flurbiprofen has been researched along with Rheumatoid Arthritis in 67 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Excerpt | Relevance | Reference |
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"The effects of three non-steroidal anti-inflammatory drugs (NSAIDs) on the pharmacokinetics of methotrexate were studied in 10 patients with rheumatoid arthritis." | 9.07 | Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis. ( Bradley, JD; Brater, DC; Greene, PK; Tracy, TS; Worster, T, 1994) |
"This large-scale, double-blind study compared 200 mg per day of flurbiprofen (Ansaid, Upjohn) with 4,000 mg per day of aspirin in 822 patients with definite or classical rheumatoid arthritis who were evaluated for up to 52 weeks." | 9.06 | Flurbiprofen in the treatment of rheumatoid arthritis. A comparison with aspirin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
"A total daily dose of 200 mg of flurbiprofen (Ansaid, Upjohn) was administered either twice daily (100 mg BID) or four times daily (50 mg QID) to 143 patients with rheumatoid arthritis." | 9.06 | Comparison of two dosing schedules of flurbiprofen for patients with rheumatoid arthritis. Twice-daily versus four-times-a-day schedules. ( Brown, BL; Daenzer, CL; Hearron, MS; Johnson, JH, 1986) |
"The efficacy and safety of flurbiprofen (Ansaid, Upjohn), 100 mg twice daily, were compared with those of naproxen, 250 mg twice daily, in a six-week, double-blind, randomized study involving 133 patients with rheumatoid arthritis." | 9.06 | Flurbiprofen versus naproxen in the treatment of rheumatoid arthritis. ( Brown, BL; Johnson, JH; Stiger, TR, 1986) |
"Eight hundred and forty-two patients undergoing treatment for rheumatoid arthritis in hospital centres in the United Kingdom were evaluated as part of a long-term, variable dose study of the efficacy and safety of flurbiprofen in 1,396 patients with a variety of rheumatological disorders." | 9.06 | A long-term study of flurbiprofen in rheumatological disorders: I. Rheumatoid arthritis. ( Busson, M, 1986) |
"A 6-week double-blind, parallel controlled, randomized study was carried out to compare the efficacy and tolerability of 100 mg flurbiprofen twice daily with 375 mg naproxen twice daily in patients with rheumatoid arthritis." | 9.06 | A comparison of flurbiprofen and naproxen in the treatment of rheumatoid arthritis: a Canadian multi-centre study. ( Atkinson, MH; Buchanan, WW; Fitzgerald, AA; Lussier, A; Tannenbaum, HH, 1990) |
"One-hundred and eighteen patients with rheumatoid arthritis were treated for 4 weeks with flurbiprofen 300 mg/day (sixty patients) or naproxen 750 mg/day (fifty-eight patients) in a six-centre randomized trial." | 9.05 | A multicentre comparison of flurbiprofen and naproxen in rheumatoid arthritis: a four-week study in 118 patients. ( Cherie-Ligniere, G; Colamussi, V; Cozzolongo, AC; Frizziero, L; Loizzi, P; Mattara, L; Zorzin, L, 1983) |
"Forty patients with definite or classical rheumatoid arthritis were entered for 3 months in a double-blind trial, 20 patients each on 200 mg flurbiprofen or 4." | 9.05 | Treatment of rheumatoid arthritis with flurbiprofen: a comparison with enteric-coated aspirin. ( Dequeker, J; Mardjuardi, A, 1981) |
"1 Seventeen patients with rheumatoid arthritis were studied in a double-blind crossover trial contrasting three different times of administration of twice-daily flurbiprofen." | 9.05 | Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeutic effectiveness of flurbiprofen at different times of day. ( Knapp, MS; Kowanko, IC; Mahoney, PG; Pownall, R; Swannell, AJ, 1981) |
"Preliminary results are reported for the first 23 rheumatoid arthritis patients entered in a long-term, double-blind trial to compare the efficacy of flurbiprofen and indomethacin." | 9.04 | A comparative study of the long-term efficacy of flurbiprofen and indomethacin in the treatment of rheumatoid arthritis, with special reference to iron metabolism. ( Bulgen, DY; Hazleman, BL, 1977) |
"Preliminary results in 12 patients with rheumatoid arthritis are presented from an on-going double-blind, between patient comparison of flurbiprofen and phenylbutazone." | 9.04 | Controlled clinical trial comparing flurbiprofen and phenylbutazone in patients with rheumatoid arthritis. ( Di Mummo, O; Ferri, S; Franco, PA, 1977) |
"Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis." | 9.04 | Flurbiprofen in rheumatoid arthritis therapy. ( Loizzi, P; Numo, R; Pipitone, V, 1977) |
"A double-blind crossover study was carried out in 30 patients with rheumatoid arthritis to compare the effectiveness of 300 mg flurbiprofen daily with that of 150 mg indomethacin daily." | 9.04 | Flurbiprofen and indomethacin in the treatment of rheumatoid arthritis: a double-blind crossover study. ( Kruger, HH, 1977) |
"A double-blind crossover trial of 200 mg flurbiprofen daily and 100 mg indomethacin daily, each given for 2 weeks separated by a 1-week placebo washout period, was carried out in 30 patients with rheumatoid arthritis." | 9.04 | A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. ( Siegmeth, W, 1977) |
"Flurbiprofen and ibuprofen were compared in a six-week double-blind randomized study in 208 patients with rheumatoid arthritis." | 9.04 | Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen. ( Briney, WG; Giansiracusa, J; Mena, HR; Ward, JR; Wolski, KP; Zuckner, J, 1977) |
"A double-blind, crossover study was carried out in 30 patients with active, classical or definite rheumatoid arthritis to compare the effect of 200 mg flurbiprofen per day with that of 100 mg indomethacin per day." | 9.04 | A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. ( Brewis, ID, 1977) |
"This meta-analysis has shown that flurbiprofen is an interesting alternative to commonly prescribed NSAIDs in the symptomatic management of rheumatoid arthritis, especially given its favourable efficacy/tolerance ratio." | 8.84 | Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. ( Mawet, A; Rabenda, V; Reginster, JY; Richy, F, 2007) |
"Flurbiprofen, a phenylalkanoic acid derivative, is a non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions." | 8.76 | Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1979) |
"The safety of flurbiprofen (Ansaid, Upjohn) was assessed after pooling data on kidney and liver function collected from nine separate phase III clinical trials involving 1,677 patients (941 receiving flurbiprofen and 736 receiving comparison drugs) with ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis." | 7.67 | Safety of flurbiprofen in the treatment of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. A summary of liver and kidney assay data. ( Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
" A clinical trial was conducted with flurbiprofen 100 mg three times a day by mouth in rheumatoid arthritis to determine variability in response." | 7.67 | Variability in response to nonsteroidal anti-inflammatory analgesics: evidence from controlled clinical therapeutic trial of flurbiprofen in rheumatoid arthritis. ( Arnold, MH; Beller, EM; Brooks, PM; Buchanan, WW; Preston, SJ, 1988) |
"The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA)." | 7.66 | Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis. ( Ohuchi, K; Rikimaru, A; Tokunaga, M; Tsurufuji, S; Wakamatsu, E; Yoshizawa, S, 1981) |
" Only minor differences in the pharmacokinetic parameters were observed between the younger and elderly patients." | 6.67 | The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis. ( Antal, EJ; Buchanan, WW; Cauvier, H; Grace, EM; Kean, WF; Rischke, J, 1992) |
"Forty patients with classic or definite rheumatoid arthritis were entered into a double-blind, randomized, multiple crossover, sequential trial comparing two doses (300 mg vs 150 mg per day) and two dosing schedules (b." | 6.66 | A comparative analysis of two dosing strategies of flurbiprofen in rheumatoid arthritis: an application of sequential trial design. ( Bellamy, N; Kreeft, JH, 1988) |
" Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios were small." | 5.28 | The pharmacokinetics of the enantiomers of flurbiprofen in patients with rheumatoid arthritis. ( Aarons, L; Toon, S; Young, MA, 1991) |
"Flurbiprofen was better tolerated (p less than 0." | 5.27 | Steroid-sparing action of flurbiprofen and indomethacin in rheumatoid arthritis: a nine-week study. ( Benvenuti, C; Longoni, A; Viara, M, 1983) |
