flurbiprofen has been researched along with Multiple Sclerosis in 4 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Consequently, the development of an easy-to-swallow liquid oral dosage form supported by a combined PBPK-IVIVC model was approached." | 1.51 | Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001. ( Ashtikar, M; Geisslinger, G; Jung, F; Nothnagel, L; Parnham, MJ; Rossmanith, T; Thurn, M; Wacker, MG, 2019) |
| "R-flurbiprofen treatment increased CD4(+)CD25(+)FoxP3(+) regulatory T cells, CTLA4(+) inhibitory T cells and interleukin-10, whereas the EAE-evoked upregulation of pro-inflammatory genes in the spinal cord was strongly reduced." | 1.40 | R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. ( Altmann, C; Bishay, P; de Bruin, N; Ferreirós, N; Geisslinger, G; Häussler, A; Lötsch, J; Männich, J; Parnham, MJ; Schmitz, K; Tegeder, I; Ultsch, A, 2014) |
| "Flurbiprofen axetil was used for slight postoperative fever." | 1.35 | [Perioperative anesthetic management of a patient with multiple sclerosis]. ( Hirose, M; Ishimoto, M; Matsuki, Y; Nobukawa, Y; Okada, A; Shigemi, K; Shimizu, K; Tabata, M; Tsugita, K; Ueda, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, F | 2 |
| Thurn, M | 2 |
| Krollik, K | 1 |
| Li, D | 1 |
| Dressman, J | 1 |
| Alig, E | 1 |
| Fink, L | 1 |
| Schmidt, MU | 1 |
| Wacker, MG | 2 |
| Nothnagel, L | 1 |
| Rossmanith, T | 1 |
| Ashtikar, M | 1 |
| Geisslinger, G | 2 |
| Parnham, MJ | 2 |
| Schmitz, K | 1 |
| de Bruin, N | 1 |
| Bishay, P | 1 |
| Männich, J | 1 |
| Häussler, A | 1 |
| Altmann, C | 1 |
| Ferreirós, N | 1 |
| Lötsch, J | 1 |
| Ultsch, A | 1 |
| Tegeder, I | 1 |
| Okada, A | 1 |
| Hirose, M | 1 |
| Shimizu, K | 1 |
| Tsugita, K | 1 |
| Matsuki, Y | 1 |
| Nobukawa, Y | 1 |
| Tabata, M | 1 |
| Ishimoto, M | 1 |
| Ueda, M | 1 |
| Shigemi, K | 1 |
4 other studies available for flurbiprofen and Multiple Sclerosis
| Article | Year |
|---|---|
Sustained-release hot melt extrudates of the weak acid TMP-001: A case study using PBB modelling.
Topics: Administration, Oral; Arginine; Biological Availability; Delayed-Action Preparations; Drug Compoundi | 2021 |
Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.
Topics: Administration, Oral; Anti-Inflammatory Agents; Computer Simulation; Deglutition; Deglutition Disord | 2019 |
R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Encephalomyelitis, | 2014 |
[Perioperative anesthetic management of a patient with multiple sclerosis].
Topics: Adult; Anesthesia, Epidural; Fentanyl; Fever; Flurbiprofen; Humans; Infusions, Intravenous; Laparosc | 2009 |