVITY TO PENTYLENETETRAZOL AND FLUROTHYL FOLLOWING CORTICAL ABLATIONS IN RATS.
Topics: Central Nervous System Stimulants; Cerebral Cortex; Cerebral Decortication; Flurothyl; Pentylenetetrazole; Pharmacology; Research; Seizures; Toxicology | 1965 |
HEXAFLUORODIETHYL ETHER (INDOKLON) CONVULSIONS IN CORPUS-CALLOTOMIZED WHITE RATS.
Topics: Brain; Corpus Callosum; Drug Tolerance; Ether; Ethers; Flurothyl; Hypoxia, Brain; Pentylenetetrazole; Rats; Research; Seizures; Toxicology | 1964 |
Intravenous hexafluorodiethyl ether (indoklon) modified by succinylcholine chloride. Clinical studies in convulsive psychiatric treatment.
Topics: Biomedical Research; Ether; Ethers; Flurothyl; Psychosurgery; Psychotherapy; Seizures; Succinylcholine | 1962 |
Morphology of cerebral lesions in the Eker rat model of tuberous sclerosis.
Topics: Animals; Astrocytes; Cerebral Cortex; Disease Models, Animal; Flurothyl; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Immunohistochemistry; Intermediate Filament Proteins; Isoenzymes; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344; Rats, Mutant Strains; Reaction Time; Repressor Proteins; Seizures; Staining and Labeling; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Whole-Body Irradiation | 2004 |
Long-term effects of seizures in neonatal rats on spatial learning ability and N-methyl-D-aspartate receptor expression in the brain.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Female; Flurothyl; Glutamic Acid; Hippocampus; Learning Disabilities; Male; Maze Learning; Memory Disorders; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Space Perception; Synaptic Transmission; Telencephalon; Time Factors | 2004 |
Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis".
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cell Death; Cognition Disorders; Drug Interactions; Flurothyl; Hippocampus; Maze Learning; Pilocarpine; Rats; Rats, Long-Evans; Reaction Time; Recurrence; Seizures; Status Epilepticus; Time Factors | 2004 |
Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Flurothyl; Gene Expression Regulation; In Situ Hybridization; Lamotrigine; Male; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Reaction Time; RNA, Messenger; Seizures; Triazines; Valproic Acid | 2005 |
Effect of topiramate on cognitive function and activity level following neonatal seizures.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Body Weight; Cognition; Drug Interactions; Exploratory Behavior; Flurothyl; Fructose; Hippocampus; Maze Learning; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Topiramate | 2005 |
Flurothyl seizures susceptibility is increased in prenatally methamphetamine-exposed adult male and female rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Estrous Cycle; Female; Flurothyl; Male; Methamphetamine; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Wistar; Seizures; Sex Factors | 2005 |
Reduced anticonvulsant efficacy of valproic acid in dopamine beta-hydroxylase knockout mice.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Combinations; Flurothyl; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Norepinephrine; Reaction Time; Reboxetine; Seizures; Valproic Acid | 2005 |
The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Disease Models, Animal; Dopamine beta-Hydroxylase; Drug Administration Schedule; Electroshock; Flurothyl; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Norepinephrine Plasma Membrane Transport Proteins; Pentylenetetrazole; Reaction Time; Reboxetine; Seizures | 2006 |
Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures.
Topics: Animals; Animals, Newborn; Convulsants; Data Interpretation, Statistical; Excitatory Postsynaptic Potentials; Extracellular Space; Flurothyl; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kinetics; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission | 2006 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; GABA Antagonists; GABA-A Receptor Antagonists; Gerbillinae; Male; Picrotoxin; Receptors, GABA-A; Seizures; Valproic Acid | 2006 |
Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development.
Topics: 2-Amino-5-phosphonovalerate; Acrylates; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Castration; Convulsants; Female; Flurothyl; GABA Agonists; GABA-A Receptor Agonists; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Sex Factors; Substantia Nigra; Testosterone Propionate | 2006 |
[Expression and significance of caspase-1, IL-18 and IL-1beta in the hippocampus of the developing recurrent seizures rats].