"Flurbiprofen (Froben) was assumed to be a causal drug based on a clinical course and a positive result of lymphocyte transformation test." | 5.27 | A case of acute interstitial nephritis induced by flurbiprofen. ( Hara, M; Ikezaki, N; Ito, J; Kuwahara, K; Nakayama, M; Sato, T; Tazoe, N, 1987) |
"The effects of three non-steroidal anti-inflammatory drugs (NSAIDs) on the pharmacokinetics of methotrexate were studied in 10 patients with rheumatoid arthritis." | 5.07 | Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis. ( Bradley, JD; Brater, DC; Greene, PK; Tracy, TS; Worster, T, 1994) |
"A total daily dose of 200 mg of flurbiprofen (Ansaid, Upjohn) was administered either twice daily (100 mg BID) or four times daily (50 mg QID) to 143 patients with rheumatoid arthritis." | 5.06 | Comparison of two dosing schedules of flurbiprofen for patients with rheumatoid arthritis. Twice-daily versus four-times-a-day schedules. ( Brown, BL; Daenzer, CL; Hearron, MS; Johnson, JH, 1986) |
"This large-scale, double-blind study compared 200 mg per day of flurbiprofen (Ansaid, Upjohn) with 4,000 mg per day of aspirin in 822 patients with definite or classical rheumatoid arthritis who were evaluated for up to 52 weeks." | 5.06 | Flurbiprofen in the treatment of rheumatoid arthritis. A comparison with aspirin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
"A 6-week double-blind, parallel controlled, randomized study was carried out to compare the efficacy and tolerability of 100 mg flurbiprofen twice daily with 375 mg naproxen twice daily in patients with rheumatoid arthritis." | 5.06 | A comparison of flurbiprofen and naproxen in the treatment of rheumatoid arthritis: a Canadian multi-centre study. ( Atkinson, MH; Buchanan, WW; Fitzgerald, AA; Lussier, A; Tannenbaum, HH, 1990) |
"The efficacy and safety of flurbiprofen (Ansaid, Upjohn), 100 mg twice daily, were compared with those of naproxen, 250 mg twice daily, in a six-week, double-blind, randomized study involving 133 patients with rheumatoid arthritis." | 5.06 | Flurbiprofen versus naproxen in the treatment of rheumatoid arthritis. ( Brown, BL; Johnson, JH; Stiger, TR, 1986) |
"Eight hundred and forty-two patients undergoing treatment for rheumatoid arthritis in hospital centres in the United Kingdom were evaluated as part of a long-term, variable dose study of the efficacy and safety of flurbiprofen in 1,396 patients with a variety of rheumatological disorders." | 5.06 | A long-term study of flurbiprofen in rheumatological disorders: I. Rheumatoid arthritis. ( Busson, M, 1986) |
"One-hundred and eighteen patients with rheumatoid arthritis were treated for 4 weeks with flurbiprofen 300 mg/day (sixty patients) or naproxen 750 mg/day (fifty-eight patients) in a six-centre randomized trial." | 5.05 | A multicentre comparison of flurbiprofen and naproxen in rheumatoid arthritis: a four-week study in 118 patients. ( Cherie-Ligniere, G; Colamussi, V; Cozzolongo, AC; Frizziero, L; Loizzi, P; Mattara, L; Zorzin, L, 1983) |
"Forty patients with definite or classical rheumatoid arthritis were entered for 3 months in a double-blind trial, 20 patients each on 200 mg flurbiprofen or 4." | 5.05 | Treatment of rheumatoid arthritis with flurbiprofen: a comparison with enteric-coated aspirin. ( Dequeker, J; Mardjuardi, A, 1981) |
"1 Seventeen patients with rheumatoid arthritis were studied in a double-blind crossover trial contrasting three different times of administration of twice-daily flurbiprofen." | 5.05 | Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeutic effectiveness of flurbiprofen at different times of day. ( Knapp, MS; Kowanko, IC; Mahoney, PG; Pownall, R; Swannell, AJ, 1981) |
"Forty patients with osteoarthrosis or rheumatoid arthritis were entered in a 4-week double-blind trial to compare the efficacy, safety and tolerance of a flurbiprofen 100 mg suppository formulation with indomethacin 100 mg suppositories." | 5.05 | A double-blind comparison of flurbiprofen and indomethacin suppositories in the treatment of osteoarthrosis and rheumatoid disease. ( De Moor, M; Ooghe, R, 1981) |
