flurbiprofen has been researched along with Inflammation in 62 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nimesulide have been studied in a double blind study compared with flurbiprofen, in 98 patients aged between 18 and 75 suffering from pain-inflammatory pathologies of ENT nature." | 9.07 | [Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat]. ( Lomeo, G; Monea, P; Rossi, M; Scaricabarozzi, I; Trezzani, R; Tringali, G, 1991) |
| "A consecutive, random, prospective study was conducted to compare the effect of topical dexamethasone and flurbiprofen drops on postoperative inflammation in patients undergoing extracapsular cataract extraction with lens implantation." | 9.06 | Management of postoperative inflammation: dexamethasone versus flurbiprofen, a quantitative study using the new Flare Cell Meter. ( Drews, RC, 1990) |
| "Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis." | 9.04 | Flurbiprofen in rheumatoid arthritis therapy. ( Loizzi, P; Numo, R; Pipitone, V, 1977) |
| " Previous studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to intervene the arachidonic acid (AA) metabolite network and control inflammation." | 7.83 | Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution. ( Dai, Z; He, S; Lai, L; Li, K; Liu, Y; McClendon, CL; Meng, H; Shang, E; Zhang, X, 2016) |
| "Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties." | 6.67 | [The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. ( Scaricabarozzi, I; Scolari, G; Vargiu, G, 1990) |
| "Pain is one of the cardinal signs accompanying inflammation." | 5.62 | Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. ( Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A, 2021) |
| "Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury." | 5.48 | Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018) |
| "Flurbiprofen is a powerful nonsteroidal anti-inflammatory drug (NSAID)." | 5.33 | Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury. ( Bhatia, M; Huang, J; Moochhala, SM; Moore, PK, 2005) |
| "Flurbiprofen was less effective than indomethacin in the immediate hypersensitivity reaction (IHR) model." | 5.27 | In vivo effects of indomethacin and flurbiprofen on the locomotion of neutrophils elicited by immune and non-immune inflammation in the rat. ( Giroud, JP; Hakim, J; Perianin, A; Roch-Arveiller, M, 1984) |
| " Nimesulide have been studied in a double blind study compared with flurbiprofen, in 98 patients aged between 18 and 75 suffering from pain-inflammatory pathologies of ENT nature." | 5.07 | [Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat]. ( Lomeo, G; Monea, P; Rossi, M; Scaricabarozzi, I; Trezzani, R; Tringali, G, 1991) |
| "A consecutive, random, prospective study was conducted to compare the effect of topical dexamethasone and flurbiprofen drops on postoperative inflammation in patients undergoing extracapsular cataract extraction with lens implantation." | 5.06 | Management of postoperative inflammation: dexamethasone versus flurbiprofen, a quantitative study using the new Flare Cell Meter. ( Drews, RC, 1990) |
| "Seventy glaucomatous eyes received argon laser trabeculoplasty (ALT) to 180 degrees of the trabecular meshwork." | 5.05 | Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty. A trial with flurbiprofen and indomethacin. ( Hotchkiss, ML; Pollack, IP; Quigley, HA; Robin, AL, 1984) |
