flurbiprofen has been researched along with Bone Loss, Osteoclastic in 26 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have shown that the prostaglandin synthesis inhibitor indomethacin reduced osteolysis produced by the experimental VX2 carcinoma, probably by inhibiting the stimulation of osteoclasts by prostaglandin E2." | 3.66 | The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis. ( Galasko, CS; Lacey, E; Rushton, S; Samuel, AW, 1980) |
| "This suggests that HCT1026 inhibits bone resorption by inhibiting the effects of RANKL." | 1.35 | The nitrosylated flurbiprofen derivative HCT1026 inhibits cytokine-induced signalling through a novel mechanism of action. ( Idris, AI; Ralston, SH; van't Hof, RJ, 2009) |
| "This increase in bone resorption was additive to the resorptive effect resulting from the addition of 10(-9)-10(-7) M parathyroid hormone (PTH), but was not additive to similar effects produced by the addition of 10(-9)-10(-7) M prostaglandin E2 (PGE2)." | 1.30 | In vitro bone resorption is dependent on physiological concentrations of zinc. ( Chen, D; Pierce, WM; Waite, LC, 1998) |
| "In indomethacin-treated bones, however, caffeine potentiated the stimulatory effect on 45Ca release induced by choleratoxin and forskolin." | 1.28 | Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria. ( Lerner, UH; Mellström, D, 1992) |
| " This investigation focuses on the changes in CO metabolites which occur during disease progression of ligature-induced periodontitis and on the dose-response relationship of flurbiprofen, as it relates to disease inhibition and the suppression of ARA metabolites within the crevicular fluid (CF)." | 1.28 | Changes in cyclooxygenase metabolites in experimental periodontitis in Macaca mulatta. ( Braswell, LD; Green, MD; Hall, CM; Johnson, HG; McClure, H; Odle, BM; Offenbacher, S; Orkin, JL; Strobert, EA, 1989) |
| "Flurbiprofen was given subcutaneously at 0, 0." | 1.27 | Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats. ( Jee, WS; Li, XJ; Li, YL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (53.85) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Idris, AI | 2 |
| Ralston, SH | 3 |
| van't Hof, RJ | 2 |
| Del Soldato, P | 2 |
| Williams, RC | 11 |
| Jeffcoat, MK | 10 |
| Wechter, WJ | 5 |
| Johnson, HG | 7 |
| Kaplan, ML | 5 |
| Goldhaber, P | 9 |
| Galasko, CS | 1 |
| Samuel, AW | 1 |
| Rushton, S | 1 |
| Lacey, E | 1 |
| Kizior, MJ | 1 |
| Chai, JY | 2 |
| Turner, DW | 2 |
| Stern, PH | 2 |
| Messerli, LS | 1 |
| Howell, TH | 5 |
| Gallwitz, WE | 1 |
| Mundy, GR | 1 |
| Lee, CH | 1 |
| Qiao, M | 1 |
| Roodman, GD | 1 |
| Raftery, M | 1 |
| Gaskell, SJ | 1 |
| Bonewald, LF | 1 |
| Chen, D | 1 |
| Waite, LC | 1 |
| Pierce, WM | 1 |
| Kawaguchi, H | 1 |
| Chikazu, D | 1 |
| Nakamura, K | 1 |
| Kumegawa, M | 1 |
| Hakeda, Y | 1 |
| Mitchell, ME | 1 |
| Stern, LS | 1 |
| Shah, N | 1 |
| Ostrum, R | 1 |
| Armour, KJ | 1 |
| van 't Hof, RJ | 1 |
| Armour, KE | 1 |
| Torbergsen, AC | 1 |
| Coombes, RC | 1 |
| Neville, AM | 1 |
| Gazet, JC | 1 |
| Ford, HT | 1 |
| Nash, AG | 1 |
| Baker, JW | 1 |
| Powles, JT | 1 |
| Lerner, UH | 2 |
| Mellström, D | 1 |
| Ljunggren, O | 1 |
| Dewhirst, FE | 1 |
| Boraschi, D | 1 |
| Offenbacher, S | 2 |
| Odle, BM | 1 |
| Braswell, LD | 1 |
| Hall, CM | 4 |
| McClure, H | 1 |
| Orkin, JL | 1 |
| Strobert, EA | 1 |
| Green, MD | 1 |
| Rolla, A | 1 |
| Stubbs, D | 1 |
| Teoh, KW | 1 |
| Reddy, MS | 2 |
| Gandrup, JS | 1 |
| Jee, WS | 1 |
| Li, XJ | 1 |
| Li, YL | 1 |
1 review available for flurbiprofen and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; | 1993 |
1 trial available for flurbiprofen and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen.