"A double-blind crossover study was carried out in 30 patients with rheumatoid arthritis to compare the effectiveness of 300 mg flurbiprofen daily with that of 150 mg indomethacin daily." | 5.04 | Flurbiprofen and indomethacin in the treatment of rheumatoid arthritis: a double-blind crossover study. ( Kruger, HH, 1977) |
"Flurbiprofen and ibuprofen were compared in a six-week double-blind randomized study in 208 patients with rheumatoid arthritis." | 5.04 | Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen. ( Briney, WG; Giansiracusa, J; Mena, HR; Ward, JR; Wolski, KP; Zuckner, J, 1977) |
"A double-blind placebo controlled trial was carried out in 14 steroid-dependent patients with rheumatoid arthritis to assess the effectiveness and steroid-sparing action of flurbiprofen over a 4-week period." | 5.04 | Steroid-sparing action of flurbiprofen: use of an additional parameter of joint scans with 99m technetium. ( Desai, MM; Joshi, VR; Lele, RD; Nagarwala, HK; Pispati, PK; Virani, AR, 1977) |
"Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis." | 5.04 | Flurbiprofen in rheumatoid arthritis therapy. ( Loizzi, P; Numo, R; Pipitone, V, 1977) |
"Fifteen patients with seropositive rheumatoid arthritis were treated for 2-weeks periods with 150 mg flurbiprofen daily and with flubriprofen in the same dosage plus 3 g aspirin daily, the treatments being administered in random allocation." | 5.04 | Flurbiprofen-aspirin interaction: a double-blind crossover study. ( Brooks, PM; Khong, TK, 1977) |
"1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment." | 5.04 | Continued use of non-steroidal anti-inflammatory drugs: an index of clinical efficacy. ( Buchanan, WW; Capell, HA; Dick, WC; Paterson, S; Rooney, PJ, 1978) |
"A double-blind crossover trial of 200 mg flurbiprofen daily and 100 mg indomethacin daily, each given for 2 weeks separated by a 1-week placebo washout period, was carried out in 30 patients with rheumatoid arthritis." | 5.04 | A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. ( Siegmeth, W, 1977) |
"Preliminary results are reported for the first 23 rheumatoid arthritis patients entered in a long-term, double-blind trial to compare the efficacy of flurbiprofen and indomethacin." | 5.04 | A comparative study of the long-term efficacy of flurbiprofen and indomethacin in the treatment of rheumatoid arthritis, with special reference to iron metabolism. ( Bulgen, DY; Hazleman, BL, 1977) |
"Preliminary results in 12 patients with rheumatoid arthritis are presented from an on-going double-blind, between patient comparison of flurbiprofen and phenylbutazone." | 5.04 | Controlled clinical trial comparing flurbiprofen and phenylbutazone in patients with rheumatoid arthritis. ( Di Mummo, O; Ferri, S; Franco, PA, 1977) |
"Three double-blind crossover trials were used to study the effects of single doses of flurbiprofen at night on pain at night, duration of morning stiffness and sleep disturbance in patients with active rheumatoid arthritis." | 5.04 | Flurbiprofen at night. ( Boyle, S; Huskisson, EC; Patrick, M; Scott, PJ, 1977) |
"A double-blind, crossover study was carried out in 30 patients with active, classical or definite rheumatoid arthritis to compare the effect of 200 mg flurbiprofen per day with that of 100 mg indomethacin per day." | 5.04 | A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. ( Brewis, ID, 1977) |
"This meta-analysis has shown that flurbiprofen is an interesting alternative to commonly prescribed NSAIDs in the symptomatic management of rheumatoid arthritis, especially given its favourable efficacy/tolerance ratio." | 4.84 | Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. ( Mawet, A; Rabenda, V; Reginster, JY; Richy, F, 2007) |
"Flurbiprofen, a phenylalkanoic acid derivative, is a non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions." | 4.76 | Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1979) |
" Two hundred patients presenting with classic rheumatic diseases (osteoarthritis, n = 50; rheumatoid arthritis, n = 130; ankylosing spondylitis, n = 20) were given a daily dose of 200 mg sustained-release flurbiprofen (flurbiprofen SR)." | 3.70 | Six-month prospective study to monitor the treatment of rheumatic diseases with sustained-release flurbiprofen. ( Miceková, D; Rovenský, J, 2000) |
