flurazepam and Sleep Initiation and Maintenance Disorders studies

Flurazepam: A benzodiazepine derivative used mainly as a hypnotic.
flurazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.

Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.

Research Excerpts

Excerpt	Relevance	Reference
"This article contains the sleep results of the efficacy study of flurazepam 30 mg and 15 mg, midazolam 15 mg, and placebo in the 99 chronic insomniacs studied as part of this multicenter study."	9.06	Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Ancoli-Israel, S; Hauri, P; Kripke, DF; Roth, T, 1990)
"Four skills performance (psychomotor) tasks, including simple and choice reaction time, divided attention, and vigilance, were given to 99 chronic insomniacs to determine whether the use of midazolam 15 mg, or of flurazepam 15 or 30 mg, compared with placebo would produce next-day impairment throughout a 14-day treatment period."	9.06	Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Linnoila, M; Moskowitz, H; Roehrs, T, 1990)
"Methods are described for a five-center study of flurazepam and midazolam, in which 107 patients with histories of benzodiazepine use for chronic insomnia were enrolled."	9.06	Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. ( Chernik, DA; Johnson, LC; Kanitra, L, 1990)
"The 99 chronic insomniacs examined in the present multicenter study were given three cognitive tasks (reading comprehension, addition, and digit symbol substitution test [DSST]) as well as the Hopkins Symptom Checklist (HSCL) and the Profile of Mood States (POMS) in order to evaluate the effects of flurazepam (Dalmane) 15 and 30 mg, midazolam 15 mg, and placebo on cognitive performance and mood."	9.06	Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. ( Ellinwood, E; Judd, LL; McAdams, LA, 1990)
"Hypnotic efficacy and safety of 3 weeks of daily doses of 2 mg lorazepam or 30 mg flurazepam were compared in a double-blind cross-over study in eight chronic insomniacs between the ages of 29 and 60 years."	9.06	Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. ( Chang, H; McClure, DJ; Olah, A; Pecknold, JC; Walsh, J; Wilson, R, 1988)
" Oxazepam and flurazepam were effective in improving some polysomnographically defined measures of nocturnal sleep in 14 patients with chronic insomnia; flurazepam produced substantial daytime sleepiness and oxazepam did not."	9.05	Nighttime and daytime efficacy of flurazepam and oxazepam in chronic insomnia. ( Bliwise, D; Dement, W; Greenblatt, DJ; Seidel, W, 1984)
" No marked adverse reactions were found in any area for any group."	6.67	Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. ( Hauri, P; Kripke, D; Roehrs, T; Sateia, MJ, 1990)
"One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37."	6.67	Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. ( Judd, LL; Linnoila, M; Roehrs, T; Roth, T, 1990)
"Three groups of ten middle-aged insomniac patients were treated with placebo, flurazepam, or zopiclone for 12 consecutive days in a study designed to compare the residual daytime effects of long-acting flurazepam and short-acting zopiclone on a variety of cognitive and motor tasks."	6.66	Effects of flurazepam and zopiclone on the performance of chronic insomniac patients: a study of ethanol-drug interaction. ( Buck, L; Csima, A; Mamelak, M; Price, V; Smiley, A, 1987)
"This article contains the sleep results of the efficacy study of flurazepam 30 mg and 15 mg, midazolam 15 mg, and placebo in the 99 chronic insomniacs studied as part of this multicenter study."	5.06	Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Ancoli-Israel, S; Hauri, P; Kripke, DF; Roth, T, 1990)
"25 mg of brotizolam, 15 mg of flurazepam, and placebo on the sleep and performance of elderly subjects with chronic insomnia during a 2-week period of administration."	5.06	A comparative study on the effects of brotizolam and flurazepam on sleep and performance in the elderly. ( Buck, L; Csima, A; Mamelak, M; Price, V, 1989)
"Methods are described for a five-center study of flurazepam and midazolam, in which 107 patients with histories of benzodiazepine use for chronic insomnia were enrolled."	5.06	Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. ( Chernik, DA; Johnson, LC; Kanitra, L, 1990)
"Four skills performance (psychomotor) tasks, including simple and choice reaction time, divided attention, and vigilance, were given to 99 chronic insomniacs to determine whether the use of midazolam 15 mg, or of flurazepam 15 or 30 mg, compared with placebo would produce next-day impairment throughout a 14-day treatment period."	5.06	Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Linnoila, M; Moskowitz, H; Roehrs, T, 1990)
"The 99 chronic insomniacs examined in the present multicenter study were given three cognitive tasks (reading comprehension, addition, and digit symbol substitution test [DSST]) as well as the Hopkins Symptom Checklist (HSCL) and the Profile of Mood States (POMS) in order to evaluate the effects of flurazepam (Dalmane) 15 and 30 mg, midazolam 15 mg, and placebo on cognitive performance and mood."	5.06	Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. ( Ellinwood, E; Judd, LL; McAdams, LA, 1990)
"Hypnotic efficacy and safety of 3 weeks of daily doses of 2 mg lorazepam or 30 mg flurazepam were compared in a double-blind cross-over study in eight chronic insomniacs between the ages of 29 and 60 years."	5.06	Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. ( Chang, H; McClure, DJ; Olah, A; Pecknold, JC; Walsh, J; Wilson, R, 1988)
"The hypnotic effects of l-tryptophan (1 g), secobarbital (100 mg), and flurazepam (30 mg), relative to placebo, were evaluated in a sample of 54 outpatient chronic insomniacs with a major complaint of sleep maintenance insomnia."	5.05	Selectivity in response to L-tryptophan among insomniac subjects: a preliminary report. ( Hartmann, EL; Lindsley, JG; Mitchell, W, 1983)
" Oxazepam and flurazepam were effective in improving some polysomnographically defined measures of nocturnal sleep in 14 patients with chronic insomnia; flurazepam produced substantial daytime sleepiness and oxazepam did not."	5.05	Nighttime and daytime efficacy of flurazepam and oxazepam in chronic insomnia. ( Bliwise, D; Dement, W; Greenblatt, DJ; Seidel, W, 1984)
"Eleven patients suffering from chronic insomnia were given 30 mg flurazepam for 28 nights."	5.05	A clinical study of flurazepam. ( Garnett, D; Gillin, JC; Greenblatt, DJ; Mendelson, WB; Weingartner, H, 1982)
"Twelve volunteers with a complaint of chronic insomnia participated in a placebo-controlled, double-blind, crossover study of the effects of buspirone t."	5.05	Buspirone: an anxiolytic without sedative effect. ( Bliwise, NG; Cohen, SA; Dement, WC; Seidel, WF, 1985)
"6 mg) or flurazepam (30 mg) was given to chronic insomniac patients for 7 consecutive nights in parallel, double-blind design."	5.04	Methodology for demonstrating sustained efficacy of hypnotics: a comparative study of triazolam and flurazepam. ( Lasagna, L; Sundaresan, PR; Wardell, WM; Weintraub, M, 1979)
"A male patient with chronic insomnia experienced withdrawal symptoms when flurazepam (30 mg h."	3.66	Withdrawal symptoms after long-term treatment with therapeutic doses of flurazepam: a case report. ( Berlin, RM; Conell, LJ, 1983)
"Participants with chronic insomnia (N = 53), completed 2 baseline weeks of sleep diaries, and were randomly assigned to a treatment group for 2 more weeks."	2.71	Behavioral and hypnotic treatments for insomnia subtypes. ( Anderson, T; Betz, B; Binks, PG; Carney, CE; Fuller, KH; Hurry, MJ; Johnson, J; Lajos, LE; Tucci, JM; Waters, WF, 2003)
"In contrast to previous reports with insomniacs, both compounds made only modest improvements in sleep."	2.68	Effects of flurazepam and zolpidem on the perception of sleep in normal volunteers. ( Mendelson, WB, 1995)
