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flurazepam and Epilepsy

flurazepam has been researched along with Epilepsy in 4 studies

Flurazepam: A benzodiazepine derivative used mainly as a hypnotic.
flurazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"A form of endogenous (binaural) inhibition in inferior colliculus neurons, which is proposed to be GABA-mediated, was also significantly reduced in the epilepsy-prone rat as compared with the normal rat."1.27Decreased effectiveness of GABA-mediated inhibition in the inferior colliculus of the genetically epilepsy-prone rat. ( Caspary, DM; Faingold, CL; Gehlbach, G, 1986)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Deutsch, SI1
Mastropaolo, J1
Burket, JA1
Rosse, RB1
Dodson, AM1
Miller, JW1
Ferrendelli, JA1
Faingold, CL1
Gehlbach, G1
Caspary, DM1

Other Studies

4 other studies available for flurazepam and Epilepsy

ArticleYear
An epigenetic intervention interacts with genetic strain differences to modulate the stress-induced reduction of flurazepam's antiseizure efficacy in the mouse.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Butyrates; Disease Models, Animal; Dizocilpine Malea

2009
Nursing care study - drug overdose: dealing with an unknown quantity.
    Nursing mirror, 1982, Jan-27, Volume: 154, Issue:4

    Topics: Adult; Epilepsy; Female; Flurazepam; Humans; Nursing Care; Phenobarbital

1982
Characterization of GABAergic seizure regulation in the midline thalamus.
    Neuropharmacology, 1990, Volume: 29, Issue:7

    Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobut

1990
Decreased effectiveness of GABA-mediated inhibition in the inferior colliculus of the genetically epilepsy-prone rat.
    Experimental neurology, 1986, Volume: 93, Issue:1

    Topics: Animals; Bicuculline; Epilepsy; Flurazepam; GABA Antagonists; gamma-Aminobutyric Acid; Inferior Coll

1986