Page last updated: 2024-10-27

flurbiprofen and Edema

flurbiprofen has been researched along with Edema in 36 studies

Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches."3.83Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model. ( Hori, M; Ichihara, T; Kaku, S; Matsumoto, H; Mitani, A; Otsuka, N; Sekine, S; Sugimoto, M; Toda, Y, 2016)
" No oedema and erythema were observed after administration of FP-NLC-gel on the rabbit skin, and the ovalbumin induced rat paw edema could be inhibited by the gel."3.78Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation. ( Che, X; Cui, Y; Han, F; Li, S; Yin, H; Yin, R; Yuan, J, 2012)
"Urethane anaesthesia strongly reduced the peripheral edema (31+/-5 and 96+/-8% reduction of carrageenan-enhanced paw and ankle diameters, respectively; P<0."3.71Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study. ( Besson, JM; Buritova, J, 2001)
" We have evaluated the effects of intravenous or intraplantar racemic-, S(+)- and R(-)-flurbiprofen on both the carrageenan-evoked peripheral oedema and spinal c-Fos immunoreactivity, an indirect index of neurons involved in spinal nociceptive processes."3.70Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord. ( Besson, JM; Buritova, J, 1998)
" It is concluded that the synthesized prodrugs have promising pharmacological activities with reduced GI adverse effects than the parent drug."1.43Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling. ( Abdullah, S; Ahsan, H; Ashraf, Z; Hassan, M; Kanwal, M; Kim, SJ; Waheed, M, 2016)
" The bioavailability of drug when administered as SD was evaluated in humans."1.33Formulation studies and in vivo evaluation of a flurbiprofen-hydroxypropyl beta-cyclodextrin system. ( Govindarajan, R; Nagarsenker, MS, 2005)
"Flurbiprofen (1) is an analgesic, antipyretic and antiinflammatory agent which is practically insoluble in water."1.30Formulation of an aqueous injection of flurbiprofen. ( Gupta, GD; Jain, NK; Jain, S, 1997)
"Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class."1.30Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. ( Diab, N; Domage, G; Dray, F; Mace, JL; Raguenes-Nicol, C; Russo-Marie, F; Solito, E; Streichenberger, G, 1999)
" The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid."1.25Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199010 (27.78)18.7374
1990's8 (22.22)18.2507
2000's7 (19.44)29.6817
2010's8 (22.22)24.3611
2020's3 (8.33)2.80

Authors

AuthorsStudies
Kumar, H1
Javed, SA1
Khan, SA1
Amir, M2
Palkar, MB1
Singhai, AS1
Ronad, PM1
Vishwanathswamy, AH1
Boreddy, TS1
Veerapur, VP1
Shaikh, MS1
Rane, RA1
Karpoormath, R1
Gurr, JR1
O'Donnell, TJ1
Luo, Y1
Yoshida, WY1
Hall, ML1
Mayer, AMS1
Sun, R1
Williams, PG1
Alam, A2
Ali, M2
Rehman, NU1
Latif, A2
Shah, AJ1
Wazir, NU1
Lodhi, MA1
Kamal, M1
Ayaz, M2
Al-Harrasi, A2
Ahmad, M2
Ur Rehman, N1
Jabbar Shah, A1
Amir Khan, I1
Ur Rahman, S1
Alshaikh, RA1
Essa, EA1
El Maghraby, GM1
Nitlikar, LH1
Sangshetti, JN1
Shinde, DB1
Sugimoto, M1
Toda, Y1
Hori, M1
Mitani, A1
Ichihara, T1
Sekine, S1
Kaku, S1
Otsuka, N1
Matsumoto, H1
Kaplan, V1
Eroğlu, CN1
Ashraf, Z1
Kanwal, M1
Hassan, M1
Abdullah, S1
Waheed, M1
Ahsan, H1
Kim, SJ1
Pandey, M1
Belgamwar, V1
Gattani, S1
Surana, S1
Tekade, A1
Han, F1
Yin, R1
Che, X1
Yuan, J1
Cui, Y1
Yin, H1
Li, S1
Shrivastava, SK1
Jain, DK1
Trivedi, P1
Govindarajan, R1
Nagarsenker, MS1
Kumar, S1
Doğdaş, E1
Tozkoparan, B1
Kaynak, FB1
Eriksson, L1
Küpeli, E1
Yeşilada, E1
Ertan, M1
Ambade, KW1
Jadhav, SL1
Gambhire, MN1
Kurmi, SD1
Kadam, VJ1
Jadhav, KR1
Bono, AV1
Roggia, A1
Berti, L1
Gerli, P1
Burdo, N1
Gaffen, Z1
Bland-Ward, PA1
Pitcher, A1
Wallace, P1
Moore, PK1
Dreiser, RL1
Roche, R1
De Sahb, R1
Thomas, F1
Leutenegger, E1
MacKay, K1
Gupta, GD1
Jain, S1
Jain, NK1
Steffen, H1
Böhm, C1
Auffarth, GU1
Kolling, GH1
Buritova, J2
Besson, JM2
Raguenes-Nicol, C1
Russo-Marie, F1
Domage, G1
Diab, N1
Solito, E1
Dray, F1
Mace, JL1
Streichenberger, G1
Masumoto, S3
Masuda, C2
Adams, SS1
McCullough, KF1
Nicholson, JS1
Takase, K1
Okumura, M1
Oga, S1
Taniguchi, SF1
Najjar, R1
Souza, AR1
Yamane, A1
Tokura, T1
Sano, T1
Miki, H1
Hahn, R1
Shimada, H1
Yagihashi, K1
Kawamura, A1
Koga, S1
Shingyouchi, F1
Hagita, K1
Matsui, M1
Sisk, AL1
Bonnington, GJ1