| "Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis." | 5.04 | Flurbiprofen in rheumatoid arthritis therapy. ( Loizzi, P; Numo, R; Pipitone, V, 1977) |
| "Potential benefits of combining docosahexaenoic acid (DHA), an omega-3 fatty acid with flurbiprofen (Flu), a non-steroidal anti-inflammatory drug in ameliorating obesity remain to be elucidated." | 3.91 | Docosahexaenoic acid-flurbiprofen combination ameliorates metaflammation in rats fed on high-carbohydrate high-fat diet. ( Al-Ashmawy, GM; El-Ashmawy, NE; Kamel, AA, 2019) |
| " Previous studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to intervene the arachidonic acid (AA) metabolite network and control inflammation." | 3.83 | Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution. ( Dai, Z; He, S; Lai, L; Li, K; Liu, Y; McClendon, CL; Meng, H; Shang, E; Zhang, X, 2016) |
| "Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury." | 3.76 | Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. ( Caniglia, S; Impagnatiello, F; L'Episcopo, F; Marchetti, B; Morale, MC; Serra, PA; Testa, N; Tirolo, C, 2010) |
| "Effects of topical flurbiprofen, a highly potent prostaglandin synthetase inhibitor, were evaluated during planned extracapsular cataract extraction in diabetic and nondiabetic patients." | 3.68 | Topical flurbiprofen in intraocular surgery on diabetic and nondiabetic patients. ( Takase, M; Tsuchisaka, H, 1990) |
| "The anti-inflammatory effects of flurbiprofen and a number of other antirheumatic agents were studied in the rat using a model of inflammation, which involved the subcutaneous implantation of polyurethane cubes impregnated with an irritant." | 3.65 | The effect of anti-inflammatory and antirheumatic drugs on inflammation in the rat. ( Currey, HL; Vernon-Roberts, B; Woodland, J, 1977) |
| "05), 24 h dosage of analgesia were significantly less (P < 0." | 2.80 | Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial. ( Chen, JQ; Hu, YM; Miao, JZ; Wen, LY; Wu, Z; Xue, R, 2015) |
| " No significant differences between treatment groups were found in neuropsychological tests but a positive dose-response trend was found on executive function in APOE4 carriers." | 2.78 | CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study. ( Bottini, G; Calza, L; Casula, D; Cicirello, H; Fernandez, M; Fiorentini, F; Franceschi, M; Frigerio, E; Giardino, L; Imbimbo, BP; Norris, D; Nunez, M; Ross, J; Scarpini, E; Sharma, S; Sivilia, S; Winston, J, 2013) |
| "Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties." | 2.67 | [The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. ( Scaricabarozzi, I; Scolari, G; Vargiu, G, 1990) |
| " Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays its onset." | 2.43 | Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. ( Praticò, D; Townsend, KP, 2005) |
| "Pain is one of the cardinal signs accompanying inflammation." | 1.62 | Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. ( Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A, 2021) |