Topics: Animals; Caspase 1; Disease Models, Animal; Female; Flurothyl; Gene Expression Regulation; Hippocampus; Interleukin-18; Interleukin-1beta; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Time Factors; Up-Regulation | 2006 |
[Long-term effects of neonatal recurrent seizures on gamma-aminobutyric acid A receptor alpha1 and gamma2 subunit expressions in the rat brain].
Topics: Animals; Animals, Newborn; Brain; Flurothyl; Immunohistochemistry; Maze Learning; Protein Subunits; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Time Factors | 2006 |
Effect of interictal spikes on single-cell firing patterns in the hippocampus.
Topics: Action Potentials; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Flurothyl; Hippocampus; Interneurons; Lithium Compounds; Male; Microelectrodes; Neurons; Patch-Clamp Techniques; Pilocarpine; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Spatial Behavior; Walking | 2007 |
Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold.
Topics: Amines; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Flurothyl; Gabapentin; gamma-Aminobutyric Acid; Injections, Intraventricular; Methylene Blue; Nerve Fibers, Myelinated; Rats; Rats, Sprague-Dawley; Seizures; Staining and Labeling; Time Factors; Treatment Outcome | 2007 |
Rats bred for susceptibility to depression-like phenotypes have higher kainic acid-induced seizure mortality than their depression-resistant counterparts.
Topics: Animals; Convulsants; Depression; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Flurothyl; Kainic Acid; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures; Stress, Psychological | 2007 |
[Long-term effects of recurrent seizures in neonate period on gamma-aminobutyric acid A receptor alpha1 and beta2 subunits expression in adult brain: experiment with rats].
Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Disease Models, Animal; Flurothyl; Hippocampus; Immunohistochemistry; Maze Learning; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Time Factors | 2007 |
Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures.
Topics: Action Potentials; Animals; Brain Mapping; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Flurothyl; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Spatial Behavior; Spectrum Analysis; Swimming; Time Factors | 2007 |
Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?
Topics: Animals; Body Weight; Disease Susceptibility; Dopamine Agents; Drug Administration Schedule; Estrous Cycle; Female; Flurothyl; Male; Methamphetamine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures; Sex Factors | 2008 |
Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.
Topics: Animals; Anticonvulsants; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Flurothyl; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1981 |
Differential effects of flurothyl- and electro-convulsive shock on sexual maturation and prolactin release in the rat.
Topics: Animals; Bromocriptine; Electroshock; Endorphins; Female; Flurothyl; Follicle Stimulating Hormone; Haloperidol; Luteinizing Hormone; Prolactin; Rats; Rats, Inbred Strains; Seizures; Sexual Maturation | 1984 |
Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Flurothyl; Injections, Intraventricular; Male; Meperidine; Naloxone; Narcotics; Pentazocine; Rats; Rats, Inbred Strains; Seizures; Thebaine | 1984 |
Specific ethanol withdrawal seizures in genetically selected mice.
Topics: Animals; Anticonvulsants; Electroshock; Ethanol; Flurothyl; GABA Antagonists; Humans; Male; Mice; Seizures; Strychnine; Substance Withdrawal Syndrome | 1984 |
Nigral muscimol infusions facilitate the development of seizures in immature rats.
Topics: Age Factors; Animals; Flurothyl; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Rats; Seizures; Substantia Nigra | 1984 |
Interactions between folates and carbamazepine or valproate in the rat.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Flurothyl; Folic Acid; Leucovorin; Male; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1982 |
Flurothyl-induced convulsions delay the onset of sexual maturation in the female rat.
Topics: Animals; Castration; Female; Flurothyl; Follicle Stimulating Hormone; In Vitro Techniques; Luteinizing Hormone; Ovulation; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Seizures; Sexual Maturation | 1982 |
Repeated convulsions induce pseudopregnancy in the intact rat and inhibit steroid-mediated gonadotrophin secretion in the ovariectomized rat.
Topics: Animals; Bromocriptine; Castration; Estrus; Female; Flurothyl; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Luteinizing Hormone; Pituitary Gland, Anterior; Pregnancy; Progesterone; Pseudopregnancy; Rats; Seizures | 1982 |
Are convulsant gases also anesthetics?