"Low dose methotrexate (MTX) is widely used in the treatment of rheumatoid arthritis." | 3.68 | Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis. ( Coates, J; Friedman, H; Jamali, F; Russell, AS; Skeith, KJ, 1990) |
"Steady state plasma and synovial fluid flurbiprofen concentrations obtained from 26 rheumatoid arthritis patients receiving 100 mg of flurbiprofen b." | 3.68 | The kinetics of flurbiprofen in synovial fluid. ( Aarons, L, 1991) |
" Flurbiprofen (Ansaid) is a new NSAID for the treatment of rheumatoid arthritis and osteoarthritis." | 3.68 | Nonsteroidal antiinflammatory drug desensitization using flurbiprofen (Ansaid) ( Brown, JS; Douglas, DM; Ward, L, 1993) |
" A clinical trial was conducted with flurbiprofen 100 mg three times a day by mouth in rheumatoid arthritis to determine variability in response." | 3.67 | Variability in response to nonsteroidal anti-inflammatory analgesics: evidence from controlled clinical therapeutic trial of flurbiprofen in rheumatoid arthritis. ( Arnold, MH; Beller, EM; Brooks, PM; Buchanan, WW; Preston, SJ, 1988) |
"The safety of flurbiprofen (Ansaid, Upjohn) was assessed after pooling data on kidney and liver function collected from nine separate phase III clinical trials involving 1,677 patients (941 receiving flurbiprofen and 736 receiving comparison drugs) with ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis." | 3.67 | Safety of flurbiprofen in the treatment of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. A summary of liver and kidney assay data. ( Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
"The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA)." | 3.66 | Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis. ( Ohuchi, K; Rikimaru, A; Tokunaga, M; Tsurufuji, S; Wakamatsu, E; Yoshizawa, S, 1981) |
"Data from 58 premarketing studies of the nonsteroidal antiinflammatory drug flurbiprofen were pooled for analyses of adverse drug reactions (ADRs)." | 2.67 | Clinical safety of flurbiprofen. ( Assenzo, JR; Brooks, CD; Defesche, CL; Johnson, JH; Linet, OI; Schellenberg, D; Teoh, KW; Turner, LF, 1990) |
" Only minor differences in the pharmacokinetic parameters were observed between the younger and elderly patients." | 2.67 | The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis. ( Antal, EJ; Buchanan, WW; Cauvier, H; Grace, EM; Kean, WF; Rischke, J, 1992) |
"Forty patients with classic or definite rheumatoid arthritis were entered into a double-blind, randomized, multiple crossover, sequential trial comparing two doses (300 mg vs 150 mg per day) and two dosing schedules (b." | 2.66 | A comparative analysis of two dosing strategies of flurbiprofen in rheumatoid arthritis: an application of sequential trial design. ( Bellamy, N; Kreeft, JH, 1988) |
"Ibuprofen was selected from this large group." | 2.38 | The propionic acids: a personal perspective. ( Adams, SS, 1992) |
" Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios were small." | 1.28 | The pharmacokinetics of the enantiomers of flurbiprofen in patients with rheumatoid arthritis. ( Aarons, L; Toon, S; Young, MA, 1991) |
" These results were compared with each other and with computer predicted data obtained from dosing with 200 mg conventional flurbiprofen (as 100 mg b." | 1.28 | A multiple dose pharmacokinetic and tolerance study of once daily 200 mg sustained-release flurbiprofen capsules in young and very elderly patients. ( Bird, A; Hamdy, RC; Hill, J; Hind, ID; Le Gallez, P, 1990) |
"Flurbiprofen was better tolerated (p less than 0." | 1.27 | Steroid-sparing action of flurbiprofen and indomethacin in rheumatoid arthritis: a nine-week study. ( Benvenuti, C; Longoni, A; Viara, M, 1983) |
"Flurbiprofen (Froben) was assumed to be a causal drug based on a clinical course and a positive result of lymphocyte transformation test." | 1.27 | A case of acute interstitial nephritis induced by flurbiprofen. ( Hara, M; Ikezaki, N; Ito, J; Kuwahara, K; Nakayama, M; Sato, T; Tazoe, N, 1987) |
"Flurbiprofen has been shown to be effective in relieving symptoms in the degenerative and inflammatory arthritides and side-effects have not proved a problem." | 1.26 | A long-term assessment of flurbiprofen. ( Marsh, BD; Sheldrake, FE; Webber, JM, 1977) |