| "Flurbiprofen (FP) is one of the most potent nonsteroidal anti-inflammatory drugs with very low bioavailability of approximately 12% following transdermal administration, compared to that after oral administration." | 1.56 | Development of galangal essential oil-based microemulsion gel for transdermal delivery of flurbiprofen: simultaneous permeability evaluation of flurbiprofen and 1,8-cineole. ( Chen, J; Dong, J; Dong, YF; Feng, H; Gu, W; Wu, FY; Yang, BQ; Zhu, XM, 2020) |
| "Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury." | 1.48 | Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018) |
| " It is concluded that the synthesized prodrugs have promising pharmacological activities with reduced GI adverse effects than the parent drug." | 1.43 | Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling. ( Abdullah, S; Ahsan, H; Ashraf, Z; Hassan, M; Kanwal, M; Kim, SJ; Waheed, M, 2016) |
| " PGE(2) levels in mice dosed with R-2-phenylpropionic acid were elevated." | 1.36 | Role of COX-2 in nonsteroidal anti-inflammatory drug enteropathy in rodents. ( Bjarnason, IT; Hotz-Behofsits, C; Simpson, RJ; Walley, M, 2010) |
| "Flurbiprofen is a powerful nonsteroidal anti-inflammatory drug (NSAID)." | 1.33 | Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury. ( Bhatia, M; Huang, J; Moochhala, SM; Moore, PK, 2005) |
| "Sham treatment, flurbiprofen, and the low-dose HCT 1026 did not affect pathology; however, a higher dose of HCT 1026 reduced both A load and amount of microglial activation surrounding plaques." | 1.33 | Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology. ( Kadish, I; van Groen, T, 2005) |
| " We infused the proinflammagen lipopolysaccharide into the basal forebrain of young rats and determined whether the chronic administration of two novel non-steroidal anti-inflammatory drugs or a pan-caspase synthesis inhibitor, z-Val-Ala-Asp(OMe)-fluoromethyl ketone (zVAD), could provide neuroprotection from the cytotoxic effects of the neuroinflammation." | 1.31 | Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. ( Del Soldato, P; Fiorucci, S; Hauss-Wegrzyniak, B; McGann, K; Mencarelli, A; Wenk, GL, 2000) |
| "Flurbiprofen was less effective than indomethacin in the immediate hypersensitivity reaction (IHR) model." | 1.27 | In vivo effects of indomethacin and flurbiprofen on the locomotion of neutrophils elicited by immune and non-immune inflammation in the rat. ( Giroud, JP; Hakim, J; Perianin, A; Roch-Arveiller, M, 1984) |
| " Nafazatrom (Bayer 6575), quercetin and NDGA, which inhibit LPO activity in vitro, were inactive against all parameters when dosed at 100 mg per kg p." | 1.27 | Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1. ( Aked, D; Foster, SJ; Howarth, A; McCormick, ME, 1986) |
| " The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid." | 1.25 | Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (33.87) | 18.7374 |
| 1990's | 9 (14.52) | 18.2507 |
| 2000's | 13 (20.97) | 29.6817 |
| 2010's | 17 (27.42) | 24.3611 |
| 2020's | 2 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Voilley, N | 1 |
| de Weille, J | 1 |
| Mamet, J | 1 |
| Lazdunski, M | 1 |
| Amir, M | 1 |
| Kumar, H | 1 |
| Javed, SA | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Meng, H | 1 |
| McClendon, CL | 1 |
| Dai, Z | 1 |
| Li, K | 1 |
| Zhang, X | 1 |
| He, S | 1 |
