flurazepam has been researched along with Seizures in 25 studies
Flurazepam: A benzodiazepine derivative used mainly as a hypnotic.
flurazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 7.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| " In vivo tolerance was measured by a reduced ability of the alpha(1)-subunit-selective agonist zolpidem to suppress pentylenetetrazole-induced seizures." | 3.70 | Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance. ( Chen, S; Kometiani, P; Lilly, SM; Rosenberg, HC; Tietz, EI; Zeng, XJ, 1999) |
| "Cold water swim stress has been shown to decrease the ability of flurazepam, a prototypic GABA-positive benzodiazepine, to antagonize the electrical precipitation of seizures in mice." | 3.68 | Paradoxical effect of flurazepam. ( Deutsch, SI; Mastropaolo, J; Norris, DO; O'Connor, DA, 1992) |
| "Twenty-four hours after mice were forced to swim for up to 10 min in cold (6 degrees C) water, the ability of flurazepam to antagonize the electrical precipitation of seizures was reduced." | 3.68 | Reduction of flurazepam's antiseizure efficacy persists after stress. ( Deutsch, SI; Lukacs, LG; Mastropaolo, J; Norris, DO; O'Connor, DA; Park, CH, 1992) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 3.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| " Determination of the anticonvulsant effects of flurazepam (1-6 mg/kg) against seizures induced by 3-mercaptopropionic acid revealed that the SS line was more sensitive to the anticonvulsant effects of this benzodiazepine." | 3.67 | Differential response to flurazepam in long-sleep and short-sleep mice. ( Freund, RK; Marley, RJ; Wehner, JM, 1988) |
| "The latency to onset of clonic seizure and the PTZ threshold were recorded." | 1.36 | [Drugs and the mechanism for reversing the tolerance of flurazepan in rats]. ( Bian, FZ; Wang, L; Wang, YH; Wang, YX, 2010) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| "At higher doses, however, convulsions again emerged." | 1.26 | Central excitatory actions of flurazepam. ( Rosenberg, HC, 1980) |
| "Comparison of the PD50 from clonic seizure at the peak-effect hours revealed that the benzodiazepines were 16 to 96 times more potent than phenobarbitone on a molar basis, while phenobarbitone itself was 12 to 26 times more potent than ethosuximide and trimethadione." | 1.26 | The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats. ( Banerjee, U; Yeoh, PN, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (60.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bian, FZ | 1 |
| Wang, L | 1 |
| Wang, YX | 1 |
| Wang, YH | 1 |
| Rosenberg, HC | 3 |
| Cowen, PJ | 1 |
| Green, AR | 1 |
| Nutt, DJ | 4 |
| Bichard, AR | 2 |
| Little, HJ | 6 |
| McIntyre, DC | 1 |
| Pusztay, W | 1 |
| Edson, N | 1 |
| Reigel, CE | 2 |
| Bourn, WM | 2 |
| Deutsch, SI | 4 |
| Rosse, RB | 2 |
| Steinberg, K | 1 |
| Morn, C | 1 |
| Koetzner, L | 1 |
| Riggs, R | 1 |
| Mastropaolo, J | 4 |
| Tietz, EI | 2 |
| Zeng, XJ | 1 |
| Chen, S | 1 |
| Lilly, SM | 1 |
| Kometiani, P | 1 |
| Banerjee, U | 1 |
| Yeoh, PN | 1 |
| Norris, DO | 2 |
| O'Connor, DA | 2 |
| Park, CH | 1 |
| Lukacs, LG | 1 |
| Pertwee, RG | 1 |
| Browne, SE | 1 |
| Ross, TM | 1 |
| Stretton, CD | 1 |
| Dolin, SJ | 2 |
| Patch, TL | 2 |
| Rabbani, M | 2 |
| Taberner, PV | 1 |
| Siarey, RJ | 1 |
| Bowhay, AR | 1 |
| Huntzinger, JA | 1 |
| Novitzki, MR | 1 |
| Zhang, H | 1 |
| Taylor, SC | 2 |
| Standing, BL | 1 |
| Gale, RG | 1 |
| Little, H | 1 |
| Marley, RJ | 1 |
| Freund, RK | 1 |
| Wehner, JM | 1 |
| Hilbert, JM | 1 |
| Iorio, L | 1 |
| Moritzen, V | 1 |
| Barnett, A | 1 |
| Symchowicz, S | 1 |
| Zampaglione, N | 1 |
| Garrett, RL | 1 |
| Risinger, FO | 1 |
| Itil, TM | 1 |
| Polvan, N | 1 |
| Egilmez, S | 1 |
| Saletu, B | 1 |
| Marasa, J | 1 |
| Walser, A | 1 |
| Fryer, RI | 1 |
25 other studies available for flurazepam and Seizures
| Article | Year |
|---|---|
[Drugs and the mechanism for reversing the tolerance of flurazepan in rats].