"Sixty insomniac patients participated in a controlled double-blind parallel group study designed to investigate the dose-response relationship of zopiclone."	2.67	A dose-range finding study of zopiclone in insomniac patients. ( Dimitri, R; Le Morvan, P; Nair, NP; Schwartz, G; Thavundayil, JX, 1990)
"Outpatients complaining of insomnia were randomized to receive either estazolam 2 mg, flurazepam 30 mg or placebo for 7 consecutive nights."	2.67	Estazolam and flurazepam: a multicenter, placebo-controlled comparative study in outpatients with insomnia. ( Dominguez, RA; Roth, PB; Scharf, MB; Ware, JC, 1990)
"Estazolam is a new benzodiazepine hypnotic agent with an intermediate half-life of 12 to 15 hours."	2.67	Hypnotic efficacy of estazolam compared with flurazepam in outpatients with insomnia. ( Bremner, J; Cohn, JB; Ettinger, M; Wilcox, CS, 1991)
"One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37."	2.67	Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. ( Judd, LL; Linnoila, M; Roehrs, T; Roth, T, 1990)
" No marked adverse reactions were found in any area for any group."	2.67	Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. ( Hauri, P; Kripke, D; Roehrs, T; Sateia, MJ, 1990)
"Flurazepam-treated patients had a significantly more severe rating of adverse reactions than did placebo-treated patients."	2.66	Comparative efficacy of estazolam, flurazepam, and placebo in outpatients with insomnia. ( Dominguez, RA; Goldstein, BJ; Jacobson, AF; Steinbook, RM, 1986)
"Three groups of ten middle-aged insomniac patients were treated with placebo, flurazepam, or zopiclone for 12 consecutive days in a study designed to compare the residual daytime effects of long-acting flurazepam and short-acting zopiclone on a variety of cognitive and motor tasks."	2.66	Effects of flurazepam and zopiclone on the performance of chronic insomniac patients: a study of ethanol-drug interaction. ( Buck, L; Csima, A; Mamelak, M; Price, V; Smiley, A, 1987)
"Triazolam, 0."	2.66	Dose-related effects of triazolam and flurazepam on a circadian rhythm insomnia. ( Bliwise, NG; Cohen, SA; Dement, WC; Roth, T; Seidel, WF, 1986)
"Lormetazepam (1 and 2 mg) was tested against flurazepam (30 mg) and placebo in 60 patients (15 per treatment group) with initial, intermediate, or late insomnia."	2.65	Comparative study of lormetazepam and flurazepam in the treatment of insomnia. ( Melo de Paula, AJ, 1984)
"Zopiclone is a new nonbenzodiazepine hypnotic, the recommended dose of which is 7."	2.65	Effects of zopiclone as compared to flurazepam on sleep in women over 40 years of age. ( Buytaert, G; Hoffman, G; Quadens, OP, 1983)
"Triazolam (0."	2.64	Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. ( Bowen, AJ, 1978)
" The clinical implications are discussed with regard to the time of peak effectiveness of the drug, dosage recommendations and schedule, minimizing possible effects of the drug on daytime performance, and the rationale and method for using drug holidays in the treatment regimen."	2.64	Sleep laboratory studies of flurazepam: a model for evaluating hypnotic drugs. ( Bixler, EO; Kales, A; Kales, JD; Scharf, M, 1976)
"Flurazepam thus appears to be an effective hypnotic drug with the optimum dose for use in general practice being 15 mg at night."	2.64	A clinical and psychometric evaluation of flurazepam. ( Salkind, MR; Silverstone, T, 1975)
"Triazolam 0-5 mg was found to be preferred and to be superior to placebo, flurazepam and chloral hydrate in the treatment of insomnia."	2.64	Preference studies of triazolam with standard hypnotics in out-patients with insomnia. ( Fabre, LF; Harris, RT; McLendon, DM, 1976)
"Experimental sleep disturbance (model insomnia) was produced by intermittent white noise and the administration of 10 mg of methylphenidate (MPD)."	2.64	Model insomnia, noise, and methylphenidate, used for the evaluation of hypnotic drugs. ( Honda, H; Okuma, T, 1978)
" A significant dose-response curve was obtained with triazolam and flurazepam for some of the parameters."	2.64	Comparison of the hypnotic activity of triazolam, flurazepam hydrochloride, and placebo. ( Sunshine, A, 1975)
"Up to 40% of adults have insomnia, with difficulty getting to sleep, early waking, or feeling unrefreshed on waking."	2.44	Insomnia in the elderly. ( Lilly, J; Montgomery, P, 2007)
"Quazepam and flurazepam share pharmacokinetic properties that result in prevention of early-morning insomnia, daytime rebound anxiety, and withdrawal rebound insomnia."	2.38	Quazepam and flurazepam: differential pharmacokinetic and pharmacodynamic characteristics. ( Battista, D; Hilbert, JM, 1991)
"Rebound insomnia, a worsening of sleep compared with pretreatment levels, has been reported upon discontinuation of short half-life benzodiazepine hypnotics."	2.38	Rebound insomnia: a critical review. ( Gillin, JC; Johnson, LC; Spinweber, CL, 1989)
"Multiple etiologies for insomnia in the elderly have been described."	2.38	Insomnia in the elderly. ( Monane, M, 1992)
"In general, chronic insomniacs showed all degrees of daytime alertness regardless of nocturnal sleep parameters."	2.37	Issues in the diagnosis and treatment of insomnia. ( Carskadon, M; Dement, W; Seidel, W, 1984)
"Insomnia is defined and described with special attention to differentiating the subjective complaint and the laboratory assessment of objective sleep parameters."	2.36	Rational basis for the use of sleeping pills. ( Dement, WC, 1983)
"Physician visits for insomnia account for only a small proportion of office visits but offer the opportunity for identification of underlying illnesses and for the prevention of associated problems."	1.29	Management of insomnia in office-based practice. National prevalence and therapeutic patterns. ( Brunton, SA; Radecki, SE, 1993)
"We conclude that the evaluation of insomnia by nonpsychiatrists is often incomplete and that hypnotic drugs may be inappropriately prescribed by these physicians."	1.28	Diagnosis and treatment of outpatient insomnia by psychiatric and nonpsychiatric physicians. ( Bauwens, SF; Shorr, RI, 1992)
"Two noncontinuous sleep disturbances, insomnia in the elderly and transient insomnia in young and middle-aged adults, are probably the most acceptable indications for the use of benzodiazepines."	1.28	Clinical uses and advantages of low doses of benzodiazepine hypnotics. ( Vogel, G, 1992)
"Findings from a four-city study of the beneficial and adverse effects of hypnotics are reported."	1.28	The beneficial and adverse effects of hypnotics. ( Balter, MB; Uhlenhuth, EH, 1991)
"Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop."	1.27	Early morning insomnia with rapidly eliminated benzodiazepines. ( Bixler, EO; Kales, A; Kales, JD; Soldatos, CR, 1983)
"Zopiclone is a cyclopyrrolone derivative which exerts, in animal and man, an hypnotic activity comparable to that of flurazepam."	1.26	Efficacy and tolerance of zopiclone in insomniac geriatric patients. ( Deschenes, JP; Elie, R, 1982)
"Zopiclone is a new nonbenzodiazepine hypnotic, the recommended dose of which is 7."	1.26	Effects of zopiclone as compared to flurazepam on sleep in women over 40 years of age. ( Buytaert, G; Hoffman, G; Quadens, OP, 1982)
" Some loss of effectiveness was noted during long-term use of both doses of quazepam and, to a lesser extent, of flurazepam."	1.26	Quazepam and flurazepam: long-term use and extended withdrawal. ( Bixler, EO; Jacoby, J; Kales, A; Kales, JD; Soldatos, CR; Vela-Bueno, A, 1982)
"Flurazepam hydrochloride was experimented on 43 patients aged 33-83 yr with various forms of insomnia over a period of 4 to 23 days (mean 11."	1.25	[Study of the tolerability and effectiveness of a new sleep-inducing preparation]. ( Brambilla, CM; Marras, F; Taglioretti, D, 1975)