| Shang, E | 1 |
| Liu, Y | 1 |
| Lai, L | 1 |
| Dong, J | 1 |
| Zhu, XM | 1 |
| Wu, FY | 1 |
| Yang, BQ | 1 |
| Feng, H | 1 |
| Dong, YF | 1 |
| Gu, W | 1 |
| Chen, J | 1 |
| Buisseret, B | 1 |
| Guillemot-Legris, O | 1 |
| Ben Kouidar, Y | 1 |
| Paquot, A | 1 |
| Muccioli, GG | 1 |
| Alhouayek, M | 1 |
| Huang, S | 1 |
| Cao, X | 1 |
| Li, J | 1 |
| Han, Y | 1 |
| Wu, H | 1 |
| Tang, C | 1 |
| Tai, LW | 1 |
| Yao, W | 1 |
| Guo, P | 1 |
| Hong, J | 1 |
| Yang, X | 1 |
| Li, X | 1 |
| Jin, Z | 1 |
| Ke, J | 1 |
| Wang, Y | 1 |
| El-Ashmawy, NE | 1 |
| Al-Ashmawy, GM | 1 |
| Kamel, AA | 1 |
| Tiozzo Fasiolo, L | 1 |
| Manniello, MD | 1 |
| Bortolotti, F | 1 |
| Buttini, F | 1 |
| Rossi, A | 1 |
| Sonvico, F | 1 |
| Colombo, P | 1 |
| Valsami, G | 1 |
| Colombo, G | 1 |
| Russo, P | 1 |
| Vega, E | 1 |
| Egea, MA | 1 |
| Garduño-Ramírez, ML | 1 |
| García, ML | 1 |
| Sánchez, E | 1 |
| Espina, M | 1 |
| Calpena, AC | 1 |
| Calzà, L | 2 |
| Baldassarro, VA | 1 |
| Giuliani, A | 1 |
| Lorenzini, L | 1 |
| Fernandez, M | 2 |
| Mangano, C | 1 |
| Sivilia, S | 2 |
| Alessandri, M | 1 |
| Gusciglio, M | 1 |
| Torricella, R | 1 |
| Giardino, L | 2 |
| Ross, J | 1 |
| Sharma, S | 1 |
| Winston, J | 1 |
| Nunez, M | 1 |
| Bottini, G | 1 |
| Franceschi, M | 1 |
| Scarpini, E | 1 |
| Frigerio, E | 1 |
| Fiorentini, F | 1 |
| Norris, D | 1 |
| Cicirello, H | 1 |
| Casula, D | 1 |
| Imbimbo, BP | 1 |
| Chen, JQ | 1 |
| Wu, Z | 1 |
| Wen, LY | 1 |
| Miao, JZ | 1 |
| Hu, YM | 1 |
| Xue, R | 1 |
| Malipeddi, VR | 1 |
| Dua, K | 1 |
| Awasthi, R | 1 |
| Ashraf, Z | 1 |
| Kanwal, M | 1 |
| Hassan, M | 1 |
| Abdullah, S | 1 |
| Waheed, M | 1 |
| Ahsan, H | 1 |
| Kim, SJ | 1 |
| Verma, P | 1 |
| Prajapati, SK | 1 |
| Yadav, R | 1 |
| Senyschyn, D | 1 |
| Shea, PR | 1 |
| Trevaskis, NL | 1 |
| Hotz-Behofsits, C | 1 |
| Simpson, RJ | 1 |
| Walley, M | 1 |
| Bjarnason, IT | 1 |
| L'Episcopo, F | 2 |
| Tirolo, C | 2 |
| Caniglia, S | 2 |
| Testa, N | 2 |
| Serra, PA | 1 |
| Impagnatiello, F | 2 |
| Morale, MC | 2 |
| Marchetti, B | 2 |
| Esme, H | 1 |
| Kesli, R | 1 |
| Apiliogullari, B | 1 |
| Duran, FM | 1 |
| Yoldas, B | 1 |
| Fratelli, M | 1 |
| Minto, M | 1 |
| Crespi, A | 1 |
| Erba, E | 1 |
| Vandenabeele, P | 1 |
| Del Soldato, P | 2 |
| Ghezzi, P | 1 |
| Breen, KM | 1 |
| Billings, HJ | 1 |
| Debus, N | 1 |
| Karsch, FJ | 1 |
| Schlegel, T | 1 |
| Sauer, SK | 1 |
| Handwerker, HO | 1 |
| Reeh, PW | 1 |
| van Groen, T | 1 |
| Kadish, I | 1 |
| Gasparini, L | 1 |
| Ongini, E | 1 |
| Wilcock, D | 1 |
| Morgan, D | 1 |
| Huang, J | 1 |
| Moochhala, SM | 1 |
| Moore, PK | 1 |
| Bhatia, M | 1 |
| Townsend, KP | 1 |
| Praticò, D | 1 |
| Arbez, N | 1 |
| Gautheron, V | 1 |
| Brugg, B | 1 |
| Mariani, J | 1 |
| Rovira, C | 1 |
| Hurvitz, LM | 1 |
| Spaeth, GL | 1 |
| Zakhour, I | 1 |
| Mahmood, E | 1 |
| Murray, G | 1 |
| Hotchkiss, ML | 1 |
| Robin, AL | 2 |
| Pollack, IP | 1 |
| Quigley, HA | 1 |
| Perianin, A | 3 |
| Roch-Arveiller, M | 2 |
| Giroud, JP | 3 |
| Hakim, J | 3 |
| Weinreb, RN | 1 |
| Baerveldt, G | 1 |
| Drake, MV | 1 |
| Blumenthal, M | 1 |
| Wilensky, J | 1 |
| Goddard, DH | 1 |
| Revell, PA | 1 |
| Cason, J | 1 |
| Gallagher, S | 1 |
| Currey, HL | 3 |
| Bhattacherjee, P | 1 |
| Williams, RN | 1 |