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Convulsants; Dogs; Female; Flurothyl; Isoflurane; Male; Mice; Mice, Inbred ICR; Seizures | 1981 |
A comparison of the anticonvulsant effects of two systemically active enkephalin analogues in rats.
Topics: Animals; Anticonvulsants; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Flurothyl; Male; Naloxone; Rats; Seizures | 1981 |
Antagonism of experimentally induced tonic seizures following a lesion in the midbrain tegmentum.
Topics: Animals; Disease Models, Animal; Electroshock; Flurothyl; Hindlimb; Male; Muscles; Pentylenetetrazole; Rats; Seizures; Tegmentum Mesencephali | 1981 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1995 |
Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Convulsants; Flurothyl; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Organophosphorus Compounds; Phenobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Seizures; Vigabatrin | 1995 |
Effects of MK-801 and phenytoin on flurothyl-induced seizures during development.
Topics: Age Factors; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Flurothyl; Male; Phenytoin; Rats; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Substantia nigra damage after fluorothyl-induced seizures in rats worsens after post-seizure recovery: no exacerbation with hyperglycaemia.
Topics: Acidosis, Lactic; Animals; Electroencephalography; Flurothyl; Hemodynamics; Hyperglycemia; Male; Mannitol; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Time Factors; Vacuoles | 1993 |
Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats.
Topics: Animals; Anticonvulsants; Convulsants; Flurothyl; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Male; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Seizures; Substantia Nigra; Vigabatrin | 1994 |
Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal.
Topics: Administration, Inhalation; Aging; Animals; Disease Susceptibility; Emotions; Flurothyl; Glutamates; Glutamic Acid; Handling, Psychological; Learning; Male; Memory; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
The influence of thalamic GABA transmission on the susceptibility of adult rats to flurothyl induced seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Bicuculline; Flurothyl; gamma-Aminobutyric Acid; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission; Thalamic Nuclei; Vigabatrin | 1993 |
MK801 pretreatment reduces kainic acid-induced spontaneous seizures in prepubescent rats.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Electroencephalography; Epilepsy, Tonic-Clonic; Flurothyl; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1993 |
Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice.
Topics: Acoustic Stimulation; Animals; Carbonic Anhydrases; Disease Susceptibility; Epilepsy, Tonic-Clonic; Flurothyl; Mice; Mice, Mutant Strains; Pentylenetetrazole; Reaction Time; Seizures | 1993 |
Developmental changes in seizure susceptibility in carbonic anhydrase II-deficient mice and normal littermates.
Topics: Acoustic Stimulation; Aging; Animals; Animals, Newborn; Carbonic Anhydrases; Disease Susceptibility; Flurothyl; Mice; Reaction Time; Reference Values; Seizures | 1993 |
Differences in c-fos immunoreactivity due to age and mode of seizure induction.
Topics: Aging; Animals; Flurothyl; Hypoxia; Immunohistochemistry; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats; Seizures | 1993 |
Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility.
Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Behavior, Animal; Disease Susceptibility; Electric Stimulation; Flurothyl; Handling, Psychological; Kainic Acid; Kindling, Neurologic; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Convulsants; Epilepsy, Tonic-Clonic; Female; Flurothyl; Hippocampus; Male; Methylazoxymethanol Acetate; Mice; Myoclonus; Pregnancy; Prenatal Exposure Delayed Effects; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Teratogens | 1996 |
Basic fibroblast growth factor is highly neuroprotective against seizure-induced long-term behavioural deficits.
Topics: Aging; Animals; Behavior, Animal; Cognition Disorders; Excitatory Amino Acid Agonists; Fibroblast Growth Factor 2; Flurothyl; Handling, Psychological; Kainic Acid; Learning Disabilities; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 1997 |
An indirect method for absorption rate estimation: flurothyl-induced seizures.
Topics: Absorption; Air; Animals; Convulsants; Flurothyl; Inhalation; Models, Biological; Models, Theoretical; Rats; Seizures; Time Factors | 1997 |
Decreased brainstem seizure thresholds and facilitated seizure propagation in mice exposed to repeated flurothyl-induced generalized forebrain seizures.