Research

Studies (138)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Auditory Awakening Threshold

Timeframe	Studies, this research(%)	All Research%
pre-1990	104 (75.36)	18.7374
1990's	31 (22.46)	18.2507
2000's	3 (2.17)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Montgomery, P	1
Lilly, J	1
Sylvestre, MP	1
Abrahamowicz, M	1
Waters, WF	1
Hurry, MJ	1
Binks, PG	1
Carney, CE	1
Lajos, LE	1
Fuller, KH	1
Betz, B	1
Johnson, J	1
Anderson, T	1
Tucci, JM	1
Fillingim, JM	1
Dement, W	4
Seidel, W	4
Carskadon, M	2
Muzet, A	1
Johnson, LC	8
Spinweber, CL	3
De Anna, M	1
Zucconi, M	1
Baruzzi, A	1
Cirignotta, F	1
Gallassi, R	1
Soverini, S	1
Carskadon, MA	1
Seidel, WF	4
Greenblatt, DJ	5
Dement, WC	6
Kales, A	10
Soldatos, CR	6
Bixler, EO	7
Kales, JD	9
Elie, R	3
Caillé, G	1
Levasseur, FA	1
Gareau, J	1
Rickels, K	1
Bliwise, D	2
Karacan, I	1
Mitler, M	1
Roth, T	8
Zorick, F	3
Conell, LJ	2
Berlin, RM	2
Finucane, TE	1
de Jonghe, F	1
Ameling, EH	1
Jonkers, F	1
Folkers, C	1
Schwarz, RV	1
Wesnes, K	1
Warburton, DM	1
Feldbaum, JS	1
Guilleminault, C	1
Lindsley, JG	2
Hartmann, EL	1
Mitchell, W	1
Quadens, OP	2
Hoffman, G	2
Buytaert, G	2
Melo de Paula, AJ	1
Hartmann, E	2
Spinweber, C	1
Swift, CG	1
Swift, MR	1
Hamley, J	1
Stevenson, IH	1
Crooks, J	1
Pearlman, T	1
Simmonds, K	1
Kramer, M	1
Schoen, LS	1
Mendelson, WB	5
Weingartner, H	1
Garnett, D	2
Gillin, JC	3
Velasco, M	1
Velasco, F	1
Cepeda, C	1
Romo, R	1
Pérez-Toledo, MA	1
Sanchez-Martinez, J	1
Landa-Palos, DM	1
Roehrs, T	5
Kaffeman, M	1
Sicklesteel, J	1
Vela-Bueno, A	2
Jacoby, J	1
Deschenes, JP	1
Halperin, JM	1
Miller, D	1
Iorio, LC	1
Schneider, H	1
Ladewig, D	1
Labrecque, G	1
Radecki, SE	1
Brunton, SA	1
Pollak, CP	1
Perlick, D	1
Linsner, JP	1
Welton, DG	1
Kesson, CM	1
Gray, JM	1
Lawson, DH	1
Wang, RI	1
Stockdale, SL	1
Hieb, E	1
Scharf, M	1
Vogel, GW	1
Barker, K	1
Gibbons, P	1
Thurmond, A	1
Pines, A	1
Rooney, JF	1
Arenillas, L	1
Salkind, MR	1
Silverstone, T	1
Wickstrom, E	1
Fabre, LF	2
McLendon, DM	1
Harris, RT	1
Rooke, KC	1
Gross, L	1
Pasigajen, V	1
Metzler, C	1
Bowen, AJ	1
Sundaresan, PR	1
Wardell, WM	1
Weintraub, M	1
Lasagna, L	1
Solomon, F	2
Medd, BH	1
Nair, NP	2
Schwartz, G	2
Okuma, T	1
Honda, H	1
Church, MW	1
Seales, DM	1
Rossiter, VS	1
Frost, JD	1
DeLucchi, MR	1
Cunningham, TA	1
Sunshine, A	1
Bussone, G	1
Boiardi, A	1
Lazzaroni, M	1
Taglioretti, D	1
Marras, F	1
Brambilla, CM	1
Bermejo, E	1
Rey-Bellet, J	1
Scharf, MB	3
Babbini, M	1
Torrielli, MV	1
Strumia, E	1
Gaiardi, M	1
Bartoletti, M	1
De Marchi, F	1
Montplaisir, J	1
Oswald, I	1
MacPhail, I	1
Ogilvie, WA	1
Purvis, CR	1
Anylan, WG	1
Gillin, C	1
Kripke, DF	3
de Wet, BS	1
Smith, JA	1
Renshaw, DC	1
Geyman, J	1
Klett, CJ	1
Vogel, G	1
Monane, M	1
Shorr, RI	1
Bauwens, SF	1
Walsh, JK	1
Mahowald, MW	1
Hilbert, JM	1
Battista, D	1
Roehrs, TA	1
Cohn, JB	1
Wilcox, CS	1
Bremner, J	1
Ettinger, M	1
Roth, PB	1
Dominguez, RA	2
Ware, JC	1
Balter, MB	1
Uhlenhuth, EH	1
Lavoie, G	1
Bourgouin, J	1
Le Morvan, P	2
Chernik, DA	4
Sateia, MJ	2
Dimitri, R	1
Thavundayil, JX	1
Ponciano, E	1
Freitas, F	1
Camara, J	1
Faria, M	1
Barreto, M	1
Hindmarch, I	1
Kanitra, L	1
Linnoila, M	4
Judd, LL	3
Hauri, P	4
Kripke, D	1
Chen, D	1
Ellinwood, E	3
Moskowitz, H	2
Ancoli-Israel, S	1
McAdams, LA	1
Marsh, G	1
Bergener, M	1
Gola, R	1
Hesse, C	1
Mamelak, M	2
Csima, A	2
Buck, L	2
Price, V	2
Sussman, N	1
Jacoby, JA	1
Beauchair, L	1
Fontaine, R	1
Lanaia, F	1
Scrofani, A	1
Biondi, R	1
Rodolico, F	1
Conway, W	1
Cohen, SA	2
Bliwise, NG	2
Goldstein, BJ	1
Jacobson, AF	1
Steinbook, RM	1
Baker, MI	1
Oleen, MA	1
McClure, DJ	1
Walsh, J	1
Chang, H	1
Olah, A	1
Wilson, R	1
Pecknold, JC	1
Smiley, A	1
Fleming, JA	1
Rungta, K	1
Isomura, T	1
McMillan, MJ	1
Miller, RR	1
Meyer, JA	1
Kurland, KZ	1
Itil, TM	1
Polvan, N	1
Egilmez, S	1
Saletu, B	1
Marasa, J	1
Tan, TL	1
Hussey, HH	1
Swanson, DA	1
Heimann, H	1
Schmocker, AM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Hydroxychloroquine Exposure in Systemic Lupus Erythematosus (SLE)[NCT03802188]		3,700 participants (Anticipated)	Observational	2018-05-09	Recruiting
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome[NCT00540254]	Phase 1/Phase 2	24 participants (Actual)	Interventional	2007-09-30	Completed
A Phase IV 3-Way Double-blind, Randomized, Crossover Study to Compare the Awakening Threshold Effects (Responsivity) of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs[NCT03312517]	Phase 4	12 participants (Actual)	Interventional	2018-04-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Subjects will be awakened during the night to auditory awakening tones. (NCT03312517)
Timeframe: 2.5 hours post-dose of each Study Drug administration