" The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid." | 1.25 | Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 53 (79.10) | 18.7374 |
1990's | 11 (16.42) | 18.2507 |
2000's | 2 (2.99) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (1.49) | 2.80 |
Authors | Studies |
---|---|
Khan, D | 1 |
Qindeel, M | 1 |
Ahmed, N | 1 |
Khan, AU | 1 |
Khan, S | 1 |
Rehman, AU | 1 |
Richy, F | 1 |
Rabenda, V | 1 |
Mawet, A | 1 |
Reginster, JY | 1 |
Alinovi, A | 1 |
Benoldi, D | 1 |
Manganelli, P | 1 |
Cherie-Ligniere, G | 1 |
Colamussi, V | 1 |
Cozzolongo, AC | 1 |
Loizzi, P | 2 |
Frizziero, L | 1 |
Mattara, L | 1 |
Zorzin, L | 1 |
Swannell, AJ | 2 |
Viara, M | 1 |
Benvenuti, C | 1 |
Longoni, A | 1 |
Yeung Laiwah, AC | 1 |
Hilditch, TE | 1 |
Horton, PW | 1 |
Hunter, JA | 2 |
Dequeker, J | 1 |
Mardjuardi, A | 1 |
De Moor, M | 1 |
Ooghe, R | 1 |
Rudge, SR | 1 |
Lloyd-Jones, JK | 1 |
Hind, ID | 2 |
Gulati, PD | 1 |
Sharma, RK | 1 |
Sood, KC | 1 |
Rizvi, SN | 1 |
Pavelka, K | 1 |
Susta, A | 1 |
Kowanko, IC | 1 |
Pownall, R | 2 |
Knapp, MS | 1 |
Mahoney, PG | 1 |
Tokunaga, M | 1 |
Ohuchi, K | 1 |
Yoshizawa, S | 1 |
Tsurufuji, S | 1 |
Rikimaru, A | 1 |
Wakamatsu, E | 1 |
Tracy, TS | 1 |
Worster, T | 1 |
Bradley, JD | 1 |
Greene, PK | 1 |
Brater, DC | 1 |
Douglas, DM | 1 |
Ward, L | 1 |
Brown, JS | 1 |
Rovenský, J | 1 |
Miceková, D | 1 |
Crook, D | 2 |
Collins, AJ | 1 |
Rose, AJ | 1 |
Lee, P | 2 |
Anderson, JA | 2 |
Miller, J | 2 |
Webb, J | 2 |
Buchanan, WW | 7 |
Sheldrake, FE | 1 |
Webber, JM | 1 |
Marsh, BD | 1 |
Brooks, PM | 2 |
Khong, TK | 1 |
Siegmeth, W | 1 |
Huskisson, EC | 1 |
Scott, PJ | 1 |
Boyle, S | 1 |
Patrick, M | 1 |
Cardoe, N | 2 |
Collins, A, | 1 |
Mena, HR | 1 |
Ward, JR | 1 |
Zuckner, J | 1 |
Wolski, KP | 1 |
Briney, WG | 1 |
Giansiracusa, J | 1 |
Joshi, VR | 1 |
Lele, RD | 1 |
Virani, AR | 1 |
Nagarwala, HK | 1 |
Pispati, PK | 1 |
Desai, MM | 1 |
Brewis, ID | 1 |
Hazleman, BL | 1 |
Bulgen, DY | 1 |
Franco, PA | 1 |
Ferri, S | 1 |
Di Mummo, O | 1 |
Kruger, HH | 1 |
Rooney, PJ | 1 |
Capell, HA | 2 |
Paterson, S | 1 |
Dick, WC | 1 |
Stephens, WH | 1 |
El-Ghobarey, AF | 1 |
Macleod, MM | 1 |
Brogden, RN | 1 |
Heel, RC | 1 |
Speight, TM | 1 |
Avery, GS | 1 |
Bhasin, RC | 1 |
Bhuttani, P | 1 |
Krishnan, CV | 1 |
Sachdev, S | 1 |
de-Silva, M | 1 |
Glass, RC | 1 |
Risdall, PC | 1 |
Pipitone, V | 1 |
Numo, R | 1 |
Adams, SS | 2 |
McCullough, KF | 1 |
Nicholson, JS | 1 |
Takase, K | 1 |
Masumoto, S | 1 |
Okumura, M | 1 |
Moreland, LW | 1 |
Reddy, MS | 1 |
Koopman, WJ | 1 |
Webber, RL | 1 |
Alarcón, GS | 1 |
Jeffcoat, MK | 1 |
Kean, WF | 1 |
Antal, EJ | 1 |
Grace, EM | 1 |
Cauvier, H | 1 |
Rischke, J | 1 |
Aarons, L | 3 |
Young, MA | 1 |
Toon, S | 1 |
Brooks, CD | 1 |
Linet, OI | 1 |
Schellenberg, D | 1 |
Turner, LF | 3 |
Defesche, CL | 1 |
Teoh, KW | 1 |
Johnson, JH | 3 |
Assenzo, JR | 1 |
Atkinson, MH | 1 |
Fitzgerald, AA | 1 |
Lussier, A | 1 |
Tannenbaum, HH | 1 |
Skeith, KJ | 1 |
Russell, AS | 1 |
Jamali, F | 1 |
Coates, J | 1 |
Friedman, H | 1 |
Hamdy, RC | 1 |
Bird, A | 1 |
Le Gallez, P | 1 |
Hill, J | 1 |
Perepel'chenko, AI | 1 |
Borisiuk, BE | 1 |
Bulakh, EP | 1 |
Levin, IV | 1 |
Ternovoĭ, NK | 1 |
Bellamy, N | 1 |
Kreeft, JH | 1 |
Di Matteo, L | 1 |
Evangelista, L | 1 |
Bosica, D | 1 |
Renzetti, A | 1 |
D'Incecco, V | 1 |
Consoli, G | 1 |
Preston, SJ | 1 |
Arnold, MH | 1 |
Beller, EM | 1 |
Busson, M | 1 |
Brown, BL | 2 |
Stiger, TR | 1 |
Daenzer, CL | 1 |
Hearron, MS | 1 |
Tazoe, N | 1 |
Ikezaki, N | 1 |
Ito, J | 1 |
Kuwahara, K | 1 |
Hara, M | 1 |
Nakayama, M | 1 |
Sato, T | 1 |
Pickvance, NJ | 1 |
Sigidin, IaA | 1 |
Murav'ev, IuV | 1 |
Salisbury, R | 1 |
Alam-Siddiqi, M | 1 |
Taylor, L | 1 |
Grennan, DM | 1 |
Skosey, JL | 1 |
Finch, WR | 1 |
Lomen, PL | 2 |
Lamborn, KR | 2 |
Brinn, EL | 1 |
Pullar, T | 1 |
Zoma, AA | 1 |
Madhok, R | 1 |
3 reviews available for flurbiprofen and Rheumatoid Arthritis
Article | Year |
---|---|
Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Flurbiprofen; Humans; Risk Factors; | 2007 |
Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Interactions; Flurbipr | 1979 |
The propionic acids: a personal perspective.
