flurbiprofen has been researched along with Asthma in 15 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the contribution of the mast cell products, histamine and prostaglandins, to the bronchoconstriction induced by isocapnic hyperventilation (ISH) using single doses of terfenadine, a specific histamine H1-receptor antagonist, and flurbiprofen, a potent cyclooxygenase inhibitor." | 9.07 | The relative contributions of histamine and prostanoids to bronchoconstriction provoked by isocapnic hyperventilation in asthma. ( Finnerty, JP; Harvey, A; Holgate, ST, 1992) |
| "Bradykinin, a nonapeptide cleavage product of high molecular weight kininogen, is a potent bronchoconstrictor agonist in asthma; however, its mechanism of action is not known." | 9.06 | Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma. ( Holgate, ST; Lai, CK; Phillips, GD; Polosa, R, 1990) |
| "Bradykinin is a naturally occurring nonapeptide which may contribute to the pathogenesis of bronchial asthma." | 9.06 | The influence of cyclooxygenase inhibition on the loss of bronchoconstrictor response to repeated bradykinin challenge in asthma. ( Holgate, ST; Lai, CK; Polosa, R; Robinson, C, 1990) |
| "Inhaled adenosine and adenosine 5'-monophosphate (AMP) cause bronchoconstriction in atopic and nonatopic asthmatics by a mechanism believed to involve histamine release from airway mast cells and an interaction with neural reflexes." | 9.06 | The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma. ( Holgate, ST; Phillips, GD, 1989) |
| " We describe a 42-year-old patient with mild asthma who had a near-fatal attack of bronchospasm and required intermittent positive pressure ventilation and resuscitation following ingestion of a single tablet of flurbiprofen (Froben; Boots)." | 7.66 | Near-fatal bronchospasm in an asthmatic patient following ingestion of flurbiprofen. A case report. ( Bateman, ED; Cohen, RD; Potgieter, PD, 1982) |
| "Terfenadine or placebo was administered 3 h prior to exercise, and flurbiprofen or placebo was administered 2 h prior to exercise, in a double-blind randomized trial." | 6.67 | Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. ( Finnerty, JP; Holgate, ST, 1990) |
| "Flurbiprofen (Ansaid) is a newly released nonsteroidal antiinflammatory drug (NSAID) that is a potent inhibitor of prostaglandin synthesis." | 5.28 | Flurbiprofen (Ansaid) cross-sensitivity in an aspirin-sensitive asthmatic patient. ( Bosso, JV; Creighton, D; Stevenson, DD, 1992) |
| " We investigated the contribution of the mast cell products, histamine and prostaglandins, to the bronchoconstriction induced by isocapnic hyperventilation (ISH) using single doses of terfenadine, a specific histamine H1-receptor antagonist, and flurbiprofen, a potent cyclooxygenase inhibitor." | 5.07 | The relative contributions of histamine and prostanoids to bronchoconstriction provoked by isocapnic hyperventilation in asthma. ( Finnerty, JP; Harvey, A; Holgate, ST, 1992) |
| "Bradykinin, a nonapeptide cleavage product of high molecular weight kininogen, is a potent bronchoconstrictor agonist in asthma; however, its mechanism of action is not known." | 5.06 | Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma. ( Holgate, ST; Lai, CK; Phillips, GD; Polosa, R, 1990) |
| "Bradykinin is a naturally occurring nonapeptide which may contribute to the pathogenesis of bronchial asthma." | 5.06 | The influence of cyclooxygenase inhibition on the loss of bronchoconstrictor response to repeated bradykinin challenge in asthma. ( Holgate, ST; Lai, CK; Polosa, R; Robinson, C, 1990) |
| "Inhaled adenosine and adenosine 5'-monophosphate (AMP) cause bronchoconstriction in atopic and nonatopic asthmatics by a mechanism believed to involve histamine release from airway mast cells and an interaction with neural reflexes." | 5.06 | The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma. ( Holgate, ST; Phillips, GD, 1989) |
| "The effect of flurbiprofen, a potent cyclo-oxygenase inhibitor, on histamine and methacholine reactivity was assessed in seven atopic subjects with asthma." | 5.06 | Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man. ( Curzen, N; Holgate, ST; Rafferty, P, 1987) |
| " We describe a 42-year-old patient with mild asthma who had a near-fatal attack of bronchospasm and required intermittent positive pressure ventilation and resuscitation following ingestion of a single tablet of flurbiprofen (Froben; Boots)." | 3.66 | Near-fatal bronchospasm in an asthmatic patient following ingestion of flurbiprofen. A case report. ( Bateman, ED; Cohen, RD; Potgieter, PD, 1982) |