Topics: Animals; Brain Stem; Cornea; Disease Models, Animal; Electroshock; Flurothyl; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Olfactory Bulb; Prosencephalon; Seizures | 1998 |
Regional analysis of the spatial patterns of Fos induction in brain following flurothyl kindling.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Central Nervous System Depressants; Central Nervous System Stimulants; Convulsants; Ethanol; Flurothyl; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Phenotype; Proto-Oncogene Proteins c-fos; Seizures | 1998 |
Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Flurothyl; Hypnotics and Sedatives; Male; Microinjections; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Substantia Nigra; Zolpidem | 1998 |
Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility.
Topics: Animals; Convulsants; Disease Susceptibility; Entorhinal Cortex; Epilepsy; Estrogens; Female; Flurothyl; Magnesium; Morphine; Narcotics; Ovariectomy; Pregnancy; Prenatal Exposure Delayed Effects; Progesterone; Rats; Seizures | 1998 |
NMR-based identification of intra- and extracellular compartments of the brain Pi peak.
Topics: Acetates; Animals; Brain; Convulsants; Dogs; Extracellular Space; Flurothyl; Glucose-6-Phosphate; Hydrogen-Ion Concentration; Injections, Intra-Arterial; Intracellular Membranes; Magnetic Resonance Spectroscopy; Microdialysis; Phosphates; Seizures | 1998 |
Consequences of neonatal seizures in the rat: morphological and behavioral effects.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Bromodeoxyuridine; Cell Count; Convulsants; Differential Threshold; Electroencephalography; Electrophysiology; Flurothyl; Maze Learning; Motor Activity; Pentylenetetrazole; Rats; Rats, Wistar; Recurrence; Seizures; Swimming | 1998 |
Region-specific modulation of limbic seizure susceptibility by ovarian steroids.
Topics: Animals; Convulsants; Entorhinal Cortex; Estrogens; Female; Flurothyl; Hippocampus; In Vitro Techniques; Limbic System; Magnesium; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1999 |
Effects of neonatal seizures on subsequent seizure-induced brain injury.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Convulsants; Disease Susceptibility; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Flurothyl; Kainic Acid; Male; Perforant Pathway; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1999 |
Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Convulsants; Flurothyl; Humans; Ketone Bodies; Ketosis; Male; Mice; Mice, Inbred C3H; Seizures; Weight Gain | 1999 |
Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuli.
Topics: Acoustic Stimulation; Animals; Convulsants; Disease Susceptibility; Flurothyl; Mice; Mice, Knockout; Norepinephrine; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures | 1999 |
Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study.
Topics: Animals; Animals, Newborn; Behavior, Animal; Convulsants; Differential Threshold; Electric Stimulation; Electrophysiology; Flurothyl; Hippocampus; Male; Maze Learning; Neural Inhibition; Perforant Pathway; Rats; Rats, Sprague-Dawley; Reference Values; Seizures; Swimming; Time Factors | 1999 |
Flurothyl-induced seizures in rats activate Fos in brainstem catecholaminergic neurons.
Topics: Animals; Convulsants; Dopamine beta-Hydroxylase; Female; Flurothyl; Medulla Oblongata; Neurons; Phenylethanolamine N-Methyltransferase; Pons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Catecholamine; Seizures | 2000 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Flurothyl; Genetic Predisposition to Disease; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Metallothionein 3; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Seizures; Synapses; Synaptic Vesicles; Zinc | 2000 |
Estradiol facilitates kainic acid-induced, but not flurothyl-induced, behavioral seizure activity in adult female rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Estradiol; Female; Flurothyl; Hippocampus; Humans; Kainic Acid; Limbic System; Male; Neural Pathways; Progesterone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Neonatal seizures induced persistent changes in intrinsic properties of CA1 rat hippocampal cells.
