flurogestone-acetate and Glaucoma

To evaluate the results of elevated intraocular pressure (IO) secondary to dropping of 0.1% Dexamethasone, Fluorometholone and Florex for 1-3 months after photorefractive keratectomy, we summed up and analysed the 3-month follow-up data on 546 eyes in three groups. The rates of IO elevated in Dexamethasone, Fluorometholone and Florex were 36%, 12.4% and 31.9% respectively. After topical use of corticosteroid, some of the elevations of IO took place as early as two weeks, but most of them occurred around 1 month. Eleven patients with IO elevation of both eyes had visual acuity decreased associated with eye-ache and halos and the other patients had no symptoms. After discontinuation of corticosteroid and institution of antiglaucoma therapy, the IO became normal in 3-7 days. In practice, this means that patients receiving corticosteroid eyedrops for more than two weeks should be checked for the possibility of ocular hypertension to prevent the corticosteroid glaucoma.

Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Dexamethasone; Female; Fluorometholone; Flurogestone Acetate; Follow-Up Studies; Glaucoma; Glucocorticoids; Humans; Intraocular Pressure; Lasers, Excimer; Male; Middle Aged; Ophthalmic Solutions; Photorefractive Keratectomy; Postoperative Care