Reviews

19 reviews available for flurazepam and Sleep Initiation and Maintenance Disorders

Trials

64 trials available for flurazepam and Sleep Initiation and Maintenance Disorders

Other Studies

58 other studies available for flurazepam and Sleep Initiation and Maintenance Disorders

Intervention	decibels (db) (Mean)
Suvorexant 10mg	74.17
Suvorexant 20mg	83.75
Placebo Oral Capsule	79.17

Article	Year
Insomnia in the elderly. BMJ clinical evidence, 2007, Oct-01, Volume: 2007 Topics: Aged; Cognitive Behavioral Therapy; Flurazepam; Humans; Risk Factors; Sleep; Sleep Initiation and Ma	2007
Clinical trials of hypnotics. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Flurazepam; Half-Li	1983
Sleep laboratory studies of hypnotic drugs: efficacy and withdrawal effects. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2 Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Dose-Response Relationship, Drug; Fl	1983
Rational basis for the use of sleeping pills. Pharmacology, 1983, Volume: 27 Suppl 2 Topics: Anxiety; Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Kinetics; Sleep; Sleep Initia	1983
Issues in the diagnosis and treatment of insomnia. Psychopharmacology. Supplementum, 1984, Volume: 1 Topics: Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Psychomotor Performance; Respiration;	1984
[Insomnia and its treatment]. L'union medicale du Canada, 1977, Volume: 106, Issue:12 Topics: Amphetamines; Apnea; Behavior Therapy; Flurazepam; Habits; Humans; Hypnotics and Sedatives; Mental D	1977
The why and how of hypnotic drugs. British medical journal, 1979, May-05, Volume: 1, Issue:6172 Topics: Benzodiazepines; Female; Flurazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Sleep; Slee	1979
Management of insomnia. Annual review of medicine, 1979, Volume: 30 Topics: Antidepressive Agents, Tricyclic; Flurazepam; Humans; Hypnotics and Sedatives; Medical History Takin	1979
Pharmacology of benzodiazepine hypnotics. The Journal of clinical psychiatry, 1992, Volume: 53 Suppl Topics: Benzodiazepines; Flurazepam; Humans; Memory; Receptors, GABA-A; Sleep; Sleep Initiation and Maintena	1992
Review of triazolam data. The Journal of clinical psychiatry, 1992, Volume: 53 Suppl Topics: Age Factors; Aged; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Ph	1992
Insomnia in the elderly. The Journal of clinical psychiatry, 1992, Volume: 53 Suppl Topics: Adult; Age Factors; Aged; Aging; Benzodiazepines; Flurazepam; Humans; Middle Aged; Patient Education	1992
Quazepam and flurazepam: differential pharmacokinetic and pharmacodynamic characteristics. The Journal of clinical psychiatry, 1991, Volume: 52 Suppl Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Cricetinae; Flurazepam; Humans; Hy	1991
A review of the safety profiles of benzodiazepine hypnotics. The Journal of clinical psychiatry, 1991, Volume: 52 Suppl Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System; Flurazepam; Half-Life; Humans; H	1991
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per	1990
Rebound insomnia: a critical review. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:3 Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Sleep Stages; S	1989
Rebound insomnia and elimination half-life: assessment of individual subject response. Journal of clinical pharmacology, 1985, Volume: 25, Issue:2 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D	1985
Pharmacological effects of sedative-hypnotics, narcotic analgesics, and alcohol during sleep. The Medical clinics of North America, 1985, Volume: 69, Issue:6 Topics: Adult; Aged; Anti-Anxiety Agents; Ethanol; Female; Flurazepam; Humans; Hypnotics and Sedatives; Male	1985
Behavioral side effects of benzodiazepine hypnotics. Clinical neuropharmacology, 1985, Volume: 8 Suppl 1 Topics: Amnesia; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Flurazepam; Humans; Hypnotics and Sedatives;	1985
Drug therapy reviews. Rational use of psychotropic drugs. I. Hypnotics. The Journal of the Maine Medical Association, 1974, Volume: 65, Issue:8 Topics: Barbiturates; Chlorates; Dose-Response Relationship, Drug; Dreams; Drug Interactions; Drug Synergism	1974

