flurbiprofen has been researched along with Body Weight in 21 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One gastric ulcer was seen in each of the 300- and 400-mg groups." | 6.67 | NSAID-induced gastric ulceration is dose related by weight: an endoscopic study with flurbiprofen. ( Lanza, FL; Royer, GL, 1993) |
| " Only minor differences in the pharmacokinetic parameters were observed between the younger and elderly patients." | 6.67 | The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis. ( Antal, EJ; Buchanan, WW; Cauvier, H; Grace, EM; Kean, WF; Rischke, J, 1992) |
| "Potential benefits of combining docosahexaenoic acid (DHA), an omega-3 fatty acid with flurbiprofen (Flu), a non-steroidal anti-inflammatory drug in ameliorating obesity remain to be elucidated." | 3.91 | Docosahexaenoic acid-flurbiprofen combination ameliorates metaflammation in rats fed on high-carbohydrate high-fat diet. ( Al-Ashmawy, GM; El-Ashmawy, NE; Kamel, AA, 2019) |
| "Male Lewis rats (n = 78) were randomly assigned to one of 10 groups, comprising controls, adjuvant arthritis (AA), and adjuvant arthritis with various combinations of 2 chemically modified, non-antimicrobial tetracycline derivatives (CMT3 or CMT8) with either of 2 nonsteroidal antiinflammatory agents (flurbiprofen or tenidap)." | 3.69 | Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis. ( Golub, LM; Greenwald, RA; Leng, W; Moak, SA; Wohl, GR; Zernicke, RF, 1997) |
| "In patients with mild hypertension, flurbiprofen in a dose of 100 mg daily for 7 days attenuated the hypotensive effect of a single dose of propranolol 80 mg but not of atenolol 100 mg." | 3.67 | Flurbiprofen interaction with single doses of atenolol and propranolol. ( Hawksworth, GM; McLean, I; Petrie, JC; Webster, J, 1984) |
| "One gastric ulcer was seen in each of the 300- and 400-mg groups." | 2.67 | NSAID-induced gastric ulceration is dose related by weight: an endoscopic study with flurbiprofen. ( Lanza, FL; Royer, GL, 1993) |
| " Renal function was assessed in eight patients with chronic renal insufficiency following the administration of flurbiprofen 50 mg as a single dose and after chronic administration of 50 mg four times daily for 8 and 27 days." | 2.67 | Effects of flurbiprofen on renal function in patients with moderate renal insufficiency. ( Brater, DC; Greene, PK; Hall, SD; Manatunga, AK; Murray, MD, 1992) |
| " Only minor differences in the pharmacokinetic parameters were observed between the younger and elderly patients." | 2.67 | The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis. ( Antal, EJ; Buchanan, WW; Cauvier, H; Grace, EM; Kean, WF; Rischke, J, 1992) |
| "The paper is to report the establishment of a population pharmacokinetic model for flurbiprofen (FP), an active metabolite of flurbiprofen axetil (FA)." | 1.36 | [Population pharmacokinetic modeling of flurbiprofen]. ( Gong, SJ; Huang, PF; Lin, WW; Wang, CL, 2010) |