Trials

5 trials available for flurbiprofen and Edema

ArticleYear
Comparison of the Effects of Daily Single-Dose Use of Flurbiprofen, Diclofenac Sodium, and Tenoxicam on Postoperative Pain, Swelling, and Trismus: A Randomized Double-Blind Study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2016, Volume: 74, Issue:10

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anti-Inflammatory Agents, Non-Steroidal; D

2016
Flurbiprofen local action transcutaneous (LAT): clinical evaluation in the treatment of acute ankle sprains.
    European journal of rheumatology and inflammation, 1994, Volume: 14, Issue:4

    Topics: Acute Disease; Administration, Cutaneous; Adolescent; Adult; Aged; Ankle Injuries; Double-Blind Meth

1994
[Effect of a local nonsteroidal anti-inflammatory drug on postoperative irritation after squint surgeries. Prospective randomized double-blind study].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1997, Volume: 94, Issue:9

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Conjuncti

1997
Clinical evaluation of flurbiprofen alone and plus ampicillin in chronic pharyngitis in acute phase.
    International journal of clinical pharmacology research, 1986, Volume: 6, Issue:1

    Topics: Acute Disease; Adult; Aged; Ampicillin; Body Temperature; Clinical Trials as Topic; Drug Therapy, Co

1986
Evaluation of methylprednisolone and flurbiprofen for inhibition of the postoperative inflammatory response.
    Oral surgery, oral medicine, and oral pathology, 1985, Volume: 60, Issue:2

    Topics: Adolescent; Adult; Edema; Female; Flurbiprofen; Gingival Diseases; Humans; Male; Methylprednisolone;

1985

Other Studies

31 other studies available for flurbiprofen and Edema

ArticleYear
1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:12

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carra

2008
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2014, May-15, Volume: 22, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Computer Simulation; Cyclooxygenase 1

2014
6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.
    Journal of natural products, 2020, 05-22, Volume: 83, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Cyanobacteria; Diterpenes; Ear Diseases; Edema; Escherichia coli;

2020
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
    International journal of biological macromolecules, 2023, Feb-15, Volume: 228

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen

2023
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
    Bioorganic chemistry, 2023, Volume: 141

    Topics: Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxy

2023
Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator.
    International journal of pharmaceutics, 2019, May-30, Volume: 563

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carrageenan; Diclofenac; Dru

2019
Synthesis of some new flurbiprofen analogues as anti-inflammatory agents.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2014, Volume: 13, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Azoles; Edema; Female; Flurbiprofen; Male; Propionates; Rats

2014
Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model.
    Drug development research, 2016, Volume: 77, Issue:4

    Topics: Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis,

2016
Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling.
    Drug design, development and therapy, 2016, Volume: 10