| Eakins, KE | 1 |
| Hillman, JS | 1 |
| Frank, GJ | 1 |
| Kheskani, MB | 1 |
| Berti, L | 1 |
| Gerli, P | 1 |
| Burdo, N | 1 |
| Black, AK | 1 |
| Greaves, MW | 1 |
| Hensby, CN | 1 |
| Howell, TH | 1 |
| Williams, RC | 1 |
| Struck, HG | 1 |
| Giessler, S | 1 |
| Giessler, C | 1 |
| Andrioli, G | 1 |
| Lussignoli, S | 1 |
| Gaino, S | 1 |
| Benoni, G | 1 |
| Bellavite, P | 1 |
| Wenk, GL | 1 |
| McGann, K | 1 |
| Mencarelli, A | 1 |
| Hauss-Wegrzyniak, B | 1 |
| Fiorucci, S | 1 |
| Tegeder, I | 2 |
| Niederberger, E | 2 |
| Israr, E | 2 |
| Gühring, H | 2 |
| Brune, K | 2 |
| Euchenhofer, C | 2 |
| Grösch, S | 2 |
| Geisslinger, G | 2 |
| Woodland, J | 2 |
| Vernon-Roberts, B | 2 |
| Swettenham, KV | 1 |
| Ford-Hutchinson, AW | 1 |
| Walker, JR | 1 |
| Connor, NS | 1 |
| Oliver, AM | 1 |
| Smith, MJ | 1 |
| Pipitone, V | 1 |
| Numo, R | 1 |
| Loizzi, P | 1 |
| Adams, SS | 1 |
| McCullough, KF | 1 |
| Nicholson, JS | 1 |
| Cooper, AL | 1 |
| Rothwell, NJ | 1 |
| Rossi, M | 1 |
| Monea, P | 1 |
| Lomeo, G | 1 |
| Tringali, G | 1 |
| Scaricabarozzi, I | 2 |
| Trezzani, R | 1 |
| Scolari, G | 1 |
| Vargiu, G | 1 |
| Tsuchisaka, H | 1 |
| Takase, M | 1 |
| Drews, RC | 1 |
| Troullos, ES | 1 |
| Hargreaves, KM | 1 |
| Butler, DP | 1 |
| Dionne, RA | 1 |
| Kantor, TG | 1 |
| Foster, SJ | 2 |
| McCormick, ME | 2 |
| Howarth, A | 2 |
| Aked, D | 1 |
| Rubin, RM | 1 |
| Rosenbaum, JT | 1 |
| Kuipers, H | 1 |
| Keizer, HA | 1 |
| Verstappen, FT | 1 |
| Costill, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Evaluation of Postoperative Edema and Pain Following Third Molar Extraction With Application of Pulsed Electromagnetic Field (PEMF) Therapy[NCT02376946] | 49 participants (Actual) | Interventional | 2014-01-31 | Terminated (stopped due to Sponsor decision) | |||
| Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for flurbiprofen and Inflammation
| Article | Year |
|---|---|
From the multifactorial nature of Alzheimer`s disease to multitarget therapy: the contribution of the translational approach.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Cyclopro | 2013 |
Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Flurbip | 2005 |
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammator | 2005 |
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; | 1993 |
14 trials available for flurbiprofen and Inflammation
| Article | Year |
|---|---|
Analgesic effect of flurbiprofen axetil in treatment of single hole thoracoscopic surgery for pneumothorax.
Topics: Anti-Inflammatory Agents, Non-Steroidal; China; Female; Flurbiprofen; Glucagon; Humans; Hydrocortiso | 2017 |
CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.
Topics: Adult; Aged; Amyloid Precursor Protein Secretases; Biomarkers; Cognitive Dysfunction; Cohort Studies | 2013 |
Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial.
Topics: Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combi | 2015 |
Effects of flurbiprofen on CRP, TNF-α, IL-6, and postoperative pain of thoracotomy.
Topics: Analgesics; C-Reactive Protein; Female; Flurbiprofen; Forced Expiratory Volume; Humans; Inflammation | 2011 |
A comparison of the effect of flurbiprofen, dexamethasone, and placebo on cyclocryotherapy-induced inflammation.
