Page last updated: 2024-10-27

flurbiprofen and Brain Ischemia

flurbiprofen has been researched along with Brain Ischemia in 6 studies

Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"The modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure."8.12Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9. ( Nie, Y; Wang, L; Xiong, W; Yang, B, 2022)
"Our previous papers indicate that flurbiprofen axetil (FA), a cyclooxygenase inhibitor, is a promising therapeutic strategy for cerebral ischemia in rats."7.78Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. ( Jin, JW; Liu, JL; Pei, SJ; Wang, C, 2012)
"Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury."5.48Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018)
"Flurbiprofen has been shown to reduce cerebral ischemia/reperfusion injury in both focal and global cerebral ischemia models, but the mechanism remains unclear."5.37The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. ( Chen, L; Liu, X; Sun, B; Wei, X; Xiang, Y; Zhang, X, 2011)
"The modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure."4.12Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9. ( Nie, Y; Wang, L; Xiong, W; Yang, B, 2022)
"Our previous papers indicate that flurbiprofen axetil (FA), a cyclooxygenase inhibitor, is a promising therapeutic strategy for cerebral ischemia in rats."3.78Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. ( Jin, JW; Liu, JL; Pei, SJ; Wang, C, 2012)
" In this context, we analyzed the effect of Ifenprodil, an NR2b selective NMDAR antagonist and its combination at lower doses with flurbiprofen, a selective ASIC1a inhibitor on rat model of focal cerebral ischemia."3.77The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. ( Mishra, V; Raghubir, R; Singh, N; Verma, R, 2011)
"Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury."1.48Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. ( Guo, P; Hong, J; Jin, Z; Ke, J; Li, X; Tai, LW; Tang, C; Wang, Y; Wu, H; Yang, X; Yao, W, 2018)
"Flurbiprofen has been shown to reduce cerebral ischemia/reperfusion injury in both focal and global cerebral ischemia models, but the mechanism remains unclear."1.37The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. ( Chen, L; Liu, X; Sun, B; Wei, X; Xiang, Y; Zhang, X, 2011)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Yang, B1
Nie, Y1
Wang, L1
Xiong, W1
Wu, H1
Tang, C1
Tai, LW1
Yao, W1
Guo, P1
Hong, J1
Yang, X1
Li, X1
Jin, Z1
Ke, J1
Wang, Y1
Kapoor, S1
Mishra, V1
Verma, R1
Singh, N1
Raghubir, R1
Sun, B1
Chen, L1
Wei, X1
Xiang, Y1
Liu, X1
Zhang, X1
Liu, JL1
Jin, JW1
Pei, SJ1
Wang, C1

Other Studies

6 other studies available for flurbiprofen and Brain Ischemia

ArticleYear
Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9.
    Chemical biology & drug design, 2022, Volume: 99, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Cytokines; Disease Models, Animal; Flurbiprofen; Male; Malondialdehy

2022
Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion.
    Bioscience reports, 2018, 08-31, Volume: 38, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Flurbiprof

2018
Flurbiprofen and its attenuating effect on intracranial ischemic injury as well as ischemia in other systemic organs.
    Chinese medical journal, 2013, Volume: 126, Issue:3

    Topics: Animals; Brain Ischemia; Cyclooxygenase Inhibitors; Flurbiprofen; Male; Neuroprotective Agents; PPAR

2013
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury.
    Brain research, 2011, May-10, Volume: 1389

    Topics: Animals; Apoptosis; Brain Ischemia; Drug Therapy, Combination; Flurbiprofen; In Situ Nick-End Labeli

2011
The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats.
    Biochemical and biophysical research communications, 2011, Jun-17, Volume: 409, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain Ischemia; Cytoprotection; Flurbip

2011
Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats.
    Chinese medical journal, 2012, Volume: 125, Issue:20

    Topics: Animals; Brain Ischemia; Cyclooxygenase Inhibitors; Flurbiprofen; Male; Neuroprotective Agents; PPAR

2012