flurbiprofen has been researched along with Amyloid Deposits in 7 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Similarly, amyloid plaque burden, microglia activation and aberrant cell cycle events were significantly affected by CHF5074, but not DAPT, treatment." | 1.39 | Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. ( Baldassarro, VA; Baroc, MF; Calzà, L; Fernandez, M; Ferraro, L; Giardino, L; Giuliani, A; Gusciglio, M; Imbimbo, BP; Lorenzini, L; Mangano, C; Ottonello, S; Pietrini, V; Sivilia, S; Villetti, G; Viscomi, AR, 2013) |
| "Ibuprofen treatment significantly reduced microglia area in cortex and hippocampus but not beta-amyloid burden." | 1.35 | CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease. ( Cenacchi, V; Facchinetti, F; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Villetti, G; Volta, R; Windisch, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sivilia, S | 2 |
| Lorenzini, L | 2 |
| Giuliani, A | 2 |
| Gusciglio, M | 1 |
| Fernandez, M | 1 |
| Baldassarro, VA | 1 |
| Mangano, C | 1 |
| Ferraro, L | 1 |
| Pietrini, V | 1 |
| Baroc, MF | 1 |
| Viscomi, AR | 2 |
| Ottonello, S | 2 |
| Villetti, G | 3 |
| Imbimbo, BP | 3 |
| Calzà, L | 2 |
| Giardino, L | 2 |
| Hutter-Paier, B | 1 |
| Facchinetti, F | 1 |
| Cenacchi, V | 1 |
| Volta, R | 1 |
| Lanzillotta, A | 2 |
| Pizzi, M | 2 |
| Windisch, M | 1 |
| Balducci, C | 1 |
| Mehdawy, B | 1 |
| Mare, L | 1 |
| Sarnico, I | 1 |
| Usiello, A | 1 |
| Nisticò, G | 1 |
| Forloni, G | 1 |
| Nisticò, R | 1 |
| Wilcock, DM | 2 |
| Munireddy, SK | 1 |
| Rosenthal, A | 1 |
| Ugen, KE | 1 |
| Gordon, MN | 2 |
| Morgan, D | 2 |
| Jantzen, PT | 1 |
| Li, Q | 1 |
| Kukar, T | 1 |
| Prescott, S | 1 |
| Eriksen, JL | 1 |
| Holloway, V | 1 |
| Murphy, MP | 1 |
| Koo, EH | 1 |
| Golde, TE | 1 |
| Nicolle, MM | 1 |
| Aisen, PS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Placebo-Controlled, Ascending Single-Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of CHF 5074 in Healthy Young Male Subjects[NCT00954252] | Phase 1 | 84 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for flurbiprofen and Amyloid Deposits
| Article | Year |
|---|---|
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2013 |
CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2009 |
The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
Topics: Amyloid Precursor Protein Secretases; Animals; Cricetinae; Cyclopropanes; Female; Flurbiprofen; Hipp | 2011 |
Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antibodies; Brain; Dexa | 2004 |
Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory | 2007 |
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cyclooxyge | 2007 |
Tarenflurbil: a shot on goal.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflam | 2008 |