Topics: Animals; Anticonvulsants; Drug Tolerance; Flurazepam; Hippocampus; Male; Neuropeptide Y; Pentylenete | 2010 |
Central excitatory actions of flurazepam.
Topics: Animals; Behavior, Animal; Cats; Central Nervous System Stimulants; Dose-Response Relationship, Drug | 1980 |
Ethyl beta-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats.
Topics: Animals; Bicuculline; Carbolines; Dose-Response Relationship, Drug; Flurazepam; Indoles; Rats; Recep | 1981 |
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome.
Topics: Anesthetics; Animals; Bicuculline; Body Temperature; Flurazepam; gamma-Aminobutyric Acid; Male; Mice | 1982 |
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome.
Topics: Animals; Benzodiazepinones; Bicuculline; Flumazenil; Flurazepam; Male; Mice; Nervous System Diseases | 1982 |
Effects of flurazepam on kindled amygdala convulsions in catecholamine-depleted rats.
Topics: Amygdala; Animals; Benzodiazepines; Brain Chemistry; Catecholamines; Dopamine; Dose-Response Relatio | 1982 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Spr | 1995 |
Evaluation of in vivo interactions in mice between flurazepam and two neuroactive steroids.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Electric Stimulation; Flurazepam; GAB | 1996 |
Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Behavior, Animal; Benzodiazepines; C | 1999 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; | 1977 |
Paradoxical effect of flurazepam.
Topics: Animals; Anticonvulsants; Cold Temperature; Electroshock; Flurazepam; Mice; Seizures; Stress, Psycho | 1992 |
Reduction of flurazepam's antiseizure efficacy persists after stress.
Topics: Animals; Anticonvulsants; Cold Temperature; Electroshock; Flurazepam; Male; Mice; Seizures; Stress, | 1992 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidi | 1991 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.
Topics: Animals; Benzodiazepines; Calcium Channels; Carbolines; Drug Tolerance; Flurazepam; Male; Mice; Nitr | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Elect | 1990 |
Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures.
Topics: Animals; Benzodiazepines; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Muscimol; Pentylenet | 1989 |
Changes in benzodiazepine/GABA receptor complex function in benzodiazepine-tolerant mice.
Topics: Animals; Anticonvulsants; Bicuculline; Body Temperature; Drug Tolerance; Flurazepam; gamma-Aminobuty | 1988 |
Benzodiazepine-receptor mediated convulsions in infant rats: effects of beta-carbolines.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Flurazepam; Pentylenetetrazole; Rats; Rats, Inbred St | 1986 |
Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142.
Topics: Animals; Benzodiazepines; Body Temperature; Carbolines; Flurazepam; Kindling, Neurologic; Mice; Pyra | 1987 |
Differential response to flurazepam in long-sleep and short-sleep mice.
Topics: 3-Mercaptopropionic Acid; Animals; Body Temperature; Dose-Response Relationship, Drug; Female; Flura | 1988 |
Relationships of brain and plasma levels of quazepam, flurazepam, and their metabolites with pharmacological activity in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Dose-Response Relationship, Drug; Electroshock | 1986 |
Reduction of flurazepam convulsive threshold by Ro 15-1788.
Topics: Animals; Benzodiazepinones; Convulsants; Electric Stimulation; Electroencephalography; Flumazenil; F | 1985 |
Anxiolytic effects of a new triazolobenzodiazepine, U-31,889.
Topics: Adult; Animals; Anxiety; Behavior, Animal; Benzodiazepinones; Blood Circulation; Central Nervous Sys | 1973 |
Quinazolines and 1,4-benzodiazepines. 69. 1-Vinyl-1,4-benzodiazepin-2-ones and 1-vinylquinazolin-2(1H)-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Chlordiazepoxide; Depression, Chemical; Diazepam | 1974 |