Article	Year
Behavioral and hypnotic treatments for insomnia subtypes. Behavioral sleep medicine, 2003, Volume: 1, Issue:2 Topics: Adult; Behavior Therapy; Combined Modality Therapy; Electroencephalography; Electromyography; Female	2003
Double-blind evaluation of temazepam, flurazepam, and placebo in geriatric insomniacs. Clinical therapeutics, 1982, Volume: 4, Issue:5 Topics: Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Flurazepam; Humans	1982
[Double-blind comparison of lormetazepam and flurazepam in the treatment of patients with insomnia]. Il Farmaco; edizione pratica, 1982, Volume: 37, Issue:9 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blin	1982
Daytime carryover of triazolam and flurazepam in elderly insomniacs. Sleep, 1982, Volume: 5, Issue:4 Topics: Aged; Anti-Anxiety Agents; Arousal; Clinical Trials as Topic; Emotions; Female; Flurazepam; Humans;	1982
Comparative hypnotic activity of single doses of loprazolam, flurazepam, and placebo. Journal of clinical pharmacology, 1983, Volume: 23, Issue:1 Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Doub	1983
Clinical trials of hypnotics. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Flurazepam; Half-Li	1983
Flurazepam and temazepam in the treatment of insomnia in a general hospital population. Pharmacopsychiatry, 1984, Volume: 17, Issue:4 Topics: Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Flurazepam;	1984
A comparison of temazepam and flurazepam in terms of sleep quality and residual changes in performance. Neuropsychobiology, 1984, Volume: 11, Issue:4 Topics: Adult; Anti-Anxiety Agents; Attention; Cognition; Discrimination Learning; Female; Flicker Fusion; F	1984
Selectivity in response to L-tryptophan among insomniac subjects: a preliminary report. Sleep, 1983, Volume: 6, Issue:3 Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Female; Flurazepam; Humans; Hypn	1983
Effects of zopiclone as compared to flurazepam on sleep in women over 40 years of age. Pharmacology, 1983, Volume: 27 Suppl 2 Topics: Azabicyclo Compounds; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Electro	1983
Comparative study of lormetazepam and flurazepam in the treatment of insomnia. Clinical therapeutics, 1984, Volume: 6, Issue:4 Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relati	1984
Chronic insomnia: effects of tryptophan, flurazepam, secobarbital, and placebo. Psychopharmacology, 1983, Volume: 80, Issue:2 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Female; Flurazepam; Humans; Male; Placebos; Secoba	1983
Nighttime and daytime efficacy of flurazepam and oxazepam in chronic insomnia. The American journal of psychiatry, 1984, Volume: 141, Issue:2 Topics: Chronic Disease; Circadian Rhythm; Electroencephalography; Electromyography; Electrooculography; Flu	1984
A clinical study of flurazepam. Sleep, 1982, Volume: 5, Issue:4 Topics: Clinical Trials as Topic; Cognition; Drug Evaluation; Electroencephalography; Flurazepam; Humans; Ps	1982
Effect of a new thienodiazepine (We-941) on sleep patterns of normal and insomniac subjects. Neuropharmacology, 1981, Volume: 20, Issue:5 Topics: Adolescent; Adult; Azepines; Clinical Trials as Topic; Flurazepam; Humans; Hypnotics and Sedatives;	1981
A new thienodiazepine, brotizolam, for the treatment of insomnia. The Journal of international medical research, 1982, Volume: 10, Issue:2 Topics: Adult; Azepines; Chemical Phenomena; Chemistry; Double-Blind Method; Flurazepam; Humans; Middle Aged	1982
Effects of flurazepam and zolpidem on the perception of sleep in normal volunteers. Sleep, 1995, Volume: 18, Issue:2 Topics: Adult; Cognition; Female; Flurazepam; Humans; Hypnotics and Sedatives; Male; Placebos; Polysomnograp	1995
Effects of flurazepam and zolpidem on the perception of sleep in insomniacs. Sleep, 1995, Volume: 18, Issue:2 Topics: Adult; Arousal; Electroencephalography; Female; Flurazepam; Humans; Hypnotics and Sedatives; Male; P	1995
Benzodiazepine drugs in general medical patients. British medical journal, 1976, Mar-20, Volume: 1, Issue:6011 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Drug Evaluation; Drug Prescriptions; Flurazepam; Huma	1976
Hypnotic efficacy of lorazepam and flurazepam. Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:2 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Flurazepam; Humans; Lorazepam; Male; Sleep; Sleep Ini	1976
Sleep laboratory studies of flurazepam: a model for evaluating hypnotic drugs. Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:5 Pt 1 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Electroencephalography; Electromyography; Electroocul	1976
A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs. Psychopharmacology, 1976, May-05, Volume: 47, Issue:1 Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Female; Flurazepam; Humans; Male; Middle Aged;	1976
Flurazepam ('Dalmane') in the treatment of insomnia in patients with respiratory disorders. The Practitioner, 1976, Volume: 217, Issue:1298 Topics: Aged; Amobarbital; Anti-Anxiety Agents; Clinical Trials as Topic; Dreams; Flurazepam; Humans; Male;	1976
A clinical and psychometric evaluation of flurazepam. British journal of clinical pharmacology, 1975, Volume: 2, Issue:3 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Drug Evaluation; Female; Flurazepam; Humans; Male; Mo	1975
[Flunitrazepam and flurazepam. A comparative study]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Nov-30, Volume: 92, Issue:33 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Drug Evaluation; Female; Flunitrazepam; Flurazepam; Hu	1976
Preference studies of triazolam with standard hypnotics in out-patients with insomnia. The Journal of international medical research, 1976, Volume: 4, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Chloral Hydrate; Clinical Trials as Topic; Double-Blin	1976
Multiclinic double-blind comparison of triazolam and flurazepam for seven nights in outpatients with insomnia. Journal of clinical pharmacology, 1977, Volume: 17, Issue:7 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Drug Ev	1977
Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. The Journal of international medical research, 1978, Volume: 6, Issue:4 Topics: Adult; Anti-Anxiety Agents; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female;	1978
Methodology for demonstrating sustained efficacy of hypnotics: a comparative study of triazolam and flurazepam. Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:4 Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Flurazepam; Humans; Middl	1979
Model insomnia, noise, and methylphenidate, used for the evaluation of hypnotic drugs. Psychopharmacology, 1978, Apr-28, Volume: 57, Issue:2 Topics: Adult; Drug Evaluation; Electroencephalography; Flurazepam; Humans; Hypnotics and Sedatives; Male; M	1978
Insomnia in the elderly: treatment with flurazepam hydrochloride. Journal of the American Geriatrics Society, 1979, Volume: 27, Issue:12 Topics: Aged; Female; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Sleep Stages; Sleep, R	1979
Comparison of the hypnotic activity of triazolam, flurazepam hydrochloride, and placebo. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:5 Topics: Adult; Aged; Anti-Anxiety Agents; Benzazepines; Chlorobenzenes; Clinical Trials as Topic; Dose-Respo	1975
