flurbiprofen has been researched along with Edema in 36 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches." | 3.83 | Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model. ( Hori, M; Ichihara, T; Kaku, S; Matsumoto, H; Mitani, A; Otsuka, N; Sekine, S; Sugimoto, M; Toda, Y, 2016) |
| " No oedema and erythema were observed after administration of FP-NLC-gel on the rabbit skin, and the ovalbumin induced rat paw edema could be inhibited by the gel." | 3.78 | Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation. ( Che, X; Cui, Y; Han, F; Li, S; Yin, H; Yin, R; Yuan, J, 2012) |
| "Urethane anaesthesia strongly reduced the peripheral edema (31+/-5 and 96+/-8% reduction of carrageenan-enhanced paw and ankle diameters, respectively; P<0." | 3.71 | Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study. ( Besson, JM; Buritova, J, 2001) |
| " We have evaluated the effects of intravenous or intraplantar racemic-, S(+)- and R(-)-flurbiprofen on both the carrageenan-evoked peripheral oedema and spinal c-Fos immunoreactivity, an indirect index of neurons involved in spinal nociceptive processes." | 3.70 | Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord. ( Besson, JM; Buritova, J, 1998) |
| " It is concluded that the synthesized prodrugs have promising pharmacological activities with reduced GI adverse effects than the parent drug." | 1.43 | Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling. ( Abdullah, S; Ahsan, H; Ashraf, Z; Hassan, M; Kanwal, M; Kim, SJ; Waheed, M, 2016) |
| " The bioavailability of drug when administered as SD was evaluated in humans." | 1.33 | Formulation studies and in vivo evaluation of a flurbiprofen-hydroxypropyl beta-cyclodextrin system. ( Govindarajan, R; Nagarsenker, MS, 2005) |
| "Flurbiprofen (1) is an analgesic, antipyretic and antiinflammatory agent which is practically insoluble in water." | 1.30 | Formulation of an aqueous injection of flurbiprofen. ( Gupta, GD; Jain, NK; Jain, S, 1997) |
| "Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class." | 1.30 | Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. ( Diab, N; Domage, G; Dray, F; Mace, JL; Raguenes-Nicol, C; Russo-Marie, F; Solito, E; Streichenberger, G, 1999) |
| " The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid." | 1.25 | Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (27.78) | 18.7374 |
| 1990's | 8 (22.22) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 8 (22.22) | 24.3611 |
| 2020's | 3 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, H | 1 |
| Javed, SA | 1 |
| Khan, SA | 1 |
| Amir, M | 2 |
| Palkar, MB | 1 |
| Singhai, AS | 1 |
| Ronad, PM | 1 |
| Vishwanathswamy, AH | 1 |
| Boreddy, TS | 1 |
| Veerapur, VP | 1 |
| Shaikh, MS | 1 |
| Rane, RA | 1 |
| Karpoormath, R | 1 |
| Gurr, JR | 1 |
| O'Donnell, TJ | 1 |
| Luo, Y | 1 |
| Yoshida, WY | 1 |
| Hall, ML | 1 |
| Mayer, AMS | 1 |
| Sun, R | 1 |
| Williams, PG | 1 |
| Alam, A | 2 |
| Ali, M | 2 |
| Rehman, NU | 1 |
| Latif, A | 2 |
| Shah, AJ | 1 |
| Wazir, NU | 1 |
| Lodhi, MA | 1 |
| Kamal, M | 1 |
| Ayaz, M | 2 |
| Al-Harrasi, A | 2 |
| Ahmad, M | 2 |