Topics: Action Potentials; Administration, Inhalation; Animals; Animals, Newborn; Cell Membrane; Flurothyl; Hippocampus; Male; Membrane Potentials; Pyramidal Cells; Rats; Rats, Wistar; Seizures | 2000 |
Effect of ganaxolone on flurothyl seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Flurothyl; Male; Motor Activity; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Anticonvulsant action and long-term effects of gabapentin in the immature brain.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Flurothyl; Gabapentin; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Kainic Acid; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Seizures; Space Perception | 2001 |
Reduced neurogenesis after neonatal seizures.
Topics: Acidosis; Age Factors; Animals; Animals, Newborn; Brain; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Division; Dentate Gyrus; Disease Models, Animal; Fluorescent Antibody Technique; Flurothyl; Hypercapnia; Hypoxia; Immunohistochemistry; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2001 |
Genetic comparison of seizure control by norepinephrine and neuropeptide Y.
Topics: Animals; Dopamine beta-Hydroxylase; Exercise Test; Flurothyl; Genetic Predisposition to Disease; Handling, Psychological; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Knockout; Neuropeptide Y; Norepinephrine; Pentylenetetrazole; Phenotype; Seizures | 2001 |
Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Female; Flurothyl; Infusion Pumps; Kindling, Neurologic; Microinjections; Muscimol; Rats; Rats, Wistar; Seizures; Substantia Nigra | 2001 |
The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flurothyl; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neural Inhibition; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Synaptic Transmission | 2001 |
Electrical stimulation of substantia nigra pars reticulata is anticonvulsant in adult and young male rats.
Topics: Age Factors; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation Therapy; Electrodes, Implanted; Flurothyl; Male; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Treatment Outcome | 2002 |
Pentylenetetrazol-induced recurrent seizures in rat pups: time course on spatial learning and long-term effects.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Cell Count; Exploratory Behavior; Flurothyl; Maze Learning; Memory; Motor Activity; Neurons; Rats; Recurrence; Seizures; Spatial Behavior; Time Factors | 2002 |
Differential effects of opioids on flurothyl seizure thresholds in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Flurothyl; Male; Meperidine; Narcotics; Pentazocine; Rats; Receptors, Opioid; Seizures | 1979 |
Cerebral energy metabolism during experimental status epilepticus.
Topics: Adenine Nucleotides; Animals; Blood Pressure; Brain; Creatine Kinase; Electroencephalography; Electroshock; Energy Metabolism; Flurothyl; Glucose; Glycogen; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lactates; Male; Mice; NAD; Oxidation-Reduction; Pentylenetetrazole; Phosphocreatine; Rats; Seizures | 1975 |
Brain protein synthesis during neonatal seizures: an experimental study.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Electroencephalography; Evoked Potentials; Flurothyl; Lysine; Nerve Tissue Proteins; Polyribosomes; Rats; Seizures; Status Epilepticus | 1979 |
Classification of opioids on the basis of change in seizure threshold in rats.
Topics: Animals; Drug Tolerance; Flurothyl; Male; Meperidine; Naloxone; Narcotics; Pentazocine; Rats; Seizures; Stereoisomerism | 1979 |
Retrograde enhancement of memory with fluorthyl: Electrophysiological effects in chicks.
Topics: Animals; Animals, Newborn; Brain; Chickens; Dose-Response Relationship, Drug; Electroencephalography; Flurothyl; Memory; Seizures; Stimulation, Chemical | 1977 |
Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A.
Topics: Age Factors; Androstenes; Animals; Animals, Newborn; Anticholesteremic Agents; Cerebral Cortex; Cholesterol; Chronic Disease; Desmosterol; Disease Susceptibility; Flurothyl; Phospholipids; Rats; Seizures | 1978 |
Effect of intracisternal 6-hydroxydopamine on seizure susceptibility in rats.
Topics: Animals; Body Temperature; Brain Chemistry; Electroshock; Flurothyl; Hydroxydopamines; Male; Norepinephrine; Rats; Seizures; Serotonin | 1978 |
Dissociation between the anticonvulsant action of alcohol and its depressant action in mice of different genotypes.
Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Ethanol; Flurothyl; Mice; Mice, Inbred Strains; Pentobarbital; Seizures; Sleep; Species Specificity; Time Factors | 1978 |
Effects of neonatal seizures on ontogeny of reflexes and behavior. An experimental study in the rat.