Topics: Analgesia; Animals; Arthritis, Rheumatoid; Aspirin; Drug Therapy; Flurbiprofen; Humans; Ibuprofen; P | 1992 |
38 trials available for flurbiprofen and Rheumatoid Arthritis
Article | Year |
---|---|
A multicentre comparison of flurbiprofen and naproxen in rheumatoid arthritis: a four-week study in 118 patients.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Flurbiprofen; Humans; Male; Middle Aged; Na | 1983 |
Treatment of rheumatoid arthritis with flurbiprofen: a comparison with enteric-coated aspirin.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; | 1981 |
A double-blind comparison of flurbiprofen and indomethacin suppositories in the treatment of osteoarthrosis and rheumatoid disease.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; H | 1981 |
Interaction between flurbiprofen and indomethacin in rheumatoid arthritis.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Child; Child, Preschool; Clinical Trials as Topic; Double- | 1982 |
Flurbiprofen--a new anti-prostaglandin anti-inflammatory drug in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; H | 1981 |
[Flurbiprofen (Flugalin) - a new non-steroidal antirheumatic agent from the propionic acid derivative series].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Flurbiprofen; Humans; Male; Middle Aged; Os | 1982 |
Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeutic effectiveness of flurbiprofen at different times of day.
Topics: Arthritis, Rheumatoid; Circadian Rhythm; Drug Administration Schedule; Flurbiprofen; Humans; Pain; P | 1981 |
Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combinati | 1994 |
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri | 1976 |
Flurbiprofen-aspirin interaction: a double-blind crossover study.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Fl | 1977 |
A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Hu | 1977 |
Flurbiprofen at night.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; | 1977 |
A double-blind crossover study to compare the efficacy of three dosage levels of flurbiprofen in the treatment of rheumatoid disease and osteoarthrosis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doub | 1977 |
Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Flurbiprofen; Humans; Ibup | 1977 |
Steroid-sparing action of flurbiprofen: use of an additional parameter of joint scans with 99m technetium.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Dexamethasone; Double-Blind Meth | 1977 |
A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbipro | 1977 |
A comparative study of the long-term efficacy of flurbiprofen and indomethacin in the treatment of rheumatoid arthritis, with special reference to iron metabolism.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Humans; | 1977 |
Controlled clinical trial comparing flurbiprofen and phenylbutazone in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Flurbiprofen; Humans; Phenylbu | 1977 |
Flurbiprofen and indomethacin in the treatment of rheumatoid arthritis: a double-blind crossover study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Double-Blind Meth | 1977 |
Continued use of non-steroidal anti-inflammatory drugs: an index of clinical efficacy.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1978 |
A double-blind, crossover trial of mefenamic acid, sulindac and flurbiprofen in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbipro | 1979 |
Flurbiprofen and phenylbutazone in rheumatoid arthritis and osteoarthrosis: a double-blind study.
Topics: Adult; Arthritis, Rheumatoid; Double-Blind Method; Female; Flurbiprofen; Humans; Male; Osteoarthriti | 1979 |
[Effects of flurbiprofen in chronic rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Flurbiprofen; Humans; Male; Propio | 1976 |
Flurbiprofen in rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Rheumatoid; Female; Flurbiprofen; Humans; Indomethacin; Inflammation; Male; Prop | 1977 |
[Comparative evaluation of the therapeutic efficiency of flurbiprofene in rheumatoid polyarthritis].
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Biphenyl Compounds; Chemical Phenomena; Chemistry; Cl | 1975 |
The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bo | 1992 |
Clinical safety of flurbiprofen.
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Digestive System; Female; Flurbipro | 1990 |
A comparison of flurbiprofen and naproxen in the treatment of rheumatoid arthritis: a Canadian multi-centre study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Female; Flurbiprofen | 1990 |
Flurbiprofen.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Flurbiprofen; Gastrointestinal Diseases; Hum | 1989 |
[Use of flugalin and profenid in patients with rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1988 |
A comparative analysis of two dosing strategies of flurbiprofen in rheumatoid arthritis: an application of sequential trial design.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug | 1988 |
A long-term study of flurbiprofen in rheumatological disorders: I. Rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Constipation; Dizziness; | 1986 |
Flurbiprofen versus naproxen in the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug | 1986 |
Comparison of two dosing schedules of flurbiprofen for patients with rheumatoid arthritis. Twice-daily versus four-times-a-day schedules.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Administration Schedu | 1986 |
The optimum interval between flurbiprofen doses--scheduling for circadian rhythms in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Female; | 1987 |
[Experience with using a new antirheumatic drug flugalin].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Flurbiprofen; Follow-Up Studie | 1985 |
Flurbiprofen in the treatment of rheumatoid arthritis. A comparison with aspirin.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Drug Evaluation; Female; Flurbiprofen; Humans; Male; Mi | 1986 |
Have the newer NSAIDS contributed to the management of rheumatoid arthritis?
