flurbiprofen has been researched along with Reperfusion Injury in 6 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure." | 8.12 | Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9. ( Nie, Y; Wang, L; Xiong, W; Yang, B, 2022) |
| "Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury." | 5.48 | Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018) |
| "Flurbiprofen acts as a nonselective inhibitor for cyclooxygenases (COX-1 and COX-2), but its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear." | 5.38 | Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3β signaling and mitochondrial permeability transition. ( Chen, H; Fu, H; Guo, M; Liu, F; Shi, X; Wang, C; Wang, Q; Xu, H, 2012) |
| "Flurbiprofen has been shown to reduce cerebral ischemia/reperfusion injury in both focal and global cerebral ischemia models, but the mechanism remains unclear." | 5.37 | The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. ( Chen, L; Liu, X; Sun, B; Wei, X; Xiang, Y; Zhang, X, 2011) |
| "The modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure." | 4.12 | Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9. ( Nie, Y; Wang, L; Xiong, W; Yang, B, 2022) |
| "Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury." | 1.48 | Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018) |
| "Flurbiprofen acts as a nonselective inhibitor for cyclooxygenases (COX-1 and COX-2), but its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear." | 1.38 | Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3β signaling and mitochondrial permeability transition. ( Chen, H; Fu, H; Guo, M; Liu, F; Shi, X; Wang, C; Wang, Q; Xu, H, 2012) |
| "Flurbiprofen has been shown to reduce cerebral ischemia/reperfusion injury in both focal and global cerebral ischemia models, but the mechanism remains unclear." | 1.37 | The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. ( Chen, L; Liu, X; Sun, B; Wei, X; Xiang, Y; Zhang, X, 2011) |
| "The flurbiprofen treatment, 30 min prior to ischemia and 4 h post-reperfusion, afforded significant neuroprotection from ischemic injury as evidenced by reduction in cerebral infarct volume and neurobehavioral deficit." | 1.36 | Neuroprotective effect of flurbiprofen in focal cerebral ischemia: the possible role of ASIC1a. ( Mishra, V; Raghubir, R; Verma, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, B | 1 |
| Nie, Y | 1 |
| Wang, L | 1 |
| Xiong, W | 1 |
| Wu, H | 1 |
| Tang, C | 1 |
| Tai, LW | 1 |
| Yao, W | 1 |
| Guo, P | 1 |
| Hong, J | 1 |
| Yang, X | 1 |
| Li, X | 1 |
| Jin, Z | 1 |
| Ke, J | 1 |
| Wang, Y | 1 |
| Mishra, V | 1 |
| Verma, R | 1 |
| Raghubir, R | 1 |
| Sun, B | 1 |
| Chen, L | 1 |
| Wei, X | 1 |
| Xiang, Y | 1 |
| Liu, X | 1 |
| Zhang, X | 1 |
| Fu, H | 1 |
| Chen, H | 1 |
| Wang, C | 1 |
| Xu, H | 1 |
| Liu, F | 1 |
| Guo, M | 1 |
| Wang, Q | 1 |
| Shi, X | 1 |
| Ljungman, AG | 1 |
| Grum, CM | 1 |
| Deeb, GM | 1 |
| Bolling, SF | 1 |
| Morganroth, ML | 1 |
6 other studies available for flurbiprofen and Reperfusion Injury
| Article | Year |
|---|---|
Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9.
Topics: Animals; Brain; Brain Ischemia; Cytokines; Disease Models, Animal; Flurbiprofen; Male; Malondialdehy | 2022 |
Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Flurbiprof | 2018 |
Neuroprotective effect of flurbiprofen in focal cerebral ischemia: the possible role of ASIC1a.
Topics: Acid Sensing Ion Channels; Animals; Brain; Brain Infarction; Calcium; Flurbiprofen; Ischemic Attack, | 2010 |
The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain Ischemia; Cytoprotection; Flurbip | 2011 |
Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3β signaling and mitochondrial permeability transition.
Topics: Animals; Calcium; Caspase 3; Caspase 9; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitor | 2012 |
Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Cyclooxygenase Inhibitors; Dinop | 1991 |