flurbiprofen has been researched along with Gastric Ulcer in 16 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One gastric ulcer was seen in each of the 300- and 400-mg groups." | 6.67 | NSAID-induced gastric ulceration is dose related by weight: an endoscopic study with flurbiprofen. ( Lanza, FL; Royer, GL, 1993) |
| "(R)- flurbiprofen was not statistically significant." | 2.69 | Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial. ( Caubet, JF; Handley, DA; Jerussi, TP; McCray, JE, 1998) |
| "One gastric ulcer was seen in each of the 300- and 400-mg groups." | 2.67 | NSAID-induced gastric ulceration is dose related by weight: an endoscopic study with flurbiprofen. ( Lanza, FL; Royer, GL, 1993) |
| "Since assessment of the acute gastrotoxicity of nonsteroidal antiinflammatory drugs (NSAIDs) in rats requires high doses of the drugs, we sought to establish an experimental model with which this adverse NSAID effect can be estimated at therapy-relevant doses." | 1.31 | Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses. ( Cabré, F; Holzer, P; Jocic, M; Mauléon, D, 2001) |
| " Male Sprague-Dawley rats were dosed with two doses of metronidazole (50 mg/kg, 12 and 1 h pre-NSAID) or a single 100 mg/kg dose of tempo 1 h prior to NSAIDs." | 1.30 | Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers. ( Davies, NM; Jamali, F, 1997) |
| "Flurbiprofen (FP) was esterified with a histamine H2-antagonist, PPA (N-[3-(3-(1-piperidinylmethyl)phenoxy)-propyl]-2-(2- hydroxyethylthio)acetamide), to yield a chimera drug, FP-PPA, and its protective effect toward gastric lesions, other toxicities and the disposition kinetics were investigated, as compared to those of FP, in multiple oral administration to rats for 2 weeks." | 1.29 | Effect of oral multiple-dose administration of anti-inflammatory flurbiprofen chimera drug on gastric lesion, other toxicities and disposition kinetics. ( Fukuhara, A; Imai, T; Inoue, K; Otagiri, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amir, M | 3 |
| Kumar, H | 2 |
| Khan, SA | 2 |
| Javed, SA | 1 |
| Shrivastava, SK | 1 |
| Jain, DK | 1 |
| Trivedi, P | 1 |
| Kumar, S | 1 |
| Metwally, KA | 1 |
| Yaseen, SH | 1 |
| Lashine, el-SM | 1 |
| El-Fayomi, HM | 1 |
| El-Sadek, ME | 1 |
| Doğdaş, E | 1 |
| Tozkoparan, B | 1 |
| Kaynak, FB | 1 |
| Eriksson, L | 1 |
| Küpeli, E | 1 |
| Yeşilada, E | 1 |
| Ertan, M | 1 |
| Philip, AK | 1 |
| Dubey, RK | 1 |
| Pathak, K | 1 |
| Fukuhara, A | 1 |
| Imai, T | 1 |
| Inoue, K | 1 |
| Otagiri, M | 1 |
| Wallace, JL | 1 |
| Reuter, B | 1 |
| Cicala, C | 1 |
| McKnight, W | 1 |
| Grisham, MB | 1 |
| Cirino, G | 1 |
| Lanza, FL | 1 |
| Royer, GL | 1 |
| Davies, NM | 1 |
| Jamali, F | 1 |
| Jerussi, TP | 1 |
| Caubet, JF | 1 |
| McCray, JE | 1 |
| Handley, DA | 1 |
| Holzer, P | 1 |
| Jocic, M | 1 |
| Cabré, F | 1 |
| Mauléon, D | 1 |
| Ofuji, T | 1 |
| Kudo, M | 1 |
| Okumura, M | 2 |
| Kuriyama, K | 1 |
| Hiyama, Y | 1 |
| Aoyama, Y | 1 |
| Ichikawa, K | 1 |
| Masumoto, S | 1 |
| Ito, K | 1 |
| Ohtaki, Y | 1 |
| Hirata, M | 1 |
| Hanada, S | 1 |
| Marlow, CA | 1 |
2 trials available for flurbiprofen and Gastric Ulcer
| Article | Year |
|---|---|
NSAID-induced gastric ulceration is dose related by weight: an endoscopic study with flurbiprofen.
Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Drug Evaluation; Female; Flurbiprofen; Gastric | 1993 |
Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Dise | 1998 |
14 other studies available for flurbiprofen and Gastric Ulcer
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Lipid Peroxidation; Mole | 2008 |
1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carra | 2008 |
Dextrans--potential polymeric drug carriers for flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry, Physic | 2003 |
Synthesis of some new 2-(2-fluoro-4-biphenylyl)propionic acid derivatives as potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Edema; Female; Fl | 2005 |
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionat | 2007 |
Design and synthesis of some new thiazolo [3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Drug Desig | 2007 |
Optimizing delivery of flurbiprofen to the colon using a targeted prodrug approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Drug Delivery Systems; Female; Flurbiprofen | 2008 |
Effect of oral multiple-dose administration of anti-inflammatory flurbiprofen chimera drug on gastric lesion, other toxicities and disposition kinetics.
Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Blood Cell Count; B | 1995 |
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Flurbiprofen; Ketoprofen; Leukocyte | 1994 |
Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomar | 1997 |
Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
[Comparative studies on gastrointestinal damage induced by non-steroidal anti-inflammatory drugs in rats (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dose-Response Relationship, Drug; Flurbiprofen; Indometh | 1978 |
[Pharmacological studies of a non-steroidal analgesic and antipyretic drug of LFP83].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Flurbiprofen; Inje | 1989 |
Fluriprofen warning.
Topics: Animals; Dog Diseases; Dogs; Flurbiprofen; Propionates; Stomach Ulcer | 1987 |