Flurazepam (Dalmane). The Medical letter on drugs and therapeutics, 1975, Mar-28, Volume: 17, Issue:7 Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Flurazepam; Half-Life; Humans; Sleep Initiation and M	1975
Effectiveness of hypnotic drugs with prolonged use: flurazepam and pentobarbital. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:3 Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Drug Evaluation; Electroencephalography; Flura	1975
Sedative-hypnotic properties of a new benzodiazepine in comparison with flurazepam. Pharmacological and clinical findings. Arzneimittel-Forschung, 1975, Volume: 25, Issue:8 Topics: Aged; Animals; Anti-Anxiety Agents; Benzodiazepinones; Blood Pressure; Cats; Clinical Trials as Topi	1975
Comparison of diazepam and flurazepam in the treatment of insomnia in general practice. The Journal of international medical research, 1979, Volume: 7, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Capsules; Clinical Trials as Topic; Diazepam; Double-	1979
A clinical study of insomnia. American family physician, 1975, Volume: 11, Issue:3 Topics: Adult; Aged; Anxiety Disorders; Clinical Trials as Topic; Depression; Doxepin; Drug Therapy, Combina	1975
Objective measurements of daytime sleepiness and performance comparing quazepam with flurazepam in two adult populations using the Multiple Sleep Latency Test. The Journal of clinical psychiatry, 1991, Volume: 52 Suppl Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Anxiety Agents; Benzodiazepines; Circa	1991
Hypnotic efficacy of estazolam compared with flurazepam in outpatients with insomnia. Journal of clinical pharmacology, 1991, Volume: 31, Issue:8 Topics: Adolescent; Adult; Aged; Ambulatory Care; Double-Blind Method; Estazolam; Female; Flurazepam; Humans	1991
Estazolam and flurazepam: a multicenter, placebo-controlled comparative study in outpatients with insomnia. Journal of clinical pharmacology, 1990, Volume: 30, Issue:5 Topics: Ambulatory Care; Anti-Anxiety Agents; Double-Blind Method; Drug Evaluation; Estazolam; Flurazepam; H	1990
Zopiclone versus flurazepam in insomnia: prolonged administration and withdrawal. International clinical psychopharmacology, 1990, Volume: 5, Issue:4 Topics: Adult; Azabicyclo Compounds; Double-Blind Method; Female; Flurazepam; Humans; Hypnotics and Sedative	1990
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per	1990
A dose-range finding study of zopiclone in insomniac patients. International clinical psychopharmacology, 1990, Volume: 5 Suppl 2 Topics: Adolescent; Adult; Aged; Arousal; Azabicyclo Compounds; Dose-Response Relationship, Drug; Double-Bli	1990
A comparison of the efficacy, tolerance and residual effects of zopiclone, flurazepam and placebo in insomniac outpatients. International clinical psychopharmacology, 1990, Volume: 5 Suppl 2 Topics: Adolescent; Adult; Arousal; Attention; Azabicyclo Compounds; Body Weight; Double-Blind Method; Drug	1990
Effects of flurazepam and midazolam on sleep and next-day performance in chronic insomniacs: report of a multicenter study. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Flurazepam; Humans; Midazolam; Sleep; Sleep Initiation and Maintenance Disorders	1990
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Affect; Arousal; Attention; Electroencephalography; Female; Flurazepam; Half-Life; Humans; Ma	1990
Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Affect; Arousal; Electroencephalography; Female; Flurazepam; Humans; Male; Midazolam; Middle	1990
Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Double-Blind Method; Female; Flurazepam; Humans; Male; Midazolam; Middle Aged; Sleep Apnea Sy	1990
A multicenter study of sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: executive summary. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Affect; Arousal; Chronic Disease; Double-Blind Method; Flurazepam; Humans; Midazolam; Psychom	1990
Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Arousal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurazepam; Humans	1990
Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Arousal; Attention; Dose-Response Relationship, Drug; Female; Flurazepam; Humans; Male; Midaz	1990
Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Affect; Arousal; Attention; Dose-Response Relationship, Drug; Drug Administration Schedule; F	1990
Plasma concentrations of flurazepam and midazolam in chronic insomniacs during 14-day use and their relationship to therapeutic effects and next-day performance and mood. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Adult; Arousal; Attention; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; F	1990
A multicenter 14-day study of flurazepam and midazolam in chronic insomniacs: general discussion and conclusions. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl Topics: Arousal; Attention; Double-Blind Method; Female; Flurazepam; Humans; Male; Midazolam; Middle Aged; P	1990
The influence of age-dependent pharmacokinetics on the pharmacodynamics of hypnotic drugs: comparison of two hypnotics with different half-lives. International psychogeriatrics, 1989,Spring, Volume: 1, Issue:1 Topics: Aged; Arousal; Azabicyclo Compounds; Double-Blind Method; Female; Flurazepam; Half-Life; Hospitaliza	1989
A comparative study on the effects of brotizolam and flurazepam on sleep and performance in the elderly. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:4 Topics: Aged; Arousal; Attention; Azepines; Clinical Trials as Topic; Discrimination Learning; Double-Blind	1989
Rebound insomnia and elimination half-life: assessment of individual subject response. Journal of clinical pharmacology, 1985, Volume: 25, Issue:2 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D	1985
Buspirone: an anxiolytic without sedative effect. Psychopharmacology, 1985, Volume: 87, Issue:3 Topics: Adult; Anti-Anxiety Agents; Buspirone; Chronic Disease; Clinical Trials as Topic; Double-Blind Metho	1985
Comparative efficacy of estazolam, flurazepam, and placebo in outpatients with insomnia. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:7 Topics: Adult; Aged; Ambulatory Care; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Dr	1986
Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. Journal of clinical pharmacology, 1988, Volume: 28, Issue:1 Topics: Adult; Arousal; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Electroencephalograp	1988
Effects of flurazepam and zopiclone on the performance of chronic insomniac patients: a study of ethanol-drug interaction. Sleep, 1987, Volume: 10 Suppl 1 Topics: Adult; Azabicyclo Compounds; Drug Interactions; Ethanol; Female; Flurazepam; Humans; Hypnotics and S	1987
Dose-related effects of triazolam and flurazepam on a circadian rhythm insomnia. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:3 Topics: Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Flurazepam; Humans;	1986
Controlled evaluation of flurazepam hydrochloride, a new nonbarbiturate hypnotic. Military medicine, 1973, Volume: 138, Issue:8 Topics: Adult; Benzazepines; Clinical Trials as Topic; Flurazepam; Humans; Hypnotics and Sedatives; Middle A	1973
A double-blind evaluation of a new hypnotic--flurazepam hydrochloride. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Aug-04, Volume: 47, Issue:30 Topics: Adult; Aged; Amobarbital; Benzazepines; Clinical Trials as Topic; Female; Flurazepam; Humans; Hypnot	1973