Topics: Animals; Animals, Newborn; Behavior; Brain; Cholesterol; DNA; Electroshock; Female; Flurothyl; Male; Nerve Tissue Proteins; Rats; Reflex; RNA; Seizures | 1977 |
Mediation of myoclonic seizures by dopamine and clonic seizures by acetylcholine and GABA.
Topics: Animals; Apomorphine; Bicuculline; Dose-Response Relationship, Drug; Flurothyl; Haloperidol; Isoquinolines; Mice; Myoclonus; Pilocarpine; Scopolamine; Seizures | 1977 |
Neutralization of sensory-input modification of seizure thresholds in rats.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Differential Threshold; Flurothyl; Inhibition, Psychological; Male; Photic Stimulation; Rats; Seizures; Time Factors; Visual Perception | 1976 |
Increased CNS sensitivity to flurothyl as a measure of physical dependence in mice following morphine, phenobarbital, and ethanol treatment.
Topics: Animals; Ethanol; Flurothyl; Humans; Male; Mice; Mice, Inbred C57BL; Morphine Dependence; Phenobarbital; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
Effects of neonatal status epilepticus on rat brain development.
Topics: Animals; Animals, Newborn; Bicuculline; Body Weight; Brain; Brain Chemistry; Cerebellum; Cholesterol; DNA; Electroencephalography; Female; Flurothyl; Male; Nerve Tissue Proteins; Organ Size; Rats; RNA; Seizures | 1976 |
Developmental brain damage after chemically induced epileptic seizures.
Topics: Animals; Brain; Brain Chemistry; Brain Damage, Chronic; Cell Count; DNA; Female; Flurothyl; Male; Rats; RNA; Seizures | 1975 |
Alteration of drug pharmacodynamics by hyperlipidemia.
Topics: Animals; Aorta; Blood Pressure; Flurothyl; Hyperlipidemias; Ileum; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Pharmaceutical Preparations; Rabbits; Rats; Seizures; Species Specificity; Sulfamerazine | 1975 |
The effect of convulsions induced by flurothyl on ribonucleic acid synthesis in rat cerebral cortex during the recovery phase.
Topics: Animals; Cell Nucleus; Cerebral Cortex; Cytoplasm; DNA; Female; Flurothyl; Rats; RNA; Seizures; Time Factors | 1975 |
Effects of testing age and fostering experience on seizure susceptibility of rats treated prenatally with chlorpromazine.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Chlorpromazine; Differential Threshold; Female; Flurothyl; Gestational Age; Litter Size; Male; Maternal-Fetal Exchange; Pregnancy; Rats; Reaction Time; Seizures; Sex Factors | 1975 |
Methaqualone: tolerance and physical dependence in mice.
Topics: Animals; Drug Tolerance; Flurothyl; Humans; Male; Methaqualone; Mice; Mice, Inbred C57BL; Myoclonus; Reaction Time; Seizures; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
Memory performance after flurothyl treatment in rainbow trout.
Topics: Animals; Avoidance Learning; Carbon Dioxide; Electroshock; Flurothyl; Memory; Retention, Psychology; Salmonidae; Seizures; Temperature; Trout | 1976 |
The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Infusions, Parenteral; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Substantia Nigra | 1992 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flurothyl; gamma-Aminobutyric Acid; Muscimol; Rats; Receptors, GABA-A; Seizures; Status Epilepticus; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission | 1992 |
Neurochemical effects of electrically and chemically induced seizures: an in vivo microdialysis study in the rat hippocampus.
Topics: Acetylcholine; Analysis of Variance; Animals; Dialysis; Electroshock; Flurothyl; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Rats; Rats, Wistar; Seizures; Serotonin | 1992 |
Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures.
Topics: Aging; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Electrodes; Electroencephalography; Flurothyl; Kainic Acid; Male; Myoclonus; Rats; Rats, Inbred Strains; Recurrence; Seizures; Status Epilepticus | 1992 |
Effects of substantia nigra gamma-vinyl-GABA infusions on flurothyl seizures in adult rats.