Topics: Adult; Aged; Anterior Chamber; Clinical Trials as Topic; Dexamethasone; Double-Blind Method; Female; | 1984 |
Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty. A trial with flurbiprofen and indomethacin.
Topics: Adult; Aged; Argon; Clinical Trials as Topic; Double-Blind Method; Eye Diseases; Female; Flurbiprofe | 1984 |
Flurbiprofen pretreatment in argon laser trabeculoplasty for primary open-angle glaucoma.
Topics: Aged; Double-Blind Method; Female; Flurbiprofen; Glaucoma, Open-Angle; Humans; Inflammation; Intraoc | 1984 |
Flurbiprofen and human intraocular inflammation.
Topics: Aqueous Humor; Cataract Extraction; Clinical Trials as Topic; Conjunctivitis; Corneal Diseases; Doub | 1980 |
Flurbiprofen in rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Rheumatoid; Female; Flurbiprofen; Humans; Indomethacin; Inflammation; Male; Prop | 1977 |
[Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Flurbiprofen; Hum | 1991 |
[The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Flurbiprofen; H | 1990 |
Management of postoperative inflammation: dexamethasone versus flurbiprofen, a quantitative study using the new Flare Cell Meter.
Topics: Administration, Topical; Aqueous Humor; Cataract Extraction; Cell Count; Dexamethasone; Flurbiprofen | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Influence of a prostaglandin-inhibiting drug on muscle soreness after eccentric work.
Topics: Adult; Exercise Test; Flurbiprofen; Glycogen; Humans; Inflammation; Male; Muscle Contraction; Muscle | 1985 |
44 other studies available for flurbiprofen and Inflammation
| Article | Year |
|---|---|
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; | 2001 |
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibup | 2008 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution.
Topics: Allosteric Site; Arachidonate 15-Lipoxygenase; Arachidonic Acid; Cell-Free System; Cyclooxygenase In | 2016 |
Development of galangal essential oil-based microemulsion gel for transdermal delivery of flurbiprofen: simultaneous permeability evaluation of flurbiprofen and 1,8-cineole.
Topics: Administration, Cutaneous; Alpinia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Cur | 2020 |
Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.
Topics: Animals; Biomarkers; Capsaicin; Carrageenan; Endocannabinoids; Flurbiprofen; Gene Expression Regulat | 2021 |
Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Flurbiprof | 2018 |
Docosahexaenoic acid-flurbiprofen combination ameliorates metaflammation in rats fed on high-carbohydrate high-fat diet.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Diet, | 2019 |
Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer's disease.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bra | 2019 |
Flurbiprofen PLGA-PEG nanospheres: role of hydroxy-β-cyclodextrin on ex vivo human skin permeation and in vivo topical anti-inflammatory efficacy.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adult; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrin | 2013 |
Development and characterization of solid dispersion-microsphere controlled release system for poorly water-soluble drug.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Flurbipr | 2016 |
Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling.
Topics: Administration, Oral; Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carr | 2016 |
Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory Effect.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drug Comp | 2016 |
Role of COX-2 in nonsteroidal anti-inflammatory drug enteropathy in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Dinoprostone; Flurbip | 2010 |
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corp | 2010 |
Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice.
Topics: Aging; Animals; Dopaminergic Neurons; Flurbiprofen; Inflammation; Lipopolysaccharides; Male; Mice; M | 2011 |
Inhibition of nuclear factor-kappaB by a nitro-derivative of flurbiprofen: a possible mechanism for antiinflammatory and antiproliferative effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Cell Line; Cell Nucleus; | 2003 |
Endotoxin inhibits the surge secretion of gonadotropin-releasing hormone via a prostaglandin-independent pathway.
