flurbiprofen has been researched along with Brain Ischemia in 6 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure." | 8.12 | Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9. ( Nie, Y; Wang, L; Xiong, W; Yang, B, 2022) |
| "Our previous papers indicate that flurbiprofen axetil (FA), a cyclooxygenase inhibitor, is a promising therapeutic strategy for cerebral ischemia in rats." | 7.78 | Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. ( Jin, JW; Liu, JL; Pei, SJ; Wang, C, 2012) |
| "Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury." | 5.48 | Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018) |
| "Flurbiprofen has been shown to reduce cerebral ischemia/reperfusion injury in both focal and global cerebral ischemia models, but the mechanism remains unclear." | 5.37 | The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. ( Chen, L; Liu, X; Sun, B; Wei, X; Xiang, Y; Zhang, X, 2011) |
| "The modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure." | 4.12 | Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9. ( Nie, Y; Wang, L; Xiong, W; Yang, B, 2022) |
| "Our previous papers indicate that flurbiprofen axetil (FA), a cyclooxygenase inhibitor, is a promising therapeutic strategy for cerebral ischemia in rats." | 3.78 | Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. ( Jin, JW; Liu, JL; Pei, SJ; Wang, C, 2012) |
| " In this context, we analyzed the effect of Ifenprodil, an NR2b selective NMDAR antagonist and its combination at lower doses with flurbiprofen, a selective ASIC1a inhibitor on rat model of focal cerebral ischemia." | 3.77 | The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. ( Mishra, V; Raghubir, R; Singh, N; Verma, R, 2011) |
| "Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury." | 1.48 | Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018) |
| "Flurbiprofen has been shown to reduce cerebral ischemia/reperfusion injury in both focal and global cerebral ischemia models, but the mechanism remains unclear." | 1.37 | The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. ( Chen, L; Liu, X; Sun, B; Wei, X; Xiang, Y; Zhang, X, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, B | 1 |
| Nie, Y | 1 |
| Wang, L | 1 |
| Xiong, W | 1 |
| Wu, H | 1 |
| Tang, C | 1 |
| Tai, LW | 1 |
| Yao, W | 1 |
| Guo, P | 1 |
| Hong, J | 1 |
| Yang, X | 1 |
| Li, X | 1 |
| Jin, Z | 1 |
| Ke, J | 1 |
| Wang, Y | 1 |
| Kapoor, S | 1 |
| Mishra, V | 1 |
| Verma, R | 1 |
| Singh, N | 1 |
| Raghubir, R | 1 |
| Sun, B | 1 |
| Chen, L | 1 |
| Wei, X | 1 |
| Xiang, Y | 1 |
| Liu, X | 1 |
| Zhang, X | 1 |
| Liu, JL | 1 |
| Jin, JW | 1 |
| Pei, SJ | 1 |
| Wang, C | 1 |
6 other studies available for flurbiprofen and Brain Ischemia
| Article | Year |
|---|---|
Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9.
Topics: Animals; Brain; Brain Ischemia; Cytokines; Disease Models, Animal; Flurbiprofen; Male; Malondialdehy | 2022 |
Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Flurbiprof | 2018 |
Flurbiprofen and its attenuating effect on intracranial ischemic injury as well as ischemia in other systemic organs.
Topics: Animals; Brain Ischemia; Cyclooxygenase Inhibitors; Flurbiprofen; Male; Neuroprotective Agents; PPAR | 2013 |
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury.
Topics: Animals; Apoptosis; Brain Ischemia; Drug Therapy, Combination; Flurbiprofen; In Situ Nick-End Labeli | 2011 |
The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain Ischemia; Cytoprotection; Flurbip | 2011 |
Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cyclooxygenase Inhibitors; Flurbiprofen; Male; Neuroprotective Agents; PPAR | 2012 |