Topics: Aminocaproates; Analysis of Variance; Animals; Anticonvulsants; Flurothyl; Infusions, Parenteral; Male; Muscimol; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Vigabatrin | 1991 |
Evidence for the involvement of nigral GABAB receptors in seizures of rat pups.
Topics: Age Factors; Animals; Baclofen; Flurothyl; Rats; Receptors, GABA-A; Seizures; Substantia Nigra | 1989 |
Seizure-induced damage in the substantia nigra pars reticulata: lesions in the frontal cortex prior to the seizure period mitigate the damage.
Topics: Amino Acids; Animals; Energy Metabolism; Flurothyl; Frontal Lobe; Male; Necrosis; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra | 1989 |
Dynorphin A (1-13): in vivo opioid antagonist actions and non-opioid anticonvulsant effects in the rat flurothyl test.
Topics: Animals; Anticonvulsants; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Flurothyl; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Seizures | 1986 |
Ventromedial thalamic lesions and seizure susceptibility.
Topics: Animals; Disease Susceptibility; Flurothyl; gamma-Aminobutyric Acid; Male; Neural Pathways; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Synaptic Transmission; Thalamic Nuclei | 1985 |
U50,488, a highly selective kappa opioid: anticonvulsant profile in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Flurothyl; Male; Phenytoin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1986 |
Genetic influences on GABA-related seizures.
Topics: 3-Mercaptopropionic Acid; Animals; Female; Flurothyl; gamma-Aminobutyric Acid; Genetics, Behavioral; Male; Mice; Mice, Inbred Strains; Muscimol; Receptors, GABA-A; Seizures; Species Specificity | 1986 |
In vivo interactions among opiate receptor agonists and antagonists.
Topics: Animals; Anticonvulsants; Corpus Striatum; Cyclic AMP; Endorphins; Flurothyl; Hypertension; Narcotics; Receptors, Opioid; Seizures; Shock, Septic | 1986 |
Flurothyl seizure thresholds associated with acute and chronic chlordiazepoxide dependence and withdrawal.
Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Flurothyl; Male; Rats; Rats, Inbred Strains; Seizures | 1988 |
Administration of aspartame potentiates pentylenetetrazole- and fluorothyl-induced seizures in mice.
Topics: Animals; Aspartame; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Male; Mice; Pentylenetetrazole; Phenylalanine; Seizures; Tyrosine | 1988 |
Age-related differences in seizure susceptibility to flurothyl.
Topics: Age Factors; Aging; Animals; Flurothyl; Male; Rats; Rats, Inbred Strains; Seizures | 1988 |
Mutual interactions between repeated flurothyl convulsions and electrical kindling.
Topics: Amygdala; Animals; Cerebral Cortex; Flurothyl; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Reaction Time; Seizures | 1987 |
Differential convulsive susceptibility of high-activity and low-activity selected mice in response to GABA antagonists.
Topics: Animals; Behavior, Animal; Bicuculline; Female; Flurothyl; GABA Antagonists; Male; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1987 |
Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion.
Topics: Animals; Brain; Cerebral Cortex; Depression, Chemical; Electroshock; Flurothyl; gamma-Aminobutyric Acid; Kinetics; Male; Potassium; Rats; Rats, Inbred Strains; Seizures | 1987 |
Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion.
Topics: Aminooxyacetic Acid; Animals; Brain; Flurothyl; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamate Decarboxylase; Kinetics; Male; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1987 |
Flurothyl seizure thresholds in mice treated neonatally with a single injection of monosodium glutamate (MSG): evaluation of experimental parameters in flurothyl seizure testing.
Topics: Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Flurothyl; Glutamates; Male; Mice; Mice, Inbred Strains; Naloxone; Organ Size; Seizures; Sodium Glutamate; Temperature | 1987 |
Acetylcholinesterase activity in regions of the rat brain following a convulsion.
Topics: Acetylcholinesterase; Animals; Brain; Electroshock; Female; Flurothyl; Rats; Rats, Inbred Strains; Seizures; Time Factors; Tissue Distribution | 1986 |
The effect of naloxone administration on pregnancy-associated seizures.