Topics: Animals; Cyclooxygenase Inhibitors; Endotoxins; Estradiol; Female; Flurbiprofen; Follicular Phase; G | 2004 |
Responsiveness of C-fiber nociceptors to punctate force-controlled stimuli in isolated rat skin: lack of modulation by inflammatory mediators and flurbiprofen.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Hyperalgesia; In | 2004 |
Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology.
Topics: Acetylcholinesterase; Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti- | 2005 |
Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Gastric Muc | 2005 |
Beta-amyloid(1-42) induces a reduction in the parallel fiber responses of Purkinje cells: possible involvement of pro-inflammatory processes.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, N | 2007 |
In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents; Blood; Calcium Pyrophosphate; Chemotaxis, Leukocyte; Flurbiprofen | 1984 |
In vivo effects of indomethacin and flurbiprofen on the locomotion of neutrophils elicited by immune and non-immune inflammation in the rat.
Topics: Animals; Cell Movement; Flurbiprofen; Hypersensitivity; In Vitro Techniques; Indomethacin; Inflammat | 1984 |
Ultrasound has no anti-inflammatory effect.
Topics: Animals; Flurbiprofen; Inflammation; Irritants; Polyurethanes; Rats; Rats, Inbred Strains; Skin; Ult | 1983 |
A comparison of the ocular anti-inflammatory activity of steroidal and nonsteroidal compounds in the rat.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Evaluation, Preclinical; Eye Diseases; Flurbi | 1983 |
[Clinical experience with a molecule with anti-inflammatory action: flurbiprofen].
Topics: Adolescent; Adult; Cesarean Section; Edema; Episiotomy; Female; Flurbiprofen; Humans; Inflammation; | 1982 |
The anti-inflammatory and pharmacological effects of topically applied flurbiprofen on human skin 24 hours after ultraviolet B irradiation.
Topics: Adult; Aged; Arachidonic Acids; Erythema; Female; Flurbiprofen; Gas Chromatography-Mass Spectrometry | 1980 |
[Effect of non-steroidal anti-inflammatory drugs on inflammatory reaction. An animal experiment study].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns, Chemical; Conjunctiva; Cornea; Eye Burns; F | 1995 |
Study on paradoxical effects of NSAIDs on platelet activation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 12-Lipoxygenase; Aristolochic Acids; Calcium; | 1997 |
Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Casp | 2000 |
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; C | 2001 |
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; | 2001 |
Comparison of the effects of alclofenac, flurbiprofen, and prednisolone on acute inflammatory response in the rat.
Topics: Animals; Cell Movement; Exudates and Transudates; Flurbiprofen; Inflammation; Phenylacetates; Polyur | 1977 |
Separate anti-inflammatory effects of indomethacin, flurbiprofen and benoxaprofen.
Topics: Animals; Benzoxazoles; Flurbiprofen; Indomethacin; Inflammation; Leukocytes; Propionates; Prostaglan | 1977 |
The effect of anti-inflammatory and antirheumatic drugs on inflammation in the rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chronic Disease; Disease Models, Animal; Exudates | 1977 |
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap | 1975 |
Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antibodies; Capsaicin; Central Nervous S | 1991 |
Topical flurbiprofen in intraocular surgery on diabetic and nondiabetic patients.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Cataract; Cataract Extraction; Cyclooxygena | 1990 |
Physiology and treatment of pain and inflammation. Analgesic effects of flurbiprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Bradykinin; Brai | 1986 |
Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acute Disease; Animals; Blood Proteins | 1986 |
The contribution of cyclooxygenase and lipoxygenase products to acute inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Flurbiprofen; Indomethacin; | 1986 |
A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation.
Topics: Animals; Aqueous Humor; Capillary Permeability; Dinoprostone; Eye; Female; Flurbiprofen; Inflammatio | 1988 |
Differential in vivo effects of indomethacin, ibuprofen, and flurbiprofen on oxygen-dependent killing activities of neutrophils elicited by acute nonimmune inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Indomethacin; Inflammatio | 1988 |