Article	Year
Flexible modeling of the cumulative effects of time-dependent exposures on the hazard. Statistics in medicine, 2009, Nov-30, Volume: 28, Issue:27 Topics: Accidental Falls; Cohort Studies; Dose-Response Relationship, Drug; Flurazepam; Humans; Hypnotics an	2009
Choice of benzodiazepines. The Medical letter on drugs and therapeutics, 1981, May-01, Volume: 23, Issue:9 Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Flurazepam; Half-Life; Humans; Liver	1981
Daytime alertness, insomnia, and benzodiazepines. Sleep, 1982, Volume: 5 Suppl 1 Topics: Adult; Anti-Anxiety Agents; Arousal; Benzodiazepines; Double-Blind Method; Flurazepam; Humans; Loraz	1982
Benzodiazepine hypnotics increase heart rate during sleep. Sleep, 1982, Volume: 5, Issue:3 Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Flurazepam; Heart Rate; Humans; Male; Sleep; Sleep	1982
Early morning insomnia with rapidly eliminated benzodiazepines. Science (New York, N.Y.), 1983, Apr-01, Volume: 220, Issue:4592 Topics: Anti-Anxiety Agents; Benzodiazepines; Flurazepam; Half-Life; Humans; Midazolam; Sleep; Sleep Initiat	1983
Daytime sleepiness as a criterion in hypnotic medication trials: comparison of triazolam and flurazepam. Sleep, 1983, Volume: 6, Issue:2 Topics: Adult; Anti-Anxiety Agents; Arousal; Double-Blind Method; Female; Flurazepam; Humans; Male; Sleep In	1983
Withdrawal after substitution of a short-acting for a long-acting benzodiazepine. JAMA, 1983, Nov-25, Volume: 250, Issue:20 Topics: Anti-Anxiety Agents; Anxiety; Chronic Disease; Delayed-Action Preparations; Diazepam; Flurazepam; Ha	1983
Flurazepam and other benzodiazepines. Annals of internal medicine, 1984, Volume: 101, Issue:3 Topics: Anti-Anxiety Agents; Drug Utilization; Flurazepam; Humans; Sleep Initiation and Maintenance Disorder	1984
Inadvertent benzodiazepine withdrawal. American family physician, 1984, Volume: 30, Issue:4 Topics: Anti-Anxiety Agents; Flurazepam; Humans; Male; Middle Aged; Sleep Initiation and Maintenance Disorde	1984
Sleep spindle and delta changes during chronic use of a short-acting and a long-acting benzodiazepine hypnotic. Electroencephalography and clinical neurophysiology, 1983, Volume: 55, Issue:6 Topics: Adult; Anti-Anxiety Agents; Brain; Double-Blind Method; Electroencephalography; Female; Flurazepam;	1983
[Benzodiazepines: effects on sleep and on attention capacity the following day. Long-term study administration of lormetazepam and flurazepam]. La Clinica terapeutica, 1984, May-15, Volume: 109, Issue:3 Topics: Adult; Anti-Anxiety Agents; Attention; Benzodiazepines; Female; Flurazepam; Humans; Lorazepam; Male;	1984
Side-effect 'tolerance' in elderly long-term recipients of benzodiazepine hypnotics. Age and ageing, 1984, Volume: 13, Issue:6 Topics: Aged; Biotransformation; Dose-Response Relationship, Drug; Drug Tolerance; Female; Flurazepam; Human	1984
Withdrawal symptoms after long-term treatment with flurazepam. The American journal of psychiatry, 1984, Volume: 141, Issue:1 Topics: Anxiety Disorders; Depressive Disorder; Diazepam; Flurazepam; Humans; Sleep Initiation and Maintenan	1984
A good night's sleep may be in store for patients with COPD. Archives of internal medicine, 1984, Volume: 144, Issue:1 Topics: Flurazepam; Humans; Lung Diseases, Obstructive; Male; Sleep Initiation and Maintenance Disorders	1984
Problems in the use of long-acting hypnotics in older patients. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:4 Topics: Age Factors; Aged; Ataxia; Flurazepam; Hospitalization; Humans; Motor Skills; Sleep Initiation and M	1984
Withdrawal symptoms after long-term treatment with therapeutic doses of flurazepam: a case report. The American journal of psychiatry, 1983, Volume: 140, Issue:4 Topics: Adult; Chronic Disease; Flurazepam; Humans; Male; Sleep Initiation and Maintenance Disorders; Substa	1983
Flurazepam for short-term treatment of complaints of insomnia. Journal of clinical pharmacology, 1982, Volume: 22, Issue:7 Topics: Adult; Female; Flurazepam; Humans; Male; Sleep Initiation and Maintenance Disorders; Sleep Stages	1982
Quazepam and flurazepam: long-term use and extended withdrawal. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:6 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Drug Evaluation; Flurazepam; Half-Life; Humans; Middle	1982
Effects of zopiclone as compared to flurazepam on sleep in women over 40 years of age. International pharmacopsychiatry, 1982, Volume: 17 Suppl 2 Topics: Azabicyclo Compounds; Double-Blind Method; Drug Evaluation; Electroencephalography; Female; Flurazep	1982
Efficacy and tolerance of zopiclone in insomniac geriatric patients. International pharmacopsychiatry, 1982, Volume: 17 Suppl 2 Topics: Aged; Azabicyclo Compounds; Double-Blind Method; Drug Evaluation; Female; Flurazepam; Humans; Hypnot	1982
Sleep-inducing effects of three hypnotics in a new model of insomnia in rats. Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:6 Topics: Animals; Disease Models, Animal; Electroencephalography; Electromyography; Flurazepam; Humans; Hypno	1981
Flurazepam-induced sleep apnea syndrome in a patient with insomnia and mild sleep-related respiratory changes. The Journal of nervous and mental disease, 1981, Volume: 169, Issue:4 Topics: Adult; Flurazepam; Humans; Male; Placebos; Sleep Apnea Syndromes; Sleep Initiation and Maintenance D	1981
[Dalmadorm, an almost ideal hypnotic]. Die Medizinische Welt, 1980, Jan-11, Volume: 31, Issue:2 Topics: Drug Evaluation; Drug Interactions; Flurazepam; Humans; Hypnotics and Sedatives; Sleep Initiation an	1980
[Does a rebound insomnia following benzodiazepine administration exist?]. Deutsche medizinische Wochenschrift (1946), 1980, Oct-24, Volume: 105, Issue:43 Topics: Benzodiazepines; Diazepam; Flunitrazepam; Flurazepam; Humans; Nitrazepam; Sleep Initiation and Maint	1980
[Between the two...]. L'union medicale du Canada, 1980, Volume: 109, Issue:10 Topics: Aged; Flurazepam; Humans; Hypnotics and Sedatives; Sleep; Sleep Initiation and Maintenance Disorders	1980
Management of insomnia in office-based practice. National prevalence and therapeutic patterns. Archives of family medicine, 1993, Volume: 2, Issue:11 Topics: Adolescent; Adult; Aged; Data Collection; Female; Flurazepam; Humans; Male; Medicine; Middle Aged; P	1993
Sleep and motor activity of community elderly who frequently use bedtime medications. Biological psychiatry, 1994, Jan-01, Volume: 35, Issue:1 Topics: Aged; Circadian Rhythm; Diazepam; Drug Administration Schedule; Female; Flurazepam; Humans; Hypnotic	1994
When "my heart stood still". North Carolina medical journal, 1993, Volume: 54, Issue:10 Topics: Arrhythmias, Cardiac; Diuretics; Flurazepam; Heart Arrest; Humans; Pacemaker, Artificial; Sleep Init	1993