Topics: Animals; Endorphins; Female; Flurothyl; Male; Mice; Mice, Inbred C3H; Naloxone; Pregnancy; Pregnancy Complications; Seizures | 1986 |
Genetic influence on increased seizure susceptibility in pregnancy.
Topics: Animals; Disease Susceptibility; Female; Flurothyl; Genes; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred Strains; Myoclonus; Pregnancy; Pregnancy Complications; Seizures | 1986 |
Extra- and intracellular pH in the brain during seizures and in the recovery period following the arrest of seizure activity.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Brain; Extracellular Space; Flurothyl; Hypoxia; Intracellular Fluid; Lactates; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Seizures | 1985 |
Cerebral metabolic changes during and following fluorothyl-induced seizures in ventilated rats.
Topics: Adenine Nucleotides; Animals; Blood Glucose; Brain; Cerebral Cortex; Convulsants; Flurothyl; Hippocampus; Hydrogen-Ion Concentration; Male; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains; Seizures | 1985 |
Unidirectional interaction between flurothyl seizures and amygdala kindling.
Topics: Amygdala; Animals; Disease Susceptibility; Electric Stimulation; Flurothyl; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Seizures | 1985 |
Metabolic effects of seizures.
Topics: Acidosis; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bicarbonates; Blood Flow Velocity; Brain; Carbon Dioxide; Cats; Cerebrovascular Circulation; Dogs; Electric Stimulation; Energy Metabolism; Epilepsy; Flurothyl; Hydrogen-Ion Concentration; Lactates; Mice; NAD; Oxygen; Oxygen Consumption; Pentylenetetrazole; Phosphocreatine; Pyruvates; Rats; Seizures | 1974 |
Intermodal interaction: effect of sensory stimulation on flurothyl seizure threshold in normal and brain-damaged rats.
Topics: Acoustic Stimulation; Animals; Flurothyl; Male; Photic Stimulation; Rats; Rats, Inbred Strains; Seizures; Visual Cortex | 1974 |
Cerebellar cortical degeneration due to acute azide poisoning.
Topics: Animals; Azides; Cerebellar Ataxia; Cerebellar Cortex; Cerebral Decortication; Disease Models, Animal; Dose-Response Relationship, Drug; Flurothyl; Haplorhini; Macaca; Respiration, Artificial; Seizures; Succinylcholine; Thiamylal | 1972 |
Permanent reduction in seizure threshold resulting from repeated electrical stimulation.
Topics: Animals; Brain; Electric Stimulation; Electrodes, Implanted; Flurothyl; Hypothalamus; Male; Rats; Seizures; Septum Pellucidum | 1972 |
Plasma fibrinolytic activity associated with flurothyl induced convulsion.
Topics: Animals; Asphyxia; Blood Coagulation; Blood Coagulation Tests; Fibrinolysis; Flurothyl; Oxygen; Paralysis; Prothrombin; Prothrombin Time; Rats; Respiration, Artificial; Seizures; Serum Globulins | 1972 |
Folate metabolism and the anticonvulsant efficacy of phenobarbital.
Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital; Rats; Seizures; Vitamin B 12 | 1973 |
Retroactive facilitation of memory in goldfish by flurothyl.
Topics: Amnesia; Animals; Avoidance Learning; Carbon Dioxide; Cyprinidae; Dose-Response Relationship, Drug; Flurothyl; Humans; Memory; Seizures; Temperature; Time Factors | 1973 |
Seizure susceptibility and avoidance conditioning in adult rats treated prenatally with chlorpromazine.
Topics: Age Factors; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Chlorpromazine; Electroshock; Female; Fetus; Flurothyl; Humans; Male; Maternal Behavior; Maternal-Fetal Exchange; Motor Activity; Pregnancy; Rats; Reaction Time; Seizures; Sex Factors; Stress, Psychological | 1974 |
Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats.
Topics: Animals; Behavior, Animal; Body Weight; Flurothyl; Humans; Male; Morphine Dependence; Nalorphine; Rats; Seizures; Substance Withdrawal Syndrome; Time Factors | 1974 |