| Ur Rehman, N | 1 |
| Jabbar Shah, A | 1 |
| Amir Khan, I | 1 |
| Ur Rahman, S | 1 |
| Alshaikh, RA | 1 |
| Essa, EA | 1 |
| El Maghraby, GM | 1 |
| Nitlikar, LH | 1 |
| Sangshetti, JN | 1 |
| Shinde, DB | 1 |
| Sugimoto, M | 1 |
| Toda, Y | 1 |
| Hori, M | 1 |
| Mitani, A | 1 |
| Ichihara, T | 1 |
| Sekine, S | 1 |
| Kaku, S | 1 |
| Otsuka, N | 1 |
| Matsumoto, H | 1 |
| Kaplan, V | 1 |
| Eroğlu, CN | 1 |
| Ashraf, Z | 1 |
| Kanwal, M | 1 |
| Hassan, M | 1 |
| Abdullah, S | 1 |
| Waheed, M | 1 |
| Ahsan, H | 1 |
| Kim, SJ | 1 |
| Pandey, M | 1 |
| Belgamwar, V | 1 |
| Gattani, S | 1 |
| Surana, S | 1 |
| Tekade, A | 1 |
| Han, F | 1 |
| Yin, R | 1 |
| Che, X | 1 |
| Yuan, J | 1 |
| Cui, Y | 1 |
| Yin, H | 1 |
| Li, S | 1 |
| Shrivastava, SK | 1 |
| Jain, DK | 1 |
| Trivedi, P | 1 |
| Govindarajan, R | 1 |
| Nagarsenker, MS | 1 |
| Kumar, S | 1 |
| Doğdaş, E | 1 |
| Tozkoparan, B | 1 |
| Kaynak, FB | 1 |
| Eriksson, L | 1 |
| Küpeli, E | 1 |
| Yeşilada, E | 1 |
| Ertan, M | 1 |
| Ambade, KW | 1 |
| Jadhav, SL | 1 |
| Gambhire, MN | 1 |
| Kurmi, SD | 1 |
| Kadam, VJ | 1 |
| Jadhav, KR | 1 |
| Bono, AV | 1 |
| Roggia, A | 1 |
| Berti, L | 1 |
| Gerli, P | 1 |
| Burdo, N | 1 |
| Gaffen, Z | 1 |
| Bland-Ward, PA | 1 |
| Pitcher, A | 1 |
| Wallace, P | 1 |
| Moore, PK | 1 |
| Dreiser, RL | 1 |
| Roche, R | 1 |
| De Sahb, R | 1 |
| Thomas, F | 1 |
| Leutenegger, E | 1 |
| MacKay, K | 1 |
| Gupta, GD | 1 |
| Jain, S | 1 |
| Jain, NK | 1 |
| Steffen, H | 1 |
| Böhm, C | 1 |
| Auffarth, GU | 1 |
| Kolling, GH | 1 |
| Buritova, J | 2 |
| Besson, JM | 2 |
| Raguenes-Nicol, C | 1 |
| Russo-Marie, F | 1 |
| Domage, G | 1 |
| Diab, N | 1 |
| Solito, E | 1 |
| Dray, F | 1 |
| Mace, JL | 1 |
| Streichenberger, G | 1 |
| Masumoto, S | 3 |
| Masuda, C | 2 |
| Adams, SS | 1 |
| McCullough, KF | 1 |
| Nicholson, JS | 1 |
| Takase, K | 1 |
| Okumura, M | 1 |
| Oga, S | 1 |
| Taniguchi, SF | 1 |
| Najjar, R | 1 |
| Souza, AR | 1 |
| Yamane, A | 1 |
| Tokura, T | 1 |
| Sano, T | 1 |
| Miki, H | 1 |
| Hahn, R | 1 |
| Shimada, H | 1 |
| Yagihashi, K | 1 |
| Kawamura, A | 1 |
| Koga, S | 1 |
| Shingyouchi, F | 1 |
| Hagita, K | 1 |
| Matsui, M | 1 |
| Sisk, AL | 1 |
| Bonnington, GJ | 1 |
5 trials available for flurbiprofen and Edema
| Article | Year |
|---|---|
Comparison of the Effects of Daily Single-Dose Use of Flurbiprofen, Diclofenac Sodium, and Tenoxicam on Postoperative Pain, Swelling, and Trismus: A Randomized Double-Blind Study.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anti-Inflammatory Agents, Non-Steroidal; D | 2016 |
Flurbiprofen local action transcutaneous (LAT): clinical evaluation in the treatment of acute ankle sprains.
Topics: Acute Disease; Administration, Cutaneous; Adolescent; Adult; Aged; Ankle Injuries; Double-Blind Meth | 1994 |
[Effect of a local nonsteroidal anti-inflammatory drug on postoperative irritation after squint surgeries. Prospective randomized double-blind study].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Conjuncti | 1997 |
Clinical evaluation of flurbiprofen alone and plus ampicillin in chronic pharyngitis in acute phase.