| "Terfenadine or placebo was administered 3 h prior to exercise, and flurbiprofen or placebo was administered 2 h prior to exercise, in a double-blind randomized trial." | 2.67 | Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. ( Finnerty, JP; Holgate, ST, 1990) |
| " This was conducted, first as a dose-response study and, second, as a time-course study." | 2.66 | Inhibition of hypertonic saline-induced bronchoconstriction by terfenadine and flurbiprofen. Evidence for the predominant role of histamine. ( Finnerty, JP; Holgate, ST; Wilmot, C, 1989) |
| "Flurbiprofen (Ansaid) is a newly released nonsteroidal antiinflammatory drug (NSAID) that is a potent inhibitor of prostaglandin synthesis." | 1.28 | Flurbiprofen (Ansaid) cross-sensitivity in an aspirin-sensitive asthmatic patient. ( Bosso, JV; Creighton, D; Stevenson, DD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 10 (66.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen, RD | 1 |
| Bateman, ED | 1 |
| Potgieter, PD | 1 |
| Polosa, R | 3 |
| Rajakulasingam, K | 1 |
| Prosperini, G | 1 |
| Magrì, S | 1 |
| Mastruzzo, C | 1 |
| Holgate, ST | 9 |
| O'Connor, BJ | 1 |
| Barnes, PJ | 1 |
| Chung, KF | 1 |
| Suman, OE | 1 |
| Morrow, JD | 1 |
| O'Malley, KA | 1 |
| Beck, KC | 1 |
| McCaig, DJ | 1 |
| Aitken, S | 1 |
| De Jonckheere, B | 1 |
| Bosso, JV | 1 |
| Creighton, D | 1 |
| Stevenson, DD | 1 |
| Finnerty, JP | 3 |
| Harvey, A | 1 |
| Hamid, M | 1 |
| Rafferty, P | 2 |
| Phillips, GD | 2 |
| Lai, CK | 2 |
| Robinson, C | 1 |
| Stevens, WH | 1 |
| Manning, PJ | 1 |
| Watson, RM | 1 |
| O'Byrne, PM | 1 |
| Wilmot, C | 1 |
| Curzen, N | 1 |
11 trials available for flurbiprofen and Asthma
| Article | Year |
|---|---|
Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aerosols; Asthma; Bronchial Hyperreactivity | 1995 |
Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cyclooxygenase Inhibitors; Double-Blind Method; Drug The | 1994 |
The relative contributions of histamine and prostanoids to bronchoconstriction provoked by isocapnic hyperventilation in asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Fe | 1992 |
The inhibitory effect of terfenadine and flurbiprofen on early and late-phase bronchoconstriction following allergen challenge in atopic asthma.
Topics: Adolescent; Adult; Allergens; Asthma; Benzhydryl Compounds; Bronchial Provocation Tests; Female; Flu | 1990 |
Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Benzhydryl Compounds; Double-Blind Method; Exercise Test; F | 1990 |
Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma.
Topics: Adult; Asthma; Benzhydryl Compounds; Bradykinin; Bronchial Provocation Tests; Female; Flurbiprofen; | 1990 |
The influence of cyclooxygenase inhibition on the loss of bronchoconstrictor response to repeated bradykinin challenge in asthma.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bradykinin; Bronchial Provocation Tests; Bronchoconstr | 1990 |
Tachyphylaxis to inhaled methacholine in normal but not asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchodilator Agents; Female; Flurbiprofen; Forced Expir | 1990 |
The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Administration, Oral; Asthma; Benzhydryl Compou | 1989 |
Inhibition of hypertonic saline-induced bronchoconstriction by terfenadine and flurbiprofen. Evidence for the predominant role of histamine.
Topics: Adult; Asthma; Benzhydryl Compounds; Bronchi; Bronchial Provocation Tests; Dose-Response Relationshi | 1989 |
Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man.
Topics: Adult; Allergens; Asthma; Benzhydryl Compounds; Bronchi; Bronchial Provocation Tests; Drug Combinati | 1987 |
4 other studies available for flurbiprofen and Asthma
| Article | Year |
|---|---|
Near-fatal bronchospasm in an asthmatic patient following ingestion of flurbiprofen. A case report.
Topics: Adult; Asthma; Bronchial Spasm; Female; Flurbiprofen; Humans; Propionates | 1982 |
Airway function after cyclooxygenase inhibition during hyperpnea-induced bronchoconstriction in guinea pigs.
Topics: Airway Resistance; Animals; Arachidonic Acid; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrict | 2000 |
Comparison of the effects of cromakalim in trachea isolated from normal and albumin-sensitive guinea-pigs.
Topics: Acetylcholine; Albumins; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Disease Mo | 1992 |
Flurbiprofen (Ansaid) cross-sensitivity in an aspirin-sensitive asthmatic patient.
Topics: Aspirin; Asthma; Drug Hypersensitivity; Flurbiprofen; Humans; Male; Middle Aged | 1992 |