| " We infused the proinflammagen lipopolysaccharide into the basal forebrain of young rats and determined whether the chronic administration of two novel non-steroidal anti-inflammatory drugs or a pan-caspase synthesis inhibitor, z-Val-Ala-Asp(OMe)-fluoromethyl ketone (zVAD), could provide neuroprotection from the cytotoxic effects of the neuroinflammation." | 1.31 | Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. ( Del Soldato, P; Fiorucci, S; Hauss-Wegrzyniak, B; McGann, K; Mencarelli, A; Wenk, GL, 2000) |
| "Flurbiprofen (FP) was esterified with a histamine H2-antagonist, PPA (N-[3-(3-(1-piperidinylmethyl)phenoxy)-propyl]-2-(2- hydroxyethylthio)acetamide), to yield a chimera drug, FP-PPA, and its protective effect toward gastric lesions, other toxicities and the disposition kinetics were investigated, as compared to those of FP, in multiple oral administration to rats for 2 weeks." | 1.29 | Effect of oral multiple-dose administration of anti-inflammatory flurbiprofen chimera drug on gastric lesion, other toxicities and disposition kinetics. ( Fukuhara, A; Imai, T; Inoue, K; Otagiri, M, 1995) |
| "The first squamous cell carcinomas of the forestomach were detected on day 51." | 1.27 | Effect of flurbiprofen and 16,16-dimethyl-prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. I. Squamous epithelium and mesenchymal tissue. ( DeCosse, JJ; Deschner, EE; Karmali, RA; Lehnert, T, 1987) |
| " Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents." | 1.26 | Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. ( Bennett, A; Berstock, DA; Carroll, MA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 11 (52.38) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Ashmawy, NE | 1 |
| Al-Ashmawy, GM | 1 |
| Kamel, AA | 1 |
| Wang, CL | 1 |
| Lin, WW | 1 |
| Gong, SJ | 1 |
| Huang, PF | 1 |
| Törnkvist, H | 1 |
| Nilsson, OS | 1 |
| Bauer, FC | 1 |
| Lindholm, TS | 1 |
| Webster, J | 1 |
| Petrie, JC | 1 |
| McLean, I | 1 |
| Hawksworth, GM | 1 |
| Bennett, A | 1 |
| Berstock, DA | 1 |
| Carroll, MA | 1 |
| Fukuhara, A | 1 |
| Imai, T | 1 |
| Inoue, K | 1 |
| Otagiri, M | 1 |
| Cameron, NE | 2 |
| Cotter, MA | 2 |
| Dines, KC | 1 |
| Robertson, S | 1 |
| Cox, D | 1 |
| Lanza, FL | 1 |
| Royer, GL | 1 |
| Hohman, TC | 1 |
| Uchida, S | 1 |
| Morishita, T | 1 |
| Ikeda, Y | 1 |
| Akashi, T | 1 |
| Roe, SY | 1 |
| Cooper, AL | 1 |
| Morris, ID | 1 |
| Rothwell, NJ | 1 |
| Zernicke, RF | 1 |
| Wohl, GR | 1 |
| Greenwald, RA | 1 |
| Moak, SA | 1 |
| Leng, W | 1 |
| Golub, LM | 1 |
| Wechter, WJ | 2 |
| Kantoci, D | 1 |
| Murray, ED | 2 |
| Quiggle, DD | 1 |
| Leipold, DD | 2 |
| Gibson, KM | 1 |
| McCracken, JD | 2 |
| Quiggle, D | 1 |
| Barrios, RS | 1 |
| Greenberg, NM | 1 |
| Wenk, GL | 1 |
| McGann, K | 1 |
| Mencarelli, A | 1 |
| Hauss-Wegrzyniak, B | 1 |
| Del Soldato, P | 1 |
| Fiorucci, S | 1 |
| Mitchell, ME | 1 |
| Stern, LS | 1 |
| Shah, N | 1 |
| Ostrum, R | 1 |
| Murray, MD | 1 |
| Greene, PK | 1 |
| Brater, DC | 1 |
| Manatunga, AK | 1 |
| Hall, SD | 1 |
| Kean, WF | 1 |
| Antal, EJ | 1 |
| Grace, EM | 1 |
| Cauvier, H | 1 |
| Rischke, J | 1 |
| Buchanan, WW | 1 |
| Lehnert, T | 2 |
| Deschner, EE | 2 |
| Karmali, RA | 2 |
| DeCosse, JJ | 2 |
| Li, XJ | 1 |
| Jee, WS | 1 |
| Li, YL | 1 |
3 trials available for flurbiprofen and Body Weight
| Article | Year |
|---|---|
NSAID-induced gastric ulceration is dose related by weight: an endoscopic study with flurbiprofen.
Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Drug Evaluation; Female; Flurbiprofen; Gastric | 1993 |
Effects of flurbiprofen on renal function in patients with moderate renal insufficiency.
Topics: Aged; Blood Pressure; Body Weight; Female; Flurbiprofen; Hemodynamics; Humans; Indomethacin; Kidney; | 1992 |
The pharmacokinetics of flurbiprofen in younger and elderly patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bo | 1992 |
18 other studies available for flurbiprofen and Body Weight
| Article | Year |
|---|---|
Docosahexaenoic acid-flurbiprofen combination ameliorates metaflammation in rats fed on high-carbohydrate high-fat diet.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Diet, | 2019 |
[Population pharmacokinetic modeling of flurbiprofen].
Topics: Adult; Aged; Analgesics; Body Weight; Female; Flurbiprofen; Head and Neck Neoplasms; Humans; Injecti | 2010 |
Experimentally induced heterotopic ossification in rats influenced by anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Bone Matrix; Calcium Radioisotopes; Flurbiprofen; Ib | 1983 |
Flurbiprofen interaction with single doses of atenolol and propranolol.
Topics: Adult; Aldosterone; Atenolol; Blood Pressure; Body Weight; Female; Flurbiprofen; Heart Rate; Humans; | 1984 |
Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy.
Topics: Adenocarcinoma; Animals; Biological Availability; Body Weight; Drug Therapy, Combination; Female; Fl | 1982 |
Effect of oral multiple-dose administration of anti-inflammatory flurbiprofen chimera drug on gastric lesion, other toxicities and disposition kinetics.
Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Blood Cell Count; B | 1995 |
The effects of evening primrose oil on nerve function and capillarization in streptozotocin-diabetic rats: modulation by the cyclo-oxygenase inhibitor flurbiprofen.
Topics: Action Potentials; Animals; Body Weight; Capillaries; Cyclooxygenase Inhibitors; Diabetes Mellitus, | 1993 |
Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats.
Topics: Acetanilides; Aldehyde Reductase; Analysis of Variance; Animals; Arginine; Blood Glucose; Body Weigh | 1996 |
Anti-inflammatory effect of flurbiprofen tape applied percutaneously to rats with adjuvant-induced arthritis.
Topics: Administration, Topical; Animals; Arthritis, Experimental; Body Weight; Flurbiprofen; Male; Rats; Ra | 1995 |
Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat.
Topics: Animals; Body Temperature Regulation; Body Weight; Cachexia; Feeding Behavior; Flurbiprofen; Indomet | 1997 |
Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Cross-Linkin | 1997 |
R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.
Topics: Adenoma; Adenomatous Polyposis Coli; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-St | 1997 |
E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse.
Topics: Adenocarcinoma; Animals; Body Weight; Dietary Fats; Disease Models, Animal; Disease Progression; Flu | 2000 |
Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Casp | 2000 |
Effect of flurbiprofen on hind-limb suspension-induced bone loss.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Bone Density; Bone Resorption; Flurbi | 2001 |
Effect of flurbiprofen and 16,16-dimethyl prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats: glandular epithelium of stomach and duodenum.
Topics: 16,16-Dimethylprostaglandin E2; Adenocarcinoma; Animals; Body Weight; Duodenal Neoplasms; Female; Fl | 1990 |
Flurbiprofen enhances growth and cancellous and cortical bone accumulation in rapidly growing long bones.
Topics: Animals; Body Weight; Cell Count; Dose-Response Relationship, Drug; Flurbiprofen; Histological Techn | 1989 |
Effect of flurbiprofen and 16,16-dimethyl-prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. I. Squamous epithelium and mesenchymal tissue.
Topics: Animals; Body Weight; Carcinoma, Squamous Cell; Female; Flurbiprofen; Gastric Acid; Gastrointestinal | 1987 |