Topics: Acute Disease; Adult; Aged; Ampicillin; Body Temperature; Clinical Trials as Topic; Drug Therapy, Co | 1986 |
Evaluation of methylprednisolone and flurbiprofen for inhibition of the postoperative inflammatory response.
Topics: Adolescent; Adult; Edema; Female; Flurbiprofen; Gingival Diseases; Humans; Male; Methylprednisolone; | 1985 |
31 other studies available for flurbiprofen and Edema
| Article | Year |
|---|---|
1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carra | 2008 |
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Computer Simulation; Cyclooxygenase 1 | 2014 |
6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.
Topics: Animals; Anti-Inflammatory Agents; Cyanobacteria; Diterpenes; Ear Diseases; Edema; Escherichia coli; | 2020 |
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2023 |
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Topics: Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxy | 2023 |
Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carrageenan; Diclofenac; Dru | 2019 |
Synthesis of some new flurbiprofen analogues as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Azoles; Edema; Female; Flurbiprofen; Male; Propionates; Rats | 2014 |
Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model.
Topics: Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 2016 |
Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling.
Topics: Administration, Oral; Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carr | 2016 |
Pluronic lecithin organogel as a topical drug delivery system.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential | 2010 |
Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Edema; Fat | 2012 |
Dextrans--potential polymeric drug carriers for flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry, Physic | 2003 |
Formulation studies and in vivo evaluation of a flurbiprofen-hydroxypropyl beta-cyclodextrin system.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Chemistry, Pharmaceutical; Cross-Ove | 2005 |
Synthesis of some new 2-(2-fluoro-4-biphenylyl)propionic acid derivatives as potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Edema; Female; Fl | 2005 |
Design and synthesis of some new thiazolo [3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Drug Desig | 2007 |
Formulation and evaluation of flurbiprofen microemulsion.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dioctyl Sulfosuccinic Aci | 2008 |
The anti-inflammatory action of flurbiprofen suppositories in paediatric urology in comparison with co-trimoxazole.
Topics: Anti-Inflammatory Agents; Child; Child, Preschool; Cryptorchidism; Drug Combinations; Edema; Flurbip | 1984 |
[Clinical experience with a molecule with anti-inflammatory action: flurbiprofen].
Topics: Adolescent; Adult; Cesarean Section; Edema; Episiotomy; Female; Flurbiprofen; Humans; Inflammation; | 1982 |
Augmented antinociception following 7-nitro indazole and flurbiprofen in the conscious mouse.
Topics: Amino Acid Oxidoreductases; Analgesics; Animals; Blood Pressure; Drug Synergism; Edema; Flurbiprofen | 1994 |
Membranous nephropathy associated with the use of flurbiprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Edema; Flurbiprofen; Glomerulonephritis, Membranous | 1997 |
Formulation of an aqueous injection of flurbiprofen.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; D | 1997 |
Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Flurbiprofen; Inje | 1998 |
Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyc | 1999 |
Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study.
Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Count; | 2001 |
[Mechanism of anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flurbiprofen)].
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Dogs; Edema; Flurbiprofen; Hemolysis; Hot | 1976 |
[Inhibitory effect of 2-(2-fluoro-4-biphenylyl)propionic acid (Flurbiprofen) on prostaglandin synthesis].
Topics: Animals; Arachidonic Acids; Carrageenan; Chromatography, Thin Layer; Drug Synergism; Edema; Flurbipr | 1976 |
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap | 1975 |
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu | 1975 |
Synthesis, characterization, and biological screening of a copper flurbiprofen complex with anti-inflammatory effects.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Flurbiprofen; Gastric | 1991 |
[The prostaglandin and the occurrence of corneal edema and neovascularization in anterior segmental ischemia induced in rabbit eyes].
Topics: Animals; Anterior Eye Segment; Betamethasone; Cornea; Corneal Diseases; Drug Therapy, Combination; E | 1987 |
[Effects of an anti-prostaglandin agent added to the irrigation solution on retinal edema in rabbit eyes induced by pars plana vitrectomy].
Topics: Animals; Dose-Response Relationship, Drug; Edema; Electroretinography; Flurbiprofen; Postoperative C | 1987 |