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Sedimentation; Feprazone; Flurbiprofen; Human | 1985 |
26 other studies available for flurbiprofen and Rheumatoid Arthritis
Article | Year |
---|---|
Development of novel pH-sensitive nanoparticle-based transdermal patch for management of rheumatoid arthritis.
Topics: Administration, Cutaneous; Arthritis, Rheumatoid; Drug Delivery Systems; Flurbiprofen; Humans; Hydro | 2020 |
Pemphigus erythematosus induced by thiopronine.
Topics: Aged; Amino Acids, Sulfur; Arthritis, Rheumatoid; Biopsy; Drug Therapy, Combination; Flurbiprofen; H | 1982 |
Biological rhythms and their effect in the assessment of disease activity in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Female; Flurbiprofen; Humans; Menstruation; Per | 1984 |
Steroid-sparing action of flurbiprofen and indomethacin in rheumatoid arthritis: a nine-week study.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Flurbiprofen; Hum | 1983 |
Antiprostaglandin synthetase activity of nonsteroidal anti-inflammatory drugs and gastrointestinal micro-bleeding: a comparison of flurbiprofen with benoxaprofen.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzoxazoles; Cyclooxygenase Inhibitors; Fece | 1981 |
Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Flurbiprofen; Humans; Leukocyte Count; Male; Middle Aged | 1981 |
Nonsteroidal antiinflammatory drug desensitization using flurbiprofen (Ansaid)
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cross Reactions; Des | 1993 |
Six-month prospective study to monitor the treatment of rheumatic diseases with sustained-release flurbiprofen.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Delayed-Act | 2000 |
A comparison of the effect of flurbiprofen on prostaglandin synthetase from human rheumatoid synovium and enzymatically active animal tissues.
Topics: Animals; Arthritis, Rheumatoid; Aspirin; Cattle; Cyclooxygenase Inhibitors; Flurbiprofen; Humans; In | 1976 |
A long-term assessment of flurbiprofen.
Topics: Arthritis; Arthritis, Rheumatoid; Bone Diseases; Female; Flurbiprofen; Humans; Joint Diseases; Male; | 1977 |
Prostaglandin synthetase activity from human rheumatoid synovial tissue and its inhibition by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Cattle; Depression, Chemical; Flu | 1975 |
Serum concentrations of flurbiprofen in rheumatoid patients receiving flurbiprofen over long periods of time.
Topics: Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 1977 |
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap | 1975 |
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu | 1975 |
Digital subtraction radiography for the assessment of bone changes in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone and Bones; Cadaver; Flurbiprofen; Hand; Humans; Male; Middl | 1992 |
The kinetics of flurbiprofen in synovial fluid.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Flurbiprofen; Humans; Middle Aged; Software; Synovia | 1991 |
The pharmacokinetics of the enantiomers of flurbiprofen in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Flurbiprofen; Half-Life; Humans; Middle Aged; Stereoisomerism; Synovial | 1991 |
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Flurbiprofen; Humans; | 1990 |
A multiple dose pharmacokinetic and tolerance study of once daily 200 mg sustained-release flurbiprofen capsules in young and very elderly patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Capsules; Delayed-Action Preparations; | 1990 |
[Non-steroid anti-inflammatory drugs and beta-endorphin].
Topics: Arthritis, Rheumatoid; beta-Endorphin; Endorphins; Female; Flurbiprofen; Humans; Male; Osteoarthriti | 1985 |
Variability in response to nonsteroidal anti-inflammatory analgesics: evidence from controlled clinical therapeutic trial of flurbiprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Flurbiprofen; H | 1988 |
A case of acute interstitial nephritis induced by flurbiprofen.
Topics: Acute Disease; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheum | 1987 |
Plasma and synovial fluid kinetics of flurbiprofen in rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Flurbiprofen; | 1986 |
Flurbiprofen in rheumatoid arthritis: duration of analgesic effect.
Topics: Arthritis, Rheumatoid; Flurbiprofen; Humans; Propionates | 1986 |
Review of the dosing regimens for flurbiprofen. A potent analgesic/anti-inflammatory agent.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Flurbiprofen; Humans; Pain; Propionates | 1986 |
Safety of flurbiprofen in the treatment of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. A summary of liver and kidney assay data.
Topics: Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspi | 1986 |