Page last updated: 2024-10-27

flurbiprofen and Pregnancy

flurbiprofen has been researched along with Pregnancy in 16 studies

Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"In this prospective double-blind randomized study, we evaluated the analgesic effect and potential effect on pregnancy rate of the nonsteroidal anti-inflammatory drug flurbiprofen axetil in patients undergoing ultrasound-guided transvaginal oocyte retrieval under propofol-remifentanil anesthesia."9.24Flurbiprofen Axetil Provides Effective Analgesia Without Changing the Pregnancy Rate in Ultrasound-Guided Transvaginal Oocyte Retrieval: A Double-Blind Randomized Controlled Trial. ( Feng, Y; Jiang, Y; Lu, Q; Zhao, H, 2017)
"In this prospective double-blind randomized study, we evaluated the analgesic effect and potential effect on pregnancy rate of the nonsteroidal anti-inflammatory drug flurbiprofen axetil in patients undergoing ultrasound-guided transvaginal oocyte retrieval under propofol-remifentanil anesthesia."5.24Flurbiprofen Axetil Provides Effective Analgesia Without Changing the Pregnancy Rate in Ultrasound-Guided Transvaginal Oocyte Retrieval: A Double-Blind Randomized Controlled Trial. ( Feng, Y; Jiang, Y; Lu, Q; Zhao, H, 2017)
"To observe the effect of propofol combined with flurbiprofen axetil for abortion anesthesia."2.72[Clinical observation of propofol combined with flurbiprofen axetil for induced abortion anesthesia]. ( Guo, QL; Xie, YQ; Yang, HW, 2006)
" This study aimed to compare the analgesic effects of tramadol alone and combined with butorphanol or flurbiprofen axetil after a cesarean section."1.72Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis. ( Bao, X; Deng, Q; Li, H; Liang, Y; Liu, W; Peng, J; Tan, D; Wu, Z; Yan, G; Yang, G, 2022)
" In cows, stereoselectivity was observed in Cl(B) and elimination half-life (t(1)/2) only in the early lactation group."1.33Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines. ( Auza, N; Igarza, L; Soraci, A; Zeballos, H, 2006)
" Paired milk and plasma samples were obtained during this period of dosing as well as after the last dose."1.28Flurbiprofen in post-partum women: plasma and breast milk disposition. ( Brown, RD; Cook, SM; Hinson, JL; Johnson, VA; Smith, IJ; Whitt, RT; Wilson, JT, 1989)
" Dose-response curves were studied at 4 h following administration of indomethacin on the 19th, 20th, and 21st days, and flurbiprofen on the 20th and 21st days."1.27In vivo constriction of the ductus arteriosus by nonsteroidal antiinflammatory drugs in near-term and preterm fetal rats. ( Momma, K; Takao, A, 1987)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19908 (50.00)18.7374
1990's1 (6.25)18.2507
2000's2 (12.50)29.6817
2010's3 (18.75)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Yang, G3
Wu, Z2
Deng, Q2
Liang, Y2
Bao, X2
Yan, G2
Peng, J3
Liu, W2
Tan, D2
Li, H3
Duan, G1
Duan, Z1
Li, J1
Tang, X1
Fu, SC1
Wang, CY1
Lin, CK1
Zhao, H1
Feng, Y1
Jiang, Y1
Lu, Q1
Kimura, M1
Okamoto, T1
Tsukagoshi, H1
Sato, J1
Saito, S1
Igarza, L1
Soraci, A1
Auza, N1
Zeballos, H1
Yang, HW1
Xie, YQ1
Guo, QL1
Sheehan, TJ1
Broughton Pipkin, F1
O'Brien, PM1
Brown, CG1
Poyser, NL1
Burvenich, C1
Peeters, G1
Funakoshi, K1
Nozu, K1
Honma, H1
al-Zadjali, KH1
Boyle, FC1
Ohia, SE1
MacLennan, SJ1
McGrath, JC1
Whittle, MJ1
Smith, IJ1
Hinson, JL1
Johnson, VA1
Brown, RD1
Cook, SM1
Whitt, RT1
Wilson, JT1
Bloomfield, SS1
Mitchell, J1
Cissell, G1
Barden, TP1
Momma, K1
Takao, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Postoperative Pain Between Patients Received Primary and Repeated Caesarean Section[NCT03009955]168 participants (Actual)Observational2016-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for flurbiprofen and Pregnancy