Topics: Adult; Aged; Bone Resorption; Dental Scaling; Double-Blind Method; Female; Flurbiprofen; Humans; Ima | 1989 |
24 other studies available for flurbiprofen and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
The nitrosylated flurbiprofen derivative HCT1026 inhibits cytokine-induced signalling through a novel mechanism of action.
Topics: Actins; Animals; Apoptosis; Bone Resorption; Cytokines; Enzyme Activation; Flurbiprofen; Mice; Mitog | 2009 |
The flurbiprofen derivatives HCT1026 and HCT1027 inhibit bone resorption by a mechanism independent of COX inhibition and nitric oxide production.
Topics: Animals; Bone Resorption; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Dr | 2004 |
Non-steroidal anti-inflammatory drug treatment of periodontitis in beagles.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Female; Flurbiprofen; Periodontal Diseases; Propio | 1984 |
The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis.
Topics: Animals; Bone Resorption; Breast Neoplasms; Culture Techniques; Diphosphonates; Flurbiprofen; Humans | 1980 |
Flurbiprofen effects on bone resorption.
Topics: Analysis of Variance; Animals; Bone and Bones; Bone Resorption; Disease Models, Animal; Fetus; Flurb | 1993 |
Effects of high concentrations of flurbiprofen on bone remodeling in neonatal mouse calvaria.
Topics: Analysis of Variance; Animals; Bone Remodeling; Bone Resorption; Collagen; Flurbiprofen; Mice; Prost | 1993 |
5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices.
Topics: Acid Phosphatase; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Bone Matrix; Bone Resorpt | 1993 |
In vitro bone resorption is dependent on physiological concentrations of zinc.
Topics: Acid Phosphatase; Animals; Bone Resorption; Calcium; Chelating Agents; Chick Embryo; Cyclooxygenase | 1998 |
Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures.
Topics: Acid Phosphatase; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Bo | 2000 |
Effect of flurbiprofen on hind-limb suspension-induced bone loss.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Bone Density; Bone Resorption; Flurbi | 2001 |
Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester (HCT1026).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Cell Division; Cells, Cultured; D | 2001 |
Agents affecting osteolysis in patients with breast cancer.
Topics: Anti-Inflammatory Agents; Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcitonin; Fe | 1979 |
Caffeine has the capacity to stimulate calcium release in organ culture of neonatal mouse calvaria.
Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Caffeine; Calcium; Dose-Response Relatio | 1992 |
Comparison of human interleukin-1 beta and its 163-171 peptide in bone resorption and the immune response.
Topics: Amino Acid Sequence; Animals; Antibody Formation; Bone and Bones; Bone Resorption; Bradykinin; Calci | 1991 |
Changes in cyclooxygenase metabolites in experimental periodontitis in Macaca mulatta.
Topics: Animals; Arachidonic Acids; Bone Resorption; Cyclooxygenase Inhibitors; Dental Plaque Index; Epithel | 1989 |
Flurbiprofen treatment of periodontal disease in beagles.
Topics: Animals; Bone Resorption; Dogs; Flurbiprofen; Periodontal Diseases; Periodontal Index; Propionates; | 1986 |
Indomethacin or flurbiprofen treatment of periodontitis in beagles: comparison of effect on bone loss.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Female; Flurbiprofen; Indomethacin; Periodontal Di | 1987 |
Indomethacin or flurbiprofen treatment of periodontitis in beagles: effect on crevicular fluid arachidonic acid metabolites compared with effect on alveolar bone loss.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bone Resorption; Cyclooxygenase Inhibitors; Dogs; Fema | 1988 |
Topical flurbiprofen treatment of periodontitis in beagles.
Topics: Administration, Topical; Animals; Bone Resorption; Dogs; Female; Flurbiprofen; Periodontitis; Propio | 1988 |
Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats.
Topics: Age Factors; Animals; Bone Resorption; Female; Flurbiprofen; Osteogenesis; Periosteum; Propionates; | 1988 |
Treating periodontal disease.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Flurbiprofen; Periodontal Diseases; Propionates | 1986 |
Nuclear medicine techniques for the detection of active alveolar bone loss.
Topics: Alveolar Process; Animals; Bone Resorption; Diet; Dogs; Female; Flurbiprofen; Humans; Male; Periodon | 1987 |
Nuclear medicine. An indicator of "active" alveolar bone loss in beagle dogs treated with nonsteroidal anti-inflammatory drug.
Topics: Alveolar Process; Animals; Bone Resorption; Dental Scaling; Dogs; Flurbiprofen; Periodontal Diseases | 1985 |
Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Female; Flurbiprofen; Humans; Periodontal Diseases | 1985 |