The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. The Journal of international medical research, 1976, Volume: 4, Issue:5 Topics: Adult; Aged; Anti-Anxiety Agents; Barbiturates; Diphenhydramine; Drug Combinations; Family Practice;	1976
[Drugs against insomnia]. Der Internist, 1978, Volume: 19, Issue:9 Topics: Barbiturates; Chloral Hydrate; Diphenhydramine; Flurazepam; Glutethimide; Humans; Hypnotics and Seda	1978
Sleeping pills. The New England journal of medicine, 1979, Jul-26, Volume: 301, Issue:4 Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders	1979
Sleeping pills and insomnia. Science (New York, N.Y.), 1979, Jul-06, Volume: 205, Issue:4401 Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Substance-Relat	1979
[Comparison of the hypnotic activity of triazolam and flurazepam]. L'union medicale du Canada, 1979, Volume: 108, Issue:2 Topics: Adult; Anti-Anxiety Agents; Evaluation Studies as Topic; Female; Flurazepam; Humans; Male; Middle Ag	1979
Auditory arousal thresholds of good sleepers and poor sleepers with and without flurazepam. Sleep, 1979,Spring, Volume: 1, Issue:3 Topics: Acoustic Stimulation; Adult; Arousal; Auditory Threshold; Double-Blind Method; Flurazepam; Humans; M	1979
Letter: Use of hypnotics. The New England journal of medicine, 1975, Jan-23, Volume: 292, Issue:4 Topics: Animals; Anti-Anxiety Agents; Flurazepam; Humans; Hypnotics and Sedatives; Sleep Initiation and Main	1975
Letter: Adverse reaction to flurazepam. Canadian Medical Association journal, 1975, Apr-05, Volume: 112, Issue:7 Topics: Aged; Anti-Anxiety Agents; Flurazepam; Humans; Male; Psychoses, Substance-Induced; Sleep Initiation	1975
[Controlled clinical trial of a new benzodiazepine (Ro 5-6901) active on sleep disorders]. La Clinica terapeutica, 1975, Jun-30, Volume: 73, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Drug Evaluation; Female; Flurazepam; Humans; Middle Ag	1975
[Study of the tolerability and effectiveness of a new sleep-inducing preparation]. Minerva medica, 1975, Sep-08, Volume: 66, Issue:58 Topics: Adult; Aged; Anti-Anxiety Agents; Female; Flurazepam; Humans; Male; Middle Aged; Sleep Initiation an	1975
[Comparative study on the hypnotic effect of flurazepam and heptabarbital]. Revue medicale de la Suisse romande, 1975, Volume: 95, Issue:8 Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Barbiturates; Flurazepam; Humans; Mental Disorders; M	1975
Sleeping pills and insomnia. Science (New York, N.Y.), 1979, Jul-06, Volume: 205, Issue:4401 Topics: Flurazepam; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders	1979
Sleeping pills and insomnia. Science (New York, N.Y.), 1979, Jul-06, Volume: 205, Issue:4401 Topics: Flurazepam; Humans; Hypnotics and Sedatives; Risk; Sleep Initiation and Maintenance Disorders	1979
Which benzodiazepine, why and how? South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Sep-01, Volume: 56, Issue:12 Topics: Flurazepam; Humans; Nitrazepam; Sleep; Sleep Initiation and Maintenance Disorders	1979
Editorial: Evaluation and management of insomnia. Connecticut medicine, 1975, Volume: 39, Issue:2 Topics: Flurazepam; Humans; Sleep Initiation and Maintenance Disorders	1975
Clinical uses and advantages of low doses of benzodiazepine hypnotics. The Journal of clinical psychiatry, 1992, Volume: 53 Suppl Topics: Adult; Aged; Amnesia; Benzodiazepines; Dose-Response Relationship, Drug; Drug Administration Schedul	1992
Diagnosis and treatment of outpatient insomnia by psychiatric and nonpsychiatric physicians. The American journal of medicine, 1992, Volume: 93, Issue:1 Topics: Disease; Drug Prescriptions; Drug Utilization; Female; Flurazepam; General Surgery; Humans; Internal	1992
Avoiding the blanket approach to insomnia. Targeted therapy for specific causes. Postgraduate medicine, 1991, Volume: 90, Issue:1 Topics: Anti-Anxiety Agents; Benzodiazepines; Chronic Disease; Diagnosis, Differential; Estazolam; Flurazepa	1991
The beneficial and adverse effects of hypnotics. The Journal of clinical psychiatry, 1991, Volume: 52 Suppl Topics: Adolescent; Adult; Aged; Attitude to Health; Benzodiazepines; Data Collection; Drug Prescriptions; E	1991
Putting benzodiazepine hypnotics into proper therapeutic perspective. The Journal of the Medical Society of New Jersey, 1985, Volume: 82, Issue:3 Topics: Anti-Anxiety Agents; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Temazepam; Tria	1985
Benzodiazepines: half-life and daytime sleepiness. The American journal of psychiatry, 1985, Volume: 142, Issue:6 Topics: Anti-Anxiety Agents; Circadian Rhythm; Flurazepam; Half-Life; Humans; Oxazepam; Sleep; Sleep Initiat	1985
[Efficacy and tolerance of triazolam compared with flurazepam in patients with insomnia]. La Clinica terapeutica, 1985, Apr-15, Volume: 113, Issue:1 Topics: Adolescent; Adult; Anti-Anxiety Agents; Drug Tolerance; Female; Flurazepam; Humans; Male; Middle Age	1985
The use of benzodiazepine hypnotics in the elderly. Pharmacotherapy, 1988, Volume: 8, Issue:4 Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Canada; Drug Interactions; Drug Prescriptions; Dru	1988
Withdrawal regimen for triazolam-dependent patients. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1986, Jun-01, Volume: 134, Issue:11 Topics: Diazepam; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndr	1986
Quazepam: sleep laboratory studies of effectiveness and withdrawal. Clinical neuropharmacology, 1985, Volume: 8 Suppl 1 Topics: Anti-Anxiety Agents; Benzodiazepines; Flurazepam; Humans; Sleep Initiation and Maintenance Disorders	1985
Anxiolytic effects of a new triazolobenzodiazepine, U-31,889. Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:9 Topics: Adult; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Blood Circulation; Central Nervous Sys	1973
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence. JAMA, 1974, Feb-04, Volume: 227, Issue:5 Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi	1974
Editorial: Insomnia. JAMA, 1974, Feb-04, Volume: 227, Issue:5 Topics: Apnea; Chronic Disease; Flurazepam; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Male; Middl	1974
[Sleep disorders, their origin and treatment]. Revue medicale de la Suisse romande, 1974, Volume: 94, Issue:7 Topics: Age Factors; Antidepressive Agents; Depression; Flurazepam; Humans; Intracranial Arteriosclerosis; M	1974
Two more benzodiazepines: clorazepate and flurazepam. Drug and therapeutics bulletin, 1974, Apr-26, Volume: 12, Issue:9 Topics: Anti-Anxiety Agents; Benzazepines; Carboxylic Acids; Clorazepate Dipotassium; Electroencephalography	1974