ArticleYear
Flurbiprofen Axetil Provides Effective Analgesia Without Changing the Pregnancy Rate in Ultrasound-Guided Transvaginal Oocyte Retrieval: A Double-Blind Randomized Controlled Trial.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:4

    Topics: Adult; Analgesia; Anesthesia, General; Double-Blind Method; Embryo Implantation; Female; Flurbiprofe

2017
Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia.
    Journal of anesthesia, 2011, Volume: 25, Issue:5

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Ant

2011
[Clinical observation of propofol combined with flurbiprofen axetil for induced abortion anesthesia].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006, Volume: 31, Issue:5

    Topics: Abortion, Induced; Adult; Anesthetics, Intravenous; Drug Synergism; Female; Flurbiprofen; Humans; Pr

2006
Flurbiprofen, aspirin, codeine, and placebo for postpartum uterine pain.
    The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A

    Topics: Adult; Aspirin; Clinical Trials as Topic; Codeine; Double-Blind Method; Female; Flurbiprofen; Humans

1986

Other Studies

12 other studies available for flurbiprofen and Pregnancy

ArticleYear
Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis.
    BMC anesthesiology, 2022, 12-16, Volume: 22, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Cesarean Secti

2022
Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis.
    BMC anesthesiology, 2022, 12-16, Volume: 22, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Cesarean Secti

2022
Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis.
    BMC anesthesiology, 2022, 12-16, Volume: 22, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Cesarean Secti

2022
Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis.
    BMC anesthesiology, 2022, 12-16, Volume: 22, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Cesarean Secti

2022
Comparison of postoperative pain between patients who underwent primary and repeated cesarean section: a prospective cohort study.
    BMC anesthesiology, 2019, 10-22, Volume: 19, Issue:1

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cesarean Section; Cesarean Sec

2019
Do postpartum nonsteroidal antiinflammatory drugs (NSAIDs) affect neonatal hyperbilirubinaemia?
    Taiwanese journal of obstetrics & gynecology, 2020, Volume: 59, Issue:6

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Female; Flurbiprofen;

2020
Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines.
    Veterinary research communications, 2006, Volume: 30, Issue:5

    Topics: Age Factors; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; C

2006
Prostaglandins, angiotensin and blood pressure in pregnant rabbits.
    Clinical and experimental hypertension. Part B, Hypertension in pregnancy, 1983, Volume: 2, Issue:2

    Topics: Alprostadil; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Flur

1983
Studies on the control of prostaglandin production by the hypothalamus in relation to LH release in the rat.
    The Journal of endocrinology, 1984, Volume: 103, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Castration; Circadian Rhythm; Dinoprost; Dinoprostone; Estrad

1984
Effect of prostaglandin synthetase inhibitors on mammary blood flow during experimentally induced mastitis in lactating goats.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 258, Issue:1

    Topics: Animals; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Goats; Indomethacin; Lactation; Lipopolysa

1982
[Effects of flurbiprofen and indomethacin on release of prostaglandin F 2 alpha from uterus and plasma levels of sex hormones during parturition in rats (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1979, Volume: 99, Issue:1

    Topics: Animals; Corpus Luteum; Female; Flurbiprofen; Gonadal Steroid Hormones; In Vitro Techniques; Indomet

1979
Inhibition of prostaglandin synthetase alters uterine response to adrenoceptor agonists in pregnant and post-partum rats.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: Acetylcholine; Albuterol; Animals; Cyclooxygenase Inhibitors; Endometrium; Epinephrine; Female; Flur

1991
Inhibition of the oxygen-induced contraction of the isolated human umbilical artery by indomethacin, flurbiprofen, aspirin and drugs modifying Ca2+ disposition.
    Prostaglandins, 1988, Volume: 36, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1988
Flurbiprofen in post-partum women: plasma and breast milk disposition.
    Journal of clinical pharmacology, 1989, Volume: 29, Issue:2

    Topics: Adult; Breast; Chromatography, High Pressure Liquid; Female; Flurbiprofen; Humans; Lactation; Milk,

1989
In vivo constriction of the ductus arteriosus by nonsteroidal antiinflammatory drugs in near-term and preterm fetal rats.
    Pediatric research, 1987, Volume: 22, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Ductus Arteriosu

1987