    Topics: Administration, Oral; Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carr

2016
Pluronic lecithin organogel as a topical drug delivery system.
    Drug delivery, 2010, Volume: 17, Issue:1

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential

2010
Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation.
    International journal of pharmaceutics, 2012, Dec-15, Volume: 439, Issue:1-2

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Edema; Fat

2012
Dextrans--potential polymeric drug carriers for flurbiprofen.
    Die Pharmazie, 2003, Volume: 58, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry, Physic

2003
Formulation studies and in vivo evaluation of a flurbiprofen-hydroxypropyl beta-cyclodextrin system.
    Pharmaceutical development and technology, 2005, Volume: 10, Issue:1

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Chemistry, Pharmaceutical; Cross-Ove

2005
Synthesis of some new 2-(2-fluoro-4-biphenylyl)propionic acid derivatives as potential anti-inflammatory agents.
    Die Pharmazie, 2005, Volume: 60, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Edema; Female; Fl

2005
Design and synthesis of some new thiazolo [3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents.
    Arzneimittel-Forschung, 2007, Volume: 57, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Drug Desig

2007
Formulation and evaluation of flurbiprofen microemulsion.
    Current drug delivery, 2008, Volume: 5, Issue:1

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dioctyl Sulfosuccinic Aci

2008
The anti-inflammatory action of flurbiprofen suppositories in paediatric urology in comparison with co-trimoxazole.
    The Journal of international medical research, 1984, Volume: 12, Issue:2

    Topics: Anti-Inflammatory Agents; Child; Child, Preschool; Cryptorchidism; Drug Combinations; Edema; Flurbip

1984
[Clinical experience with a molecule with anti-inflammatory action: flurbiprofen].
    La Clinica terapeutica, 1982, Apr-15, Volume: 101, Issue:1

    Topics: Adolescent; Adult; Cesarean Section; Edema; Episiotomy; Female; Flurbiprofen; Humans; Inflammation;

1982
Augmented antinociception following 7-nitro indazole and flurbiprofen in the conscious mouse.
    European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3

    Topics: Amino Acid Oxidoreductases; Analgesics; Animals; Blood Pressure; Drug Synergism; Edema; Flurbiprofen

1994
Membranous nephropathy associated with the use of flurbiprofen.
    Clinical nephrology, 1997, Volume: 47, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Edema; Flurbiprofen; Glomerulonephritis, Membranous

1997
Formulation of an aqueous injection of flurbiprofen.
    Die Pharmazie, 1997, Volume: 52, Issue:9

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; D

1997
Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord.
    British journal of pharmacology, 1998, Volume: 125, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Flurbiprofen; Inje

1998
Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway.
    Biochemical pharmacology, 1999, Feb-15, Volume: 57, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyc

1999
Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study.
    Brain research, 2001, Feb-09, Volume: 891, Issue:1-2

    Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Count;

2001
[Mechanism of anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flurbiprofen)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1976, Volume: 72, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Dogs; Edema; Flurbiprofen; Hemolysis; Hot

1976
[Inhibitory effect of 2-(2-fluoro-4-biphenylyl)propionic acid (Flurbiprofen) on prostaglandin synthesis].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1976, Volume: 72, Issue:8

    Topics: Animals; Arachidonic Acids; Carrageenan; Chromatography, Thin Layer; Drug Synergism; Edema; Flurbipr

1976
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:11

    Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap

1975
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu

1975
Synthesis, characterization, and biological screening of a copper flurbiprofen complex with anti-inflammatory effects.
    Journal of inorganic biochemistry, 1991, Volume: 41, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Flurbiprofen; Gastric

1991
[The prostaglandin and the occurrence of corneal edema and neovascularization in anterior segmental ischemia induced in rabbit eyes].
    Nippon Ganka Gakkai zasshi, 1987, Volume: 91, Issue:11

    Topics: Animals; Anterior Eye Segment; Betamethasone; Cornea; Corneal Diseases; Drug Therapy, Combination; E

1987
[Effects of an anti-prostaglandin agent added to the irrigation solution on retinal edema in rabbit eyes induced by pars plana vitrectomy].
    Nippon Ganka Gakkai zasshi, 1987, Volume: 91, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Edema; Electroretinography; Flurbiprofen; Postoperative C

1987